{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T17:24:12Z","timestamp":1790270652711,"version":"4.1.0"},"reference-count":77,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2018,11,1]],"date-time":"2018-11-01T00:00:00Z","timestamp":1541030400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Brain Research"],"published-print":{"date-parts":[[2018,11]]},"DOI":"10.1016\/j.brainres.2018.08.014","type":"journal-article","created":{"date-parts":[[2018,8,10]],"date-time":"2018-08-10T16:16:17Z","timestamp":1533917777000},"page":"121-134","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":22,"special_numbering":"C","title":["Distinctive temporal profiles of detergent-soluble and -insoluble tau and A\u03b2 species in human Alzheimer\u2019s disease"],"prefix":"10.1016","volume":"1699","author":[{"given":"David J.","family":"Koss","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marina","family":"Dubini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heather","family":"Buchanan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claire","family":"Hull","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7852-0749","authenticated-orcid":false,"given":"Bettina","family":"Platt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"Pt 21","key":"10.1016\/j.brainres.2018.08.014_b0005","doi-asserted-by":"crossref","first-page":"3737","DOI":"10.1242\/jcs.113.21.3737","article-title":"C-terminal inhibition of tau assembly in vitro and in Alzheimer's disease","volume":"113","author":"Abraha","year":"2000","journal-title":"J. Cell Sci."},{"issue":"4","key":"10.1016\/j.brainres.2018.08.014_b0010","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1111\/j.1750-3639.2008.00147.x","article-title":"Staging of neurofibrillary pathology in Alzheimer's disease: a study of the BrainNet Europe Consortium","volume":"18","author":"Alafuzoff","year":"2008","journal-title":"Brain Pathology (Zurich, Switzerland)"},{"issue":"3 Pt 1","key":"10.1016\/j.brainres.2018.08.014_b0015","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1212\/WNL.42.3.631","article-title":"Neurofibrillary tangles but not senile plaques parallel duration and severity of Alzheimer's disease","volume":"42","author":"Arriagada","year":"1992","journal-title":"Neurology"},{"issue":"1","key":"10.1016\/j.brainres.2018.08.014_b0025","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1038\/nchembio.719","article-title":"Small-molecule conversion of toxic oligomers to nontoxic beta-sheet-rich amyloid fibrils","volume":"8","author":"Bieschke","year":"2011","journal-title":"Nat. Chem. Biol."},{"issue":"4","key":"10.1016\/j.brainres.2018.08.014_b0030","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1007\/s00401-014-1308-9","article-title":"A comparison of Abeta amyloid pathology staging systems and correlation with clinical diagnosis","volume":"128","author":"Boluda","year":"2014","journal-title":"Acta Neuropathol."},{"issue":"3","key":"10.1016\/j.brainres.2018.08.014_b0035","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/0197-4580(95)00021-6","article-title":"Staging of Alzheimer's disease-related neurofibrillary changes","volume":"16","author":"Braak","year":"1995","journal-title":"Neurobiol. Aging"},{"issue":"11","key":"10.1016\/j.brainres.2018.08.014_b0040","doi-asserted-by":"crossref","first-page":"960","DOI":"10.1097\/NEN.0b013e318232a379","article-title":"Stages of the pathologic process in Alzheimer disease: age categories from 1 to 100 years","volume":"70","author":"Braak","year":"2011","journal-title":"J. Neuropathol. Exp. Neurol."},{"issue":"1","key":"10.1016\/j.brainres.2018.08.014_b0050","doi-asserted-by":"crossref","first-page":"546","DOI":"10.1016\/S0021-9258(18)48529-8","article-title":"Assembly and aggregation properties of synthetic Alzheimer's A4\/beta amyloid peptide analogs","volume":"267","author":"Burdick","year":"1992","journal-title":"J. Biol. Chem."},{"issue":"Suppl 1","key":"10.1016\/j.brainres.2018.08.014_b0055","doi-asserted-by":"crossref","first-page":"S97","DOI":"10.3233\/JAD-132477","article-title":"Specific targeting of tau oligomers in Htau mice prevents cognitive impairment and tau toxicity following injection with brain-derived tau oligomeric seeds","volume":"40","author":"Castillo-Carranza","year":"2014","journal-title":"J. Alzheimer's Dis.: JAD"},{"issue":"3","key":"10.1016\/j.brainres.2018.08.014_b0060","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1016\/j.ajpath.2017.11.011","article-title":"Discrete pools of oligomeric amyloid-beta track with spatial learning deficits in a mouse model of alzheimer amyloidosis","volume":"188","author":"Chiang","year":"2018","journal-title":"Am. J. Pathol."},{"issue":"1","key":"10.1016\/j.brainres.2018.08.014_b0065","first-page":"65","article-title":"Stability of early-stage amyloid-beta(1\u201342) aggregation species","volume":"1834","author":"Coalier","year":"2013","journal-title":"BBA"},{"key":"10.1016\/j.brainres.2018.08.014_b0070","doi-asserted-by":"crossref","first-page":"17191","DOI":"10.1038\/srep17191","article-title":"Rescue from tau-induced neuronal dysfunction produces insoluble tau oligomers","volume":"5","author":"Cowan","year":"2015","journal-title":"Sci. Rep."},{"key":"10.1016\/j.brainres.2018.08.014_b0075","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/j.neurobiolaging.2016.07.015","article-title":"Analysis of isoform-specific tau aggregates suggests a common toxic mechanism involving similar pathological conformations and axonal transport inhibition","volume":"47","author":"Cox","year":"2016","journal-title":"Neurobiol. Aging"},{"issue":"6","key":"10.1016\/j.brainres.2018.08.014_b0080","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1007\/s00401-014-1349-0","article-title":"Primary age-related tauopathy (PART): a common pathology associated with human aging","volume":"128","author":"Crary","year":"2014","journal-title":"Acta Neuropathol."},{"issue":"1","key":"10.1016\/j.brainres.2018.08.014_b0085","doi-asserted-by":"crossref","first-page":"123","DOI":"10.2353\/ajpath.2008.070627","article-title":"Analysis of tau phosphorylation and truncation in a mouse model of human tauopathy","volume":"172","author":"Delobel","year":"2008","journal-title":"Am. J. Pathol."},{"issue":"28","key":"10.1016\/j.brainres.2018.08.014_b0090","doi-asserted-by":"crossref","first-page":"19107","DOI":"10.1074\/jbc.M511697200","article-title":"Site-specific phosphorylation and caspase cleavage differentially impact tau-microtubule interactions and tau aggregation","volume":"281","author":"Ding","year":"2006","journal-title":"J. Biol. Chem."},{"issue":"1","key":"10.1016\/j.brainres.2018.08.014_b0095","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1097\/nen.0b013e31802c3e7d","article-title":"Brain protein preservation largely depends on the postmortem storage temperature: implications for study of proteins in human neurologic diseases and management of brain banks: a BrainNet Europe Study","volume":"66","author":"Ferrer","year":"2007","journal-title":"J. Neuropathol. Exp. Neurol."},{"issue":"28","key":"10.1016\/j.brainres.2018.08.014_b0110","doi-asserted-by":"crossref","first-page":"10223","DOI":"10.1021\/bi980537d","article-title":"Rapid assembly of Alzheimer-like paired helical filaments from microtubule-associated protein tau monitored by fluorescence in solution","volume":"37","author":"Friedhoff","year":"1998","journal-title":"Biochemistry"},{"key":"10.1016\/j.brainres.2018.08.014_b0115","doi-asserted-by":"crossref","first-page":"93","DOI":"10.3389\/fneur.2013.00093","article-title":"Formation and propagation of tau oligomeric seeds","volume":"4","author":"Gerson","year":"2013","journal-title":"Front. Neurol."},{"issue":"9","key":"10.1016\/j.brainres.2018.08.014_b0120","doi-asserted-by":"crossref","first-page":"1495","DOI":"10.1212\/01.WNL.0000063311.58879.01","article-title":"Tangle and neuron numbers, but not amyloid load, predict cognitive status in Alzheimer's disease","volume":"60","author":"Giannakopoulos","year":"2003","journal-title":"Neurology"},{"issue":"6","key":"10.1016\/j.brainres.2018.08.014_b0125","doi-asserted-by":"crossref","first-page":"1509","DOI":"10.1046\/j.1471-4159.2003.02287.x","article-title":"Pseudophosphorylation of tau protein alters its ability for self-aggregation","volume":"88","author":"Haase","year":"2004","journal-title":"J. Neurochem."},{"issue":"11","key":"10.1016\/j.brainres.2018.08.014_b0130","doi-asserted-by":"crossref","first-page":"2639","DOI":"10.1021\/bi00463a003","article-title":"Molecular determinants of amyloid deposition in Alzheimer's disease: conformational studies of synthetic beta-protein fragments","volume":"29","author":"Halverson","year":"1990","journal-title":"Biochemistry"},{"issue":"1","key":"10.1016\/j.brainres.2018.08.014_b0135","first-page":"44","article-title":"A Quantitative analysis of brain soluble tau and the tau secretion factor","volume":"76","author":"Han","year":"2017","journal-title":"J. Neuropathol. Exp. Neurol."},{"issue":"Pt 1","key":"10.1016\/j.brainres.2018.08.014_b0140","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1042\/bj2750099","article-title":"Tau in Alzheimer's disease and Down's syndrome is insoluble and abnormally phosphorylated","volume":"275","author":"Hanger","year":"1991","journal-title":"Biochem. J."},{"issue":"51","key":"10.1016\/j.brainres.2018.08.014_b0150","doi-asserted-by":"crossref","first-page":"15157","DOI":"10.1021\/bi061850f","article-title":"Solution state characterization of amyloid beta-derived diffusible ligands","volume":"45","author":"Hepler","year":"2006","journal-title":"Biochemistry"},{"issue":"6","key":"10.1016\/j.brainres.2018.08.014_b0155","doi-asserted-by":"crossref","first-page":"925","DOI":"10.1212\/01.WNL.0000115115.98960.37","article-title":"Early Abeta accumulation and progressive synaptic loss, gliosis, and tangle formation in AD brain","volume":"62","author":"Ingelsson","year":"2004","journal-title":"Neurology"},{"issue":"1","key":"10.1016\/j.brainres.2018.08.014_b0160","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1007\/s00401-009-0486-3","article-title":"Mechanisms of tau-induced neurodegeneration","volume":"118","author":"Iqbal","year":"2009","journal-title":"Acta Neuropathol."},{"issue":"5","key":"10.1016\/j.brainres.2018.08.014_b0165","doi-asserted-by":"crossref","first-page":"2087","DOI":"10.1046\/j.1471-4159.1997.69052087.x","article-title":"A conformation- and phosphorylation-dependent antibody recognizing the paired helical filaments of Alzheimer's disease","volume":"69","author":"Jicha","year":"1997","journal-title":"J. Neurochem."},{"issue":"5","key":"10.1016\/j.brainres.2018.08.014_b0170","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1007\/s00401-017-1681-2","article-title":"Tau aggregation influences cognition and hippocampal atrophy in the absence of beta-amyloid: a clinico-imaging-pathological study of primary age-related tauopathy (PART)","volume":"133","author":"Josephs","year":"2017","journal-title":"Acta Neuropathol."},{"key":"10.1016\/j.brainres.2018.08.014_b0175","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1007\/978-1-61779-551-0_32","article-title":"Biochemical isolation of insoluble tau in transgenic mouse models of tauopathies","volume":"849","author":"Julien","year":"2012","journal-title":"Methods Mol. Biol. (Clifton, N.J.)"},{"key":"10.1016\/j.brainres.2018.08.014_b0185","doi-asserted-by":"crossref","DOI":"10.1186\/1750-1326-5-57","article-title":"Conformation dependent monoclonal antibodies distinguish different replicating strains or conformers of prefibrillar Abeta oligomers","volume":"5","author":"Kayed","year":"2010","journal-title":"Mol. Neurodegener."},{"issue":"4","key":"10.1016\/j.brainres.2018.08.014_b0190","first-page":"177","article-title":"Sequential changes of tau-site-specific phosphorylation during development of paired helical filaments","volume":"7","author":"Kimura","year":"1996","journal-title":"Dementia (Basel, Switzerland)"},{"issue":"6","key":"10.1016\/j.brainres.2018.08.014_b0195","doi-asserted-by":"crossref","first-page":"875","DOI":"10.1007\/s00401-016-1632-3","article-title":"Soluble pre-fibrillar tau and beta-amyloid species emerge in early human Alzheimer's disease and track disease progression and cognitive decline","volume":"132","author":"Koss","year":"2016","journal-title":"Acta Neuropathol."},{"issue":"2","key":"10.1016\/j.brainres.2018.08.014_b0200","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/0006-8993(92)91476-U","article-title":"Phosphate analysis and dephosphorylation of modified tau associated with paired helical filaments","volume":"597","author":"Ksiezak-Reding","year":"1992","journal-title":"Brain Res."},{"issue":"1","key":"10.1016\/j.brainres.2018.08.014_b0205","doi-asserted-by":"crossref","first-page":"510","DOI":"10.1073\/pnas.1318807111","article-title":"Neurofibrillary tangle-bearing neurons are functionally integrated in cortical circuits in vivo","volume":"111","author":"Kuchibhotla","year":"2014","journal-title":"PNAS"},{"issue":"2","key":"10.1016\/j.brainres.2018.08.014_b0210","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1042\/BJ20071499","article-title":"How do surfactants and DTT affect the size, dynamics, activity and growth of soluble lysozyme aggregates?","volume":"415","author":"Kumar","year":"2008","journal-title":"Biochem. J."},{"issue":"2\u20133","key":"10.1016\/j.brainres.2018.08.014_b0215","first-page":"167","article-title":"Pathways of tau fibrillization","volume":"1739","author":"Kuret","year":"2005","journal-title":"BBA"},{"issue":"31","key":"10.1016\/j.brainres.2018.08.014_b9000","doi-asserted-by":"crossref","first-page":"24228","DOI":"10.1074\/jbc.M110.133108","article-title":"Resveratrol selectively remodels soluble oligomers and fibrils of amyloid Abeta into off-pathway conformers","volume":"285","author":"Ladiwala","year":"2010","journal-title":"J. Biol. Chem."},{"issue":"5","key":"10.1016\/j.brainres.2018.08.014_b9005","doi-asserted-by":"crossref","first-page":"3209","DOI":"10.1074\/jbc.M110.173856","article-title":"Aromatic small molecules remodel toxic soluble oligomers of amyloid beta through three independent pathways","volume":"282","author":"Ladiwala","year":"2011","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.brainres.2018.08.014_b0220","doi-asserted-by":"crossref","DOI":"10.1186\/1750-1326-6-39","article-title":"Tau oligomers impair memory and induce synaptic and mitochondrial dysfunction in wild-type mice","volume":"6","author":"Lasagna-Reeves","year":"2011","journal-title":"Mol. Neurodegener."},{"issue":"5","key":"10.1016\/j.brainres.2018.08.014_b0225","doi-asserted-by":"crossref","first-page":"1946","DOI":"10.1096\/fj.11-199851","article-title":"Identification of oligomers at early stages of tau aggregation in Alzheimer's disease","volume":"26","author":"Lasagna-Reeves","year":"2012","journal-title":"FASEB J.: Off. Publ. Fed. Am. Soc. Exp. Biol."},{"issue":"2","key":"10.1016\/j.brainres.2018.08.014_b0230","doi-asserted-by":"crossref","first-page":"pp","DOI":"10.1042\/AN20090015","article-title":"Memory deficits in APP23\/Abca1+\/\u2212 mice correlate with the level of Abeta oligomers","volume":"1","author":"Lefterov","year":"2009","journal-title":"ASN neuro"},{"issue":"5","key":"10.1016\/j.brainres.2018.08.014_b9015","doi-asserted-by":"crossref","first-page":"e0126317","DOI":"10.1371\/journal.pone.0126317","article-title":"Characterization of a novel mouse model of Alzheimer's disease-amyloid pathology and unique beta-amyloid oligomer profile","volume":"10","author":"Liu","year":"2015","journal-title":"PloS One"},{"issue":"11","key":"10.1016\/j.brainres.2018.08.014_b0235","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0027291","article-title":"Alzheimer's disease and non-demented high pathology control nonagenarians: comparing and contrasting the biochemistry of cognitively successful aging","volume":"6","author":"Maarouf","year":"2011","journal-title":"PLoS One"},{"issue":"1","key":"10.1016\/j.brainres.2018.08.014_b0245","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1001\/archneur.63.1.38","article-title":"Neuropathologic substrate of mild cognitive impairment","volume":"63","author":"Markesbery","year":"2006","journal-title":"Arch. Neurol."},{"issue":"4","key":"10.1016\/j.brainres.2018.08.014_b0250","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1016\/j.neuint.2010.12.023","article-title":"Post-translational modifications of tau protein: implications for Alzheimer's disease","volume":"58","author":"Martin","year":"2011","journal-title":"Neurochem. Int."},{"issue":"4","key":"10.1016\/j.brainres.2018.08.014_b0255","doi-asserted-by":"crossref","first-page":"989","DOI":"10.1016\/0896-6273(94)90264-X","article-title":"Biopsy-derived adult human brain tau is phosphorylated at many of the same sites as Alzheimer's disease paired helical filament tau","volume":"13","author":"Matsuo","year":"1994","journal-title":"Neuron"},{"issue":"4","key":"10.1016\/j.brainres.2018.08.014_b0265","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1111\/bpa.12424","article-title":"TDP-43 pathology in Alzheimer's disease, dementia with Lewy bodies and ageing","volume":"27","author":"McAleese","year":"2017","journal-title":"Brain Pathol. (Zurich, Switzerland)"},{"issue":"Pt 1","key":"10.1016\/j.brainres.2018.08.014_b0270","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1093\/brain\/aws307","article-title":"The spectrum of disease in chronic traumatic encephalopathy","volume":"136","author":"McKee","year":"2013","journal-title":"Brain: A J. Neurol."},{"issue":"6","key":"10.1016\/j.brainres.2018.08.014_b0275","doi-asserted-by":"crossref","first-page":"860","DOI":"10.1002\/1531-8249(199912)46:6<860::AID-ANA8>3.0.CO;2-M","article-title":"Soluble pool of Abeta amyloid as a determinant of severity of neurodegeneration in Alzheimer's disease","volume":"46","author":"McLean","year":"1999","journal-title":"Ann. Neurol."},{"issue":"Pt 6","key":"10.1016\/j.brainres.2018.08.014_b0280","doi-asserted-by":"crossref","first-page":"1913","DOI":"10.1093\/brain\/awt088","article-title":"The influence of phospho-tau on dendritic spines of cortical pyramidal neurons in patients with Alzheimer's disease","volume":"136","author":"Merino-Serrais","year":"2013","journal-title":"Brain: A J. Neurol."},{"issue":"2","key":"10.1016\/j.brainres.2018.08.014_b0285","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1111\/nan.12084","article-title":"Phosphorylation of tau protein at sites Ser(396\u2013404) is one of the earliest events in Alzheimer's disease and Down syndrome","volume":"40","author":"Mondragon-Rodriguez","year":"2014","journal-title":"Neuropathol. Appl. Neurobiol."},{"key":"10.1016\/j.brainres.2018.08.014_b0290","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.neurobiolaging.2016.03.003","article-title":"Braak stage and trajectory of cognitive decline in noncognitively impaired elders","volume":"43","author":"Mufson","year":"2016","journal-title":"Neurobiol. Aging"},{"issue":"2","key":"10.1016\/j.brainres.2018.08.014_b0295","first-page":"565","article-title":"Biochemical and anatomical redistribution of tau protein in Alzheimer's disease","volume":"143","author":"Mukaetova-Ladinska","year":"1993","journal-title":"Am. J. Pathol."},{"issue":"12","key":"10.1016\/j.brainres.2018.08.014_b0300","doi-asserted-by":"crossref","first-page":"1571","DOI":"10.1001\/jama.283.12.1571","article-title":"Correlation between elevated levels of amyloid beta-peptide in the brain and cognitive decline","volume":"283","author":"Naslund","year":"2000","journal-title":"JAMA"},{"issue":"11","key":"10.1016\/j.brainres.2018.08.014_b0305","doi-asserted-by":"crossref","first-page":"2126","DOI":"10.1002\/pro.3275","article-title":"Amyloidogenesis of Tau protein","volume":"26","author":"Nizynski","year":"2017","journal-title":"Protein Sci.: A Publ. Protein Soc."},{"issue":"26","key":"10.1016\/j.brainres.2018.08.014_b0310","doi-asserted-by":"crossref","first-page":"23063","DOI":"10.1074\/jbc.M111.237974","article-title":"Characterization of prefibrillar Tau oligomers in vitro and in Alzheimer disease","volume":"286","author":"Patterson","year":"2011","journal-title":"J. Biol. Chem."},{"issue":"3","key":"10.1016\/j.brainres.2018.08.014_b0315","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1002\/1531-8249(199903)45:3<358::AID-ANA12>3.0.CO;2-X","article-title":"Tangles and plaques in nondemented aging and \u201cpreclinical\u201d Alzheimer's disease","volume":"45","author":"Price","year":"1999","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.brainres.2018.08.014_b0320","doi-asserted-by":"crossref","first-page":"14809","DOI":"10.1038\/srep14809","article-title":"SDS-PAGE analysis of Abeta oligomers is disserving research into Alzheimer s disease: appealing for ESI-IM-MS","volume":"5","author":"Pujol-Pina","year":"2015","journal-title":"Sci. Rep."},{"issue":"Pt 3","key":"10.1016\/j.brainres.2018.08.014_b0330","doi-asserted-by":"crossref","first-page":"887","DOI":"10.1093\/brain\/awt362","article-title":"Biochemical stages of amyloid-beta peptide aggregation and accumulation in the human brain and their association with symptomatic and pathologically preclinical Alzheimer's disease","volume":"137","author":"Rijal Upadhaya","year":"2014","journal-title":"Brain: A J. Neurol."},{"key":"10.1016\/j.brainres.2018.08.014_b0335","doi-asserted-by":"crossref","unstructured":"Rostagno, A. and Ghiso, J., 2009. Isolation and biochemical characterization of amyloid plaques and paired helical filaments. Current protocols in cell biology, Chapter 3, pp. Unit 3.33 3.33.1-33.","DOI":"10.1002\/0471143030.cb0333s44"},{"issue":"8","key":"10.1016\/j.brainres.2018.08.014_b0340","doi-asserted-by":"crossref","first-page":"2462","DOI":"10.1002\/anie.201409050","article-title":"Influence of the beta-sheet content on the mechanical properties of aggregates during amyloid fibrillization","volume":"54","author":"Ruggeri","year":"2015","journal-title":"Angewandte Chemie (International ed.in English)"},{"issue":"5733","key":"10.1016\/j.brainres.2018.08.014_b0350","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1126\/science.1113694","article-title":"Tau suppression in a neurodegenerative mouse model improves memory function","volume":"309","author":"Santacruz","year":"2005","journal-title":"Science (New York, N.Y.)"},{"issue":"1","key":"10.1016\/j.brainres.2018.08.014_b0355","first-page":"16","article-title":"Alzheimer's amyloid fibrils: structure and assembly","volume":"1502","author":"Serpell","year":"2000","journal-title":"BBA"},{"key":"10.1016\/j.brainres.2018.08.014_b0360","doi-asserted-by":"crossref","DOI":"10.1186\/1423-0127-19-104","article-title":"Keampferol-3-O-rhamnoside abrogates amyloid beta toxicity by modulating monomers and remodeling oligomers and fibrils to non-toxic aggregates","volume":"19","author":"Sharoar","year":"2012","journal-title":"J. Biomed. Sci."},{"issue":"2","key":"10.1016\/j.brainres.2018.08.014_b0365","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1007\/s00401-017-1709-7","article-title":"Interactions of pathological proteins in neurodegenerative diseases","volume":"134","author":"Spires-Jones","year":"2017","journal-title":"Acta Neuropathol."},{"issue":"12","key":"10.1016\/j.brainres.2018.08.014_b0370","doi-asserted-by":"crossref","first-page":"1791","DOI":"10.1212\/WNL.58.12.1791","article-title":"Phases of A beta-deposition in the human brain and its relevance for the development of AD","volume":"58","author":"Thal","year":"2002","journal-title":"Neurology"},{"issue":"Pt 10","key":"10.1016\/j.brainres.2018.08.014_b0375","doi-asserted-by":"crossref","first-page":"2969","DOI":"10.1093\/brain\/awr209","article-title":"Neurofibrillary tangle pathology and Braak staging in chronic epilepsy in relation to traumatic brain injury and hippocampal sclerosis: a post-mortem study","volume":"134","author":"Thom","year":"2011","journal-title":"Brain: A J. Neurol."},{"issue":"3","key":"10.1016\/j.brainres.2018.08.014_b0380","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1016\/j.nbd.2009.05.024","article-title":"Soluble fibrillar oligomer levels are elevated in Alzheimer's disease brain and correlate with cognitive dysfunction","volume":"35","author":"Tomic","year":"2009","journal-title":"Neurobiol. Dis."},{"issue":"4","key":"10.1016\/j.brainres.2018.08.014_b0385","doi-asserted-by":"crossref","first-page":"377","DOI":"10.3233\/JAD-2007-12411","article-title":"Biochemical characterization of Abeta and tau pathologies in mild cognitive impairment and Alzheimer's disease","volume":"12","author":"Tremblay","year":"2007","journal-title":"J. Alzheimer's Dis.: JAD"},{"issue":"23","key":"10.1016\/j.brainres.2018.08.014_b0390","doi-asserted-by":"crossref","first-page":"4088","DOI":"10.1016\/j.febslet.2012.10.022","article-title":"A comparative analysis of the aggregation behavior of amyloid-beta peptide variants","volume":"586","author":"Vandersteen","year":"2012","journal-title":"FEBS Lett."},{"issue":"5","key":"10.1016\/j.brainres.2018.08.014_b0395","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1007\/s00401-015-1406-3","article-title":"Neuropathologically mixed Alzheimer's and Lewy body disease: burden of pathological protein aggregates differs between clinical phenotypes","volume":"129","author":"Walker","year":"2015","journal-title":"Acta Neuropathol."},{"issue":"5","key":"10.1016\/j.brainres.2018.08.014_b0400","doi-asserted-by":"crossref","first-page":"1172","DOI":"10.1111\/j.1471-4159.2006.04426.x","article-title":"A beta oligomers \u2013 a decade of discovery","volume":"101","author":"Walsh","year":"2007","journal-title":"J. Neurochem."},{"issue":"2","key":"10.1016\/j.brainres.2018.08.014_b0405","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1006\/exnr.1999.7085","article-title":"The levels of soluble versus insoluble brain Abeta distinguish Alzheimer's disease from normal and pathologic aging","volume":"158","author":"Wang","year":"1999","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.brainres.2018.08.014_b0410","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.nbd.2014.03.002","article-title":"TOC1: a valuable tool in assessing disease progression in the rTg4510 mouse model of tauopathy","volume":"67","author":"Ward","year":"2014","journal-title":"Neurobiology of disease"},{"key":"10.1016\/j.brainres.2018.08.014_b0415","doi-asserted-by":"crossref","DOI":"10.1186\/1750-1326-7-8","article-title":"Intraneuronal Abeta detection in 5xFAD mice by a new Abeta-specific antibody","volume":"7","author":"Youmans","year":"2012","journal-title":"Mol. Neurodegener."},{"issue":"3","key":"10.1016\/j.brainres.2018.08.014_b0420","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1016\/j.nbd.2006.01.006","article-title":"Assessments of the accumulation severities of amyloid beta-protein and hyperphosphorylated tau in the medial temporal cortex of control and Alzheimer's brains","volume":"22","author":"Zhou","year":"2006","journal-title":"Neurobiol. Dis."}],"container-title":["Brain Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006899318304347?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006899318304347?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,7,9]],"date-time":"2024-07-09T04:03:21Z","timestamp":1720497801000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006899318304347"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,11]]},"references-count":77,"alternative-id":["S0006899318304347"],"URL":"https:\/\/doi.org\/10.1016\/j.brainres.2018.08.014","relation":{},"ISSN":["0006-8993"],"issn-type":[{"value":"0006-8993","type":"print"}],"subject":[],"published":{"date-parts":[[2018,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Distinctive temporal profiles of detergent-soluble and -insoluble tau and A\u03b2 species in human Alzheimer\u2019s disease","name":"articletitle","label":"Article Title"},{"value":"Brain Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.brainres.2018.08.014","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Crown Copyright \u00a9 2018 Published by Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}