{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T02:27:38Z","timestamp":1790735258445,"version":"4.1.0"},"reference-count":173,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,3,1]],"date-time":"2020-03-01T00:00:00Z","timestamp":1583020800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,3,1]],"date-time":"2020-03-01T00:00:00Z","timestamp":1583020800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100010232","name":"National Institute of Development Administration","doi-asserted-by":"publisher","award":["T32 DA007237"],"award-info":[{"award-number":["T32 DA007237"]}],"id":[{"id":"10.13039\/501100010232","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","award":["T32 NS007413"],"award-info":[{"award-number":["T32 NS007413"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Brain Research"],"published-print":{"date-parts":[[2020,3]]},"DOI":"10.1016\/j.brainres.2019.02.026","type":"journal-article","created":{"date-parts":[[2019,2,20]],"date-time":"2019-02-20T22:00:55Z","timestamp":1550700055000},"page":"146164","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":13,"special_numbering":"C","title":["Cocaine abuse and midbrain circuits: Functional anatomy of hypocretin\/orexin transmission and therapeutic prospect"],"prefix":"10.1016","volume":"1731","author":[{"given":"Steven J.","family":"Simmons","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taylor A.","family":"Gentile","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"31","key":"10.1016\/j.brainres.2019.02.026_b9000","doi-asserted-by":"crossref","first-page":"8228","DOI":"10.1523\/JNEUROSCI.1244-16.2016","article-title":"Reciprocal control of drinking behavior by median preoptic neurons in mice","volume":"36","author":"Abbott","year":"2016","journal-title":"J. Neurosci."},{"issue":"7","key":"10.1016\/j.brainres.2019.02.026_b0005","doi-asserted-by":"crossref","first-page":"1668","DOI":"10.1002\/cne.24158","article-title":"Descending projections from the basal forebrain to the orexin neurons in mice","volume":"525","author":"Agostinelli","year":"2017","journal-title":"J. Comp. Neurol."},{"issue":"5387","key":"10.1016\/j.brainres.2019.02.026_b0010","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1126\/science.282.5387.298","article-title":"Transition from moderate to excessive drug intake: change in hedonic set point","volume":"282","author":"Ahmed","year":"1998","journal-title":"Science"},{"issue":"1","key":"10.1016\/j.brainres.2019.02.026_b0015","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/j.bbr.2008.08.037","article-title":"Repeated intravenous amphetamine exposure: rapid and persistent sensitization of 50-kHz ultrasonic trill calls in rats","volume":"197","author":"Ahrens","year":"2009","journal-title":"Behav. Brain Res."},{"issue":"4","key":"10.1016\/j.brainres.2019.02.026_b0020","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1007\/s00213-013-3130-9","article-title":"Individual differences in the conditioned and unconditioned rat 50-kHz ultrasonic vocalizations elicited by repeated amphetamine exposure","volume":"229","author":"Ahrens","year":"2013","journal-title":"Psychopharmacology"},{"issue":"6356","key":"10.1016\/j.brainres.2019.02.026_b9005","doi-asserted-by":"crossref","first-page":"1149","DOI":"10.1126\/science.aan6747","article-title":"Thirst-associated preoptic neurons encode an aversive motivational drive","volume":"357","author":"Allen","year":"2017","journal-title":"Science"},{"issue":"8","key":"10.1016\/j.brainres.2019.02.026_b0025","doi-asserted-by":"crossref","first-page":"1501","DOI":"10.1007\/s00213-016-4247-4","article-title":"Ultrasonic vocalization in rats self-administering heroin and cocaine in different settings: evidence of substance-specific interactions between drug and setting","volume":"233","author":"Avvisati","year":"2016","journal-title":"Psychopharmacology"},{"issue":"6","key":"10.1016\/j.brainres.2019.02.026_b0030","doi-asserted-by":"crossref","first-page":"1346","DOI":"10.1016\/j.celrep.2017.01.030","article-title":"Projection-target-defined effects of orexin and dynorphin on VTA dopamine neurons","volume":"18","author":"Baimel","year":"2017","journal-title":"Cell Rep."},{"issue":"11","key":"10.1016\/j.brainres.2019.02.026_b0035","doi-asserted-by":"crossref","first-page":"1475","DOI":"10.1016\/0006-2952(64)90197-2","article-title":"The effects of cocaine, amphetamine and some amphetamine-like compounds on the in vivo levels of noradrenaline and dopamine in the rat brain","volume":"13","author":"Baird","year":"1964","journal-title":"Biochem. Pharmacol."},{"issue":"6","key":"10.1016\/j.brainres.2019.02.026_b0040","doi-asserted-by":"crossref","first-page":"1143","DOI":"10.1002\/cne.22561","article-title":"The inhibitory influence of the lateral habenula on midbrain dopamine cells: ultrastructural evidence for indirect mediation via the rostromedial mesopontine tegmental nucleus","volume":"519","author":"Balcita-Pedicino","year":"2011","journal-title":"J. Comp. Neurol."},{"issue":"2","key":"10.1016\/j.brainres.2019.02.026_b0045","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1002\/cne.10783","article-title":"Overlapping distributions of orexin\/hypocretin-and dopamine-\u03b2-hydroxylase immunoreactive fibers in rat brain regions mediating arousal, motivation, and stress","volume":"464","author":"Baldo","year":"2003","journal-title":"J. Comp. Neurol."},{"issue":"7","key":"10.1016\/j.brainres.2019.02.026_b0050","doi-asserted-by":"crossref","first-page":"1757","DOI":"10.1016\/j.celrep.2017.10.066","article-title":"Lateral preoptic control of the lateral habenula through convergent glutamate and GABA transmission","volume":"21","author":"Barker","year":"2017","journal-title":"Cell Rep."},{"issue":"4","key":"10.1016\/j.brainres.2019.02.026_b0055","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1007\/s00213-010-1913-9","article-title":"Dose-dependent differences in short ultrasonic vocalizations emitted by rats during cocaine self-administration","volume":"211","author":"Barker","year":"2010","journal-title":"Psychopharmacology"},{"issue":"2","key":"10.1016\/j.brainres.2019.02.026_b0060","doi-asserted-by":"crossref","first-page":"193","DOI":"10.2174\/1570159X13999150318113642","article-title":"Ultrasonic vocalizations as a measure of affect in preclinical models of drug abuse: a review of current findings","volume":"13","author":"Barker","year":"2015","journal-title":"Curr. Neuropharmacol."},{"issue":"5","key":"10.1016\/j.brainres.2019.02.026_b0065","doi-asserted-by":"crossref","first-page":"909","DOI":"10.1007\/s00213-013-3309-0","article-title":"Ultrasonic vocalizations: evidence for an affective opponent process during cocaine self-administration","volume":"231","author":"Barker","year":"2014","journal-title":"Psychopharmacology"},{"issue":"4","key":"10.1016\/j.brainres.2019.02.026_b0070","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1007\/BF02246021","article-title":"Withdrawal from oral cocaine in rats: ultrasonic vocalizations and tactile startle","volume":"125","author":"Barros","year":"1996","journal-title":"Psychopharmacology"},{"issue":"6","key":"10.1016\/j.brainres.2019.02.026_b0080","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1016\/S0091-6773(73)80115-4","article-title":"Hissing by laboratory rats during fighting encounters","volume":"8","author":"Berg","year":"1973","journal-title":"Behav. Biol."},{"issue":"5","key":"10.1016\/j.brainres.2019.02.026_b0085","doi-asserted-by":"crossref","first-page":"967","DOI":"10.1016\/0031-9384(91)90423-L","article-title":"Twenty-two kHz alarm cries to presentation of a predator, by laboratory rats living in visible burrow systems","volume":"50","author":"Blanchard","year":"1991","journal-title":"Physiol. Behav."},{"issue":"1","key":"10.1016\/j.brainres.2019.02.026_b0090","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1038\/s41593-017-0023-y","article-title":"Accumbal D2 cells orchestrate innate risk-avoidance according to orexin signals","volume":"21","author":"Blomeley","year":"2018","journal-title":"Nat. Neurosci."},{"issue":"36","key":"10.1016\/j.brainres.2019.02.026_b0095","doi-asserted-by":"crossref","first-page":"11215","DOI":"10.1523\/JNEUROSCI.6096-08.2009","article-title":"Orexin A\/hypocretin-1 selectively promotes motivation for positive reinforcers","volume":"29","author":"Borgland","year":"2009","journal-title":"J. Neurosci."},{"issue":"4","key":"10.1016\/j.brainres.2019.02.026_b0100","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1016\/j.neuron.2006.01.016","article-title":"Orexin A in the VTA is critical for the induction of synaptic plasticity and behavioral sensitization to cocaine","volume":"49","author":"Borgland","year":"2006","journal-title":"Neuron"},{"issue":"3","key":"10.1016\/j.brainres.2019.02.026_b0105","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1016\/j.yhbeh.2011.11.002","article-title":"Both oxytocin and vasopressin are mediators of maternal care and aggression in rodents: from central release to sites of action","volume":"61","author":"Bosch","year":"2012","journal-title":"Horm. Behav."},{"issue":"52","key":"10.1016\/j.brainres.2019.02.026_b0110","doi-asserted-by":"crossref","first-page":"19168","DOI":"10.1073\/pnas.0507480102","article-title":"Role for hypocretin in mediating stress-induced reinstatement of cocaine-seeking behavior","volume":"102","author":"Boutrel","year":"2005","journal-title":"PNAS"},{"issue":"3","key":"10.1016\/j.brainres.2019.02.026_b0115","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1016\/S0896-6273(00)80374-8","article-title":"Acute effects of cocaine on human brain activity and emotion","volume":"19","author":"Breiter","year":"1997","journal-title":"Neuron"},{"issue":"12","key":"10.1016\/j.brainres.2019.02.026_b0120","doi-asserted-by":"crossref","first-page":"4894","DOI":"10.1073\/pnas.0811507106","article-title":"Phasic excitation of dopamine neurons in ventral VTA by noxious stimuli","volume":"106","author":"Brischoux","year":"2009","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1016\/j.brainres.2019.02.026_b0125","article-title":"Hypocretin receptor 1 involvement in cocaine-associated behavior: therapeutic potential and novel mechanistic insights","author":"Brodnik","year":"2018","journal-title":"Brain Res."},{"issue":"1\u20132","key":"10.1016\/j.brainres.2019.02.026_b0130","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1016\/j.neuropharm.2011.04.012","article-title":"Positive affective vocalizations during cocaine and sucrose self-administration: a model for spontaneous drug desire in rats","volume":"61","author":"Browning","year":"2011","journal-title":"Neuropharmacology"},{"issue":"2","key":"10.1016\/j.brainres.2019.02.026_b0135","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/0031-9384(93)90102-L","article-title":"Analysis of 22 kHz ultrasonic vocalization in laboratory rats: long and short calls","volume":"54","author":"Brudzynski","year":"1993","journal-title":"Physiol. Behav."},{"issue":"4","key":"10.1016\/j.brainres.2019.02.026_b0140","first-page":"221","article-title":"Comparison between cholinergically and naturally induced ultrasonic vocalization in the rat","volume":"16","author":"Brudzynski","year":"1991","journal-title":"J. Psychiatry Neurosci."},{"issue":"12","key":"10.1016\/j.brainres.2019.02.026_b0145","doi-asserted-by":"crossref","first-page":"4951","DOI":"10.1523\/JNEUROSCI.23-12-04951.2003","article-title":"Orexin excites GABAergic neurons of the arcuate nucleus by activating the sodium\u2014calcium exchanger","volume":"23","author":"Burdakov","year":"2003","journal-title":"J. Neurosci."},{"key":"10.1016\/j.brainres.2019.02.026_b0150","doi-asserted-by":"crossref","first-page":"90","DOI":"10.3389\/fnsys.2015.00090","article-title":"Lateral hypothalamus, nucleus accumbens, and ventral pallidum roles in eating and hunger: interactions between homeostatic and reward circuitry","volume":"9","author":"Castro","year":"2015","journal-title":"Front. Syst. Neurosci."},{"key":"10.1016\/j.brainres.2019.02.026_b0155","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jchemneu.2015.03.002","article-title":"Distribution of the orexin-1 receptor (OX1R) in the mouse forebrain and rostral brainstem: a characterisation of OX1R-eGFP mice","volume":"66","author":"Ch\u2019ng","year":"2015","journal-title":"J. Chem. Neuroanat."},{"issue":"4","key":"10.1016\/j.brainres.2019.02.026_b0160","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1016\/S0092-8674(00)81973-X","article-title":"Narcolepsy in orexin knockout mice: molecular genetics of sleep regulation","volume":"98","author":"Chemelli","year":"1999","journal-title":"Cell"},{"key":"10.1016\/j.brainres.2019.02.026_b0165","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.psychres.2016.02.059","article-title":"Orexin-A level elevation in recently abstinent male methamphetamine abusers","volume":"239","author":"Chen","year":"2016","journal-title":"Psychiatry Res."},{"issue":"19","key":"10.1016\/j.brainres.2019.02.026_b0170","doi-asserted-by":"crossref","DOI":"10.1523\/JNEUROSCI.21-19-j0003.2001","article-title":"Orexin (hypocretin) neurons contain dynorphin","volume":"21","author":"Chou","year":"2001","journal-title":"J. Neurosci."},{"issue":"3","key":"10.1016\/j.brainres.2019.02.026_b0175","doi-asserted-by":"crossref","first-page":"977","DOI":"10.1523\/JNEUROSCI.22-03-00977.2002","article-title":"Afferents to the ventrolateral preoptic nucleus","volume":"22","author":"Chou","year":"2002","journal-title":"J. Neurosci."},{"key":"10.1016\/j.brainres.2019.02.026_b0180","article-title":"DeepSqueak: a deep learning-based system for detection and analysis of ultrasonic vocalizations","volume":"1","author":"Coffey","year":"2019","journal-title":"Neuropsychopharmacology"},{"issue":"1","key":"10.1016\/j.brainres.2019.02.026_b0185","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/0006-8993(80)90666-6","article-title":"Intracranial self-stimulation in relation to the ascending dopaminergic systems of the midbrain: a moveable electrode mapping study","volume":"185","author":"Corbett","year":"1980","journal-title":"Brain Res."},{"issue":"14","key":"10.1016\/j.brainres.2019.02.026_b0190","doi-asserted-by":"crossref","first-page":"5320","DOI":"10.1021\/jm100541c","article-title":"Discovery of the dual orexin receptor antagonist [(7 R)-4-(5-chloro-1, 3-benzoxazol-2-yl)-7-methyl-1, 4-diazepan-1-yl][5-methyl-2-(2 H-1, 2, 3-triazol-2-yl) phenyl] methanone (MK-4305) for the treatment of insomnia","volume":"53","author":"Cox","year":"2010","journal-title":"J. Med. Chem."},{"issue":"1","key":"10.1016\/j.brainres.2019.02.026_b0195","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1016\/j.neuron.2016.09.001","article-title":"Convergence of reinforcing and anhedonic cocaine effects in the ventral pallidum","volume":"92","author":"Creed","year":"2016","journal-title":"Neuron"},{"key":"10.1016\/j.brainres.2019.02.026_b0200","series-title":"Behavioral Neuroscience of Drug Addiction","first-page":"119","article-title":"Neural substrates of psychostimulant withdrawal-induced anhedonia","author":"D\u2019Souza","year":"2010"},{"issue":"1","key":"10.1016\/j.brainres.2019.02.026_b0205","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1073\/pnas.95.1.322","article-title":"The hypocretins: hypothalamus-specific peptides with neuroexcitatory activity","volume":"95","author":"De Lecea","year":"1998","journal-title":"Proc. Natl. Acad. Sci."},{"issue":"1","key":"10.1016\/j.brainres.2019.02.026_b0210","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1111\/j.1369-1600.2008.00129.x","article-title":"Impulsivity as a determinant and consequence of drug use: a review of underlying processes","volume":"14","author":"De Wit","year":"2009","journal-title":"Addict. Biol."},{"issue":"14","key":"10.1016\/j.brainres.2019.02.026_b0215","doi-asserted-by":"crossref","first-page":"5274","DOI":"10.1073\/pnas.85.14.5274","article-title":"Drugs abused by humans preferentially increase synaptic dopamine concentrations in the mesolimbic system of freely moving rats","volume":"85","author":"Di Chiara","year":"1988","journal-title":"Proc. Natl. Acad. Sci."},{"issue":"1","key":"10.1016\/j.brainres.2019.02.026_b0220","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1901\/jeab.1973.20-111","article-title":"Fixed-interval schedules of intravenous cocaine presentation in rats 1","volume":"20","author":"Dougherty","year":"1973","journal-title":"J. Exp. Anal. Behav."},{"issue":"23","key":"10.1016\/j.brainres.2019.02.026_b0225","doi-asserted-by":"crossref","first-page":"9273","DOI":"10.1523\/JNEUROSCI.21-23-09273.2001","article-title":"Orexin\/hypocretin excites the histaminergic neurons of the tuberomammillary nucleus","volume":"21","author":"Eriksson","year":"2001","journal-title":"J. Neurosci."},{"issue":"4","key":"10.1016\/j.brainres.2019.02.026_b9010","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1016\/S0306-4522(01)00319-0","article-title":"Wake-promoting and sleep-suppressing actions of hypocretin (orexin): basal forebrain sites of action","volume":"106","author":"Espa\u00f1a","year":"2001","journal-title":"Neuroscience"},{"issue":"2","key":"10.1016\/j.brainres.2019.02.026_b0230","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1007\/s00213-010-2048-8","article-title":"Hypocretin 1\/orexin A in the ventral tegmental area enhances dopamine responses to cocaine and promotes cocaine self-administration","volume":"214","author":"Espa\u00f1a","year":"2011","journal-title":"Psychopharmacology"},{"issue":"2","key":"10.1016\/j.brainres.2019.02.026_b0235","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1111\/j.1460-9568.2009.07065.x","article-title":"The hypocretin\u2013orexin system regulates cocaine self-administration via actions on the mesolimbic dopamine system","volume":"31","author":"Espa\u00f1a","year":"2010","journal-title":"Eur. J. Neurosci."},{"issue":"4","key":"10.1016\/j.brainres.2019.02.026_b9015","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1016\/0091-3057(78)90082-5","article-title":"Cocaine: Acute effects of reinforcement thresholds for self-stimulation behavior to the medial forebrain bundle","volume":"8","author":"Esposito","year":"1978","journal-title":"Pharmacol. Biochem. Behav."},{"issue":"5","key":"10.1016\/j.brainres.2019.02.026_b0245","doi-asserted-by":"crossref","first-page":"1656","DOI":"10.1523\/JNEUROSCI.21-05-01656.2001","article-title":"Fos expression in orexin neurons varies with behavioral state","volume":"21","author":"Estabrooke","year":"2001","journal-title":"J. Neurosci."},{"issue":"3","key":"10.1016\/j.brainres.2019.02.026_b9020","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1016\/S0091-3057(99)00109-4","article-title":"Evidence for opponent-process actions of intravenous cocaine","volume":"64","author":"Ettenberg","year":"1999","journal-title":"Pharmacol. Biochem. Behav."},{"issue":"4","key":"10.1016\/j.brainres.2019.02.026_b0250","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1007\/PL00005481","article-title":"Varieties of impulsivity","volume":"146","author":"Evenden","year":"1999","journal-title":"Psychopharmacology"},{"issue":"2","key":"10.1016\/j.brainres.2019.02.026_b0255","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1016\/S0306-4522(02)00017-9","article-title":"Anatomical substrates of orexin\u2013dopamine interactions: lateral hypothalamic projections to the ventral tegmental area","volume":"111","author":"Fadel","year":"2002","journal-title":"Neuroscience"},{"issue":"1","key":"10.1016\/j.brainres.2019.02.026_b0260","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1038\/s41467-018-03125-y","article-title":"Opponent control of behavioral reinforcement by inhibitory and excitatory projections from the ventral pallidum","volume":"9","author":"Faget","year":"2018","journal-title":"Nat. Commun."},{"key":"10.1016\/j.brainres.2019.02.026_b0265","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1016\/j.bbr.2018.08.021","article-title":"Involvement of orexinergic receptors in the nucleus accumbens, in the effect of forced swim stress on the reinstatement of morphine seeking behaviors","volume":"356","author":"Farzinpour","year":"2019","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.brainres.2019.02.026_b9025","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1016\/j.drugalcdep.2018.04.018","article-title":"Hypocretin\/orexin antagonists decrease cocaine self-administration by female rhesus monkeys","volume":"188","author":"Foltin","year":"2018","journal-title":"Drug Alcohol Depend."},{"issue":"16","key":"10.1016\/j.brainres.2019.02.026_b0270","doi-asserted-by":"crossref","first-page":"8733","DOI":"10.1073\/pnas.93.16.8733","article-title":"Overview of the most prevalent hypothalamus-specific mRNAs, as identified by directional tag PCR subtraction","volume":"93","author":"Gautvik","year":"1996","journal-title":"Proc. Natl. Acad. Sci."},{"issue":"4","key":"10.1016\/j.brainres.2019.02.026_b0275","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1016\/j.cub.2017.12.050","article-title":"Excitatory pathways from the lateral habenula enable propofol-induced sedation","volume":"28","author":"Gelegen","year":"2018","journal-title":"Curr. Biol."},{"issue":"1","key":"10.1016\/j.brainres.2019.02.026_b0280","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1111\/adb.12507","article-title":"Suvorexant, an orexin\/hypocretin receptor antagonist, attenuates motivational and hedonic properties of cocaine","volume":"23","author":"Gentile","year":"2018","journal-title":"Addict. Biol."},{"key":"10.1016\/j.brainres.2019.02.026_b0285","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/B978-0-12-803750-8.00024-5","article-title":"Hypocretin (Orexin) in models of cocaine addiction","author":"Gentile","year":"2017","journal-title":"Neurosci. Cocaine"},{"key":"10.1016\/j.brainres.2019.02.026_b0290","article-title":"Effects of suvorexant, a dual orexin\/hypocretin receptor antagonist, on impulsive behavior associated with cocaine","author":"Gentile","year":"2017","journal-title":"Neuropsychopharmacology"},{"issue":"19","key":"10.1016\/j.brainres.2019.02.026_b0295","doi-asserted-by":"crossref","first-page":"7239","DOI":"10.1523\/JNEUROSCI.23-19-07239.2003","article-title":"Persistent cue-evoked activity of accumbens neurons after prolonged abstinence from self-administered cocaine","volume":"23","author":"Ghitza","year":"2003","journal-title":"J. Neurosci."},{"issue":"9","key":"10.1016\/j.brainres.2019.02.026_b9030","doi-asserted-by":"crossref","first-page":"1029","DOI":"10.1037\/h0077187","article-title":"Effects of d-versus l-amphetamine, food deprivation, and current intensity on self-stimulation of the lateral hypothalamus, substantia nigra, & medial frontal cortex of the rat","volume":"89","author":"Goodall","year":"1975","journal-title":"J. Comp. Physiol. Psychol."},{"issue":"1","key":"10.1016\/j.brainres.2019.02.026_b0300","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1111\/j.1460-9568.2005.04538.x","article-title":"LTP in the lateral amygdala during cocaine withdrawal","volume":"23","author":"Goussakov","year":"2006","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.brainres.2019.02.026_b0305","doi-asserted-by":"crossref","DOI":"10.1523\/ENEURO.0273-17.2018","article-title":"Reduced orexin system function contributes to resilience to repeated social stress","author":"Grafe","year":"2018","journal-title":"eNeuro"},{"issue":"4","key":"10.1016\/j.brainres.2019.02.026_b0310","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1016\/S0306-4522(02)00877-1","article-title":"Orexin A (hypocretin-1) application at the medial preoptic area potentiates male sexual behavior in rats","volume":"116","author":"Gulia","year":"2003","journal-title":"Neuroscience"},{"issue":"19","key":"10.1016\/j.brainres.2019.02.026_b0315","doi-asserted-by":"crossref","first-page":"10911","DOI":"10.1073\/pnas.96.19.10911","article-title":"Orexin A activates locus coeruleus cell firing and increases arousal in the rat","volume":"96","author":"Hagan","year":"1999","journal-title":"Proc. Natl. Acad. Sci."},{"issue":"3","key":"10.1016\/j.brainres.2019.02.026_b0320","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1016\/j.neuroscience.2007.11.018","article-title":"Renewal of extinguished cocaine-seeking","volume":"151","author":"Hamlin","year":"2008","journal-title":"Neuroscience"},{"issue":"7058","key":"10.1016\/j.brainres.2019.02.026_b0325","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1038\/nature04071","article-title":"A role for lateral hypothalamic orexin neurons in reward seeking","volume":"437","author":"Harris","year":"2005","journal-title":"Nature"},{"issue":"9","key":"10.1016\/j.brainres.2019.02.026_b0330","doi-asserted-by":"crossref","first-page":"1655","DOI":"10.1038\/npp.2013.62","article-title":"An orexin hotspot in ventral pallidum amplifies hedonic \u2018liking\u2019 for sweetness","volume":"38","author":"Ho","year":"2013","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.brainres.2019.02.026_b0335","doi-asserted-by":"crossref","first-page":"47","DOI":"10.3389\/fnbeh.2012.00047","article-title":"Hypocretin-1 receptors regulate the reinforcing and reward-enhancing effects of cocaine: pharmacological and behavioral genetics evidence","volume":"6","author":"Hollander","year":"2012","journal-title":"Front. Behav. Neurosci."},{"issue":"1","key":"10.1016\/j.brainres.2019.02.026_b0340","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.yhbeh.2007.03.030","article-title":"Sexual behavior in male rodents","volume":"52","author":"Hull","year":"2007","journal-title":"Horm. Behav."},{"issue":"2","key":"10.1016\/j.brainres.2019.02.026_b0345","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1097\/FBP.0b013e328343d761","article-title":"Orexin-1 receptor antagonist SB-334867 reduces the acquisition and expression of cocaine-conditioned reinforcement and the expression of amphetamine-conditioned reward","volume":"22","author":"Hutcheson","year":"2011","journal-title":"Behav. Pharmacol."},{"issue":"5","key":"10.1016\/j.brainres.2019.02.026_b0350","doi-asserted-by":"crossref","first-page":"684","DOI":"10.1017\/S1461145711000423","article-title":"Orexin-1 receptor signalling within the ventral tegmental area, but not the paraventricular thalamus, is critical to regulating cue-induced reinstatement of cocaine-seeking","volume":"14","author":"James","year":"2011","journal-title":"Int. J. Neuropsychopharmacol."},{"key":"10.1016\/j.brainres.2019.02.026_b0355","series-title":"Behavioral Neuroscience of Orexin\/Hypocretin","first-page":"247","article-title":"A decade of orexin\/hypocretin and addiction: where are we now?","author":"James","year":"2016"},{"issue":"1","key":"10.1016\/j.brainres.2019.02.026_b0360","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1016\/j.neuron.2016.09.042","article-title":"The ventral pallidum: proposed integrator of positive and negative factors in cocaine abuse","volume":"92","author":"James","year":"2016","journal-title":"Neuron"},{"key":"10.1016\/j.brainres.2019.02.026_b0365","article-title":"Increased number and activity of a lateral subpopulation of hypothalamic orexin\/hypocretin neurons underlies the expression of an addicted state in rats","author":"James","year":"2018","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.brainres.2019.02.026_b0370","article-title":"Demand elasticity predicts addiction endophenotypes and the therapeutic efficacy of an orexin\/hypocretin-1 receptor antagonist in rats","author":"James","year":"2018","journal-title":"Eur. J. Neurosci."},{"issue":"6","key":"10.1016\/j.brainres.2019.02.026_b0375","doi-asserted-by":"crossref","first-page":"566","DOI":"10.1002\/cne.21891","article-title":"The mesopontine rostromedial tegmental nucleus: a structure targeted by the lateral habenula that projects to the ventral tegmental area of Tsai and substantia nigra compacta","volume":"513","author":"Jhou","year":"2009","journal-title":"J. Comp. Neurol."},{"issue":"17","key":"10.1016\/j.brainres.2019.02.026_b0380","doi-asserted-by":"crossref","first-page":"7501","DOI":"10.1523\/JNEUROSCI.3634-12.2013","article-title":"Cocaine drives aversive conditioning via delayed activation of dopamine-responsive habenular and midbrain pathways","volume":"33","author":"Jhou","year":"2013","journal-title":"J. Neurosci."},{"issue":"8","key":"10.1016\/j.brainres.2019.02.026_b0385","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1007\/s40263-014-0179-x","article-title":"Orexin\/hypocretin based pharmacotherapies for the treatment of addiction: DORA or SORA?","volume":"28","author":"Khoo","year":"2014","journal-title":"CNS Drugs"},{"issue":"3","key":"10.1016\/j.brainres.2019.02.026_b0395","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1016\/0091-3057(90)90242-A","article-title":"Postcocaine depression and sensitization of brain-stimulation reward: analysis of reinforcement and performance effects","volume":"36","author":"Kokkinidis","year":"1990","journal-title":"Pharmacol. Biochem. Behav."},{"issue":"4","key":"10.1016\/j.brainres.2019.02.026_b0400","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1016\/j.conb.2013.03.011","article-title":"Negative reinforcement in drug addiction: the darkness within","volume":"23","author":"Koob","year":"2013","journal-title":"Curr. Opin. Neurobiol."},{"issue":"1","key":"10.1016\/j.brainres.2019.02.026_b0405","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1523\/JNEUROSCI.23-01-00007.2003","article-title":"Excitation of ventral tegmental area dopaminergic and nondopaminergic neurons by orexins\/hypocretins","volume":"23","author":"Korotkova","year":"2003","journal-title":"J. Neurosci."},{"key":"10.1016\/j.brainres.2019.02.026_b0410","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1016\/j.biochi.2013.06.015","article-title":"Lipid signaling cascades of orexin\/hypocretin receptors","volume":"96","author":"Kukkonen","year":"2014","journal-title":"Biochimie"},{"key":"10.1016\/j.brainres.2019.02.026_b0415","series-title":"Behavioral Neuroscience of Orexin\/Hypocretin","first-page":"17","article-title":"Orexin\/hypocretin signaling","author":"Kukkonen","year":"2016"},{"key":"10.1016\/j.brainres.2019.02.026_b0420","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/j.brainres.2008.07.115","article-title":"Inactivation of median preoptic nucleus causes c-Fos expression in hypocretin-and serotonin-containing neurons in anesthetized rat","volume":"1234","author":"Kumar","year":"2008","journal-title":"Brain Res."},{"issue":"2","key":"10.1016\/j.brainres.2019.02.026_b0425","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1016\/j.neuron.2014.12.036","article-title":"Diversity of transgenic mouse models for selective targeting of midbrain dopamine neurons","volume":"85","author":"Lammel","year":"2015","journal-title":"Neuron"},{"issue":"50","key":"10.1016\/j.brainres.2019.02.026_b0430","doi-asserted-by":"crossref","first-page":"13037","DOI":"10.1523\/JNEUROSCI.3380-06.2006","article-title":"Differential target-dependent actions of coexpressed inhibitory dynorphin and excitatory hypocretin\/orexin neuropeptides","volume":"26","author":"Li","year":"2006","journal-title":"J. Neurosci."},{"issue":"3","key":"10.1016\/j.brainres.2019.02.026_b0435","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1016\/S0092-8674(00)81965-0","article-title":"The sleep disorder canine narcolepsy is caused by a mutation in the hypocretin (orexin) receptor 2 gene","volume":"98","author":"Lin","year":"1999","journal-title":"Cell"},{"issue":"2","key":"10.1016\/j.brainres.2019.02.026_b0440","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1016\/j.bbr.2006.11.038","article-title":"Rat 22 kHz ultrasonic vocalizations as alarm cries","volume":"182","author":"Litvin","year":"2007","journal-title":"Behav. Brain Res."},{"issue":"1","key":"10.1016\/j.brainres.2019.02.026_b0445","doi-asserted-by":"crossref","first-page":"1576","DOI":"10.1038\/s41467-018-03889-3","article-title":"Nucleus accumbens controls wakefulness by a subpopulation of neurons expressing dopamine D 1 receptors","volume":"9","author":"Luo","year":"2018","journal-title":"Nat. Commun."},{"key":"10.1016\/j.brainres.2019.02.026_b0450","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/j.smrv.2016.03.002","article-title":"Not a single but multiple populations of GABAergic neurons control sleep","volume":"32","author":"Luppi","year":"2017","journal-title":"Sleep Med. Rev."},{"issue":"4","key":"10.1016\/j.brainres.2019.02.026_b0455","doi-asserted-by":"crossref","first-page":"1141","DOI":"10.1007\/s00213-011-2445-7","article-title":"The missing variable: ultrasonic vocalizations reveal hidden sensitization and tolerance-like effects during long-term cocaine administration","volume":"219","author":"Maier","year":"2012","journal-title":"Psychopharmacology"},{"issue":"4","key":"10.1016\/j.brainres.2019.02.026_b0460","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1038\/nn.3664","article-title":"Designer receptors show role for ventral pallidum input to ventral tegmental area in cocaine seeking","volume":"17","author":"Mahler","year":"2014","journal-title":"Nat. Neurosci."},{"issue":"1","key":"10.1016\/j.brainres.2019.02.026_b0465","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1002\/cne.1190","article-title":"Differential expression of orexin receptors 1 and 2 in the rat brain","volume":"435","author":"Marcus","year":"2001","journal-title":"J. Comp. Neurol."},{"issue":"7148","key":"10.1016\/j.brainres.2019.02.026_b0470","doi-asserted-by":"crossref","first-page":"1111","DOI":"10.1038\/nature05860","article-title":"Lateral habenula as a source of negative reward signals in dopamine neurons","volume":"447","author":"Matsumoto","year":"2007","journal-title":"Nature"},{"issue":"5","key":"10.1016\/j.brainres.2019.02.026_b9035","doi-asserted-by":"crossref","first-page":"1010","DOI":"10.1038\/npp.2017.250","article-title":"Dynorphin counteracts orexin in the paraventricular nucleus of the thalamus: cellular and behavioral evidence","volume":"43","author":"Matzeu","year":"2018","journal-title":"Neuropsychopharmacology"},{"issue":"9","key":"10.1016\/j.brainres.2019.02.026_b0475","doi-asserted-by":"crossref","first-page":"1361","DOI":"10.5665\/sleep.4970","article-title":"Promotion of wakefulness and energy expenditure by orexin-A in the ventrolateral preoptic area","volume":"38","author":"Mavanji","year":"2015","journal-title":"Sleep"},{"issue":"3","key":"10.1016\/j.brainres.2019.02.026_b0480","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1038\/nn.4487","article-title":"Hormonal gain control of a medial preoptic area social reward circuit","volume":"20","author":"McHenry","year":"2017","journal-title":"Nat. Neurosci."},{"issue":"6","key":"10.1016\/j.brainres.2019.02.026_b0485","doi-asserted-by":"crossref","first-page":"1100","DOI":"10.1037\/0735-7044.98.6.1100","article-title":"Electrophysiological and ultrasonic correlates of reproductive behavior in the male rat","volume":"98","author":"McIntosh","year":"1984","journal-title":"Behav. Neurosci."},{"issue":"16","key":"10.1016\/j.brainres.2019.02.026_b0490","doi-asserted-by":"crossref","first-page":"3423","DOI":"10.1097\/00001756-200011090-00004","article-title":"Effects of lateral preoptic area application of orexin-A on sleep\u2013wakefulness","volume":"11","author":"Methippara","year":"2000","journal-title":"NeuroReport"},{"issue":"5","key":"10.1016\/j.brainres.2019.02.026_b0495","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1016\/S1474-4422(14)70053-5","article-title":"Safety and efficacy of suvorexant during 1-year treatment of insomnia with subsequent abrupt treatment discontinuation: a phase 3 randomised, double-blind, placebo-controlled trial","volume":"13","author":"Michelson","year":"2014","journal-title":"Lancet Neurol."},{"issue":"6564","key":"10.1016\/j.brainres.2019.02.026_b0500","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1038\/379449a0","article-title":"Preferential activation of midbrain dopamine neurons by appetitive rather than aversive stimuli","volume":"379","author":"Mirenowicz","year":"1996","journal-title":"Nature"},{"issue":"46","key":"10.1016\/j.brainres.2019.02.026_b0505","doi-asserted-by":"crossref","first-page":"15585","DOI":"10.1523\/JNEUROSCI.2871-10.2010","article-title":"Orexin\/hypocretin modulates response of ventral tegmental dopamine neurons to prefrontal activation: diurnal influences","volume":"30","author":"Moorman","year":"2010","journal-title":"J. Neurosci."},{"issue":"2","key":"10.1016\/j.brainres.2019.02.026_b9040","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1038\/nrn.2016.165","article-title":"Ventral tegmental area: cellular heterogeneity, connectivity and behaviour","volume":"18","author":"Morales","year":"2017","journal-title":"Nat. Rev. Neurosci."},{"issue":"1","key":"10.1016\/j.brainres.2019.02.026_b0510","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.neulet.2009.02.007","article-title":"Repeated cocaine exposure induces sensitization of ultrasonic vocalization in rats","volume":"453","author":"Mu","year":"2009","journal-title":"Neurosci. Lett."},{"issue":"1","key":"10.1016\/j.brainres.2019.02.026_b0515","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/0006-8993(82)91123-4","article-title":"Drug reinforcement studied by the use of place conditioning in rat","volume":"243","author":"Mucha","year":"1982","journal-title":"Brain Res."},{"issue":"11","key":"10.1016\/j.brainres.2019.02.026_b0520","doi-asserted-by":"crossref","first-page":"2837","DOI":"10.1523\/JNEUROSCI.4121-06.2007","article-title":"A role for hypocretin (orexin) in male sexual behavior","volume":"27","author":"Muschamp","year":"2007","journal-title":"J. Neurosci."},{"issue":"16","key":"10.1016\/j.brainres.2019.02.026_b0525","doi-asserted-by":"crossref","first-page":"E1648","DOI":"10.1073\/pnas.1315542111","article-title":"Hypocretin (orexin) facilitates reward by attenuating the antireward effects of its cotransmitter dynorphin in ventral tegmental area","volume":"111","author":"Muschamp","year":"2014","journal-title":"Proc. Natl. Acad. Sci."},{"issue":"2","key":"10.1016\/j.brainres.2019.02.026_b0530","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1007\/s002130050497","article-title":"Withdrawal from IV cocaine \u201cbinges\u201d in rats: ultrasonic distress calls and startle","volume":"135","author":"Mutschler","year":"1998","journal-title":"Psychopharmacology"},{"issue":"4","key":"10.1016\/j.brainres.2019.02.026_b0535","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1007\/s002130050584","article-title":"Withdrawal from a self-administered or non-contingent cocaine binge: differences in ultrasonic distress vocalizations in rats","volume":"136","author":"Mutschler","year":"1998","journal-title":"Psychopharmacology"},{"issue":"2","key":"10.1016\/j.brainres.2019.02.026_b9045","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1523\/JNEUROSCI.2761-05.2006","article-title":"Direct involvement of orexinergic systems in the activation of the mesolimbic dopamine pathway and related behaviors induced by morphine","volume":"26","author":"Narita","year":"2006","journal-title":"J. Neurosci."},{"issue":"6","key":"10.1016\/j.brainres.2019.02.026_b0540","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1037\/h0058775","article-title":"Positive reinforcement produced by electrical stimulation of septal area and other regions of rat brain","volume":"47","author":"Olds","year":"1954","journal-title":"J. Comp. Physiol. Psychol."},{"issue":"2","key":"10.1016\/j.brainres.2019.02.026_b0545","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1007\/s00213-010-2058-6","article-title":"A novel IV cocaine self-administration procedure in rats: differential effects of dopamine, serotonin, and GABA drug pre-treatments on cocaine consumption and maximal price paid","volume":"214","author":"Oleson","year":"2011","journal-title":"Psychopharmacology"},{"issue":"1","key":"10.1016\/j.brainres.2019.02.026_b0550","doi-asserted-by":"crossref","first-page":"4350","DOI":"10.1038\/s41467-018-06849-z","article-title":"Ventral pallidum encodes relative reward value earlier and more robustly than nucleus accumbens","volume":"9","author":"Ottenheimer","year":"2018","journal-title":"Nat. Commun."},{"issue":"33","key":"10.1016\/j.brainres.2019.02.026_b0555","doi-asserted-by":"crossref","first-page":"11957","DOI":"10.1073\/pnas.0803896105","article-title":"Dynamic changes in accumbens dopamine correlate with learning during intracranial self-stimulation","volume":"105","author":"Owesson-White","year":"2008","journal-title":"Proc. Natl. Acad. Sci."},{"issue":"1","key":"10.1016\/j.brainres.2019.02.026_b0560","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/S0166-4328(00)00238-2","article-title":"50-kHz chirping (laughter?) in response to conditioned and unconditioned tickle-induced reward in rats: effects of social housing and genetic variables","volume":"115","author":"Panksepp","year":"2000","journal-title":"Behav. Brain Res."},{"issue":"4","key":"10.1016\/j.brainres.2019.02.026_b0565","doi-asserted-by":"crossref","first-page":"899","DOI":"10.1016\/0091-3057(89)90291-8","article-title":"Dopamine in the nucleus accumbens during cocaine self-administration as studied by in vivo microdialysis","volume":"34","author":"Pettit","year":"1989","journal-title":"Pharmacol. Biochem. Behav."},{"issue":"23","key":"10.1016\/j.brainres.2019.02.026_b0570","doi-asserted-by":"crossref","first-page":"9996","DOI":"10.1523\/JNEUROSCI.18-23-09996.1998","article-title":"Neurons containing hypocretin (orexin) project to multiple neuronal systems","volume":"18","author":"Peyron","year":"1998","journal-title":"J. Neurosci."},{"key":"10.1016\/j.brainres.2019.02.026_b0575","doi-asserted-by":"crossref","DOI":"10.1111\/ejn.13879","article-title":"Synaptic function and plasticity in identified inhibitory inputs onto VTA dopamine neurons","author":"Polter","year":"2018","journal-title":"Eur. J. Neurosci."},{"issue":"1","key":"10.1016\/j.brainres.2019.02.026_b9050","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1021\/cn500246j","article-title":"Hypocretin\/Orexin regulation of dopamine signaling and cocaine self-administration is mediated predominantly by hypocretin receptor 1","volume":"6","author":"Prince","year":"2014","journal-title":"ACS Chem. Neurosci."},{"issue":"1","key":"10.1016\/j.brainres.2019.02.026_b0580","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/0165-0270(95)00153-0","article-title":"Progressive ratio schedules in drug self-administration studies in rats: a method to evaluate reinforcing efficacy","volume":"66","author":"Richardson","year":"1996","journal-title":"J. Neurosci. Methods"},{"key":"10.1016\/j.brainres.2019.02.026_b0585","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.peptides.2016.04.002","article-title":"Hypocretinergic system in the medial preoptic area promotes maternal behavior in lactating rats","volume":"81","author":"Rivas","year":"2016","journal-title":"Peptides"},{"issue":"9","key":"10.1016\/j.brainres.2019.02.026_b0590","doi-asserted-by":"crossref","first-page":"704","DOI":"10.1002\/syn.20792","article-title":"Rapid phasic activity of ventral pallidal neurons during cocaine self-administration","volume":"64","author":"Root","year":"2010","journal-title":"Synapse"},{"issue":"3","key":"10.1016\/j.brainres.2019.02.026_b0595","doi-asserted-by":"crossref","first-page":"558","DOI":"10.1002\/cne.23191","article-title":"Differential roles of ventral pallidum subregions during cocaine self-administration behaviors","volume":"521","author":"Root","year":"2013","journal-title":"J. Comp. Neurol."},{"issue":"42","key":"10.1016\/j.brainres.2019.02.026_b0600","doi-asserted-by":"crossref","first-page":"13906","DOI":"10.1523\/JNEUROSCI.2029-14.2014","article-title":"Role of glutamatergic projections from ventral tegmental area to lateral habenula in aversive conditioning","volume":"34","author":"Root","year":"2014","journal-title":"J. Neurosci."},{"key":"10.1016\/j.brainres.2019.02.026_b0610","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.pneurobio.2015.03.005","article-title":"The ventral pallidum: Subregion-specific functional anatomy and roles in motivated behaviors","volume":"130","author":"Root","year":"2015","journal-title":"Prog. Neurobiol."},{"issue":"4","key":"10.1016\/j.brainres.2019.02.026_b0615","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1002\/cne.10860","article-title":"Hypothalamic orexin (hypocretin) neurons express vesicular glutamate transporters VGLUT1 or VGLUT2","volume":"465","author":"Rosin","year":"2003","journal-title":"J. Comp. Neurol."},{"issue":"3","key":"10.1016\/j.brainres.2019.02.026_b0620","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/0014-2999(67)90084-2","article-title":"Inhibition of the uptake of tritiated catecholamines by antidepressant and related agents","volume":"2","author":"Ross","year":"1967","journal-title":"Eur. J. Pharmacol."},{"issue":"35","key":"10.1016\/j.brainres.2019.02.026_b0625","doi-asserted-by":"crossref","first-page":"13935","DOI":"10.1523\/JNEUROSCI.2680-13.2013","article-title":"Illuminating the opponent process: cocaine effects on habenulomesencephalic circuitry","volume":"33","author":"Rothwell","year":"2013","journal-title":"J. Neurosci."},{"key":"10.1016\/j.brainres.2019.02.026_b0630","doi-asserted-by":"crossref","first-page":"192","DOI":"10.3389\/fncir.2013.00192","article-title":"GABAergic neurons in the preoptic area send direct inhibitory projections to orexin neurons","volume":"7","author":"Saito","year":"2013","journal-title":"Front. Neural Circuits"},{"issue":"28","key":"10.1016\/j.brainres.2019.02.026_b0635","doi-asserted-by":"crossref","first-page":"6366","DOI":"10.1523\/JNEUROSCI.2835-17.2018","article-title":"Monoamines inhibit GABAergic neurons in ventrolateral preoptic area that make direct synaptic connections to hypothalamic arousal neurons","volume":"38","author":"Saito","year":"2018","journal-title":"J. Neurosci."},{"issue":"4","key":"10.1016\/j.brainres.2019.02.026_b0640","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1016\/S0092-8674(00)80949-6","article-title":"Orexins and orexin receptors: a family of hypothalamic neuropeptides and G protein-coupled receptors that regulate feeding behavior","volume":"92","author":"Sakurai","year":"1998","journal-title":"Cell"},{"key":"10.1016\/j.brainres.2019.02.026_b0650","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/j.neulet.2015.07.050","article-title":"Effects of activation and blockade of orexin A receptors in the medial preoptic area on food intake in male rats","volume":"604","author":"Sarihi","year":"2015","journal-title":"Neurosci. Lett."},{"issue":"4","key":"10.1016\/j.brainres.2019.02.026_b0655","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1016\/0091-3057(83)90283-6","article-title":"Morphine withdrawal produces differential effects on the rate of lever-pressing for brain self-stimulation in the hypothalamus and midbrain in rats","volume":"18","author":"Schaefer","year":"1983","journal-title":"Pharmacol. Biochem. Behav."},{"key":"10.1016\/j.brainres.2019.02.026_b0660","article-title":"Knockdown of hypocretin attenuates extended access of cocaine self-administration in rats","volume":"1","author":"Schmeichel","year":"2018","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.brainres.2019.02.026_b0670","doi-asserted-by":"crossref","unstructured":"Simmons, S.J., Barker, D.J., West, M.O., 2018a. Ultrasonic vocalizations capture opposing affective states during drug self-administration: revisiting the opponent-process model of addiction. In: Handbook of Ultrasonic Vocalization, Vol. 25, first ed.","DOI":"10.1016\/B978-0-12-809600-0.00037-8"},{"issue":"1","key":"10.1016\/j.brainres.2019.02.026_b0675","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1111\/adb.12479","article-title":"Comparing rewarding and reinforcing properties between \u2018bath salt\u20193, 4-methylenedioxypyrovalerone (MDPV) and cocaine using ultrasonic vocalizations in rats","volume":"23","author":"Simmons","year":"2018","journal-title":"Addict. Biol."},{"issue":"21","key":"10.1016\/j.brainres.2019.02.026_b0680","doi-asserted-by":"crossref","first-page":"3207","DOI":"10.1007\/s00213-017-4709-3","article-title":"Role of hypocretin\/orexin receptor blockade on drug-taking and ultrasonic vocalizations (USVs) associated with low-effort self-administration of cathinone-derived 3, 4-methylenedioxypyrovalerone (MDPV) in rats","volume":"234","author":"Simmons","year":"2017","journal-title":"Psychopharmacology"},{"key":"10.1016\/j.brainres.2019.02.026_b0685","first-page":"82","article-title":"Cloning, expression and characterisation of the orexin receptors","volume":"89","author":"Smart","year":"2000","journal-title":"Regul. Peptides"},{"issue":"38","key":"10.1016\/j.brainres.2019.02.026_b0690","doi-asserted-by":"crossref","first-page":"8637","DOI":"10.1523\/JNEUROSCI.1902-05.2005","article-title":"The ventral pallidum and hedonic reward: neurochemical maps of sucrose \u201cliking\u201d and food intake","volume":"25","author":"Smith","year":"2005","journal-title":"J. Neurosci."},{"issue":"3","key":"10.1016\/j.brainres.2019.02.026_b0695","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1111\/j.1460-9568.2009.06844.x","article-title":"Orexin\/hypocretin signaling at the orexin 1 receptor regulates cue-elicited cocaine-seeking","volume":"30","author":"Smith","year":"2009","journal-title":"Eur. J. Neurosci."},{"issue":"1","key":"10.1016\/j.brainres.2019.02.026_b0700","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/j.neuropharm.2009.06.042","article-title":"Orexin\/hypocretin is necessary for context-driven cocaine-seeking","volume":"58","author":"Smith","year":"2010","journal-title":"Neuropharmacology"},{"issue":"1\u20132","key":"10.1016\/j.brainres.2019.02.026_b9055","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/0006-8993(82)90685-0","article-title":"Dopaminergic substrates of amphetamine-induced place preference conditioning","volume":"253","author":"Spyraki","year":"1982","journal-title":"Brain Res."},{"issue":"1\u20132","key":"10.1016\/j.brainres.2019.02.026_b9060","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/0006-8993(82)90686-2","article-title":"Cocaine-induced place preference conditioning: lack of effects of neuroleptics and 6-hydroxydopamine lesions","volume":"253","author":"Spyraki","year":"1982","journal-title":"Brain Res."},{"issue":"8","key":"10.1016\/j.brainres.2019.02.026_b0705","doi-asserted-by":"crossref","first-page":"1105","DOI":"10.1038\/nn.3145","article-title":"Activation of lateral habenula inputs to the ventral midbrain promotes behavioral avoidance","volume":"15","author":"Stamatakis","year":"2012","journal-title":"Nat. Neurosci."},{"issue":"4","key":"10.1016\/j.brainres.2019.02.026_b0710","doi-asserted-by":"crossref","first-page":"1039","DOI":"10.1016\/j.neuron.2013.08.023","article-title":"A unique population of ventral tegmental area neurons inhibits the lateral habenula to promote reward","volume":"80","author":"Stamatakis","year":"2013","journal-title":"Neuron"},{"issue":"2","key":"10.1016\/j.brainres.2019.02.026_b0715","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1523\/JNEUROSCI.1202-15.2016","article-title":"Lateral hypothalamic area glutamatergic neurons and their projections to the lateral habenula regulate feeding and reward","volume":"36","author":"Stamatakis","year":"2016","journal-title":"J. Neurosci."},{"issue":"34","key":"10.1016\/j.brainres.2019.02.026_b0720","doi-asserted-by":"crossref","first-page":"13654","DOI":"10.1523\/JNEUROSCI.1570-13.2013","article-title":"Optogenetic evidence that pallidal projections, not nigral projections, from the nucleus accumbens core are necessary for reinstating cocaine seeking","volume":"33","author":"Stefanik","year":"2013","journal-title":"J. Neurosci."},{"key":"10.1016\/j.brainres.2019.02.026_b0725","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1016\/j.neuropharm.2018.02.010","article-title":"Hypocretin\/orexin deficiency decreases cocaine abuse liability","volume":"133","author":"Steiner","year":"2018","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.brainres.2019.02.026_b0730","first-page":"1","article-title":"Lateral preoptic and ventral pallidal roles in locomotion and other movements","author":"Subramanian","year":"2018","journal-title":"Brain Struct. Funct."},{"issue":"6","key":"10.1016\/j.brainres.2019.02.026_b9070","doi-asserted-by":"crossref","first-page":"935","DOI":"10.1002\/cne.24381","article-title":"Brain maps 4.0\u2014Structure of the rat brain: An open access atlas with global nervous system nomenclature ontology and flatmaps","volume":"526","author":"Swanson","year":"2018","journal-title":"J. Comp. Neurol."},{"issue":"2","key":"10.1016\/j.brainres.2019.02.026_b0735","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1007\/BF00413045","article-title":"Morphine self-administration, food-reinforced, and avoidance behaviors in rhesus monkeys","volume":"5","author":"Thompson","year":"1964","journal-title":"Psychopharmacology"},{"issue":"2","key":"10.1016\/j.brainres.2019.02.026_b0740","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/0306-4530(86)90052-1","article-title":"Inhibition of shock-elicited ultrasonic vocalization by opioid peptides in the rat: a psychotropic effect","volume":"11","author":"Tonoue","year":"1986","journal-title":"Psychoneuroendocrinology"},{"key":"10.1016\/j.brainres.2019.02.026_b0745","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopsych.2018.01.003","article-title":"Glutamatergic ventral pallidal neurons modulate activity of the habenula-tegmental circuitry and constrain reward seeking","author":"Tooley","year":"2018","journal-title":"Biol. Psychiatry"},{"issue":"1\u20132","key":"10.1016\/j.brainres.2019.02.026_b0750","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/S0014-5793(98)01266-6","article-title":"Distribution of orexin receptor mRNA in the rat brain","volume":"438","author":"Trivedi","year":"1998","journal-title":"FEBS Lett."},{"issue":"19","key":"10.1016\/j.brainres.2019.02.026_b0755","doi-asserted-by":"crossref","first-page":"7962","DOI":"10.1523\/JNEUROSCI.18-19-07962.1998","article-title":"Presynaptic and postsynaptic actions and modulation of neuroendocrine neurons by a new hypothalamic peptide, hypocretin\/orexin","volume":"18","author":"Van Den Pol","year":"1998","journal-title":"J. Neurosci."},{"issue":"10","key":"10.1016\/j.brainres.2019.02.026_b0760","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1016\/j.biopsych.2009.01.018","article-title":"Reinstatement of cocaine seeking by hypocretin (orexin) in the ventral tegmental area: independence from the local corticotropin-releasing factor network","volume":"65","author":"Wang","year":"2009","journal-title":"Biol. Psychiatry"},{"issue":"5","key":"10.1016\/j.brainres.2019.02.026_b0765","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1017\/S1461145713001570","article-title":"Optogenetic activation of GABAergic neurons in the nucleus accumbens decreases the activity of the ventral pallidum and the expression of cocaine-context-associated memory","volume":"17","author":"Wang","year":"2014","journal-title":"Int. J. Neuropsychopharmacol."},{"issue":"3537","key":"10.1016\/j.brainres.2019.02.026_b0770","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1126\/science.138.3537.143","article-title":"Experimental morphine addiction: method for automatic intravenous injections in unrestrained rats","volume":"138","author":"Weeks","year":"1962","journal-title":"Science"},{"issue":"7","key":"10.1016\/j.brainres.2019.02.026_b0775","doi-asserted-by":"crossref","first-page":"1069","DOI":"10.1002\/cmdc.200900069","article-title":"Discovery of a Potent, CNS-Penetrant Orexin Receptor Antagonist Based on an N, N-Disubstituted-1, 4-diazepane Scaffold that Promotes Sleep in Rats","volume":"4","author":"Whitman","year":"2009","journal-title":"ChemMedChem"},{"issue":"2","key":"10.1016\/j.brainres.2019.02.026_b0780","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1177\/0748730410395471","article-title":"Dynamic interactions between orexin and dynorphin may delay onset of functional orexin effects: a modeling study","volume":"26","author":"Williams","year":"2011","journal-title":"J. Biol. Rhythms"},{"issue":"1","key":"10.1016\/j.brainres.2019.02.026_b0785","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1523\/JNEUROSCI.13-01-00001.1993","article-title":"Activation of single neurons in the rat nucleus accumbens during self-stimulation of the ventral tegmental area","volume":"13","author":"Wolske","year":"1993","journal-title":"J. Neurosci."},{"key":"10.1016\/j.brainres.2019.02.026_b0790","article-title":"Ventral pallidal modulation of aversion processing","author":"Wulff","year":"2018","journal-title":"Brain Res."},{"issue":"5","key":"10.1016\/j.brainres.2019.02.026_b0795","doi-asserted-by":"crossref","first-page":"797","DOI":"10.33549\/physiolres.931574","article-title":"Orexin affects dorsal root ganglion neurons: a mechanism for regulating the spinal nociceptive processing","volume":"57","author":"Yan","year":"2008","journal-title":"Physiol. Res."},{"issue":"15","key":"10.1016\/j.brainres.2019.02.026_b0800","doi-asserted-by":"crossref","first-page":"1817","DOI":"10.1007\/s40265-014-0294-5","article-title":"Suvorexant: first global approval","volume":"74","author":"Yang","year":"2014","journal-title":"Drugs"},{"issue":"16","key":"10.1016\/j.brainres.2019.02.026_b0805","doi-asserted-by":"crossref","first-page":"2426","DOI":"10.1002\/cne.23797","article-title":"Sources of input to the rostromedial tegmental nucleus, ventral tegmental area, and lateral habenula compared: a study in rat","volume":"523","author":"Yetnikoff","year":"2015","journal-title":"J. Comp. Neurol."},{"issue":"2","key":"10.1016\/j.brainres.2019.02.026_b0815","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1016\/0006-8993(93)91387-8","article-title":"Voltammetry of extracellular dopamine in rat striatum during ICSS-like electrical stimulation of the medial forebrain bundle","volume":"600","author":"Young","year":"1993","journal-title":"Brain Res."},{"issue":"1","key":"10.1016\/j.brainres.2019.02.026_b0820","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1038\/s41398-018-0099-5","article-title":"A GABAergic cell type in the lateral habenula links hypothalamic homeostatic and midbrain motivation circuits with sex steroid signaling","volume":"8","author":"Zhang","year":"2018","journal-title":"Transl. Psychiatry"},{"issue":"13","key":"10.1016\/j.brainres.2019.02.026_b0825","doi-asserted-by":"crossref","first-page":"2741","DOI":"10.1038\/npp.2011.165","article-title":"Brain-cocaine concentrations determine the dose self-administered by rats on a novel behaviorally dependent dosing schedule","volume":"36","author":"Zimmer","year":"2011","journal-title":"Neuropsychopharmacology"},{"issue":"8","key":"10.1016\/j.brainres.2019.02.026_b0830","doi-asserted-by":"crossref","first-page":"1901","DOI":"10.1038\/npp.2012.37","article-title":"The motivation to self-administer is increased after a history of spiking brain levels of cocaine","volume":"37","author":"Zimmer","year":"2012","journal-title":"Neuropsychopharmacology"}],"container-title":["Brain Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006899319301106?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006899319301106?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,13]],"date-time":"2025-09-13T18:09:11Z","timestamp":1757786951000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006899319301106"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,3]]},"references-count":173,"alternative-id":["S0006899319301106"],"URL":"https:\/\/doi.org\/10.1016\/j.brainres.2019.02.026","relation":{},"ISSN":["0006-8993"],"issn-type":[{"value":"0006-8993","type":"print"}],"subject":[],"published":{"date-parts":[[2020,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Cocaine abuse and midbrain circuits: Functional anatomy of hypocretin\/orexin transmission and therapeutic prospect","name":"articletitle","label":"Article Title"},{"value":"Brain Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.brainres.2019.02.026","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"146164"}}