{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T21:53:30Z","timestamp":1790805210768,"version":"4.1.0"},"reference-count":46,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2016,12,1]],"date-time":"2016-12-01T00:00:00Z","timestamp":1480550400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Brain Research"],"published-print":{"date-parts":[[2016,12]]},"DOI":"10.1016\/j.brainres.2016.09.043","type":"journal-article","created":{"date-parts":[[2016,10,16]],"date-time":"2016-10-16T16:57:46Z","timestamp":1476637066000},"page":"195-203","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":23,"special_numbering":"C","title":["The effect of pulsed electric fields on the electrotactic migration of human neural progenitor cells through the involvement of intracellular calcium signaling"],"prefix":"10.1016","volume":"1652","author":[{"given":"Hisamitsu","family":"Hayashi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fredrik","family":"Edin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hao","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helge","family":"Rask-Andersen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.brainres.2016.09.043_bib1","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1007\/s11010-013-1645-3","article-title":"Pulsed electric current induces the differentiation of human keratinocytes","volume":"379","author":"Arai","year":"2013","journal-title":"Mol. Cell Biochem."},{"key":"10.1016\/j.brainres.2016.09.043_bib2","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1007\/s12015-010-9171-0","article-title":"The influence of electric fields on hippocampal neural progenitor cells","volume":"6","author":"Ariza","year":"2010","journal-title":"Stem Cell Rev."},{"key":"10.1016\/j.brainres.2016.09.043_bib3","doi-asserted-by":"crossref","first-page":"3267","DOI":"10.1002\/jnr.22502","article-title":"A time-lapse and quantitative modelling analysis of neural stem cell motion in the absence of directional cues and in electric fields","volume":"88","author":"Arocena","year":"2010","journal-title":"J. Neurosci. Res."},{"key":"10.1016\/j.brainres.2016.09.043_bib4","doi-asserted-by":"crossref","first-page":"e23808","DOI":"10.1371\/journal.pone.0023808","article-title":"Adult subependymal neural precursors, but not differentiated cells, undergo rapid cathodal migration in the presence of direct current electric fields","volume":"6","author":"Babona-Pilipos","year":"2011","journal-title":"PLoS One"},{"key":"10.1016\/j.brainres.2016.09.043_bib5","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1186\/s13287-015-0049-6","article-title":"Biphasic monopolar electrical stimulation induces rapid and directed galvanotaxis in adult subependymal neural precursors","volume":"6","author":"Babona-Pilipos","year":"2015","journal-title":"Stem Cell Res Ther."},{"key":"10.1016\/j.brainres.2016.09.043_bib6","doi-asserted-by":"crossref","first-page":"1234","DOI":"10.1161\/01.ATV.0000131265.76828.8a","article-title":"DC electric fields induce distinct preangiogenic responses in microvascular and macrovascular cells","volume":"24","author":"Bai","year":"2004","journal-title":"Arterioscler Thromb. Vasc. Biol."},{"key":"10.1016\/j.brainres.2016.09.043_bib7","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1002\/aja.1002030408","article-title":"Uncoupling histogenesis from morphogenesis in the vertebrate embryo by collapse of the transneural tube potential","volume":"203","author":"Borgens","year":"1995","journal-title":"Dev. Dyn."},{"key":"10.1016\/j.brainres.2016.09.043_bib8","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1096\/fasebj.1.5.3678699","article-title":"Electric stimulation of protein and DNA synthesis in human fibroblasts","volume":"1","author":"Bourguignon","year":"1987","journal-title":"FASEB J."},{"key":"10.1016\/j.brainres.2016.09.043_bib9","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1080\/03008200701424451","article-title":"Effects of applied DC electric field on ligament fibroblast migration and wound healing","volume":"48","author":"Chao","year":"2007","journal-title":"Connect Tissue Res."},{"key":"10.1016\/j.brainres.2016.09.043_bib10","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1114\/1.263","article-title":"Integrin-dependent human macrophage migration induced by oscillatory electrical stimulation","volume":"28","author":"Cho","year":"2000","journal-title":"Ann. Biomed. Eng."},{"key":"10.1016\/j.brainres.2016.09.043_bib11","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1073\/pnas.81.1.160","article-title":"Perpendicular orientation and directional migration of amphibian neural crest cells in dc electrical fields","volume":"81","author":"Cooper","year":"1984","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.brainres.2016.09.043_bib12","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1039\/C4IB00142G","article-title":"Influence of electrotaxis on cell behaviour","volume":"6","author":"Cortese","year":"2014","journal-title":"Integr. Biol. (Camb.)"},{"key":"10.1016\/j.brainres.2016.09.043_bib13","doi-asserted-by":"crossref","first-page":"1967","DOI":"10.1242\/jcs.112.12.1967","article-title":"Epidermal growth factor recep-tor relocalization and kinase activity are necessary for directional migration ofkeratinocytes in DC electric fields","volume":"112","author":"Fang","year":"1999","journal-title":"J. Cell Sci."},{"key":"10.1016\/j.brainres.2016.09.043_bib14","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1002\/stem.779","article-title":"Guided migration of neural stem cells derived from human embryonic stem cells by an electric field","volume":"30","author":"Feng","year":"2012","journal-title":"Stem Cells"},{"key":"10.1016\/j.brainres.2016.09.043_bib15","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1007\/s12015-011-9320-0","article-title":"The convergence of cochlear implantation with induced pluripotent stem cell therapy","volume":"8","author":"Gunewardene","year":"2012","journal-title":"Stem Cell Rev."},{"key":"10.1016\/j.brainres.2016.09.043_bib16","doi-asserted-by":"crossref","first-page":"2320","DOI":"10.1038\/jid.2010.96","article-title":"Effects of physiological electric fields on migration of human dermal fibroblasts","volume":"130","author":"Guo","year":"2010","journal-title":"J. Invest Dermatol."},{"key":"10.1016\/j.brainres.2016.09.043_bib17","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1016\/j.ceca.2008.11.003","article-title":"2-Aminoethoxydiphenyl-borate (2-APB) increases excitability in pyramidal neurons","volume":"45","author":"Hagenston","year":"2009","journal-title":"Cell Calcium"},{"key":"10.1016\/j.brainres.2016.09.043_bib18","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1016\/j.tcb.2004.04.006","article-title":"Guiding neuronal growth cones using Ca2+ signals","volume":"14","author":"Henley","year":"2004","journal-title":"Trends Cell Biol."},{"key":"10.1016\/j.brainres.2016.09.043_bib19","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/0012-1606(90)90062-N","article-title":"Endogenous electrical currents and the resultant voltage gradients in the chick embryo","volume":"140","author":"Hotary","year":"1990","journal-title":"Dev. Biol."},{"key":"10.1016\/j.brainres.2016.09.043_bib20","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/0165-3806(91)90030-M","article-title":"The neural tube of the Xenopus embryo maintains a potential difference across itself","volume":"59","author":"Hotary","year":"1991","journal-title":"Brain Res. Dev. Brain Res."},{"key":"10.1016\/j.brainres.2016.09.043_bib21","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1006\/dbio.1994.1357","article-title":"Endogenous electrical currents and voltage gradients in Xenopus embryos and the consequences of their disruption","volume":"166","author":"Hotary","year":"1994","journal-title":"Dev. Biol."},{"key":"10.1016\/j.brainres.2016.09.043_bib22","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/S0092-8674(00)80956-3","article-title":"Identification of a neural stem cell in the adult mammalian central nervous system","volume":"96","author":"Johansson","year":"1999","journal-title":"Cell"},{"key":"10.1016\/j.brainres.2016.09.043_bib23","doi-asserted-by":"crossref","first-page":"1293","DOI":"10.1038\/nm925","article-title":"Pluripotent stem cells from the adult mouse inner ear","volume":"9","author":"Li","year":"2003","journal-title":"Nat. Med."},{"key":"10.1016\/j.brainres.2016.09.043_bib24","doi-asserted-by":"crossref","first-page":"2193","DOI":"10.1634\/stemcells.2007-1022","article-title":"Direct-current electrical field guides neuronal stem\/progenitor cell migration","volume":"26","author":"Li","year":"2008","journal-title":"Stem Cells"},{"key":"10.1016\/j.brainres.2016.09.043_bib25","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1007\/s12015-014-9518-z","article-title":"Directed migration of embryonic stem cell-derived neural cells in an applied electric field","volume":"10","author":"Li","year":"2014","journal-title":"Stem Cell Rev."},{"key":"10.1016\/j.brainres.2016.09.043_bib26","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1016\/j.biocel.2014.09.014","article-title":"Electric field regulated signaling pathways","volume":"55","author":"Liu","year":"2014","journal-title":"Int J. Biochem Cell Biol."},{"key":"10.1016\/j.brainres.2016.09.043_bib27","series-title":"Directional Statistics","author":"Mardia","year":"2000"},{"key":"10.1016\/j.brainres.2016.09.043_bib28","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1093\/oxfordjournals.jbchem.a021780","article-title":"2APB, 2-aminoethoxydiphenyl borate, a membrane-penetrable modulator of Ins(1,4,5)P3-induced Ca2+ release","volume":"22","author":"Maruyama","year":"1997","journal-title":"J. Biochem"},{"key":"10.1016\/j.brainres.2016.09.043_bib29","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1042\/bj2710515","article-title":"SK&F 96365, a novel inhibitor of receptor-mediated calcium entry","volume":"271","author":"Merritt","year":"1990","journal-title":"Biochem J."},{"key":"10.1016\/j.brainres.2016.09.043_bib30","doi-asserted-by":"crossref","first-page":"1631","DOI":"10.1242\/jcs.01125","article-title":"Cellular mechanisms of direct-current electric field effects: galvanotaxis and metastatic disease","volume":"117","author":"Mycielska","year":"2004","journal-title":"J. Cell Sci."},{"key":"10.1016\/j.brainres.2016.09.043_bib31","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1007\/s10162-006-0058-3","article-title":"Differential distribution of stem cells in the auditory and vestibular organs of the inner ear","volume":"8","author":"Oshima","year":"2007","journal-title":"JARO"},{"key":"10.1016\/j.brainres.2016.09.043_bib32","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1046\/j.1523-1747.2003.12454.x","article-title":"Electrical stimulation of wound healing","volume":"121","author":"Ojingwa","year":"2003","journal-title":"J. Invest Dermatol"},{"key":"10.1016\/j.brainres.2016.09.043_bib33","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1523\/JNEUROSCI.02-04-00483.1982","article-title":"Orientation of neurite growth by extracellular electric fields","volume":"2","author":"Patel","year":"1982","journal-title":"J. Neurosci."},{"key":"10.1016\/j.brainres.2016.09.043_bib34","doi-asserted-by":"crossref","first-page":"2939","DOI":"10.1523\/JNEUROSCI.04-12-02939.1984","article-title":"Perturbation of the direction of neurite growth by pulsed and focal electric fields","volume":"4","author":"Patel","year":"1984","journal-title":"J. Neurosci."},{"key":"10.1016\/j.brainres.2016.09.043_bib35","doi-asserted-by":"crossref","first-page":"602","DOI":"10.1038\/265602a0","article-title":"Electrophoresis of concanavalin A receptors along embryonic muscle cell membrane","volume":"265","author":"Poo","year":"1977","journal-title":"Nature"},{"key":"10.1016\/j.brainres.2016.09.043_bib36","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1113\/expphysiol.1992.sp003580","article-title":"Electric field-induced orientation of rat hippocampal neurones in vitro","volume":"77","author":"Rajnicek","year":"1992","journal-title":"Exp. Physiol."},{"key":"10.1016\/j.brainres.2016.09.043_bib37","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1016\/j.heares.2004.12.005","article-title":"Regeneration of human auditory nerve. In vitro\/in video demonstration of neural progenitor cells in adult human and guinea pig spiral ganglion","volume":"203","author":"Rask-Andersen","year":"2005","journal-title":"Hear. Res."},{"key":"10.1016\/j.brainres.2016.09.043_bib38","doi-asserted-by":"crossref","first-page":"2023","DOI":"10.1083\/jcb.101.6.2023","article-title":"The responses of cells to electrical fields: a review","volume":"101","author":"Robinson","year":"1985","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.brainres.2016.09.043_bib39","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1006\/dbio.1994.1238","article-title":"Embryonic neuroepithelial sodium transport, the resulting physiological potential, and cranial development","volume":"165","author":"Shi","year":"1994","journal-title":"Dev. Biol."},{"key":"10.1016\/j.brainres.2016.09.043_bib40","doi-asserted-by":"crossref","first-page":"1479","DOI":"10.1038\/nprot.2007.205","article-title":"Application of direct current electric fields to cells and tissues in vitro and modulation of wound electric field in vivo","volume":"2","author":"Song","year":"2007","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.brainres.2016.09.043_bib41","first-page":"2278","article-title":"Movements of cultured corneal epithelial cells and stromal fibroblasts in electric fields","volume":"31","author":"Soong","year":"1990","journal-title":"Invest Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.brainres.2016.09.043_bib42","first-page":"2090","article-title":"Controlling cellular biomechanics of human mesenchymal stem cells","volume":"2009","author":"Titushkin","year":"2009","journal-title":"Conf. Proc. IEEE Eng. Med Biol. Soc."},{"key":"10.1016\/j.brainres.2016.09.043_bib43","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1039\/C0LC00155D","article-title":"Asymmetric cancer-cell filopodium growth induced by electric-fields in a microfluidic culture chip","volume":"11","author":"Wang","year":"2011","journal-title":"Lab Chip"},{"key":"10.1016\/j.brainres.2016.09.043_bib44","doi-asserted-by":"crossref","first-page":"1115","DOI":"10.1007\/s12013-013-9615-7","article-title":"DC electric fields direct breast cancer cell migration, induce EGFRpolarization, and increase the intracellular level of calcium ions","volume":"67","author":"Wu","year":"2013","journal-title":"Cell Biochem Biophys."},{"key":"10.1016\/j.brainres.2016.09.043_bib45","doi-asserted-by":"crossref","first-page":"1259","DOI":"10.1091\/mbc.10.4.1259","article-title":"Electric field-directed cell motility involves up-regulated expression and asymmetric redistribution of the epidermal growthfactor receptors and is enhanced by fibronectin and laminin","volume":"10","author":"Zhao","year":"1999","journal-title":"Mol. Biol. Cell"},{"key":"10.1016\/j.brainres.2016.09.043_bib46","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1038\/nature04925","article-title":"Electrical signals control woundhealing through phosphatidylinositol-3-OH kinase-gamma and PTEN","volume":"442","author":"Zhao","year":"2006","journal-title":"Nature"}],"container-title":["Brain Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006899316306886?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006899316306886?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2022,7,10]],"date-time":"2022-07-10T09:35:20Z","timestamp":1657445720000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006899316306886"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,12]]},"references-count":46,"alternative-id":["S0006899316306886"],"URL":"https:\/\/doi.org\/10.1016\/j.brainres.2016.09.043","relation":{},"ISSN":["0006-8993"],"issn-type":[{"value":"0006-8993","type":"print"}],"subject":[],"published":{"date-parts":[[2016,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The effect of pulsed electric fields on the electrotactic migration of human neural progenitor cells through the involvement of intracellular calcium signaling","name":"articletitle","label":"Article Title"},{"value":"Brain Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.brainres.2016.09.043","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}