{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T09:25:32Z","timestamp":1785403532149,"version":"3.56.0"},"reference-count":69,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,1,1]],"date-time":"2019-01-01T00:00:00Z","timestamp":1546300800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Brain Research"],"published-print":{"date-parts":[[2019,1]]},"DOI":"10.1016\/j.brainres.2017.12.028","type":"journal-article","created":{"date-parts":[[2017,12,21]],"date-time":"2017-12-21T02:49:23Z","timestamp":1513824563000},"page":"29-37","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":34,"special_numbering":"C","title":["The locus coeruleus neuroprotective drug vindeburnol normalizes behavior in the 5xFAD transgenic mouse model of Alzheimer\u2019s disease"],"prefix":"10.1016","volume":"1702","author":[{"given":"David","family":"Braun","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Douglas L.","family":"Feinstein","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.brainres.2017.12.028_b0005","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1016\/j.bbr.2012.03.024","article-title":"Object recognition testing: statistical considerations","volume":"232","author":"Akkerman","year":"2012","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.brainres.2017.12.028_b0010","doi-asserted-by":"crossref","first-page":"3720","DOI":"10.1074\/jbc.M116.763813","article-title":"Iso-alpha-acids, bitter components of beer, prevent inflammation and cognitive decline induced in a mouse model of Alzheimer's disease","volume":"292","author":"Ano","year":"2017","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.brainres.2017.12.028_b0015","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1007\/BF00274983","article-title":"The human locus coeruleus complex: an immunohistochemical and three dimensional reconstruction study","volume":"77","author":"Baker","year":"1989","journal-title":"Exp. Brain. Res."},{"key":"10.1016\/j.brainres.2017.12.028_b0020","doi-asserted-by":"crossref","first-page":"342","DOI":"10.2174\/1570159X12666140828220938","article-title":"Noradrenergic regulation of glial activation: molecular mechanisms and therapeutic implications","volume":"12","author":"Braun","year":"2014","journal-title":"Curr. Neuropharmacol."},{"key":"10.1016\/j.brainres.2017.12.028_b0025","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1002\/(SICI)1098-2396(199605)23:1<28::AID-SYN4>3.0.CO;2-J","article-title":"Noradrenergic mechanisms in stress and anxiety: I. Preclinical studies","volume":"23","author":"Bremner","year":"1996","journal-title":"Synapse"},{"key":"10.1016\/j.brainres.2017.12.028_b0030","doi-asserted-by":"crossref","first-page":"331","DOI":"10.14336\/AD.2015.0825","article-title":"The involvement of BDNF, NGF and GDNF in aging and Alzheimer's disease","volume":"6","author":"Budni","year":"2015","journal-title":"Aging Dis."},{"key":"10.1016\/j.brainres.2017.12.028_b0035","doi-asserted-by":"crossref","first-page":"840","DOI":"10.1016\/j.neuroscience.2010.09.015","article-title":"Aggressive behavior during social interaction in mice is controlled by the modulation of tyrosine hydroxylase expression in the prefrontal cortex","volume":"171","author":"Cambon","year":"2010","journal-title":"Neuroscience"},{"key":"10.1016\/j.brainres.2017.12.028_b0040","doi-asserted-by":"crossref","unstructured":"Chalermpalanupap, T., et al., 2017. Locus coeruleus ablation exacerbates cognitive deficits, neuropathology, and lethality in P301S tau transgenic mice. J. Neurosci.","DOI":"10.1523\/JNEUROSCI.1483-17.2017"},{"key":"10.1016\/j.brainres.2017.12.028_b0045","unstructured":"Charney, D.S., et al., 1990. Noradrenergic function in panic disorder. J. Clin. Psychiatry 51 Suppl A, 5\u201311."},{"key":"10.1016\/j.brainres.2017.12.028_b0050","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1016\/j.bbr.2013.02.008","article-title":"Novel behavioural characteristics of the APP(Swe)\/PS1DeltaE9 transgenic mouse model of Alzheimer's disease","volume":"245","author":"Cheng","year":"2013","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.brainres.2017.12.028_b0055","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/j.bbr.2013.11.046","article-title":"Novel behavioural characteristics of female APPSwe\/PS1DeltaE9 double transgenic mice","volume":"260","author":"Cheng","year":"2014","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.brainres.2017.12.028_b0060","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1016\/S0733-8619(05)70228-0","article-title":"Neurobehavioral and neuropsychiatric symptoms in Alzheimer's disease: characteristics and treatment","volume":"18","author":"Chung","year":"2000","journal-title":"Neurol. Clin."},{"key":"10.1016\/j.brainres.2017.12.028_b0065","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/j.neurobiolaging.2016.08.012","article-title":"Selective noradrenaline depletion impairs working memory and hippocampal neurogenesis","volume":"48","author":"Coradazzi","year":"2016","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.brainres.2017.12.028_b0070","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1007\/s002130050327","article-title":"Behavioral phenotypes of inbred mouse strains: implications and recommendations for molecular studies","volume":"132","author":"Crawley","year":"1997","journal-title":"Psychopharmacology"},{"key":"10.1016\/j.brainres.2017.12.028_b0075","doi-asserted-by":"crossref","first-page":"541","DOI":"10.3389\/fnins.2016.00541","article-title":"Monoaminergic and histaminergic strategies and treatments in brain diseases","volume":"10","author":"Di Giovanni","year":"2016","journal-title":"Front. Neurosci."},{"key":"10.1016\/j.brainres.2017.12.028_b0080","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/j.brainres.2004.07.052","article-title":"Spatial learning and exploration of environmental stimuli in 24-month-old female APP23 transgenic mice with the Swedish mutation","volume":"1024","author":"Dumont","year":"2004","journal-title":"Brain Res."},{"key":"10.1016\/j.brainres.2017.12.028_b0085","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1097\/FBP.0b013e3282de7929","article-title":"The role of hippocampus in anxiety: intracerebral infusion studies","volume":"18","author":"Engin","year":"2007","journal-title":"Behav. Pharmacol."},{"key":"10.1016\/j.brainres.2017.12.028_b0090","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1111\/gbb.12133","article-title":"Abnormal vibrissa-related behavior and loss of barrel field inhibitory neurons in 5xFAD transgenics","volume":"13","author":"Flanigan","year":"2014","journal-title":"Genes Brain Behav."},{"key":"10.1016\/j.brainres.2017.12.028_b0095","doi-asserted-by":"crossref","first-page":"1934","DOI":"10.1038\/npp.2012.40","article-title":"Reduced tissue levels of noradrenaline are associated with behavioral phenotypes of the TgCRND8 mouse model of Alzheimer's disease","volume":"37","author":"Francis","year":"2012","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.brainres.2017.12.028_b0100","doi-asserted-by":"crossref","first-page":"1776","DOI":"10.1523\/JNEUROSCI.08-05-01776.1988","article-title":"The human locus coeruleus: computer reconstruction of cellular distribution","volume":"8","author":"German","year":"1988","journal-title":"J. Neurosci."},{"key":"10.1016\/j.brainres.2017.12.028_b0105","doi-asserted-by":"crossref","first-page":"96","DOI":"10.3389\/fnagi.2013.00096","article-title":"Early administration of RS 67333, a specific 5-HT4 receptor agonist, prevents amyloidogenesis and behavioral deficits in the 5XFAD mouse model of Alzheimer's disease","volume":"5","author":"Giannoni","year":"2013","journal-title":"Front. Aging Neurosci."},{"key":"10.1016\/j.brainres.2017.12.028_b0110","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/0197-4580(81)90056-7","article-title":"Neuron numbers in locus coeruleus do not change with age in Fisher 344 rat","volume":"2","author":"Goldman","year":"1981","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.brainres.2017.12.028_b0115","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1007\/s002130050038","article-title":"Differences in anxiety-related behaviours and in sensitivity to diazepam in inbred and outbred strains of mice","volume":"148","author":"Griebel","year":"2000","journal-title":"Psychopharmacology"},{"key":"10.1016\/j.brainres.2017.12.028_b0120","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1016\/j.neurobiolaging.2006.02.007","article-title":"Locus coeruleus neurofibrillary degeneration in aging, mild cognitive impairment and early Alzheimer's disease","volume":"28","author":"Grudzien","year":"2007","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.brainres.2017.12.028_b0125","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1016\/j.neurobiolaging.2007.05.020","article-title":"Early locus coeruleus degeneration and olfactory dysfunctions in Tg2576 mice","volume":"30","author":"Guerin","year":"2009","journal-title":"Neurobiol. Aging."},{"key":"10.1016\/j.brainres.2017.12.028_b0130","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1016\/j.biopsych.2012.06.013","article-title":"Selective loss of noradrenaline exacerbates early cognitive dysfunction and synaptic deficits in APP\/PS1 mice","volume":"73","author":"Hammerschmidt","year":"2013","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.brainres.2017.12.028_b0135","article-title":"Limited Effects of Prolonged Environmental Enrichment on the Pathology of 5XFAD Mice","author":"Huttenrauch","year":"2016","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.brainres.2017.12.028_b0140","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1111\/j.1365-2826.2010.01988.x","article-title":"The brainstem noradrenergic systems in stress, anxiety and depression","volume":"22","author":"Itoi","year":"2010","journal-title":"J. Neuroendocrinol."},{"key":"10.1016\/j.brainres.2017.12.028_b0145","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/0304-3940(83)90171-4","article-title":"Loss of pigmented dopamine-beta-hydroxylase positive cells from locus coeruleus in senile dementia of Alzheimer's type","volume":"39","author":"Iversen","year":"1983","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.brainres.2017.12.028_b0150","doi-asserted-by":"crossref","unstructured":"D. Jardanhazi-Kurutz, et al., 2010. Induced LC degeneration in APP\/PS1 transgenic mice accelerates early cerebral amyloidosis and cognitive deficits. Neurochem. Int.","DOI":"10.1016\/j.neuint.2010.02.001"},{"key":"10.1016\/j.brainres.2017.12.028_b0155","doi-asserted-by":"crossref","unstructured":"Jawhar, S., et al., 2012. Motor deficits, neuron loss, and reduced anxiety coinciding with axonal degeneration and intraneuronal Abeta aggregation in the 5XFAD mouse model of Alzheimer's disease. Neurobiol. Aging 33, 196.e29\u2013193.e40.","DOI":"10.1016\/j.neurobiolaging.2010.05.027"},{"key":"10.1016\/j.brainres.2017.12.028_b0160","unstructured":"Kalinin, S., et al., 2006a. Noradrenaline deficiency in brain increases beta-amyloid plaque burden in an animal model of Alzheimer's disease. Neurobiol. Aging."},{"key":"10.1016\/j.brainres.2017.12.028_b0165","doi-asserted-by":"crossref","first-page":"873","DOI":"10.1089\/ars.2006.8.873","article-title":"Beta-amyloid-dependent expression of NOS2 in neurons: prevention by an alpha2-adrenergic antagonist","volume":"8","author":"Kalinin","year":"2006","journal-title":"Antioxid. Redox. Signal."},{"key":"10.1016\/j.brainres.2017.12.028_b0170","doi-asserted-by":"crossref","first-page":"1651","DOI":"10.1016\/j.neurobiolaging.2011.04.012","article-title":"The noradrenaline precursor L-DOPS reduces pathology in a mouse model of Alzheimer's disease","volume":"33","author":"Kalinin","year":"2012","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.brainres.2017.12.028_b0175","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/0014-2999(92)90261-2","article-title":"Elevated basal firing rates and enhanced responses to 8-Br-cAMP in locus coeruleus neurons in brain slices from opiate-dependent rats","volume":"211","author":"Kogan","year":"1992","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.brainres.2017.12.028_b0180","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/j.jphs.2016.06.005","article-title":"Ameliorative effect of membrane-associated estrogen receptor G protein coupled receptor 30 activation on object recognition memory in mouse models of Alzheimer's disease","volume":"131","author":"Kubota","year":"2016","journal-title":"J. Pharmacol. Sci."},{"key":"10.1016\/j.brainres.2017.12.028_b0185","doi-asserted-by":"crossref","first-page":"8845","DOI":"10.1523\/JNEUROSCI.4027-13.2014","article-title":"Ear2 deletion causes early memory and learning deficits in APP\/PS1 mice","volume":"34","author":"Kummer","year":"2014","journal-title":"J. Neurosci."},{"key":"10.1016\/j.brainres.2017.12.028_b0190","doi-asserted-by":"crossref","first-page":"1367","DOI":"10.1111\/j.1471-4159.1988.tb01099.x","article-title":"Long-term effects of RU24722 on tyrosine hydroxylase of the rat brain","volume":"51","author":"Labatut","year":"1988","journal-title":"J. Neurochem."},{"key":"10.1016\/j.brainres.2017.12.028_b0195","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/S0006-8993(03)02694-5","article-title":"Transgenic mice expressing the betaAPP695SWE mutation: effects on exploratory activity, anxiety, and motor coordination","volume":"977","author":"Lalonde","year":"2003","journal-title":"Brain Res."},{"key":"10.1016\/j.brainres.2017.12.028_b0200","doi-asserted-by":"crossref","first-page":"2531","DOI":"10.1038\/nprot.2013.155","article-title":"Object recognition test in mice","volume":"8","author":"Leger","year":"2013","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.brainres.2017.12.028_b0205","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1016\/0306-4522(86)90156-9","article-title":"Efferent projections of nucleus locus coeruleus: morphologic subpopulations have different efferent targets","volume":"18","author":"Loughlin","year":"1986","journal-title":"Neuroscience"},{"key":"10.1016\/j.brainres.2017.12.028_b0210","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/S0304-3940(98)00028-7","article-title":"Plasticity of tyrosine hydroxylase gene expression within BALB\/C and C57Black\/6 mouse locus coeruleus","volume":"242","author":"Marcel","year":"1998","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.brainres.2017.12.028_b0215","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/j.brainresrev.2004.02.002","article-title":"Noradrenergic mechanisms in neurodegenerative diseases: a theory","volume":"45","author":"Marien","year":"2004","journal-title":"Brain Res. Brain Res. Rev."},{"key":"10.1016\/j.brainres.2017.12.028_b0220","doi-asserted-by":"crossref","unstructured":"McCall, J.G., et al., 2017. Locus coeruleus to basolateral amygdala noradrenergic projections promote anxiety-like behavior. Elife. 6.","DOI":"10.7554\/eLife.18247"},{"key":"10.1016\/j.brainres.2017.12.028_b0225","doi-asserted-by":"crossref","first-page":"21","DOI":"10.3389\/fnins.2011.00021","article-title":"Therapeutic utility of phosphodiesterase type I inhibitors in neurological conditions","volume":"5","author":"Medina","year":"2011","journal-title":"Front. Neurosci."},{"key":"10.1016\/j.brainres.2017.12.028_b0230","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1111\/j.1471-4159.1992.tb09748.x","article-title":"Coordinate regulation of the cyclic AMP system with firing rate and expression of tyrosine hydroxylase in the rat locus coeruleus: effects of chronic stress and drug treatments","volume":"58","author":"Melia","year":"1992","journal-title":"J. Neurochem."},{"key":"10.1016\/j.brainres.2017.12.028_b0235","doi-asserted-by":"crossref","first-page":"1131","DOI":"10.1016\/S0006-3223(99)00158-4","article-title":"Molecular control of locus coeruleus neurotransmission","volume":"46","author":"Nestler","year":"1999","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.brainres.2017.12.028_b0240","doi-asserted-by":"crossref","first-page":"10129","DOI":"10.1523\/JNEUROSCI.1202-06.2006","article-title":"Intraneuronal beta-amyloid aggregates, neurodegeneration, and neuron loss in transgenic mice with five familial Alzheimer's disease mutations: potential factors in amyloid plaque formation","volume":"26","author":"Oakley","year":"2006","journal-title":"J. Neurosci."},{"key":"10.1016\/j.brainres.2017.12.028_b0245","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1016\/j.nbd.2006.12.008","article-title":"BACE1 gene deletion prevents neuron loss and memory deficits in 5XFAD APP\/PS1 transgenic mice","volume":"26","author":"Ohno","year":"2007","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.brainres.2017.12.028_b0250","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1093\/brain\/awq362","article-title":"Locus coeruleus damage and noradrenaline reductions in multiple sclerosis and experimental autoimmune encephalomyelitis","volume":"134","author":"Polak","year":"2011","journal-title":"Brain"},{"key":"10.1016\/j.brainres.2017.12.028_b0255","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1111\/j.1471-4159.2012.07673.x","article-title":"The vincamine derivative vindeburnol provides benefit in a mouse model of multiple sclerosis: effects on the Locus coeruleus","volume":"121","author":"Polak","year":"2012","journal-title":"J. Neurochem."},{"key":"10.1016\/j.brainres.2017.12.028_b0260","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/j.jneuroim.2014.09.004","article-title":"The blood-brain barrier-permeable catechol-O-methyltransferase inhibitor dinitrocatechol suppresses experimental autoimmune encephalomyelitis","volume":"276","author":"Polak","year":"2014","journal-title":"J. Neuroimmunol."},{"key":"10.1016\/j.brainres.2017.12.028_b0265","doi-asserted-by":"crossref","first-page":"58","DOI":"10.3389\/fnbeh.2015.00058","article-title":"Impact of an additional chronic BDNF reduction on learning performance in an Alzheimer mouse model","volume":"9","author":"Psotta","year":"2015","journal-title":"Front. Behav. Neurosci."},{"key":"10.1016\/j.brainres.2017.12.028_b0270","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1016\/j.neurobiolaging.2010.10.009","article-title":"Locus coeruleus degeneration exacerbates olfactory deficits in APP\/PS1 transgenic mice","volume":"33","author":"Rey","year":"2012","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.brainres.2017.12.028_b0275","doi-asserted-by":"crossref","first-page":"1223","DOI":"10.3233\/JAD-143120","article-title":"Gene dosage dependent aggravation of the neurological phenotype in the 5XFAD mouse model of Alzheimer's disease","volume":"45","author":"Richard","year":"2015","journal-title":"J. Alzheimers Dis."},{"key":"10.1016\/j.brainres.2017.12.028_b0280","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/j.pbb.2014.11.006","article-title":"Effects of methylphenidate on the behavior of male 5xFAD mice","volume":"128","author":"Schneider","year":"2015","journal-title":"Pharmacol. Biochem. Behav."},{"key":"10.1016\/j.brainres.2017.12.028_b0285","article-title":"Monoaminergic neuropathology in Alzheimer's disease","author":"Simic","year":"2016","journal-title":"Prog. Neurobiol."},{"key":"10.1016\/j.brainres.2017.12.028_b0290","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1007\/s11481-009-9182-2","article-title":"Increasing CNS noradrenaline reduces EAE severity","volume":"5","author":"Simonini","year":"2010","journal-title":"J. Neuroimmune. Pharmacol."},{"key":"10.1016\/j.brainres.2017.12.028_b0295","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/0006-8993(93)91043-R","article-title":"Neurotrophic effects of cAMP generating systems on central noradrenergic neurons","volume":"614","author":"Sklair-Tavron","year":"1993","journal-title":"Brain Res"},{"key":"10.1016\/j.brainres.2017.12.028_b0300","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1016\/S0079-6123(08)63838-8","article-title":"Regulation of the development of locus coeruleus neurons in vitro","volume":"88","author":"Sklair","year":"1991","journal-title":"Prog. Brain Res."},{"key":"10.1016\/j.brainres.2017.12.028_b0305","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1002\/bem.21992","article-title":"1950 MHz radiofrequency electromagnetic fields do not aggravate memory deficits in 5xFAD mice","volume":"37","author":"Son","year":"2016","journal-title":"Bioelectromagnetics"},{"key":"10.1016\/j.brainres.2017.12.028_b0310","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1111\/j.1365-2990.1985.tb00004.x","article-title":"A quantitative histological study of neuronal loss from the locus coeruleus of ageing mice","volume":"11","author":"Sturrock","year":"1985","journal-title":"Neuropathol. Appl. Neurobiol."},{"key":"10.1016\/j.brainres.2017.12.028_b0315","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1016\/0014-2999(84)90723-4","article-title":"Effect of a new eburnamine derivative, RU 24722, on the turnover of monoamines in mouse brain: selective and reversible decrease of noradrenaline","volume":"106","author":"Takeda","year":"1984","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.brainres.2017.12.028_b0320","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1016\/S0014-2999(00)00569-0","article-title":"Noradrenaline systems in the hypothalamus, amygdala and locus coeruleus are involved in the provocation of anxiety: basic studies","volume":"405","author":"Tanaka","year":"2000","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.brainres.2017.12.028_b0325","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1016\/S0896-6273(00)81010-7","article-title":"Ca2+ influx regulates BDNF transcription by a CREB family transcription factor-dependent mechanism","volume":"20","author":"Tao","year":"1998","journal-title":"Neuron"},{"key":"10.1016\/j.brainres.2017.12.028_b0330","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1002\/med.20043","article-title":"Eburnamine derivatives and the brain","volume":"25","author":"Vas","year":"2005","journal-title":"Med. Res. Rev."},{"key":"10.1016\/j.brainres.2017.12.028_b0335","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1159\/000477092","article-title":"Deletion of the inflammasome sensor Aim2 mitigates abeta deposition and microglial activation but increases inflammatory cytokine expression in an Alzheimer disease mouse model","volume":"24","author":"Wu","year":"2017","journal-title":"Neuroimmunomodulation"},{"key":"10.1016\/j.brainres.2017.12.028_b0340","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1007\/s00702-006-0548-9","article-title":"Levels of neurotrophic factors in the hippocampus and amygdala correlate with anxiety- and fear-related behaviour in C57BL6 mice","volume":"114","author":"Yee","year":"2007","journal-title":"J. Neural Transm. (Vienna)"},{"key":"10.1016\/j.brainres.2017.12.028_b0345","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1111\/j.1471-4159.1990.tb04569.x","article-title":"Ontogeny of tyrosine hydroxylase concentration in locus coeruleus of newborn rats: long-term effects of RU24722","volume":"55","author":"Zyzek","year":"1990","journal-title":"J. Neurochem."}],"container-title":["Brain Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006899317305632?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006899317305632?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,12,1]],"date-time":"2018-12-01T04:36:46Z","timestamp":1543639006000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006899317305632"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,1]]},"references-count":69,"alternative-id":["S0006899317305632"],"URL":"https:\/\/doi.org\/10.1016\/j.brainres.2017.12.028","relation":{},"ISSN":["0006-8993"],"issn-type":[{"value":"0006-8993","type":"print"}],"subject":[],"published":{"date-parts":[[2019,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The locus coeruleus neuroprotective drug vindeburnol normalizes behavior in the 5xFAD transgenic mouse model of Alzheimer\u2019s disease","name":"articletitle","label":"Article Title"},{"value":"Brain Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.brainres.2017.12.028","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Published by Elsevier B.V.","name":"copyright","label":"Copyright"}]}}