{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,17]],"date-time":"2025-10-17T19:57:19Z","timestamp":1760731039440,"version":"3.40.5"},"reference-count":30,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2018,5,1]],"date-time":"2018-05-01T00:00:00Z","timestamp":1525132800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Brain Research"],"published-print":{"date-parts":[[2018,5]]},"DOI":"10.1016\/j.brainres.2018.02.025","type":"journal-article","created":{"date-parts":[[2018,2,21]],"date-time":"2018-02-21T04:56:30Z","timestamp":1519188990000},"page":"55-64","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"special_numbering":"C","title":["Functional relationship between brainstem putative pain-facilitating neurons and spinal nociceptfive neurons during development of inflammation in rats"],"prefix":"10.1016","volume":"1686","author":[{"given":"Rafael","family":"Salas","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karla","family":"Ramirez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Victor","family":"Tortorici","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Horacio","family":"Vanegas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9779-0448","authenticated-orcid":false,"given":"Enrique","family":"Vazquez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.brainres.2018.02.025_b0005","doi-asserted-by":"crossref","first-page":"1210","DOI":"10.1152\/jn.00678.2011","article-title":"Differential modulation of neurons in the rostral ventromedial medulla by neurokinin-1 receptors","volume":"107","author":"Brink","year":"2012","journal-title":"J. Neurophysiol."},{"key":"10.1016\/j.brainres.2018.02.025_b0010","doi-asserted-by":"crossref","first-page":"13222","DOI":"10.1523\/JNEUROSCI.3715-07.2007","article-title":"Sensitization of pain-modulating neurons in the rostral ventromedial medulla after peripheral nerve injury","volume":"27","author":"Carlson","year":"2007","journal-title":"J. Neurosci."},{"key":"10.1016\/j.brainres.2018.02.025_b0015","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1016\/j.pain.2013.02.019","article-title":"Adaptations in responsiveness of brainstem pain-modulating neurons in acute compared with chronic inflammation","volume":"154","author":"Cleary","year":"2013","journal-title":"Pain"},{"key":"10.1016\/j.brainres.2018.02.025_b0020","series-title":"Goodman and Gilman\u2019s The Pharmacological Basis of Therapeutics","first-page":"414","article-title":"Hypnotics and sedatives","author":"Charney","year":"2006"},{"key":"10.1016\/j.brainres.2018.02.025_b0025","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.ejphar.2011.11.034","article-title":"Effects of intra-ventrolateral periaqueductal grey palmitoylethanolamide on thermoceptive threshold and rostral ventromedial medulla cell activity","volume":"676","author":"de Novellis","year":"2012","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.brainres.2018.02.025_b0030","doi-asserted-by":"crossref","first-page":"1726","DOI":"10.1111\/ejn.12942","article-title":"A quantification of the relationship between neuronal responses in the rat rostral ventromedial medulla and noxious stimulation-evoked withdrawal reflexes","volume":"42","author":"Devonshire","year":"2015","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.brainres.2018.02.025_b0035","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1002\/ana.21537","article-title":"Medullary pain facilitating neurons mediate allodynia in headache-related pain","volume":"65","author":"Edelmayer","year":"2009","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.brainres.2018.02.025_b0040","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1038\/nrn1431","article-title":"State-dependent opioid control of pain","volume":"5","author":"Fields","year":"2004","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.brainres.2018.02.025_b0045","doi-asserted-by":"crossref","first-page":"2545","DOI":"10.1523\/JNEUROSCI.03-12-02545.1983","article-title":"The activity of neurons in the rostral medulla of the rat during withdrawal from noxious heat","volume":"3","author":"Fields","year":"1983","journal-title":"J. Neurosci."},{"key":"10.1016\/j.brainres.2018.02.025_b0050","doi-asserted-by":"crossref","first-page":"1742","DOI":"10.1152\/jn.1995.74.4.1742","article-title":"Dorsal horn projection targets of ON and OFF cells in the rostral ventromedial medulla","volume":"74","author":"Fields","year":"1995","journal-title":"J. Neurophysiol."},{"key":"10.1016\/j.brainres.2018.02.025_b0055","doi-asserted-by":"crossref","first-page":"2188","DOI":"10.1111\/j.1460-9568.2007.05832.x","article-title":"Pronociceptive changes in response properties of rostroventromedial medullary neurons in a rat model of neuropathy","volume":"26","author":"Goncalves","year":"2007","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.brainres.2018.02.025_b0060","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/0304-3959(91)90017-R","article-title":"GABA-mediated inhibition in rostral ventromedial medulla: role in nociceptive modulation in the lightly anesthetized rat","volume":"47","author":"Heinricher","year":"1991","journal-title":"Pain"},{"key":"10.1016\/j.brainres.2018.02.025_b0065","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1016\/0306-4522(94)90022-1","article-title":"Disinhibition of off-cells and antinociception produced by an opioid action within the rostral ventromedial medulla","volume":"63","author":"Heinricher","year":"1994","journal-title":"Neuroscience"},{"key":"10.1016\/j.brainres.2018.02.025_b0070","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1016\/0306-4522(94)90548-7","article-title":"Interference with GABA transmission in the rostral ventromedial medulla: disinhibition of off-cells as a central mechanism in nociceptive modulation","volume":"63","author":"Heinricher","year":"1994","journal-title":"Neuroscience"},{"key":"10.1016\/j.brainres.2018.02.025_b0075","first-page":"251","article-title":"Descending modulation after injury","volume":"24","author":"Heinricher","year":"2003","journal-title":"Prog. Pain Res. Mngmnt."},{"key":"10.1016\/j.brainres.2018.02.025_b0080","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/0304-3959(89)90009-2","article-title":"Medullary on- and off-cell responses precede both segmental and thalamic responses to tail heating","volume":"39","author":"Hernandez","year":"1989","journal-title":"Pain"},{"key":"10.1016\/j.brainres.2018.02.025_b0085","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1016\/S0304-3959(00)00452-8","article-title":"Encoding of noxious stimulus intensity by putative pain modulating neurons in the rostral ventromedial medulla and by simultaneously recorded nociceptive neurons in the spinal dorsal horn of rats","volume":"91","author":"Hernandez","year":"2001","journal-title":"Pain"},{"key":"10.1016\/j.brainres.2018.02.025_b0090","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/j.neuroscience.2012.08.029","article-title":"Changes in response properties of rostral ventromedial medulla neurons during prolonged inflammation: modulation by neurokinin-1 receptors","volume":"224","author":"Khasabov","year":"2012","journal-title":"Neuroscience"},{"key":"10.1016\/j.brainres.2018.02.025_b0095","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/j.neuroscience.2013.06.057","article-title":"Loss of neurons in rostral ventromedial medulla that express neurokinin-1 receptors decreases the development of hyperalgesia","volume":"250","author":"Khasabov","year":"2013","journal-title":"Neuroscience"},{"key":"10.1016\/j.brainres.2018.02.025_b0100","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1152\/jn.00449.2005","article-title":"Role for medullary pain facilitating neurons in secondary thermal hyperalgesia","volume":"95","author":"Kincaid","year":"2006","journal-title":"J. Neurophysiol."},{"key":"10.1016\/j.brainres.2018.02.025_b0105","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1097\/01.j.pain.0000460311.71572.5f","article-title":"Selective melatonin MT2 receptor ligands relieve neuropathic pain through modulation of brainstem descending antinociceptive pathways","volume":"156","author":"Lopez-Canul","year":"2015","journal-title":"Pain"},{"key":"10.1016\/j.brainres.2018.02.025_b0110","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.pain.2008.02.032","article-title":"NK-1 receptors in the rostral ventromedial medulla contribute to hyperalgesia produced by intraplantar injection of capsaicin","volume":"139","author":"Pacharinsak","year":"2008","journal-title":"Pain"},{"key":"10.1016\/j.brainres.2018.02.025_b0115","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1186\/1744-8069-9-44","article-title":"Effects of a metabotropic glutamate receptor subtype 7 negative allosteric modulator in the periaqueductal grey on pain responses and rostral ventromedial medulla cell activity in rat","volume":"9","author":"Palazzo","year":"2013","journal-title":"Mol. Pain"},{"year":"1998","series-title":"The Rat Brain in Stereotaxic Coordinates","author":"Paxinos","key":"10.1016\/j.brainres.2018.02.025_b0120"},{"key":"10.1016\/j.brainres.2018.02.025_b0125","doi-asserted-by":"crossref","first-page":"5281","DOI":"10.1523\/JNEUROSCI.21-14-05281.2001","article-title":"Inhibition of neuropathic pain by selective ablation of brainstem medullary cells expressing the \u03bc-opioid receptor","volume":"21","author":"Porreca","year":"2001","journal-title":"J. Neurosci."},{"key":"10.1016\/j.brainres.2018.02.025_b0130","doi-asserted-by":"crossref","first-page":"2196","DOI":"10.1152\/jn.00212.2013","article-title":"Dorsal striatum metabotropic glutamate receptor 8 affects nocifensive responses and rostral ventromedial medulla cell activity in neuropathic pain conditions","volume":"111","author":"Rossi","year":"2014","journal-title":"J Neurophysiol."},{"key":"10.1016\/j.brainres.2018.02.025_b0135","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.brainres.2016.10.001","article-title":"Activity correlation between on-like and off-like cells of the rostral ventromedial medulla and simultaneously recorded wide-dynamic-range neurons of the spinal dorsal horn in rats","volume":"1652","author":"Salas","year":"2016","journal-title":"Brain Res."},{"key":"10.1016\/j.brainres.2018.02.025_b0140","article-title":"Role of RVM neurons in capsaicin-evoked visceral nociception","volume":"14","author":"Sanoja","year":"2009","journal-title":"Eur. J. Pain"},{"key":"10.1016\/j.brainres.2018.02.025_b0145","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/0006-8993(84)90689-9","article-title":"Tail-flick related activity in medullospinal neurons","volume":"321","author":"Vanegas","year":"1984","journal-title":"Brain Res."},{"key":"10.1016\/j.brainres.2018.02.025_b0150","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/j.pain.2006.08.020","article-title":"NMDA receptor-mediated activation of medullary pro-nociceptive neurons is required for secondary thermal hyperalgesia","volume":"127","author":"Xu","year":"2007","journal-title":"Pain"}],"container-title":["Brain Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006899318300957?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006899318300957?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,10,11]],"date-time":"2019-10-11T04:21:00Z","timestamp":1570767660000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006899318300957"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,5]]},"references-count":30,"alternative-id":["S0006899318300957"],"URL":"https:\/\/doi.org\/10.1016\/j.brainres.2018.02.025","relation":{},"ISSN":["0006-8993"],"issn-type":[{"type":"print","value":"0006-8993"}],"subject":[],"published":{"date-parts":[[2018,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Functional relationship between brainstem putative pain-facilitating neurons and spinal nociceptfive neurons during development of inflammation in rats","name":"articletitle","label":"Article Title"},{"value":"Brain Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.brainres.2018.02.025","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}