{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,5]],"date-time":"2026-01-05T21:56:54Z","timestamp":1767650214148,"version":"3.41.0"},"reference-count":97,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,1,1]],"date-time":"2019-01-01T00:00:00Z","timestamp":1546300800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Brain Research"],"published-print":{"date-parts":[[2019,1]]},"DOI":"10.1016\/j.brainres.2018.03.009","type":"journal-article","created":{"date-parts":[[2018,3,22]],"date-time":"2018-03-22T06:58:05Z","timestamp":1521701885000},"page":"46-53","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":8,"special_numbering":"C","title":["Amyloid beta peptides, locus coeruleus-norepinephrine system and dense core vesicles"],"prefix":"10.1016","volume":"1702","author":[{"given":"Jennifer A.","family":"Ross","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Beverly A.S.","family":"Reyes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elisabeth J.","family":"Van Bockstaele","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"12","key":"10.1016\/j.brainres.2018.03.009_b0005","doi-asserted-by":"crossref","first-page":"1567","DOI":"10.1038\/nn.2433","article-title":"Amyloid-beta as a positive endogenous regulator of release probability at hippocampal synapses","volume":"12","author":"Abramov","year":"2009","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.brainres.2018.03.009_b0010","unstructured":"Aixa Alfonso, G.S.P., Julie Donaldson, 2010. Dense Core Secretory Granule Formation. Trafficking Inside Cells: Pathways, Mechanisms and Regulation. N. Segev, Springer Science & Business Media, p. 445."},{"issue":"3","key":"10.1016\/j.brainres.2018.03.009_b0015","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1093\/cercor\/8.3.269","article-title":"Cellular and subcellular sites for noradrenergic action in the monkey dorsolateral prefrontal cortex as revealed by the immunocytochemical localization of noradrenergic receptors and axons","volume":"8","author":"Aoki","year":"1998","journal-title":"Cereb. Cortex"},{"key":"10.1016\/j.brainres.2018.03.009_b0020","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1016\/S1054-3589(08)60862-5","article-title":"Noradrenergic modulation of the prefrontal cortex as revealed by electron microscopic immunocytochemistry","volume":"42","author":"Aoki","year":"1998","journal-title":"Adv. Pharmacol."},{"issue":"1","key":"10.1016\/j.brainres.2018.03.009_b0025","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1002\/cne.20723","article-title":"Adaptive gain and the role of the locus coeruleus-norepinephrine system in optimal performance","volume":"493","author":"Aston-Jones","year":"2005","journal-title":"J. Comp. Neurol."},{"issue":"9","key":"10.1016\/j.brainres.2018.03.009_b0030","doi-asserted-by":"crossref","first-page":"630","DOI":"10.1096\/fasebj.8.9.8005390","article-title":"Peptide secretion: what do we know?","volume":"8","author":"Bean","year":"1994","journal-title":"FASEB J."},{"issue":"20","key":"10.1016\/j.brainres.2018.03.009_b0035","doi-asserted-by":"crossref","first-page":"1699","DOI":"10.1212\/WNL.0b013e3181c2937c","article-title":"The locus ceruleus norepinephrine system: functional organization and potential clinical significance","volume":"73","author":"Benarroch","year":"2009","journal-title":"Neurology"},{"issue":"1","key":"10.1016\/j.brainres.2018.03.009_b0040","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/S0165-0173(03)00143-7","article-title":"The locus coeruleus-noradrenergic system: modulation of behavioral state and state-dependent cognitive processes","volume":"42","author":"Berridge","year":"2003","journal-title":"Brain Res. Brain Res. Rev."},{"issue":"1","key":"10.1016\/j.brainres.2018.03.009_b0045","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/0006-8993(91)90697-T","article-title":"Synaptophysin and chromogranin A immunoreactivities in senile plaques of Alzheimer's disease","volume":"539","author":"Brion","year":"1991","journal-title":"Brain Res."},{"issue":"5","key":"10.1016\/j.brainres.2018.03.009_b0050","doi-asserted-by":"crossref","first-page":"2092","DOI":"10.1073\/pnas.90.5.2092","article-title":"Generation of beta-amyloid in the secretory pathway in neuronal and nonneuronal cells","volume":"90","author":"Busciglio","year":"1993","journal-title":"Proc. Natl. Acad. Sci. USA"},{"issue":"1","key":"10.1016\/j.brainres.2018.03.009_b0055","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/S0014-2999(98)00889-9","article-title":"Alpha2A- but not alpha2B\/C-adrenoceptors modulate noradrenaline release in rat locus coeruleus: voltammetric data","volume":"366","author":"Callado","year":"1999","journal-title":"Eur. J. Pharmacol."},{"issue":"6","key":"10.1016\/j.brainres.2018.03.009_b0060","doi-asserted-by":"crossref","first-page":"2350","DOI":"10.1046\/j.1471-4159.2000.0742350.x","article-title":"Spatiotemporal interaction of alpha(2) autoreceptors and noradrenaline transporters in the rat locus coeruleus: implications for volume transmission","volume":"74","author":"Callado","year":"2000","journal-title":"J. Neurochem."},{"issue":"2","key":"10.1016\/j.brainres.2018.03.009_b0065","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1038\/scientificamerican0885-40","article-title":"The adrenal chromaffin cell","volume":"253","author":"Carmichael","year":"1985","journal-title":"Sci. Am."},{"issue":"1","key":"10.1016\/j.brainres.2018.03.009_b0070","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/j.neuron.2008.02.003","article-title":"Endocytosis is required for synaptic activity-dependent release of amyloid-beta in vivo","volume":"58","author":"Cirrito","year":"2008","journal-title":"Neuron"},{"issue":"6","key":"10.1016\/j.brainres.2018.03.009_b0075","doi-asserted-by":"crossref","first-page":"913","DOI":"10.1016\/j.neuron.2005.10.028","article-title":"Synaptic activity regulates interstitial fluid amyloid-beta levels in vivo","volume":"48","author":"Cirrito","year":"2005","journal-title":"Neuron"},{"issue":"11","key":"10.1016\/j.brainres.2018.03.009_b0080","doi-asserted-by":"crossref","first-page":"981","DOI":"10.1001\/archpsyc.56.11.981","article-title":"Neuropeptide abnormalities in patients with early Alzheimer disease","volume":"56","author":"Davis","year":"1999","journal-title":"Arch. Gen. Psychiatry"},{"issue":"2","key":"10.1016\/j.brainres.2018.03.009_b0085","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/0006-8993(77)90759-4","article-title":"Noradrenergic axon terminals in the cerebral cortex of rat. III. Topometric ultrastructural analysis","volume":"133","author":"Descarries","year":"1977","journal-title":"Brain Res."},{"issue":"35","key":"10.1016\/j.brainres.2018.03.009_b0090","doi-asserted-by":"crossref","first-page":"11235","DOI":"10.1523\/JNEUROSCI.23-35-11235.2003","article-title":"Control of secretion by temporal patterns of action potentials in adrenal chromaffin cells","volume":"23","author":"Duan","year":"2003","journal-title":"J. Neurosci."},{"issue":"17","key":"10.1016\/j.brainres.2018.03.009_b0095","doi-asserted-by":"crossref","first-page":"1645","DOI":"10.2174\/156802607782341037","article-title":"Relevance of neuropeptide Y (NPY) in psychiatry","volume":"7","author":"Eaton","year":"2007","journal-title":"Curr. Top. Med. Chem."},{"key":"10.1016\/j.brainres.2018.03.009_b0100","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.ynstr.2014.09.007","article-title":"Targeting the Neuropeptide Y System in Stress-related Psychiatric Disorders","volume":"1","author":"Enman","year":"2015","journal-title":"Neurobiol. Stress"},{"issue":"5","key":"10.1016\/j.brainres.2018.03.009_b0105","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1016\/S0197-0186(02)00049-9","article-title":"Noradrenergic regulation of inflammatory gene expression in brain","volume":"41","author":"Feinstein","year":"2002","journal-title":"Neurochem. Int."},{"issue":"Suppl 2","key":"10.1016\/j.brainres.2018.03.009_b0110","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1111\/jnc.13447","article-title":"Causes, consequences, and cures for neuroinflammation mediated via the locus coeruleus: noradrenergic signaling system","volume":"139","author":"Feinstein","year":"2016","journal-title":"J. Neurochem."},{"issue":"1","key":"10.1016\/j.brainres.2018.03.009_b0115","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1111\/j.1471-4159.1986.tb02865.x","article-title":"Chromogranin C: a third component of the acidic proteins in chromaffin granules","volume":"47","author":"Fischer-Colbrie","year":"1986","journal-title":"J. Neurochem."},{"key":"10.1016\/j.brainres.2018.03.009_b0120","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1111\/j.1749-6632.1987.tb27189.x","article-title":"Chromogranins A, B, and C: widespread constituents of secretory vesicles","volume":"493","author":"Fischer-Colbrie","year":"1987","journal-title":"Ann. N Y Acad. Sci."},{"issue":"1","key":"10.1016\/j.brainres.2018.03.009_b0125","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1111\/j.1471-4159.1987.tb13157.x","article-title":"Isolation and characterization of chromogranins A, B, and C from bovine chromaffin granules and a rat pheochromocytoma","volume":"48","author":"Fischer-Colbrie","year":"1987","journal-title":"J. Neurochem."},{"issue":"6","key":"10.1016\/j.brainres.2018.03.009_b0130","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1016\/S0092-8674(88)91131-2","article-title":"Multiple neuropeptides derived from a common precursor are differentially packaged and transported","volume":"54","author":"Fisher","year":"1988","journal-title":"Cell"},{"issue":"32","key":"10.1016\/j.brainres.2018.03.009_b0135","doi-asserted-by":"crossref","first-page":"7324","DOI":"10.1523\/JNEUROSCI.2042-05.2005","article-title":"Activity-dependent differential transmitter release in mouse adrenal chromaffin cells","volume":"25","author":"Fulop","year":"2005","journal-title":"J. Neurosci."},{"key":"10.1016\/j.brainres.2018.03.009_b0140","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1007\/0-306-46837-9_3","article-title":"Signal-mediated sorting of chromogranins to secretory granules","volume":"482","author":"Gerdes","year":"2000","journal-title":"Adv. Exp. Med. Biol."},{"issue":"20","key":"10.1016\/j.brainres.2018.03.009_b0145","doi-asserted-by":"crossref","first-page":"12009","DOI":"10.1016\/S0021-9258(18)80167-3","article-title":"The primary structure of human secretogranin II, a widespread tyrosine-sulfated secretory granule protein that exhibits low pH- and calcium-induced aggregation","volume":"264","author":"Gerdes","year":"1989","journal-title":"J. Biol. Chem."},{"issue":"4","key":"10.1016\/j.brainres.2018.03.009_b0150","doi-asserted-by":"crossref","first-page":"853","DOI":"10.1002\/cne.901930403","article-title":"Monoaminergic presynaptic axons and dendrites in rat locus coeruleus seen in reconstructions of serial sections","volume":"193","author":"Groves","year":"1980","journal-title":"J. Comp. Neurol."},{"issue":"10","key":"10.1016\/j.brainres.2018.03.009_b0155","doi-asserted-by":"crossref","first-page":"5065","DOI":"10.1021\/pr100358b","article-title":"Mass spectrometry-based neuropeptidomics of secretory vesicles from human adrenal medullary pheochromocytoma reveals novel peptide products of prohormone processing","volume":"9","author":"Gupta","year":"2010","journal-title":"J. Proteome Res."},{"issue":"5","key":"10.1016\/j.brainres.2018.03.009_b0160","doi-asserted-by":"crossref","first-page":"a006270","DOI":"10.1101\/cshperspect.a006270","article-title":"Trafficking and proteolytic processing of APP","volume":"2","author":"Haass","year":"2012","journal-title":"Cold Spring Harb. Perspect. Med."},{"issue":"6393","key":"10.1016\/j.brainres.2018.03.009_b0165","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1038\/359322a0","article-title":"Amyloid beta-peptide is produced by cultured cells during normal metabolism","volume":"359","author":"Haass","year":"1992","journal-title":"Nature"},{"issue":"2","key":"10.1016\/j.brainres.2018.03.009_b0170","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/0166-2236(94)90079-5","article-title":"Corticotropin-releasing factor and neuropeptide Y: role in emotional integration","volume":"17","author":"Heilig","year":"1994","journal-title":"Trends Neurosci."},{"issue":"1","key":"10.1016\/j.brainres.2018.03.009_b0175","first-page":"47","article-title":"Chromogranin A","volume":"18","author":"Hendy","year":"1995","journal-title":"Clin. Invest Med."},{"issue":"7","key":"10.1016\/j.brainres.2018.03.009_b0180","doi-asserted-by":"crossref","first-page":"2434","DOI":"10.1523\/JNEUROSCI.22-07-02434.2002","article-title":"Noradrenergic depletion potentiates beta -amyloid-induced cortical inflammation: implications for Alzheimer's disease","volume":"22","author":"Heneka","year":"2002","journal-title":"J. Neurosci."},{"issue":"1","key":"10.1016\/j.brainres.2018.03.009_b0185","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1007\/BF00335247","article-title":"On the ultrastructural localization of noradrenaline in the central nervous system of the rat","volume":"79","author":"Hokfelt","year":"1967","journal-title":"Z Zellforsch Mikrosk Anat"},{"issue":"1","key":"10.1016\/j.brainres.2018.03.009_b0190","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/BF00336984","article-title":"In vitro studies on central and peripheral monoamine neurons at the ultrastructural level","volume":"91","author":"Hokfelt","year":"1968","journal-title":"Z Zellforsch Mikrosk Anat"},{"issue":"8","key":"10.1016\/j.brainres.2018.03.009_b0195","doi-asserted-by":"crossref","first-page":"1337","DOI":"10.1016\/S0028-3908(00)00010-1","article-title":"Neuropeptides\u2013an overview","volume":"39","author":"Hokfelt","year":"2000","journal-title":"Neuropharmacology"},{"issue":"3","key":"10.1016\/j.brainres.2018.03.009_b0200","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1179\/1743132813Y.0000000288","article-title":"Relationship between amyloid-beta and the ubiquitin-proteasome system in Alzheimer's disease","volume":"36","author":"Hong","year":"2014","journal-title":"Neurol. Res."},{"issue":"4","key":"10.1016\/j.brainres.2018.03.009_b0205","doi-asserted-by":"crossref","first-page":"1401","DOI":"10.1073\/pnas.0608897104","article-title":"Long latency of evoked quantal transmitter release from somata of locus coeruleus neurons in rat pontine slices","volume":"104","author":"Huang","year":"2007","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.brainres.2018.03.009_b0210","doi-asserted-by":"crossref","first-page":"29","DOI":"10.3389\/fnmol.2012.00029","article-title":"Physiology of quantal norepinephrine release from somatodendritic sites of neurons in locus coeruleus","volume":"5","author":"Huang","year":"2012","journal-title":"Front. Mol. Neurosci."},{"issue":"1","key":"10.1016\/j.brainres.2018.03.009_b0215","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/0968-0004(91)90012-K","article-title":"The granin (chromogranin\/secretogranin) family","volume":"16","author":"Huttner","year":"1991","journal-title":"Trends Biochem. Sci."},{"issue":"10","key":"10.1016\/j.brainres.2018.03.009_b0220","doi-asserted-by":"crossref","first-page":"e26540","DOI":"10.1371\/journal.pone.0026540","article-title":"Peptide fingerprinting of Alzheimer's disease in cerebrospinal fluid: identification and prospective evaluation of new synaptic biomarkers","volume":"6","author":"Jahn","year":"2011","journal-title":"PLoS One"},{"key":"10.1016\/j.brainres.2018.03.009_b0225","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1186\/1471-2202-11-33","article-title":"Interaction of the mu-opioid receptor with GPR177 (Wntless) inhibits Wnt secretion: potential implications for opioid dependence","volume":"11","author":"Jin","year":"2010","journal-title":"BMC Neurosci."},{"issue":"6","key":"10.1016\/j.brainres.2018.03.009_b0230","doi-asserted-by":"crossref","first-page":"925","DOI":"10.1016\/S0896-6273(03)00124-7","article-title":"APP processing and synaptic function","volume":"37","author":"Kamenetz","year":"2003","journal-title":"Neuron"},{"issue":"3","key":"10.1016\/j.brainres.2018.03.009_b0235","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1016\/S0149-7634(01)00066-5","article-title":"The neurocircuitry and receptor subtypes mediating anxiolytic-like effects of neuropeptide Y","volume":"26","author":"Kask","year":"2002","journal-title":"Neurosci. Biobehav. Rev."},{"key":"10.1016\/j.brainres.2018.03.009_b0240","first-page":"124","article-title":"Dense-core secretory granule biogenesis","volume":"21","author":"Kim","year":"2006","journal-title":"Physiology (Bethesda)"},{"issue":"4","key":"10.1016\/j.brainres.2018.03.009_b0245","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1016\/S0092-8674(01)00459-7","article-title":"Chromogranin A, an \u201con\/off\u201d switch controlling dense-core secretory granule biogenesis","volume":"106","author":"Kim","year":"2001","journal-title":"Cell"},{"key":"10.1016\/j.brainres.2018.03.009_b0250","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1111\/j.1749-6632.2002.tb04487.x","article-title":"Large dense-core secretory granule biogenesis is under the control of chromogranin A in neuroendocrine cells","volume":"971","author":"Kim","year":"2002","journal-title":"Ann. N Y Acad. Sci."},{"issue":"42","key":"10.1016\/j.brainres.2018.03.009_b0255","doi-asserted-by":"crossref","first-page":"41182","DOI":"10.1074\/jbc.M306403200","article-title":"The intracellular domain of the low density lipoprotein receptor-related protein modulates transactivation mediated by amyloid precursor protein and Fe65","volume":"278","author":"Kinoshita","year":"2003","journal-title":"J. Biol. Chem."},{"issue":"35","key":"10.1016\/j.brainres.2018.03.009_b0260","doi-asserted-by":"crossref","first-page":"11848","DOI":"10.1523\/JNEUROSCI.2985-10.2010","article-title":"Norepinephrine promotes microglia to uptake and degrade amyloid beta peptide through upregulation of mouse formyl peptide receptor 2 and induction of insulin-degrading enzyme","volume":"30","author":"Kong","year":"2010","journal-title":"J. Neurosci."},{"issue":"7","key":"10.1016\/j.brainres.2018.03.009_b0265","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1038\/nrn2168","article-title":"Intracellular amyloid-beta in Alzheimer's disease","volume":"8","author":"LaFerla","year":"2007","journal-title":"Nat. Rev. Neurosci."},{"issue":"1","key":"10.1016\/j.brainres.2018.03.009_b0270","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/0306-4522(92)90003-K","article-title":"Synaptic pathology in Alzheimer's disease: immunological data for markers of synaptic and large dense-core vesicles","volume":"46","author":"Lassmann","year":"1992","journal-title":"Neuroscience"},{"issue":"1","key":"10.1016\/j.brainres.2018.03.009_b0275","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.exger.2003.09.018","article-title":"Chromogranin peptides in Alzheimer's disease","volume":"39","author":"Lechner","year":"2004","journal-title":"Exp. Gerontol."},{"issue":"6","key":"10.1016\/j.brainres.2018.03.009_b0280","doi-asserted-by":"crossref","first-page":"788","DOI":"10.1016\/j.neuron.2009.05.012","article-title":"Soluble oligomers of amyloid Beta protein facilitate hippocampal long-term depression by disrupting neuronal glutamate uptake","volume":"62","author":"Li","year":"2009","journal-title":"Neuron"},{"issue":"1\u20132","key":"10.1016\/j.brainres.2018.03.009_b0285","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1385\/JMN:22:1-2:63","article-title":"Secretory granule biogenesis and neuropeptide sorting to the regulated secretory pathway in neuroendocrine cells","volume":"22","author":"Loh","year":"2004","journal-title":"J. Mol. Neurosci."},{"issue":"2","key":"10.1016\/j.brainres.2018.03.009_b0290","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1038\/nrn1845","article-title":"Dendritic peptide release and peptide-dependent behaviours","volume":"7","author":"Ludwig","year":"2006","journal-title":"Nat. Rev. Neurosci."},{"issue":"1\u20132","key":"10.1016\/j.brainres.2018.03.009_b0295","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1385\/JMN:18:1-2:53","article-title":"Synaptic proteins in Alzheimer's disease","volume":"18","author":"Marksteiner","year":"2002","journal-title":"J. Mol. Neurosci."},{"issue":"1","key":"10.1016\/j.brainres.2018.03.009_b0300","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1002\/jnr.490320105","article-title":"beta-Amyloid precursor protein of Alzheimer's disease in cultured bovine oligodendrocytes","volume":"32","author":"Mizuguchi","year":"1992","journal-title":"J. Neurosci. Res."},{"issue":"4","key":"10.1016\/j.brainres.2018.03.009_b0305","first-page":"235","article-title":"The chromaffin vesicle: a model secretory organelle","volume":"28","author":"Njus","year":"1985","journal-title":"Physiologist"},{"issue":"1","key":"10.1016\/j.brainres.2018.03.009_b0310","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1007\/s12017-009-8097-7","article-title":"Synaptic depression and aberrant excitatory network activity in Alzheimer's disease: two faces of the same coin?","volume":"12","author":"Palop","year":"2010","journal-title":"Neuromolecular Med."},{"issue":"29","key":"10.1016\/j.brainres.2018.03.009_b0315","doi-asserted-by":"crossref","first-page":"19936","DOI":"10.1074\/jbc.M800732200","article-title":"Prothyrotropin-releasing hormone targets its processing products to different vesicles of the secretory pathway","volume":"283","author":"Perello","year":"2008","journal-title":"J. Biol. Chem."},{"issue":"1","key":"10.1016\/j.brainres.2018.03.009_b0320","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/0306-4522(93)90189-M","article-title":"Evidence for nonsynaptic serotonergic and noradrenergic innervation of the rat dorsal horn and possible involvement of neuron-glia interactions","volume":"52","author":"Ridet","year":"1993","journal-title":"Neuroscience"},{"key":"10.1016\/j.brainres.2018.03.009_b0325","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/j.ynstr.2015.09.002","article-title":"Locus Coeruleus, norepinephrine and Abeta peptides in Alzheimer's disease","volume":"2","author":"Ross","year":"2015","journal-title":"Neurobiol. Stress"},{"issue":"6","key":"10.1016\/j.brainres.2018.03.009_b0330","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1038\/mp.2012.101","article-title":"Neuropeptide Y and posttraumatic stress disorder","volume":"18","author":"Sah","year":"2013","journal-title":"Mol. Psychiatry"},{"issue":"4","key":"10.1016\/j.brainres.2018.03.009_b0335","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/j.npep.2004.05.006","article-title":"Interactions between NPY and CRF in the amygdala to regulate emotionality","volume":"38","author":"Sajdyk","year":"2004","journal-title":"Neuropeptides"},{"issue":"2","key":"10.1016\/j.brainres.2018.03.009_b0340","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1007\/s00441-006-0268-3","article-title":"Neuropeptides as synaptic transmitters","volume":"326","author":"Salio","year":"2006","journal-title":"Cell Tissue Res."},{"issue":"6393","key":"10.1016\/j.brainres.2018.03.009_b0345","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1038\/359325a0","article-title":"Isolation and quantification of soluble Alzheimer's beta-peptide from biological fluids","volume":"359","author":"Seubert","year":"1992","journal-title":"Nature"},{"issue":"4","key":"10.1016\/j.brainres.2018.03.009_b0350","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1080\/10253890500504557","article-title":"Role of stress, corticotrophin releasing factor (CRF) and amygdala plasticity in chronic anxiety","volume":"8","author":"Shekhar","year":"2005","journal-title":"Stress"},{"issue":"1","key":"10.1016\/j.brainres.2018.03.009_b0355","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1007\/BF01474260","article-title":"The fine structural organization of the locus coeruleus in the rat with reference to noradrenaline contents","volume":"37","author":"Shimizu","year":"1979","journal-title":"Exp. Brain Res."},{"issue":"5079","key":"10.1016\/j.brainres.2018.03.009_b0360","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1126\/science.1439760","article-title":"Production of the Alzheimer amyloid beta protein by normal proteolytic processing","volume":"258","author":"Shoji","year":"1992","journal-title":"Science"},{"issue":"8","key":"10.1016\/j.brainres.2018.03.009_b0365","doi-asserted-by":"crossref","first-page":"1051","DOI":"10.1038\/nn1503","article-title":"Regulation of NMDA receptor trafficking by amyloid-beta","volume":"8","author":"Snyder","year":"2005","journal-title":"Nat. Neurosci."},{"issue":"12","key":"10.1016\/j.brainres.2018.03.009_b0370","doi-asserted-by":"crossref","first-page":"4845","DOI":"10.1073\/pnas.87.12.4845","article-title":"Dale's hypothesis revisited: different neuropeptides derived from a common prohormone are targeted to different processes","volume":"87","author":"Sossin","year":"1990","journal-title":"Proc. Natl. Acad. Sci. USA"},{"issue":"4","key":"10.1016\/j.brainres.2018.03.009_b0375","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1002\/ana.410300410","article-title":"Physical basis of cognitive alterations in Alzheimer's disease: synapse loss is the major correlate of cognitive impairment","volume":"30","author":"Terry","year":"1991","journal-title":"Ann. Neurol."},{"issue":"2","key":"10.1016\/j.brainres.2018.03.009_b0380","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1038\/nrn2977","article-title":"The role of G protein-coupled receptors in the pathology of Alzheimer's disease","volume":"12","author":"Thathiah","year":"2011","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.brainres.2018.03.009_b0385","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1016\/j.peptides.2013.04.020","article-title":"Beta-amyloid peptides undergo regulated co-secretion with neuropeptide and catecholamine neurotransmitters","volume":"46","author":"Toneff","year":"2013","journal-title":"Peptides"},{"key":"10.1016\/j.brainres.2018.03.009_b0390","doi-asserted-by":"crossref","first-page":"319","DOI":"10.3389\/fphys.2012.00319","article-title":"Extrasynaptic exocytosis and its mechanisms: a source of molecules mediating volume transmission in the nervous system","volume":"3","author":"Trueta","year":"2012","journal-title":"Front. Physiol."},{"issue":"24","key":"10.1016\/j.brainres.2018.03.009_b0395","doi-asserted-by":"crossref","first-page":"9205","DOI":"10.1523\/JNEUROSCI.0950-15.2015","article-title":"Amyloid-beta Impairs Synaptic Inhibition via GABA(A) Receptor Endocytosis","volume":"35","author":"Ulrich","year":"2015","journal-title":"J. Neurosci."},{"issue":"6","key":"10.1016\/j.brainres.2018.03.009_b0400","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1002\/hipo.450050611","article-title":"Relational features of acetylcholine, noradrenaline, serotonin and GABA axon terminals in the stratum radiatum of adult rat hippocampus (CA1)","volume":"5","author":"Umbriaco","year":"1995","journal-title":"Hippocampus"},{"issue":"2\u20133","key":"10.1016\/j.brainres.2018.03.009_b0405","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1016\/j.ejphar.2007.11.062","article-title":"Convergent regulation of locus coeruleus activity as an adaptive response to stress","volume":"583","author":"Valentino","year":"2008","journal-title":"Eur. J. Pharmacol."},{"issue":"3","key":"10.1016\/j.brainres.2018.03.009_b0410","doi-asserted-by":"crossref","first-page":"1178","DOI":"10.1016\/S0022-3565(25)24614-6","article-title":"Morphine effects on locus ceruleus neurons are dependent on the state of arousal and availability of external stimuli: studies in anesthetized and unanesthetized rats","volume":"244","author":"Valentino","year":"1988","journal-title":"J. Pharmacol. Exp. Ther."},{"issue":"3","key":"10.1016\/j.brainres.2018.03.009_b0415","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1002\/(SICI)1096-9861(19960115)364:3<523::AID-CNE10>3.0.CO;2-Q","article-title":"Corticotropin-releasing factor-containing axon terminals synapse onto catecholamine dendrites and may presynaptically modulate other afferents in the rostral pole of the nucleus locus coeruleus in the rat brain","volume":"364","author":"Van Bockstaele","year":"1996","journal-title":"J. Comp. Neurol."},{"issue":"10","key":"10.1016\/j.brainres.2018.03.009_b0420","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1046\/j.1365-2826.1998.00254.x","article-title":"Amygdaloid corticotropin-releasing factor targets locus coeruleus dendrites: substrate for the co-ordination of emotional and cognitive limbs of the stress response","volume":"10","author":"Van Bockstaele","year":"1998","journal-title":"J. Neuroendocrinol."},{"issue":"5440","key":"10.1016\/j.brainres.2018.03.009_b0425","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1126\/science.286.5440.735","article-title":"Beta-secretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic protease BACE","volume":"286","author":"Vassar","year":"1999","journal-title":"Science"},{"issue":"36","key":"10.1016\/j.brainres.2018.03.009_b0430","doi-asserted-by":"crossref","first-page":"31852","DOI":"10.1074\/jbc.M111.244335","article-title":"Amyloid beta peptide-(1\u201342) induces internalization and degradation of beta2 adrenergic receptors in prefrontal cortical neurons","volume":"286","author":"Wang","year":"2011","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.brainres.2018.03.009_b0435","doi-asserted-by":"crossref","unstructured":"Wang, Z.-W., ebrary Inc., 2008. Molecular Mechanisms of Neurotransmitter Rlease.","DOI":"10.1007\/978-1-59745-481-0"},{"issue":"10","key":"10.1016\/j.brainres.2018.03.009_b0440","doi-asserted-by":"crossref","first-page":"5002","DOI":"10.1021\/pr1003104","article-title":"Proteomics of dense core secretory vesicles reveal distinct protein categories for secretion of neuroeffectors for cell-cell communication","volume":"9","author":"Wegrzyn","year":"2010","journal-title":"J Proteome Res."},{"issue":"20","key":"10.1016\/j.brainres.2018.03.009_b0445","doi-asserted-by":"crossref","first-page":"9513","DOI":"10.1073\/pnas.90.20.9513","article-title":"Human neurons derived from a teratocarcinoma cell line express solely the 695-amino acid amyloid precursor protein and produce intracellular beta-amyloid or A4 peptides","volume":"90","author":"Wertkin","year":"1993","journal-title":"Proc. Natl. Acad. Sci. USA"},{"issue":"24","key":"10.1016\/j.brainres.2018.03.009_b0450","doi-asserted-by":"crossref","first-page":"6637","DOI":"10.1523\/JNEUROSCI.5100-05.2006","article-title":"Near simultaneous release of classical and peptide cotransmitters from chromaffin cells","volume":"26","author":"Whim","year":"2006","journal-title":"J. Neurosci."},{"key":"10.1016\/j.brainres.2018.03.009_b0455","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1186\/1750-1326-9-22","article-title":"Identification of longitudinally dynamic biomarkers in Alzheimer's disease cerebrospinal fluid by targeted proteomics","volume":"9","author":"Wildsmith","year":"2014","journal-title":"Mol. Neurodegener."},{"issue":"1","key":"10.1016\/j.brainres.2018.03.009_b0460","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/0306-4522(85)90166-6","article-title":"Characterization of alpha 2-adrenoceptors which increase potassium conductance in rat locus coeruleus neurones","volume":"14","author":"Williams","year":"1985","journal-title":"Neuroscience"},{"issue":"2","key":"10.1016\/j.brainres.2018.03.009_b0465","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1016\/0306-4522(86)90154-5","article-title":"The molecular function of adrenal chromaffin granules: established facts and unresolved topics","volume":"18","author":"Winkler","year":"1986","journal-title":"Neuroscience"},{"issue":"3","key":"10.1016\/j.brainres.2018.03.009_b0470","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1016\/0306-4522(92)90222-N","article-title":"The chromogranins A and B: the first 25 years and future perspectives","volume":"49","author":"Winkler","year":"1992","journal-title":"Neuroscience"},{"issue":"40","key":"10.1016\/j.brainres.2018.03.009_b0475","doi-asserted-by":"crossref","first-page":"23243","DOI":"10.1074\/jbc.270.40.23243","article-title":"Regulated formation of Golgi secretory vesicles containing Alzheimer beta-amyloid precursor protein","volume":"270","author":"Xu","year":"1995","journal-title":"J. Biol. Chem."},{"issue":"3","key":"10.1016\/j.brainres.2018.03.009_b0480","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1177\/002215540104900301","article-title":"A novel procedure for pre-embedding double immunogold-silver labeling at the ultrastructural level","volume":"49","author":"Yi","year":"2001","journal-title":"J. Histochem. Cytochem."},{"issue":"13","key":"10.1016\/j.brainres.2018.03.009_b0485","doi-asserted-by":"crossref","first-page":"2324","DOI":"10.1091\/mbc.e11-02-0159","article-title":"Release mode of large and small dense-core vesicles specified by different synaptotagmin isoforms in PC12 cells","volume":"22","author":"Zhang","year":"2011","journal-title":"Mol. Biol. Cell"}],"container-title":["Brain Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006899318301446?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006899318301446?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,7,2]],"date-time":"2025-07-02T22:36:07Z","timestamp":1751495767000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006899318301446"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,1]]},"references-count":97,"alternative-id":["S0006899318301446"],"URL":"https:\/\/doi.org\/10.1016\/j.brainres.2018.03.009","relation":{},"ISSN":["0006-8993"],"issn-type":[{"type":"print","value":"0006-8993"}],"subject":[],"published":{"date-parts":[[2019,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Amyloid beta peptides, locus coeruleus-norepinephrine system and dense core vesicles","name":"articletitle","label":"Article Title"},{"value":"Brain Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.brainres.2018.03.009","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}