{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T00:50:26Z","timestamp":1789865426616,"version":"4.0.1"},"reference-count":137,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2016,7,1]],"date-time":"2016-07-01T00:00:00Z","timestamp":1467331200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2016,7,1]],"date-time":"2016-07-01T00:00:00Z","timestamp":1467331200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100006364","name":"Institut National Du Cancer","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006364","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Brain Research"],"published-print":{"date-parts":[[2016,7]]},"DOI":"10.1016\/j.brainres.2016.03.015","type":"journal-article","created":{"date-parts":[[2016,3,22]],"date-time":"2016-03-22T23:47:48Z","timestamp":1458690468000},"page":"59-69","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":19,"special_numbering":"C","title":["Signaling the Unfolded Protein Response in primary brain cancers"],"prefix":"10.1016","volume":"1642","author":[{"given":"Pierre-Jean","family":"Le Reste","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tony","family":"Avril","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V\u00e9ronique","family":"Quillien","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xavier","family":"Morandi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric","family":"Chevet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.brainres.2016.03.015_bib1","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.molcel.2007.06.011","article-title":"XBP1 controls diverse cell type- and condition-specific transcriptional regulatory networks","volume":"27","author":"Acosta-Alvear","year":"2007","journal-title":"Mol. Cell"},{"key":"10.1016\/j.brainres.2016.03.015_bib2","doi-asserted-by":"crossref","first-page":"726","DOI":"10.1111\/nan.12098","article-title":"Loss of endoplasmic reticulum calcium pump expression in choroid plexus tumours","volume":"40","author":"Ait-Ghezali","year":"2014","journal-title":"Neuropathol. Appl. Neurobiol."},{"key":"10.1016\/j.brainres.2016.03.015_bib3","doi-asserted-by":"crossref","first-page":"1099","DOI":"10.1097\/MEG.0b013e3283378405","article-title":"Unfolded protein response activation contributes to chemoresistance in hepatocellular carcinoma","volume":"22","author":"Al-Rawashdeh","year":"2010","journal-title":"Eur. J. Gastroenterol. Hepatol."},{"key":"10.1016\/j.brainres.2016.03.015_bib4","doi-asserted-by":"crossref","first-page":"3760","DOI":"10.1038\/onc.2014.292","article-title":"Anticipatory estrogen activation of the unfolded protein response is linked to cell proliferation and poor survival in estrogen receptor alpha-positive breast cancer","volume":"34","author":"Andruska","year":"2015","journal-title":"Oncogene"},{"key":"10.1016\/j.brainres.2016.03.015_bib5","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1111\/j.1365-2559.1983.tb02308.x","article-title":"The fine structure of choroid plexus carcinoma","volume":"7","author":"Anguilar","year":"1983","journal-title":"Histopathology"},{"key":"10.1016\/j.brainres.2016.03.015_bib6","doi-asserted-by":"crossref","first-page":"15553","DOI":"10.1073\/pnas.0914072107","article-title":"Inositol-requiring enzyme 1alpha is a key regulator of angiogenesis and invasion in malignant glioma","volume":"107","author":"Auf","year":"2010","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.brainres.2016.03.015_bib7","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1186\/1471-2407-13-597","article-title":"High epiregulin expression in human U87 glioma cells relies on IRE1\u03b1 and promotes autocrine growth through EGF receptor","volume":"13","author":"Auf","year":"2013","journal-title":"BMC Cancer"},{"key":"10.1016\/j.brainres.2016.03.015_bib8","doi-asserted-by":"crossref","first-page":"916","DOI":"10.1126\/science.1141448","article-title":"Adapting proteostasis for disease intervention","volume":"319","author":"Balch","year":"2008","journal-title":"Science"},{"key":"10.1016\/j.brainres.2016.03.015_bib9","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1038\/35014014","article-title":"Dynamic interaction of BiP and ER stress transducers in the unfolded-protein response","volume":"2","author":"Bertolotti","year":"2000","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.brainres.2016.03.015_bib10","doi-asserted-by":"crossref","first-page":"3470","DOI":"10.1038\/sj.emboj.7600777","article-title":"ER stress-regulated translation increases tolerance to extreme hypoxia and promotes tumor growth","volume":"24","author":"Bi","year":"2005","journal-title":"EMBO J."},{"key":"10.1016\/j.brainres.2016.03.015_bib11","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1038\/nm.2328","article-title":"Why don't we get more cancer? A proposed role of the microenvironment in restraining cancer progression","volume":"17","author":"Bissell","year":"2011","journal-title":"Nat. Med."},{"key":"10.1016\/j.brainres.2016.03.015_bib12","doi-asserted-by":"crossref","first-page":"7469","DOI":"10.1128\/MCB.24.17.7469-7482.2004","article-title":"Activating transcription factor 4 is translationally regulated by hypoxic stress","volume":"24","author":"Blais","year":"2004","journal-title":"Mol. Cell Biol."},{"key":"10.1016\/j.brainres.2016.03.015_bib13","doi-asserted-by":"crossref","first-page":"9517","DOI":"10.1128\/MCB.01145-06","article-title":"Perk-dependent translational regulation promotes tumor cell adaptation and angiogenesis in response to hypoxic stress","volume":"26","author":"Blais","year":"2006","journal-title":"Mol. Cell Biol."},{"key":"10.1016\/j.brainres.2016.03.015_bib14","doi-asserted-by":"crossref","first-page":"3115","DOI":"10.1096\/fj.11-182931","article-title":"Peptides derived from the bifunctional kinase\/RNase enzyme IRE1alpha modulate IRE1alpha activity and protect cells from endoplasmic reticulum stress","volume":"25","author":"Bouchecareilh","year":"2011","journal-title":"FASEB J."},{"key":"10.1016\/j.brainres.2016.03.015_bib15","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1038\/415092a","article-title":"IRE1 couples endoplasmic reticulum load to secretory capacity by processing the XBP-1 mRNA","volume":"415","author":"Calfon","year":"2002","journal-title":"Nature"},{"key":"10.1016\/j.brainres.2016.03.015_bib16","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1038\/nature13119","article-title":"XBP1 promotes triple-negative breast cancer by controlling the HIF1alpha pathway","volume":"508","author":"Chen","year":"2014","journal-title":"Nature"},{"key":"10.1016\/j.brainres.2016.03.015_bib17","doi-asserted-by":"crossref","first-page":"586","DOI":"10.1158\/2159-8290.CD-14-1490","article-title":"Endoplasmic reticulum stress-activated cell reprogramming in oncogenesis","volume":"5","author":"Chevet","year":"2015","journal-title":"Cancer Discov."},{"key":"10.1016\/j.brainres.2016.03.015_bib18","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1158\/0008-5472.CAN-13-0771","article-title":"Cyclophilin B supports Myc and mutant p53-dependent survival of glioblastoma multiforme cells","volume":"74","author":"Choi","year":"2014","journal-title":"Cancer Res."},{"key":"10.1016\/j.brainres.2016.03.015_bib19","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1016\/j.yexmp.2015.08.007","article-title":"Malignant progression to anaplastic meningioma: neuropathology, molecular pathology, and experimental models","volume":"99","author":"Cimino","year":"2015","journal-title":"Exp. Mol. Pathol."},{"key":"10.1016\/j.brainres.2016.03.015_bib20","doi-asserted-by":"crossref","first-page":"267831","DOI":"10.1155\/2015\/267831","article-title":"The role of mifepristone in meningiomas management: a systematic review of the literature","volume":"2015","author":"Cossu","year":"2015","journal-title":"BioMed Res. Int."},{"key":"10.1016\/j.brainres.2016.03.015_bib21","doi-asserted-by":"crossref","first-page":"899","DOI":"10.1097\/00000478-200007000-00001","article-title":"Chordoid meningioma: a clinicopathologic study of 42 cases","volume":"24","author":"Couce","year":"2000","journal-title":"Am. J. Surg. Pathol."},{"key":"10.1016\/j.brainres.2016.03.015_bib22","article-title":"The ATF6 pathway of the ER stress response contributes to enhanced viability in glioblastoma","author":"Dadey","year":"2015","journal-title":"Oncotarget"},{"key":"10.1016\/j.brainres.2016.03.015_bib23","doi-asserted-by":"crossref","first-page":"882","DOI":"10.1016\/j.neurol.2008.01.008","article-title":"Pathology of tumors of the pineal region","volume":"164","author":"De Girolami","year":"2008","journal-title":"Rev. Neurol."},{"key":"10.1016\/j.brainres.2016.03.015_bib24","first-page":"4278","article-title":"Autocrine control of glioma cells adhesion and migration through IRE1alpha-mediated cleavage of SPARC mRNA","volume":"125","author":"Dejeans","year":"2012","journal-title":"J. Cell Sci."},{"key":"10.1016\/j.brainres.2016.03.015_bib25","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1016\/j.molmed.2013.12.003","article-title":"Addicted to secrete - novel concepts and targets in cancer therapy","volume":"20","author":"Dejeans","year":"2014","journal-title":"Trends Mol. Med."},{"key":"10.1016\/j.brainres.2016.03.015_bib26","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.semcancer.2015.04.007","article-title":"Novel roles of the unfolded protein response in the control of tumor development and aggressiveness","volume":"33","author":"Dejeans","year":"2015","journal-title":"Semin. Cancer Biol."},{"key":"10.1016\/j.brainres.2016.03.015_bib27","doi-asserted-by":"crossref","first-page":"e1001945","DOI":"10.1371\/journal.pbio.1001945","article-title":"De-differentiation confers multidrug resistance via noncanonical PERK-Nrf2 signaling","volume":"12","author":"Del Vecchio","year":"2014","journal-title":"PLoS Biol."},{"key":"10.1016\/j.brainres.2016.03.015_bib28","doi-asserted-by":"crossref","first-page":"1167","DOI":"10.1016\/j.cell.2014.01.061","article-title":"Hexosamine pathway metabolites enhance protein quality control and prolong life","volume":"156","author":"Denzel","year":"2014","journal-title":"Cell"},{"key":"10.1016\/j.brainres.2016.03.015_bib29","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1007\/s12020-010-9362-0","article-title":"Atypical induction of the unfolded protein response by mifepristone","volume":"38","author":"Dioufa","year":"2010","journal-title":"Endocrine"},{"key":"10.1016\/j.brainres.2016.03.015_bib30","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1080\/03009740802213310","article-title":"Upregulation of 78-kDa glucose-regulated protein in macrophages in peripheral joints of active ankylosing spondylitis","volume":"37","author":"Dong","year":"2008","journal-title":"Scand. J. Rheumatol."},{"key":"10.1016\/j.brainres.2016.03.015_bib31","doi-asserted-by":"crossref","first-page":"6700","DOI":"10.1158\/0008-5472.CAN-06-3235","article-title":"IRE1 signaling is essential for ischemia-induced vascular endothelial growth factor-A expression and contributes to angiogenesis and tumor growth in vivo","volume":"67","author":"Drogat","year":"2007","journal-title":"Cancer Res."},{"key":"10.1016\/j.brainres.2016.03.015_bib32","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1093\/jnen\/59.4.333","article-title":"Nuclear localization and mutation of beta-catenin in medulloblastomas","volume":"59","author":"Eberhart","year":"2000","journal-title":"J. Neuropathol. Exp. Neurol."},{"key":"10.1016\/j.brainres.2016.03.015_bib33","doi-asserted-by":"crossref","first-page":"e73267","DOI":"10.1371\/journal.pone.0073267","article-title":"Induction of the unfolded protein response drives enhanced metabolism and chemoresistance in glioma cells","volume":"8","author":"Epple","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.brainres.2016.03.015_bib34","doi-asserted-by":"crossref","first-page":"723","DOI":"10.4161\/cbt.5.7.2967","article-title":"The PERK\/eIF2alpha\/ATF4 module of the UPR in hypoxia resistance and tumor growth","volume":"5","author":"Fels","year":"2006","journal-title":"Cancer Biol. Ther."},{"key":"10.1016\/j.brainres.2016.03.015_bib35","doi-asserted-by":"crossref","first-page":"702","DOI":"10.1158\/2159-8290.CD-13-0945","article-title":"Epithelial-to-mesenchymal transition activates PERK-eIF2alpha and sensitizes cells to endoplasmic reticulum stress","volume":"4","author":"Feng","year":"2014","journal-title":"Cancer Discov."},{"key":"10.1016\/j.brainres.2016.03.015_bib36","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1111\/jpi.12264","article-title":"Melatonin and endoplasmic reticulum stress: relation to autophagy and apoptosis","volume":"59","author":"Fern\u00e1ndez","year":"2015","journal-title":"J. Pineal Res."},{"key":"10.1016\/j.brainres.2016.03.015_bib37","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1023\/A:1006332011207","article-title":"Overexpression of the glucose-regulated stress gene GRP78 in malignant but not benign human breast lesions","volume":"59","author":"Fernandez","year":"2000","journal-title":"Breast Cancer Res. Treat."},{"key":"10.1016\/j.brainres.2016.03.015_bib38","doi-asserted-by":"crossref","first-page":"820","DOI":"10.1016\/j.molcel.2014.04.026","article-title":"O-GlcNAcylation regulates cancer metabolism and survival stress signaling via regulation of the HIF-1 pathway","volume":"54","author":"Ferrer","year":"2014","journal-title":"Mol. Cell"},{"key":"10.1016\/j.brainres.2016.03.015_bib39","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1111\/j.1365-2990.2007.00891.x","article-title":"Histological features and expression of enzymes implicated in melatonin synthesis in pineal parenchymal tumours and in cultured tumoural pineal cells","volume":"34","author":"Fevre-Montange","year":"2008","journal-title":"Neuropathol. Appl. Neurobiol."},{"key":"10.1016\/j.brainres.2016.03.015_bib40","doi-asserted-by":"crossref","first-page":"e741","DOI":"10.1038\/cddis.2013.265","article-title":"GRP78-targeting subtilase cytotoxin sensitizes cancer cells to photodynamic therapy","volume":"4","author":"Firczuk","year":"2013","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.brainres.2016.03.015_bib41","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1016\/j.urology.2009.05.007","article-title":"Upregulation of GRP78 in renal cell carcinoma and its significance","volume":"75","author":"Fu","year":"2010","journal-title":"Urology"},{"key":"10.1016\/j.brainres.2016.03.015_bib42","first-page":"127","article-title":"Overexpression of human X-box binding protein 1 (XBP-1) in colorectal adenomas and adenocarcinomas","volume":"27","author":"Fujimoto","year":"2007","journal-title":"Anticancer Res."},{"key":"10.1016\/j.brainres.2016.03.015_bib43","doi-asserted-by":"crossref","first-page":"534","DOI":"10.1016\/j.cell.2014.07.002","article-title":"Allosteric inhibition of the IRE1alpha RNase preserves cell viability and function during endoplasmic reticulum stress","volume":"158","author":"Ghosh","year":"2014","journal-title":"Cell"},{"key":"10.1016\/j.brainres.2016.03.015_bib44","doi-asserted-by":"crossref","first-page":"526","DOI":"10.4161\/cbt.9.7.11116","article-title":"OSU-03012 enhances Ad.7-induced GBM cell killing via ER stress and autophagy and by decreasing expression of mitochondrial protective proteins","volume":"9","author":"Hamed","year":"2010","journal-title":"Cancer Biol. Ther."},{"key":"10.1016\/j.brainres.2016.03.015_bib45","doi-asserted-by":"crossref","first-page":"562","DOI":"10.1016\/j.cell.2009.07.017","article-title":"IRE1alpha kinase activation modes control alternate endoribonuclease outputs to determine divergent cell fates","volume":"138","author":"Han","year":"2009","journal-title":"Cell"},{"key":"10.1016\/j.brainres.2016.03.015_bib46","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1038\/ncb2738","article-title":"ER-stress-induced transcriptional regulation increases protein synthesis leading to cell death","volume":"15","author":"Han","year":"2013","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.brainres.2016.03.015_bib47","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1016\/j.cell.2011.02.013","article-title":"Hallmarks of cancer: the next generation","volume":"144","author":"Hanahan","year":"2011","journal-title":"Cell"},{"key":"10.1016\/j.brainres.2016.03.015_bib48","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1038\/16729","article-title":"Protein translation and folding are coupled by an endoplasmic-reticulum-resident kinase","volume":"397","author":"Harding","year":"1999","journal-title":"Nature"},{"key":"10.1016\/j.brainres.2016.03.015_bib49","doi-asserted-by":"crossref","first-page":"4621","DOI":"10.1172\/JCI62973","article-title":"ER stress-mediated autophagy promotes Myc-dependent transformation and tumor growth","volume":"122","author":"Hart","year":"2013","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.brainres.2016.03.015_bib50","doi-asserted-by":"crossref","first-page":"3146","DOI":"10.4049\/jimmunol.1303098","article-title":"Secretion and immunogenicity of the meningioma-associated antigen TXNDC16","volume":"193","author":"Harz","year":"2014","journal-title":"J. Immunol."},{"key":"10.1016\/j.brainres.2016.03.015_bib51","doi-asserted-by":"crossref","first-page":"808","DOI":"10.1016\/j.wneu.2014.12.037","article-title":"The role of adjuvant radiotherapy after gross total resection of atypical meningiomas","volume":"83","author":"Hasan","year":"2015","journal-title":"World Neurosurg."},{"key":"10.1016\/j.brainres.2016.03.015_bib52","doi-asserted-by":"crossref","first-page":"3787","DOI":"10.1091\/mbc.10.11.3787","article-title":"Mammalian transcription factor ATF6 is synthesized as a transmembrane protein and activated by proteolysis in response to endoplasmic reticulum stress","volume":"10","author":"Haze","year":"1999","journal-title":"Mol. Biol. Cell"},{"key":"10.1016\/j.brainres.2016.03.015_bib53","doi-asserted-by":"crossref","first-page":"1128","DOI":"10.1016\/j.celrep.2013.02.031","article-title":"ER stress causes rapid loss of intestinal epithelial stemness through activation of the unfolded protein response","volume":"3","author":"Heijmans","year":"2013","journal-title":"Cell Rep."},{"key":"10.1016\/j.brainres.2016.03.015_bib54","doi-asserted-by":"crossref","first-page":"2294","DOI":"10.1101\/gad.1830709","article-title":"XBP-1 deficiency in the nervous system protects against amyotrophic lateral sclerosis by increasing autophagy","volume":"23","author":"Hetz","year":"2009","journal-title":"Genes Dev."},{"key":"10.1016\/j.brainres.2016.03.015_bib55","doi-asserted-by":"crossref","first-page":"1219","DOI":"10.1152\/physrev.00001.2011","article-title":"The unfolded protein response: integrating stress signals through the stress sensor IRE1alpha","volume":"91","author":"Hetz","year":"2011","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.brainres.2016.03.015_bib56","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1038\/nrd3976","article-title":"Targeting the unfolded protein response in disease","volume":"12","author":"Hetz","year":"2013","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.brainres.2016.03.015_bib57","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1038\/ncb3184","article-title":"Proteostasis control by the unfolded protein response","volume":"17","author":"Hetz","year":"2015","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.brainres.2016.03.015_bib58","doi-asserted-by":"crossref","first-page":"1839","DOI":"10.1128\/MCB.01484-13","article-title":"Endoplasmic reticulum stress-activated transcription factor ATF6alpha requires the disulfide isomerase PDIA5 to modulate chemoresistance","volume":"34","author":"Higa","year":"2014","journal-title":"Mol. Cell Biol."},{"key":"10.1016\/j.brainres.2016.03.015_bib59","doi-asserted-by":"crossref","first-page":"907","DOI":"10.1517\/17460440903055032","article-title":"Implications of endoplasmic reticulum stress, the unfolded protein response and apoptosis for molecular cancer therapy. Part II: targeting cell cycle events, caspases, NF-kappaB and the proteasome","volume":"4","author":"Hiss","year":"2009","journal-title":"Expert Opin. Drug Discov."},{"key":"10.1016\/j.brainres.2016.03.015_bib60","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1007\/BF00687211","article-title":"Ultrastructure of cerebellar capillary hemangioblastoma. VI. Concentric lamellar bodies of endoplasmic reticulum in stromal cells","volume":"74","author":"Ho","year":"1987","journal-title":"Acta Neuropathologica."},{"key":"10.1016\/j.brainres.2016.03.015_bib61","first-page":"956","article-title":"Microtubular aggregates within rough endoplasmic reticulum in myxopapillary ependymoma of the filum terminale","volume":"114","author":"Ho","year":"1990","journal-title":"Arch.\u00a0Pathol. Lab. Med."},{"key":"10.1016\/j.brainres.2016.03.015_bib62","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1186\/1471-2091-2-4","article-title":"Upregulation of the SERCA-type Ca2+pump activity in response to endoplasmic reticulum stress in PC12 cells","volume":"2","author":"H\u00f8jmann Larsen","year":"2001","journal-title":"BMC Biochem."},{"key":"10.1016\/j.brainres.2016.03.015_bib63","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1126\/science.1129631","article-title":"Decay of endoplasmic reticulum-localized mRNAs during the unfolded protein response","volume":"313","author":"Hollien","year":"2006","journal-title":"Science"},{"key":"10.1016\/j.brainres.2016.03.015_bib64","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1083\/jcb.200903014","article-title":"Regulated Ire1-dependent decay of messenger RNAs in mammalian cells","volume":"186","author":"Hollien","year":"2009","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.brainres.2016.03.015_bib65","doi-asserted-by":"crossref","first-page":"9065","DOI":"10.1038\/srep09065","article-title":"PERK silence inhibits glioma cell growth under low glucose stress by blockage of p-AKT and subsequent HK2\u2019s mitochondria translocation","volume":"5","author":"Hou","year":"2015","journal-title":"Sci. Rep."},{"key":"10.1016\/j.brainres.2016.03.015_bib66","first-page":"147","article-title":"An integrative analysis of meningioma tumors reveals the determinant genes and pathways of malignant transformation","volume":"4","author":"Iglesias G\u00f3mez","year":"2014","journal-title":"Front. Oncol."},{"key":"10.1016\/j.brainres.2016.03.015_bib67","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1038\/35055065","article-title":"Translational control by the ER transmembrane kinase\/ribonuclease IRE1 under ER stress","volume":"3","author":"Iwawaki","year":"2001","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.brainres.2016.03.015_bib68","doi-asserted-by":"crossref","first-page":"24922","DOI":"10.18632\/oncotarget.4679","article-title":"Glioblastoma invasion and cooption depend on IRE1\u03b1 endoribonuclease activity","volume":"6","author":"Jabouille","year":"2015","journal-title":"Oncotarget"},{"key":"10.1016\/j.brainres.2016.03.015_bib69","doi-asserted-by":"crossref","first-page":"e0120252","DOI":"10.1371\/journal.pone.0120252","article-title":"Pancreatic endoplasmic reticulum kinase activation promotes medulloblastoma cell migration and invasion through induction of vascular endothelial growth factor A","volume":"10","author":"Jamison","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.brainres.2016.03.015_bib70","doi-asserted-by":"crossref","first-page":"4093","DOI":"10.1200\/JCO.2015.61.6490","article-title":"Double-blind phase III randomized trial of the antiprogestin agent mifepristone in the treatment of unresectable meningioma: SWOG S9005","volume":"33","author":"Ji","year":"2015","journal-title":"J. Clin. Oncol."},{"key":"10.1016\/j.brainres.2016.03.015_bib71","doi-asserted-by":"crossref","first-page":"1086","DOI":"10.1093\/neuonc\/nou012","article-title":"The deadly connection between endoplasmic reticulum, Ca2+, protein synthesis, and the endoplasmic reticulum stress response in malignant glioma cells","volume":"16","author":"Johnson","year":"2014","journal-title":"Neuro Oncol."},{"key":"10.1016\/j.brainres.2016.03.015_bib72","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1097\/00000478-200304000-00011","article-title":"Papillary tumor of the pineal region","volume":"27","author":"Jouvet","year":"2003","journal-title":"Am. J. Surg. Pathol."},{"key":"10.1016\/j.brainres.2016.03.015_bib73","doi-asserted-by":"crossref","DOI":"10.15252\/embj.201490332","article-title":"The mammalian tRNA ligase complex mediates splicing of XBP1 mRNA and controls antibody secretion in plasma cells","author":"Jurkin","year":"2014","journal-title":"EMBO J."},{"key":"10.1016\/j.brainres.2016.03.015_bib74","doi-asserted-by":"crossref","first-page":"1692","DOI":"10.1002\/1097-0142(197911)44:5<1692::AID-CNCR2820440524>3.0.CO;2-K","article-title":"Pineoblastoma: an electron microscopic study","volume":"44","author":"Kline","year":"1979","journal-title":"Cancer"},{"key":"10.1016\/j.brainres.2016.03.015_bib75","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1016\/j.taap.2008.01.009","article-title":"Evidence of galectin-1 involvement in glioma chemoresistance","volume":"229","author":"Le Mercier","year":"2008","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.brainres.2016.03.015_bib76","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1097\/NEN.0b013e318170f892","article-title":"Knocking down galectin 1 in human hs683 glioblastoma cells impairs both angiogenesis and endoplasmic reticulum stress responses","volume":"67","author":"Le Mercier","year":"2008","journal-title":"J. Neuropathol. Exp. Neurol."},{"key":"10.1016\/j.brainres.2016.03.015_bib77","doi-asserted-by":"crossref","first-page":"7849","DOI":"10.1158\/0008-5472.CAN-06-1660","article-title":"GRP78 as a novel predictor of responsiveness to chemotherapy in breast cancer","volume":"66","author":"Lee","year":"2006","journal-title":"Cancer Res."},{"key":"10.1016\/j.brainres.2016.03.015_bib78","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1215\/15228517-2008-006","article-title":"GRP78 is overexpressed in glioblastomas and regulates glioma cell growth and apoptosis","volume":"10","author":"Lee","year":"2008","journal-title":"Neuro Oncol."},{"key":"10.1016\/j.brainres.2016.03.015_bib79","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1101\/gad.964702","article-title":"IRE1-mediated unconventional mRNA splicing and S2P-mediated ATF6 cleavage merge to regulate XBP1 in signaling the unfolded protein response","volume":"16","author":"Lee","year":"2002","journal-title":"Genes Dev."},{"key":"10.1016\/j.brainres.2016.03.015_bib80","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1016\/j.cmet.2012.07.007","article-title":"IRE1alpha induces thioredoxin-interacting protein to activate the NLRP3 inflammasome and promote programmed cell death under irremediable ER stress","volume":"16","author":"Lerner","year":"2012","journal-title":"Cell Metab."},{"key":"10.1016\/j.brainres.2016.03.015_bib81","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1038\/nature10826","article-title":"Outgrowth of single oncogene-expressing cells from suppressive epithelial environments","volume":"482","author":"Leung","year":"2012","journal-title":"Nature"},{"key":"10.1016\/j.brainres.2016.03.015_bib82","first-page":"206","article-title":"The ultrastructure of oligodendroglioma: personal experience and the review of the literature","volume":"34","author":"Liberski","year":"1996","journal-title":"Folia Neuropathol."},{"key":"10.1016\/j.brainres.2016.03.015_bib83","first-page":"161","article-title":"The ultrastructure of glial tumors of astrocytic lineage: a review","volume":"36","author":"Liberski","year":"1998","journal-title":"Folia Neuropathol."},{"key":"10.1016\/j.brainres.2016.03.015_bib84","doi-asserted-by":"crossref","first-page":"1586","DOI":"10.1002\/jnr.22693","article-title":"A deregulated integrated stress response promotes interferon-\u03b3-induced medulloblastoma","volume":"89","author":"Lin","year":"2011","journal-title":"J. Neurosci. Res."},{"key":"10.1016\/j.brainres.2016.03.015_bib85","doi-asserted-by":"crossref","first-page":"966","DOI":"10.1038\/nrc1505","article-title":"The role of the unfolded protein response in tumour development: friend or foe?","volume":"4","author":"Ma","year":"2004","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.brainres.2016.03.015_bib86","doi-asserted-by":"crossref","first-page":"1841","DOI":"10.4161\/cc.20242","article-title":"Integrating role of T antigen, Rb2\/p130, CTCF and BORIS in mediating non-canonical endoplasmic reticulum-dependent death pathways triggered by chronic ER stress in mouse medulloblastoma","volume":"11","author":"Macaluso","year":"2012","journal-title":"Cell Cycle"},{"key":"10.1016\/j.brainres.2016.03.015_bib87","doi-asserted-by":"crossref","first-page":"C901","DOI":"10.1152\/ajpcell.00292.2014","article-title":"Cellular mechanisms of endoplasmic reticulum stress signaling in health and disease. 3. Orchestrating the unfolded protein response in oncogenesis: an update","volume":"307","author":"Manie","year":"2014","journal-title":"Am. J. Physiol. Cell Physiol."},{"key":"10.1016\/j.brainres.2016.03.015_bib88","doi-asserted-by":"crossref","first-page":"736","DOI":"10.4161\/cbt.5.7.2969","article-title":"UPR activation alters chemosensitivity of tumor cells","volume":"5","author":"Mann","year":"2006","journal-title":"Cancer Biol. Ther."},{"key":"10.1016\/j.brainres.2016.03.015_bib89","doi-asserted-by":"crossref","first-page":"2375","DOI":"10.1128\/MCB.01445-12","article-title":"The unfolded protein response selectively targets active smoothened mutants","volume":"33","author":"Marada","year":"2013","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.brainres.2016.03.015_bib90","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1007\/s11864-014-0306-4","article-title":"Management of pediatric and adult patients with medulloblastoma","volume":"15","author":"Martin","year":"2014","journal-title":"Curr. Treat. Options Oncol."},{"key":"10.1016\/j.brainres.2016.03.015_bib91","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/j.tibs.2014.02.008","article-title":"Getting RIDD of RNA: IRE1 in cell fate regulation","volume":"39","author":"Maurel","year":"2014","journal-title":"Trends Biochem. Sci."},{"key":"10.1016\/j.brainres.2016.03.015_bib92","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1002\/1097-0142(19830201)51:3<470::AID-CNCR2820510319>3.0.CO;2-K","article-title":"Choroid plexus carcinoma. Report of a case with immunohistochemical and ultrastructural observations","volume":"51","author":"McComb","year":"1983","journal-title":"Cancer"},{"key":"10.1016\/j.brainres.2016.03.015_bib93","doi-asserted-by":"crossref","first-page":"197","DOI":"10.3233\/CBM-140454","article-title":"Expression of glucose regulated protein 78 (GRP78) determines colorectal cancer response to chemotherapy","volume":"15","author":"Mhaidat","year":"2015","journal-title":"Cancer Biomark."},{"key":"10.1016\/j.brainres.2016.03.015_bib94","doi-asserted-by":"crossref","first-page":"E18","DOI":"10.3171\/2013.10.FOCUS13341","article-title":"Recent developments in chemotherapy for meningiomas: a review","volume":"35","author":"Moazzam","year":"2013","journal-title":"Neurosurg. Focus"},{"key":"10.1016\/j.brainres.2016.03.015_bib95","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1111\/j.1365-2990.2006.00711.x","article-title":"Rarity of JC virus DNA sequences and early proteins in human gliomas and medulloblastomas: the controversial role of JC virus in human neurooncogenesis","volume":"32","author":"Mu\u00f1oz-M\u00e1rmol","year":"2006","journal-title":"Neuropathol. Appl. Neurobiol."},{"key":"10.1016\/j.brainres.2016.03.015_bib96","doi-asserted-by":"crossref","DOI":"10.1093\/neuonc\/nou240.23","article-title":"BM-23Twist1 expression confirms the role of an EMT-like process in medulloblastoma metastasis","volume":"16","author":"Nasir","year":"2014","journal-title":"Neuro Oncol."},{"key":"10.1016\/j.brainres.2016.03.015_bib97","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1083\/jcb.201504109","article-title":"Forcible destruction of severely misfolded mammalian glycoproteins by the non-glycoprotein ERAD pathway","volume":"211","author":"Ninagawa","year":"2015","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.brainres.2016.03.015_bib98","doi-asserted-by":"crossref","first-page":"16067","DOI":"10.1038\/srep16067","article-title":"Elevated GRP78 expression is associated with poor prognosis in patients with pancreatic cancer","volume":"5","author":"Niu","year":"2015","journal-title":"Sci. Rep."},{"key":"10.1016\/j.brainres.2016.03.015_bib99","doi-asserted-by":"crossref","first-page":"1408","DOI":"10.1200\/JCO.2009.27.4324","article-title":"Medulloblastoma comprises four distinct molecular variants","volume":"29","author":"Northcott","year":"2011","journal-title":"J. Clin. Oncol."},{"key":"10.1016\/j.brainres.2016.03.015_bib100","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1038\/nrneurol.2012.78","article-title":"The clinical implications of medulloblastoma subgroups","volume":"8","author":"Northcott","year":"2012","journal-title":"Nat. Rev. Neurol."},{"key":"10.1016\/j.brainres.2016.03.015_bib101","doi-asserted-by":"crossref","first-page":"1011","DOI":"10.1083\/jcb.153.5.1011","article-title":"Feedback inhibition of the unfolded protein response by GADD34-mediated dephosphorylation of eIF2alpha","volume":"153","author":"Novoa","year":"2001","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.brainres.2016.03.015_bib102","doi-asserted-by":"crossref","first-page":"9220","DOI":"10.1128\/MCB.01453-06","article-title":"Autophagy is activated for cell survival after endoplasmic reticulum stress","volume":"26","author":"Ogata","year":"2006","journal-title":"Mol. Cell Biol."},{"key":"10.1016\/j.brainres.2016.03.015_bib103","first-page":"4206","article-title":"Regulation of tumor angiogenesis by oxygen-regulated protein 150, an inducible endoplasmic reticulum chaperone","volume":"61","author":"Ozawa","year":"2001","journal-title":"Cancer Res."},{"key":"10.1016\/j.brainres.2016.03.015_bib104","doi-asserted-by":"crossref","first-page":"1609","DOI":"10.1093\/neuonc\/nov126","article-title":"Long-term results of carmustine wafer implantation for newly diagnosed glioblastomas: a controlled propensity-matched analysis of a French multicenter cohort","volume":"17","author":"Pallud","year":"2015","journal-title":"Neuro Oncol."},{"key":"10.1016\/j.brainres.2016.03.015_bib105","doi-asserted-by":"crossref","first-page":"4732","DOI":"10.1158\/0008-5472.CAN-12-3989","article-title":"Posttranscriptional regulation of PER1 underlies the oncogenic function of IREalpha","volume":"73","author":"Pluquet","year":"2013","journal-title":"Cancer Res."},{"key":"10.1016\/j.brainres.2016.03.015_bib106","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1007\/s11060-010-0468-2","article-title":"A role for MT1-MMP as a cell death sensor\/effector through the regulation of endoplasmic reticulum stress in U87 glioblastoma cells","volume":"104","author":"Proulx-Bonneau","year":"2011","journal-title":"J. Neurooncol."},{"key":"10.1016\/j.brainres.2016.03.015_bib107","doi-asserted-by":"crossref","first-page":"9809","DOI":"10.1158\/0008-5472.CAN-07-0625","article-title":"The unfolded protein response regulator GRP78\/BiP as a novel target for increasing chemosensitivity in malignant gliomas","volume":"67","author":"Pyrko","year":"2007","journal-title":"Cancer Res."},{"key":"10.1016\/j.brainres.2016.03.015_bib108","doi-asserted-by":"crossref","first-page":"487","DOI":"10.3892\/etm.2011.422","article-title":"CHOP and caspase 3 induction underlie glioblastoma cell death in response to endoplasmic reticulum stress","volume":"3","author":"Quick","year":"2012","journal-title":"Exp. Ther. Med."},{"key":"10.1016\/j.brainres.2016.03.015_bib109","doi-asserted-by":"crossref","first-page":"1513","DOI":"10.1182\/blood-2008-05-157040","article-title":"Targeting PKC: a novel role for beta-catenin in ER stress and apoptotic signaling","volume":"113","author":"Raab","year":"2009","journal-title":"Blood"},{"key":"10.1016\/j.brainres.2016.03.015_bib110","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1002\/1097-0029(20010101)52:1<104::AID-JEMT12>3.0.CO;2-3","article-title":"Tumors of the choroid plexus","volume":"52","author":"Rickert","year":"2001","journal-title":"Microsc. Res. Tech."},{"key":"10.1016\/j.brainres.2016.03.015_bib111","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1172\/JCI40027","article-title":"The unfolded protein response protects human tumor cells during hypoxia through regulation of the autophagy genes MAP1LC3B and ATG5","volume":"120","author":"Rouschop","year":"2010","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.brainres.2016.03.015_bib112","doi-asserted-by":"crossref","first-page":"1165","DOI":"10.1016\/S1097-2765(01)00265-9","article-title":"Translational control is required for the unfolded protein response and in vivo glucose homeostasis","volume":"7","author":"Scheuner","year":"2001","journal-title":"Mol. Cell"},{"key":"10.1016\/j.brainres.2016.03.015_bib113","doi-asserted-by":"crossref","first-page":"10519","DOI":"10.1073\/pnas.0800939105","article-title":"ATF6alpha-Rheb-mTOR signaling promotes survival of dormant tumor cells in vivo","volume":"105","author":"Schewe","year":"2008","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.brainres.2016.03.015_bib114","doi-asserted-by":"crossref","first-page":"770","DOI":"10.1038\/35008096","article-title":"Rapid degradation of a large fraction of newly synthesized proteins by proteasomes","volume":"404","author":"Schubert","year":"2000","journal-title":"Nature"},{"key":"10.1016\/j.brainres.2016.03.015_bib115","doi-asserted-by":"crossref","first-page":"1692","DOI":"10.1038\/sj.bjc.6605365","article-title":"Activation and clinical significance of the unfolded protein response in breast cancer","volume":"101","author":"Scriven","year":"2009","journal-title":"Br. J. Cancer"},{"key":"10.1016\/j.brainres.2016.03.015_bib116","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/S1534-5807(02)00203-4","article-title":"ER stress regulation of ATF6 localization by dissociation of BiP\/GRP78 binding and unmasking of Golgi localization signals","volume":"3","author":"Shen","year":"2002","journal-title":"Dev. Cell"},{"key":"10.1016\/j.brainres.2016.03.015_bib117","doi-asserted-by":"crossref","first-page":"788","DOI":"10.15252\/emmm.201404509","article-title":"Divergent androgen regulation of unfolded protein response pathways drives prostate cancer","volume":"7","author":"Sheng","year":"2015","journal-title":"EMBO Mol. Med."},{"key":"10.1016\/j.brainres.2016.03.015_bib118","doi-asserted-by":"crossref","first-page":"6318","DOI":"10.1158\/0008-5472.CAN-14-0798","article-title":"SCCA1\/SERPINB3 promotes oncogenesis and epithelial-mesenchymal transition via the unfolded protein response and IL6 signaling","volume":"74","author":"Sheshadri","year":"2014","journal-title":"Cancer Res."},{"key":"10.1016\/j.brainres.2016.03.015_bib119","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1016\/S0168-8278(03)00029-1","article-title":"Activation of the ATF6, XBP1 and grp78 genes in human hepatocellular carcinoma: a possible involvement of the ER stress pathway in hepatocarcinogenesis","volume":"38","author":"Shuda","year":"2003","journal-title":"J. Hepatol."},{"key":"10.1016\/j.brainres.2016.03.015_bib120","doi-asserted-by":"crossref","first-page":"987","DOI":"10.1056\/NEJMoa043330","article-title":"Radiotherapy plus concomitant and adjuvant temozolomide for glioblastoma","volume":"352","author":"Stupp","year":"2005","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.brainres.2016.03.015_bib121","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1007\/s10143-013-0499-1","article-title":"Current management of choroid plexus carcinomas","volume":"37","author":"Sun","year":"2014","journal-title":"Neurosurg. Rev."},{"key":"10.1016\/j.brainres.2016.03.015_bib122","doi-asserted-by":"crossref","first-page":"562","DOI":"10.1093\/neuonc\/not005","article-title":"Inhibition of prolyl 4-hydroxylase, beta polypeptide (P4HB) attenuates temozolomide resistance in malignant glioma via the endoplasmic reticulum stress response (ERSR) pathways","volume":"15","author":"Sun","year":"2013","journal-title":"Neuro Oncol."},{"key":"10.1016\/j.brainres.2016.03.015_bib123","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1007\/BF00684834","article-title":"The ultrastructure of pinealomas","volume":"24","author":"Tabuchi","year":"1973","journal-title":"Acta Neuropathol."},{"key":"10.1016\/j.brainres.2016.03.015_bib124","doi-asserted-by":"crossref","first-page":"850","DOI":"10.1016\/j.celrep.2014.09.016","article-title":"Ire1 has distinct catalytic mechanisms for XBP1\/HAC1 splicing and RIDD","volume":"9","author":"Tam","year":"2014","journal-title":"Cell Rep."},{"key":"10.1016\/j.brainres.2016.03.015_bib125","doi-asserted-by":"crossref","first-page":"1779","DOI":"10.1038\/cdd.2012.60","article-title":"CD147 induces UPR to inhibit apoptosis and chemosensitivity by increasing the transcription of Bip in hepatocellular carcinoma","volume":"19","author":"Tang","year":"2012","journal-title":"Cell Death Differ."},{"key":"10.1016\/j.brainres.2016.03.015_bib126","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1007\/BF00687458","article-title":"Intercisternal structures of closely arranged endoplasmic reticulum in human meningioma","volume":"23","author":"Tani","year":"1973","journal-title":"Acta Neuropathol."},{"key":"10.1016\/j.brainres.2016.03.015_bib127","doi-asserted-by":"crossref","first-page":"1812","DOI":"10.1101\/gad.12.12.1812","article-title":"A stress response pathway from the endoplasmic reticulum to the nucleus requires a novel bifunctional protein kinase\/endoribonuclease (Ire1p) in mammalian cells","volume":"12","author":"Tirasophon","year":"1998","journal-title":"Genes Dev."},{"key":"10.1016\/j.brainres.2016.03.015_bib128","doi-asserted-by":"crossref","first-page":"4921","DOI":"10.1038\/onc.2012.514","article-title":"Endoplasmic reticulum ribosome-binding protein 1 (RRBP1) overexpression is frequently found in lung cancer patients and alleviates intracellular stress-induced apoptosis through the enhancement of GRP78","volume":"32","author":"Tsai","year":"2013","journal-title":"Oncogene"},{"key":"10.1016\/j.brainres.2016.03.015_bib129","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1242\/jcs.017202","article-title":"ER stress is associated with dedifferentiation and an epithelial-to-mesenchymal transition-like phenotype in PC Cl3 thyroid cells","volume":"121","author":"Ulianich","year":"2008","journal-title":"J. Cell Sci."},{"key":"10.1016\/j.brainres.2016.03.015_bib130","doi-asserted-by":"crossref","first-page":"818","DOI":"10.1126\/science.1226191","article-title":"IRE1alpha cleaves select microRNAs during ER stress to derepress translation of proapoptotic Caspase-2","volume":"338","author":"Upton","year":"2012","journal-title":"Science"},{"key":"10.1016\/j.brainres.2016.03.015_bib131","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1038\/nrc3744","article-title":"Stem cell dynamics in homeostasis and cancer of the intestine","volume":"14","author":"Vermeulen","year":"2014","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.brainres.2016.03.015_bib132","doi-asserted-by":"crossref","first-page":"1179","DOI":"10.1016\/j.cell.2014.01.014","article-title":"Spliced X-box binding protein 1 couples the unfolded protein response to hexosamine biosynthetic pathway","volume":"156","author":"Wang","year":"2014","journal-title":"Cell"},{"key":"10.1016\/j.brainres.2016.03.015_bib133","doi-asserted-by":"crossref","first-page":"15017","DOI":"10.1038\/nrdp.2015.17","article-title":"Glioma","author":"Weller","year":"2015","journal-title":"Nat. Rev. Dis. Prim."},{"key":"10.1016\/j.brainres.2016.03.015_bib134","doi-asserted-by":"crossref","first-page":"2268","DOI":"10.1002\/ijc.25102","article-title":"Ras inhibits endoplasmic reticulum stress in human cancer cells with amplified Myc","volume":"126","author":"Yaari-Stark","year":"2010","journal-title":"Int. J.\u00a0Cancer"},{"key":"10.1016\/j.brainres.2016.03.015_bib135","doi-asserted-by":"crossref","first-page":"1120","DOI":"10.1158\/0008-5472.CAN-09-4043","article-title":"PERK-dependent regulation of ceramide synthase 6 and thioredoxin play a key role in mda-7\/IL-24-induced killing of primary human glioblastoma multiforme cells","volume":"70","author":"Yacoub","year":"2010","journal-title":"Cancer Res."},{"key":"10.1016\/j.brainres.2016.03.015_bib136","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1016\/j.devcel.2007.07.018","article-title":"Transcriptional induction of mammalian ER quality control proteins is mediated by single or combined action of ATF6alpha and XBP1","volume":"13","author":"Yamamoto","year":"2007","journal-title":"Dev. Cell"},{"key":"10.1016\/j.brainres.2016.03.015_bib137","doi-asserted-by":"crossref","first-page":"411","DOI":"10.2174\/156652409788167096","article-title":"ATF4, an ER stress and hypoxia-inducible transcription factor and its potential role in hypoxia tolerance and tumorigenesis","volume":"9","author":"Ye","year":"2009","journal-title":"Curr. Mol. Med."}],"container-title":["Brain Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006899316301561?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006899316301561?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,2]],"date-time":"2025-11-02T17:01:28Z","timestamp":1762102888000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006899316301561"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,7]]},"references-count":137,"alternative-id":["S0006899316301561"],"URL":"https:\/\/doi.org\/10.1016\/j.brainres.2016.03.015","relation":{},"ISSN":["0006-8993"],"issn-type":[{"value":"0006-8993","type":"print"}],"subject":[],"published":{"date-parts":[[2016,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Signaling the Unfolded Protein Response in primary brain cancers","name":"articletitle","label":"Article Title"},{"value":"Brain Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.brainres.2016.03.015","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}