{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T17:42:10Z","timestamp":1787506930503,"version":"build-2736575974"},"reference-count":27,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2018,1,1]],"date-time":"2018-01-01T00:00:00Z","timestamp":1514764800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100001691","name":"JSPS","doi-asserted-by":"publisher","award":["17K10815"],"award-info":[{"award-number":["17K10815"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009619","name":"AMED","doi-asserted-by":"publisher","award":["J160001258"],"award-info":[{"award-number":["J160001258"]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Brain Research"],"published-print":{"date-parts":[[2018,1]]},"DOI":"10.1016\/j.brainres.2017.11.013","type":"journal-article","created":{"date-parts":[[2017,11,23]],"date-time":"2017-11-23T02:18:15Z","timestamp":1511403495000},"page":"39-44","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":50,"special_numbering":"C","title":["Increased serum production of soluble CD163 and CXCL5 in patients with moyamoya disease: Involvement of intrinsic immune reaction in its pathogenesis"],"prefix":"10.1016","volume":"1679","author":[{"given":"Miki","family":"Fujimura","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taku","family":"Fujimura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aya","family":"Kakizaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mika","family":"Sato-Maeda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kuniyasu","family":"Niizuma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasutake","family":"Tomata","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Setsuya","family":"Aiba","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Teiji","family":"Tominaga","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.brainres.2017.11.013_b0005","doi-asserted-by":"crossref","first-page":"2616","DOI":"10.1161\/STROKEAHA.115.009854","article-title":"Intravenous bone marrow stem cell grafts preferentially migrate to spleen and abrogate chronic inflammation in stroke","volume":"46","author":"Acosta","year":"2015","journal-title":"Stroke"},{"key":"10.1016\/j.brainres.2017.11.013_b0010","doi-asserted-by":"crossref","first-page":"1997","DOI":"10.1161\/STROKEAHA.111.000307","article-title":"Moyamoya disease in a primary white, Midwestern US population. Increased prevalence of autoimmune disease","volume":"44","author":"Bower","year":"2013","journal-title":"Stroke"},{"key":"10.1016\/j.brainres.2017.11.013_b0015","doi-asserted-by":"crossref","first-page":"291","DOI":"10.23736\/S0390-5616.16.03921-7","article-title":"Stem cell therapy for sequestering neuroinflammation in traumatic brain injury: an update on exosome-targeting to the spleen","volume":"61","author":"Crowley","year":"2017","journal-title":"J. Neurosurg. Sci."},{"key":"10.1016\/j.brainres.2017.11.013_b0020","doi-asserted-by":"crossref","first-page":"65","DOI":"10.5853\/jos.2014.16.2.65","article-title":"Genetics and biomarkers of moyamoya disease: Significance of RNF213 as a susceptibility gene","volume":"16","author":"Fujimura","year":"2014","journal-title":"J. Stroke"},{"key":"10.1016\/j.brainres.2017.11.013_b0025","doi-asserted-by":"crossref","first-page":"189","DOI":"10.2176\/nmc.ra.2014-0307","article-title":"Diagnosis of moyamoya disease: International standard and regional differences","volume":"55","author":"Fujimura","year":"2015","journal-title":"Neurol. Med. Chir. (Tokyo)"},{"key":"10.1016\/j.brainres.2017.11.013_b0030","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1016\/j.surneu.2008.10.009","article-title":"Increased expression of serum Matrix Metalloproteinase-9 in patients with moyamoya disease","volume":"72","author":"Fujimura","year":"2009","journal-title":"Surg. Neurol."},{"key":"10.1016\/j.brainres.2017.11.013_b0035","doi-asserted-by":"crossref","unstructured":"Fujimura, T., Hidaka, T., Kambayashi, Y., Furudate, S., Kakizaki, A., Tono, H., Tsukada, A., Haga, T., Hashimoto, A., Morimoto, R., Yamaguchi, T., Takano, T., Aiba, S., 2017. Phase I study of nivolumab combined with IFN-\u03b2 for patients with advanced melanoma. Oncotarget (in press).","DOI":"10.18632\/oncotarget.17090"},{"key":"10.1016\/j.brainres.2017.11.013_b0040","doi-asserted-by":"crossref","unstructured":"Fujimura, T.,Kakizaki, A.,Furudate, S.,Aiba, S., 2016a. A possible interaction between periostin and CD163+ skin-resident macrophages in pemphigus vulgaris and bullous pemphigoid. Exp. Dermatol. [Epub ahead of print].","DOI":"10.1016\/j.jid.2016.06.270"},{"key":"10.1016\/j.brainres.2017.11.013_b0045","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/j.jdermsci.2016.05.015","article-title":"Tumor-associated macrophages in skin: how to treat their heterogeneity and plasticity","volume":"83","author":"Fujimura","year":"2016","journal-title":"J Dermatol. Sci."},{"key":"10.1016\/j.brainres.2017.11.013_b0050","doi-asserted-by":"crossref","unstructured":"Fukui, M., 1997. Guidelines for the diagnosis and treatment of spontaneous occlusion of the circle of Willis (\u2018moyamoya\u2019 disease). Research Committee on Spontaneous Occlusion of the Circle of Willis (Moyamoya Disease) of the Ministry of Health and Walfare, Japan. Clin. Neurol. Neurosurg. 99 Suppl 2, S238\u2013S240.","DOI":"10.1016\/S0303-8467(97)00082-6"},{"key":"10.1016\/j.brainres.2017.11.013_b0055","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1016\/j.immuni.2010.05.007","article-title":"Alternative activation of macrophages: mechanism and functions","volume":"32","author":"Gordon","year":"2010","journal-title":"Immunity"},{"key":"10.1016\/j.brainres.2017.11.013_b0060","first-page":"498","article-title":"Macrophage activity assessed by soluble CD163 in early rheumatoid arthritis: association with disease activity but different response patterns to synthetic and biologic DMARDs","volume":"33","author":"Greisen","year":"2015","journal-title":"Clin. Exp. Rheumatol."},{"key":"10.1016\/j.brainres.2017.11.013_b0065","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1038\/jhg.2010.132","article-title":"A genome-wide association study identifies RNF213 as the first Moyamoya disease gene","volume":"56","author":"Kamada","year":"2011","journal-title":"J. Hum. Genet."},{"key":"10.1016\/j.brainres.2017.11.013_b0070","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1136\/jnnp.2009.191817","article-title":"Plasma matrix metalloproteinases, cytokines and angiogenic factors in moyamoya disease","volume":"81","author":"Kang","year":"2010","journal-title":"J. Neurol. Neurosurg. Psychiatry."},{"key":"10.1016\/j.brainres.2017.11.013_b0075","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.brainres.2016.03.009","article-title":"Temporal profile of magnetic resonance angiography and decreased ratio of regulatory T cells after immunological adjuvant administration to mice lacking RNF213, a susceptibility gene for moyamoya disease","volume":"1642","author":"Kanoke","year":"2016","journal-title":"Brain. Res."},{"key":"10.1016\/j.brainres.2017.11.013_b0080","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1016\/j.brainres.2015.07.039","article-title":"Temporal profile of the vascular anatomy evaluated by 9.4-tesla magnetic resonance angiography and histological analysis in mice with the R4859K mutation of RNF213, the susceptibility gene for moyamoya disease","volume":"1624","author":"Kanoke","year":"2015","journal-title":"Brain Res."},{"key":"10.1016\/j.brainres.2017.11.013_b0085","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1161\/STROKEAHA.109.562264","article-title":"Association of thyroid autoantibodies with moyamoya-type cerebrovascular disease: a prospective study","volume":"41","author":"Kim","year":"2010","journal-title":"Stroke"},{"key":"10.1016\/j.brainres.2017.11.013_b0090","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1161\/STROKEAHA.107.490714","article-title":"Prevalence and clinicoepidemiological features of moyamoya disease in Japan: findings from a nationwide epidemiological survey","volume":"39","author":"Kuriyama","year":"2008","journal-title":"Stroke"},{"key":"10.1016\/j.brainres.2017.11.013_b0095","doi-asserted-by":"crossref","first-page":"1138","DOI":"10.1161\/STROKEAHA.110.608471","article-title":"Increased thyroid function and elevated thyroid autoantibodies in pediatric patients with moyamoya disease. A case-control study","volume":"42","author":"Li","year":"2011","journal-title":"Stroke"},{"key":"10.1016\/j.brainres.2017.11.013_b0100","doi-asserted-by":"crossref","first-page":"e22542","DOI":"10.1371\/journal.pone.0022542","article-title":"Identification of RNF213 as a susceptibility gene for moyamoya disease and its possible role in vascular development","volume":"6","author":"Liu","year":"2011","journal-title":"PLoS One"},{"key":"10.1016\/j.brainres.2017.11.013_b0105","doi-asserted-by":"crossref","first-page":"7303","DOI":"10.4049\/jimmunol.177.10.7303","article-title":"Transcriptional profiling of the human monocyte-to-macrophage differentiation and polarization: new molecules and patterns of gene expression","volume":"177","author":"Martinez","year":"2006","journal-title":"J. Immunol."},{"key":"10.1016\/j.brainres.2017.11.013_b0110","doi-asserted-by":"crossref","first-page":"936","DOI":"10.1038\/ni.1920","article-title":"The Jmjd3-Irf4 axis regulates M2 macrophage polarization and host responses against helminth infection","volume":"11","author":"Satoh","year":"2010","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.brainres.2017.11.013_b0115","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/j.brainres.2014.01.011","article-title":"Temporal profile of the vascular anatomy evaluated by 9.4-tesla magnetic resonance angiography and histopathological analysis in mice lacking RNF213; a susceptibility gene for moyamoya disease","volume":"1552","author":"Sonobe","year":"2014","journal-title":"Brain Res."},{"key":"10.1016\/j.brainres.2017.11.013_b0120","doi-asserted-by":"crossref","first-page":"1650","DOI":"10.1016\/j.molimm.2010.02.008","article-title":"Scavenger receptor CD163, a Jack-of-all-trades and potential target for cell-directed therapy","volume":"47","author":"Van Gorp","year":"2010","journal-title":"Mol. Immunol."},{"key":"10.1016\/j.brainres.2017.11.013_b0125","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1007\/s10875-006-9022-6","article-title":"Matrix metalloproteinase-9 and autoimmune diseases","volume":"26","author":"Ram","year":"2006","journal-title":"J. Clin. Immunol."},{"key":"10.1016\/j.brainres.2017.11.013_b0130","doi-asserted-by":"crossref","unstructured":"Research Committee on the Pathology and Treatment of Spontaneous Occlusion of the Circle of Willis, Health Labour Sciences Research Grant for Research on Measures for Intractable Diseases, 2012. Guidelines for diagnosis and treatment of moyamoya disease (Spontaneous Occlusion of the Circle of Willis). Neurol Med. Chir. (Tokyo) 52, 245\u2013266.","DOI":"10.2176\/nmc.52.245"},{"key":"10.1016\/j.brainres.2017.11.013_b0135","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1001\/archneur.1969.00480090076012","article-title":"Cerebrovascular \u2018moyamoya\u2019 disease. Disease showing abnormal net-like vessels in base of brain","volume":"20","author":"Suzuki","year":"1969","journal-title":"Arch. Neurol."}],"container-title":["Brain Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006899317305085?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006899317305085?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2022,8,7]],"date-time":"2022-08-07T22:59:49Z","timestamp":1659913189000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006899317305085"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,1]]},"references-count":27,"alternative-id":["S0006899317305085"],"URL":"https:\/\/doi.org\/10.1016\/j.brainres.2017.11.013","relation":{},"ISSN":["0006-8993"],"issn-type":[{"value":"0006-8993","type":"print"}],"subject":[],"published":{"date-parts":[[2018,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Increased serum production of soluble CD163 and CXCL5 in patients with moyamoya disease: Involvement of intrinsic immune reaction in its pathogenesis","name":"articletitle","label":"Article Title"},{"value":"Brain Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.brainres.2017.11.013","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}