{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T01:54:44Z","timestamp":1791338084378,"version":"4.3.1"},"reference-count":170,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2017,9,1]],"date-time":"2017-09-01T00:00:00Z","timestamp":1504224000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2017,9,1]],"date-time":"2017-09-01T00:00:00Z","timestamp":1504224000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2017,9,1]],"date-time":"2017-09-01T00:00:00Z","timestamp":1504224000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2017,9,1]],"date-time":"2017-09-01T00:00:00Z","timestamp":1504224000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2017,9,1]],"date-time":"2017-09-01T00:00:00Z","timestamp":1504224000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2017,9,1]],"date-time":"2017-09-01T00:00:00Z","timestamp":1504224000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2017,9,1]],"date-time":"2017-09-01T00:00:00Z","timestamp":1504224000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100003056","name":"Ente Cassa di Risparmio di Firenze","doi-asserted-by":"publisher","award":["2015.0904A2202.3934"],"award-info":[{"award-number":["2015.0904A2202.3934"]}],"id":[{"id":"10.13039\/501100003056","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Brain Research"],"published-print":{"date-parts":[[2017,9]]},"DOI":"10.1016\/j.brainres.2017.06.023","type":"journal-article","created":{"date-parts":[[2017,6,23]],"date-time":"2017-06-23T19:45:56Z","timestamp":1498247156000},"page":"173-184","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":133,"special_numbering":"C","title":["The fate of the brain cholinergic neurons in neurodegenerative diseases"],"prefix":"10.1016","volume":"1670","author":[{"given":"Giancarlo","family":"Pepeu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Grazia Giovannini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.brainres.2017.06.023_b0005","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1016\/0741-8329(92)90070-Q","article-title":"The effect of long-term alcohol intake on brain NGF-target cells of aged rats","volume":"9","author":"Aloe","year":"1992","journal-title":"Alcohol"},{"key":"10.1016\/j.brainres.2017.06.023_b0010","doi-asserted-by":"crossref","DOI":"10.1016\/0376-8716(93)90068-2","article-title":"The effect of chronic ethanol intake on brain NGF level and on NGF-target tissues of adult mice","volume":"31","author":"Aloe","year":"1993","journal-title":"Drug Alcohol Depend."},{"key":"10.1016\/j.brainres.2017.06.023_b0015","doi-asserted-by":"crossref","DOI":"10.1196\/annals.1404.024","article-title":"ProNGF, sortilin, and age-related neurodegeneration Ann","volume":"1119","author":"Al-Shawi","year":"2007","journal-title":"N. Y. Acad. Sci."},{"key":"10.1016\/j.brainres.2017.06.023_b0020","series-title":"Aging of the Brain and Dementia","first-page":"151","article-title":"A discrete sampling technique in senile dementia of the Alzheimer type and alcoholic dementia: Study of the cholinergic system","author":"Antuono","year":"1980"},{"key":"10.1016\/j.brainres.2017.06.023_b0025","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1136\/jnnp.38.7.669","article-title":"Regional distribution of choline acetyltransferase in the human brain: changes in Huntington's chorea","volume":"38","author":"Aquilonius","year":"1975","journal-title":"J. Neurol. Neurosurg. Psychiatry."},{"key":"10.1016\/j.brainres.2017.06.023_b0030","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1007\/s11920-003-0074-5","article-title":"The cholinergic hypothesis of cognitive impairment caused by traumatic brain injury","volume":"5","author":"Arciniegas","year":"2003","journal-title":"Curr. Psychiatry Rep."},{"key":"10.1016\/j.brainres.2017.06.023_b0035","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1007\/BF00697388","article-title":"Loss of neurons in the nucleus basalis of Meynert in Alzheimer's disease, paralysis agitans and Korsakoff's Disease","volume":"61","author":"Arendt","year":"1983","journal-title":"Acta Neuropathol."},{"key":"10.1016\/j.brainres.2017.06.023_b0040","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1016\/0361-9230(88)90193-1","article-title":"Loss of neurons in the rat basal forebrain cholinergic projection system after prolonged intake of ethanol","volume":"21","author":"Arendt","year":"1988","journal-title":"Brain Res. Bull."},{"key":"10.1016\/j.brainres.2017.06.023_b0045","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1016\/j.brainresbull.2016.08.018","article-title":"Tau and tauopathies","volume":"126","author":"Arendt","year":"2016","journal-title":"Brain Res. Bull."},{"key":"10.1016\/j.brainres.2017.06.023_b0050","doi-asserted-by":"crossref","first-page":"2153","DOI":"10.2147\/NDT.S72067","article-title":"Decreased serum level of NGF in alcohol-dependent patients with declined executive function","volume":"10","author":"Bae","year":"2014","journal-title":"Neuropsychiatr. Dis. Treat."},{"key":"10.1016\/j.brainres.2017.06.023_b0055","doi-asserted-by":"crossref","first-page":"1722","DOI":"10.1093\/brain\/awv024","article-title":"Neuronal amyloid-\u03b2 accumulation within cholinergic basal forebrain in ageing and Alzheimer's disease","volume":"138","author":"Baker-Nigh","year":"2015","journal-title":"Brain"},{"key":"10.1016\/j.brainres.2017.06.023_b0060","doi-asserted-by":"crossref","first-page":"1199","DOI":"10.1016\/j.neuron.2016.09.006","article-title":"Basal forebrain cholinergic circuits and signaling in cognition and cognitive decline","volume":"91","author":"Ballinger","year":"2016","journal-title":"Neuron"},{"key":"10.1016\/j.brainres.2017.06.023_b0065","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1126\/science.7046051","article-title":"The cholinergic hypothesis of geriatric memory dysfunction","volume":"217","author":"Bartus","year":"1982","journal-title":"Science"},{"key":"10.1016\/j.brainres.2017.06.023_b0070","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1016\/0022-510X(73)90175-5","article-title":"Brain dopamine and the syndromes of Parkinson and Huntington. Clinical, morphological and neurochemical correlations","volume":"20","author":"Bernheimer","year":"1973","journal-title":"J. Neurol. Sci."},{"key":"10.1016\/j.brainres.2017.06.023_b0075","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1016\/j.bbr.2009.12.048","article-title":"The cholinergic system and Parkinson disease","volume":"21","author":"Bohnen","year":"2011","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.brainres.2017.06.023_b0080","doi-asserted-by":"crossref","first-page":"1609","DOI":"10.1038\/jcbfm.2012.60","article-title":"Heterogeneity of cholinergic denervation in Parkinson's disease without dementia","volume":"32","author":"Bohnen","year":"2012","journal-title":"J. Cereb. Blood. Flow Metab."},{"key":"10.1016\/j.brainres.2017.06.023_b0085","first-page":"194","article-title":"Frequency of cholinergic and caudate nucleus dopaminergic deficits across the predemented cognitive spectrum of Parkinson disease and evidence of interaction effects. J.A.M.A","volume":"72","author":"Bohnen","year":"2015","journal-title":"Neurol."},{"key":"10.1016\/j.brainres.2017.06.023_b0090","doi-asserted-by":"crossref","first-page":"951","DOI":"10.1002\/gps.4373","article-title":"Dementia with Lewy bodies can be well-differentiated from Alzheimer's disease by measurement of brain acetylcholinesterase activity-[(11) C]MP4A PET study","volume":"31","author":"Bohnen","year":"2016","journal-title":"Int. J. Geriatr. Psychiatry."},{"key":"10.1016\/j.brainres.2017.06.023_b0095","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/S0304-3940(97)00210-3","article-title":"Choline acetyltransferase mRNA expression in the striatal neurons of patients with Alzheimer's disease","volume":"225","author":"Boissi\u00e8re","year":"1997","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.brainres.2017.06.023_b0100","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1159\/000106594","article-title":"Trk neurotrophin receptors in cholinergic neurons of patients with Alzheimer's disease","volume":"8","author":"Boissi\u00e8re","year":"1997","journal-title":"Dement Geriatr. Cogn. Disord."},{"key":"10.1016\/j.brainres.2017.06.023_b0105","doi-asserted-by":"crossref","first-page":"737","DOI":"10.3233\/JAD-131154","article-title":"Do cholinesterase inhibitors act primarily on attention deficit? A naturalistic study in Alzheimer's disease patients","volume":"40","author":"Bracco","year":"2014","journal-title":"J. Alzheimers Dis."},{"key":"10.1016\/j.brainres.2017.06.023_b0110","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1097\/NEN.0b013e3181aed9e6","article-title":"Amyloid beta-induced nerve growth factor dysmetabolism in Alzheimer disease","volume":"68","author":"Bruno","year":"2009","journal-title":"J. Neuropathol. Exp. Neurol."},{"key":"10.1016\/j.brainres.2017.06.023_b0115","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1016\/0306-4522(93)90346-H","article-title":"Long-term ethanol consumption by rats: effect on acetylcholine release in vivo, choline acetyltransferase activity, and behavior","volume":"56","author":"Casamenti","year":"1993","journal-title":"Neuroscience"},{"key":"10.1016\/j.brainres.2017.06.023_b0120","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1007\/BF02253437","article-title":"Effect of nerve growth factor and GM1 ganglioside on the recovery of cholinergic neurons after a lesion of the nucleus basalis in aging rats","volume":"7","author":"Casamenti","year":"1994","journal-title":"J. Neural. Transm. Park. Dis. Dement. Sect."},{"key":"10.1016\/j.brainres.2017.06.023_b0125","doi-asserted-by":"crossref","first-page":"1262","DOI":"10.1212\/WNL.33.10.1262","article-title":"The nucleus basalis in Huntington's disease","volume":"33","author":"Clark","year":"1983","journal-title":"Neurology"},{"key":"10.1016\/j.brainres.2017.06.023_b0130","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/B978-0-444-62619-6.00010-0","article-title":"Molecular and neurologic responses to chronic alcohol","volume":"125","author":"Costin","year":"2014","journal-title":"Handb. Clin. Neurol."},{"key":"10.1016\/j.brainres.2017.06.023_b0135","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1016\/j.it.2015.04.007","article-title":"The choreography of neuroinflammation in Huntington's disease","volume":"36","author":"Crotti","year":"2015","journal-title":"Trends Immunol."},{"key":"10.1016\/j.brainres.2017.06.023_b0140","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1007\/s12031-009-9238-z","article-title":"Cholinergic involvement in Alzheimer's disease. A link with NGF maturation and degradation","volume":"40","author":"Cuello","year":"2010","journal-title":"J. Mol. Neurosci."},{"key":"10.1016\/j.brainres.2017.06.023_b0145","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1111\/j.1365-2990.1995.tb01065.x","article-title":"Neurofibrillary tangles in chronic alcoholics","volume":"21","author":"Cullen","year":"1995","journal-title":"Neuropathol. Appl. Neurobiol."},{"key":"10.1016\/j.brainres.2017.06.023_b0150","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1007\/BF01991785","article-title":"Mechanisms of cell death in cholinergic basal forebrain neurons in chronic alcoholics","volume":"10","author":"Cullen","year":"1995","journal-title":"Metab. Brain Dis."},{"issue":"4509\u20134518","key":"10.1016\/j.brainres.2017.06.023_b0155","first-page":"2014","article-title":"A major external source of cholinergic innervation of the striatum and nucleus accumbens originates in the brainstem","volume":"34","author":"Dautan","year":"2014","journal-title":"J. Neurosci."},{"key":"10.1016\/j.brainres.2017.06.023_b0160","doi-asserted-by":"crossref","first-page":"1403","DOI":"10.1016\/S0140-6736(76)91936-X","article-title":"Selective loss of central cholinergic neurons in Alzheimer's disease","volume":"2","author":"Davies","year":"1976","journal-title":"Lancet"},{"key":"10.1016\/j.brainres.2017.06.023_b0165","doi-asserted-by":"crossref","first-page":"1293","DOI":"10.1056\/NEJMp1007051","article-title":"Traumatic brain injury\u2013football, warfare, and long-term effects","volume":"363","author":"DeKosky","year":"2010","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.brainres.2017.06.023_b0170","doi-asserted-by":"crossref","first-page":"3518","DOI":"10.1002\/cne.24013","article-title":"Cholinergic interneurons in the Q140 knockin mouse model of Huntington's disease: reductions in dendritic branching and thalamostriatal input","volume":"524","author":"Deng","year":"2016","journal-title":"J. Comp. Neurol."},{"key":"10.1016\/j.brainres.2017.06.023_b0175","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1111\/j.1750-3639.1998.tb00158.x","article-title":"Pick's disease: a modern approach","volume":"8","author":"Dickson","year":"1998","journal-title":"Brain Pathol."},{"key":"10.1016\/j.brainres.2017.06.023_b0180","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1111\/j.1365-2990.2011.01203.x","article-title":"Neuropathological analysis of brainstem cholinergic and catecholaminergic nuclei in relation to rapid eye movement (REM) sleep behaviour disorder","volume":"38","author":"Dugger","year":"2012","journal-title":"Neuropathol. Appl. Neurobiol."},{"key":"10.1016\/j.brainres.2017.06.023_b0185","doi-asserted-by":"crossref","first-page":"1331","DOI":"10.1136\/jnnp.2007.127878","article-title":"Amyloid load in Parkinson's disease dementia and Lewy body dementia measured with [11C]PIB positron emission tomography","volume":"79","author":"Edison","year":"2008","journal-title":"J. Neurol. Neurosurg. Psychiatry."},{"key":"10.1016\/j.brainres.2017.06.023_b0190","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1016\/S0197-4580(97)00038-9","article-title":"Vesicular acetylcholine transporter density and Alzheimer's disease","volume":"18","author":"Efange","year":"1987","journal-title":"Neurobiol. Aging."},{"key":"10.1016\/j.brainres.2017.06.023_b0195","doi-asserted-by":"crossref","first-page":"2319","DOI":"10.1007\/s00429-015-1045-4","article-title":"Pedunculopontine cell loss and protein aggregation direct microglia activation in parkinsonian rats","volume":"221","author":"Elson","year":"2016","journal-title":"Brain Struct. Funct."},{"key":"10.1016\/j.brainres.2017.06.023_b0200","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/j.expneurol.2011.08.010","article-title":"Reduced striatal acetylcholine efflux in the R6\/2 mouse model of Huntington's disease: an examination of the role of altered inhibitory and excitatory mechanisms","volume":"232","author":"Farrar","year":"2011","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.brainres.2017.06.023_b0205","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1016\/0006-8993(87)90694-9","article-title":"Sparing of acetylcholinesterase-containing striatal neurons in Huntington's disease","volume":"411","author":"Ferrante","year":"1987","journal-title":"Brain Res."},{"key":"10.1016\/j.brainres.2017.06.023_b0210","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1385\/JMN:20:3:349","article-title":"M1 muscarinic agonists can modulate some of the hallmarks in Alzheimer's disease: Implications in future therapy","volume":"20","author":"Fisher","year":"2003","journal-title":"J. Mol. Neurosci."},{"key":"10.1016\/j.brainres.2017.06.023_b0215","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1038\/329065a0","article-title":"Amelioration of cholinergic neuron atrophy and spatial memory impairment in aged rats by nerve growth factor","volume":"329","author":"Fischer","year":"1987","journal-title":"Nature"},{"key":"10.1016\/j.brainres.2017.06.023_b0220","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1002\/mds.26624","article-title":"Oligomeropathies and pathogenesis of Alzheimer and Parkinson's diseases","volume":"31","author":"Forloni","year":"2016","journal-title":"Mov. Disord."},{"key":"10.1016\/j.brainres.2017.06.023_b0225","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1007\/s00702-005-0361-x","article-title":"Chronic alcohol intoxication in rats leads to a strong but transient increase in NGF levels in distinct brain regions","volume":"113","author":"Gericke","year":"2006","journal-title":"J. Neural. Transm. (Vienna)"},{"key":"10.1016\/j.brainres.2017.06.023_b0230","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1016\/0306-4522(89)90399-0","article-title":"Cortical cholinergic fibers in aging and Alzheimer's disease: a morphometric study","volume":"33","author":"Geula","year":"1989","journal-title":"Neuroscience"},{"key":"10.1016\/j.brainres.2017.06.023_b0235","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1097\/00005072-199801000-00008","article-title":"Relationship between plaques, tangles and loss of cortical cholinergic fibers in Alzheimer disease","volume":"57","author":"Geula","year":"1998","journal-title":"J. Neuropathol. Exp. Neurol."},{"key":"10.1016\/j.brainres.2017.06.023_b0240","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1111\/j.1471-4159.2006.03764.x","article-title":"Down regulation of trk but not p75NTR gene expression in single cholinergic basal forebrain neurons mark the progression of Alzheimer's disease","volume":"97","author":"Ginsberg","year":"2006","journal-title":"J. Neurochem."},{"key":"10.1016\/j.brainres.2017.06.023_b0245","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1016\/0306-4522(94)00610-H","article-title":"Differential effects of amyloid peptides beta-(1\u201340) and beta-(25\u201335) injections into the rat nucleus basalis","volume":"66","author":"Giovannelli","year":"1995","journal-title":"Neuroscience"},{"key":"10.1016\/j.brainres.2017.06.023_b0250","first-page":"31","article-title":"Experimental brain inflammation and neurodegeneration as model of Alzheimer's disease: Protective effects of selective COX-2 inhibitors","volume":"16","author":"Giovannini","year":"2003","journal-title":"Int. J. Immunopathol. Pharmacol."},{"key":"10.1016\/j.brainres.2017.06.023_b0255","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1212\/CON.0000000000000309","article-title":"Lewy Body Dementias: Dementia with Lewy Bodies and Parkinson Disease Dementia","volume":"22","author":"Gomperts","year":"2016","journal-title":"Continuum (Minneap Minn)."},{"key":"10.1016\/j.brainres.2017.06.023_b0260","first-page":"159","article-title":"Chronic ethanol consumption and thiamine deficiency modulate \u03b2-amyloid peptide level and oxidative stress in the brain","volume":"52","author":"Gong","year":"2016","journal-title":"Alcohol Alcohol."},{"key":"10.1016\/j.brainres.2017.06.023_b0265","doi-asserted-by":"crossref","first-page":"1939","DOI":"10.1007\/s00415-014-7439-z","article-title":"Atrophy of the cholinergic basal forebrain in dementia with Lewy bodies and Alzheimer's disease dementia","volume":"261","author":"Grothe","year":"2014","journal-title":"J. Neurol."},{"key":"10.1016\/j.brainres.2017.06.023_b0270","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1002\/cne.902740403","article-title":"Ascending projections from the pedunculopontine tegmental nucleus and the adjacent mesopontine tegmentum in the rat","volume":"274","author":"Hallanger","year":"1988","journal-title":"J. Comp. Neurol."},{"key":"10.1016\/j.brainres.2017.06.023_b0275","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1126\/science.1566067","article-title":"Alzheimer\u2019s-disease - the amyloid cascade hypothesis","volume":"256","author":"Hardy","year":"1992","journal-title":"Science"},{"key":"10.1016\/j.brainres.2017.06.023_b0280","doi-asserted-by":"crossref","first-page":"1162","DOI":"10.1097\/NEN.0000000000000014","article-title":"Pedunculopontine cholinergic cell loss in hallucinating Parkinson disease patients but not in dementia with Lewy bodies patients","volume":"72","author":"Hepp","year":"2013","journal-title":"J. Neuropathol. Exp. Neurol."},{"key":"10.1016\/j.brainres.2017.06.023_b0285","doi-asserted-by":"crossref","first-page":"2058","DOI":"10.1093\/brain\/awq120","article-title":"Cholinergic imaging in corticobasal syndrome, progressive supranuclear palsy and frontotemporal dementia","volume":"133","author":"Hirano","year":"2010","journal-title":"Brain"},{"key":"10.1016\/j.brainres.2017.06.023_b0290","doi-asserted-by":"crossref","first-page":"5976","DOI":"10.1073\/pnas.84.16.5976","article-title":"Neuronal loss in the pedunculopontine tegmental nucleus in Parkinson disease and in progressive supranuclear palsy","volume":"84","author":"Hirsch","year":"1987","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"issue":"Suppl. 1","key":"10.1016\/j.brainres.2017.06.023_b0295","doi-asserted-by":"crossref","first-page":"S210","DOI":"10.1016\/S1353-8020(11)70065-7","article-title":"Neuroinflammation in Parkinson's disease","volume":"18","author":"Hirsch","year":"2012","journal-title":"Parkinsonism Relat. Disord."},{"key":"10.1016\/j.brainres.2017.06.023_b0300","doi-asserted-by":"crossref","DOI":"10.1523\/ENEURO.0008-14.2015","article-title":"Enhanced GABAergic inputs contribute to functional alterations of cholinergic interneurons in the R6\/2 mouse model of Huntington's Disease","volume":"2","author":"Holley","year":"2015","journal-title":"eNeuro"},{"key":"10.1016\/j.brainres.2017.06.023_b0305","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1016\/j.expneurol.2004.06.011","article-title":"Alzheimer's pathology in human temporal cortex surgically excised after severe brain injury","volume":"190","author":"Ikonomovic","year":"2004","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.brainres.2017.06.023_b0310","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1007\/s12017-013-8242-1","article-title":"Nicotine prevents synaptic impairment induced by amyloid-\u03b2 oligomers through \u03b17-nicotinic acetylcholine receptor activation","volume":"15","author":"Inestrosa","year":"2013","journal-title":"Neuromolecular Med."},{"key":"10.1016\/j.brainres.2017.06.023_b0315","doi-asserted-by":"crossref","first-page":"S29","DOI":"10.1016\/j.parkreldis.2015.09.020","article-title":"Tauopathies as clinicopathological entities","volume":"22","author":"Irwin","year":"2016","journal-title":"Parkinsonism Relat. Disord."},{"key":"10.1016\/j.brainres.2017.06.023_b0320","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1016\/j.tips.2014.04.010","article-title":"Nerve growth factor metabolic dysfunction in Alzheimer's disease and Down syndrome","volume":"35","author":"Iulita","year":"2014","journal-title":"Trends Pharmacol. Sci."},{"key":"10.1016\/j.brainres.2017.06.023_b0325","doi-asserted-by":"crossref","first-page":"53","DOI":"10.2174\/1567205012666150921100030","article-title":"The NGF metabolic pathway in the CNS and its dysregulation in Down syndrome and Alzheimer's disease","volume":"13","author":"Iulita","year":"2016","journal-title":"Curr. Alzheimer Res."},{"key":"10.1016\/j.brainres.2017.06.023_b0330","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1016\/0169-328X(94)90159-7","article-title":"NGF mRNA is not decreased in frontal cortex from Alzheimer's disease patients","volume":"25","author":"Jett\u00e9","year":"1994","journal-title":"Brain Res. Mol. Brain Res."},{"key":"10.1016\/j.brainres.2017.06.023_b0335","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1001\/archinte.1996.00440050031004","article-title":"Lewy body disease and dementia. A review","volume":"156","author":"Kalra","year":"1996","journal-title":"Arch. Intern. Med."},{"key":"10.1016\/j.brainres.2017.06.023_b0340","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1007\/s00401-002-0621-x","article-title":"Cholinergic neuronal loss in the basal forebrain and mesopontine tegmentum of progressive supranuclear palsy and corticobasal degeneration","volume":"105","author":"Kasashima","year":"2003","journal-title":"Acta Neuropathol."},{"key":"10.1016\/j.brainres.2017.06.023_b0345","doi-asserted-by":"crossref","first-page":"969","DOI":"10.1001\/archneur.61.6.969","article-title":"Frontotemporal dementia\/Pick's disease","volume":"61","author":"Kertesz","year":"2004","journal-title":"Arch. Neurol."},{"key":"10.1016\/j.brainres.2017.06.023_b0350","first-page":"1841","article-title":"Parallel Atrophy of Cortex and Basal Forebrain Cholinergic System in Mild Cognitive Impairment","volume":"27","author":"Kilimann","year":"2017","journal-title":"Cereb Cortex"},{"key":"10.1016\/j.brainres.2017.06.023_b0355","doi-asserted-by":"crossref","first-page":"10627","DOI":"10.1523\/JNEUROSCI.0620-09.2009","article-title":"The p75 neurotrophin receptor promotes amyloid beta (1\u201342)-induced neuritic dystrophy in vitro and in vivo","volume":"29","author":"Knowles","year":"2009","journal-title":"J. Neurosci."},{"key":"10.1016\/j.brainres.2017.06.023_b0360","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/j.brainres.2010.05.076","article-title":"Analysis of the cholinergic pathology in the P301L tau transgenic pR5 model of tauopathy","volume":"1347","author":"K\u00f6hler","year":"2010","journal-title":"Brain Res."},{"key":"10.1016\/j.brainres.2017.06.023_b0365","doi-asserted-by":"crossref","first-page":"1473","DOI":"10.1111\/acer.13102","article-title":"Beer drinking associates with lower burden of amyloid beta aggregation in the brain: Helsinki sudden death series","volume":"40","author":"Kok","year":"2016","journal-title":"Alcohol Clin. Exp. Res."},{"key":"10.1016\/j.brainres.2017.06.023_b0370","doi-asserted-by":"crossref","first-page":"981","DOI":"10.1089\/neu.2012.2699","article-title":"Neurochemical profile of dementia pugilistica","volume":"30","author":"Kokjohn","year":"2013","journal-title":"J. Neurotrauma"},{"key":"10.1016\/j.brainres.2017.06.023_b0375","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/j.neulet.2012.02.083","article-title":"Thalamic cholinergic innervation is spared in Alzheimer disease compared to parkinsonian disorders","volume":"514","author":"Kotagal","year":"2012","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.brainres.2017.06.023_b0380","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1126\/science.3798108","article-title":"Nerve growth factor treatment after brain injury prevents neuronal death","volume":"235","author":"Kromer","year":"1987","journal-title":"Science"},{"key":"10.1016\/j.brainres.2017.06.023_b0385","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1002\/ana.410400309","article-title":"In vivo mapping of cholinergic terminals in normal aging, Alzheimer's disease, and Parkinson's disease","volume":"40","author":"Kuhl","year":"1996","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.brainres.2017.06.023_b0390","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1038\/nrn3406","article-title":"The many faces of alpha-synuclein: from structure and toxicity to therapeutic target","volume":"14","author":"Lashuel","year":"2013","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.brainres.2017.06.023_b0395","doi-asserted-by":"crossref","first-page":"702","DOI":"10.1038\/nrneurol.2010.145","article-title":"Cell-to-cell transmission of non-prion protein aggregates","volume":"6","author":"Lee","year":"2012","journal-title":"Nat. Rev. Neurol."},{"key":"10.1016\/j.brainres.2017.06.023_b0400","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1016\/j.tig.2004.01.008","article-title":"Huntingtin-protein interactions and the pathogenesis of Huntington's disease","volume":"20","author":"Li","year":"2004","journal-title":"Trends Genet."},{"key":"10.1016\/j.brainres.2017.06.023_b0405","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1111\/bpa.12371","article-title":"Neuroinflammation in synucleinopathies","volume":"26","author":"Lim","year":"2016","journal-title":"Brain Pathol."},{"key":"10.1016\/j.brainres.2017.06.023_b0410","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1016\/j.biomaterials.2015.08.010","article-title":"Direct hippocampal injection of pseudo lentivirus-delivered nerve growth factor gene rescues the damaged cognitive function after traumatic brain injury in the rat","volume":"69","author":"Lin","year":"2015","journal-title":"Biomaterials"},{"key":"10.1016\/j.brainres.2017.06.023_b0415","doi-asserted-by":"crossref","first-page":"1115","DOI":"10.1126\/science.3992249","article-title":"Loss of M2 muscarine receptors in the cerebral cortex in Alzheimer's disease and experimental cholinergic denervation","volume":"228","author":"Mash","year":"1985","journal-title":"Science"},{"key":"10.1016\/j.brainres.2017.06.023_b0420","doi-asserted-by":"crossref","first-page":"12245","DOI":"10.1073\/pnas.211412398","article-title":"Beta-amyloid peptides enhance alpha-synuclein accumulation and neuronal deficits in a transgenic mouse model linking Alzheimer's disease and Parkinson's disease","volume":"98","author":"Masliah","year":"2001","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.brainres.2017.06.023_b0425","doi-asserted-by":"crossref","first-page":"912","DOI":"10.1212\/WNL.23.9.912","article-title":"Choline acetylase and glutamic acid decarboxylase in Huntington's chorea. A preliminary study","volume":"23","author":"McGeer","year":"1973","journal-title":"Neurology"},{"key":"10.1016\/j.brainres.2017.06.023_b0430","doi-asserted-by":"crossref","first-page":"853","DOI":"10.3233\/JAD-160488","article-title":"Inflammation, antiinflammatory agents, and Alzheimer's Disease: The last 22 years","volume":"54","author":"McGeer","year":"2016","journal-title":"J. Alzheimer\u2019s Dis."},{"key":"10.1016\/j.brainres.2017.06.023_b0435","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1016\/0306-4522(92)90292-A","article-title":"Molecular cloning of rat trkC and distribution of cells expressing messenger RNAs for members of the trk family in the rat central nervous system","volume":"51","author":"Merlio","year":"1992","journal-title":"Neuroscience"},{"key":"10.1016\/j.brainres.2017.06.023_b0440","doi-asserted-by":"crossref","first-page":"1343","DOI":"10.1016\/j.neurobiolaging.2012.10.024","article-title":"Cascade of tau toxicity in inducible hippocampal brain slices and prevention by aggregation inhibitors","volume":"34","author":"Messing","year":"2013","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.brainres.2017.06.023_b0445","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1101\/lm.69204","article-title":"The cholinergic lesion of Alzheimer\u2019s disease: pivotal factor or side show?","volume":"11","author":"Mesulam","year":"2004","journal-title":"Learn. Memory."},{"key":"10.1016\/j.brainres.2017.06.023_b0450","doi-asserted-by":"crossref","first-page":"4124","DOI":"10.1002\/cne.23415","article-title":"Cholinergic circuitry of the human nucleus basalis and its fate in Alzheimer\u2019s disease","volume":"521","author":"Mesulam","year":"2013","journal-title":"J. Comp. Neurol."},{"key":"10.1016\/j.brainres.2017.06.023_b0455","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1002\/cne.902140206","article-title":"Cholinergic innervations of cortex by the basal forebrain: cytochemistry and cortical connections of the septal area. Diagonal band nuclei, nucleus basalis (substantia innominata) and hypothalamus in the Rhesus monkey","volume":"214","author":"Mesulam","year":"1983","journal-title":"J. Comp. Neurol."},{"key":"10.1016\/j.brainres.2017.06.023_b0460","doi-asserted-by":"crossref","DOI":"10.1016\/0306-4522(83)90108-2","article-title":"Central cholinergic pathways in the rat: an overview based on an alternative nomenclature (Ch1-Ch6)","volume":"10","author":"Mesulam","year":"1983","journal-title":"Neuroscience"},{"key":"10.1016\/j.brainres.2017.06.023_b0465","doi-asserted-by":"crossref","first-page":"815","DOI":"10.1002\/ana.20100","article-title":"Cholinergic nucleus basalis tauopathy emerges early in the aging-MCI-AD continuum","volume":"55","author":"Mesulam","year":"2004","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.brainres.2017.06.023_b0470","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1002\/neu.20059","article-title":"Chronic exposure to ethanol alters neurotrophin content in the basal forebrain-cortex system in the mature rat: effects on autocrine-paracrine mechanisms","volume":"60","author":"Miller","year":"2004","journal-title":"J. Neurobiol."},{"key":"10.1016\/j.brainres.2017.06.023_b0475","series-title":"Neurobiology of Alzheimer\u2019s Disease","first-page":"245","article-title":"Alzheimer\u2019s disease as a neurotransmitter disease","author":"Mitchell","year":"2009"},{"key":"10.1016\/j.brainres.2017.06.023_b0480","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/j.brainres.2012.12.016","article-title":"Pattern of tau hyperphosphorylation and neurotransmitter markers in the brainstem of senescent tau filament forming transgenic mice","volume":"1497","author":"Morcinek","year":"2013","journal-title":"Brain Res."},{"key":"10.1016\/j.brainres.2017.06.023_b0485","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1016\/0006-8993(86)91114-5","article-title":"Cholinergic projections from the parabigeminal nucleus (Ch8) to the superior colliculus in the mouse: a combined analysis of Brain horseradish peroxidase transport and choline acetyltransferase immunohistochemistry","volume":"370","author":"Mufson","year":"1986","journal-title":"Brain Res."},{"key":"10.1016\/j.brainres.2017.06.023_b0490","doi-asserted-by":"crossref","first-page":"1143","DOI":"10.1001\/archneur.60.8.1143","article-title":"Preservation of brain nerve growth factor in mild cognitive impairment and Alzheimer disease","volume":"60","author":"Mufson","year":"2003","journal-title":"Arch. Neurol."},{"key":"10.1016\/j.brainres.2017.06.023_b0495","doi-asserted-by":"crossref","first-page":"340","DOI":"10.2174\/156720507781788855","article-title":"Cholinotrophic molecular substrates of mild cognitive impairment in the elderly","volume":"4","author":"Mufson","year":"2007","journal-title":"Curr. Alzheimer Res."},{"key":"10.1016\/j.brainres.2017.06.023_b0500","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1007\/s11910-013-0377-9","article-title":"Cholinergic dysfunction in Parkinson's disease","volume":"13","author":"M\u00fcller","year":"2013","journal-title":"Curr. Neurol. Neurosci. Rep."},{"key":"10.1016\/j.brainres.2017.06.023_b0505","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1002\/mds.26061","article-title":"Clinical markers for identifying cholinergic deficits in Parkinson's disease","volume":"30","author":"M\u00fcller","year":"2015","journal-title":"Mov. Disord."},{"key":"10.1016\/j.brainres.2017.06.023_b0510","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1089\/neu.1998.15.295","article-title":"Cortical cholinergic dysfunction after human head injury","volume":"15","author":"Murdoch","year":"1998","journal-title":"J. Neurotrauma"},{"key":"10.1016\/j.brainres.2017.06.023_b0515","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1089\/08977150252807018","article-title":"Nucleus basalis of Meynert pathology in the human brain after fatal head injury","volume":"19","author":"Murdoch","year":"2002","journal-title":"J. Neurotrauma"},{"key":"10.1016\/j.brainres.2017.06.023_b0520","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/0304-3940(83)90264-1","article-title":"Choline acetyltransferase immunohistochemistry in brains of Alzheimer's disease patients and controls","volume":"36","author":"Nagai","year":"1983","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.brainres.2017.06.023_b0525","doi-asserted-by":"crossref","DOI":"10.31887\/DCNS.2016.18.1\/pnopoulos","article-title":"Huntington disease: a single-gene degenerative disorder of the striatum","volume":"18","author":"Nopoulos","year":"2016","journal-title":"Dialogues Clin. Neurosci."},{"key":"10.1016\/j.brainres.2017.06.023_b0530","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.neuint.2008.06.005","article-title":"Interactions between the amyloid and cholinergic mechanisms in Alzheimer's disease","volume":"53","author":"Pakaski","year":"2008","journal-title":"Neurochem. Int."},{"key":"10.1016\/j.brainres.2017.06.023_b0535","doi-asserted-by":"crossref","first-page":"e2","DOI":"10.1017\/S1462399411002134","article-title":"Neuronal receptors as targets for the action of amyloid-beta protein (A\u03b2) in the brain","volume":"14","author":"Patel","year":"2012","journal-title":"Expert. Rev. Mol. Med."},{"key":"10.1016\/j.brainres.2017.06.023_b0540","doi-asserted-by":"crossref","first-page":"58","DOI":"10.3389\/fncel.2012.00058","article-title":"Understanding the neuroinflammatory response following concussion to develop treatment strategies","volume":"6","author":"Patterson","year":"2012","journal-title":"Front. Cell. Neurosci."},{"key":"10.1016\/j.brainres.2017.06.023_b0545","doi-asserted-by":"crossref","first-page":"907","DOI":"10.1084\/jem.20011797","article-title":"Role of p75 neurotrophin receptor in the neurotoxicity by beta-amyloid peptides and synergistic effect of inflammatory cytokines","volume":"195","author":"Perini","year":"2002","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.brainres.2017.06.023_b0550","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/S0140-6736(77)91780-9","article-title":"Necropsy evidence of central cholinergic deficits in senile dementia","volume":"1","author":"Perry","year":"1977","journal-title":"Lancet"},{"key":"10.1016\/j.brainres.2017.06.023_b0555","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1007\/978-3-7091-6846-2_8","article-title":"Lewy body dementia\u2013clinical, pathological and neurochemical interconnections","volume":"51","author":"Perry","year":"1997","journal-title":"J. Neural. Transm. Suppl."},{"key":"10.1016\/j.brainres.2017.06.023_b0560","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1016\/j.neuron.2012.08.036","article-title":"Acetylcholine as a neuromodulator: cholinergic signaling shapes nervous system function and behavior","volume":"76","author":"Picciotto","year":"2012","journal-title":"Neuron"},{"key":"10.1016\/j.brainres.2017.06.023_b0565","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1007\/s00429-013-0669-5","article-title":"An animal model mimicking pedunculopontine nucleus cholinergic degeneration in Parkinson's disease","volume":"220","author":"Pienaar","year":"2015","journal-title":"Brain Struct. Funct."},{"key":"10.1016\/j.brainres.2017.06.023_b0570","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1186\/s40478-015-0199-x","article-title":"Amyloid accelerates tau propagation and toxicity in a model of early Alzheimer's disease","volume":"3","author":"Pooler","year":"2015","journal-title":"Acta Neuropathol. Commun."},{"key":"10.1016\/j.brainres.2017.06.023_b0575","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1126\/science.aag2590","article-title":"How neuroinflammation contributes to neurodegeneration","volume":"353","author":"Ransohoff","year":"2016","journal-title":"Science"},{"key":"10.1016\/j.brainres.2017.06.023_b0580","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1016\/j.neuron.2010.12.038","article-title":"Habenula \u2018\u2018cholinergic\u201d neurons co-release glutamate and acetylcholine and activate postsynaptic neurons via distinct transmission modes","volume":"69","author":"Ren","year":"2011","journal-title":"Neuron"},{"key":"10.1016\/j.brainres.2017.06.023_b0585","doi-asserted-by":"crossref","first-page":"2312","DOI":"10.1523\/JNEUROSCI.06-08-02312.1986","article-title":"Distribution of neuronal receptors for nerve growth factor in the rat","volume":"6","author":"Richardson","year":"1986","journal-title":"J. Neurosci."},{"key":"10.1016\/j.brainres.2017.06.023_b0590","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1016\/0197-4580(89)90090-0","article-title":"The etiology of Alzheimer's disease: an epidemiologic point of view","volume":"10","author":"Rocca","year":"1989","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.brainres.2017.06.023_b0595","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/S0301-0082(02)00016-3","article-title":"Neurotrophin signaling through the p75 neurotrophin receptor","volume":"67","author":"Roux","year":"2002","journal-title":"Prog. Neurobiol."},{"key":"10.1016\/j.brainres.2017.06.023_b0600","doi-asserted-by":"crossref","first-page":"726","DOI":"10.1111\/bpa.12426","article-title":"Huntington's disease (HD): the neuropathology of a multisystem neurodegenerative disorder of the human brain","volume":"26","author":"R\u00fcb","year":"2016","journal-title":"Brain Pathol."},{"key":"10.1016\/j.brainres.2017.06.023_b0605","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1002\/ana.410180503","article-title":"Dopaminergic and cholinergic lesions in progressive supranuclear palsy","volume":"18","author":"Ruberg","year":"1985","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.brainres.2017.06.023_b0610","doi-asserted-by":"crossref","first-page":"2589","DOI":"10.1523\/JNEUROSCI.20-07-02589.2000","article-title":"Phenotypic knockout of nerve growth factor in adult transgenic mice reveals severe deficits in basal forebrain cholinergic neurons, cell death in the spleen and skeletal muscle dystrophy","volume":"20","author":"Ruberti","year":"2000","journal-title":"J. Neurosci."},{"key":"10.1016\/j.brainres.2017.06.023_b0615","doi-asserted-by":"crossref","first-page":"423","DOI":"10.2174\/156652406777435444","article-title":"Acetylcholine receptors and tau phosphorylation","volume":"6","author":"Rubio","year":"2006","journal-title":"Curr. Mol. Med."},{"key":"10.1016\/j.brainres.2017.06.023_b0620","doi-asserted-by":"crossref","first-page":"910","DOI":"10.1016\/j.neuron.2016.02.003","article-title":"The biology of Huntingtin","volume":"89","author":"Sadou","year":"2016","journal-title":"Neuron"},{"key":"10.1016\/j.brainres.2017.06.023_b0625","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1212\/01.wnl.0000298691.71637.96","article-title":"Mesopontine cholinergic neuron involvement in Lewy body dementia and multiple system atrophy","volume":"70","author":"Schmeichel","year":"2008","journal-title":"Neurology."},{"key":"10.1016\/j.brainres.2017.06.023_b0630","doi-asserted-by":"crossref","first-page":"496","DOI":"10.3171\/jns.1995.83.3.0496","article-title":"Loss of forebrain cholinergic neurons following fluid-percussion injury: implications for cognitive impairment in closed head injury","volume":"83","author":"Schmidt","year":"1995","journal-title":"J. Neurosurg."},{"key":"10.1016\/j.brainres.2017.06.023_b0635","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1016\/0306-4522(94)90491-X","article-title":"Human striatum: chemoarchitecture of the caudate nucleus, putamen and ventral striatum in health and Alzheimer's disease","volume":"60","author":"Selden","year":"1994","journal-title":"Neuroscience"},{"key":"10.1016\/j.brainres.2017.06.023_b0640","doi-asserted-by":"crossref","first-page":"595","DOI":"10.15252\/emmm.201606210","article-title":"The amyloid hypothesis of Alzheimer's disease at 25 years","volume":"8","author":"Selkoe","year":"2016","journal-title":"EMBO Mol. Med."},{"key":"10.1016\/j.brainres.2017.06.023_b0645","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1002\/mds.26369","article-title":"Striatal and cortical \u03b2-amyloidopathy and cognition in Parkinson's Disease","volume":"31","author":"Shah","year":"2016","journal-title":"Mov. Disord."},{"key":"10.1016\/j.brainres.2017.06.023_b0650","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1212\/WNL.0b013e3181ab2b58","article-title":"Mapping of brain acetylcholinesterase alterations in Lewy body disease by PET","volume":"73","author":"Shimada","year":"2009","journal-title":"Neurology."},{"key":"10.1016\/j.brainres.2017.06.023_b0655","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1002\/1531-8249(199907)46:1<62::AID-ANA10>3.0.CO;2-P","article-title":"Positron emission tomographic measurement of acetylcholinesterase activity reveals differential loss of ascending cholinergic systems in Parkinson's disease and progressive supranuclear palsy","volume":"46","author":"Shinotoh","year":"1999","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.brainres.2017.06.023_b0660","doi-asserted-by":"crossref","DOI":"10.1111\/j.1749-6632.2003.tb07097.x","article-title":"The amygdala and Alzheimer's disease: positron emission tomographic study of the cholinergic system","volume":"985","author":"Shinotoh","year":"2003","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"10.1016\/j.brainres.2017.06.023_b0665","doi-asserted-by":"crossref","first-page":"534","DOI":"10.1016\/j.neuron.2008.11.007","article-title":"Linking Abeta and tau in late-onset Alzheimer's disease: a dual pathway hypothesis","volume":"26","author":"Small","year":"2008","journal-title":"Neuron"},{"key":"10.1016\/j.brainres.2017.06.023_b0670","doi-asserted-by":"crossref","first-page":"3119","DOI":"10.1093\/hmg\/ddl252","article-title":"Cholinergic neuronal defect without cell loss in Huntington's disease","volume":"15","author":"Smith","year":"2006","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.brainres.2017.06.023_b0675","doi-asserted-by":"crossref","first-page":"7971","DOI":"10.1523\/JNEUROSCI.0775-16.2016","article-title":"Reducing endogenous \u03b1-synucleine mitigates the degeneration of selective neuronal populations in an Alzheimer's disease transgenic mouse model","volume":"36","author":"Spencer","year":"2016","journal-title":"J. Neurosci."},{"key":"10.1016\/j.brainres.2017.06.023_b0680","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/S1353-8020(99)00031-0","article-title":"Parkinson's disease, dementia with Lewy bodies and multiple system atrophy are alpha-synucleinopathies","volume":"5","author":"Spillantini","year":"1999","journal-title":"Parkinsonism Relat. Disord."},{"key":"10.1016\/j.brainres.2017.06.023_b0685","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1038\/42166","article-title":"Alpha-synuclein in Lewy bodies","volume":"388","author":"Spillantini","year":"1997","journal-title":"Nature"},{"key":"10.1016\/j.brainres.2017.06.023_b0690","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1093\/brain\/103.1.179","article-title":"Neurochemical alterations in Huntington's chorea: a study of post-mortem brain tissue","volume":"103","author":"Spokes","year":"1980","journal-title":"Brain."},{"key":"10.1016\/j.brainres.2017.06.023_b0695","first-page":"21","article-title":"Imaging of neuroinflammation in dementia: a review","volume":"87","author":"Stefaniak","year":"2016","journal-title":"J. Neurol. Neurosurg. Psychiatry"},{"key":"10.1016\/j.brainres.2017.06.023_b0700","doi-asserted-by":"crossref","first-page":"4766","DOI":"10.1523\/JNEUROSCI.12-12-04766.1992","article-title":"Does loss of nerve growth factor receptors precede loss of cholinergic neurons in Alzheimer's disease? An autoradiographic study in the human striatum and basal forebrain","volume":"12","author":"Strada","year":"1992","journal-title":"J. Neurosci."},{"key":"10.1016\/j.brainres.2017.06.023_b0705","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.expneurol.2008.05.016","article-title":"Neuroinflammation as a neurotoxic mechanism in alcoholism: commentary on \u201cIncreased MCP-1 and microglia in various regions of human alcoholic brain\u201d","volume":"213","author":"Sullivan","year":"2008","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.brainres.2017.06.023_b0710","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1016\/j.jns.2011.06.048","article-title":"Dopamine-depletion and increased alpha-synuclein load induce degeneration of cortical cholinergic fibers in mice","volume":"310","author":"Szego","year":"2011","journal-title":"J. Neurol. Sci."},{"key":"10.1016\/j.brainres.2017.06.023_b0715","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1016\/j.neurobiolaging.2012.04.012","article-title":"Impairment of the septal cholinergic neurons in MPTP-treated A30P \u03b1-synuclein mice","volume":"34","author":"Szego","year":"2013","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.brainres.2017.06.023_b0720","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1007\/BF00697397","article-title":"A neuronal loss in the basal nucleus of Meynert in progressive supranuclear palsy","volume":"61","author":"Tagliavini","year":"1983","journal-title":"Acta Neuropathol."},{"key":"10.1016\/j.brainres.2017.06.023_b0725","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/0304-3940(84)90217-9","article-title":"The basal nucleus of Meynert in patients with progressive supranuclear palsy","volume":"44","author":"Tagliavini","year":"1984","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.brainres.2017.06.023_b0730","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1212\/WNL.54.2.407","article-title":"Cholinergic dysfunction in diseases with Lewy bodies","volume":"54","author":"Tiraboschi","year":"2000","journal-title":"Neurology."},{"key":"10.1016\/j.brainres.2017.06.023_b0735","doi-asserted-by":"crossref","first-page":"946","DOI":"10.1001\/archpsyc.59.10.946","article-title":"Early and widespread cholinergic losses differentiate dementia with Lewy bodies from Alzheimer disease","volume":"59","author":"Tiraboschi","year":"2002","journal-title":"Arch. Gen. Psychiatry."},{"key":"10.1016\/j.brainres.2017.06.023_b0740","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1016\/j.biopsych.2015.08.013","article-title":"Alpha-synuclein produces early behavioral alterations via striatal cholinergic synaptic dysfunction by interacting with GluN2D N-methyl-D-aspartate receptor subunit","volume":"79","author":"Tozzi","year":"2016","journal-title":"Biol Psychiatry"},{"issue":"Suppl. 1","key":"10.1016\/j.brainres.2017.06.023_b0745","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1111\/jnc.13640","article-title":"Therapy and clinical trials in frontotemporal dementia: past, present, and future","volume":"138","author":"Tsai","year":"2016","journal-title":"J. Neurochem."},{"key":"10.1016\/j.brainres.2017.06.023_b0750","first-page":"1139","article-title":"Nerve growth factor gene therapy: activation of neuronal responses in Alzheimer disease","volume":"72","author":"Tuszynski","year":"2015","journal-title":"J.A.M.A. Neurol."},{"key":"10.1016\/j.brainres.2017.06.023_b0755","first-page":"99","article-title":"Dementia pugilistica: loss of brain cholinergic neurons and cholinergic cortical markers","volume":"12","author":"Uhl","year":"1982","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.brainres.2017.06.023_b0760","doi-asserted-by":"crossref","first-page":"2533","DOI":"10.1016\/j.ajpath.2011.07.044","article-title":"Progression of tau pathology in cholinergic basal forebrain neurons in mild cognitive impairment and Alzheimer's disease","volume":"179","author":"Vana","year":"2011","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.brainres.2017.06.023_b0765","doi-asserted-by":"crossref","first-page":"596","DOI":"10.1016\/j.nlm.2011.01.003","article-title":"Alcohol-related amnesia and dementia: animal models have revealed the contributions of different etiological factors on neuropathology, neurochemical dysfunction and cognitive impairment","volume":"96","author":"Vetreno","year":"2011","journal-title":"Neurobiol. Learn. Mem."},{"key":"10.1016\/j.brainres.2017.06.023_b0770","doi-asserted-by":"crossref","first-page":"e113421","DOI":"10.1371\/journal.pone.0113421","article-title":"Adolescent, but not adult, binge ethanol exposure leads to persistent global reductions of choline acetyltransferase expressing neurons in brain","volume":"9","author":"Vetreno","year":"2014","journal-title":"PLoS ONE"},{"key":"10.1016\/j.brainres.2017.06.023_b0775","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1097\/00005072-199805000-00001","article-title":"Huntington disease","volume":"57","author":"Vonsattel","year":"1998","journal-title":"J. Neuropathol. Exp. Neurol."},{"key":"10.1016\/j.brainres.2017.06.023_b0780","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1093\/brain\/awh391","article-title":"Cholinergic systems in progressive supranuclear palsy","volume":"128","author":"Warren","year":"2005","journal-title":"Brain"},{"key":"10.1016\/j.brainres.2017.06.023_b0785","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.parkreldis.2013.08.021","article-title":"Risky driving and pedunculopontine nucleus-thalamic cholinergic denervation in Parkinson disease","volume":"20","author":"Weathers","year":"2014","journal-title":"Parkinsonism Relat. Disord."},{"key":"10.1016\/j.brainres.2017.06.023_b0790","doi-asserted-by":"crossref","first-page":"1237","DOI":"10.1126\/science.7058341","article-title":"Alzheimer's disease and senile dementia: loss of neurons in the basal forebrain","volume":"215","author":"Whitehouse","year":"1982","journal-title":"Science"},{"key":"10.1016\/j.brainres.2017.06.023_b0795","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1002\/ana.410130304","article-title":"Basal forebrain neurons in the dementia of Parkinson disease","volume":"13","author":"Whitehouse","year":"1983","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.brainres.2017.06.023_b0800","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/S0306-4522(98)00216-4","article-title":"Pathological and biochemical consequences of acute and chronic neuroinflammation within the basal forebrain cholinergic system of rats","volume":"88","author":"Willard","year":"1999","journal-title":"Neuroscience"},{"key":"10.1016\/j.brainres.2017.06.023_b0805","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1016\/0361-9230(81)90004-6","article-title":"Cholinergic neurons in the caudate-putamen complex proper are intrinsically organized: a combined Evans blue and acetylcholinesterase analysis","volume":"7","author":"Woolf","year":"1981","journal-title":"Brain Res. Bull."},{"key":"10.1016\/j.brainres.2017.06.023_b0810","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1016\/j.bbr.2009.12.046","article-title":"Cholinergic systems mediate action from movement to higher consciousness","volume":"221","author":"Woolf","year":"2011","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.brainres.2017.06.023_b0815","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/0306-4522(89)90360-6","article-title":"Nerve growth factor receptor is associated with cholinergic neurons of the basal forebrain but not the pontomesencephalon","volume":"30","author":"Woolf","year":"1989","journal-title":"Neuroscience"},{"key":"10.1016\/j.brainres.2017.06.023_b0820","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1016\/0304-3940(89)90391-1","article-title":"The pontomesencephalotegmental cholinergic system does not degenerate in Alzheimer's disease","volume":"96","author":"Woolf","year":"1989","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.brainres.2017.06.023_b0825","doi-asserted-by":"crossref","first-page":"e02444","DOI":"10.7554\/eLife.02444","article-title":"Complete morphologies of basal forebrain cholinergic neurons in the mouse","volume":"3","author":"Wu","year":"2014","journal-title":"Elife"},{"key":"10.1016\/j.brainres.2017.06.023_b0830","doi-asserted-by":"crossref","first-page":"2333","DOI":"10.1172\/JCI119772","article-title":"Binding of beta-amyloid to the p75 neurotrophin receptor induces apoptosis. A possible mechanism for Alzheimer's disease","volume":"100","author":"Yaar","year":"1997","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.brainres.2017.06.023_b0835","doi-asserted-by":"crossref","first-page":"1709","DOI":"10.1523\/JNEUROSCI.22-05-01709.2002","article-title":"Characterization of central inhibitory muscarinic autoreceptors by the use of muscarinic acetylcholine receptor knock-out mice","volume":"22","author":"Zhang","year":"2002","journal-title":"J. Neurosci."},{"key":"10.1016\/j.brainres.2017.06.023_b0840","doi-asserted-by":"crossref","first-page":"69","DOI":"10.3233\/JHD-120026","article-title":"NGF rescues hippocampal cholinergic neuronal markers, restores neurogenesis, and improves the spatial working memory in a mouse model of Huntington's Disease","volume":"2","author":"Zhang","year":"2013","journal-title":"J. Huntingtons Dis."},{"key":"10.1016\/j.brainres.2017.06.023_b0845","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/B978-0-12-385883-2.00010-2","article-title":"Huntington disease and the huntingtin protein","volume":"107","author":"Zheng","year":"2012","journal-title":"Prog. Mol. Biol. Transl. Sci."},{"key":"10.1016\/j.brainres.2017.06.023_b0850","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1002\/ana.410260106","article-title":"The pedunculopontine nucleus in Parkinson's disease","volume":"26","author":"Zweig","year":"1989","journal-title":"Ann. Neurol."}],"container-title":["Brain Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006899317302718?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006899317302718?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,13]],"date-time":"2025-09-13T17:58:26Z","timestamp":1757786306000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006899317302718"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,9]]},"references-count":170,"alternative-id":["S0006899317302718"],"URL":"https:\/\/doi.org\/10.1016\/j.brainres.2017.06.023","relation":{},"ISSN":["0006-8993"],"issn-type":[{"value":"0006-8993","type":"print"}],"subject":[],"published":{"date-parts":[[2017,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The fate of the brain cholinergic neurons in neurodegenerative diseases","name":"articletitle","label":"Article Title"},{"value":"Brain Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.brainres.2017.06.023","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}