{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,17]],"date-time":"2026-02-17T21:04:15Z","timestamp":1771362255190,"version":"3.50.1"},"reference-count":31,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2018,2,1]],"date-time":"2018-02-01T00:00:00Z","timestamp":1517443200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"name":"Aarhus University Department of Nuclear Medicine and PET Center"}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Brain Research"],"published-print":{"date-parts":[[2018,2]]},"DOI":"10.1016\/j.brainres.2017.12.018","type":"journal-article","created":{"date-parts":[[2017,12,16]],"date-time":"2017-12-16T17:54:47Z","timestamp":1513446887000},"page":"110-114","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":12,"special_numbering":"C","title":["Acute in vivo effect of valproic acid on the GABAergic system in rat brain: A [ 11 C]Ro15-4513 microPET study"],"prefix":"10.1016","volume":"1680","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4876-9049","authenticated-orcid":false,"given":"Freja","family":"Bertelsen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anne M.","family":"Landau","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karina H.","family":"Vase","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jan","family":"Jacobsen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J\u00f8rgen","family":"Scheel-Kr\u00fcger","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arne","family":"M\u00f8ller","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.brainres.2017.12.018_b0005","doi-asserted-by":"crossref","first-page":"2306","DOI":"10.2174\/15680266113136660162","article-title":"Discovering new treatments for Alzheimer's disease by repurposing approved medications","volume":"13","author":"Appleby","year":"2013","journal-title":"Curr. Top. Med. Chem."},{"key":"10.1016\/j.brainres.2017.12.018_b0010","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1113\/jphysiol.1984.sp015306","article-title":"Changes in benzodiazepine receptor-binding as seen autoradiographically in the central nervous-system of the spastic mouse","volume":"352","author":"Biscoe","year":"1984","journal-title":"J. Physiol. London"},{"key":"10.1016\/j.brainres.2017.12.018_b0015","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1038\/294472a0","article-title":"GABA reduces binding of 3H-methyl beta-carboline-3-carboxylate to brain benzodiazepine receptors","volume":"294","author":"Braestrup","year":"1981","journal-title":"Nature"},{"key":"10.1016\/j.brainres.2017.12.018_b0020","doi-asserted-by":"crossref","first-page":"1241","DOI":"10.1126\/science.6281892","article-title":"Interaction of convulsive ligands with benzodiazepine receptors","volume":"216","author":"Braestrup","year":"1982","journal-title":"Science"},{"key":"10.1016\/j.brainres.2017.12.018_b0025","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1002\/cne.10102","article-title":"Intact sorting, targeting, and clustering of gamma-aminobutyric acid A receptor subtypes in hippocampal neurons in vitro","volume":"443","author":"Brunig","year":"2002","journal-title":"J. Comp. Neurol."},{"key":"10.1016\/j.brainres.2017.12.018_b0030","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1124\/pr.111.005512","article-title":"Therapeutic potential of mood stabilizers lithium and valproic acid: beyond bipolar disorder","volume":"65","author":"Chiu","year":"2013","journal-title":"Pharmacol. Rev."},{"issue":"Suppl. 2","key":"10.1016\/j.brainres.2017.12.018_b0035","first-page":"74","article-title":"Schizophrenia and valproate","volume":"37","author":"Citrome","year":"2003","journal-title":"Psychopharmacol. Bull."},{"key":"10.1016\/j.brainres.2017.12.018_b0040","first-page":"263","article-title":"The role of GABAA receptors in mediating the effects of alcohol in the central nervous system","volume":"28","author":"Davies","year":"2003","journal-title":"J. Psychiatry Neurosci."},{"key":"10.1016\/j.brainres.2017.12.018_b0045","doi-asserted-by":"crossref","first-page":"e32443","DOI":"10.1371\/journal.pone.0032443","article-title":"[11C]flumazenil binding is increased in a dose-dependent manner with tiagabine-induced elevations in GABA levels","volume":"7","author":"Frankle","year":"2012","journal-title":"PLoS ONE"},{"key":"10.1016\/j.brainres.2017.12.018_b0050","doi-asserted-by":"crossref","first-page":"624","DOI":"10.1038\/npp.2008.104","article-title":"Tiagabine increases [11C]flumazenil binding in cortical brain regions in healthy control subjects","volume":"34","author":"Frankle","year":"2009","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.brainres.2017.12.018_b0055","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1016\/0014-2999(87)90076-8","article-title":"[3H]Ro 15-1788 binding to benzodiazepine receptors in mouse brain in vivo: marked enhancement by GABA agonists and other CNS drugs","volume":"142","author":"Koe","year":"1987","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.brainres.2017.12.018_b0060","doi-asserted-by":"crossref","first-page":"878","DOI":"10.1097\/00004647-200207000-00013","article-title":"Imaging the GABA-benzodiazepine receptor subtype containing the alpha5-subunit in vivo with [11C]Ro15 4513 positron emission tomography","volume":"22","author":"Lingford-Hughes","year":"2002","journal-title":"J. Cereb. Blood Flow Metab."},{"key":"10.1016\/j.brainres.2017.12.018_b0065","doi-asserted-by":"crossref","first-page":"e00484","DOI":"10.1002\/brb3.484","article-title":"Exogenous dopamine reduces GABA receptor availability in the human brain","volume":"6","author":"Lou","year":"2016","journal-title":"Brain Behav."},{"key":"10.1016\/j.brainres.2017.12.018_b0070","doi-asserted-by":"crossref","first-page":"4362","DOI":"10.1038\/srep04362","article-title":"Soybean greatly reduces valproic acid plasma concentrations: a food-drug interaction study","volume":"4","author":"Marahatta","year":"2014","journal-title":"Sci. Rep."},{"key":"10.1016\/j.brainres.2017.12.018_b0075","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/j.neuropharm.2012.04.008","article-title":"The brain GABA-benzodiazepine receptor alpha-5 subtype in autism spectrum disorder: a pilot [(11)C]Ro15-4513 positron emission tomography study","volume":"68","author":"Mendez","year":"2013","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.brainres.2017.12.018_b0080","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/0014-2999(88)90461-X","article-title":"'GABA shift' in vivo: enhancement of benzodiazepine binding in vivo by modulation of endogenous GABA","volume":"148","author":"Miller","year":"1988","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.brainres.2017.12.018_b0085","doi-asserted-by":"crossref","first-page":"1328","DOI":"10.1042\/BST0371328","article-title":"Role of GABAA receptors in cognition","volume":"37","author":"Mohler","year":"2009","journal-title":"Biochem. Soc. Trans."},{"key":"10.1016\/j.brainres.2017.12.018_b0090","article-title":"Quantification of [11C]Ro15-4513 GABAAalpha5 specific binding and regional selectivity in humans","author":"Myers","year":"2016","journal-title":"J. Cereb. Blood Flow Metab."},{"key":"10.1016\/j.brainres.2017.12.018_b0095","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1097\/00001756-199612200-00024","article-title":"A subclass of GABAA\/benzodiazepine receptor exclusively localized in the limbic system","volume":"8","author":"Onoe","year":"1996","journal-title":"Neuroreport"},{"key":"10.1016\/j.brainres.2017.12.018_b0100","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1016\/j.biopsych.2010.03.023","article-title":"Higher serotonin 1A binding in a second major depression cohort: modeling and reference region considerations","volume":"68","author":"Parsey","year":"2010","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.brainres.2017.12.018_b0105","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1016\/0278-5846(91)90019-W","article-title":"Modulation of benzodiazepine agonist and inverse-agonist receptor binding by GABA during ethanol withdrawal","volume":"15","author":"Prather","year":"1991","journal-title":"Prog. Neuro-Psychopharmacol. Biol. Psychiatry"},{"key":"10.1016\/j.brainres.2017.12.018_b0110","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1002\/syn.21780","article-title":"Influence of agonist induced internalization on [3H]Ro15-4513 binding-an application to imaging fluctuations in endogenous GABA with positron emission tomography","volume":"69","author":"Quelch","year":"2015","journal-title":"Synapse"},{"issue":"Suppl 2","key":"10.1016\/j.brainres.2017.12.018_b0115","first-page":"14","article-title":"The GABA-benzodiazepine receptor complex: structure, function, and role in anxiety","volume":"66","author":"Roy-Byrne","year":"2005","journal-title":"J. Clin. Psychiatry"},{"key":"10.1016\/j.brainres.2017.12.018_b0120","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1007\/s10552-016-0737-2","article-title":"Antiepileptic drugs with histone deacetylase inhibition activity and prostate cancer risk: a population-based case-control study","volume":"27","author":"Salminen","year":"2016","journal-title":"Cancer Causes Control"},{"key":"10.1016\/j.brainres.2017.12.018_b0125","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/S0031-6997(25)06840-1","article-title":"Structure and pharmacology of gamma-aminobutyric acid A receptor subtypes","volume":"47","author":"Sieghart","year":"1995","journal-title":"Pharmacol. Rev."},{"key":"10.1016\/j.brainres.2017.12.018_b0130","doi-asserted-by":"crossref","first-page":"40224","DOI":"10.1074\/jbc.R112.386664","article-title":"Structure, function, and modulation of GABA(A) receptors","volume":"287","author":"Sigel","year":"2012","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.brainres.2017.12.018_b0135","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1007\/978-1-4757-6376-8_7","article-title":"GABA and its receptors in epilepsy","volume":"548","author":"Sperk","year":"2004","journal-title":"Adv. Exp. Med. Biol."},{"key":"10.1016\/j.brainres.2017.12.018_b0140","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1016\/j.neuroimage.2014.05.035","article-title":"Acute increases in synaptic GABA detectable in the living human brain: a [(1)(1)C]Ro15-4513 PET study","volume":"99","author":"Stokes","year":"2014","journal-title":"Neuroimage"},{"key":"10.1016\/j.brainres.2017.12.018_b0145","doi-asserted-by":"crossref","first-page":"1236","DOI":"10.1016\/S0022-3565(25)24693-6","article-title":"The benzodiazepine\/alcohol antagonist Ro 15-4513: binding to a GABAA receptor subtype that is insensitive to diazepam","volume":"257","author":"Turner","year":"1991","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.brainres.2017.12.018_b0150","doi-asserted-by":"crossref","first-page":"1023","DOI":"10.2165\/11596280-000000000-00000","article-title":"Combination therapy for neuropathic pain: a review of current evidence","volume":"25","author":"Vorobeychik","year":"2011","journal-title":"CNS Drugs"},{"key":"10.1016\/j.brainres.2017.12.018_b0155","doi-asserted-by":"crossref","first-page":"888","DOI":"10.1038\/jcbfm.2013.26","article-title":"Reference region approaches in PET: a comparative study on multiple radioligands","volume":"33","author":"Zanderigo","year":"2013","journal-title":"J. Cereb. Blood Flow Metab."}],"container-title":["Brain Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006899317305528?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006899317305528?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,6,28]],"date-time":"2025-06-28T22:17:49Z","timestamp":1751149069000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006899317305528"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,2]]},"references-count":31,"alternative-id":["S0006899317305528"],"URL":"https:\/\/doi.org\/10.1016\/j.brainres.2017.12.018","relation":{},"ISSN":["0006-8993"],"issn-type":[{"value":"0006-8993","type":"print"}],"subject":[],"published":{"date-parts":[[2018,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Acute in vivo effect of valproic acid on the GABAergic system in rat brain: A [11C]Ro15-4513 microPET study","name":"articletitle","label":"Article Title"},{"value":"Brain Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.brainres.2017.12.018","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}