{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T23:56:59Z","timestamp":1789171019241,"version":"build-2803163510"},"reference-count":45,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2018,9,1]],"date-time":"2018-09-01T00:00:00Z","timestamp":1535760000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council grant","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Brain Research"],"published-print":{"date-parts":[[2018,9]]},"DOI":"10.1016\/j.brainres.2018.05.032","type":"journal-article","created":{"date-parts":[[2018,5,22]],"date-time":"2018-05-22T16:25:53Z","timestamp":1527006353000},"page":"10-17","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":12,"special_numbering":"C","title":["Exercise related anxiety-like behaviours are mediated by TNF receptor signaling, but not depression-like behaviours"],"prefix":"10.1016","volume":"1695","author":[{"given":"Julie A.","family":"Morgan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gaurav","family":"Singhal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frances","family":"Corrigan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emily J.","family":"Jaehne","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Magdalene C.","family":"Jawahar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernhard T.","family":"Baune","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.brainres.2018.05.032_b0005","doi-asserted-by":"crossref","first-page":"1116","DOI":"10.1038\/nn738","article-title":"TNF [alpha] promotes proliferation of oligodendrocyte progenitors and remyelination","volume":"4","author":"Arnett","year":"2001","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.brainres.2018.05.032_b0010","doi-asserted-by":"crossref","unstructured":"B. Baune F. Wiede 2008 Cognitive dysfunction in mice deficient for TNF-alpha and its receptors Am. J. Med. Genet. Part B: Neuropsychiat. Genet. 147b 1056 1064","DOI":"10.1002\/ajmg.b.30712"},{"key":"10.1016\/j.brainres.2018.05.032_b0015","doi-asserted-by":"crossref","first-page":"263","DOI":"10.2478\/s13380-012-0027-8","article-title":"Tumour necrosis factor \u2013 ALPHA mediated mechanisms of cognitive dysfunction","volume":"3","author":"Baune","year":"2012","journal-title":"Transl. Neurosci."},{"key":"10.1016\/j.brainres.2018.05.032_b0020","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/j.bbr.2004.04.017","article-title":"Regular voluntary exercise reduces anxiety-related behaviour and impulsiveness in mice","volume":"155","author":"Binder","year":"2004","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.brainres.2018.05.032_b9000","doi-asserted-by":"crossref","first-page":"3102","DOI":"10.1016\/j.psyneuen.2013.09.010","article-title":"TNF-\u03b1 and its receptors modulate complex behaviours and neurotrophins in transgenic mice","volume":"38","author":"Camara","year":"2013","journal-title":"Psychoneuroendocrino."},{"key":"10.1016\/j.brainres.2018.05.032_b0025","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1002\/glia.21134","article-title":"FOXO3a inhibits TNF-\u03b1- and IL-1\u03b2-induced astrocyte proliferation: Implication for reactive astrogliosis","volume":"59","author":"Cui","year":"2011","journal-title":"Glia."},{"key":"10.1016\/j.brainres.2018.05.032_b0030","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1249\/MSS.0b013e31827b23e6","article-title":"The antidepressant-like effect of physical activity on a voluntary running wheel","volume":"45","author":"Cunha","year":"2013","journal-title":"Med. Sci. Sports Exerc."},{"key":"10.1016\/j.brainres.2018.05.032_b0035","doi-asserted-by":"crossref","first-page":"1535","DOI":"10.1023\/A:1021608724117","article-title":"Expression of the p75 TNF receptor is linked to TNF-induced NF\u03baB translocation and oxyradical neutralization in glial cells","volume":"27","author":"Dopp","year":"2002","journal-title":"Neurochem. Res."},{"key":"10.1016\/j.brainres.2018.05.032_b0040","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1016\/j.biopsych.2009.09.033","article-title":"A meta-analysis of cytokines in major depression","volume":"67","author":"Dowlati","year":"2010","journal-title":"Biol. Psychiat."},{"key":"10.1016\/j.brainres.2018.05.032_b0045","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1016\/j.brainres.2007.12.047","article-title":"Voluntary exercise produces antidepressant and anxiolytic behavioral effects in mice","volume":"1199","author":"Duman","year":"2008","journal-title":"Brain Res."},{"key":"10.1016\/j.brainres.2018.05.032_b0050","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.pnpbp.2012.11.009","article-title":"Melancholic and atypical major depression \u2013 connection between cytokines, psychopathology and treatment","volume":"43","author":"Dunjic-Kostic","year":"2013","journal-title":"Prog. Neuro-Psychopharmacol. Biol. Psychiat."},{"key":"10.1016\/j.brainres.2018.05.032_b0055","doi-asserted-by":"crossref","first-page":"1244","DOI":"10.1016\/j.bbi.2012.06.007","article-title":"Increased soluble interleukin-2 receptor levels are related to somatic but not to cognitive-affective features in major depression","volume":"26","author":"Euteneuer","year":"2012","journal-title":"Brain Behav Immun."},{"key":"10.1016\/j.brainres.2018.05.032_b0060","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1016\/0092-8674(95)90192-2","article-title":"The transmembrane form of tumor necrosis factor is the prime activating ligand of the 80 kDa tumor necrosis factor receptor","volume":"83","author":"Grell","year":"1995","journal-title":"Cell"},{"key":"10.1016\/j.brainres.2018.05.032_b0065","series-title":"An Adaptive Role for TNF\u03b1 in Synaptic Plasticity and Neuronal Function. In Neuroinflammation","author":"Heir","year":"2015"},{"key":"10.1016\/j.brainres.2018.05.032_b0070","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1016\/j.eurpsy.2008.03.013","article-title":"Depression, comorbidities and the TNF-alpha system","volume":"23","author":"Himmerich","year":"2008","journal-title":"Eur Psychiat."},{"key":"10.1016\/j.brainres.2018.05.032_b0075","doi-asserted-by":"crossref","first-page":"9703","DOI":"10.1523\/JNEUROSCI.2723-06.2006","article-title":"Tumor necrosis factor receptor 1 is a negative regulator of progenitor proliferation in adult hippocampal neurogenesis","volume":"26","author":"Iosif","year":"2006","journal-title":"J. Neurosci."},{"key":"10.1016\/j.brainres.2018.05.032_b0080","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1016\/j.neuropharm.2011.08.018","article-title":"Depressive-like behavior induced by tumor necrosis factor-alpha in mice","volume":"62","author":"Kaster","year":"2012","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.brainres.2018.05.032_b0085","doi-asserted-by":"crossref","DOI":"10.1111\/acps.12698","article-title":"Peripheral cytokine and chemokine alterations in depression: a meta-analysis of 82 studies","author":"Kohler","year":"2017","journal-title":"Acta Psychiatr. Scand."},{"key":"10.1016\/j.brainres.2018.05.032_b0090","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1016\/j.jpsychires.2013.01.007","article-title":"Antidepressant effects of TNF-\u03b1 blockade in an animal model of depression","volume":"47","author":"Kr\u00fcgel","year":"2013","journal-title":"J. Psychiatr. Res."},{"key":"10.1016\/j.brainres.2018.05.032_b0095","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1016\/j.bbr.2012.12.041","article-title":"Swimming exercise ameliorates depression-like behavior in chronically stressed rats: relevant to proinflammatory cytokines and IDO activation","volume":"242","author":"Liu","year":"2013","journal-title":"Behav Brain Res."},{"key":"10.1016\/j.brainres.2018.05.032_b0100","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1016\/j.jad.2011.08.003","article-title":"Interleukin (IL)-6, tumour necrosis factor alpha (TNF-\u03b1) and soluble interleukin-2 receptors (sIL-2R) are elevated in patients with major depressive disorder: a meta-analysis and meta-regression","volume":"139","author":"Liu","year":"2012","journal-title":"J. Affect. Disord."},{"key":"10.1016\/j.brainres.2018.05.032_b0105","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1006\/cyto.1997.0290","article-title":"The effects of psychological stress on humans: increased production of pro-inflammatory cytokines and a Th1-like response in stress-induced anxiety","volume":"10","author":"Maes","year":"1998","journal-title":"Cytokine"},{"key":"10.1016\/j.brainres.2018.05.032_b0110","doi-asserted-by":"crossref","first-page":"943","DOI":"10.1002\/dneu.22009","article-title":"Running throughout middle-age improves memory function, hippocampal neurogenesis, and BDNF levels in female C57BL\/6J mice","volume":"72","author":"Marlatt","year":"2012","journal-title":"Develop. Neurobiol."},{"key":"10.1016\/j.brainres.2018.05.032_b0115","doi-asserted-by":"crossref","DOI":"10.3390\/ijms17122022","article-title":"Peripheral inflammatory parameters in late-life depression: a systematic review","volume":"17","author":"Martinez-Cengotitabengoa","year":"2016","journal-title":"Int J Mol Sci."},{"key":"10.1016\/j.brainres.2018.05.032_b0120","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1186\/1742-2094-5-45","article-title":"TNF signaling inhibition in the CNS: implications for normal brain function and neurodegenerative disease","volume":"5","author":"McCoy","year":"2008","journal-title":"J. Neuroinflamm."},{"key":"10.1016\/j.brainres.2018.05.032_b0125","article-title":"The effects of aerobic exercise on depression-like, anxiety-like, and cognition-like behaviours over the healthy adult lifespan of C57BL\/6 mice","author":"Morgan","year":"2017","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.brainres.2018.05.032_b0130","doi-asserted-by":"crossref","first-page":"114","DOI":"10.4103\/0253-7176.178772","article-title":"Is Depression an inflammatory disease? findings from a cross-sectional study at a tertiary care center","volume":"38","author":"Muthuramalingam","year":"2016","journal-title":"Indian J. Psychol. Med."},{"key":"10.1016\/j.brainres.2018.05.032_b0135","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1007\/s00213-008-1331-4","article-title":"The type 1 TNF receptor and its associated adapter protein, FAN, are required for TNF\u03b1-induced sickness behavior","volume":"201","author":"Palin","year":"2009","journal-title":"Psychopharmacology"},{"key":"10.1016\/j.brainres.2018.05.032_b0140","doi-asserted-by":"crossref","first-page":"1276","DOI":"10.1016\/j.bbi.2010.05.005","article-title":"Lack of aggression and anxiolytic-like behavior in TNF receptor (TNF-R1 and TNF-R2) deficient mice","volume":"24","author":"Patel","year":"2010","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.brainres.2018.05.032_b0145","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.physbeh.2014.03.016","article-title":"Moderate treadmill exercise rescues anxiety and depression-like behavior as well as memory impairment in a rat model of posttraumatic stress disorder","volume":"130","author":"Patki","year":"2014","journal-title":"Physiol. Behav."},{"key":"10.1016\/j.brainres.2018.05.032_b0150","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1055\/s-0031-1279780","article-title":"Freewheel training alters mouse hippocampal cytokines","volume":"32","author":"Pervaiz","year":"2011","journal-title":"Int. J. Sport. Med."},{"key":"10.1016\/j.brainres.2018.05.032_b0155","doi-asserted-by":"crossref","first-page":"1154","DOI":"10.1152\/japplphysiol.00164.2004","article-title":"The anti-inflammatory effect of exercise","volume":"98","author":"Petersen","year":"2005","journal-title":"J. Appl. Physiol."},{"key":"10.1016\/j.brainres.2018.05.032_b0160","first-page":"43","article-title":"The role of IL-6 in mediating the anti-inflammatory effects of exercise","volume":"57","author":"Petersen","year":"2006","journal-title":"J. Physiol. Pharmacol."},{"key":"10.1016\/j.brainres.2018.05.032_b0165","doi-asserted-by":"crossref","first-page":"3869","DOI":"10.4049\/jimmunol.158.8.3869","article-title":"Constitutive shedding of both p55 and p75 murine TNF receptors in vivo","volume":"158","author":"Pinckard","year":"1997","journal-title":"J. Immunol."},{"key":"10.1016\/j.brainres.2018.05.032_b0170","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1016\/0014-2999(78)90118-8","article-title":"Behavioural despair in rats: a new model sensitive to antidepressant treatments","volume":"47","author":"Porsolt","year":"1978","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.brainres.2018.05.032_b0175","doi-asserted-by":"crossref","first-page":"1119","DOI":"10.1038\/mp.2012.125","article-title":"Pro-inflammatory cytokines as predictors of antidepressant effects of exercise in major depressive disorder","volume":"18","author":"Rethorst","year":"2013","journal-title":"Mol Psychiat."},{"key":"10.1016\/j.brainres.2018.05.032_b0180","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1016\/j.psychres.2016.04.049","article-title":"Abnormal gene expression of proinflammatory cytokines and their membrane-bound receptors in the lymphocytes of depressed patients","volume":"240","author":"Rizavi","year":"2016","journal-title":"Psychiatry Res."},{"key":"10.1016\/j.brainres.2018.05.032_b0185","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1016\/j.bbr.2009.12.039","article-title":"Moderate treadmill exercise prevents oxidative stress-induced anxiety-like behavior in rats","volume":"208","author":"Salim","year":"2010","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.brainres.2018.05.032_b0190","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1016\/j.cytogfr.2014.07.016","article-title":"TNF and TNF-receptors: From mediators of cell death and inflammation to therapeutic giants - past, present and future","volume":"25","author":"Sedger","year":"2014","journal-title":"Cytokine Growth Factor Rev."},{"key":"10.1016\/j.brainres.2018.05.032_b0195","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1016\/j.biopsych.2005.10.013","article-title":"TNFa Signaling in depression and anxiety: behavioral consequences of individual receptor targeting","volume":"59","author":"Simen","year":"2006","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.brainres.2018.05.032_b0200","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1016\/0306-9877(91)90272-Z","article-title":"The macrophage theory of depression","volume":"35","author":"Smith","year":"1991","journal-title":"Med. Hypoth."},{"key":"10.1016\/j.brainres.2018.05.032_b0205","doi-asserted-by":"crossref","first-page":"1532","DOI":"10.1016\/j.euroneuro.2015.06.007","article-title":"Inflammation and clinical response to treatment in depression: a meta-analysis","volume":"25","author":"Strawbridge","year":"2015","journal-title":"Eur Neuropsychopharmacol."},{"key":"10.1016\/j.brainres.2018.05.032_b0210","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1016\/j.jneuroim.2010.07.018","article-title":"Enhanced Th17 phenotype in individuals with generalized anxiety disorder","volume":"229","author":"Vieira","year":"2010","journal-title":"J. Neuroimmunol."},{"key":"10.1016\/j.brainres.2018.05.032_b0215","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1038\/sj.cdd.4401189","article-title":"Tumor necrosis factor signaling","volume":"10","author":"Wajant","year":"2003","journal-title":"Cell Death Differ."},{"key":"10.1016\/j.brainres.2018.05.032_b0220","doi-asserted-by":"crossref","first-page":"3025","DOI":"10.1523\/JNEUROSCI.22-08-03025.2002","article-title":"Target depletion of distinct tumor necrosis factor receptor subtypes reveals hippocampal neuron death and survival through different signal transduction pathways","volume":"22","author":"Yang","year":"2002","journal-title":"J. Neurosci."}],"container-title":["Brain Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006899318302890?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006899318302890?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2023,9,2]],"date-time":"2023-09-02T19:21:25Z","timestamp":1693682485000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006899318302890"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,9]]},"references-count":45,"alternative-id":["S0006899318302890"],"URL":"https:\/\/doi.org\/10.1016\/j.brainres.2018.05.032","relation":{},"ISSN":["0006-8993"],"issn-type":[{"value":"0006-8993","type":"print"}],"subject":[],"published":{"date-parts":[[2018,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Exercise related anxiety-like behaviours are mediated by TNF receptor signaling, but not depression-like behaviours","name":"articletitle","label":"Article Title"},{"value":"Brain Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.brainres.2018.05.032","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}