{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T06:07:00Z","timestamp":1760854020926},"reference-count":31,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,3,1]],"date-time":"2019-03-01T00:00:00Z","timestamp":1551398400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,3,1]],"date-time":"2019-03-01T00:00:00Z","timestamp":1551398400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2019,3,1]],"date-time":"2019-03-01T00:00:00Z","timestamp":1551398400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2019,3,1]],"date-time":"2019-03-01T00:00:00Z","timestamp":1551398400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2019,3,1]],"date-time":"2019-03-01T00:00:00Z","timestamp":1551398400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2019,3,1]],"date-time":"2019-03-01T00:00:00Z","timestamp":1551398400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2019,3,1]],"date-time":"2019-03-01T00:00:00Z","timestamp":1551398400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"name":"Parkinson\u2019s UK","award":["G-1304"],"award-info":[{"award-number":["G-1304"]}]},{"name":"bet365\/Denise Coates Foundation"},{"name":"CONACYT, Mexico"}],"content-domain":{"domain":["clinicalkey.fr","clinicalkey.jp","clinicalkey.com.au","clinicalkey.es","clinicalkey.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Brain Research"],"published-print":{"date-parts":[[2019,3]]},"DOI":"10.1016\/j.brainres.2018.09.032","type":"journal-article","created":{"date-parts":[[2018,9,26]],"date-time":"2018-09-26T07:01:21Z","timestamp":1537945281000},"page":"218-223","update-policy":"http:\/\/dx.doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":9,"special_numbering":"C","title":["TIGAR inclusion pathology is specific for Lewy body diseases"],"prefix":"10.1016","volume":"1706","author":[{"given":"Karla L. Robles","family":"L\u00f3pez","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julie E.","family":"Simpson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lisa C","family":"Watson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Heather","family":"Mortiboys","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guillaume M.","family":"Hautbergue","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Oliver","family":"Bandmann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. Robin","family":"Highley","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.brainres.2018.09.032_b0010","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/S0969-2126(98)00006-9","article-title":"The mechanism of regulation of hexokinase: new insights from the crystal structure of recombinant human brain hexokinase complexed with glucose and glucose-6-phosphate","volume":"6","author":"Aleshin","year":"1998","journal-title":"Structure"},{"key":"10.1016\/j.brainres.2018.09.032_b0015","first-page":"879","article-title":"Aggregation of alpha-synuclein in Lewy bodies of sporadic Parkinson\u2019s disease and dementia with Lewy bodies","volume":"152","author":"Baba","year":"1998","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.brainres.2018.09.032_b0020","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/j.cell.2006.05.036","article-title":"TIGAR, a p53-inducible regulator of glycolysis and apoptosis","volume":"126","author":"Bensaad","year":"2006","journal-title":"Cell"},{"key":"10.1016\/j.brainres.2018.09.032_b0025","doi-asserted-by":"crossref","first-page":"3015","DOI":"10.1038\/emboj.2009.242","article-title":"Modulation of intracellular ROS levels by TIGAR controls autophagy","volume":"28","author":"Bensaad","year":"2009","journal-title":"EMBO J."},{"key":"10.1016\/j.brainres.2018.09.032_b0030","doi-asserted-by":"crossref","first-page":"724","DOI":"10.3390\/ijms10030724","article-title":"Molecular pathology of lewy body diseases","volume":"10","author":"Beyer","year":"2009","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.brainres.2018.09.032_b0035","article-title":"Persistent mitochondrial damage by nitric oxide and its derivatives: neuropathological implications","author":"Bola\u00f1os","year":"2010","journal-title":"Front. Neuroenergy"},{"key":"10.1016\/j.brainres.2018.09.032_b0040","doi-asserted-by":"crossref","first-page":"20491","DOI":"10.1073\/pnas.1206530109","article-title":"Mitochondrial localization of TIGAR under hypoxia stimulates HK2 and lowers ROS and cell death","volume":"109","author":"Cheung","year":"2012","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.brainres.2018.09.032_b0045","doi-asserted-by":"crossref","first-page":"1943","DOI":"10.1002\/jnr.22357","article-title":"Hexokinase II gene transfer protects against neurodegeneration in the rotenone and MPTP mouse models of Parkinson\u2019s disease","volume":"88","author":"Corona","year":"2010","journal-title":"J. Neurosci. Res."},{"key":"10.1016\/j.brainres.2018.09.032_b0055","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0082732","article-title":"\u03b1-synuclein oligomers induced by docosahexaenoic acid affect membrane integrity","author":"Fecchio","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.brainres.2018.09.032_b0060","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1002\/ana.23999","article-title":"TigarB causes mitochondrial dysfunction and neuronal loss in PINK1 deficiency","volume":"74","author":"Flinn","year":"2013","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.brainres.2018.09.032_b0065","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1007\/s004010050395","article-title":"Microtubule-associated protein 5 is a component of Lewy bodies and Lewy neurites in the brainstem and forebrain regions affected in Parkinson\u2019s disease","volume":"91","author":"Gai","year":"1996","journal-title":"Acta Neuropathol."},{"key":"10.1016\/j.brainres.2018.09.032_b0070","doi-asserted-by":"crossref","first-page":"3001","DOI":"10.1074\/jbc.M808698200","article-title":"Mitochondrial hexokinase II promotes neuronal survival and acts downstream of glycogen synthase kinase-3","volume":"284","author":"Gimenez-Cassina","year":"2009","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.brainres.2018.09.032_b0080","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1097\/00005072-199804000-00005","article-title":"Nigral and cortical Lewy bodies and dystrophic nigral neurites in Parkinson\u2019s disease and cortical Lewy body disease contain alpha-synuclein immunoreactivity","volume":"57","author":"Irizarry","year":"1998","journal-title":"J. Neuropathol. Exp. Neurol."},{"key":"10.1016\/j.brainres.2018.09.032_b0085","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/S1474-4422(16)30291-5","article-title":"Neuropathological and genetic correlates of survival and dementia onset in synucleinopathies: a retrospective analysis","volume":"16","author":"Irwin","year":"2017","journal-title":"Lancet Neurol."},{"key":"10.1016\/j.brainres.2018.09.032_b0090","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0017674","article-title":"Subcellular localization of hexokinases I and II directs the metabolic fate of glucose","author":"John","year":"2011","journal-title":"PLoS One"},{"key":"10.1016\/j.brainres.2018.09.032_b0095","doi-asserted-by":"crossref","DOI":"10.1371\/annotation\/59ecb64c-1f53-4d8a-903c-2f835e78bd13","article-title":"Cycle checkpoint abnormalities during dementia: a plausible association with the loss of protection against oxidative stress in Alzheimer\u2019s disease","volume":"8","author":"Katsel","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.brainres.2018.09.032_b0105","doi-asserted-by":"crossref","DOI":"10.1038\/cddis.2015.205","article-title":"p53-and p73-independent activation of TIGAR expression in vivo.","volume":"6","author":"Lee","year":"2015","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.brainres.2018.09.032_b0110","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.jprot.2009.07.007","article-title":"Proteomics in human Parkinson\u2019s disease research","volume":"73","author":"Licker","year":"2009","journal-title":"J. Proteomics"},{"key":"10.1016\/j.brainres.2018.09.032_b0115","doi-asserted-by":"crossref","DOI":"10.1038\/srep34802","article-title":"Hexokinase I N-terminal based peptide prevents the VDAC1-SOD1 G93A interaction and re-establishes ALS cell viability","author":"Magr\u00ec","year":"2016","journal-title":"Rep. Sci."},{"key":"10.1016\/j.brainres.2018.09.032_b0120","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1111\/neup.12204","article-title":"Isopentenyl diphosphate isomerase, a cholesterol synthesizing enzyme, is localized in Lewy bodies","volume":"35","author":"Nakamura","year":"2015","journal-title":"Neuropathology"},{"key":"10.1016\/j.brainres.2018.09.032_b0125","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1038\/nmeth.2019","article-title":"Fiji: an open-source platform for biological-image analysis","volume":"9","author":"Schindelin","year":"2012","journal-title":"Nat. Methods"},{"key":"10.1016\/j.brainres.2018.09.032_b0130","doi-asserted-by":"crossref","first-page":"1655","DOI":"10.1016\/S0002-9440(10)61113-3","article-title":"Parkin localizes to the Lewy bodies of Parkinson disease and dementia with Lewy bodies","volume":"160","author":"Schlossmacher","year":"2002","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.brainres.2018.09.032_b0135","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1006\/cgip.1994.1037","article-title":"Utilization of information measure as a means of image thresholding","volume":"56","author":"Shanbhag","year":"1994","journal-title":"CVGIP Graph. Model. Image Process."},{"key":"10.1016\/j.brainres.2018.09.032_b0140","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1038\/42166","article-title":"a-Synuclein in Lewy bodies","volume":"388","author":"Spillantini","year":"1997","journal-title":"Nature"},{"key":"10.1016\/j.brainres.2018.09.032_b0145","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/S0006-8993(00)02086-2","article-title":"Cyclin-dependent kinase 5 (Cdk5) associated with Lewy bodies in diffuse Lewy body disease","volume":"862","author":"Takahashi","year":"2000","journal-title":"Brain Res."},{"key":"10.1016\/j.brainres.2018.09.032_b0150","doi-asserted-by":"crossref","first-page":"963","DOI":"10.1080\/15548627.2015.1042195","article-title":"HK2\/hexokinase-II integrates glycolysis and autophagy to confer cellular protection","volume":"11","author":"Tan","year":"2015","journal-title":"Autophagy"},{"key":"10.1016\/j.brainres.2018.09.032_b0155","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1007\/s11910-010-0102-x","article-title":"The role of glucocerebrosidase mutations in Parkinson disease and Lewy body disorders","volume":"10","author":"Velayati","year":"2010","journal-title":"Curr. Neurol. Neurosci. Rep."},{"key":"10.1016\/j.brainres.2018.09.032_b0160","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1007\/s004010100451","article-title":"Immunocytochemical localization of synphilin-1, an \u03b1-synuclein-associated protein, in neurodegenerative disorders","volume":"103","author":"Wakabayashi","year":"2002","journal-title":"Acta Neuropathol."},{"key":"10.1016\/j.brainres.2018.09.032_b0165","doi-asserted-by":"crossref","DOI":"10.1007\/s12035-012-8280-y","article-title":"The Lewy body in Parkinson\u2019s disease and related neurodegenerative disorders","author":"Wakabayashi","year":"2013","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.brainres.2018.09.032_b0175","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1111\/j.1440-1789.2011.01200.x","article-title":"Accumulation of histone deacetylase 6, an aggresome-related protein, is specific to Lewy bodies and glial cytoplasmic inclusions","volume":"31","author":"Yasuo","year":"2011","journal-title":"Neuropathology"},{"key":"10.1016\/j.brainres.2018.09.032_b0180","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1016\/j.bbrc.2013.06.072","article-title":"Knockdown of TIGAR by RNA interference induces apoptosis and autophagy in HepG2 hepatocellular carcinoma cells","volume":"437","author":"Ye","year":"2013","journal-title":"Biochem. Biophys. Res. Commun."}],"container-title":["Brain Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006899318304979?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006899318304979?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,5,31]],"date-time":"2024-05-31T23:49:25Z","timestamp":1717199365000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006899318304979"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,3]]},"references-count":31,"alternative-id":["S0006899318304979"],"URL":"https:\/\/doi.org\/10.1016\/j.brainres.2018.09.032","relation":{},"ISSN":["0006-8993"],"issn-type":[{"value":"0006-8993","type":"print"}],"subject":[],"published":{"date-parts":[[2019,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"TIGAR inclusion pathology is specific for Lewy body diseases","name":"articletitle","label":"Article Title"},{"value":"Brain Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.brainres.2018.09.032","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}