{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,16]],"date-time":"2026-03-16T20:53:30Z","timestamp":1773694410494,"version":"3.50.1"},"reference-count":66,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2017,6,1]],"date-time":"2017-06-01T00:00:00Z","timestamp":1496275200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"name":"DRA"},{"DOI":"10.13039\/501100001734","name":"University of Copenhagen","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001734","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Brain Research"],"published-print":{"date-parts":[[2017,6]]},"DOI":"10.1016\/j.brainres.2017.04.003","type":"journal-article","created":{"date-parts":[[2017,4,9]],"date-time":"2017-04-09T15:15:18Z","timestamp":1491750918000},"page":"74-79","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":8,"special_numbering":"C","title":["Anandamide and 2-AG are endogenously present within the laterodorsal tegmental nucleus: Functional implications for a role of eCBs in arousal"],"prefix":"10.1016","volume":"1665","author":[{"given":"Neeraj","family":"Soni","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bala Krishna","family":"Prabhala","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ved","family":"Mehta","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Osman","family":"Mirza","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kristi Anne","family":"Kohlmeier","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.brainres.2017.04.003_b0005","doi-asserted-by":"crossref","first-page":"2203","DOI":"10.1113\/jphysiol.2011.220855","article-title":"Endocannabinoids at the synapse a decade after the dies mirabilis (29 March 2001): what we still do not know","volume":"590","author":"Alger","year":"2012","journal-title":"J. Physiol."},{"key":"10.1016\/j.brainres.2017.04.003_b0010","doi-asserted-by":"crossref","first-page":"9953","DOI":"10.1523\/JNEUROSCI.2134-04.2004","article-title":"Circuitry for associative plasticity in the amygdala involves endocannabinoid signaling","volume":"24","author":"Azad","year":"2004","journal-title":"J. Neurosci."},{"key":"10.1016\/j.brainres.2017.04.003_b0015","doi-asserted-by":"crossref","first-page":"4708","DOI":"10.1523\/JNEUROSCI.2617-13.2014","article-title":"Discharge profiles across the sleep-waking cycle of identified cholinergic, GABAergic, and glutamatergic neurons in the pontomesencephalic tegmentum of the rat","volume":"34","author":"Boucetta","year":"2014","journal-title":"J. Neurosci."},{"key":"10.1016\/j.brainres.2017.04.003_b0020","doi-asserted-by":"crossref","first-page":"3242","DOI":"10.1098\/rstb.2011.0386","article-title":"Functional diversity on synaptic plasticity mediated by endocannabinoids","volume":"367","author":"Cachope","year":"2012","journal-title":"Philos. Trans. R. Soc. Lond. B Biol. Sci."},{"key":"10.1016\/j.brainres.2017.04.003_b0025","doi-asserted-by":"crossref","first-page":"1226","DOI":"10.1523\/JNEUROSCI.17-04-01226.1997","article-title":"Occurrence and biosynthesis of endogenous cannabinoid precursor, N-arachidonoyl phosphatidylethanolamine, in rat brain","volume":"17","author":"Cadas","year":"1997","journal-title":"J. Neurosci."},{"key":"10.1016\/j.brainres.2017.04.003_b0030","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/j.neuron.2012.09.020","article-title":"Endocannabinoid signaling and synaptic function","volume":"76","author":"Castillo","year":"2012","journal-title":"Neuron"},{"key":"10.1016\/j.brainres.2017.04.003_b0035","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1007\/BF02245075","article-title":"Acute and residual effects of alcohol and marijuana, alone and in combination, on mood and performance","volume":"115","author":"Chait","year":"1994","journal-title":"Psychopharmacology"},{"key":"10.1016\/j.brainres.2017.04.003_b0040","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1365\/s10337-008-0841-x","article-title":"Simultaneous quantification of anandamide and other endocannabinoids in dorsal vagal complex of rat brainstem by LC-MS","volume":"69","author":"Chen","year":"2009","journal-title":"Chromatographia"},{"key":"10.1016\/j.brainres.2017.04.003_b0045","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1146\/annurev.neuro.29.051605.112834","article-title":"Endocannabinoid-mediated synaptic plasticity in the CNS","volume":"29","author":"Chevaleyre","year":"2006","journal-title":"Annu. Rev. Neurosci."},{"key":"10.1016\/j.brainres.2017.04.003_b0050","doi-asserted-by":"crossref","first-page":"6698","DOI":"10.1073\/pnas.91.14.6698","article-title":"Enzymatic synthesis of anandamide, an endogenous ligand for the cannabinoid receptor, by brain membranes","volume":"91","author":"Devane","year":"1994","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.brainres.2017.04.003_b0055","doi-asserted-by":"crossref","first-page":"686","DOI":"10.1038\/372686a0","article-title":"Formation and inactivation of endogenous cannabinoid anandamide in central neurons","volume":"372","author":"Di Marzo","year":"1994","journal-title":"Nature"},{"key":"10.1016\/j.brainres.2017.04.003_b0060","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1007\/BF00248908","article-title":"Unitary characteristics of presumptive cholinergic tegmental neurons during the sleep-waking cycle in freely moving cats","volume":"76","author":"el Mansari","year":"1989","journal-title":"Exp. Brain Res."},{"key":"10.1016\/j.brainres.2017.04.003_b0065","doi-asserted-by":"crossref","first-page":"7656","DOI":"10.1073\/pnas.90.16.7656","article-title":"Anandamide, an endogenous cannabimimetic eicosanoid, binds to the cloned human cannabinoid receptor and stimulates receptor-mediated signal transduction","volume":"90","author":"Felder","year":"1993","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.brainres.2017.04.003_b0070","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/S0898-6568(98)00060-6","article-title":"Morphine and anandamide stimulate intracellular calcium transients in human arterial endothelial cells: coupling to nitric oxide release","volume":"11","author":"Fimiani","year":"1999","journal-title":"Cell. Signal."},{"key":"10.1016\/j.brainres.2017.04.003_b0075","doi-asserted-by":"crossref","first-page":"1017","DOI":"10.1152\/physrev.00004.2003","article-title":"Role of endogenous cannabinoids in synaptic signaling","volume":"83","author":"Freund","year":"2003","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.brainres.2017.04.003_b0080","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1016\/0014-2999(93)90468-W","article-title":"Pharmacological activity of the cannabinoid receptor agonist, anandamide, a brain constituent","volume":"231","author":"Fride","year":"1993","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.brainres.2017.04.003_b0085","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1016\/j.jchromb.2014.11.001","article-title":"A quantitiative LC-MS\/MS method for the measurement of arachidonic acid, prostanoids, endocannabinoids, N-acylethanolamines and steroids in human plasma","volume":"976\u2013977","author":"Gachet","year":"2015","journal-title":"J. Chromatogr. B Anal. Technol. Biomed. Life Sci."},{"key":"10.1016\/j.brainres.2017.04.003_b0090","doi-asserted-by":"crossref","first-page":"1646","DOI":"10.1021\/ja01062a046","article-title":"Isolation, structure, and partial synthesis of an active constituent of hashish","volume":"86","author":"Gaoni","year":"1964","journal-title":"J. Am. Chem. Soc."},{"key":"10.1016\/j.brainres.2017.04.003_b0095","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1146\/annurev.ph.57.030195.003343","article-title":"Nitric oxide signaling in the central nervous system","volume":"57","author":"Garthwaite","year":"1995","journal-title":"Annu. Rev. Physiol."},{"key":"10.1016\/j.brainres.2017.04.003_b0100","doi-asserted-by":"crossref","first-page":"R1","DOI":"10.1016\/S0014-2999(97)89683-5","article-title":"Inhibition of hippocampal acetylcholine release by cannabinoids: reversal by SR 141716A","volume":"327","author":"Gessa","year":"1997","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.brainres.2017.04.003_b0105","doi-asserted-by":"crossref","first-page":"1431","DOI":"10.1016\/S0022-3565(25)13092-9","article-title":"Electrically-evoked acetylcholine release from hippocampal slices is inhibited by the cannabinoid receptor agonist, WIN 55212\u20132, and is potentiated by the cannabinoid antagonist, SR-141716A","volume":"277","author":"Gifford","year":"1996","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.brainres.2017.04.003_b0110","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.jpba.2015.03.017","article-title":"Simultaneous determination of endocannabinoids in murine plasma and brain substructures by surrogate-based LC-MS\/MS: application in tumor-bearing mice","volume":"111","author":"Gong","year":"2015","journal-title":"J. Pharm. Biomed. Anal."},{"key":"10.1016\/j.brainres.2017.04.003_b0115","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1016\/j.ab.2012.09.031","article-title":"Quantitative LC-MS\/MS analysis of arachidonoyl amino acids in mouse brain with treatment of FAAH inhibitor","volume":"432","author":"Han","year":"2013","journal-title":"Anal. Biochem."},{"key":"10.1016\/j.brainres.2017.04.003_b0120","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1146\/annurev-biochem-060409-092612","article-title":"Applications of mass spectrometry to lipids and membranes","volume":"80","author":"Harkewicz","year":"2011","journal-title":"Annu. Rev. Biochem."},{"key":"10.1016\/j.brainres.2017.04.003_b0125","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/S0091-3057(96)00456-X","article-title":"Comparative effects of alcohol and marijuana on mood, memory, and performance","volume":"58","author":"Heishman","year":"1997","journal-title":"Pharmacol. Biochem. Behav."},{"key":"10.1016\/j.brainres.2017.04.003_b0130","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1124\/pr.54.2.161","article-title":"International Union of Pharmacology. XXVII. Classification of cannabinoid receptors 1","volume":"54","author":"Howlett","year":"2002","journal-title":"Pharmacol. Rev."},{"key":"10.1016\/j.brainres.2017.04.003_b0135","doi-asserted-by":"crossref","first-page":"s438","DOI":"10.2741\/1074","article-title":"Arousal systems","volume":"8","author":"Jones","year":"2003","journal-title":"Front. Biosci."},{"key":"10.1016\/j.brainres.2017.04.003_b0140","doi-asserted-by":"crossref","first-page":"592","DOI":"10.1038\/nn.2517","article-title":"Reduction in endocannabinoid tone is a homeostatic mechanism for specific inhibitory synapses","volume":"13","author":"Kim","year":"2010","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.brainres.2017.04.003_b0145","doi-asserted-by":"crossref","first-page":"495","DOI":"10.3233\/JAD-2008-15315","article-title":"Targeting the endocannabinoid system in Alzheimer's disease","volume":"15","author":"Koppel","year":"2008","journal-title":"J. Alzheimers Dis."},{"key":"10.1016\/j.brainres.2017.04.003_b0150","doi-asserted-by":"crossref","first-page":"10039","DOI":"10.1523\/JNEUROSCI.4112-14.2015","article-title":"Multiple forms of endocannabinoid and endovanilloid signaling regulate the tonic control of GABA release","volume":"35","author":"Lee","year":"2015","journal-title":"J. Neurosci."},{"key":"10.1016\/j.brainres.2017.04.003_b0155","doi-asserted-by":"crossref","first-page":"2431","DOI":"10.1002\/cbdv.200890208","article-title":"Mass-spectrometric identification of anandamide and 2-arachidonoylglycerol in nematodes","volume":"5","author":"Lehtonen","year":"2008","journal-title":"Chem. Biodivers."},{"key":"10.1016\/j.brainres.2017.04.003_b0160","doi-asserted-by":"crossref","first-page":"2159","DOI":"10.1152\/jn.2001.86.5.2159","article-title":"Activity-dependent nitric oxide concentration dynamics in the laterodorsal tegmental nucleus in vitro","volume":"86","author":"Leonard","year":"2001","journal-title":"J. Neurophysiol."},{"key":"10.1016\/j.brainres.2017.04.003_b0165","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1016\/j.jpha.2013.11.004","article-title":"Quantification of anandamide, oleoylethanolamide and palmitoylethanolamide in rodent brain tissue using high performance liquid chromatography-electrospray mass spectroscopy","volume":"4","author":"Liput","year":"2014","journal-title":"J. Pharm. Anal."},{"issue":"Suppl 1","key":"10.1016\/j.brainres.2017.04.003_b0170","doi-asserted-by":"crossref","first-page":"S19","DOI":"10.1038\/sj.ijo.0803273","article-title":"Mechanisms of CB1 receptor signaling: endocannabinoid modulation of synaptic strength","volume":"30","author":"Mackie","year":"2006","journal-title":"Int. J. Obes. (Lond)"},{"issue":"3","key":"10.1016\/j.brainres.2017.04.003_b0175","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1016\/0306-4522(92)90409-U","article-title":"Distribution of neuronal cannabinoid receptor in the adult rat brain: a comparative receptor binding radioautography and in situ hybridization histochemistry","volume":"48","author":"Mailleux","year":"1992","journal-title":"Neuroscience"},{"key":"10.1016\/j.brainres.2017.04.003_b0180","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1016\/0304-3940(92)90265-9","article-title":"Distribution of cannabinoid receptor messenger RNA in the human brain: an in situ hybridization histochemistry with oligonucleotides","volume":"143","author":"Mailleux","year":"1992","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.brainres.2017.04.003_b0185","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1016\/S0024-3205(99)00281-7","article-title":"Discovery and characterization of endogenous cannabinoids","volume":"65","author":"Martin","year":"1999","journal-title":"Life Sci."},{"issue":"4","key":"10.1016\/j.brainres.2017.04.003_b0190","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1002\/cne.903270406","article-title":"Localization of cannabinoid receptor mRNA in rat brain","volume":"327","author":"Matsuda","year":"1993","journal-title":"J. Comp. Neurol."},{"key":"10.1016\/j.brainres.2017.04.003_b0195","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/0006-2952(95)00109-D","article-title":"Identification of an endogenous 2-monoglyceride, present in canine gut, that binds to cannabinoid receptors","volume":"50","author":"Mechoulam","year":"1995","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.brainres.2017.04.003_b0200","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1017\/S1461145798001126","article-title":"Comment on 'Health aspects of cannabis: revisited' (Hollister)","volume":"1","author":"Mechoulam","year":"1998","journal-title":"Int. J. Neuropsychopharmacol."},{"key":"10.1016\/j.brainres.2017.04.003_b0205","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1176\/jnp.7.2.251","article-title":"Brain stem reticular formation and activation of the EEG. 1949 [classical article]","volume":"7","author":"Moruzzi","year":"1995","journal-title":"J. Neuropsych. Clin. Neurosci."},{"key":"10.1016\/j.brainres.2017.04.003_b0210","doi-asserted-by":"crossref","first-page":"6323","DOI":"10.1073\/pnas.1017689108","article-title":"Hyperactivation of anandamide synthesis and regulation of cell-cycle progression via cannabinoid type 1 (CB1) receptors in the regenerating liver","volume":"108","author":"Mukhopadhyay","year":"2011","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.brainres.2017.04.003_b0215","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1038\/365061a0","article-title":"Molecular characterization of a peripheral receptor for cannabinoids","volume":"365","author":"Munro","year":"1993","journal-title":"Nature"},{"key":"10.1016\/j.brainres.2017.04.003_b0220","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1016\/S0006-8993(98)00969-X","article-title":"Anandamide modulates sleep and memory in rats","volume":"812","author":"Murillo-Rodriguez","year":"1998","journal-title":"Brain Res."},{"issue":"Suppl","key":"10.1016\/j.brainres.2017.04.003_b0225","doi-asserted-by":"crossref","first-page":"S317","DOI":"10.1194\/jlr.R800051-JLR200","article-title":"Imaging of lipid species by MALDI mass spectrometry","volume":"50","author":"Murphy","year":"2009","journal-title":"J. Lipid Res."},{"key":"10.1016\/j.brainres.2017.04.003_b0230","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.conb.2014.03.017","article-title":"Endocannabinoid-mediated retrograde modulation of synaptic transmission","volume":"29","author":"Ohno-Shosaku","year":"2014","journal-title":"Curr. Opin. Neurobiol."},{"key":"10.1016\/j.brainres.2017.04.003_b0235","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1111\/j.1530-0277.1988.tb00193.x","article-title":"Interaction between marihuana and ethanol: effects on psychomotor performance","volume":"12","author":"Perez-Reyes","year":"1988","journal-title":"Alcohol. Clin. Exp. Res."},{"key":"10.1016\/j.brainres.2017.04.003_b0240","doi-asserted-by":"crossref","first-page":"726","DOI":"10.1016\/S0166-2236(00)02002-6","article-title":"The sleep switch: hypothalamic control of sleep and wakefulness","volume":"24","author":"Saper","year":"2001","journal-title":"Trends Neurosci."},{"key":"10.1016\/j.brainres.2017.04.003_b0245","doi-asserted-by":"crossref","first-page":"664","DOI":"10.1038\/sj.bjp.0704297","article-title":"Despite substantial degradation, 2-arachidonoylglycerol is a potent full efficacy agonist mediating CB(1) receptor-dependent G-protein activation in rat cerebellar membranes","volume":"134","author":"Savinainen","year":"2001","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.brainres.2017.04.003_b0250","doi-asserted-by":"crossref","first-page":"3635","DOI":"10.1111\/ejn.12730","article-title":"Neurophysiological evidence for the presence of cannabinoid CB1 receptors in the laterodorsal tegmental nucleus","volume":"40","author":"Soni","year":"2014","journal-title":"Eur. J. Neurosci."},{"issue":"3","key":"10.1016\/j.brainres.2017.04.003_b0255","doi-asserted-by":"crossref","first-page":"1255","DOI":"10.1007\/s00429-014-0969-4","article-title":"Endocannabinoid CB1 receptor-mediated rises in Ca and depolarization-induced suppression of inhibition within the laterodorsal tegmental nucleus","volume":"221","author":"Soni","year":"2016","journal-title":"Brain Struct. Funct."},{"key":"10.1016\/j.brainres.2017.04.003_b0260","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1038\/42015","article-title":"A second endogenous cannabinoid that modulates long-term potentiation","volume":"388","author":"Stella","year":"1997","journal-title":"Nature"},{"key":"10.1016\/j.brainres.2017.04.003_b0265","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1152\/jn.1982.48.2.352","article-title":"Neocortical and caudate projections of intralaminar thalamic neurons and their synaptic excitation from midbrain reticular core","volume":"48","author":"Steriade","year":"1982","journal-title":"J. Neurophysiol."},{"key":"10.1016\/j.brainres.2017.04.003_b0270","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1126\/science.8235588","article-title":"Thalamocortical oscillations in the sleeping and aroused brain","volume":"262","author":"Steriade","year":"1993","journal-title":"Science"},{"key":"10.1016\/j.brainres.2017.04.003_b0275","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1126\/science.272.5259.225","article-title":"Arousal: revisiting the reticular activating system","volume":"272","author":"Steriade","year":"1996","journal-title":"Science"},{"key":"10.1016\/j.brainres.2017.04.003_b0280","doi-asserted-by":"crossref","first-page":"890","DOI":"10.1093\/oxfordjournals.jbchem.a021838","article-title":"Is the cannabinoid CB1 receptor a 2-arachidonoylglycerol receptor? Structural requirements for triggering a Ca2+ transient in NG108-15 cells","volume":"122","author":"Sugiura","year":"1997","journal-title":"J. Biochem."},{"key":"10.1016\/j.brainres.2017.04.003_b0285","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1016\/j.plipres.2006.03.003","article-title":"Biochemistry, pharmacology and physiology of 2-arachidonoylglycerol, an endogenous cannabinoid receptor ligand","volume":"45","author":"Sugiura","year":"2006","journal-title":"Prog. Lipid Res."},{"key":"10.1016\/j.brainres.2017.04.003_b0290","doi-asserted-by":"crossref","first-page":"5490","DOI":"10.1523\/JNEUROSCI.18-14-05490.1998","article-title":"Behavioral state control through differential serotonergic inhibition in the mesopontine cholinergic nuclei: a simultaneous unit recording and microdialysis study","volume":"18","author":"Thakkar","year":"1998","journal-title":"J. Neurosci."},{"key":"10.1016\/j.brainres.2017.04.003_b0295","doi-asserted-by":"crossref","first-page":"530","DOI":"10.1111\/j.1476-5381.2010.00790.x","article-title":"Endocannabinoid signalling: has it got rhythm?","volume":"160","author":"Vaughn","year":"2010","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.brainres.2017.04.003_b0300","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/0304-3940(83)90124-6","article-title":"NADPH-diaphorase: a selective histochemical marker for the cholinergic neurons of the pontine reticular formation","volume":"43","author":"Vincent","year":"1983","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.brainres.2017.04.003_b0305","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1016\/0306-4522(92)90184-4","article-title":"Histochemical mapping of nitric oxide synthase in the rat brain","volume":"46","author":"Vincent","year":"1992","journal-title":"Neuroscience"},{"key":"10.1016\/j.brainres.2017.04.003_b0310","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1038\/sj.bjp.0705667","article-title":"Cannabinoids and neuroinflammation","volume":"141","author":"Walter","year":"2004","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.brainres.2017.04.003_b0315","doi-asserted-by":"crossref","first-page":"5236","DOI":"10.1523\/JNEUROSCI.14-09-05236.1994","article-title":"State-dependent release of acetylcholine in rat thalamus measured by in vivo microdialysis","volume":"14","author":"Williams","year":"1994","journal-title":"J. Neurosci."},{"key":"10.1016\/j.brainres.2017.04.003_b0320","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1523\/JNEUROSCI.17-01-00420.1997","article-title":"Nitric oxide production in rat thalamus changes with behavioral state, local depolarization, and brainstem stimulation","volume":"17","author":"Williams","year":"1997","journal-title":"J. Neurosci."},{"key":"10.1016\/j.brainres.2017.04.003_b0325","doi-asserted-by":"crossref","first-page":"e63262","DOI":"10.1371\/journal.pone.0063262","article-title":"The second intracellular loop of the human cannabinoid CB2 receptor governs G protein coupling in coordination with the carboxyl terminal domain","volume":"8","author":"Zheng","year":"2013","journal-title":"PLoS ONE"},{"key":"10.1016\/j.brainres.2017.04.003_b0330","doi-asserted-by":"crossref","first-page":"706","DOI":"10.1016\/j.bbalip.2011.08.004","article-title":"Quantification of endocannabinoids in biological systems by chromatography and mass spectrometry: A comprehensive review from an analytical and biological perspective","volume":"1811","author":"Zoerner","year":"2011","journal-title":"Biochimica et Biophysica Acta (BBA)"}],"container-title":["Brain Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006899317301579?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006899317301579?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,6,17]],"date-time":"2025-06-17T21:34:39Z","timestamp":1750196079000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006899317301579"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,6]]},"references-count":66,"alternative-id":["S0006899317301579"],"URL":"https:\/\/doi.org\/10.1016\/j.brainres.2017.04.003","relation":{},"ISSN":["0006-8993"],"issn-type":[{"value":"0006-8993","type":"print"}],"subject":[],"published":{"date-parts":[[2017,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Anandamide and 2-AG are endogenously present within the laterodorsal tegmental nucleus: Functional implications for a role of eCBs in arousal","name":"articletitle","label":"Article Title"},{"value":"Brain Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.brainres.2017.04.003","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}