{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T00:37:40Z","timestamp":1785285460026,"version":"3.55.0"},"reference-count":58,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2016,7,1]],"date-time":"2016-07-01T00:00:00Z","timestamp":1467331200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2017,5,11]],"date-time":"2017-05-11T00:00:00Z","timestamp":1494460800000},"content-version":"vor","delay-in-days":314,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"name":"CAPES\/PROEX, FAPESP","award":["2013\/15084-5"],"award-info":[{"award-number":["2013\/15084-5"]}]}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Brain Research"],"published-print":{"date-parts":[[2016,7]]},"DOI":"10.1016\/j.brainres.2016.04.073","type":"journal-article","created":{"date-parts":[[2016,5,2]],"date-time":"2016-05-02T06:01:56Z","timestamp":1462168916000},"page":"152-158","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":22,"special_numbering":"C","title":["Distinct effect of 5-HT1A and 5-HT2A receptors in the medial nucleus of the amygdala on tonic immobility behavior"],"prefix":"10.1016","volume":"1643","author":[{"given":"Bruna Balbino","family":"de Paula","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christie Ramos Andrade","family":"Leite-Panissi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.brainres.2016.04.073_bib1","doi-asserted-by":"crossref","first-page":"994","DOI":"10.1152\/jn.00744.2003","article-title":"Median and dorsal raphe neurons are not electrophysiologically identical","volume":"91","author":"Beck","year":"2004","journal-title":"J. Neurophysiol."},{"key":"10.1016\/j.brainres.2016.04.073_bib1221","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1016\/j.brainres.2010.11.055","article-title":"Distribution of 5-HT2A receptor immunoreactivity in the rat amygdaloid complex and colocalization with \u03b3-aminobutyric acid","volume":"1370","author":"Bombardi","year":"2011","journal-title":"Brain Res."},{"key":"10.1016\/j.brainres.2016.04.073_bib2","doi-asserted-by":"crossref","first-page":"68","DOI":"10.3389\/fphar.2014.00068","article-title":"Neuronal localizations of the 5-HT2 receptor family in the amygdaloid complex","volume":"5","author":"Bombardi","year":"2014","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.brainres.2016.04.073_bib3","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1016\/S0091-3057(01)00685-2","article-title":"The medial hypothalamic defensive system: hodological organization and functional implications","volume":"71","author":"Canteras","year":"2002","journal-title":"Pharmacol. Biochem. Behav."},{"issue":"2","key":"10.1016\/j.brainres.2016.04.073_bib4","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1002\/cne.903600203","article-title":"Organization of projections from the medial nucleus of the amygdala","volume":"360","author":"Canteras","year":"1995","journal-title":"J. Comp. Neurol."},{"key":"10.1016\/j.brainres.2016.04.073_bib5","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1016\/j.neubiorev.2014.03.020","article-title":"Executive and modulatory neural circuits of defensive reactions: implications for panic disorders","volume":"46","author":"Canteras","year":"2014","journal-title":"Neurosci. Behav. Rev."},{"key":"10.1016\/j.brainres.2016.04.073_bib6","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/0166-4328(84)90202-X","article-title":"Physiological characteristics of pressure immobility. Effect of morphine, naloxone and pain","volume":"12","author":"Carli","year":"1984","journal-title":"Behav. Brain Res."},{"issue":"04","key":"10.1016\/j.brainres.2016.04.073_bib7","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1017\/S1092852912000971","article-title":"Glutamate system as target for development of novel antidepressants","volume":"18","author":"Catena-Dell\u2019Osso","year":"2013","journal-title":"CNS Spectr."},{"key":"10.1016\/j.brainres.2016.04.073_bib1331","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/0006-8993(94)01272-J","article-title":"Differential involvement of the right and left amygdalae in expression of memory for aversively motivated training","volume":"670","author":"Coleman-Mesches","year":"1995","journal-title":"Brain Res."},{"issue":"1","key":"10.1016\/j.brainres.2016.04.073_bib8","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.brainresbull.2006.12.005","article-title":"Role of opioidergic and GABAergic neurotransmission of the nucleus raphe magnus in the modulation of tonic immobility in guinea pigs","volume":"72","author":"Da Silva","year":"2007","journal-title":"Brain Res. Bull."},{"key":"10.1016\/j.brainres.2016.04.073_bib9","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1146\/annurev.psych.53.100901.135148","article-title":"Depression: perspectives from affective neuroscience","volume":"53","author":"Davidson","year":"2002","journal-title":"Annu. Rev. Psychol."},{"issue":"16","key":"10.1016\/j.brainres.2016.04.073_bib10","doi-asserted-by":"crossref","first-page":"3489","DOI":"10.1097\/00001756-199711100-00015","article-title":"The lateral hypothalamus in the modulation of tonic immobility in guinea pigs","volume":"8","author":"De Oliveira","year":"1997","journal-title":"Neuroreport"},{"key":"10.1016\/j.brainres.2016.04.073_bib11","doi-asserted-by":"crossref","first-page":"1085","DOI":"10.1016\/S0306-4522(01)00150-6","article-title":"When a rat smells a cat: the distribution of fos immunoreactivity in rat brain following exposure to a predatory odor","volume":"104","author":"Dielenberg","year":"2001","journal-title":"Neuroscience"},{"key":"10.1016\/j.brainres.2016.04.073_bib12","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1016\/j.brainresbull.2009.04.016","article-title":"GABAergic antagonist blocks the reduction of tonic immobility behavior induced by activation of 5-HT2 receptors in the basolateral nucleus of the amygdala in guinea pigs","volume":"79","author":"Donatti","year":"2009","journal-title":"Brain Res. Bull."},{"key":"10.1016\/j.brainres.2016.04.073_bib13","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.brainres.2009.06.030","article-title":"Role of dorsal raphe nucleus 5-HT(1A) and 5-HT(2) receptors in tonic immobility modulation in guinea pigs","volume":"1285","author":"Ferreira","year":"2009","journal-title":"Brain Res."},{"issue":"1","key":"10.1016\/j.brainres.2016.04.073_bib14","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/j.jad.2007.07.015","article-title":"Peritraumatic tonic immobility predicts a poor response to pharmacological treatment in victims of urban violence with PTSD","volume":"107","author":"Fiszman","year":"2008","journal-title":"J. Affect. Disord."},{"key":"10.1016\/j.brainres.2016.04.073_bib15","doi-asserted-by":"crossref","first-page":"1067","DOI":"10.1016\/S0306-4522(01)00157-9","article-title":"Monoaminergic innervation of the macaque extended amygdala","volume":"104","author":"Freedman","year":"2001","journal-title":"Neuroscience"},{"key":"10.1016\/j.brainres.2016.04.073_bib16","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1007\/BF03394432","article-title":"Tonic immobility: the role of fear and predation","volume":"1","author":"Gallup","year":"1977","journal-title":"Psychol. Rec."},{"issue":"1\u20132","key":"10.1016\/j.brainres.2016.04.073_bib17","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/0006-8993(96)00517-3","article-title":"5-HT1A and benzodiazepine receptors in the basolateral amygdala modulate anxiety in the social interaction test, but not in the elevated plus-maze","volume":"732","author":"Gonzalez","year":"1996","journal-title":"Brain Res."},{"issue":"4","key":"10.1016\/j.brainres.2016.04.073_bib19","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1111\/j.1476-5381.1996.tb15241.x","article-title":"A receptor autoradiographic and in situ hybridization analysis of the distribution of the 5-HT7 receptor in rat brain","volume":"117","author":"Gustafson","year":"1996","journal-title":"Br. J. Pharmacol."},{"issue":"2","key":"10.1016\/j.brainres.2016.04.073_bib20","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1037\/0735-7044.109.2.295","article-title":"Effects of benzodiazepine microinjection into the amygdala or periaqueductal gray on the expression of conditioned fear and hypoalgesia in rats","volume":"109","author":"Harris","year":"1995","journal-title":"Behav. Neurosci."},{"issue":"1\u20133","key":"10.1016\/j.brainres.2016.04.073_bib21","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/j.ejphar.2004.01.031","article-title":"8-OH-DPAT acts on both 5-HT1A and 5-HT7 receptors to induce hypothermia in rodents","volume":"487","author":"Hedlund","year":"2004","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.brainres.2016.04.073_bib22","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/j.neubiorev.2005.06.007","article-title":"Serotonergic modulation of the limbic system","volume":"30","author":"Hensler","year":"2006","journal-title":"Neurosci. Biobehav. Rev."},{"key":"10.1016\/j.brainres.2016.04.073_bib24","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1007\/BF00176484","article-title":"Evidence that the amygdala is involved in benzodiazepine and serotonergic effects on punished responding but not on discrimination","volume":"92","author":"Hodges","year":"1987","journal-title":"Psychopharmacol."},{"key":"10.1016\/j.brainres.2016.04.073_bib25","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.neubiorev.2014.03.012","article-title":"The serotonin-BDNF duo: developmental implications for the vulnerability to psychopathology","volume":"43","author":"Homberg","year":"2014","journal-title":"Neurosci. Biobehav. Rev."},{"key":"10.1016\/j.brainres.2016.04.073_bib26","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1016\/S0091-3057(01)00745-6","article-title":"The medical benefit of 5-HT research","volume":"71","author":"Jones","year":"2002","journal-title":"Pharmacol. Biochem. Behav."},{"key":"10.1016\/j.brainres.2016.04.073_bib27","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/B978-0-12-512504-8.50011-1","article-title":"Neurophysiologic studies of the immobility reflex (\u201cAnimal hypnosis\u201d)","volume":"4","author":"Klemm","year":"1971","journal-title":"Neurosci. Res."},{"key":"10.1016\/j.brainres.2016.04.073_bib28","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1016\/S0301-0082(01)00016-8","article-title":"Behavioral arrest: in search of the neural control system","volume":"65","author":"Klemm","year":"2001","journal-title":"Prog. Neurobiol."},{"issue":"6","key":"10.1016\/j.brainres.2016.04.073_bib29","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1016\/j.npep.2013.10.014","article-title":"Role of neuropeptides in anxiety, stress, and depression: from animals to humans","volume":"47","author":"Kormos","year":"2013","journal-title":"Neuropeptides"},{"issue":"1\u20133","key":"10.1016\/j.brainres.2016.04.073_bib30","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/0014-2999(96)00180-X","article-title":"Molecular modeling of serotonin, ketanserin, ritanserin and their 5-HT2C receptor interactions","volume":"306","author":"Kristiansen","year":"1996","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.brainres.2016.04.073_bib31","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1146\/annurev.neuro.23.1.155","article-title":"Emotion circuits in the brain","volume":"23","author":"Ledoux","year":"2000","journal-title":"Annu. Rev. Neurosci."},{"key":"10.1016\/j.brainres.2016.04.073_bib32","series-title":"Advances in Zoology Reseach","first-page":"172","article-title":"Functional activation of the amygdaloid nuclei during conditioned and unconditioned fear: morphological bases of manually-induced tonic immobility response and spontaneous freezing behaviour evoked by guinea pigs confronted with constrictor snakes","author":"Leite-Panissi","year":"2012"},{"key":"10.1016\/j.brainres.2016.04.073_bib33","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1016\/j.brainresbull.2006.02.007","article-title":"Serotoninergic activation of the basolateral amygdala and modulation of tonic immobility in guinea pig","volume":"69","author":"Leite-Panissi","year":"2006","journal-title":"Brain Res. Bull."},{"key":"10.1016\/j.brainres.2016.04.073_bib34","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/S0361-9230(02)00748-7","article-title":"Central nucleus of the amygdala and the control of tonic immobility in guinea pigs","volume":"58","author":"Leite-Panissi","year":"2002","journal-title":"Brain Res. Bull."},{"key":"10.1016\/j.brainres.2016.04.073_bib35","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/S0361-9230(03)00031-5","article-title":"The cholinergic stimulation of the central amygdala modifying the tonic immobility response and antinociception in guinea pigs depends on the ventrolateral periaqueductal gray","volume":"60","author":"Leite-Panissi","year":"2003","journal-title":"Brain Res. Bull."},{"issue":"2","key":"10.1016\/j.brainres.2016.04.073_bib36","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1037\/0735-7044.118.2.324","article-title":"Medial amygdale modulation of predador odor-induced uncontidioned fear in the rat","volume":"118","author":"Li","year":"2004","journal-title":"Behav. Neurosci."},{"issue":"4","key":"10.1016\/j.brainres.2016.04.073_bib37","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1016\/j.jpsychires.2009.08.005","article-title":"The impact of tonic immobility reaction on the prognosis of posttraumatic stress disorder","volume":"44","author":"Lima","year":"2010","journal-title":"J. Psychiatr. Res."},{"key":"10.1016\/j.brainres.2016.04.073_bib38","series-title":"Handbook of the Behavioral Neurobiology of Serotonin","first-page":"163","article-title":"Electrophysiology of serotonin receptors","author":"Marek","year":"2010"},{"key":"10.1016\/j.brainres.2016.04.073_bib39","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1016\/j.neuroscience.2010.10.033","article-title":"Amygdalar roles during exposure to a live predator and to a predator-associated context","volume":"172","author":"Martinez","year":"2011","journal-title":"Neuroscience"},{"key":"10.1016\/j.brainres.2016.04.073_bib40","first-page":"257","article-title":"Cortical pathways to the mammalian amygdale","volume":"55","author":"McDonald","year":"1998","journal-title":"Prog. Brain Res."},{"key":"10.1016\/j.brainres.2016.04.073_bib1441","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1016\/j.neuroscience.2007.01.047","article-title":"Neuronal localization of 5-HT type 2A receptor immunoreactivity in the rat basolateral amygdala","volume":"146","author":"McDonald","year":"2007","journal-title":"Neuroscience"},{"key":"10.1016\/j.brainres.2016.04.073_bib41","doi-asserted-by":"crossref","first-page":"3S","DOI":"10.1097\/00004714-198712001-00002","article-title":"Serotonergic neuronal systems: what their anatomic organization tell us about function","volume":"7","author":"Molliver","year":"1987","journal-title":"J. Clin. Psychopharmacol."},{"issue":"1\u20132","key":"10.1016\/j.brainres.2016.04.073_bib42","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1016\/S0006-8993(97)01115-3","article-title":"Opioid supraspinal analgesic synergy between the amygdala and periaqueductal gray in rats","volume":"779","author":"Pavlovic","year":"1998","journal-title":"Brain Res."},{"issue":"1\u20132","key":"10.1016\/j.brainres.2016.04.073_bib44","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/0169-328X(94)90223-2","article-title":"Distribution of the serotonin 5-HT2 receptor family mRNAs: comparison between 5-HT2A and 5-HT2C receptors","volume":"23","author":"Pompeiano","year":"1994","journal-title":"Brain Res. Mol. Brain Res."},{"key":"10.1016\/j.brainres.2016.04.073_bib45","series-title":"Handbook of Clinical and Experimental Hypnosis","first-page":"550","article-title":"Comparative aspects of hypnosis","author":"Ratner","year":"1967"},{"issue":"1","key":"10.1016\/j.brainres.2016.04.073_bib46","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1016\/j.jad.2008.09.005","article-title":"Is tonic immobility the core sign among conventional peritraumatic signs and symptoms listed for PTSD?","volume":"115","author":"Rocha-Rego","year":"2009","journal-title":"J. Affect. Disord."},{"key":"10.1016\/j.brainres.2016.04.073_bib47","series-title":"Stereotaktischer hirnatlas vom Meerschweinchen","author":"R\u00f6ssner","year":"1965"},{"issue":"2","key":"10.1016\/j.brainres.2016.04.073_bib48","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/0165-3806(95)00055-I","article-title":"Ontogenetic development of histamine receptor subtypes in rat brain demonstrated by quantitative autoradiography","volume":"87","author":"Ryu","year":"1995","journal-title":"Brain Res. Dev. Brain Res."},{"key":"10.1016\/j.brainres.2016.04.073_bib49","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1016\/0306-4522(90)90439-B","article-title":"The monoaminergic innervation of the amygdala in the squirrel monkey: an immunocytochemical study","volume":"36","author":"Sadikot","year":"1990","journal-title":"Neuroscience"},{"key":"10.1016\/j.brainres.2016.04.073_bib50","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1152\/physrev.00002.2003","article-title":"The amygdaloid complex: anatomy and physiology","volume":"83","author":"Sah","year":"2003","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.brainres.2016.04.073_bib51","doi-asserted-by":"crossref","first-page":"108","DOI":"10.2307\/2424542","article-title":"Death feigning by ducks in response to predation by red foxes (vulpes fulva)","volume":"94","author":"Sargent","year":"1975","journal-title":"Am. Midl. Nat."},{"key":"10.1016\/j.brainres.2016.04.073_bib52","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1016\/0306-4522(81)90146-9","article-title":"Distribution of serotonin-immunoreactivity in the central nervous system of the rat \u2013 cell bodies and terminals","volume":"6","author":"Steinbusch","year":"1981","journal-title":"Neuroscience"},{"key":"10.1016\/j.brainres.2016.04.073_bib53","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.bbr.2013.03.005","article-title":"Activation of 5-HT1A receptors in the rat basolateral amygdala induces both anxiolytic and antipanic-like effects","volume":"246","author":"Strauss","year":"2013","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.brainres.2016.04.073_bib54","doi-asserted-by":"crossref","first-page":"145","DOI":"10.3758\/BF03212037","article-title":"Tonic immobility in Japanese quail can reduced the probability of sustained attack by cats","volume":"9","author":"Thompson","year":"1981","journal-title":"Anim. Learn. Behav."},{"key":"10.1016\/j.brainres.2016.04.073_bib55","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1016\/j.bbr.2010.07.013","article-title":"Funcional mapping of the periaqueductal gray matter involved in organizing tonic immobility behavior in guinea pigs","volume":"216","author":"Vieira","year":"2011","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.brainres.2016.04.073_bib56","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/0147-7552(77)90039-0","article-title":"A serotonergic, midbrain-raphe model of tonic immobility","volume":"1","author":"Wallnau","year":"1977","journal-title":"Biobehav. Rev."},{"issue":"14","key":"10.1016\/j.brainres.2016.04.073_bib57","doi-asserted-by":"crossref","first-page":"8423","DOI":"10.1016\/S0021-9258(17)39491-7","article-title":"Photoaffinity probes for serotonin and histamine receptors. Synthesis and characterization of two azide analogues of ketanserin","volume":"260","author":"Wouter","year":"1985","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.brainres.2016.04.073_bib58","first-page":"2453","article-title":"Behavioral effects of intra-amygdala injections of GABA and 5-HT acting drugs in the elevated plus-maze","volume":"27","author":"Zangrossi","year":"1994","journal-title":"Braz. J. MEd. Biol. Res."}],"container-title":["Brain Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006899316303304?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006899316303304?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2022,6,19]],"date-time":"2022-06-19T15:03:07Z","timestamp":1655650987000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006899316303304"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,7]]},"references-count":58,"alternative-id":["S0006899316303304"],"URL":"https:\/\/doi.org\/10.1016\/j.brainres.2016.04.073","relation":{},"ISSN":["0006-8993"],"issn-type":[{"value":"0006-8993","type":"print"}],"subject":[],"published":{"date-parts":[[2016,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Distinct effect of 5-HT1A and 5-HT2A receptors in the medial nucleus of the amygdala on tonic immobility behavior","name":"articletitle","label":"Article Title"},{"value":"Brain Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.brainres.2016.04.073","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 Elsevier B.V.","name":"copyright","label":"Copyright"}]}}