{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T18:45:04Z","timestamp":1792176304395,"version":"4.4.0"},"reference-count":43,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2016,12,1]],"date-time":"2016-12-01T00:00:00Z","timestamp":1480550400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100004731","name":"Natural Science Foundation of Zhejiang","doi-asserted-by":"crossref","award":["LY14H310002"],"award-info":[{"award-number":["LY14H310002"]}],"id":[{"id":"10.13039\/501100004731","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100004731","name":"Natural Science Foundation of Zhejiang","doi-asserted-by":"crossref","award":["81471350"],"award-info":[{"award-number":["81471350"]}],"id":[{"id":"10.13039\/501100004731","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100004731","name":"Natural Science Foundation of Zhejiang","doi-asserted-by":"crossref","award":["81671321"],"award-info":[{"award-number":["81671321"]}],"id":[{"id":"10.13039\/501100004731","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100012166","name":"National Basic Research Program of China","doi-asserted-by":"crossref","award":["2015CB553504"],"award-info":[{"award-number":["2015CB553504"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Science and Technology Program of Ningbo","award":["2013C50033"],"award-info":[{"award-number":["2013C50033"]}]},{"name":"Science and Technology Program of Ningbo","award":["2015C110026"],"award-info":[{"award-number":["2015C110026"]}]}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Brain Research"],"published-print":{"date-parts":[[2016,12]]},"DOI":"10.1016\/j.brainres.2016.10.007","type":"journal-article","created":{"date-parts":[[2016,10,15]],"date-time":"2016-10-15T12:43:56Z","timestamp":1476535436000},"page":"151-157","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":44,"special_numbering":"C","title":["Effects of histone deacetylase inhibitor sodium butyrate on heroin seeking behavior in the nucleus accumbens in rats"],"prefix":"10.1016","volume":"1652","author":[{"given":"Wei-Sheng","family":"Chen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen-Jin","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hua-Qiang","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miao-Jun","family":"Lai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fu-Qiang","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen-Hua","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui-Fen","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.brainres.2016.10.007_bib1","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1016\/j.neuropharm.2012.12.007","article-title":"Alcohol intoxications during adolescence increase motivation for alcohol in adult rats and induce neuroadaptations in the nucleus accumbens","volume":"67","author":"Alaux-Cantin","year":"2013","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.brainres.2016.10.007_bib2","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1101\/lm.917508","article-title":"Beyond transcription factors: the role of chromatin modifying enzymes in regulating transcription required for memory","volume":"15","author":"Barrett","year":"2008","journal-title":"Learn Mem."},{"key":"10.1016\/j.brainres.2016.10.007_bib3","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1038\/nature05913","article-title":"Perceptions of epigenetics","volume":"447","author":"Bird","year":"2007","journal-title":"Nature"},{"key":"10.1016\/j.brainres.2016.10.007_bib4","doi-asserted-by":"crossref","first-page":"e0124796","DOI":"10.1371\/journal.pone.0124796","article-title":"Inhibition of histone deacetylases facilitates extinction and attenuates reinstatement of nicotine self-administration in rats","volume":"10","author":"Castino","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.brainres.2016.10.007_bib5","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1007\/s002800050922","article-title":"Plasma pharmacokinetics of butyrate after intravenous administration of sodium butyrate or oral administration of tributyrin or sodium butyrate to mice and rats","volume":"43","author":"Egorin","year":"1999","journal-title":"Cancer Chemother. Pharmacol."},{"key":"10.1016\/j.brainres.2016.10.007_bib6","doi-asserted-by":"crossref","first-page":"616","DOI":"10.1097\/00006123-200103000-00035","article-title":"Therapeutic effects of sodium butyrate on glioma cells in vitro and in the rat C6 glioma model","volume":"48","author":"Engelhard","year":"2001","journal-title":"Neurosurgery"},{"key":"10.1016\/j.brainres.2016.10.007_bib7","doi-asserted-by":"crossref","first-page":"39","DOI":"10.3389\/fnmol.2015.00039","article-title":"Repeated vapor ethanol exposure induces transient histone modifications in the brain that are modified by genotype and brain region","volume":"8","author":"Finegersh","year":"2015","journal-title":"Front. Mol. Neurosci."},{"key":"10.1016\/j.brainres.2016.10.007_bib8","doi-asserted-by":"crossref","DOI":"10.1093\/ijnp\/pyv029","article-title":"The class I-Specific HDAC inhibitor MS-275 decreases motivation to consume alcohol and relapse in heavy drinking rats","volume":"18","author":"Jeanblanc","year":"2015","journal-title":"Int. J. Neuropsychopharmacol."},{"key":"10.1016\/j.brainres.2016.10.007_bib9","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/j.neulet.2011.03.005","article-title":"Effect of the histone deacetylase inhibitors on behavioural sensitization to a single morphine exposure in mice","volume":"494","author":"Jing","year":"2011","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.brainres.2016.10.007_bib10","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/j.bbr.2007.03.027","article-title":"Histone deacetylase inhibitors modulates the induction and expression of amphetamine-induced behavioral sensitization partially through an associated learning of the environment in mice","volume":"181","author":"Kalda","year":"2007","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.brainres.2016.10.007_bib11","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1016\/j.neuron.2005.09.023","article-title":"Chromatin remodeling is a key mechanism underlying cocaine-induced plasticity in striatum","volume":"48","author":"Kumar","year":"2005","journal-title":"Neuron"},{"key":"10.1016\/j.brainres.2016.10.007_bib12","doi-asserted-by":"crossref","first-page":"1397","DOI":"10.1017\/S1461145714000595","article-title":"The phosphodiesterase-4 inhibitor rolipram attenuates heroin-seeking behavior induced by cues or heroin priming in rats","volume":"17","author":"Lai","year":"2014","journal-title":"Int. J. Neuropsychopharmacol."},{"issue":"9","key":"10.1016\/j.brainres.2016.10.007_bib13","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1017\/S1461145714000595","article-title":"The phosphodiesterase-4 inhibitor rolipram attenuates heroin-seeking behavior induced by cues or heroin priming in rats","volume":"17","author":"Lai","year":"2014","journal-title":"Int. J. Neuropsychopharmacol."},{"key":"10.1016\/j.brainres.2016.10.007_bib14","doi-asserted-by":"crossref","first-page":"1143","DOI":"10.1111\/acer.12088","article-title":"Blockade of ethanol-induced behavioral sensitization by sodium butyrate: descriptive analysis of gene regulations in the striatum","volume":"37","author":"Legastelois","year":"2013","journal-title":"Alcohol. Clin. Exp. Res"},{"issue":"8","key":"10.1016\/j.brainres.2016.10.007_bib15","doi-asserted-by":"crossref","first-page":"2515","DOI":"10.1016\/j.neuropharm.2012.01.031","article-title":"Galantamine attenuates the heroin seeking behaviors induced by cues after prolonged withdrawal in rats","volume":"62","author":"Liu","year":"2012","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.brainres.2016.10.007_bib16","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/j.neulet.2011.02.059","article-title":"Vagus nerve stimulation inhibits heroin-seeking behavior induced by heroin priming or heroin-associated cues in rats","volume":"494","author":"Liu","year":"2011","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.brainres.2016.10.007_bib17","doi-asserted-by":"crossref","first-page":"1485","DOI":"10.1038\/aps.2014.93","article-title":"Blockade of mGluR5 in the nucleus accumbens shell but not core attenuates heroin seeking behavior in rats","volume":"35","author":"Lou","year":"2014","journal-title":"Acta Pharmacol. Sin."},{"key":"10.1016\/j.brainres.2016.10.007_bib18","doi-asserted-by":"crossref","first-page":"e34236","DOI":"10.1371\/journal.pone.0034236","article-title":"Methamphetamine causes differential alterations in gene expression and patterns of histone acetylation\/hypoacetylation in the rat nucleus accumbens","volume":"7","author":"Martin","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.brainres.2016.10.007_bib19","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1007\/s11920-010-0099-5","article-title":"Epigenetic regulation in substance use disorders","volume":"12","author":"McQuown","year":"2010","journal-title":"Curr. Psychiatry Rep."},{"key":"10.1016\/j.brainres.2016.10.007_bib20","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1016\/j.neuropharm.2013.04.004","article-title":"Epigenetic mechanisms of drug addiction","volume":"76","author":"Nestler","year":"2014","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.brainres.2016.10.007_bib21","doi-asserted-by":"crossref","first-page":"3729","DOI":"10.1523\/JNEUROSCI.5731-07.2008","article-title":"Brain chromatin remodeling: a novel mechanism of alcoholism","volume":"28","author":"Pandey","year":"2008","journal-title":"J. Neurosci."},{"key":"10.1016\/j.brainres.2016.10.007_bib22","doi-asserted-by":"crossref","first-page":"2309","DOI":"10.1016\/j.neuropharm.2012.01.011","article-title":"Changes in histone acetylation in the prefrontal cortex of ethanol-exposed adolescent rats are associated with ethanol-induced place conditioning","volume":"62","author":"Pascual","year":"2012","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.brainres.2016.10.007_bib23","doi-asserted-by":"crossref","first-page":"7344","DOI":"10.1523\/JNEUROSCI.1043-08.2008","article-title":"Delta FosB mediates epigenetic desensitization of the c-fos gene after chronic amphetamine exposure","volume":"28","author":"Renthal","year":"2008","journal-title":"J. Neurosci."},{"key":"10.1016\/j.brainres.2016.10.007_bib24","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1016\/j.neuron.2009.03.026","article-title":"Genome-wide analysis of chromatin regulation by cocaine reveals a role for sirtuins","volume":"62","author":"Renthal","year":"2009","journal-title":"Neuron"},{"key":"10.1016\/j.brainres.2016.10.007_bib25","doi-asserted-by":"crossref","first-page":"4295","DOI":"10.1523\/JNEUROSCI.5192-12.2013","article-title":"Behavioral and structural responses to chronic cocaine require a feedforward loop involving DeltaFosB and calcium\/calmodulin-dependent protein kinase II in the nucleus accumbens shell","volume":"33","author":"Robison","year":"2013","journal-title":"J. Neurosci."},{"key":"10.1016\/j.brainres.2016.10.007_bib26","doi-asserted-by":"crossref","first-page":"21","DOI":"10.2174\/157015911795017317","article-title":"The inhibition of histone deacetylases reduces the reinstatement of cocaine-seeking behavior in rats","volume":"9","author":"Romieu","year":"2011","journal-title":"Curr. Neuropharmacol."},{"key":"10.1016\/j.brainres.2016.10.007_bib27","doi-asserted-by":"crossref","first-page":"1207","DOI":"10.1017\/S1461145714000054","article-title":"Effects of histone deacetylase inhibitors on amygdaloid histone acetylation and neuropeptide Y expression: a role in anxiety-like and alcohol-drinking behaviours","volume":"17","author":"Sakharkar","year":"2014","journal-title":"Int. J. Neuropsychopharmacol."},{"key":"10.1016\/j.brainres.2016.10.007_bib28","doi-asserted-by":"crossref","first-page":"2642","DOI":"10.1038\/npp.2009.125","article-title":"Selective boosting of transcriptional and behavioral responses to drugs of abuse by histone deacetylase inhibition","volume":"34","author":"Sanchis-Segura","year":"2009","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.brainres.2016.10.007_bib29","doi-asserted-by":"crossref","first-page":"2981","DOI":"10.1038\/npp.2008.15","article-title":"Drug-induced activation of dopamine D(1) receptor signaling and inhibition of class I\/II histone deacetylase induce chromatin remodeling in reward circuitry and modulate cocaine-related behaviors","volume":"33","author":"Schroeder","year":"2008","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.brainres.2016.10.007_bib30","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1097\/WNR.0b013e328348e6aa","article-title":"Histone H3 phosphoacetylation is critical for heroin-induced place preference","volume":"22","author":"Sheng","year":"2011","journal-title":"Neuroreport"},{"key":"10.1016\/j.brainres.2016.10.007_bib31","doi-asserted-by":"crossref","first-page":"1244","DOI":"10.1002\/syn.20947","article-title":"Enhancement of histone acetylation in midbrain of mice with ethanol physical dependence and its withdrawal","volume":"65","author":"Shibasaki","year":"2011","journal-title":"Synapse"},{"key":"10.1016\/j.brainres.2016.10.007_bib32","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1111\/adb.12161","article-title":"The histone deacetylase inhibitor sodium butyrate decreases excessive ethanol intake in dependent animals","volume":"20","author":"Simon-O\u2032Brien","year":"2015","journal-title":"Addict. Biol."},{"key":"10.1016\/j.brainres.2016.10.007_bib33","doi-asserted-by":"crossref","first-page":"2377","DOI":"10.1111\/acer.12502","article-title":"Histone acetylation in the nucleus accumbens shell modulates ethanol-induced locomotor activity in DBA\/2J mice","volume":"38","author":"Sprow","year":"2014","journal-title":"Alcohol. Clin. Exp. Res."},{"key":"10.1016\/j.brainres.2016.10.007_bib34","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/j.neulet.2008.05.010","article-title":"The effects of sodium butyrate, an inhibitor of histone deacetylase, on the cocaine- and sucrose-maintained self-administration in rats","volume":"441","author":"Sun","year":"2008","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.brainres.2016.10.007_bib35","doi-asserted-by":"crossref","first-page":"1016","DOI":"10.1016\/j.cell.2011.08.008","article-title":"Identification of 67 histone marks and histone lysine crotonylation as a new type of histone modification","volume":"146","author":"Tan","year":"2011","journal-title":"Cell"},{"key":"10.1016\/j.brainres.2016.10.007_bib36","doi-asserted-by":"crossref","first-page":"913","DOI":"10.1038\/npp.2009.193","article-title":"Chronic cocaine-induced H3 acetylation and transcriptional activation of CaMKIIalpha in the nucleus accumbens is critical for motivation for drug reinforcement","volume":"35","author":"Wang","year":"2010","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.brainres.2016.10.007_bib37","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1007\/s12031-014-0317-4","article-title":"Inhibition of histone deacetylase in the basolateral amygdala facilitates morphine context-associated memory formation in rats","volume":"55","author":"Wang","year":"2015","journal-title":"J. Mol. Neurosci."},{"key":"10.1016\/j.brainres.2016.10.007_bib38","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/j.ejphar.2014.03.040","article-title":"Epigenetic upregulation of PSD-95 contributes to the rewarding behavior by morphine conditioning","volume":"732","author":"Wang","year":"2014","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.brainres.2016.10.007_bib39","doi-asserted-by":"crossref","first-page":"897","DOI":"10.1038\/ng.154","article-title":"Combinatorial patterns of histone acetylations and methylations in the human genome","volume":"40","author":"Wang","year":"2008","journal-title":"Nat. Genet"},{"key":"10.1016\/j.brainres.2016.10.007_bib40","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1016\/j.brainres.2016.06.019","article-title":"Microinjection of histone deacetylase inhibitor into the ventrolateral orbital cortex potentiates morphine induced behavioral sensitization","volume":"1646","author":"Wei","year":"2016","journal-title":"Brain Res."},{"key":"10.1016\/j.brainres.2016.10.007_bib41","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1017\/S1461145713001144","article-title":"Reversal of deficits in dendritic spines, BDNF and Arc expression in the amygdala during alcohol dependence by HDAC inhibitor treatment","volume":"17","author":"You","year":"2014","journal-title":"Int. J. Neuropsychopharmacol."},{"key":"10.1016\/j.brainres.2016.10.007_bib42","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1016\/j.biopsych.2007.06.008","article-title":"N-acetylcysteine reduces extinction responding and induces enduring reductions in cue- and heroin-induced drug-seeking","volume":"63","author":"Zhou","year":"2008","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.brainres.2016.10.007_bib43","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1097\/00001756-200403220-00031","article-title":"Low dose of heroin inhibits drug-seeking elicited by cues after prolonged withdrawal from heroin self-administration in rats","volume":"15","author":"Zhou","year":"2004","journal-title":"Neuroreport"}],"container-title":["Brain Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006899316306990?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006899316306990?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,5,17]],"date-time":"2020-05-17T03:28:11Z","timestamp":1589686091000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006899316306990"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,12]]},"references-count":43,"alternative-id":["S0006899316306990"],"URL":"https:\/\/doi.org\/10.1016\/j.brainres.2016.10.007","relation":{},"ISSN":["0006-8993"],"issn-type":[{"value":"0006-8993","type":"print"}],"subject":[],"published":{"date-parts":[[2016,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Effects of histone deacetylase inhibitor sodium butyrate on heroin seeking behavior in the nucleus accumbens in rats","name":"articletitle","label":"Article Title"},{"value":"Brain Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.brainres.2016.10.007","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 Published by Elsevier B.V.","name":"copyright","label":"Copyright"}]}}