{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T15:10:23Z","timestamp":1785769823263,"version":"3.56.0"},"reference-count":49,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2017,12,1]],"date-time":"2017-12-01T00:00:00Z","timestamp":1512086400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"name":"Uludag University Scientific Research Projects Council","award":["KUAP(T)-2013\/76"],"award-info":[{"award-number":["KUAP(T)-2013\/76"]}]}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Brain Research"],"published-print":{"date-parts":[[2017,12]]},"DOI":"10.1016\/j.brainres.2017.09.010","type":"journal-article","created":{"date-parts":[[2017,9,16]],"date-time":"2017-09-16T04:00:39Z","timestamp":1505534439000},"page":"57-68","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":17,"special_numbering":"C","title":["Uridine treatment protects against neonatal brain damage and long-term cognitive deficits caused by hyperoxia"],"prefix":"10.1016","volume":"1676","author":[{"given":"Bulent","family":"Goren","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aysen","family":"Cakir","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cansu","family":"Sevinc","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sema","family":"Serter Kocoglu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Busra","family":"Ocalan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ceren","family":"Oy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zehra","family":"Minbay","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nevzat","family":"Kahveci","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tulin","family":"Alkan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mehmet","family":"Cansev","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.brainres.2017.09.010_b0005","series-title":"Atlas of Prenatal Rat Brain Development","author":"Altman","year":"1995"},{"key":"10.1016\/j.brainres.2017.09.010_b0010","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1111\/j.0953-816X.2004.03451.x","article-title":"Developmental upregulation of MnSOD in rat oligodendrocytes confers protection against oxidative injury","volume":"20","author":"Baud","year":"2004","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.brainres.2017.09.010_b0015","doi-asserted-by":"crossref","first-page":"1713","DOI":"10.1111\/j.1460-9568.2004.03616.x","article-title":"Nitric oxide-induced cell death in developing oligodendrocytes is associated with mitochondrial dysfunction and apoptosis-inducing factor translocation","volume":"20","author":"Baud","year":"2004","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.brainres.2017.09.010_b0020","doi-asserted-by":"crossref","first-page":"12939","DOI":"10.3390\/ijms131012939","article-title":"Erythropoietin modulates autophagy signaling in the developing rat brain in an in vivo model of oxygen-toxicity","volume":"13","author":"Bendix","year":"2012","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.brainres.2017.09.010_b0025","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/j.brainres.2012.09.024","article-title":"Hyperoxia changes the balance of the thioredoxin\/peroxiredoxin system in the neonatal rat brain","volume":"1484","author":"Bendix","year":"2012","journal-title":"Brain Res."},{"key":"10.1016\/j.brainres.2017.09.010_b0030","doi-asserted-by":"crossref","first-page":"e49023","DOI":"10.1371\/journal.pone.0049023","article-title":"Interaction of inflammation and hyperoxia in a rat model of neonatal white matter damage","volume":"7","author":"Brehmer","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.brainres.2017.09.010_b0035","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1016\/j.brainresrev.2006.05.001","article-title":"Uridine and cytidine in the brain: their transport and utilization","volume":"52","author":"Cansev","year":"2006","journal-title":"Brain Res. Rev."},{"key":"10.1016\/j.brainres.2017.09.010_b0040","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1159\/000193394","article-title":"Giving uridine and\/or docosahexaenoic acid orally to rat dams during gestation and nursing increases synaptic elements in brains of weanling pups","volume":"31","author":"Cansev","year":"2009","journal-title":"Dev. Neurosci."},{"key":"10.1016\/j.brainres.2017.09.010_b0045","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.neulet.2013.02.035","article-title":"Neuroprotective effects of uridine in a rat model of neonatal hypoxic-ischemic encephalopathy","volume":"542","author":"Cansev","year":"2013","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.brainres.2017.09.010_b0050","doi-asserted-by":"crossref","first-page":"712","DOI":"10.1203\/00006450-200112000-00014","article-title":"Hypocapnia and other ventilation-related risk factors for cerebral palsy in low birth weight infants","volume":"50","author":"Collins","year":"2001","journal-title":"Pediatr. Res."},{"key":"10.1016\/j.brainres.2017.09.010_b0055","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/0378-3782(79)90022-7","article-title":"Comparative aspects of the brain growth spurt","volume":"3","author":"Dobbing","year":"1979","journal-title":"Early Hum. Dev."},{"key":"10.1016\/j.brainres.2017.09.010_b0060","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1542\/peds.2010-0710","article-title":"Adult outcome of extremely preterm infants","volume":"126","author":"Doyle","year":"2010","journal-title":"Pediatrics"},{"key":"10.1016\/j.brainres.2017.09.010_b0065","doi-asserted-by":"crossref","first-page":"E187","DOI":"10.3390\/ijms18010187","article-title":"Neuroprotection by caffeine in hyperoxia-induced neonatal brain injury","volume":"18","author":"Endesfelder","year":"2017","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.brainres.2017.09.010_b0070","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1016\/j.nbd.2004.07.019","article-title":"Oxygen causes cell death in the developing brain","volume":"17","author":"Felderhoff-Mueser","year":"2004","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.brainres.2017.09.010_b0075","doi-asserted-by":"crossref","first-page":"1236","DOI":"10.1523\/JNEUROSCI.3213-07.2008","article-title":"Hyperoxia causes maturation-dependent cell death in the developing white matter","volume":"28","author":"Gerstner","year":"2008","journal-title":"J. Neurosci."},{"key":"10.1016\/j.brainres.2017.09.010_b0080","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1097\/MOP.0b013e328346577f","article-title":"Pathogenesis and treatment of bronchopulmonary dysplasia","volume":"23","author":"Gien","year":"2011","journal-title":"Curr. Opin. Pediatr."},{"key":"10.1016\/j.brainres.2017.09.010_b0085","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/0165-0270(90)90154-8","article-title":"Beam-walking in rats: studies towards developing an animal model of functional recovery after brain injury","volume":"31","author":"Goldstein","year":"1990","journal-title":"J. Neurosci. Meth."},{"key":"10.1016\/j.brainres.2017.09.010_b0090","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.brainres.2017.01.026","article-title":"Long-term cognitive effects of uridine treatment in a neonatal rat model of hypoxic-ischemic encephalopathy","volume":"1659","author":"Goren","year":"2017","journal-title":"Brain Res."},{"key":"10.1016\/j.brainres.2017.09.010_b0095","doi-asserted-by":"crossref","first-page":"9247493","DOI":"10.1155\/2016\/9247493","article-title":"Erythropoietin restores long-term neurocognitive function involving mechanisms of neuronal plasticity in a model of hyperoxia-induced preterm brain injury","volume":"2016","author":"Hoeber","year":"2016","journal-title":"Oxid. Med. Cell Longev."},{"key":"10.1016\/j.brainres.2017.09.010_b0100","unstructured":"Institute of Medicine (US) Committee on Understanding Premature Birth and Assuring Healthy Outcomes, Mortality and acute complications in preterm infants R.E. Behrman A.S. Butler Preterm Birth: Causes, Consequences, and Prevention 2007 National Academies Press Washington 313 345."},{"key":"10.1016\/j.brainres.2017.09.010_b0105","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1016\/j.brainres.2011.09.044","article-title":"Resveratrol ameliorates hypoxia\/ischemia-induced behavioral deficits and brain injury in the neonatal rat brain","volume":"1425","author":"Karalis","year":"2011","journal-title":"Brain Res."},{"key":"10.1016\/j.brainres.2017.09.010_b0110","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/S0021-9258(19)50785-2","article-title":"The function of cytidine coenzymes in the biosynthesis of phospholipids","volume":"222","author":"Kennedy","year":"1956","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.brainres.2017.09.010_b0115","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1038\/pr.2016.88","article-title":"Intratracheal transplantation of mesenchymal stem cells simultaneously attenuates both lung and brain injuries in hyperoxic newborn rats","volume":"80","author":"Kim","year":"2016","journal-title":"Pediatr. Res."},{"key":"10.1016\/j.brainres.2017.09.010_b0120","first-page":"777","article-title":"Uridine protects against hypoxic-ischemic brain injury by reducing histone deacetylase activity in neonatal rats","volume":"33","author":"Koyuncuoglu","year":"2015","journal-title":"Restor. Neurol. Neurosci."},{"key":"10.1016\/j.brainres.2017.09.010_b0125","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1055\/s-0029-1224101","article-title":"Protective effects of topiramate against hyperoxic brain injury in the developing brain","volume":"40","author":"Kurul","year":"2009","journal-title":"Neuropediatrics"},{"key":"10.1016\/j.brainres.2017.09.010_b0130","doi-asserted-by":"crossref","DOI":"10.1016\/j.ajog.2016.01.004","article-title":"Preterm neonatal morbidity and mortality by gestational age: a contemporary cohort","volume":"215","author":"Manuck","year":"2016","journal-title":"Am. J. Obstet. Gynecol."},{"key":"10.1016\/j.brainres.2017.09.010_b0135","doi-asserted-by":"crossref","first-page":"772","DOI":"10.1001\/jamapediatrics.2016.0781","article-title":"Examination of the pattern of growth of cerebral tissue volumes from hospital discharge to early childhood in very preterm infants","volume":"170","author":"Monson","year":"2016","journal-title":"JAMA Pediatr."},{"key":"10.1016\/j.brainres.2017.09.010_b0140","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/0165-0270(84)90007-4","article-title":"Developments of a water-maze procedure for studying spatial learning in the rat","volume":"11","author":"Morris","year":"1984","journal-title":"J. Neurosci. Meth."},{"key":"10.1016\/j.brainres.2017.09.010_b0145","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1016\/j.ntt.2005.06.005","article-title":"The validity and utility of geotaxis in young rodents","volume":"27","author":"Motz","year":"2005","journal-title":"Neurotoxicol. Teratol."},{"key":"10.1016\/j.brainres.2017.09.010_b0150","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/0306-4522(93)90384-R","article-title":"Effects of fetal hippocampal field grafts on ischaemic-induced deficits in spatial navigation in the water maze","volume":"54","author":"Netto","year":"1993","journal-title":"Neuroscience"},{"key":"10.1016\/j.brainres.2017.09.010_b0155","series-title":"The Rat Brain in Stereotaxic Coordinates","author":"Paxinos","year":"2009"},{"key":"10.1016\/j.brainres.2017.09.010_b0160","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1159\/000454917","article-title":"Hyperoxia and the immature brain","volume":"38","author":"Reich","year":"2016","journal-title":"Dev. Neurosci."},{"issue":"Suppl 1","key":"10.1016\/j.brainres.2017.09.010_b0165","doi-asserted-by":"crossref","first-page":"S46","DOI":"10.1038\/sj.jp.7211475","article-title":"Oxygen and retinopathy of prematurity","volume":"26","author":"Saugstad","year":"2006","journal-title":"J. Perinatol."},{"key":"10.1016\/j.brainres.2017.09.010_b0170","doi-asserted-by":"crossref","first-page":"4327","DOI":"10.1523\/JNEUROSCI.3942-10.2011","article-title":"Cellular changes underlying hyperoxia-induced delay of white matter development","volume":"31","author":"Schmitz","year":"2011","journal-title":"J. Neurosci."},{"key":"10.1016\/j.brainres.2017.09.010_b0175","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1016\/j.bbi.2015.10.004","article-title":"Fingolimod protects against neonatal white matter damage and long-term cognitive deficits caused by hyperoxia","volume":"52","author":"Serdar","year":"2016","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.brainres.2017.09.010_b0180","doi-asserted-by":"crossref","first-page":"e250","DOI":"10.1038\/cddis.2011.133","article-title":"Prevention of neonatal oxygen-induced brain damage by reduction of intrinsic apoptosis","volume":"3","author":"Sifringer","year":"2012","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.brainres.2017.09.010_b0185","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1159\/000232557","article-title":"Erythropoietin attenuates hyperoxia-induced cell death by modulation of inflammatory mediators and matrix metalloproteinases","volume":"31","author":"Sifringer","year":"2009","journal-title":"Dev. Neurosci."},{"key":"10.1016\/j.brainres.2017.09.010_b0190","doi-asserted-by":"crossref","first-page":"792","DOI":"10.1016\/j.bbi.2009.08.010","article-title":"Erythropoietin attenuates hyperoxia-induced oxidative stress in the developing rat brain","volume":"24","author":"Sifringer","year":"2010","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.brainres.2017.09.010_b0195","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1159\/000346723","article-title":"Oxygen toxicity is reduced by acetylcholinesterase inhibition in the developing rat brain","volume":"35","author":"Sifringer","year":"2013","journal-title":"Dev. Neurosci."},{"key":"10.1016\/j.brainres.2017.09.010_b0200","doi-asserted-by":"crossref","first-page":"530371","DOI":"10.1155\/2015\/530371","article-title":"Neuroprotective effect of dexmedetomidine on hyperoxia-induced toxicity in the neonatal rat brain","volume":"2015","author":"Sifringer","year":"2015","journal-title":"Oxid. Med. Cell Longev."},{"key":"10.1016\/j.brainres.2017.09.010_b0205","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1542\/peds.2009-2959","article-title":"Neonatal outcomes of extremely preterm infants from the NICHD Neonatal Research Network","volume":"126","author":"Stoll","year":"2010","journal-title":"Pediatrics"},{"key":"10.1016\/j.brainres.2017.09.010_b0210","doi-asserted-by":"crossref","first-page":"642","DOI":"10.1002\/ana.21367","article-title":"Neonate hippocampal volumes: prematurity, perinatal predictors, and 2-year outcome","volume":"63","author":"Thompson","year":"2008","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.brainres.2017.09.010_b0215","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1203\/00006450-199612000-00012","article-title":"Nucleotides in human milk: sources and metabolism by the newborn infant","volume":"40","author":"Thorell","year":"1996","journal-title":"Pediatric Res."},{"key":"10.1016\/j.brainres.2017.09.010_b0220","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/BF00928361","article-title":"Physiological concentrations of purines and pyrimidines","volume":"140","author":"Traut","year":"1994","journal-title":"Mol. Cell. Biochem."},{"key":"10.1016\/j.brainres.2017.09.010_b0225","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1002\/1098-2779(200102)7:1<56::AID-MRDD1008>3.0.CO;2-A","article-title":"Perinatal brain injury: from pathogenesis to neuroprotection","volume":"7","author":"Volpe","year":"2001","journal-title":"Ment. Retard. Dev. Disabil. Res. Rev."},{"key":"10.1016\/j.brainres.2017.09.010_b0230","doi-asserted-by":"crossref","first-page":"848","DOI":"10.1038\/nprot.2006.116","article-title":"Morris water maze: procedures for assessing spatial and related forms of learning and memory","volume":"1","author":"Vorhees","year":"2006","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.brainres.2017.09.010_b0235","doi-asserted-by":"crossref","first-page":"989","DOI":"10.1016\/S0006-2952(00)00436-6","article-title":"Effect of oral CDP-choline on plasma choline and uridine levels in humans","volume":"60","author":"Wurtman","year":"2000","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.brainres.2017.09.010_b0240","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1016\/j.braindev.2008.01.010","article-title":"Hyperoxic exposure leads to cell death in the developing brain","volume":"30","author":"Yis","year":"2008","journal-title":"Brain Dev."},{"key":"10.1016\/j.brainres.2017.09.010_b0245","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/j.neulet.2008.10.060","article-title":"Effect of erythropoietin on oxygen-induced brain injury in the newborn rat","volume":"448","author":"Yis","year":"2008","journal-title":"Neurosci. Lett."}],"container-title":["Brain Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006899317303955?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006899317303955?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2022,8,2]],"date-time":"2022-08-02T22:41:46Z","timestamp":1659480106000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006899317303955"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,12]]},"references-count":49,"alternative-id":["S0006899317303955"],"URL":"https:\/\/doi.org\/10.1016\/j.brainres.2017.09.010","relation":{},"ISSN":["0006-8993"],"issn-type":[{"value":"0006-8993","type":"print"}],"subject":[],"published":{"date-parts":[[2017,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Uridine treatment protects against neonatal brain damage and long-term cognitive deficits caused by hyperoxia","name":"articletitle","label":"Article Title"},{"value":"Brain Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.brainres.2017.09.010","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}