{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T12:33:43Z","timestamp":1778589223813,"version":"3.51.4"},"reference-count":48,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2017,3,1]],"date-time":"2017-03-01T00:00:00Z","timestamp":1488326400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Brain Research"],"published-print":{"date-parts":[[2017,3]]},"DOI":"10.1016\/j.brainres.2016.12.030","type":"journal-article","created":{"date-parts":[[2017,1,5]],"date-time":"2017-01-05T13:45:31Z","timestamp":1483623931000},"page":"1-10","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":10,"special_numbering":"C","title":["Dentate gyrus autonomous ictal activity in the status epilepticus rat model of epilepsy"],"prefix":"10.1016","volume":"1658","author":[{"given":"Florian","family":"Weissinger","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthias","family":"Wawra","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pawel","family":"Fidzinski","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mark","family":"Elsner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hartmut","family":"Meierkord","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martin","family":"Holtkamp","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katharina","family":"Buchheim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.brainres.2016.12.030_b0005","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/S0079-6123(07)63001-5","article-title":"The dentate gyrus: fundamental neuroanatomical organization (dentate gyrus for dummies)","volume":"163","author":"Amaral","year":"2007","journal-title":"Prog. Brain Res."},{"key":"10.1016\/j.brainres.2016.12.030_b0010","doi-asserted-by":"crossref","first-page":"10811","DOI":"10.1523\/JNEUROSCI.0388-11.2011","article-title":"Synaptic kainate receptors in interplay with INaP shift the sparse firing of dentate granule cells to a sustained rhythmic mode in temporal lobe epilepsy","volume":"31","author":"Artinian","year":"2011","journal-title":"J. Neurosci."},{"key":"10.1016\/j.brainres.2016.12.030_b0015","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/S0301-0082(02)00077-1","article-title":"Network and pharmacological mechanisms leading to epileptiform synchronization in the limbic system in vitro","volume":"68","author":"Avoli","year":"2002","journal-title":"Prog. Neurobiol."},{"key":"10.1016\/j.brainres.2016.12.030_b0020","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1523\/JNEUROSCI.17-01-00477.1997","article-title":"Changes in hippocampal circuitry after pilocarpine-induced seizures as revealed by opioid receptor distribution and activation","volume":"17","author":"Bausch","year":"1997","journal-title":"J. Neurosci."},{"key":"10.1016\/j.brainres.2016.12.030_b0025","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/0304-3940(96)13019-6","article-title":"Spread of low Mg2+ induced epileptiform activity from the rat entorhinal cortex to the hippocampus after kindling studied in vitro","volume":"216","author":"Behr","year":"1996","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.brainres.2016.12.030_b0030","doi-asserted-by":"crossref","first-page":"1726","DOI":"10.1152\/jn.1998.79.4.1726","article-title":"Enhanced propagation of epileptiform activity through the kindled dentate gyrus","volume":"79","author":"Behr","year":"1998","journal-title":"J. Neurophysiol."},{"key":"10.1016\/j.brainres.2016.12.030_b0035","doi-asserted-by":"crossref","first-page":"8312","DOI":"10.1523\/JNEUROSCI.19-19-08312.1999","article-title":"Human neuronal gamma-aminobutyric acid(A) receptors: coordinated subunit mRNA expression and functional correlates in individual dentate granule cells","volume":"19","author":"Brooks-Kayal","year":"1999","journal-title":"J. Neurosci."},{"key":"10.1016\/j.brainres.2016.12.030_b0040","doi-asserted-by":"crossref","first-page":"1877","DOI":"10.1046\/j.1460-9568.1999.00606.x","article-title":"Intrinsic optical signal measurements reveal characteristic features during different forms of spontaneous neuronal hyperactivity associated with ECS shrinkage in vitro","volume":"11","author":"Buchheim","year":"1999","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.brainres.2016.12.030_b0045","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1002\/cne.21801","article-title":"Minimal latency to hippocampal epileptogenesis and clinical epilepsy after perforant pathway stimulation-induced status epilepticus in awake rats","volume":"510","author":"Bumanglag","year":"2008","journal-title":"J. Comp. Neurol."},{"key":"10.1016\/j.brainres.2016.12.030_b0050","doi-asserted-by":"crossref","first-page":"1607","DOI":"10.1046\/j.1460-9568.2003.02597.x","article-title":"Dentate granule cell GABA(A) receptors in epileptic hippocampus: enhanced synaptic efficacy and altered pharmacology","volume":"17","author":"Cohen","year":"2003","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.brainres.2016.12.030_b0055","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/S0079-6123(07)63014-3","article-title":"Functional regulation of the dentate gyrus by GABA-mediated inhibition","volume":"163","author":"Coulter","year":"2007","journal-title":"Prog. Brain Res."},{"key":"10.1016\/j.brainres.2016.12.030_b0060","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1016\/0014-4886(90)90072-Z","article-title":"Sprouting of GABAergic and mossy fiber axons in dentate gyrus following intrahippocampal kainate in the rat","volume":"109","author":"Davenport","year":"1990","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.brainres.2016.12.030_b0065","doi-asserted-by":"crossref","first-page":"7873","DOI":"10.1523\/JNEUROSCI.23-21-07873.2003","article-title":"Transition from interictal to ictal activity in limbic networks in vitro","volume":"23","author":"Dzhala","year":"2003","journal-title":"J. Neurosci."},{"key":"10.1016\/j.brainres.2016.12.030_b0070","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1002\/(SICI)1096-9861(19990927)412:3<488::AID-CNE8>3.0.CO;2-6","article-title":"Up-regulation of GAD65 and GAD67 in remaining hippocampal GABA neurons in a model of temporal lobe epilepsy","volume":"412","author":"Esclapez","year":"1999","journal-title":"J. Comp. Neurol."},{"key":"10.1016\/j.brainres.2016.12.030_b0075","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1016\/S0197-0186(99)00040-6","article-title":"GABAergic neurons and GABA(A)-receptors in temporal lobe epilepsy","volume":"34","author":"Fritschy","year":"1999","journal-title":"Neurochem. Int."},{"key":"10.1016\/j.brainres.2016.12.030_b0080","doi-asserted-by":"crossref","first-page":"2139","DOI":"10.1152\/jn.1997.77.4.2139","article-title":"Physiological and pharmacological alterations in postsynaptic GABA(A) receptor function in a hippocampal culture model of chronic spontaneous seizures","volume":"77","author":"Gibbs","year":"1997","journal-title":"J. Neurophysiol."},{"key":"10.1016\/j.brainres.2016.12.030_b0085","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1046\/j.1460-9568.2002.02108.x","article-title":"Differential and long-lasting alterations of high-voltage activated calcium currents in CA1 and dentate granule neurons after status epilepticus","volume":"16","author":"Gorter","year":"2002","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.brainres.2016.12.030_b0090","doi-asserted-by":"crossref","first-page":"561","DOI":"10.5194\/npg-11-561-2004","article-title":"Application of the cross wavelet transform and wavelet coherence to geophysical time series","volume":"11","author":"Grinsted","year":"2004","journal-title":"Nonlinear Process Geophys."},{"key":"10.1016\/j.brainres.2016.12.030_b0095","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1016\/S0006-8993(98)01102-0","article-title":"Epileptiform activity induced by low Mg2+ in cultured rat hippocampal slices","volume":"815","author":"Gutierrez","year":"1999","journal-title":"Brain Res."},{"key":"10.1016\/j.brainres.2016.12.030_b0100","first-page":"273","article-title":"The dentate gyrus as a regulated gate for the propagation of epileptiform activity","volume":"7","author":"Heinemann","year":"1992","journal-title":"Epilepsy Res. Suppl."},{"key":"10.1016\/j.brainres.2016.12.030_b0105","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1038\/9142","article-title":"Deficit of quantal release of GABA in experimental models of temporal lobe epilepsy","volume":"2","author":"Hirsch","year":"1999","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.brainres.2016.12.030_b0110","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1016\/j.nbd.2011.03.014","article-title":"Status epilepticus induces increasing neuronal excitability and hypersynchrony as revealed by optical imaging","volume":"43","author":"Holtkamp","year":"2011","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.brainres.2016.12.030_b0115","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1016\/j.nbd.2004.12.002","article-title":"Transient loss of inhibition precedes spontaneous seizures after experimental status epilepticus","volume":"19","author":"Holtkamp","year":"2005","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.brainres.2016.12.030_b0120","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1016\/S0079-6123(07)63032-5","article-title":"The dentate gyrus as a filter or gate: a look back and a look ahead","volume":"163","author":"Hsu","year":"2007","journal-title":"Prog. Brain Res."},{"key":"10.1016\/j.brainres.2016.12.030_b0125","doi-asserted-by":"crossref","first-page":"1476","DOI":"10.1152\/jn.1988.59.5.1476","article-title":"Synaptic and intrinsic responses of medical entorhinal cortical cells in normal and magnesium-free medium in vitro","volume":"59","author":"Jones","year":"1988","journal-title":"J. Neurophysiol."},{"key":"10.1016\/j.brainres.2016.12.030_b0130","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1586\/14737175.6.3.397","article-title":"Refractory epilepsy: mechanisms and solutions","volume":"6","author":"Kwan","year":"2006","journal-title":"Expert Rev. Neurother."},{"key":"10.1016\/j.brainres.2016.12.030_b0135","doi-asserted-by":"crossref","first-page":"4891","DOI":"10.1113\/jphysiol.2008.156281","article-title":"Epileptiform activities in slices of hippocampus from mice after intra-hippocampal injection of kainic acid","volume":"586","author":"Le Duigou","year":"2008","journal-title":"J. Physiol."},{"key":"10.1016\/j.brainres.2016.12.030_b0140","first-page":"301","article-title":"The dentate gyrus as a control point for seizures in the hippocampus and beyond","volume":"7","author":"Lothman","year":"1992","journal-title":"Epilepsy Res. Suppl."},{"key":"10.1016\/j.brainres.2016.12.030_b0145","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1212\/WNL.52.3.453","article-title":"Hippocampal GABA and glutamate transporter immunoreactivity in patients with temporal lobe epilepsy","volume":"52","author":"Mathern","year":"1999","journal-title":"Neurology"},{"key":"10.1016\/j.brainres.2016.12.030_b0150","series-title":"Encyclopedia of Basic Epilepsy Research","first-page":"569","article-title":"Using intrinsic optical signal changes to analyze epileptic activity and seizures","author":"Meierkord","year":"2009"},{"key":"10.1016\/j.brainres.2016.12.030_b0155","doi-asserted-by":"crossref","first-page":"25660","DOI":"10.1038\/srep25660","article-title":"Removing entorhinal cortex input to the dentate gyrus does not impede low frequency oscillations, an EEG-biomarker of hippocampal epileptogenesis","volume":"6","author":"Meyer","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.brainres.2016.12.030_b0160","doi-asserted-by":"crossref","first-page":"869","DOI":"10.1152\/jn.1987.57.3.869","article-title":"Low extracellular magnesium induces epileptiform activity and spreading depression in rat hippocampal slices","volume":"57","author":"Mody","year":"1987","journal-title":"J. Neurophysiol."},{"key":"10.1016\/j.brainres.2016.12.030_b0165","doi-asserted-by":"crossref","first-page":"14012","DOI":"10.1523\/JNEUROSCI.4390-07.2007","article-title":"Disrupted dentate granule cell chloride regulation enhances synaptic excitability during development of temporal lobe epilepsy","volume":"27","author":"Pathak","year":"2007","journal-title":"J. Neurosci."},{"key":"10.1016\/j.brainres.2016.12.030_b0170","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/0013-4694(72)90177-0","article-title":"Modification of seizure activity by electrical stimulation. II. Motor seizure","volume":"32","author":"Racine","year":"1972","journal-title":"Electroencephalogr. Clin. Neurophysiol."},{"key":"10.1016\/j.brainres.2016.12.030_b0175","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1016\/0306-4522(90)90324-W","article-title":"Responses of cells of the rat fascia dentata to prolonged stimulation of the perforant path: sensitivity of hilar cells and changes in granule cell excitability","volume":"35","author":"Scharfman","year":"1990","journal-title":"Neuroscience"},{"key":"10.1016\/j.brainres.2016.12.030_b0180","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1159\/000360925","article-title":"Anatomy of the hippocampal formation","volume":"34","author":"Schultz","year":"2014","journal-title":"Front. Neurol. Neurosci."},{"key":"10.1016\/j.brainres.2016.12.030_b0185","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/0006-8993(94)91594-6","article-title":"Chronic epileptogenicity following focal status epilepticus","volume":"655","author":"Shirasaka","year":"1994","journal-title":"Brain Res."},{"key":"10.1016\/j.brainres.2016.12.030_b0190","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1002\/hipo.450010106","article-title":"Permanently altered hippocampal structure, excitability, and inhibition after experimental status epilepticus in the rat: the \u201cdormant basket cell\u201d hypothesis and its possible relevance to temporal lobe epilepsy","volume":"1","author":"Sloviter","year":"1991","journal-title":"Hippocampus"},{"key":"10.1016\/j.brainres.2016.12.030_b0195","doi-asserted-by":"crossref","first-page":"640","DOI":"10.1002\/ana.410350604","article-title":"The functional organization of the hippocampal dentate gyrus and its relevance to the pathogenesis of temporal lobe epilepsy","volume":"35","author":"Sloviter","year":"1994","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.brainres.2016.12.030_b0200","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1002\/(SICI)1096-9861(19960930)373:4<593::AID-CNE8>3.0.CO;2-X","article-title":"Basal expression and induction of glutamate decarboxylase and GABA in excitatory granule cells of the rat and monkey hippocampal dentate gyrus","volume":"373","author":"Sloviter","year":"1996","journal-title":"J. Comp. Neurol."},{"key":"10.1016\/j.brainres.2016.12.030_b0205","doi-asserted-by":"crossref","unstructured":"Sloviter, R.S., Bumanglag, A.V., Schwarcz, R., Frotscher, M., 2012. Abnormal dentate gyrus network circuitry in temporal lobe epilepsy.","DOI":"10.1093\/med\/9780199746545.003.0034"},{"key":"10.1016\/j.brainres.2016.12.030_b0210","doi-asserted-by":"crossref","first-page":"508","DOI":"10.1152\/jn.1992.67.3.508","article-title":"Perforated patch-clamp analysis of the passive membrane properties of three classes of hippocampal neurons","volume":"67","author":"Spruston","year":"1992","journal-title":"J. Neurophysiol."},{"key":"10.1016\/j.brainres.2016.12.030_b0215","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/0920-1211(87)90051-9","article-title":"Epileptiform activity induced by lowering extracellular [Mg2+] in combined hippocampal-entorhinal cortex slices: modulation by receptors for norepinephrine and N-methyl-D-aspartate","volume":"1","author":"Stanton","year":"1987","journal-title":"Epilepsy Res."},{"key":"10.1016\/j.brainres.2016.12.030_b0220","doi-asserted-by":"crossref","first-page":"1016","DOI":"10.1523\/JNEUROSCI.05-04-01016.1985","article-title":"Evidence of functional mossy fiber sprouting in hippocampal formation of kainic acid-treated rats","volume":"5","author":"Tauck","year":"1985","journal-title":"J. Neurosci."},{"key":"10.1016\/j.brainres.2016.12.030_b0225","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1111\/j.1528-1157.1999.tb00718.x","article-title":"Halothane as a neuroprotectant during constant stimulation of the perforant path","volume":"40","author":"Walker","year":"1999","journal-title":"Epilepsia"},{"key":"10.1016\/j.brainres.2016.12.030_b0230","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1016\/0304-3940(86)90595-1","article-title":"Epileptiform activity in combined slices of the hippocampus, subiculum and entorhinal cortex during perfusion with low magnesium medium","volume":"69","author":"Walther","year":"1986","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.brainres.2016.12.030_b0235","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1006\/nbdi.2000.0298","article-title":"Optical imaging reveals characteristic seizure onsets, spread patterns, and propagation velocities in hippocampal-entorhinal cortex slices of juvenile rats","volume":"7","author":"Weissinger","year":"2000","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.brainres.2016.12.030_b0240","doi-asserted-by":"crossref","first-page":"853","DOI":"10.1523\/JNEUROSCI.1619-03.2004","article-title":"Translamellar disinhibition in the rat hippocampal dentate gyrus after seizure-induced degeneration of vulnerable hilar neurons","volume":"24","author":"Zappone","year":"2004","journal-title":"J. Neurosci."}],"container-title":["Brain Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006899316308514?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006899316308514?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,9,17]],"date-time":"2019-09-17T01:47:00Z","timestamp":1568684820000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006899316308514"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,3]]},"references-count":48,"alternative-id":["S0006899316308514"],"URL":"https:\/\/doi.org\/10.1016\/j.brainres.2016.12.030","relation":{},"ISSN":["0006-8993"],"issn-type":[{"value":"0006-8993","type":"print"}],"subject":[],"published":{"date-parts":[[2017,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Dentate gyrus autonomous ictal activity in the status epilepticus rat model of epilepsy","name":"articletitle","label":"Article Title"},{"value":"Brain Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.brainres.2016.12.030","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}