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Neurosci."},{"key":"10.1016\/j.brainres.2018.07.027_b0350","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.neuint.2009.08.012","article-title":"The orexin-1 receptor antagonist SB-334867 reduces amphetamine-evoked dopamine outflow in the shell of the nucleus accumbens and decreases the expression of amphetamine sensitization","volume":"56","author":"Quarta","year":"2010","journal-title":"Neurochem. Int."},{"key":"10.1016\/j.brainres.2018.07.027_b0355","doi-asserted-by":"crossref","first-page":"10423","DOI":"10.1038\/ncomms10423","article-title":"Membrane potential shapes regulation of dopamine transporter trafficking at the plasma membrane","volume":"7","author":"Richardson","year":"2016","journal-title":"Nat. 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Neurosci."},{"key":"10.1016\/j.brainres.2018.07.027_b0415","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1146\/annurev.psych.55.090902.141545","article-title":"HYPOCRETIN (OREXIN): role in normal behavior and neuropathology *","volume":"55","author":"Siegel","year":"2004","journal-title":"Annu. Rev. Psychol."},{"key":"10.1016\/j.brainres.2018.07.027_b0420","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1111\/j.1460-9568.2009.06844.x","article-title":"Orexin\/hypocretin signaling at the orexin 1 receptor regulates cue-elicited cocaine-seeking","volume":"30","author":"Smith","year":"2009","journal-title":"Eur. J. 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Neurol."},{"key":"10.1016\/j.brainres.2018.07.027_b0435","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/S0014-5793(99)01030-3","article-title":"Distribution and quantification of immunoreactive orexin A in rat tissues","volume":"457","author":"Taheri","year":"1999","journal-title":"FEBS Lett."},{"key":"10.1016\/j.brainres.2018.07.027_b0440","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/S0014-5793(98)01266-6","article-title":"Distribution of orexin receptor mRNA in the rat brain","volume":"438","author":"Trivedi","year":"1998","journal-title":"FEBS Lett."},{"key":"10.1016\/j.brainres.2018.07.027_b0445","doi-asserted-by":"crossref","first-page":"12199","DOI":"10.1038\/ncomms12199","article-title":"Orexins contribute to restraint stress-induced cocaine relapse by endocannabinoid-mediated disinhibition of dopaminergic neurons","volume":"7","author":"Tung","year":"2016","journal-title":"Nat. Commun."},{"key":"10.1016\/j.brainres.2018.07.027_b0450","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1016\/j.biopsych.2009.01.018","article-title":"Reinstatement of cocaine seeking by hypocretin (orexin) in the ventral tegmental area: independence from the local corticotropin-releasing factor network","volume":"65","author":"Wang","year":"2009","journal-title":"Biol. Psychiatry."},{"key":"10.1016\/j.brainres.2018.07.027_b0455","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/S0376-8716(98)00072-6","article-title":"Neuroadaptations involved in amphetamine and cocaine addiction","volume":"51","author":"White","year":"1998","journal-title":"Drug Alcohol Depend."},{"key":"10.1016\/j.brainres.2018.07.027_b0460","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1146\/annurev.neuro.24.1.429","article-title":"To eat or to sleep? orexin in the regulation of feeding and wakefulness","volume":"24","author":"Willie","year":"2001","journal-title":"Annu. Rev. Neurosci."},{"key":"10.1016\/j.brainres.2018.07.027_b0465","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1016\/S0896-6273(03)00330-1","article-title":"Distinct narcolepsy syndromes in Orexin receptor-2 and Orexin null mice: molecular genetic dissection of Non-REM and REM sleep regulatory processes","volume":"38","author":"Willie","year":"2003","journal-title":"Neuron"},{"key":"10.1016\/j.brainres.2018.07.027_b0470","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/j.neuropharm.2009.07.008","article-title":"Orexin receptor antagonism prevents transcriptional and behavioral plasticity resulting from stimulant exposure","volume":"58","author":"Winrow","year":"2010","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.brainres.2018.07.027_b0475","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/S0165-0270(01)00459-9","article-title":"Determination of release and uptake parameters from electrically evoked dopamine dynamics measured by real-time voltammetry","volume":"112","author":"Wu","year":"2001","journal-title":"J. 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