{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T10:33:48Z","timestamp":1788518028244,"version":"build-2803163510"},"reference-count":66,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2017,2,1]],"date-time":"2017-02-01T00:00:00Z","timestamp":1485907200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2017,2,1]],"date-time":"2017-02-01T00:00:00Z","timestamp":1485907200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2018,1,11]],"date-time":"2018-01-11T00:00:00Z","timestamp":1515628800000},"content-version":"am","delay-in-days":344,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100000006","name":"Office of Naval Research","doi-asserted-by":"publisher","award":["N00014-15-1-2072"],"award-info":[{"award-number":["N00014-15-1-2072"]}],"id":[{"id":"10.13039\/100000006","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Russian Federation","award":["15-04-05970"],"award-info":[{"award-number":["15-04-05970"]}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Brain Research"],"published-print":{"date-parts":[[2017,2]]},"DOI":"10.1016\/j.brainres.2016.12.032","type":"journal-article","created":{"date-parts":[[2017,1,4]],"date-time":"2017-01-04T11:47:14Z","timestamp":1483530434000},"page":"347-354","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":21,"special_numbering":"C","title":["Antiepileptic drugs prevent seizures in hyperbaric oxygen: A novel model of epileptiform activity"],"prefix":"10.1016","volume":"1657","author":[{"given":"Ivan T.","family":"Demchenko","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sergei Yu","family":"Zhilyaev","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander N.","family":"Moskvin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander I.","family":"Krivchenko","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claude A.","family":"Piantadosi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barry W.","family":"Allen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.brainres.2016.12.032_b0005","doi-asserted-by":"crossref","first-page":"638","DOI":"10.1111\/j.1528-1157.1996.tb00627.x","article-title":"Vigabatrin as initial therapy for infantile spasms: a European retrospective survey","volume":"37","author":"Aicardi","year":"1996","journal-title":"Epilepsia"},{"key":"10.1016\/j.brainres.2016.12.032_b0010","first-page":"106","article-title":"Two faces of nitric oxide: implications for cellular mechanisms of oxygen toxicity","author":"Allen","year":"2009","journal-title":"J. Appl. Physiol."},{"key":"10.1016\/j.brainres.2016.12.032_b0015","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1023\/A:1022393604014","article-title":"Novel mechanisms of action of three antiepileptic drugs, vigabatrin, tiagabine, and topiramate","volume":"28","author":"\u00c4ngehagen","year":"2003","journal-title":"Neurochem. Res."},{"key":"10.1016\/j.brainres.2016.12.032_b0020","series-title":"Pathology of Oxygen Toxicity","author":"Balentine","year":"1982"},{"key":"10.1016\/j.brainres.2016.12.032_b0025","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1152\/ajplegacy.1934.110.3.565","article-title":"The effect of oxygen on man at pressures from 1 to 4 atmospheres","volume":"110","author":"Behnke","year":"1935","journal-title":"Am. J. Physiol."},{"key":"10.1016\/j.brainres.2016.12.032_b0030","doi-asserted-by":"crossref","first-page":"866","DOI":"10.1016\/j.yebeh.2004.08.021","article-title":"Correlation analysis between anticonvulsant ED50 values of antiepileptic drugs in mice and rats and their therapeutic doses and plasma levels","volume":"5","author":"Bialer","year":"2004","journal-title":"Epilepsy Behav."},{"key":"10.1016\/j.brainres.2016.12.032_b0035","doi-asserted-by":"crossref","first-page":"1737","DOI":"10.1212\/01.wnl.0000187118.19221.e4","article-title":"Double-blind, placebo-controlled study of lamotrigine in primary generalized tonic-clonic seizures","volume":"65","author":"Biton","year":"2005","journal-title":"Neurology"},{"key":"10.1016\/j.brainres.2016.12.032_b0040","first-page":"169","article-title":"The effect of flumazenil on Cns oxygen-toxicity in the rat","volume":"17","author":"Bitterman","year":"1995","journal-title":"Methods Find. Exp. Clin. Pharmacol."},{"key":"10.1016\/j.brainres.2016.12.032_b0045","first-page":"843","article-title":"Mass versus molar doses, similarities and differences","volume":"63","author":"Chmielewska","year":"2008","journal-title":"Pharmazie"},{"key":"10.1016\/j.brainres.2016.12.032_b0050","series-title":"In Bennett and Elliott's Physiology and Medicine of Diving","first-page":"358","article-title":"Oxygen under pressure","author":"Clark","year":"2003"},{"key":"10.1016\/j.brainres.2016.12.032_b0055","doi-asserted-by":"crossref","first-page":"910","DOI":"10.1016\/j.clinph.2006.11.016","article-title":"Lamotrigine decreases EEG synchronization in a use-dependent manner in patients with idiopathic generalized epilepsy","volume":"118","author":"Clemens","year":"2007","journal-title":"Clin. Neurophysiol."},{"key":"10.1016\/j.brainres.2016.12.032_b0060","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/0006-8993(82)90740-5","article-title":"An electrophysiological analysis of oxygen and pressure on synaptic transmission","volume":"251","author":"Colton","year":"1982","journal-title":"Brain Res."},{"key":"10.1016\/j.brainres.2016.12.032_b0065","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/0006-8993(86)90995-9","article-title":"The action of oxygen and oxygen at high-pressure on inhibitory transmission","volume":"364","author":"Colton","year":"1986","journal-title":"Brain Res."},{"key":"10.1016\/j.brainres.2016.12.032_b0070","doi-asserted-by":"crossref","first-page":"C233","DOI":"10.1152\/ajpcell.1978.235.5.C233","article-title":"Effect of oxygen at high-pressure on spontaneous transmitter release","volume":"235","author":"Colton","year":"1978","journal-title":"Am. J. Physiol."},{"key":"10.1016\/j.brainres.2016.12.032_b0075","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1042\/bst0320529","article-title":"The Cys-loop superfamily of ligand-gated ion channels: the impact of receptor structure on function","volume":"32","author":"Connolly","year":"2004","journal-title":"Biochem. Soc. Trans."},{"key":"10.1016\/j.brainres.2016.12.032_b0080","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/S0387-7604(03)00090-1","article-title":"Lamotrigine as first-line drug in childhood absence epilepsy: a clinical and neurophysiological study","volume":"26","author":"Coppola","year":"2004","journal-title":"Brain Dev."},{"key":"10.1016\/j.brainres.2016.12.032_b0085","doi-asserted-by":"crossref","first-page":"3","DOI":"10.2174\/1568026053386962","article-title":"Mechanisms of action of antiepileptic drugs","volume":"5","author":"Czapinski","year":"2005","journal-title":"Curr. Top. Med. Chem."},{"key":"10.1016\/j.brainres.2016.12.032_b0090","doi-asserted-by":"crossref","first-page":"1030","DOI":"10.1152\/jn.01003.2006","article-title":"Superoxide (O2\u2212) production in CA1 neurons of rat hippocampal slices exposed to graded levels of oxygen","volume":"98","author":"D'Agostino","year":"2007","journal-title":"J. Neurophysiol."},{"key":"10.1016\/j.brainres.2016.12.032_b0095","doi-asserted-by":"crossref","first-page":"883","DOI":"10.1152\/japplphysiol.00920.2002","article-title":"Neuronal sensitivity to hyperoxia, hypercapnia, and inert gases at hyperbaric pressures","volume":"95","author":"Dean","year":"2003","journal-title":"J. Appl. Physiol."},{"key":"10.1016\/j.brainres.2016.12.032_b0100","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/S0006-8993(01)03057-8","article-title":"Nitric oxide production is enhanced in rat brain before oxygen-induced convulsions","volume":"917","author":"Demchenko","year":"2001","journal-title":"Brain Res."},{"key":"10.1016\/j.brainres.2016.12.032_b0105","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/S0304-3940(03)00432-4","article-title":"Oxygen seizure latency and peroxynitrite formation in mice lacking neuronal or endothelial nitric oxide synthases","volume":"344","author":"Demchenko","year":"2003","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.brainres.2016.12.032_b0110","doi-asserted-by":"crossref","first-page":"1288","DOI":"10.1038\/sj.jcbfm.9600110","article-title":"Cerebral blood flow and brain oxygenation in rats breathing oxygen under pressure","volume":"25","author":"Demchenko","year":"2005","journal-title":"J. Cereb. Blood Flow Metab."},{"key":"10.1016\/j.brainres.2016.12.032_b0115","first-page":"169","article-title":"Nitric oxide amplifies the imbalance of excitatory to inhibitory neurotransmission accelerating oxygen seizures","volume":"33","author":"Demchenko","year":"2006","journal-title":"Undersea Hyperb. Med."},{"key":"10.1016\/j.brainres.2016.12.032_b0120","first-page":"2006","article-title":"Similar but not the same: normobaric and hyperbaric pulmonary oxygen toxicity\u2013the role of nitric oxide","volume":"00450","author":"Demchenko","year":"2007","journal-title":"AJP Lung"},{"key":"10.1016\/j.brainres.2016.12.032_b0125","doi-asserted-by":"crossref","first-page":"1814","DOI":"10.1152\/japplphysiol.00902.2011","article-title":"Nitric oxide-mediated central sympathetic excitation promotes CNS and pulmonary O2 toxicity","volume":"112","author":"Demchenko","year":"2012","journal-title":"J. Appl. Physiol."},{"key":"10.1016\/j.brainres.2016.12.032_b0130","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1136\/bmj.1.4506.667","article-title":"Oxygen poisoning in man: Part I","volume":"1","author":"Donald","year":"1947","journal-title":"Br. Med. J."},{"key":"10.1016\/j.brainres.2016.12.032_b0135","doi-asserted-by":"crossref","first-page":"712","DOI":"10.1136\/bmj.1.4507.712","article-title":"Oxygen poisoning in man: Part II","volume":"1","author":"Donald","year":"1947","journal-title":"Br. Med. J."},{"key":"10.1016\/j.brainres.2016.12.032_b0140","first-page":"41","article-title":"Mechanisms of action of antiepileptic drugs","volume":"8","author":"Fariello","year":"1993","journal-title":"Epileptogenic Excitotoxic Mech."},{"key":"10.1016\/j.brainres.2016.12.032_b0145","unstructured":"Garcia, A.J., et al., 2003. Oxidative stress induced by hyperbaric oxygen increases the synaptic response of CA1 neurons in the rat hippocampus. In: FASEB Science Research Conference. Vol. 17, San Diego, CA., pp. A71."},{"key":"10.1016\/j.brainres.2016.12.032_b0150","first-page":"392","article-title":"Overview of drugs used for epilepsy and seizures: etiology, diagnosis, and treatment","volume":"35","author":"Goldenberg","year":"2010","journal-title":"Pharm. Ther."},{"key":"10.1016\/j.brainres.2016.12.032_b0155","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1038\/nn.3934","article-title":"Animal models in epilepsy research: legacies and new directions","volume":"18","author":"Grone","year":"2015","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.brainres.2016.12.032_b0160","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1152\/japplphysiol.00221.2013","article-title":"Vigabatrin prevents seizure in swine subjected to hyperbaric hyperoxia","volume":"115","author":"Hall","year":"2013","journal-title":"J. Appl. Physiol."},{"key":"10.1016\/j.brainres.2016.12.032_b0165","first-page":"877","article-title":"Influence of a Gaba transaminase inhibitor on central nervous-system oxygentoxicity","volume":"49","author":"Harel","year":"1978","journal-title":"Aviat. Space Environ. Med."},{"key":"10.1016\/j.brainres.2016.12.032_b0170","doi-asserted-by":"crossref","first-page":"638","DOI":"10.1016\/j.seizure.2010.10.026","article-title":"Advances in understanding basic mechanisms of epilepsy and seizures","volume":"19","author":"Jefferys","year":"2010","journal-title":"Seizure"},{"key":"10.1016\/j.brainres.2016.12.032_b0175","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1684\/j.1950-6945.2004.tb00075.x","article-title":"Efficacy and tolerability of zonisamide in juvenile myoclonic epilepsy","volume":"6","author":"Kothare","year":"2004","journal-title":"Epileptic Disord."},{"key":"10.1016\/j.brainres.2016.12.032_b0180","doi-asserted-by":"crossref","first-page":"2447","DOI":"10.1038\/srep02447","article-title":"The large conductance, calcium-activated K+ (BK) channel is regulated by cysteine string protein","volume":"3","author":"Kyle","year":"2013","journal-title":"Sci. Rep."},{"key":"10.1016\/j.brainres.2016.12.032_b0185","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1016\/S1734-1140(13)71060-0","article-title":"Research advances in basic mechanisms of seizures and antiepileptic drug action","volume":"65","author":"Laso\u0144","year":"2013","journal-title":"Pharmacol. Rep."},{"key":"10.1016\/j.brainres.2016.12.032_b0190","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/S1734-1140(11)70497-2","article-title":"Basic mechanisms of antiepileptic drugs and their pharmacokinetic\/pharmacodynamic interactions: an update","volume":"63","author":"Laso\u0144","year":"2011","journal-title":"Pharmacol. Rep."},{"key":"10.1016\/j.brainres.2016.12.032_b0195","doi-asserted-by":"crossref","first-page":"888","DOI":"10.1111\/j.1528-1167.2007.01526.x","article-title":"Lamotrigine inhibits postsynaptic AMPA receptor and glutamate release in the dentate gyrus","volume":"49","author":"Lee","year":"2008","journal-title":"Epilepsia"},{"key":"10.1016\/j.brainres.2016.12.032_b0200","doi-asserted-by":"crossref","first-page":"S5","DOI":"10.1016\/j.seizure.2004.04.016","article-title":"Zonisamide: chemistry, mechanism of action, and pharmacokinetics","volume":"13","author":"Leppik","year":"2004","journal-title":"Seizure-Eur. J. Epilepsy"},{"key":"10.1016\/j.brainres.2016.12.032_b0205","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/S0022-3565(25)03549-9","article-title":"A simplified method of evaluating dose-effect experiments","volume":"96","author":"Litchfield","year":"1949","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.brainres.2016.12.032_b0210","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1016\/j.seizure.2011.01.003","article-title":"Critical review of current animal models of seizures and epilepsy used in the discovery and development of new antiepileptic drugs","volume":"20","author":"Loscher","year":"2011","journal-title":"Seizure-Eur. J. Epilepsy"},{"key":"10.1016\/j.brainres.2016.12.032_b9000","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/0920-1211(94)90012-4","article-title":"Strategies in antiepileptic drug development - is rational drug design superior to random screening and structural variation","volume":"17","author":"Loscher","year":"1994","journal-title":"Epilepsy Res."},{"key":"10.1016\/j.brainres.2016.12.032_b0220","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/j.redox.2013.12.011","article-title":"Redox regulation of mitochondrial function with emphasis on cysteine oxidation reactions","volume":"2","author":"Mailloux","year":"2014","journal-title":"Redox Biol."},{"key":"10.1016\/j.brainres.2016.12.032_b0225","doi-asserted-by":"crossref","first-page":"328","DOI":"10.2174\/157015912804499447","article-title":"The role of reactive species in epileptogenesis and influence of antiepileptic drug therapy on oxidative stress","volume":"10","author":"Martinc","year":"2012","journal-title":"Curr. Neuropharmacol."},{"key":"10.1016\/j.brainres.2016.12.032_b0230","doi-asserted-by":"crossref","first-page":"L1184","DOI":"10.1152\/ajplung.00281.2003","article-title":"Regulation of ion channel structure and function by reactive oxygen-nitrogen species","volume":"285","author":"Matalon","year":"2003","journal-title":"Am. J. Physiol. \u2013 Lung Cell. Mol. Physiol."},{"key":"10.1016\/j.brainres.2016.12.032_b0235","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1111\/apha.12116","article-title":"Neurobiological insight into hyperbaric hyperoxia","volume":"209","author":"Micarelli","year":"2013","journal-title":"Acta Physiol."},{"key":"10.1016\/j.brainres.2016.12.032_b0240","doi-asserted-by":"crossref","first-page":"922","DOI":"10.1152\/japplphysiol.00865.2002","article-title":"Pressure (\u2a7d4 ATA) increases membrane conductance and firing rate in the rat solitary complex","volume":"95","author":"Mulkey","year":"2003","journal-title":"J. Appl. Physiol."},{"key":"10.1016\/j.brainres.2016.12.032_b0245","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1016\/S0306-4522(00)00114-7","article-title":"Redox modulation of recombinant human GABAA receptors","volume":"98","author":"Pan","year":"2000","journal-title":"Neuroscience"},{"key":"10.1016\/j.brainres.2016.12.032_b0250","doi-asserted-by":"crossref","first-page":"1951","DOI":"10.1016\/j.freeradbiomed.2004.08.021","article-title":"Mitochondrial dysfunction and oxidative stress: cause and consequence of epileptic seizures","volume":"37","author":"Patel","year":"2004","journal-title":"Free Radical Biol. Med."},{"key":"10.1016\/j.brainres.2016.12.032_b0255","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1111\/j.1476-5381.1967.tb01967.x","article-title":"Experiments on the convulsant and anaesthetic effects of oxygen","volume":"29","author":"Paton","year":"1967","journal-title":"Br. J. Pharmacol. Chemother."},{"key":"10.1016\/j.brainres.2016.12.032_b0260","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1016\/j.nbd.2015.07.005","article-title":"Reactive oxygen species mediate cognitive deficits in experimental temporal lobe epilepsy","volume":"82","author":"Pearson","year":"2015","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.brainres.2016.12.032_b0265","article-title":"Modification of seizure activity by electrical stimulation. 2 motor seizure","volume":"32","author":"Racine","year":"1972","journal-title":"Electroencephalography Clin. Neurophysiol."},{"key":"10.1016\/j.brainres.2016.12.032_b0270","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/B978-0-12-394596-9.00003-2","article-title":"Experimental models of seizures and epilepsies","volume":"105","author":"Raol","year":"2012","journal-title":"Anim. Models Mol. Pathol."},{"key":"10.1016\/j.brainres.2016.12.032_b0275","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1016\/0920-1211(87)90003-9","article-title":"Comparison of oxcarbazepine and carbamazepine: a double-blind study","volume":"1","author":"Reinikainen","year":"1987","journal-title":"Epilepsy Res."},{"key":"10.1016\/j.brainres.2016.12.032_b0280","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/0920-1211(91)90079-U","article-title":"The effect of carbamazepine and ethosuximide on hyperoxic seizures","volume":"8","author":"Reshef","year":"1991","journal-title":"Epilepsy Res."},{"key":"10.1016\/j.brainres.2016.12.032_b0285","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.eplepsyres.2005.09.012","article-title":"Molecular targets versus models for new antiepileptic drug discovery","volume":"68","author":"Rogawski","year":"2006","journal-title":"Epilepsy Res."},{"key":"10.1016\/j.brainres.2016.12.032_b0290","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1684\/j.1950-6945.2001.tb00392.x","article-title":"Update on the mechanisms of action of antiepileptic drugs","volume":"3","author":"Sills","year":"2001","journal-title":"Epileptic Disord."},{"key":"10.1016\/j.brainres.2016.12.032_b0295","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1016\/S0920-1211(98)00060-6","article-title":"Valproate selectively reduces the persistent fraction of Na+ current in neocortical neurons","volume":"32","author":"Taverna","year":"1998","journal-title":"Epilepsy Res."},{"key":"10.1016\/j.brainres.2016.12.032_b0300","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/0920-1211(96)00016-2","article-title":"Vigabatrin and behaviour disorders: a retrospective survey","volume":"25","author":"Thomas","year":"1996","journal-title":"Epilepsy Res."},{"key":"10.1016\/j.brainres.2016.12.032_b0305","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/0014-2999(91)90291-W","article-title":"The effect of vigabatrin on central-nervous-system oxygen-toxicity in rats","volume":"202","author":"Tzuk-Shina","year":"1991","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.brainres.2016.12.032_b0310","doi-asserted-by":"crossref","first-page":"1512","DOI":"10.1111\/j.1528-1157.1999.tb02034.x","article-title":"Modulation of sodium currents in rat CA1 neurons by carbamazepine and valproate after kindling epileptogenesis","volume":"40","author":"Vreugdenhil","year":"1999","journal-title":"Epilepsia"},{"key":"10.1016\/j.brainres.2016.12.032_b0315","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1007\/s10863-010-9320-9","article-title":"Mitochondrial dysfunction and oxidative stress: a contributing link to acquired epilepsy?","volume":"42","author":"Waldbaum","year":"2010","journal-title":"J. Bioenerg. Biomembr."},{"key":"10.1016\/j.brainres.2016.12.032_b0320","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1038\/1252","article-title":"Febrile seizures and generalized epilepsy associated with a mutation in the Na+-channel \u03b21 subunit gene SCN1B","volume":"19","author":"Wallace","year":"1998","journal-title":"Nat. Genet."},{"key":"10.1016\/j.brainres.2016.12.032_b9005","doi-asserted-by":"crossref","first-page":"4344","DOI":"10.2174\/092986711797200408","article-title":"Evaluation of anticonvulsants for possible use in neuropathic pain","volume":"18","author":"Waszkielewicz","year":"2011","journal-title":"Curr. Med. Chem."},{"key":"10.1016\/j.brainres.2016.12.032_b0325","doi-asserted-by":"crossref","first-page":"956","DOI":"10.1016\/S1474-4422(15)00148-9","article-title":"Mitochondrial dysfunction and seizures: the neuronal energy crisis","volume":"14","author":"Zsurka","year":"2015","journal-title":"Lancet Neurol."}],"container-title":["Brain Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006899316308617?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006899316308617?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,13]],"date-time":"2025-09-13T18:00:39Z","timestamp":1757786439000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006899316308617"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,2]]},"references-count":66,"alternative-id":["S0006899316308617"],"URL":"https:\/\/doi.org\/10.1016\/j.brainres.2016.12.032","relation":{},"ISSN":["0006-8993"],"issn-type":[{"value":"0006-8993","type":"print"}],"subject":[],"published":{"date-parts":[[2017,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Antiepileptic drugs prevent seizures in hyperbaric oxygen: A novel model of epileptiform activity","name":"articletitle","label":"Article Title"},{"value":"Brain Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.brainres.2016.12.032","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}