{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,8]],"date-time":"2026-02-08T07:11:04Z","timestamp":1770534664494,"version":"3.49.0"},"reference-count":32,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2017,12,1]],"date-time":"2017-12-01T00:00:00Z","timestamp":1512086400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Brain Research"],"published-print":{"date-parts":[[2017,12]]},"DOI":"10.1016\/j.brainres.2017.09.012","type":"journal-article","created":{"date-parts":[[2017,9,13]],"date-time":"2017-09-13T11:31:15Z","timestamp":1505302275000},"page":"38-45","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":25,"special_numbering":"C","title":["Tremor dominant Kyoto ( Trdk ) rats carry a missense mutation in the gene encoding the SK2 subunit of small-conductance Ca 2+ -activated K + channel"],"prefix":"10.1016","volume":"1676","author":[{"given":"Takashi","family":"Kuramoto","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mayuko","family":"Yokoe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naofumi","family":"Kunisawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kana","family":"Ohashi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takahito","family":"Miyake","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuki","family":"Higuchi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazuto","family":"Yoshimi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomoji","family":"Mashimo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miyuu","family":"Tanaka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mitusru","family":"Kuwamura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shuji","family":"Kaneko","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Saki","family":"Shimizu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tadao","family":"Serikawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yukihiro","family":"Ohno","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.brainres.2017.09.012_b0005","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1038\/nrneurol.2009.196","article-title":"The clinical approach to movement disorders","volume":"6","author":"Abdo","year":"2010","journal-title":"Nat. Rev. Neurol."},{"key":"10.1016\/j.brainres.2017.09.012_b0010","doi-asserted-by":"crossref","DOI":"10.1093\/hmg\/ddv410","article-title":"SCN4A pore mutation pathogenetically contributes to autosomal dominant essential tremor and may increase susceptibility to epilepsy","author":"Bergareche","year":"2015","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.brainres.2017.09.012_b0015","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1006\/nbdi.2001.0393","article-title":"The frissonnant mutant mouse, a model of dopamino-sensitive, inherited motor syndrome","volume":"8","author":"Callizot","year":"2001","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.brainres.2017.09.012_b0020","doi-asserted-by":"crossref","first-page":"e46688","DOI":"10.1371\/journal.pone.0046688","article-title":"Predicting the functional effect of amino acid substitutions and indels","volume":"7","author":"Choi","year":"2012","journal-title":"PLoS One"},{"issue":"Suppl. 3","key":"10.1016\/j.brainres.2017.09.012_b0025","first-page":"2","article-title":"Consensus statement of the movement disorder society on tremor. Ad Hoc scientific commitee","volume":"13","author":"Deuschl","year":"1998","journal-title":"Mov. Disord."},{"key":"10.1016\/j.brainres.2017.09.012_b0030","doi-asserted-by":"crossref","first-page":"2033","DOI":"10.1002\/mds.22755","article-title":"Essential tremor\u2014neurodegenerative or nondegenerative disease towards a working definition of ET","volume":"24","author":"Deuschl","year":"2009","journal-title":"Mov. Disord."},{"key":"10.1016\/j.brainres.2017.09.012_b0035","doi-asserted-by":"crossref","first-page":"1150","DOI":"10.1016\/S1474-4422(09)70238-8","article-title":"Neuropathological assessment of Parkinson's disease: refining the diagnostic criteria","volume":"8","author":"Dickson","year":"2009","journal-title":"Lancet Neurol."},{"key":"10.1016\/j.brainres.2017.09.012_b0040","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1007\/s11910-009-0041-6","article-title":"An update on essential tremor","volume":"9","author":"Elble","year":"2009","journal-title":"Curr. Neurol. Neurosci. Rep."},{"key":"10.1016\/j.brainres.2017.09.012_b0045","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1007\/s12311-015-0750-0","article-title":"Linking essential tremor to the cerebellum-animal model evidence","volume":"15","author":"Handforth","year":"2016","journal-title":"Cerebellum"},{"key":"10.1016\/j.brainres.2017.09.012_b0050","doi-asserted-by":"crossref","first-page":"5677","DOI":"10.1093\/hmg\/ddv281","article-title":"Missense mutations in TENM4, a regulator of axon guidance and central myelination, cause essential tremor","volume":"24","author":"Hor","year":"2015","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.brainres.2017.09.012_b0055","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/j.brainres.2009.11.027","article-title":"Abnormal myelinogenesis both in the white and gray matter of the attractin-deficient mv rat","volume":"1312","author":"Izawa","year":"2010","journal-title":"Brain Res."},{"key":"10.1016\/j.brainres.2017.09.012_b0060","doi-asserted-by":"crossref","first-page":"1709","DOI":"10.1126\/science.273.5282.1709","article-title":"Small-conductance, calcium-activated potassium channels from mammalian brain","volume":"273","author":"Kohler","year":"1996","journal-title":"Science"},{"key":"10.1016\/j.brainres.2017.09.012_b0065","doi-asserted-by":"crossref","first-page":"774","DOI":"10.1172\/JCI200523625","article-title":"Genetic essential tremor in \u03b3-aminobutyric acidA receptor alpha1 subunit knockout mice","volume":"115","author":"Kralic","year":"2005","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.brainres.2017.09.012_b0070","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1073\/pnas.98.2.559","article-title":"Attractin\/mahogany\/zitter plays a critical role in myelination of the central nervous system","volume":"98","author":"Kuramoto","year":"2001","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.brainres.2017.09.012_b0075","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1538\/expanim.60.57","article-title":"Kyoto rhino rats derived by ENU mutagenesis undergo congenital hair loss and exhibit focal glomerulosclerosis","volume":"60","author":"Kuramoto","year":"2011","journal-title":"Exp. Anim."},{"key":"10.1016\/j.brainres.2017.09.012_b0080","doi-asserted-by":"crossref","first-page":"e1001262","DOI":"10.1371\/journal.pgen.1001262","article-title":"A mutation in the gene encoding mitochondrial Mg2+ channel MRS2 results in demyelination in the rat","volume":"7","author":"Kuramoto","year":"2011","journal-title":"PLoS Genet."},{"key":"10.1016\/j.brainres.2017.09.012_b0085","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/0300-483X(95)03120-5","article-title":"Compared toxicity of the potassium channel blockers, apamin and dendrotoxin","volume":"104","author":"Lallement","year":"1995","journal-title":"Toxicology"},{"key":"10.1016\/j.brainres.2017.09.012_b0090","doi-asserted-by":"crossref","unstructured":"Lane, E.L., Dunnett, S.B., 2011. Animal models of movement disorders, Vol., Humana Press, New York.","DOI":"10.1007\/978-1-61779-301-1"},{"key":"10.1016\/j.brainres.2017.09.012_b0095","article-title":"Identification of candidate genes for familial early-onset essential tremor","author":"Liu","year":"2015","journal-title":"Eur. J. Hum. Genet."},{"key":"10.1016\/j.brainres.2017.09.012_b0100","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1038\/ng0508-514","article-title":"An ENU-induced mutant archive for gene targeting in rats","volume":"40","author":"Mashimo","year":"2008","journal-title":"Nat. Genet."},{"key":"10.1016\/j.brainres.2017.09.012_b0105","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1016\/j.ajhg.2012.07.002","article-title":"Exome sequencing identifies FUS mutations as a cause of essential tremor","volume":"91","author":"Merner","year":"2012","journal-title":"Am. J. Hum. Genet."},{"key":"10.1016\/j.brainres.2017.09.012_b0110","doi-asserted-by":"crossref","first-page":"1536","DOI":"10.1152\/jn.00630.2003","article-title":"Cloning and expression of a small-conductance Ca2+-activated K+ channel from the mouse cochlea: coexpression with \u03b19\/\u03b110 acetylcholine receptors","volume":"91","author":"Nie","year":"2004","journal-title":"J. Neurophysiol."},{"key":"10.1016\/j.brainres.2017.09.012_b0115","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1016\/j.neuropharm.2008.06.005","article-title":"Anticataleptic 8-OH-DPAT preferentially counteracts with haloperidol-induced Fos expression in the dorsolateral striatum and the core region of the nucleus accumbens","volume":"55","author":"Ohno","year":"2008","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.brainres.2017.09.012_b0120","doi-asserted-by":"crossref","first-page":"e0123529","DOI":"10.1371\/journal.pone.0123529","article-title":"Hcn1 is a tremorgenic genetic component in a rat model of essential tremor","volume":"10","author":"Ohno","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.brainres.2017.09.012_b0125","doi-asserted-by":"crossref","first-page":"560","DOI":"10.1038\/ng.124","article-title":"SNP and haplotype mapping for genetic analysis in the rat","volume":"40","author":"Saar","year":"2008","journal-title":"Nat. Genet."},{"key":"10.1016\/j.brainres.2017.09.012_b0130","doi-asserted-by":"crossref","unstructured":"Sanchez, E., Bergareche, A., Krebs, C.E., Gorostidi, A., Makarov, V., Ruiz-Martinez, J., Chorny, A., Lopez de Munain, A., Marti-Masso, J.F., Paisan-Ruiz, C., 2015. SORT1 mutation resulting in sortilin deficiency and p75NTR upregulation in a family with essential tremor. ASN Neuro. 7.","DOI":"10.1177\/1759091415598290"},{"key":"10.1016\/j.brainres.2017.09.012_b0135","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.pneurobio.2014.05.001","article-title":"Genetics of essential tremor: from phenotype to genes, insights from both human and mouse studies","volume":"119\u2013120","author":"Schmouth","year":"2014","journal-title":"Prog. Neurobiol."},{"key":"10.1016\/j.brainres.2017.09.012_b0140","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1006\/mcne.2000.0842","article-title":"Differential distribution of three Ca2+-activated K+ channel subunits, SK1, SK2, and SK3, in the adult rat central nervous system","volume":"15","author":"Stocker","year":"2000","journal-title":"Mol. Cell Neurosci."},{"key":"10.1016\/j.brainres.2017.09.012_b0145","doi-asserted-by":"crossref","first-page":"4382","DOI":"10.1073\/pnas.89.10.4382","article-title":"A leucine-to-proline mutation in the putative first transmembrane domain of the 22-kDa peripheral myelin protein in the trembler-J mouse","volume":"89","author":"Suter","year":"1992","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.brainres.2017.09.012_b0150","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1007\/s10048-008-0136-2","article-title":"Behavioral effects of a deletion in Kcnn2, the gene encoding the SK2 subunit of small-conductance Ca2+-activated K+ channels","volume":"9","author":"Szatanik","year":"2008","journal-title":"Neurogenetics"},{"key":"10.1016\/j.brainres.2017.09.012_b0155","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1016\/j.brainres.2012.09.037","article-title":"Abnormal myelinogenesis in the central nervous system of the VF mutant rat with recoverable tremor","volume":"1488","author":"Tanaka","year":"2012","journal-title":"Brain Res."},{"issue":"Suppl 1","key":"10.1016\/j.brainres.2017.09.012_b0160","doi-asserted-by":"crossref","first-page":"S176","DOI":"10.1016\/j.parkreldis.2015.09.022","article-title":"Genetics of essential tremor","volume":"22","author":"Tio","year":"2016","journal-title":"Parkinsonism Relat. Disord."}],"container-title":["Brain Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006899317303979?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006899317303979?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,8,27]],"date-time":"2018-08-27T14:29:11Z","timestamp":1535380151000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006899317303979"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,12]]},"references-count":32,"alternative-id":["S0006899317303979"],"URL":"https:\/\/doi.org\/10.1016\/j.brainres.2017.09.012","relation":{},"ISSN":["0006-8993"],"issn-type":[{"value":"0006-8993","type":"print"}],"subject":[],"published":{"date-parts":[[2017,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Tremor dominant Kyoto (Trdk) rats carry a missense mutation in the gene encoding the SK2 subunit of small-conductance Ca2+-activated K+ channel","name":"articletitle","label":"Article Title"},{"value":"Brain Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.brainres.2017.09.012","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}