{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T19:36:11Z","timestamp":1790537771971,"version":"4.1.0"},"reference-count":302,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2018,8,1]],"date-time":"2018-08-01T00:00:00Z","timestamp":1533081600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,8,1]],"date-time":"2018-08-01T00:00:00Z","timestamp":1533081600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2019,6,13]],"date-time":"2019-06-13T00:00:00Z","timestamp":1560384000000},"content-version":"am","delay-in-days":316,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000971","name":"ALS Association","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000971","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Brain Research"],"published-print":{"date-parts":[[2018,8]]},"DOI":"10.1016\/j.brainres.2018.02.018","type":"journal-article","created":{"date-parts":[[2018,2,17]],"date-time":"2018-02-17T12:25:54Z","timestamp":1518870354000},"page":"75-91","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":66,"special_numbering":"PA","title":["mRNP assembly, axonal transport, and local translation in neurodegenerative diseases"],"prefix":"10.1016","volume":"1693","author":[{"given":"Bilal","family":"Khalil","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3413-1597","authenticated-orcid":false,"given":"Dmytro","family":"Morderer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Phillip L.","family":"Price","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feilin","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9622-541X","authenticated-orcid":false,"given":"Wilfried","family":"Rossoll","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.brainres.2018.02.018_b0005","doi-asserted-by":"crossref","first-page":"10337","DOI":"10.1073\/pnas.1104928108","article-title":"Interaction of survival of motor neuron (SMN) and HuD proteins with mRNA cpg15 rescues motor neuron axonal deficits","volume":"108","author":"Akten","year":"2011","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.brainres.2018.02.018_b0010","doi-asserted-by":"crossref","first-page":"536","DOI":"10.1016\/j.neuron.2013.12.018","article-title":"Axonal transport of TDP-43 mRNA granules is impaired by ALS-causing mutations","volume":"81","author":"Alami","year":"2014","journal-title":"Neuron"},{"key":"10.1016\/j.brainres.2018.02.018_b0015","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1002\/ana.21154","article-title":"TDP-43 immunoreactivity in hippocampal sclerosis and Alzheimer's disease","volume":"61","author":"Amador-Ortiz","year":"2007","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.brainres.2018.02.018_b0020","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1038\/nn.2486","article-title":"An NGF-responsive element targets myo-inositol monophosphatase-1 mRNA to sympathetic neuron axons","volume":"13","author":"Andreassi","year":"2010","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.brainres.2018.02.018_b0025","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1111\/j.1601-183X.2005.00128.x","article-title":"Localization of FMRP-associated mRNA granules and requirement of microtubules for activity-dependent trafficking in hippocampal neurons","volume":"4","author":"Antar","year":"2005","journal-title":"Genes Brain Behav."},{"key":"10.1016\/j.brainres.2018.02.018_b0030","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.mcn.2006.02.001","article-title":"Local functions for FMRP in axon growth cone motility and activity-dependent regulation of filopodia and spine synapses","volume":"32","author":"Antar","year":"2006","journal-title":"Mol. Cell. Neurosci."},{"key":"10.1016\/j.brainres.2018.02.018_b0035","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1007\/s00401-008-0480-1","article-title":"Phosphorylated TDP-43 in Alzheimer's disease and dementia with Lewy bodies","volume":"117","author":"Arai","year":"2009","journal-title":"Acta Neuropathol."},{"key":"10.1016\/j.brainres.2018.02.018_b0040","doi-asserted-by":"crossref","DOI":"10.1523\/ENEURO.0385-16.2017","article-title":"Disruption of the axonal trafficking of tyrosine hydroxylase mRNA impairs catecholamine biosynthesis in the axons of sympathetic neurons","volume":"4","author":"Aschrafi","year":"2017","journal-title":"eNeuro"},{"key":"10.1016\/j.brainres.2018.02.018_b0045","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1016\/j.neuron.2013.02.004","article-title":"Unconventional translation of C9ORF72 GGGGCC expansion generates insoluble polypeptides specific to c9FTD\/ALS","volume":"77","author":"Ash","year":"2013","journal-title":"Neuron"},{"key":"10.1016\/j.brainres.2018.02.018_b0050","doi-asserted-by":"crossref","first-page":"23204","DOI":"10.1038\/srep23204","article-title":"C9orf72 ablation causes immune dysregulation characterized by leukocyte expansion, autoantibody production, and glomerulonephropathy in mice","volume":"6","author":"Atanasio","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.brainres.2018.02.018_b0055","doi-asserted-by":"crossref","first-page":"2615","DOI":"10.1021\/bi00847a025","article-title":"Biochemical studies of synapses in vitro I. Protein synthesis","volume":"7","author":"Autilio","year":"1968","journal-title":"Biochemistry"},{"key":"10.1016\/j.brainres.2018.02.018_b0060","doi-asserted-by":"crossref","first-page":"1159","DOI":"10.1016\/j.cell.2014.07.001","article-title":"Axonally synthesized ATF4 transmits a neurodegenerative signal across brain regions","volume":"158","author":"Baleriola","year":"2014","journal-title":"Cell"},{"key":"10.1016\/j.brainres.2018.02.018_b0065","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1007\/s13311-014-0308-8","article-title":"Targeting axonal protein synthesis in neuroregeneration and degeneration","volume":"12","author":"Baleriola","year":"2015","journal-title":"Neurotherapeutics"},{"key":"10.1016\/j.brainres.2018.02.018_b0070","doi-asserted-by":"crossref","first-page":"e1000773","DOI":"10.1371\/journal.pgen.1000773","article-title":"Alternative splicing events are a late feature of pathology in a mouse model of spinal muscular atrophy","volume":"5","author":"Baumer","year":"2009","journal-title":"PLoS Genet."},{"key":"10.1016\/j.brainres.2018.02.018_b0075","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1016\/j.neulet.2004.12.071","article-title":"Delocalization of the multifunctional RNA splicing factor TLS\/FUS in hippocampal neurones: exclusion from the nucleus and accumulation in dendritic granules and spine heads","volume":"379","author":"Belly","year":"2005","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.brainres.2018.02.018_b0080","doi-asserted-by":"crossref","first-page":"895","DOI":"10.1007\/s00401-013-1199-1","article-title":"Reduced C9orf72 gene expression in c9FTD\/ALS is caused by histone trimethylation, an epigenetic event detectable in blood","volume":"126","author":"Belzil","year":"2013","journal-title":"Acta Neuropathol."},{"key":"10.1016\/j.brainres.2018.02.018_b0085","doi-asserted-by":"crossref","first-page":"1350","DOI":"10.1038\/emboj.2011.494","article-title":"Axonal transcription factors signal retrogradely in lesioned peripheral nerve","volume":"31","author":"Ben-Yaakov","year":"2012","journal-title":"EMBO J."},{"key":"10.1016\/j.brainres.2018.02.018_b0090","doi-asserted-by":"crossref","first-page":"953","DOI":"10.1016\/j.celrep.2017.10.010","article-title":"In vivo translatome profiling in spinal muscular atrophy reveals a role for SMN protein in ribosome biology","volume":"21","author":"Bernabo","year":"2017","journal-title":"Cell Rep."},{"key":"10.1016\/j.brainres.2018.02.018_b0095","doi-asserted-by":"crossref","first-page":"13810","DOI":"10.1073\/pnas.0703805104","article-title":"Copb1-facilitated axonal transport and translation of kappa opioid-receptor mRNA","volume":"104","author":"Bi","year":"2007","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.brainres.2018.02.018_b0100","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1001\/jamaneurol.2013.5847","article-title":"Amyloid-beta and tau: the trigger and bullet in Alzheimer disease pathogenesis","volume":"71","author":"Bloom","year":"2014","journal-title":"JAMA Neurol."},{"key":"10.1016\/j.brainres.2018.02.018_b0105","doi-asserted-by":"crossref","first-page":"6","DOI":"10.3389\/fnana.2016.00006","article-title":"Neuromuscular junctions as key contributors and therapeutic targets in spinal muscular atrophy","volume":"10","author":"Boido","year":"2016","journal-title":"Front. Neuroanat."},{"key":"10.1016\/j.brainres.2018.02.018_b0110","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1016\/j.nbd.2017.04.010","article-title":"Regulation of motor proteins, axonal transport deficits and adult-onset neurodegenerative diseases","volume":"105","author":"Brady","year":"2017","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.brainres.2018.02.018_b0115","doi-asserted-by":"crossref","first-page":"1729","DOI":"10.1126\/science.1172046","article-title":"Germline P granules are liquid droplets that localize by controlled dissolution\/condensation","volume":"324","author":"Brangwynne","year":"2009","journal-title":"Science"},{"key":"10.1016\/j.brainres.2018.02.018_b0120","doi-asserted-by":"crossref","first-page":"946","DOI":"10.1002\/bies.20283","article-title":"Is spinal muscular atrophy the result of defects in motor neuron processes?","volume":"27","author":"Briese","year":"2005","journal-title":"Bioessays"},{"key":"10.1016\/j.brainres.2018.02.018_b0125","doi-asserted-by":"crossref","first-page":"e33","DOI":"10.1093\/nar\/gkv1027","article-title":"Whole transcriptome profiling reveals the RNA content of motor axons","volume":"44","author":"Briese","year":"2016","journal-title":"Nucl. Acids Res."},{"key":"10.1016\/j.brainres.2018.02.018_b0130","doi-asserted-by":"crossref","first-page":"1019","DOI":"10.1261\/rna.039164.113","article-title":"Emerging complexity of the HuD\/ELAVl4 gene; implications for neuronal development, function, and dysfunction","volume":"19","author":"Bronicki","year":"2013","journal-title":"RNA"},{"key":"10.1016\/j.brainres.2018.02.018_b0135","doi-asserted-by":"crossref","first-page":"1019","DOI":"10.4161\/15476286.2014.972208","article-title":"mRNP granules. Assembly, function, and connections with disease","volume":"11","author":"Buchan","year":"2014","journal-title":"RNA Biol."},{"key":"10.1016\/j.brainres.2018.02.018_b0140","doi-asserted-by":"crossref","first-page":"347ra93","DOI":"10.1126\/scitranslmed.aaf6038","article-title":"Loss-of-function mutations in the C9ORF72 mouse ortholog cause fatal autoimmune disease","volume":"8","author":"Burberry","year":"2016","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.brainres.2018.02.018_b0145","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1038\/nrn2670","article-title":"Spinal muscular atrophy: why do low levels of survival motor neuron protein make motor neurons sick?","volume":"10","author":"Burghes","year":"2009","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.brainres.2018.02.018_b0150","doi-asserted-by":"crossref","first-page":"e08881","DOI":"10.7554\/eLife.08881","article-title":"GGGGCC microsatellite RNA is neuritically localized, induces branching defects, and perturbs transport granule function","volume":"4","author":"Burguete","year":"2015","journal-title":"Elife"},{"key":"10.1016\/j.brainres.2018.02.018_b0155","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1016\/j.neuron.2012.02.036","article-title":"The local transcriptome in the synaptic neuropil revealed by deep sequencing and high-resolution imaging","volume":"74","author":"Cajigas","year":"2012","journal-title":"Neuron"},{"key":"10.1016\/j.brainres.2018.02.018_b0160","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1002\/dneu.22155","article-title":"Myosin Va associates with mRNA in ribonucleoprotein particles present in myelinated peripheral axons and in the central nervous system","volume":"74","author":"Calliari","year":"2014","journal-title":"Dev. Neurobiol."},{"key":"10.1016\/j.brainres.2018.02.018_b0165","doi-asserted-by":"crossref","first-page":"1013","DOI":"10.1016\/S0896-6273(01)00551-7","article-title":"Chemotropic responses of retinal growth cones mediated by rapid local protein synthesis and degradation","volume":"32","author":"Campbell","year":"2001","journal-title":"Neuron"},{"key":"10.1016\/j.brainres.2018.02.018_b0170","doi-asserted-by":"crossref","first-page":"11014","DOI":"10.1523\/JNEUROSCI.1637-06.2006","article-title":"Survival motor neuron function in motor axons is independent of functions required for small nuclear ribonucleoprotein biogenesis","volume":"26","author":"Carrel","year":"2006","journal-title":"J. Neurosci."},{"key":"10.1016\/j.brainres.2018.02.018_b0175","doi-asserted-by":"crossref","first-page":"1393","DOI":"10.1016\/j.cell.2012.04.031","article-title":"Insights into RNA biology from an atlas of mammalian mRNA-binding proteins","volume":"149","author":"Castello","year":"2012","journal-title":"Cell"},{"key":"10.1016\/j.brainres.2018.02.018_b0180","doi-asserted-by":"crossref","first-page":"696","DOI":"10.1016\/j.molcel.2016.06.029","article-title":"Comprehensive Identification of RNA-Binding Domains in Human Cells","volume":"63","author":"Castello","year":"2016","journal-title":"Mol. Cell."},{"key":"10.1016\/j.brainres.2018.02.018_b0185","doi-asserted-by":"crossref","first-page":"1094","DOI":"10.1016\/j.bbadis.2006.04.002","article-title":"Axonal transport and neurodegenerative disease","volume":"1762","author":"Chevalier-Larsen","year":"2006","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.brainres.2018.02.018_b0190","doi-asserted-by":"crossref","first-page":"139","DOI":"10.3389\/fnagi.2014.00139","article-title":"Axonal degeneration in an Alzheimer mouse model is PS1 gene dose dependent and linked to intraneuronal Abeta accumulation","volume":"6","author":"Christensen","year":"2014","journal-title":"Front. Aging Neurosci."},{"issue":"242\u2013250","key":"10.1016\/j.brainres.2018.02.018_b0195","first-page":"e4","article-title":"In situ peroxidase labeling and mass-spectrometry connects alpha-synuclein directly to endocytic trafficking and mRNA metabolism in neurons","volume":"4","author":"Chung","year":"2017","journal-title":"Cell Syst."},{"key":"10.1016\/j.brainres.2018.02.018_b0200","doi-asserted-by":"crossref","first-page":"1252","DOI":"10.1016\/j.cell.2013.04.056","article-title":"Regulation of axon guidance by compartmentalized nonsense-mediated mRNA decay","volume":"153","author":"Colak","year":"2013","journal-title":"Cell"},{"key":"10.1016\/j.brainres.2018.02.018_b0205","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1111\/tra.12472","article-title":"Global and local mechanisms sustain axonal proteostasis of transmembrane proteins","volume":"18","author":"Cornejo","year":"2017","journal-title":"Traffic"},{"key":"10.1016\/j.brainres.2018.02.018_b0210","doi-asserted-by":"crossref","first-page":"5195","DOI":"10.1523\/JNEUROSCI.3862-12.2013","article-title":"Target-derived neurotrophins coordinate transcription and transport of bclw to prevent axonal degeneration","volume":"33","author":"Cosker","year":"2013","journal-title":"J. Neurosci."},{"key":"10.1016\/j.brainres.2018.02.018_b0215","article-title":"To the end of the line: Axonal mRNA transport and local translation in health and neurodegenerative disease","author":"Costa","year":"2017","journal-title":"Dev. Neurobilo."},{"key":"10.1016\/j.brainres.2018.02.018_b0220","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1038\/ncb1677","article-title":"Intra-axonal translation and retrograde trafficking of CREB promotes neuronal survival","volume":"10","author":"Cox","year":"2008","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.brainres.2018.02.018_b0225","doi-asserted-by":"crossref","first-page":"15962","DOI":"10.1523\/JNEUROSCI.2526-14.2014","article-title":"Futsch\/MAP1B mRNA Is a translational target of TDP-43 and Is neuroprotective in a drosophila model of amyotrophic lateral sclerosis","volume":"34","author":"Coyne","year":"2014","journal-title":"J. Neurosci."},{"key":"10.1016\/j.brainres.2018.02.018_b0230","doi-asserted-by":"crossref","first-page":"243","DOI":"10.3389\/fncel.2017.00243","article-title":"Failure to deliver and translate-new insights into RNA dysregulation in ALS","volume":"11","author":"Coyne","year":"2017","journal-title":"Front. Cell Neurosci."},{"key":"10.1016\/j.brainres.2018.02.018_b0235","doi-asserted-by":"crossref","first-page":"e0163954","DOI":"10.1371\/journal.pone.0163954","article-title":"Altered mRNA Splicing in SMN-Depleted Motor Neuron-Like Cells","volume":"11","author":"Custer","year":"2016","journal-title":"PLoS One"},{"key":"10.1016\/j.brainres.2018.02.018_b0240","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1016\/j.neuron.2011.11.033","article-title":"Propagation of tau pathology in a model of early Alzheimer's disease","volume":"73","author":"de Calignon","year":"2012","journal-title":"Neuron"},{"key":"10.1016\/j.brainres.2018.02.018_b0245","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1016\/j.nbd.2017.02.004","article-title":"Neurobiology of axonal transport defects in motor neuron diseases: Opportunities for translational research?","volume":"105","author":"De Vos","year":"2017","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.brainres.2018.02.018_b0250","doi-asserted-by":"crossref","first-page":"6888","DOI":"10.1038\/ncomms7888","article-title":"Coupled local translation and degradation regulate growth cone collapse","volume":"6","author":"Deglincerti","year":"2015","journal-title":"Nat. Commun."},{"key":"10.1016\/j.brainres.2018.02.018_b0255","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/j.neuron.2011.09.011","article-title":"Expanded GGGGCC hexanucleotide repeat in noncoding region of C9ORF72 causes chromosome 9p-linked FTD and ALS","volume":"72","author":"DeJesus-Hernandez","year":"2011","journal-title":"Neuron"},{"key":"10.1016\/j.brainres.2018.02.018_b0260","doi-asserted-by":"crossref","first-page":"35296","DOI":"10.1074\/jbc.M114.562959","article-title":"Aggregation properties of the small nuclear ribonucleoprotein U1\u201370K in Alzheimer disease","volume":"289","author":"Diner","year":"2014","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.brainres.2018.02.018_b0265","doi-asserted-by":"crossref","first-page":"6489","DOI":"10.1074\/jbc.M705306200","article-title":"RNA-binding protein TLS is a major nuclear aggregate-interacting protein in huntingtin exon 1 with expanded polyglutamine-expressing cells","volume":"283","author":"Doi","year":"2008","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.brainres.2018.02.018_b0270","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1093\/nar\/gkw731","article-title":"RNA-sequencing of a mouse-model of spinal muscular atrophy reveals tissue-wide changes in splicing of U12-dependent introns","volume":"45","author":"Doktor","year":"2017","journal-title":"Nucl. Acids Res."},{"key":"10.1016\/j.brainres.2018.02.018_b0275","doi-asserted-by":"crossref","first-page":"e110846","DOI":"10.1371\/journal.pone.0110846","article-title":"Presynaptic localization of Smn and hnRNP R in axon terminals of embryonic and postnatal mouse motoneurons","volume":"9","author":"Dombert","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.brainres.2018.02.018_b0280","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.conb.2016.04.004","article-title":"A role for the survival of motor neuron protein in mRNP assembly and transport","volume":"39","author":"Donlin-Asp","year":"2016","journal-title":"Curr. Opin. Neurobiol."},{"key":"10.1016\/j.brainres.2018.02.018_b0285","doi-asserted-by":"crossref","first-page":"1660","DOI":"10.1016\/j.celrep.2017.01.059","article-title":"The survival of motor neuron protein acts as a molecular chaperone for mRNP assembly","volume":"18","author":"Donlin-Asp","year":"2017","journal-title":"Cell Rep."},{"key":"10.1016\/j.brainres.2018.02.018_b0290","doi-asserted-by":"crossref","first-page":"4665","DOI":"10.1038\/emboj.2011.347","article-title":"Limited availability of ZBP1 restricts axonal mRNA localization and nerve regeneration capacity","volume":"30","author":"Donnelly","year":"2011","journal-title":"EMBO J."},{"key":"10.1016\/j.brainres.2018.02.018_b0295","doi-asserted-by":"crossref","first-page":"3311","DOI":"10.1523\/JNEUROSCI.1722-12.2013","article-title":"Axonally synthesized beta-actin and GAP-43 proteins support distinct modes of axonal growth","volume":"33","author":"Donnelly","year":"2013","journal-title":"J. Neurosci."},{"key":"10.1016\/j.brainres.2018.02.018_b0300","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1016\/j.neuron.2013.10.015","article-title":"RNA toxicity from the ALS\/FTD C9ORF72 expansion is mitigated by antisense intervention","volume":"80","author":"Donnelly","year":"2013","journal-title":"Neuron"},{"key":"10.1016\/j.brainres.2018.02.018_b0305","doi-asserted-by":"crossref","first-page":"2841","DOI":"10.1038\/emboj.2010.143","article-title":"ALS-associated fused in sarcoma (FUS) mutations disrupt transportin-mediated nuclear import","volume":"29","author":"Dormann","year":"2010","journal-title":"EMBO J."},{"key":"10.1016\/j.brainres.2018.02.018_b0310","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/j.conb.2015.10.009","article-title":"An amyloid-like cascade hypothesis for C9orf72 ALS\/FTD","volume":"36","author":"Edbauer","year":"2016","journal-title":"Curr. Opin. Neurobiol."},{"key":"10.1016\/j.brainres.2018.02.018_b0315","doi-asserted-by":"crossref","first-page":"1489","DOI":"10.1002\/1873-3468.12646","article-title":"TDP-43 and FUS en route from the nucleus to the cytoplasm","volume":"591","author":"Ederle","year":"2017","journal-title":"FEBS Lett."},{"key":"10.1016\/j.brainres.2018.02.018_b0320","doi-asserted-by":"crossref","first-page":"10433","DOI":"10.1523\/JNEUROSCI.23-32-10433.2003","article-title":"Localization of a beta-actin messenger ribonucleoprotein complex with zipcode-binding protein modulates the density of dendritic filopodia and filopodial synapses","volume":"23","author":"Eom","year":"2003","journal-title":"J. Neurosci."},{"key":"10.1016\/j.brainres.2018.02.018_b0325","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1186\/1750-1326-5-17","article-title":"High-efficiency transfection of cultured primary motor neurons to study protein localization, trafficking, and function","volume":"5","author":"Fallini","year":"2010","journal-title":"Mol. Neurodegener."},{"key":"10.1016\/j.brainres.2018.02.018_b0330","doi-asserted-by":"crossref","first-page":"3914","DOI":"10.1523\/JNEUROSCI.3631-10.2011","article-title":"The survival of motor neuron (SMN) protein interacts with the mRNA-binding protein HuD and regulates localization of poly(A) mRNA in primary motor neuron axons","volume":"31","author":"Fallini","year":"2011","journal-title":"J. Neurosci."},{"key":"10.1016\/j.brainres.2018.02.018_b0335","doi-asserted-by":"crossref","first-page":"3703","DOI":"10.1093\/hmg\/dds205","article-title":"The ALS disease protein TDP-43 is actively transported in motor neuron axons and regulates axon outgrowth","volume":"21","author":"Fallini","year":"2012","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.brainres.2018.02.018_b0340","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.brainres.2012.01.044","article-title":"Spinal muscular atrophy: the role of SMN in axonal mRNA regulation","volume":"1462","author":"Fallini","year":"2012","journal-title":"Brain Res."},{"key":"10.1016\/j.brainres.2018.02.018_b0345","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1002\/dneu.22111","article-title":"Dynamics of survival of motor neuron (SMN) protein interaction with the mRNA-binding protein IMP1 facilitates its trafficking into motor neuron axons","volume":"74","author":"Fallini","year":"2014","journal-title":"Dev. Neurobiol."},{"key":"10.1016\/j.brainres.2018.02.018_b0350","doi-asserted-by":"crossref","first-page":"3811","DOI":"10.1523\/JNEUROSCI.2396-15.2016","article-title":"Deficiency of the Survival of Motor Neuron Protein Impairs mRNA Localization and Local Translation in the Growth Cone of Motor Neurons","volume":"36","author":"Fallini","year":"2016","journal-title":"J. Neurosci."},{"key":"10.1016\/j.brainres.2018.02.018_b0355","doi-asserted-by":"crossref","first-page":"3579","DOI":"10.1093\/hmg\/ddu068","article-title":"C9ORF72, implicated in amytrophic lateral sclerosis and frontotemporal dementia, regulates endosomal trafficking","volume":"23","author":"Farg","year":"2014","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.brainres.2018.02.018_b0360","doi-asserted-by":"crossref","first-page":"E2955","DOI":"10.1073\/pnas.1616363114","article-title":"BORC\/kinesin-1 ensemble drives polarized transport of lysosomes into the axon","volume":"114","author":"Far\u00edas","year":"2017","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1016\/j.brainres.2018.02.018_b0365","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1002\/ana.24864","article-title":"Emerging therapies and challenges in spinal muscular atrophy","volume":"81","author":"Farrar","year":"2017","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.brainres.2018.02.018_b0370","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1016\/j.expneurol.2003.10.004","article-title":"Amyotrophic lateral sclerosis is a distal axonopathy: evidence in mice and man","volume":"185","author":"Fischer","year":"2004","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.brainres.2018.02.018_b0375","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1159\/000107704","article-title":"Axonal degeneration in motor neuron disease","volume":"4","author":"Fischer","year":"2007","journal-title":"Neurodegener. Dis."},{"key":"10.1016\/j.brainres.2018.02.018_b0380","doi-asserted-by":"crossref","first-page":"1104","DOI":"10.1021\/pr901076y","article-title":"Global analysis of TDP-43 interacting proteins reveals strong association with RNA splicing and translation machinery","volume":"9","author":"Freibaum","year":"2010","journal-title":"J. Prot. Res."},{"key":"10.1016\/j.brainres.2018.02.018_b0385","doi-asserted-by":"crossref","first-page":"35","DOI":"10.3389\/fnmol.2017.00035","article-title":"The role of dipeptide repeats in C9ORF72-related ALS-FTD","volume":"10","author":"Freibaum","year":"2017","journal-title":"Front. Mol. Neurosci."},{"key":"10.1016\/j.brainres.2018.02.018_b0390","doi-asserted-by":"crossref","first-page":"1443","DOI":"10.1083\/jcb.149.7.1443","article-title":"Shared and unique roles of CAP23 and GAP43 in actin regulation, neurite outgrowth, and anatomical plasticity","volume":"149","author":"Frey","year":"2000","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.brainres.2018.02.018_b0395","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1016\/j.cub.2005.01.058","article-title":"The RNA binding protein TLS is translocated to dendritic spines by mGluR5 activation and regulates spine morphology","volume":"15","author":"Fujii","year":"2005","journal-title":"Curr. Biol."},{"key":"10.1016\/j.brainres.2018.02.018_b0400","doi-asserted-by":"crossref","first-page":"5755","DOI":"10.1242\/jcs.02692","article-title":"TLS facilitates transport of mRNA encoding an actin-stabilizing protein to dendritic spines","volume":"118","author":"Fujii","year":"2005","journal-title":"J. Cell Sci."},{"key":"10.1016\/j.brainres.2018.02.018_b0405","doi-asserted-by":"crossref","first-page":"1215","DOI":"10.1261\/rna.057208.116","article-title":"Transcriptomic comparison of Drosophila snRNP biogenesis mutants reveals mutant-specific changes in pre-mRNA processing: implications for spinal muscular atrophy","volume":"22","author":"Garcia","year":"2016","journal-title":"RNA"},{"key":"10.1016\/j.brainres.2018.02.018_b0410","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1074\/mcp.M115.049965","article-title":"Proteomic analysis of dynein-interacting proteins in amyotrophic lateral sclerosis synaptosomes reveals alterations in the RNA-binding protein staufen1","volume":"15","author":"Gershoni-Emek","year":"2016","journal-title":"Mol. Cell Proteom."},{"key":"10.1016\/j.brainres.2018.02.018_b0415","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.brainres.2016.04.004","article-title":"There has been an awakening: emerging mechanisms of C9orf72 mutations in FTD\/ALS","volume":"1647","author":"Gitler","year":"2016","journal-title":"Brain Res."},{"key":"10.1016\/j.brainres.2018.02.018_b0420","doi-asserted-by":"crossref","first-page":"1951","DOI":"10.1093\/hmg\/ddq073","article-title":"The heterogeneous nuclear ribonucleoprotein-R is necessary for axonal beta-actin mRNA translocation in spinal motor neurons","volume":"19","author":"Glinka","year":"2010","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.brainres.2018.02.018_b0425","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/j.conb.2017.05.005","article-title":"mRNA transport & local translation in neurons","volume":"45","author":"Glock","year":"2017","journal-title":"Cur.r Opin. Neurobiol."},{"key":"10.1016\/j.brainres.2018.02.018_b0430","doi-asserted-by":"crossref","first-page":"e17808","DOI":"10.1371\/journal.pone.0017808","article-title":"TDP-43 regulates Drosophila neuromuscular junctions growth by modulating Futsch\/MAP1B levels and synaptic microtubules organization","volume":"6","author":"Godena","year":"2011","journal-title":"PLoS One"},{"key":"10.1016\/j.brainres.2018.02.018_b0435","doi-asserted-by":"crossref","first-page":"6999","DOI":"10.1073\/pnas.111145298","article-title":"Kinesin molecular motors: transport pathways, receptors, and human disease","volume":"98","author":"Goldstein","year":"2001","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.brainres.2018.02.018_b0440","doi-asserted-by":"crossref","DOI":"10.1242\/jcs.201244","article-title":"Axonal localization of neuritin\/CPG15 mRNA is limited by competition for HuD binding","author":"Gomes","year":"2017","journal-title":"J. Cell Sci."},{"key":"10.1016\/j.brainres.2018.02.018_b0445","doi-asserted-by":"crossref","first-page":"1823","DOI":"10.1073\/pnas.1514943113","article-title":"Axons provide the secretory machinery for trafficking of voltage-gated sodium channels in peripheral nerve","volume":"113","author":"Gonzalez","year":"2016","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.brainres.2018.02.018_b0450","doi-asserted-by":"crossref","first-page":"E2466","DOI":"10.1073\/pnas.1614462114","article-title":"Amyotrophic lateral sclerosis-linked mutations increase the viscosity of liquid-like TDP-43 RNP granules in neurons","volume":"114","author":"Gopal","year":"2017","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.brainres.2018.02.018_b0455","doi-asserted-by":"crossref","first-page":"3506","DOI":"10.1038\/ncomms4506","article-title":"Local translation of TC10 is required for membrane expansion during axon outgrowth","volume":"5","author":"Gracias","year":"2014","journal-title":"Nat. Commun."},{"key":"10.1016\/j.brainres.2018.02.018_b0460","doi-asserted-by":"crossref","first-page":"3690","DOI":"10.1093\/hmg\/ddt222","article-title":"ALS-associated mutations in FUS disrupt the axonal distribution and function of SMN","volume":"22","author":"Groen","year":"2013","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.brainres.2018.02.018_b0465","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1261\/rna.2386111","article-title":"Transcriptome analysis of embryonic and adult sensory axons reveals changes in mRNA repertoire localization","volume":"17","author":"Gumy","year":"2011","journal-title":"RNA"},{"key":"10.1016\/j.brainres.2018.02.018_b0470","doi-asserted-by":"crossref","DOI":"10.1038\/nature13124","article-title":"C9orf72 nucleotide repeat structures initiate molecular cascades of disease","author":"Haeusler","year":"2014","journal-title":"Nature"},{"key":"10.1016\/j.brainres.2018.02.018_b0475","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1038\/nrn.2016.38","article-title":"The expanding biology of the C9orf72 nucleotide repeat expansion in neurodegenerative disease","volume":"17","author":"Haeusler","year":"2016","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.brainres.2018.02.018_b0480","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1186\/1750-1326-9-15","article-title":"U1 small nuclear ribonucleoproteins (snRNPs) aggregate in Alzheimer's disease due to autosomal dominant genetic mutations and trisomy 21","volume":"9","author":"Hales","year":"2014","journal-title":"Mol. Neurodegener."},{"key":"10.1016\/j.brainres.2018.02.018_b0485","doi-asserted-by":"crossref","first-page":"768","DOI":"10.1016\/j.cell.2012.04.016","article-title":"Cell-free formation of RNA granules: bound RNAs identify features and components of cellular assemblies","volume":"149","author":"Han","year":"2012","journal-title":"Cell."},{"key":"10.1016\/j.brainres.2018.02.018_b0490","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.20609","article-title":"Unconventional secretory processing diversifies neuronal ion channel properties","volume":"5","author":"Hanus","year":"2016","journal-title":"Elife"},{"key":"10.1016\/j.brainres.2018.02.018_b0495","doi-asserted-by":"crossref","first-page":"1095","DOI":"10.1016\/S0896-6273(03)00770-0","article-title":"Axoplasmic importins enable retrograde injury signaling in lesioned nerve","volume":"40","author":"Hanz","year":"2003","journal-title":"Neuron"},{"key":"10.1016\/j.brainres.2018.02.018_b0500","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1093\/hmg\/ddu447","article-title":"Motoneuron development influences dorsal root ganglia survival and Schwann cell development in a vertebrate model of spinal muscular atrophy","volume":"24","author":"Hao le","year":"2015","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.brainres.2018.02.018_b0505","article-title":"HuD and the Survival Motor Neuron protein interact in motoneurons and are essential for motoneuron development, function and mRNA regulation","author":"Hao","year":"2017","journal-title":"J. Neurosci."},{"key":"10.1016\/j.brainres.2018.02.018_b0510","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1126\/science.1072994","article-title":"The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics","volume":"297","author":"Hardy","year":"2002","journal-title":"Science"},{"key":"10.1016\/j.brainres.2018.02.018_b0515","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1016\/j.neuron.2010.10.020","article-title":"Transsynaptic progression of amyloid-beta-induced neuronal dysfunction within the entorhinal-hippocampal network","volume":"68","author":"Harris","year":"2010","journal-title":"Neuron"},{"key":"10.1016\/j.brainres.2018.02.018_b0520","doi-asserted-by":"crossref","first-page":"1816","DOI":"10.1038\/sj.emboj.7601078","article-title":"Regulation of actin dynamics by annexin 2","volume":"25","author":"Hayes","year":"2006","journal-title":"EMBO J."},{"key":"10.1016\/j.brainres.2018.02.018_b0525","doi-asserted-by":"crossref","first-page":"5727","DOI":"10.1523\/JNEUROSCI.5229-05.2006","article-title":"Functional and selective RNA interference in developing axons and growth cones","volume":"26","author":"Hengst","year":"2006","journal-title":"J. Neurosci."},{"key":"10.1016\/j.brainres.2018.02.018_b0530","doi-asserted-by":"crossref","first-page":"1024","DOI":"10.1038\/ncb1916","article-title":"Axonal elongation triggered by stimulus-induced local translation of a polarity complex protein","volume":"11","author":"Hengst","year":"2009","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.brainres.2018.02.018_b0535","doi-asserted-by":"crossref","DOI":"10.1038\/nrm.2017.130","article-title":"A brave new world of RNA-binding proteins","author":"Hentze","year":"2018","journal-title":"Nat. Rev. Mol. Cell. Biol."},{"key":"10.1016\/j.brainres.2018.02.018_b0540","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1016\/j.tins.2014.05.009","article-title":"The multifunctional Staufen proteins: conserved roles from neurogenesis to synaptic plasticity","volume":"37","author":"Heraud-Farlow","year":"2014","journal-title":"Trend. Neurosci."},{"key":"10.1016\/j.brainres.2018.02.018_b0545","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1016\/j.brainres.2007.09.048","article-title":"Concurrence of TDP-43, tau and alpha-synuclein pathology in brains of Alzheimer's disease and dementia with Lewy bodies","volume":"1184","author":"Higashi","year":"2007","journal-title":"Brain Res."},{"key":"10.1016\/j.brainres.2018.02.018_b0550","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1038\/nrn1624","article-title":"Molecular motors and mechanisms of directional transport in neurons","volume":"6","author":"Hirokawa","year":"2005","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.brainres.2018.02.018_b0555","doi-asserted-by":"crossref","first-page":"648","DOI":"10.1016\/j.neuron.2013.10.036","article-title":"The central dogma decentralized: new perspectives on RNA function and local translation in neurons","volume":"80","author":"Holt","year":"2013","journal-title":"Neuron"},{"key":"10.1016\/j.brainres.2018.02.018_b0560","doi-asserted-by":"crossref","first-page":"20748","DOI":"10.1074\/jbc.M115.638023","article-title":"Glutamate Stimulates Local Protein Synthesis in the Axons of Rat Cortical Neurons by Activating alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid (AMPA) Receptors and Metabotropic Glutamate Receptors","volume":"290","author":"Hsu","year":"2015","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.brainres.2018.02.018_b0565","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.febslet.2004.07.010","article-title":"Survival motor neuron protein facilitates assembly of stress granules","volume":"572","author":"Hua","year":"2004","journal-title":"FEBS Lett."},{"key":"10.1016\/j.brainres.2018.02.018_b0570","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1093\/hmg\/ddq500","article-title":"HuD interacts with survival motor neuron protein and can rescue spinal muscular atrophy-like neuronal defects","volume":"20","author":"Hubers","year":"2011","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.brainres.2018.02.018_b0575","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1038\/nature04115","article-title":"Spatial regulation of beta-actin translation by Src-dependent phosphorylation of ZBP1","volume":"438","author":"Huttelmaier","year":"2005","journal-title":"Nature"},{"key":"10.1016\/j.brainres.2018.02.018_b0580","first-page":"181","article-title":"Risk factors for amyotrophic lateral sclerosis","volume":"7","author":"Ingre","year":"2015","journal-title":"Clin. Epidemiol."},{"key":"10.1016\/j.brainres.2018.02.018_b0585","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1111\/gtc.12352","article-title":"TDP-43 binds and transports G-quadruplex-containing mRNAs into neurites for local translation","volume":"21","author":"Ishiguro","year":"2016","journal-title":"Genes Cells"},{"key":"10.1016\/j.brainres.2018.02.018_b0590","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1093\/hmg\/10.5.497","article-title":"Co-regulation of survival of motor neuron (SMN) protein and its interactor SIP1 during development and in spinal muscular atrophy","volume":"10","author":"Jablonka","year":"2001","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.brainres.2018.02.018_b0595","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1002\/neu.10313","article-title":"Axonal defects in mouse models of motoneuron disease","volume":"58","author":"Jablonka","year":"2004","journal-title":"J. Neurobiol."},{"key":"10.1016\/j.brainres.2018.02.018_b0600","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1093\/hmg\/ddi467","article-title":"Distinct and overlapping alterations in motor and sensory neurons in a mouse model of spinal muscular atrophy","volume":"15","author":"Jablonka","year":"2006","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.brainres.2018.02.018_b0605","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1083\/jcb.200703187","article-title":"Defective Ca2+ channel clustering in axon terminals disturbs excitability in motoneurons in spinal muscular atrophy","volume":"179","author":"Jablonka","year":"2007","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.brainres.2018.02.018_b0610","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1016\/j.tig.2014.07.002","article-title":"mRNA transport meets membrane traffic","volume":"30","author":"Jansen","year":"2014","journal-title":"Trend. Genet."},{"key":"10.1016\/j.brainres.2018.02.018_b0615","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1016\/j.neuron.2004.12.051","article-title":"Coordinated motor neuron axon growth and neuromuscular synaptogenesis are promoted by CPG15 in vivo","volume":"45","author":"Javaherian","year":"2005","journal-title":"Neuron"},{"key":"10.1016\/j.brainres.2018.02.018_b0620","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1002\/dneu.22112","article-title":"Axonal transcription factors: Novel regulators of growth cone-to-nucleus signaling","volume":"74","author":"Ji","year":"2014","journal-title":"Dev. Neurobiol."},{"key":"10.1016\/j.brainres.2018.02.018_b0625","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1007\/s00401-013-1211-9","article-title":"Staging TDP-43 pathology in Alzheimer's disease","volume":"127","author":"Josephs","year":"2014","journal-title":"Acta Neuropathol."},{"key":"10.1016\/j.brainres.2018.02.018_b0630","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1007\/s00401-016-1537-1","article-title":"Updated TDP-43 in Alzheimer's disease staging scheme","volume":"131","author":"Josephs","year":"2016","journal-title":"Acta Neuropathol."},{"key":"10.1016\/j.brainres.2018.02.018_b0635","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1002\/dneu.22110","article-title":"RNA-binding protein Vg1RBP regulates terminal arbor formation but not long-range axon navigation in the developing visual system","volume":"74","author":"Kalous","year":"2014","journal-title":"Dev. Neurobiol."},{"key":"10.1016\/j.brainres.2018.02.018_b0640","doi-asserted-by":"crossref","first-page":"2004","DOI":"10.1016\/j.bbadis.2016.07.015","article-title":"Proteomic analysis of FUS interacting proteins provides insights into FUS function and its role in ALS","volume":"1862","author":"Kamelgarn","year":"2016","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.brainres.2018.02.018_b0645","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1016\/j.neuron.2004.07.022","article-title":"Kinesin transports RNA: isolation and characterization of an RNA-transporting granule","volume":"43","author":"Kanai","year":"2004","journal-title":"Neuron"},{"key":"10.1016\/j.brainres.2018.02.018_b0650","doi-asserted-by":"crossref","DOI":"10.1007\/s00439-017-1830-7","article-title":"Genetic mutations in RNA-binding proteins and their roles in ALS","author":"Kapeli","year":"2017","journal-title":"Hum. Genet."},{"key":"10.1016\/j.brainres.2018.02.018_b0655","doi-asserted-by":"crossref","first-page":"7165","DOI":"10.1523\/JNEUROSCI.2040-12.2013","article-title":"Intra-axonal synthesis of eukaryotic translation initiation factors regulate local protein synthesis and axon growth in rat sympathetic neurons","volume":"33","author":"Kar","year":"2013","journal-title":"J. Neurosci. Offic. J. Soc. Neurosci."},{"key":"10.1016\/j.brainres.2018.02.018_b0660","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1002\/dneu.22141","article-title":"Dysregulation of the axonal trafficking of nuclear-encoded mitochondrial mRNA alters neuronal mitochondrial activity and mouse behavior","volume":"74","author":"Kar","year":"2014","journal-title":"Dev. Neurobiol."},{"key":"10.1016\/j.brainres.2018.02.018_b0665","article-title":"Expanding axonal transcriptome brings new functions for axonally synthesized proteins in health and disease","author":"Kar","year":"2017","journal-title":"Neuroscientist"},{"key":"10.1016\/j.brainres.2018.02.018_b0670","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1016\/j.cell.2012.04.017","article-title":"Cell-free formation of RNA granules: low complexity sequence domains form dynamic fibers within hydrogels","volume":"149","author":"Kato","year":"2012","journal-title":"Cell"},{"key":"10.1016\/j.brainres.2018.02.018_b0675","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/j.neurobiolaging.2017.02.016","article-title":"Enhancing mitofusin\/Marf ameliorates neuromuscular dysfunction in Drosophila models of TDP-43 proteinopathies","volume":"54","author":"Khalil","year":"2017","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.brainres.2018.02.018_b9005","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1038\/nn.3606","article-title":"Molecular drivers and cortical spread of lateral entorhinal cortex dysfunction in preclinical Alzheimer's disease","volume":"17","author":"Khan","year":"2014","journal-title":"Nat Neurosci."},{"key":"10.1016\/j.brainres.2018.02.018_b0680","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1016\/j.neuron.2017.07.029","article-title":"Lost in transportation: nucleocytoplasmic transport defects in ALS and other neurodegenerative diseases","volume":"96","author":"Kim","year":"2017","journal-title":"Neuron"},{"key":"10.1016\/j.brainres.2018.02.018_b0685","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.brainres.2012.01.016","article-title":"The tip of the iceberg: RNA-binding proteins with prion-like domains in neurodegenerative disease","volume":"1462","author":"King","year":"2012","journal-title":"Brain Res."},{"key":"10.1016\/j.brainres.2018.02.018_b0690","doi-asserted-by":"crossref","first-page":"975","DOI":"10.1016\/0955-0674(92)90128-Y","article-title":"Determinants of mRNA localization","volume":"4","author":"Kislauskis","year":"1992","journal-title":"Curr. Opin. Cell. Biol."},{"key":"10.1016\/j.brainres.2018.02.018_b0695","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1111\/j.1471-4159.1967.tb09542.x","article-title":"Synthetic mechanisms in the axon. IV. In vitro incorporation of [3H]precursors into axonal protein and RNA","volume":"14","author":"Koenig","year":"1967","journal-title":"J. Neurochem."},{"key":"10.1016\/j.brainres.2018.02.018_b0700","doi-asserted-by":"crossref","first-page":"8390","DOI":"10.1523\/JNEUROSCI.20-22-08390.2000","article-title":"Cryptic peripheral ribosomal domains distributed intermittently along mammalian myelinated axons","volume":"20","author":"Koenig","year":"2000","journal-title":"J. Neurosci."},{"key":"10.1016\/j.brainres.2018.02.018_b0705","doi-asserted-by":"crossref","first-page":"979","DOI":"10.1001\/archneurol.2011.74","article-title":"Spinal muscular atrophy: a timely review","volume":"68","author":"Kolb","year":"2011","journal-title":"Arch. Neurol."},{"key":"10.1016\/j.brainres.2018.02.018_b0710","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1002\/ana.24453","article-title":"C9orf72 ablation in mice does not cause motor neuron degeneration or motor deficits","volume":"78","author":"Koppers","year":"2015","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.brainres.2018.02.018_b0715","doi-asserted-by":"crossref","first-page":"6318","DOI":"10.1093\/hmg\/ddu350","article-title":"SMN regulates axonal local translation via miR-183\/mTOR pathway","volume":"23","author":"Kye","year":"2014","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.brainres.2018.02.018_b0720","doi-asserted-by":"crossref","first-page":"796","DOI":"10.1523\/JNEUROSCI.3501-06.2007","article-title":"Abeta oligomer-induced aberrations in synapse composition, shape, and density provide a molecular basis for loss of connectivity in Alzheimer's disease","volume":"27","author":"Lacor","year":"2007","journal-title":"J. Neurosci."},{"key":"10.1016\/j.brainres.2018.02.018_b0725","doi-asserted-by":"crossref","first-page":"6448","DOI":"10.1073\/pnas.95.11.6448","article-title":"Diffusible, nonfibrillar ligands derived from Abeta1-42 are potent central nervous system neurotoxins","volume":"95","author":"Lambert","year":"1998","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"issue":"774\u2013788","key":"10.1016\/j.brainres.2018.02.018_b0730","first-page":"e17","article-title":"C9orf72 dipeptide repeats impair the assembly, dynamics, and function of membrane-less organelles","volume":"167","author":"Lee","year":"2016","journal-title":"Cell"},{"key":"10.1016\/j.brainres.2018.02.018_b0735","doi-asserted-by":"crossref","first-page":"1178","DOI":"10.1016\/j.celrep.2013.10.049","article-title":"Hexanucleotide repeats in ALS\/FTD form length-dependent RNA foci, sequester RNA binding proteins, and are neurotoxic","volume":"5","author":"Lee","year":"2013","journal-title":"Cell Rep."},{"key":"10.1016\/j.brainres.2018.02.018_b0740","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/0092-8674(95)90460-3","article-title":"Identification and characterization of a spinal muscular atrophy-determining gene","volume":"80","author":"Lefebvre","year":"1995","journal-title":"Cell"},{"key":"10.1016\/j.brainres.2018.02.018_b0745","doi-asserted-by":"crossref","first-page":"1247","DOI":"10.1038\/nn1775","article-title":"Asymmetrical beta-actin mRNA translation in growth cones mediates attractive turning to netrin-1","volume":"9","author":"Leung","year":"2006","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.brainres.2018.02.018_b0750","doi-asserted-by":"crossref","DOI":"10.1016\/j.semcdb.2014.04.026","article-title":"SMN control of RNP assembly: from post-transcriptional gene regulation to motor neuron disease","author":"Li","year":"2014","journal-title":"Semin. Cell. Dev. Biol"},{"key":"10.1016\/j.brainres.2018.02.018_b0755","doi-asserted-by":"crossref","first-page":"7295","DOI":"10.1093\/hmg\/ddv428","article-title":"alpha-COP binding to the survival motor neuron protein SMN is required for neuronal process outgrowth","volume":"24","author":"Li","year":"2015","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.brainres.2018.02.018_b0760","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1016\/j.molcel.2015.08.018","article-title":"Formation and maturation of phase-separated liquid droplets by RNA-binding proteins","volume":"60","author":"Lin","year":"2015","journal-title":"Mol. Cell."},{"key":"10.1016\/j.brainres.2018.02.018_b0765","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1016\/j.neuron.2013.07.033","article-title":"Converging mechanisms in ALS and FTD: disrupted RNA and protein homeostasis","volume":"79","author":"Ling","year":"2013","journal-title":"Neuron"},{"key":"10.1016\/j.brainres.2018.02.018_b0770","doi-asserted-by":"crossref","first-page":"1483","DOI":"10.1001\/archneurol.2009.277","article-title":"Transactive response DNA-binding protein 43 burden in familial Alzheimer disease and down syndrome","volume":"66","author":"Lippa","year":"2009","journal-title":"Arch. Neurol."},{"key":"10.1016\/j.brainres.2018.02.018_b0775","doi-asserted-by":"crossref","first-page":"4167","DOI":"10.1523\/JNEUROSCI.2350-13.2014","article-title":"ALS-linked mutations enlarge TDP-43-enriched neuronal RNA granules in the dendritic arbor","volume":"34","author":"Liu-Yesucevitz","year":"2014","journal-title":"J. Neurosci."},{"key":"10.1016\/j.brainres.2018.02.018_b0780","doi-asserted-by":"crossref","first-page":"3555","DOI":"10.1002\/j.1460-2075.1996.tb00725.x","article-title":"A novel nuclear structure containing the survival of motor neurons protein","volume":"15","author":"Liu","year":"1996","journal-title":"Embo J."},{"key":"10.1016\/j.brainres.2018.02.018_b0785","doi-asserted-by":"crossref","first-page":"1013","DOI":"10.1016\/S0092-8674(00)80367-0","article-title":"The spinal muscular atrophy disease gene product, SMN, and its associated protein SIP1 are in a complex with spliceosomal snRNP proteins","volume":"90","author":"Liu","year":"1997","journal-title":"Cell"},{"key":"10.1016\/j.brainres.2018.02.018_b0790","doi-asserted-by":"crossref","first-page":"6307","DOI":"10.1073\/pnas.96.11.6307","article-title":"A single nucleotide in the SMN gene regulates splicing and is responsible for spinal muscular atrophy","volume":"96","author":"Lorson","year":"1999","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.brainres.2018.02.018_b0795","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1093\/hmg\/9.2.259","article-title":"An exonic enhancer is required for inclusion of an essential exon in the SMA-determining gene SMN","volume":"9","author":"Lorson","year":"2000","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.brainres.2018.02.018_b0800","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1016\/j.cell.2012.09.012","article-title":"An SMN-dependent U12 splicing event essential for motor circuit function","volume":"151","author":"Lotti","year":"2012","journal-title":"Cell"},{"key":"10.1016\/j.brainres.2018.02.018_b0805","article-title":"The axonal endoplasmic reticulum: One organelle-many functions in development, maintenance, and plasticity","author":"Luarte","year":"2017","journal-title":"Dev. Neurobiol."},{"key":"10.1016\/j.brainres.2018.02.018_b0810","doi-asserted-by":"crossref","first-page":"730","DOI":"10.1097\/01.jnen.0000174335.27708.0a","article-title":"Ubiquitin immunohistochemistry suggests classic motor neuron disease, motor neuron disease with dementia, and frontotemporal dementia of the motor neuron disease type represent a clinicopathologic spectrum","volume":"64","author":"Mackenzie","year":"2005","journal-title":"J. Neuropathol. Exp. Neurol."},{"issue":"808\u2013816","key":"10.1016\/j.brainres.2018.02.018_b0815","first-page":"e9","article-title":"TIA1 mutations in amyotrophic lateral sclerosis and frontotemporal dementia promote phase separation and alter stress granule dynamics","volume":"95","author":"Mackenzie","year":"2017","journal-title":"Neuron"},{"key":"10.1016\/j.brainres.2018.02.018_b0820","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1016\/j.neuron.2014.10.019","article-title":"Axonal transport: cargo-specific mechanisms of motility and regulation","volume":"84","author":"Maday","year":"2014","journal-title":"Neuron"},{"key":"10.1016\/j.brainres.2018.02.018_b0825","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1016\/j.cell.2009.01.044","article-title":"mRNA localization: gene expression in the spatial dimension","volume":"136","author":"Martin","year":"2009","journal-title":"Cell"},{"key":"10.1016\/j.brainres.2018.02.018_b0830","doi-asserted-by":"crossref","first-page":"919","DOI":"10.1083\/jcb.200303168","article-title":"Knockdown of the survival motor neuron (Smn) protein in zebrafish causes defects in motor axon outgrowth and pathfinding","volume":"162","author":"McWhorter","year":"2003","journal-title":"J. Cell. Biol."},{"key":"10.1016\/j.brainres.2018.02.018_b0835","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1007\/s12264-013-1360-9","article-title":"Peripheral nerve axons contain machinery for co-translational secretion of axonally-generated proteins","volume":"29","author":"Merianda","year":"2013","journal-title":"Neurosci. Bull."},{"key":"10.1016\/j.brainres.2018.02.018_b0840","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1016\/j.mcn.2008.09.008","article-title":"A functional equivalent of endoplasmic reticulum and Golgi in axons for secretion of locally synthesized proteins","volume":"40","author":"Merianda","year":"2009","journal-title":"Mol. Cell. Neurosci."},{"key":"10.1016\/j.brainres.2018.02.018_b0845","doi-asserted-by":"crossref","first-page":"13735","DOI":"10.1523\/JNEUROSCI.0962-13.2013","article-title":"Axonal localization of neuritin\/CPG15 mRNA in neuronal populations through distinct 5' and 3' UTR elements","volume":"33","author":"Merianda","year":"2013","journal-title":"J. Neurosci."},{"key":"10.1016\/j.brainres.2018.02.018_b0850","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1038\/nature06888","article-title":"Genome-wide screen reveals APC-associated RNAs enriched in cell protrusions","volume":"453","author":"Mili","year":"2008","journal-title":"Nature"},{"key":"10.1016\/j.brainres.2018.02.018_b0855","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1002\/dneu.22140","article-title":"Subcellular transcriptomics-dissection of the mRNA composition in the axonal compartment of sensory neurons","volume":"74","author":"Minis","year":"2014","journal-title":"Dev. Neurobiol."},{"key":"10.1016\/j.brainres.2018.02.018_b0860","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12964-015-0125-7","article-title":"Phase separation in biology; functional organization of a higher order","volume":"14","author":"Mitrea","year":"2016","journal-title":"Cell. Commun. Signal."},{"key":"10.1016\/j.brainres.2018.02.018_b0865","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/j.cell.2015.09.015","article-title":"Phase separation by low complexity domains promotes stress granule assembly and drives pathological fibrillization","volume":"163","author":"Molliex","year":"2015","journal-title":"Cell"},{"key":"10.1016\/j.brainres.2018.02.018_b0870","doi-asserted-by":"crossref","first-page":"1177","DOI":"10.1093\/hmg\/8.7.1177","article-title":"A single nucleotide difference that alters splicing patterns distinguishes the SMA gene SMN1 from the copy gene SMN2","volume":"8","author":"Monani","year":"1999","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.brainres.2018.02.018_b0875","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1136\/jnnp-2013-307223","article-title":"Cognitive correlates in amyotrophic lateral sclerosis: a population-based study in Italy","volume":"86","author":"Montuschi","year":"2015","journal-title":"J. Neurol. Neurosurg. Psychiat."},{"key":"10.1016\/j.brainres.2018.02.018_b0880","doi-asserted-by":"crossref","first-page":"688","DOI":"10.1016\/j.cell.2009.02.001","article-title":"Pre-mRNA processing reaches back to transcription and ahead to translation","volume":"136","author":"Moore","year":"2009","journal-title":"Cell"},{"key":"10.1016\/j.brainres.2018.02.018_b0885","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1083\/jcb.201604117","article-title":"Differential roles of alpha-, beta-, and gamma-actin in axon growth and collateral branch formation in motoneurons","volume":"216","author":"Moradi","year":"2017","journal-title":"J. Cell. Biol."},{"key":"10.1016\/j.brainres.2018.02.018_b0890","doi-asserted-by":"crossref","first-page":"881","DOI":"10.1007\/s00401-013-1189-3","article-title":"Bidirectional transcripts of the expanded C9orf72 hexanucleotide repeat are translated into aggregating dipeptide repeat proteins","volume":"126","author":"Mori","year":"2013","journal-title":"Acta Neuropathol."},{"key":"10.1016\/j.brainres.2018.02.018_b0895","doi-asserted-by":"crossref","first-page":"1335","DOI":"10.1126\/science.1232927","article-title":"The C9orf72 GGGGCC repeat is translated into aggregating dipeptide-repeat proteins in FTLD\/ALS","volume":"339","author":"Mori","year":"2013","journal-title":"Science"},{"key":"10.1016\/j.brainres.2018.02.018_b0900","doi-asserted-by":"crossref","first-page":"5443","DOI":"10.1093\/emboj\/20.19.5443","article-title":"SMN interacts with a novel family of hnRNP and spliceosomal proteins","volume":"20","author":"Mourelatos","year":"2001","journal-title":"Embo J."},{"key":"10.1016\/j.brainres.2018.02.018_b0905","doi-asserted-by":"crossref","first-page":"678","DOI":"10.1016\/j.neuron.2015.10.030","article-title":"ALS\/FTD mutation-induced phase transition of FUS liquid droplets and reversible hydrogels into irreversible hydrogels impairs RNP granule function","volume":"88","author":"Murakami","year":"2015","journal-title":"Neuron"},{"key":"10.1016\/j.brainres.2018.02.018_b0910","doi-asserted-by":"crossref","first-page":"656","DOI":"10.1096\/fj.06-6155com","article-title":"RNAi pathway is functional in peripheral nerve axons","volume":"21","author":"Murashov","year":"2007","journal-title":"FASEB J."},{"key":"10.1016\/j.brainres.2018.02.018_b0915","doi-asserted-by":"crossref","first-page":"252","DOI":"10.3109\/21678421.2012.734520","article-title":"Identification of RNA bound to the TDP-43 ribonucleoprotein complex in the adult mouse brain","volume":"14","author":"Narayanan","year":"2013","journal-title":"Amyot. Lateral Scler Frontotemp. Deg."},{"key":"10.1016\/j.brainres.2018.02.018_b0920","doi-asserted-by":"crossref","first-page":"2922","DOI":"10.1093\/brain\/awp214","article-title":"A new subtype of frontotemporal lobar degeneration with FUS pathology","volume":"132","author":"Neumann","year":"2009","journal-title":"Brain"},{"key":"10.1016\/j.brainres.2018.02.018_b0925","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1111\/nyas.12638","article-title":"Frontotemporal dementia: a bridge between dementia and neuromuscular disease","volume":"1338","author":"Ng","year":"2015","journal-title":"Ann. NY Acad. Sci."},{"key":"10.1016\/j.brainres.2018.02.018_b0930","doi-asserted-by":"crossref","first-page":"3159","DOI":"10.1093\/hmg\/ddq226","article-title":"PTEN depletion rescues axonal growth defect and improves survival in SMN-deficient motor neurons","volume":"19","author":"Ning","year":"2010","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.brainres.2018.02.018_b9015","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.26376","article-title":"Microtubule-dependent ribosome localization in C. elegans neurons","volume":"6","author":"Noma","year":"2017","journal-title":"Elife."},{"key":"10.1016\/j.brainres.2018.02.018_b0935","doi-asserted-by":"crossref","first-page":"1324","DOI":"10.1126\/science.aaf1064","article-title":"C9orf72 is required for proper macrophage and microglial function in mice","volume":"351","author":"O'Rourke","year":"2016","journal-title":"Science"},{"key":"10.1016\/j.brainres.2018.02.018_b0940","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1093\/hmg\/9.1.47","article-title":"Subcellular localization and axonal transport of the survival motor neuron (SMN) protein in the developing rat spinal cord","volume":"9","author":"Pagliardini","year":"2000","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.brainres.2018.02.018_b0945","doi-asserted-by":"crossref","first-page":"1066","DOI":"10.1016\/j.cell.2015.07.047","article-title":"A liquid-to-solid phase transition of the ALS protein FUS accelerated by disease mutation","volume":"162","author":"Patel","year":"2015","journal-title":"Cell"},{"issue":"373\u2013386","key":"10.1016\/j.brainres.2018.02.018_b0950","first-page":"e6","article-title":"Paclitaxel reduces axonal Bclw to initiate IP3R1-dependent axon degeneration","volume":"96","author":"Pease-Raissi","year":"2017","journal-title":"Neuron"},{"key":"10.1016\/j.brainres.2018.02.018_b0955","doi-asserted-by":"crossref","first-page":"1701","DOI":"10.1093\/hmg\/ddr046","article-title":"The COPI vesicle complex binds and moves with survival motor neuron within axons","volume":"20","author":"Peter","year":"2011","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.brainres.2018.02.018_b0960","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1136\/jnnp-2011-300188","article-title":"The syndrome of cognitive impairment in amyotrophic lateral sclerosis: a population-based study","volume":"83","author":"Phukan","year":"2012","journal-title":"J Neurol. Neurosurg. Psychiat."},{"key":"10.1016\/j.brainres.2018.02.018_b0965","doi-asserted-by":"crossref","first-page":"5598","DOI":"10.1074\/jbc.M707304200","article-title":"In vitro and in cellulo evidences for association of the survival of motor neuron complex with the fragile X mental retardation protein","volume":"283","author":"Piazzon","year":"2008","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.brainres.2018.02.018_b0970","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1186\/s13064-015-0031-0","article-title":"Differential requirement of F-actin and microtubule cytoskeleton in cue-induced local protein synthesis in axonal growth cones","volume":"10","author":"Piper","year":"2015","journal-title":"Neural Dev."},{"key":"10.1016\/j.brainres.2018.02.018_b0975","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1038\/nn.2779","article-title":"Long pre-mRNA depletion and RNA missplicing contribute to neuronal vulnerability from loss of TDP-43","volume":"14","author":"Polymenidou","year":"2011","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.brainres.2018.02.018_b0980","doi-asserted-by":"crossref","first-page":"16937","DOI":"10.1074\/jbc.M113.463711","article-title":"beta-Amyloid (Abeta) oligomers impair brain-derived neurotrophic factor retrograde trafficking by down-regulating ubiquitin C-terminal hydrolase, UCH-L1","volume":"288","author":"Poon","year":"2013","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.brainres.2018.02.018_b0985","doi-asserted-by":"crossref","first-page":"624","DOI":"10.1016\/j.celrep.2012.05.014","article-title":"A Drosophila model of spinal muscular atrophy uncouples snRNP biogenesis functions of survival motor neuron from locomotion and viability defects","volume":"1","author":"Praveen","year":"2012","journal-title":"Cell Rep."},{"key":"10.1016\/j.brainres.2018.02.018_b0990","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1016\/j.cell.2014.05.042","article-title":"APC is an RNA-binding protein, and its interactome provides a link to neural development and microtubule assembly","volume":"158","author":"Preitner","year":"2014","journal-title":"Cell"},{"key":"10.1016\/j.brainres.2018.02.018_b0995","doi-asserted-by":"crossref","first-page":"1608","DOI":"10.1002\/ajmg.a.33474","article-title":"Newborn and carrier screening for spinal muscular atrophy","volume":"152A","author":"Prior","year":"2010","journal-title":"Am. J. Med. Genet A."},{"key":"10.1016\/j.brainres.2018.02.018_b1000","doi-asserted-by":"crossref","first-page":"1755","DOI":"10.1261\/rna.040204.113","article-title":"Genome-wide identification of mRNAs associated with the protein SMN whose depletion decreases their axonal localization","volume":"19","author":"Rage","year":"2013","journal-title":"RNA"},{"key":"10.1016\/j.brainres.2018.02.018_b1005","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1016\/j.cell.2013.07.038","article-title":"Altered ribostasis: RNA-protein granules in degenerative disorders","volume":"154","author":"Ramaswami","year":"2013","journal-title":"Cell"},{"key":"10.1016\/j.brainres.2018.02.018_b1010","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1007\/s00418-012-0989-1","article-title":"Laminin induced local axonal translation of beta-actin mRNA is impaired in SMN-deficient motoneurons","volume":"138","author":"Rathod","year":"2012","journal-title":"Histochem. Cell Biol."},{"issue":"Suppl 1","key":"10.1016\/j.brainres.2018.02.018_b1015","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1111\/jnc.13625","article-title":"Physiological functions and pathobiology of TDP-43 and FUS\/TLS proteins","volume":"138","author":"Ratti","year":"2016","journal-title":"J. Neurochem."},{"key":"10.1016\/j.brainres.2018.02.018_b1020","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/j.neuron.2011.09.010","article-title":"A hexanucleotide repeat expansion in C9ORF72 is the cause of chromosome 9p21-linked ALS-FTD","volume":"72","author":"Renton","year":"2011","journal-title":"Neuron"},{"key":"10.1016\/j.brainres.2018.02.018_b1025","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1111\/tra.12385","article-title":"Engineered Tug-of-War between Kinesin and Dynein controls direction of microtubule based transport In vivo","volume":"17","author":"Rezaul","year":"2016","journal-title":"Traffic"},{"key":"10.1016\/j.brainres.2018.02.018_b1030","doi-asserted-by":"crossref","first-page":"1097","DOI":"10.1126\/science.277.5329.1097","article-title":"An NGF-TrkA-mediated retrograde signal to transcription factor CREB in sympathetic neurons","volume":"277","author":"Riccio","year":"1997","journal-title":"Science"},{"key":"10.1016\/j.brainres.2018.02.018_b1035","doi-asserted-by":"crossref","first-page":"586","DOI":"10.1212\/01.wnl.0000172911.39167.b6","article-title":"Prevalence and patterns of cognitive impairment in sporadic ALS","volume":"65","author":"Ringholz","year":"2005","journal-title":"Neurology"},{"key":"10.1016\/j.brainres.2018.02.018_b1040","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1038\/nrn3609","article-title":"Axon-soma communication in neuronal injury","volume":"15","author":"Rishal","year":"2014","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.brainres.2018.02.018_b1045","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.nbd.2014.07.007","article-title":"Chronological requirements of TDP-43 function in synaptic organization and locomotive control","volume":"71C","author":"Romano","year":"2014","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.brainres.2018.02.018_b1050","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1016\/S0896-6273(00)81170-8","article-title":"Drosophila Futsch regulates synaptic microtubule organization and is necessary for synaptic growth","volume":"26","author":"Roos","year":"2000","journal-title":"Neuron"},{"key":"10.1016\/j.brainres.2018.02.018_b1055","first-page":"1787","article-title":"Nuclear accumulation of mRNAs underlies G4C2-repeat-induced translational repression in a cellular model of C9orf72 ALS","volume":"128","author":"Rossi","year":"2015","journal-title":"J. Cell Sci."},{"key":"10.1016\/j.brainres.2018.02.018_b1060","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1093\/hmg\/11.1.93","article-title":"Specific interaction of Smn, the spinal muscular atrophy determining gene product, with hnRNP-R and gry-rbp\/hnRNP-Q: a role for Smn in RNA processing in motor axons?","volume":"11","author":"Rossoll","year":"2002","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.brainres.2018.02.018_b1065","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1083\/jcb.200304128","article-title":"Smn, the spinal muscular atrophy-determining gene product, modulates axon growth and localization of beta-actin mRNA in growth cones of motoneurons","volume":"163","author":"Rossoll","year":"2003","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.brainres.2018.02.018_b1070","doi-asserted-by":"crossref","DOI":"10.1007\/400_2009_4","article-title":"Spinal muscular atrophy and a model for survival of motor neuron protein function in axonal ribonucleoprotein complexes","author":"Rossoll","year":"2009","journal-title":"Result. Probl. Cell Differ."},{"key":"10.1016\/j.brainres.2018.02.018_b1075","doi-asserted-by":"crossref","first-page":"44500","DOI":"10.1038\/srep44500","article-title":"ALS along the axons \u2013 expression of coding and noncoding RNA differs in axons of ALS models","volume":"7","author":"Rotem","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.brainres.2018.02.018_b1080","doi-asserted-by":"crossref","first-page":"946","DOI":"10.1177\/0883073807305673","article-title":"Spinal muscular atrophy: clinical classification and disease heterogeneity","volume":"22","author":"Russman","year":"2007","journal-title":"J. Child. Neurol."},{"key":"10.1016\/j.brainres.2018.02.018_b1085","doi-asserted-by":"crossref","first-page":"99","DOI":"10.2217\/bmm.09.92","article-title":"Correlating familial Alzheimer's disease gene mutations with clinical phenotype","volume":"4","author":"Ryan","year":"2010","journal-title":"Biomark Med."},{"key":"10.1016\/j.brainres.2018.02.018_b1090","doi-asserted-by":"crossref","first-page":"1789","DOI":"10.1261\/rna.047373.114","article-title":"Subcellular transcriptome alterations in a cell culture model of spinal muscular atrophy point to widespread defects in axonal growth and presynaptic differentiation","volume":"20","author":"Saal","year":"2014","journal-title":"RNA"},{"key":"10.1016\/j.brainres.2018.02.018_b1095","article-title":"Sense-encoded poly-GR dipeptide repeat proteins correlate to neurodegeneration and uniquely co-localize with TDP-43 in dendrites of repeat-expanded C9orf72 amyotrophic lateral sclerosis","author":"Saberi","year":"2017","journal-title":"Acta Neuropathol."},{"key":"10.1016\/j.brainres.2018.02.018_b1100","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1002\/cm.20272","article-title":"Myosin-Va mediates RNA distribution in primary fibroblasts from multiple organs","volume":"65","author":"Salerno","year":"2008","journal-title":"Cell Motil. Cytoskel"},{"key":"10.1016\/j.brainres.2018.02.018_b1105","doi-asserted-by":"crossref","first-page":"668","DOI":"10.1093\/hmg\/dds474","article-title":"A novel function for the survival motoneuron protein as a translational regulator","volume":"22","author":"Sanchez","year":"2013","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.brainres.2018.02.018_b1110","doi-asserted-by":"crossref","first-page":"13939","DOI":"10.1073\/pnas.0907143106","article-title":"Cell-type-specific isolation of ribosome-associated mRNA from complex tissues","volume":"106","author":"Sanz","year":"2009","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.brainres.2018.02.018_b1115","doi-asserted-by":"crossref","first-page":"208ra149","DOI":"10.1126\/scitranslmed.3007529","article-title":"Targeting RNA foci in iPSC-derived motor neurons from ALS patients with a C9ORF72 repeat expansion","volume":"5","author":"Sareen","year":"2013","journal-title":"Sci Transl Med."},{"key":"10.1016\/j.brainres.2018.02.018_b1120","doi-asserted-by":"crossref","first-page":"9349","DOI":"10.1523\/JNEUROSCI.0499-10.2010","article-title":"Phosphorylation of zipcode binding protein 1 is required for brain-derived neurotrophic factor signaling of local beta-actin synthesis and growth cone turning","volume":"30","author":"Sasaki","year":"2010","journal-title":"J. Neurosci."},{"key":"10.1016\/j.brainres.2018.02.018_b1125","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1002\/dneu.22113","article-title":"Identification of axon-enriched microRNAs localized to growth cones of cortical neurons","volume":"74","author":"Sasaki","year":"2014","journal-title":"Dev. Neurobiol."},{"key":"10.1016\/j.brainres.2018.02.018_b1130","first-page":"496","article-title":"Super-resolution microscopy reveals presynaptic localization of the ALS\/FTD related protein FUS in hippocampal neurons","volume":"9","author":"Schoen","year":"2015","journal-title":"Front. Cell Neurosci."},{"key":"10.1016\/j.brainres.2018.02.018_b1135","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1038\/nature04367","article-title":"A brain-specific microRNA regulates dendritic spine development","volume":"439","author":"Schratt","year":"2006","journal-title":"Nature"},{"key":"10.1016\/j.brainres.2018.02.018_b1140","doi-asserted-by":"crossref","first-page":"1159","DOI":"10.1097\/NEN.0b013e31818e8951","article-title":"Colocalization of transactivation-responsive DNA-binding protein 43 and huntingtin in inclusions of Huntington disease","volume":"67","author":"Schwab","year":"2008","journal-title":"J. Neuropathol. Exp. Neurol."},{"key":"10.1016\/j.brainres.2018.02.018_b1145","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1146\/annurev-biochem-060614-034325","article-title":"Biochemical properties and biological functions of FET Proteins","volume":"84","author":"Schwartz","year":"2015","journal-title":"Annu. Rev. Biochem."},{"key":"10.1016\/j.brainres.2018.02.018_b1150","doi-asserted-by":"crossref","first-page":"1754","DOI":"10.1093\/hmg\/ddt567","article-title":"SMN deficiency alters Nrxn2 expression and splicing in zebrafish and mouse models of spinal muscular atrophy","volume":"23","author":"See","year":"2014","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.brainres.2018.02.018_b1155","doi-asserted-by":"crossref","first-page":"1204","DOI":"10.1074\/jbc.M110.190884","article-title":"Identification of neuronal RNA targets of TDP-43-containing ribonucleoprotein complexes","volume":"286","author":"Sephton","year":"2011","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.brainres.2018.02.018_b1160","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1111\/joa.12083","article-title":"Spinal muscular atrophy: a motor neuron disorder or a multi-organ disease?","volume":"224","author":"Shababi","year":"2014","journal-title":"J. Anat."},{"key":"10.1016\/j.brainres.2018.02.018_b1165","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/j.yexcr.2005.05.014","article-title":"A role for complexes of survival of motor neurons (SMN) protein with gemins and profilin in neurite-like cytoplasmic extensions of cultured nerve cells","volume":"309","author":"Sharma","year":"2005","journal-title":"Exp. Cell Res."},{"key":"10.1016\/j.brainres.2018.02.018_b1170","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/j.cell.2016.05.029","article-title":"Dynamic axonal translation in developing and mature visual circuits","volume":"166","author":"Shigeoka","year":"2016","journal-title":"Cell"},{"key":"10.1016\/j.brainres.2018.02.018_b1175","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1007\/978-1-4939-7213-5_5","article-title":"Axon-TRAP-RiboTag: affinity purification of translated mRNAs from neuronal axons in mouse in vivo","volume":"1649","author":"Shigeoka","year":"2018","journal-title":"Methods Mol. Biol."},{"key":"10.1016\/j.brainres.2018.02.018_b1180","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1016\/j.molmed.2016.05.005","article-title":"Hypo- and hyper-assembly diseases of RNA-protein complexes","volume":"22","author":"Shukla","year":"2016","journal-title":"Trends Mol. Med."},{"key":"10.1016\/j.brainres.2018.02.018_b9020","doi-asserted-by":"crossref","first-page":"870","DOI":"10.1093\/hmg\/ddt478","article-title":"Functional screening in Drosophila identifies Alzheimer's disease susceptibility genes and implicates Tau-mediated mechanisms","volume":"23","author":"Shulman","year":"2014","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.brainres.2018.02.018_b1185","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1146\/annurev-biochem-080111-092106","article-title":"The clothes make the mRNA: past and present trends in mRNP fashion","volume":"84","author":"Singh","year":"2015","journal-title":"Annu. Rev. Biochem."},{"key":"10.1016\/j.brainres.2018.02.018_b1190","doi-asserted-by":"crossref","first-page":"1610","DOI":"10.1038\/nn.4407","article-title":"C9ORF72 interaction with cofilin modulates actin dynamics in motor neurons","volume":"19","author":"Sivadasan","year":"2016","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.brainres.2018.02.018_b1195","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1016\/j.pneurobio.2009.07.006","article-title":"Stretch growth of integrated axon tracts: extremes and exploitations","volume":"89","author":"Smith","year":"2009","journal-title":"Prog. Neurobiol."},{"key":"10.1016\/j.brainres.2018.02.018_b1200","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1111\/j.1471-4159.2007.04999.x","article-title":"Myelinated axons contain beta-actin mRNA and ZBP-1 in periaxoplasmic ribosomal plaques and depend on cyclic AMP and F-actin integrity for in vitro translation","volume":"104","author":"Sotelo-Silveira","year":"2008","journal-title":"J. Neurochem."},{"key":"10.1016\/j.brainres.2018.02.018_b1205","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1002\/neu.20015","article-title":"Myosin Va and kinesin II motor proteins are concentrated in ribosomal domains (periaxoplasmic ribosomal plaques) of myelinated axons","volume":"60","author":"Sotelo-Silveira","year":"2004","journal-title":"J. Neurobiol."},{"key":"10.1016\/j.brainres.2018.02.018_b1210","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1523\/JNEUROSCI.02-03-00284.1982","article-title":"Preferential localization of polyribosomes under the base of dendritic spines in granule cells of the dentate gyrus","volume":"2","author":"Steward","year":"1982","journal-title":"J. Neurosci."},{"key":"10.1016\/j.brainres.2018.02.018_b1215","doi-asserted-by":"crossref","first-page":"1282","DOI":"10.1126\/science.1105681","article-title":"Axonopathy and transport deficits early in the pathogenesis of Alzheimer's disease","volume":"307","author":"Stokin","year":"2005","journal-title":"Science"},{"key":"10.1016\/j.brainres.2018.02.018_b1220","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1016\/j.mcn.2007.03.007","article-title":"TDP43 is a human low molecular weight neurofilament (hNFL) mRNA-binding protein","volume":"35","author":"Strong","year":"2007","journal-title":"Mol. Cell Neurosci."},{"key":"10.1016\/j.brainres.2018.02.018_b1225","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1186\/s40478-016-0324-5","article-title":"The ALS\/FTLD associated protein C9orf72 associates with SMCR8 and WDR41 to regulate the autophagy-lysosome pathway","volume":"4","author":"Sullivan","year":"2016","journal-title":"Acta Neuropathol. Commun."},{"key":"10.1016\/j.brainres.2018.02.018_b1230","doi-asserted-by":"crossref","first-page":"6171","DOI":"10.1038\/ncomms7171","article-title":"ALS-causative mutations in FUS\/TLS confer gain and loss of function by altered association with SMN and U1-snRNP","volume":"6","author":"Sun","year":"2015","journal-title":"Nat. Commun."},{"key":"10.1016\/j.brainres.2018.02.018_b1235","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1093\/hmg\/ddm327","article-title":"KH-type splicing regulatory protein interacts with survival motor neuron protein and is misregulated in spinal muscular atrophy","volume":"17","author":"Tadesse","year":"2008","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.brainres.2018.02.018_b1240","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1016\/j.molcel.2016.01.020","article-title":"Distal alternative last exons localize mRNAs to neural projections","volume":"61","author":"Taliaferro","year":"2016","journal-title":"Mol Cell."},{"key":"10.1016\/j.brainres.2018.02.018_b1245","doi-asserted-by":"crossref","first-page":"4697","DOI":"10.1523\/JNEUROSCI.6130-08.2009","article-title":"Axonal mRNA in uninjured and regenerating cortical mammalian axons","volume":"29","author":"Taylor","year":"2009","journal-title":"J. Neurosci."},{"key":"10.1016\/j.brainres.2018.02.018_b1250","doi-asserted-by":"crossref","first-page":"5584","DOI":"10.1523\/JNEUROSCI.2944-12.2013","article-title":"Axonal translation of beta-catenin regulates synaptic vesicle dynamics","volume":"33","author":"Taylor","year":"2013","journal-title":"J. Neurosci."},{"key":"10.1016\/j.brainres.2018.02.018_b1255","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1038\/nature20413","article-title":"Decoding ALS: from genes to mechanism","volume":"539","author":"Taylor","year":"2016","journal-title":"Nature"},{"key":"10.1016\/j.brainres.2018.02.018_b1260","doi-asserted-by":"crossref","first-page":"632","DOI":"10.1016\/j.cell.2010.04.008","article-title":"Transmembrane receptor DCC associates with protein synthesis machinery and regulates translation","volume":"141","author":"Tcherkezian","year":"2010","journal-title":"Cell"},{"key":"10.1016\/j.brainres.2018.02.018_b1265","doi-asserted-by":"crossref","first-page":"1495","DOI":"10.1016\/S0002-9440(10)64788-8","article-title":"Prominent axonopathy and disruption of axonal transport in transgenic mice expressing human apolipoprotein E4 in neurons of brain and spinal cord","volume":"157","author":"Tesseur","year":"2000","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.brainres.2018.02.018_b1270","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1093\/hmg\/dds480","article-title":"COPI transport complexes bind to specific RNAs in neuronal cells","volume":"22","author":"Todd","year":"2013","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.brainres.2018.02.018_b1275","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.nbd.2014.01.004","article-title":"Tar DNA-binding protein-43 (TDP-43) regulates axon growth in vitro and in vivo","volume":"65","author":"Tripathi","year":"2014","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.brainres.2018.02.018_b1280","doi-asserted-by":"crossref","first-page":"1365","DOI":"10.4103\/1673-5374.191193","article-title":"Intra-axonal protein synthesis - a new target for neural repair?","volume":"11","author":"Twiss","year":"2016","journal-title":"Neur. Regen. Res."},{"key":"10.1016\/j.brainres.2018.02.018_b1285","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1097\/NEN.0b013e31817713b5","article-title":"Concomitant TAR-DNA-binding protein 43 pathology is present in Alzheimer disease and corticobasal degeneration but not in other tauopathies","volume":"67","author":"Uryu","year":"2008","journal-title":"J. Neuropathol. Exp. Neurol."},{"key":"10.1016\/j.brainres.2018.02.018_b1290","doi-asserted-by":"crossref","first-page":"1455","DOI":"10.1016\/j.celrep.2016.04.045","article-title":"Interaction of tau with the RNA-binding protein TIA1 regulates tau pathophysiology and toxicity","volume":"15","author":"Vanderweyde","year":"2016","journal-title":"Cell Rep."},{"key":"10.1016\/j.brainres.2018.02.018_b1295","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1523\/JNEUROSCI.3073-04.2005","article-title":"Axonal protein synthesis and degradation are necessary for efficient growth cone regeneration","volume":"25","author":"Verma","year":"2005","journal-title":"J. Neurosci."},{"key":"10.1016\/j.brainres.2018.02.018_b1300","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1016\/j.brainres.2009.09.105","article-title":"Tar DNA binding protein of 43 kDa (TDP-43), 14-3-3 proteins and copper\/zinc superoxide dismutase (SOD1) interact to modulate NFL mRNA stability. Implications for altered RNA processing in amyotrophic lateral sclerosis (ALS)","volume":"1305","author":"Volkening","year":"2009","journal-title":"Brain Res."},{"key":"10.1016\/j.brainres.2018.02.018_b1305","doi-asserted-by":"crossref","DOI":"10.1016\/j.neurobiolaging.2014.01.016","article-title":"Reduced C9orf72 protein levels in frontal cortex of amyotrophic lateral sclerosis and frontotemporal degeneration brain with the C9ORF72 hexanucleotide repeat expansion","volume":"35","author":"Waite","year":"2014","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.brainres.2018.02.018_b1310","doi-asserted-by":"crossref","first-page":"11418","DOI":"10.1523\/JNEUROSCI.2352-16.2016","article-title":"Dysregulation of mRNA localization and translation in genetic disease","volume":"36","author":"Wang","year":"2016","journal-title":"J. Neurosci."},{"key":"10.1016\/j.brainres.2018.02.018_b1315","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1111\/j.1471-4159.2007.05190.x","article-title":"TDP-43, the signature protein of FTLD-U, is a neuronal activity-responsive factor","volume":"105","author":"Wang","year":"2008","journal-title":"J. Neurochem."},{"key":"10.1016\/j.brainres.2018.02.018_b1320","doi-asserted-by":"crossref","unstructured":"Wedel, M., 2012. A Monument of Inefficiency: The Presumed Course of the Recurrent Laryngeal Nerve in Sauropod Dinosaurs, vol. 57.","DOI":"10.4202\/app.2011.0019"},{"key":"10.1016\/j.brainres.2018.02.018_b1325","doi-asserted-by":"crossref","first-page":"9800","DOI":"10.1523\/JNEUROSCI.0166-11.2011","article-title":"Netrin-1-Induced Local {beta}-Actin Synthesis and Growth Cone Guidance Requires Zipcode Binding Protein 1","volume":"31","author":"Welshhans","year":"2011","journal-title":"J. Neurosci."},{"key":"10.1016\/j.brainres.2018.02.018_b1330","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/j.neulet.2016.09.007","article-title":"Pathogenic determinants and mechanisms of ALS\/FTD linked to hexanucleotide repeat expansions in the C9orf72 gene","volume":"636","author":"Wen","year":"2017","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.brainres.2018.02.018_b1335","doi-asserted-by":"crossref","first-page":"965","DOI":"10.1083\/jcb.200703209","article-title":"Extracellular stimuli specifically regulate localized levels of individual neuronal mRNAs","volume":"178","author":"Willis","year":"2007","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.brainres.2018.02.018_b1340","first-page":"147","article-title":"TDP-43 in aging and Alzheimer's disease \u2013 a review","volume":"4","author":"Wilson","year":"2011","journal-title":"Int. J. Clin. Exp. Pathol."},{"key":"10.1016\/j.brainres.2018.02.018_b1345","doi-asserted-by":"crossref","first-page":"1418","DOI":"10.1001\/jamaneurol.2013.3961","article-title":"TDP-43 pathology, cognitive decline, and dementia in old age","volume":"70","author":"Wilson","year":"2013","journal-title":"JAMA Neurol."},{"issue":"852\u2013868","key":"10.1016\/j.brainres.2018.02.018_b1350","first-page":"e8","article-title":"RNA docking and local translation regulate site-specific axon remodeling in vivo","volume":"95","author":"Wong","year":"2017","journal-title":"Neuron"},{"key":"10.1016\/j.brainres.2018.02.018_b1355","doi-asserted-by":"crossref","first-page":"1020","DOI":"10.1038\/nature03885","article-title":"Local translation of RhoA regulates growth cone collapse","volume":"436","author":"Wu","year":"2005","journal-title":"Nature"},{"key":"10.1016\/j.brainres.2018.02.018_b1360","doi-asserted-by":"crossref","first-page":"8663","DOI":"10.1093\/nar\/gku580","article-title":"Hypermethylated-capped selenoprotein mRNAs in mammals","volume":"42","author":"Wurth","year":"2014","journal-title":"Nucl. Acids Res."},{"key":"10.1016\/j.brainres.2018.02.018_b1365","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/j.mcn.2011.02.013","article-title":"RNA targets of TDP-43 identified by UV-CLIP are deregulated in ALS","volume":"47","author":"Xiao","year":"2011","journal-title":"Mol. Cell Neurosci."},{"key":"10.1016\/j.brainres.2018.02.018_b1370","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1111\/tra.12004","article-title":"mRNA localization: an orchestration of assembly, traffic and synthesis","volume":"14","author":"Xing","year":"2013","journal-title":"Traffic"},{"key":"10.1016\/j.brainres.2018.02.018_b1375","doi-asserted-by":"crossref","first-page":"7778","DOI":"10.1073\/pnas.1219643110","article-title":"Expanded GGGGCC repeat RNA associated with amyotrophic lateral sclerosis and frontotemporal dementia causes neurodegeneration","volume":"110","author":"Xu","year":"2013","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.brainres.2018.02.018_b1380","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1016\/j.celrep.2012.08.025","article-title":"FUS-SMN protein interactions link the motor neuron diseases ALS and SMA","volume":"2","author":"Yamazaki","year":"2012","journal-title":"Cell Rep."},{"key":"10.1016\/j.brainres.2018.02.018_b1385","doi-asserted-by":"crossref","first-page":"1005","DOI":"10.1016\/j.cell.2009.06.023","article-title":"The DLK-1 kinase promotes mRNA stability and local translation in C. elegans synapses and axon regeneration","volume":"138","author":"Yan","year":"2009","journal-title":"Cell"},{"key":"10.1016\/j.brainres.2018.02.018_b1390","doi-asserted-by":"crossref","first-page":"1265","DOI":"10.1038\/nn1773","article-title":"An essential role for beta-actin mRNA localization and translation in Ca2+-dependent growth cone guidance","volume":"9","author":"Yao","year":"2006","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.brainres.2018.02.018_b1395","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1083\/jcb.201306058","article-title":"The RNA-binding protein Fus directs translation of localized mRNAs in APC-RNP granules","volume":"203","author":"Yasuda","year":"2013","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.brainres.2018.02.018_b1400","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1002\/wrna.1352","article-title":"Dysregulated axonal RNA translation in amyotrophic lateral sclerosis","volume":"7","author":"Yasuda","year":"2016","journal-title":"Wiley Interdiscip. Rev. RNA"},{"key":"10.1016\/j.brainres.2018.02.018_b1405","doi-asserted-by":"crossref","first-page":"1015","DOI":"10.1083\/jcb.201608022","article-title":"FUS inclusions disrupt RNA localization by sequestering kinesin-1 and inhibiting microtubule detyrosination","volume":"216","author":"Yasuda","year":"2017","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.brainres.2018.02.018_b1410","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1007\/s10048-009-0200-6","article-title":"Reduced levels of survival motor neuron protein leads to aberrant motoneuron growth in a Xenopus model of muscular atrophy","volume":"11","author":"Ymlahi-Ouazzani","year":"2010","journal-title":"Neurogenetics"},{"key":"10.1016\/j.brainres.2018.02.018_b1415","doi-asserted-by":"crossref","first-page":"792","DOI":"10.1111\/jnc.12266","article-title":"A HuD-ZBP1 ribonucleoprotein complex localizes GAP-43 mRNA into axons through its 3' untranslated region AU-rich regulatory element","volume":"126","author":"Yoo","year":"2013","journal-title":"J. Neurochem."},{"key":"10.1016\/j.brainres.2018.02.018_b1420","doi-asserted-by":"crossref","first-page":"2345","DOI":"10.1016\/j.cub.2006.10.024","article-title":"Myosin-Va facilitates the accumulation of mRNA\/protein complex in dendritic spines","volume":"16","author":"Yoshimura","year":"2006","journal-title":"Curr. Biol."},{"key":"10.1016\/j.brainres.2018.02.018_b1425","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1016\/j.neuron.2016.09.040","article-title":"Presynaptic protein synthesis Is required for long-term plasticity of GABA release","volume":"92","author":"Younts","year":"2016","journal-title":"Neuron"},{"key":"10.1016\/j.brainres.2018.02.018_b1430","article-title":"Dynamic m6A modification regulates local translation of mRNA in axons","author":"Yu","year":"2017","journal-title":"Nucl. Acids Res."},{"key":"10.1016\/j.brainres.2018.02.018_b1435","doi-asserted-by":"crossref","first-page":"22560","DOI":"10.1074\/jbc.M112.357582","article-title":"Neurodegeneration-associated TDP-43 interacts with fragile X mental retardation protein (FMRP)\/Staufen (STAU1) and regulates SIRT1 expression in neuronal cells","volume":"287","author":"Yu","year":"2012","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.brainres.2018.02.018_b1440","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1016\/j.neuron.2008.05.029","article-title":"Localized regulation of axonal RanGTPase controls retrograde injury signaling in peripheral nerve","volume":"59","author":"Yudin","year":"2008","journal-title":"Neuron"},{"key":"10.1016\/j.brainres.2018.02.018_b1445","doi-asserted-by":"crossref","first-page":"283","DOI":"10.3389\/fgene.2012.00283","article-title":"Discovery of novel DENN proteins: implications for the evolution of eukaryotic intracellular membrane structures and human disease","volume":"3","author":"Zhang","year":"2012","journal-title":"Front. Genet."},{"key":"10.1016\/j.brainres.2018.02.018_b1450","doi-asserted-by":"crossref","first-page":"8622","DOI":"10.1523\/JNEUROSCI.3967-05.2006","article-title":"Multiprotein complexes of the survival of motor neuron protein SMN with Gemins traffic to neuronal processes and growth cones of motor neurons","volume":"26","author":"Zhang","year":"2006","journal-title":"J. Neurosci."},{"key":"10.1016\/j.brainres.2018.02.018_b1455","doi-asserted-by":"crossref","first-page":"6627","DOI":"10.1523\/JNEUROSCI.23-16-06627.2003","article-title":"Active transport of the survival motor neuron protein and the role of exon-7 in cytoplasmic localization","volume":"23","author":"Zhang","year":"2003","journal-title":"J. Neurosci."},{"key":"10.1016\/j.brainres.2018.02.018_b1460","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1038\/nature14973","article-title":"The C9orf72 repeat expansion disrupts nucleocytoplasmic transport","volume":"525","author":"Zhang","year":"2015","journal-title":"Nature"},{"key":"10.1016\/j.brainres.2018.02.018_b1465","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1016\/S0896-6273(02)01023-1","article-title":"Localized synaptic potentiation by BDNF requires local protein synthesis in the developing axon","volume":"36","author":"Zhang","year":"2002","journal-title":"Neuron"},{"key":"10.1016\/j.brainres.2018.02.018_b1470","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1016\/j.cell.2008.03.031","article-title":"SMN deficiency causes tissue-specific perturbations in the repertoire of snRNAs and widespread defects in splicing","volume":"133","author":"Zhang","year":"2008","journal-title":"Cell"},{"key":"10.1016\/j.brainres.2018.02.018_b1475","doi-asserted-by":"crossref","first-page":"19348","DOI":"10.1073\/pnas.1319280110","article-title":"Dysregulation of synaptogenesis genes antecedes motor neuron pathology in spinal muscular atrophy","volume":"110","author":"Zhang","year":"2013","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.brainres.2018.02.018_b1480","doi-asserted-by":"crossref","first-page":"1212","DOI":"10.2174\/0929867321666131218093327","article-title":"Neuritin, a neurotrophic factor in nervous system physiology","volume":"21","author":"Zhou","year":"2014","journal-title":"Curr. Med. Chem."},{"key":"10.1016\/j.brainres.2018.02.018_b1485","doi-asserted-by":"crossref","first-page":"15464","DOI":"10.1523\/JNEUROSCI.1800-10.2010","article-title":"Subcellular profiling reveals distinct and developmentally regulated repertoire of growth cone mRNAs","volume":"30","author":"Zivraj","year":"2010","journal-title":"J. Neurosci."},{"key":"10.1016\/j.brainres.2018.02.018_b1490","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1073\/pnas.1013343108","article-title":"Non-ATG-initiated translation directed by microsatellite expansions","volume":"108","author":"Zu","year":"2011","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.brainres.2018.02.018_b1495","doi-asserted-by":"crossref","first-page":"E4968","DOI":"10.1073\/pnas.1315438110","article-title":"RAN proteins and RNA foci from antisense transcripts in C9ORF72 ALS and frontotemporal dementia","volume":"110","author":"Zu","year":"2013","journal-title":"Proc. Natl. Acad. Sci. U.S.A."}],"container-title":["Brain Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006899318300829?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006899318300829?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,13]],"date-time":"2025-09-13T17:59:31Z","timestamp":1757786371000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006899318300829"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,8]]},"references-count":302,"alternative-id":["S0006899318300829"],"URL":"https:\/\/doi.org\/10.1016\/j.brainres.2018.02.018","relation":{},"ISSN":["0006-8993"],"issn-type":[{"value":"0006-8993","type":"print"}],"subject":[],"published":{"date-parts":[[2018,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"mRNP assembly, axonal transport, and local translation in neurodegenerative diseases","name":"articletitle","label":"Article Title"},{"value":"Brain Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.brainres.2018.02.018","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}