{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,5]],"date-time":"2025-12-05T12:16:49Z","timestamp":1764937009775,"version":"3.37.3"},"reference-count":47,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2018,11,1]],"date-time":"2018-11-01T00:00:00Z","timestamp":1541030400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100000209","name":"National Academy of Sciences","doi-asserted-by":"publisher","award":["F76\/13-2018"],"award-info":[{"award-number":["F76\/13-2018"]}],"id":[{"id":"10.13039\/100000209","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Brain Research"],"published-print":{"date-parts":[[2018,11]]},"DOI":"10.1016\/j.brainres.2018.06.032","type":"journal-article","created":{"date-parts":[[2018,7,3]],"date-time":"2018-07-03T08:50:57Z","timestamp":1530607857000},"page":"69-78","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":11,"special_numbering":"C","title":["Levetiracetam-mediated improvement of decreased NMDA-induced glutamate release from nerve terminals during hypothermia"],"prefix":"10.1016","volume":"1699","author":[{"given":"A.","family":"Pastukhov","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T.","family":"Borisova","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.brainres.2018.06.032_b0005","doi-asserted-by":"crossref","first-page":"1276","DOI":"10.1111\/j.1528-1157.2000.tb04605.x","article-title":"Efficacy and tolerability of levetiracetam 3000 mg\/d in patients with refractory partial seizures: a multicenter, double-blind, responder-selected study evaluating monotherapy. European Levetiracetam Study Group","volume":"41","author":"Ben-Menachem","year":"2000","journal-title":"Epilepsia"},{"key":"10.1016\/j.brainres.2018.06.032_b0010","doi-asserted-by":"crossref","first-page":"1751","DOI":"10.1212\/01.wnl.0000268699.34614.d3","article-title":"Levetiracetam, N01057 Study Group Placebo-controlled study of levetiracetam in idiopathic generalized epilepsy","volume":"69","author":"Berkovic","year":"2007","journal-title":"Neurology"},{"key":"10.1016\/j.brainres.2018.06.032_b0015","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1007\/PL00005097","article-title":"Levetiracetam (ucb LO59) affects in vitro models of epilepsy in CA3 pyramidal neurons without altering normal synaptic transmission","volume":"356","author":"Birnstiel","year":"1997","journal-title":"Naunyn. Schmiedebergs. Arch. Pharmacol."},{"key":"10.1016\/j.brainres.2018.06.032_b0020","doi-asserted-by":"crossref","DOI":"10.3389\/fphys.2018.00728","article-title":"Nervous system injury in response to contact with environmental, engineered and planetary micro- and nano-sized particles","volume":"9","author":"Borisova","year":"2018","journal-title":"Front. Physiol."},{"key":"10.1016\/j.brainres.2018.06.032_b0025","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1515\/revneuro-2015-0023","article-title":"Permanent dynamic transporter-mediated turnover of glutamate across the plasma membrane of presynaptic nerve terminals: arguments in favor and against","volume":"27","author":"Borisova","year":"2016","journal-title":"Rev. Neurosci."},{"key":"10.1016\/j.brainres.2018.06.032_b0030","first-page":"89","article-title":"The neurotoxic effects of heavy metals: Alterations in acidification of synaptic vesicles and glutamate transport in brain nerve terminals","volume":"14","author":"Borisova","year":"2014","journal-title":"Horizons Neurosci. Res."},{"year":"2013","series-title":"Cholesterol and Presynaptic Glutamate Transport in the Brain, SpringerBriefs in Neuroscience","author":"Borisova","key":"10.1016\/j.brainres.2018.06.032_b0035"},{"key":"10.1016\/j.brainres.2018.06.032_b0040","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1515\/revneuro-2015-0044","article-title":"Putative duality of presynaptic events","volume":"27","author":"Borisova","year":"2016","journal-title":"Rev. Neurosci."},{"key":"10.1016\/j.brainres.2018.06.032_b0045","doi-asserted-by":"crossref","first-page":"1229","DOI":"10.1007\/s10571-015-0321-4","article-title":"Dynamic gradient of glutamate across the membrane: glutamate\/aspartate-induced changes in the ambient level of l-[(14)C]glutamate and d-[(3)H]aspartate in rat brain nerve terminals","volume":"36","author":"Borisova","year":"2016","journal-title":"Cell. Mol. Neurobiol."},{"key":"10.1016\/j.brainres.2018.06.032_b0055","doi-asserted-by":"crossref","first-page":"1340","DOI":"10.1016\/j.asr.2005.10.007","article-title":"Centrifuge-induced hypergravity: [3H]GABA and l-[14C]glutamate uptake, exocytosis and efflux mediated by high-affinity, sodium-dependent transporters","volume":"36","author":"Borisova","year":"2005","journal-title":"Adv. Sp. Res."},{"key":"10.1016\/j.brainres.2018.06.032_b0060","doi-asserted-by":"crossref","first-page":"654","DOI":"10.1111\/j.1528-1167.2006.00973.x","article-title":"Modulation of AMPA receptors in cultured cortical neurons induced by the antiepileptic drug levetiracetam","volume":"48","author":"Carunchio","year":"2007","journal-title":"Epilepsia"},{"key":"10.1016\/j.brainres.2018.06.032_b0065","first-page":"1094","article-title":"Hypoxic-ischemic brain injury and prognosis after cardiac arrest","volume":"17","author":"Chiota","year":"2011","journal-title":"Continuum (Minneap. Minn)"},{"key":"10.1016\/j.brainres.2018.06.032_b0070","first-page":"133","article-title":"Therapeutic hypothermia in neonatal asphyxia. Facts, views","volume":"4","author":"Cornette","year":"2012","journal-title":"Vis ObGyn"},{"key":"10.1016\/j.brainres.2018.06.032_b0075","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1016\/0076-6879(74)31050-6","article-title":"Isolation of synaptosomal and synaptic plasma membrane fractions","volume":"31","author":"Cotman","year":"1974","journal-title":"Methods Enzymol."},{"key":"10.1016\/j.brainres.2018.06.032_b0080","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1007\/s00415-005-0726-y","article-title":"Effects of levetiracetam on the production of nitric oxide\u2013an in vivo study","volume":"252","author":"Dagonnier","year":"2005","journal-title":"J. Neurol."},{"key":"10.1016\/j.brainres.2018.06.032_b0085","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1111\/j.1527-3458.2007.00004.x","article-title":"Levetiracetam: the profile of a novel anticonvulsant drug-part I: preclinical data","volume":"13","author":"De Smedt","year":"2007","journal-title":"CNS Drug Rev."},{"key":"10.1016\/j.brainres.2018.06.032_b0090","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1016\/j.eplepsyres.2012.04.007","article-title":"Rare protein sequence variation in SV2A gene does not affect response to levetiracetam","volume":"101","author":"Dibbens","year":"2012","journal-title":"Epilepsy Res."},{"key":"10.1016\/j.brainres.2018.06.032_b0095","first-page":"184","article-title":"Degree of hypothermia in aortic arch surgery \u2013 optimal temperature for cerebral and spinal protection: deep hypothermia remains the gold standard in the absence of randomized data","volume":"2","author":"Englum","year":"2013","journal-title":"Ann. Cardiothorac. Surg."},{"key":"10.1016\/j.brainres.2018.06.032_b0100","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1046\/j.1528-1157.2002.18101.x","article-title":"Effects of the novel antiepileptic drug levetiracetam on spontaneous recurrent seizures in the rat pilocarpine model of temporal lobe epilepsy","volume":"43","author":"Glien","year":"2002","journal-title":"Epilepsia"},{"key":"10.1016\/j.brainres.2018.06.032_b0105","doi-asserted-by":"crossref","first-page":"1577","DOI":"10.1111\/j.1476-5381.2010.00872.x","article-title":"Animal research: reporting in vivo experiments: The ARRIVE guidelines","volume":"160","author":"Kilkenny","year":"2010","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.brainres.2018.06.032_b0110","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1111\/j.1528-1167.2001.00003.x","article-title":"Levetiracetam: The Preclinical Profile of a New Class of Antiepileptic Drugs?","volume":"42","author":"Klitgaard","year":"2008","journal-title":"Epilepsia"},{"key":"10.1016\/j.brainres.2018.06.032_b0115","doi-asserted-by":"crossref","DOI":"10.1155\/2012\/295906","article-title":"Application of mild therapeutic hypothermia on stroke: a systematic review and meta-analysis","author":"Lakhan","year":"2012","journal-title":"Stroke Res. Treat."},{"key":"10.1016\/j.brainres.2018.06.032_b0120","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1016\/0003-2697(86)90432-X","article-title":"Artificial reductant enhancement of the Lowry method for protein determination","volume":"155","author":"Larson","year":"1986","journal-title":"Anal. Biochem."},{"key":"10.1016\/j.brainres.2018.06.032_b0125","doi-asserted-by":"crossref","first-page":"1753","DOI":"10.1111\/j.1476-5381.2009.00463.x","article-title":"Levetiracetam inhibits glutamate transmission through presynaptic P\/Q-type calcium channels on the granule cells of the dentate gyrus","volume":"158","author":"Lee","year":"2009","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.brainres.2018.06.032_b0130","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1179\/174313209X444099","article-title":"Clinical application of therapeutic hypothermia in stroke","volume":"31","author":"Liu","year":"2009","journal-title":"Neurol. Res."},{"key":"10.1016\/j.brainres.2018.06.032_b0135","doi-asserted-by":"crossref","first-page":"816","DOI":"10.2741\/2104","article-title":"Therapeutic hypothermia: neuroprotective mechanisms","volume":"12","author":"Liu","year":"2007","journal-title":"Front. Biosci."},{"key":"10.1016\/j.brainres.2018.06.032_b0140","doi-asserted-by":"crossref","first-page":"1573","DOI":"10.1111\/j.1476-5381.2010.00873.x","article-title":"Guidelines for reporting experiments involving animals: the ARRIVE guidelines","volume":"160","author":"McGrath","year":"2010","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.brainres.2018.06.032_b0145","article-title":"Brain temperature: Physiology and pathophysiology after brain injury","volume":"2012","author":"Mrozek","year":"2012","journal-title":"Anesthesiol. Res. Pract."},{"key":"10.1016\/j.brainres.2018.06.032_b0150","doi-asserted-by":"crossref","DOI":"10.1089\/ther.2017.0047","article-title":"Combined Application of Glutamate Transporter Inhibitors and Hypothermia Discriminates Principal Constituent Processes Involved in Glutamate Homo- and Heteroexchange in Brain Nerve Terminals","author":"Pastukhov","year":"2018","journal-title":"Ther. Hypothermia Temp. Manage."},{"key":"10.1016\/j.brainres.2018.06.032_b0155","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1186\/s13167-016-0075-1","article-title":"Personalized approach in brain protection by hypothermia: individual changes in non-pathological and ischemia-related glutamate transport in brain nerve terminals","volume":"7","author":"Pastukhov","year":"2016","journal-title":"EPMA J."},{"key":"10.1016\/j.brainres.2018.06.032_b0160","doi-asserted-by":"crossref","first-page":"608","DOI":"10.1002\/syn.21547","article-title":"Role of perisynaptic parameters in neurotransmitter homeostasis\u2013computational study of a general synapse","volume":"66","author":"Pendyam","year":"2012","journal-title":"Synapse"},{"key":"10.1016\/j.brainres.2018.06.032_b0165","doi-asserted-by":"crossref","first-page":"1281","DOI":"10.1016\/S0306-4522(98)00573-9","article-title":"A high-affinity presynaptic kainate-type glutamate receptor facilitates glutamate exocytosis from cerebral cortex nerve terminals (synaptosomes)","volume":"90","author":"Perkinton","year":"1999","journal-title":"Neuroscience"},{"key":"10.1016\/j.brainres.2018.06.032_b0170","doi-asserted-by":"crossref","first-page":"250","DOI":"10.3325\/cmj.2014.55.250","article-title":"Perinatal hypoxia: different effects of the inhibitors of GABA transporters GAT1 and GAT3 on the initial velocity of [3H]GABA uptake by cortical, hippocampal, and thalamic nerve terminals","volume":"55","author":"Pozdnyakova","year":"2014","journal-title":"Croat. Med. J."},{"key":"10.1016\/j.brainres.2018.06.032_b0175","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1038\/sj.bjp.0704766","article-title":"The anti-epileptic drug levetiracetam reverses the inhibition by negative allosteric modulators of neuronal GABA- and glycine-gated currents","volume":"136","author":"Rigo","year":"2002","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.brainres.2018.06.032_b0180","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1016\/S0005-2736(01)00301-7","article-title":"Nonlinear temperature modulation of sodium channel kinetics in GH(3) cells","volume":"1511","author":"Rosen","year":"2001","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.brainres.2018.06.032_b0185","doi-asserted-by":"crossref","first-page":"C863","DOI":"10.1152\/ajpcell.1996.271.3.C863","article-title":"Temperature modulation of calcium channel function in GH3 cells","volume":"271","author":"Rosen","year":"1996","journal-title":"Am. J. Physiol."},{"key":"10.1016\/j.brainres.2018.06.032_b0190","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/S0169-328X(01)00069-9","article-title":"Presynaptic N-methyl-d-aspartate receptor activation inhibits neurotransmitter release through nitric oxide formation in rat hippocampal nerve terminals","volume":"89","author":"Sequeira","year":"2001","journal-title":"Brain Res. Mol. Brain Res."},{"key":"10.1016\/j.brainres.2018.06.032_b0195","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1227\/01.NEU.0000336312.32773.A0","article-title":"Therapeutic hypothermia in patients with aneurysmal subarachnoid hemorrhage, refractory intracranial hypertension, or cerebral vasospasm","volume":"64","author":"Seule","year":"2009","journal-title":"Neurosurgery"},{"key":"10.1016\/j.brainres.2018.06.032_b0200","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1016\/j.brainres.2016.05.040","article-title":"Dose-dependent effects of levetiracetam after hypoxia and hypothermia in the neonatal mouse brain","volume":"1646","author":"Strasser","year":"2016","journal-title":"Brain Res."},{"key":"10.1016\/j.brainres.2018.06.032_b0205","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1146\/annurev.neuro.26.041002.131412","article-title":"The synaptic vesicle cycle","volume":"27","author":"Sudhof","year":"2004","journal-title":"Annu. Rev. Neurosci."},{"key":"10.1016\/j.brainres.2018.06.032_b0210","first-page":"558","article-title":"Levetiracetam enhances \u03b17 ach receptor responses by indirectly interacting protein kinase a and protein kinase c","volume":"6","author":"Tsudaka","year":"2015","journal-title":"Int. J. Biol. Pharm. Res."},{"key":"10.1016\/j.brainres.2018.06.032_b0215","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.brainres.2007.03.021","article-title":"Effect of levetiracetam on molecular regulation of hippocampal glutamate and GABA transporters in rats with chronic seizures induced by amygdalar FeCl3 injection","volume":"1151","author":"Ueda","year":"2007","journal-title":"Brain Res."},{"key":"10.1016\/j.brainres.2018.06.032_b0220","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1007\/s11910-012-0304-5","article-title":"Therapeutic hypothermia for traumatic brain injury","volume":"12","author":"Urbano","year":"2012","journal-title":"Curr. Neurol. Neurosci. Rep."},{"key":"10.1016\/j.brainres.2018.06.032_b0225","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1152\/jn.01166.2003","article-title":"Probability of transmitter release at neocortical synapses at different temperatures","volume":"92","author":"Volgushev","year":"2004","journal-title":"J. Neurophysiol."},{"key":"10.1016\/j.brainres.2018.06.032_b0230","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/S0306-4522(00)00109-3","article-title":"Synaptic transmission in the neocortex during reversible cooling","volume":"98","author":"Volgushev","year":"2000","journal-title":"Neuroscience"},{"key":"10.1016\/j.brainres.2018.06.032_b0235","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1124\/jpet.113.208751","article-title":"Inhibition of excitatory synaptic transmission in hippocampal neurons by Levetiracetam Involves Zn2+-dependent GABA Type A receptor-mediated presynaptic modulation","volume":"348","author":"Wakita","year":"2014","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.brainres.2018.06.032_b0240","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1111\/j.1747-4949.2012.00839.x","article-title":"Pathophysiologic cascades in ischemic stroke","volume":"7","author":"Xing","year":"2012","journal-title":"Int. J. Stroke"}],"container-title":["Brain Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006899318303652?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006899318303652?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,10,16]],"date-time":"2018-10-16T16:49:12Z","timestamp":1539708552000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006899318303652"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,11]]},"references-count":47,"alternative-id":["S0006899318303652"],"URL":"https:\/\/doi.org\/10.1016\/j.brainres.2018.06.032","relation":{},"ISSN":["0006-8993"],"issn-type":[{"type":"print","value":"0006-8993"}],"subject":[],"published":{"date-parts":[[2018,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Levetiracetam-mediated improvement of decreased NMDA-induced glutamate release from nerve terminals during hypothermia","name":"articletitle","label":"Article Title"},{"value":"Brain Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.brainres.2018.06.032","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}