{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T17:58:41Z","timestamp":1787507921191,"version":"build-2736575974"},"reference-count":52,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,7,1]],"date-time":"2019-07-01T00:00:00Z","timestamp":1561939200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,7,1]],"date-time":"2019-07-01T00:00:00Z","timestamp":1561939200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundations of China","doi-asserted-by":"crossref","award":["81620108008"],"award-info":[{"award-number":["81620108008"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Hainan","award":["ZDYF2018153"],"award-info":[{"award-number":["ZDYF2018153"]}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Brain Research"],"published-print":{"date-parts":[[2019,7]]},"DOI":"10.1016\/j.brainres.2019.03.031","type":"journal-article","created":{"date-parts":[[2019,3,27]],"date-time":"2019-03-27T18:28:05Z","timestamp":1553711285000},"page":"224-234","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":9,"special_numbering":"C","title":["Serotoninergic projection from dorsal raphe nucleus to insular cortex is involved in acute itch sensation processing in mice"],"prefix":"10.1016","volume":"1715","author":[{"given":"Yan-Bing","family":"Chen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Bai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia-Ni","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yun-Qing","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.brainres.2019.03.031_b0005","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1196\/annals.1296.005","article-title":"Anatomic and functional topography of the dorsal raphe nucleus","volume":"1018","author":"Abrams","year":"2004","journal-title":"Ann. N.Y. Acad. Sci."},{"key":"10.1016\/j.brainres.2019.03.031_b0010","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/j.neuroscience.2012.01.027","article-title":"Disruptions in serotonergic regulation of cortical glutamate release in primate insular cortex in response to chronic ethanol and nursery rearing","volume":"207","author":"Alexander","year":"2012","journal-title":"Neuroscience"},{"key":"10.1016\/j.brainres.2019.03.031_b0015","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/cne.903110102","article-title":"Organization of visceral and limbic connections in the insular cortex of the rat","volume":"311","author":"Allen","year":"1991","journal-title":"J. Comp. Neurol."},{"key":"10.1016\/j.brainres.2019.03.031_b0020","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1002\/cne.903010202","article-title":"Cytoarchitecture of the human dorsal raphe nucleus","volume":"301","author":"Baker","year":"1990","journal-title":"J. Comp. Neurol."},{"key":"10.1016\/j.brainres.2019.03.031_b0025","doi-asserted-by":"crossref","first-page":"1083","DOI":"10.1016\/S0028-3908(99)00010-6","article-title":"A review of central 5-HT receptors and their function","volume":"38","author":"Barnes","year":"1999","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.brainres.2019.03.031_b0030","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1016\/j.cell.2009.09.028","article-title":"Cellular and molecular mechanisms of pain","volume":"139","author":"Basbaum","year":"2009","journal-title":"Cell"},{"key":"10.1016\/j.brainres.2019.03.031_b0035","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1192\/bjp.171.5.444","article-title":"Serotonin 5-HT2 receptor imaging in major depression: focal changes in orbito-insular cortex","volume":"171","author":"Biver","year":"1997","journal-title":"Br. J. Psychiatry"},{"key":"10.1016\/j.brainres.2019.03.031_b0040","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/j.bbr.2017.07.044","article-title":"Modulation of the storage of social recognition memory by neurotransmitter systems in the insular cortex","volume":"334","author":"Cavalcante","year":"2017","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.brainres.2019.03.031_b0045","doi-asserted-by":"crossref","first-page":"25","DOI":"10.3389\/fnint.2013.00025","article-title":"Serotonin modulation of cortical neurons and networks","volume":"7","author":"Celada","year":"2013","journal-title":"Front. Integr. Neurosci."},{"issue":"Suppl 9A","key":"10.1016\/j.brainres.2019.03.031_b0050","doi-asserted-by":"crossref","first-page":"25S","DOI":"10.1016\/S0002-9343(02)01434-1","article-title":"Pruritic dermatoses: overview of etiology and therapy","volume":"113","author":"Charlesworth","year":"2002","journal-title":"Am. J. Med."},{"key":"10.1016\/j.brainres.2019.03.031_b0055","doi-asserted-by":"crossref","first-page":"471","DOI":"10.31887\/DCNS.2010.12.4\/ycharnay","article-title":"Brain serotonergic circuitries","volume":"12","author":"Charnay","year":"2010","journal-title":"Dialogues Clin. Neurosci."},{"key":"10.1016\/j.brainres.2019.03.031_b0060","first-page":"299","article-title":"Fos, nociception and the dorsal horn","volume":"77","author":"Coggeshall","year":"2005","journal-title":"Prog. Neurobiol."},{"key":"10.1016\/j.brainres.2019.03.031_b0065","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1016\/S0959-4388(03)00090-4","article-title":"Interoception: the sense of the physiological condition of the body","volume":"13","author":"Craig","year":"2003","journal-title":"Curr. Opin. Neurobiol."},{"key":"10.1016\/j.brainres.2019.03.031_b0070","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1038\/nrn2555","article-title":"How do you feel\u2013now? The anterior insula and human awareness","volume":"10","author":"Craig","year":"2009","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.brainres.2019.03.031_b0075","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1007\/s00429-010-0248-y","article-title":"The sentient self","volume":"214","author":"Craig","year":"2010","journal-title":"Brain Struct. Funct."},{"key":"10.1016\/j.brainres.2019.03.031_b0080","doi-asserted-by":"crossref","first-page":"10007","DOI":"10.1523\/JNEUROSCI.2862-07.2007","article-title":"The itch-producing agents histamine and cowhage activate separate populations of primate spinothalamic tract neurons","volume":"27","author":"Davidson","year":"2007","journal-title":"J. Neurosci."},{"key":"10.1016\/j.brainres.2019.03.031_b0085","doi-asserted-by":"crossref","first-page":"1711","DOI":"10.1152\/jn.00206.2012","article-title":"Pruriceptive spinothalamic tract neurons: physiological properties and projection targets in the primate","volume":"108","author":"Davidson","year":"2012","journal-title":"J. Neurophysiol."},{"key":"10.1016\/j.brainres.2019.03.031_b0090","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1016\/j.neuron.2018.03.023","article-title":"Peripheral and central mechanisms of itch","volume":"98","author":"Dong","year":"2018","journal-title":"Neuron"},{"key":"10.1016\/j.brainres.2019.03.031_b0095","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1016\/S0361-9230(79)80012-X","article-title":"Neural inputs to the prefrontal agranular insular cortex in the rat: horseradish peroxidase study","volume":"4","author":"Gerfen","year":"1979","journal-title":"Brain Res. Bull."},{"key":"10.1016\/j.brainres.2019.03.031_b0100","doi-asserted-by":"crossref","first-page":"835","DOI":"10.1093\/brain\/awh098","article-title":"Pain catastrophizing and neural responses to pain among persons with fibromyalgia","volume":"127","author":"Gracely","year":"2004","journal-title":"Brain"},{"key":"10.1016\/j.brainres.2019.03.031_b0105","doi-asserted-by":"crossref","first-page":"2347","DOI":"10.1152\/jn.00475.2007","article-title":"Itch induced by a novel method leads to limbic deactivations a functional MRI study","volume":"98","author":"Herde","year":"2007","journal-title":"J. Neurophysiol."},{"key":"10.1016\/j.brainres.2019.03.031_b0110","doi-asserted-by":"crossref","first-page":"19816","DOI":"10.1073\/pnas.1216160109","article-title":"Neural basis of contagious itch and why some people are more prone to it","volume":"109","author":"Holle","year":"2012","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.brainres.2019.03.031_b0115","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1038\/s41593-018-0119-z","article-title":"Circuit dissection of the role of somatostatin in itch and pain","volume":"21","author":"Huang","year":"2018","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.brainres.2019.03.031_b0120","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1186\/1756-6606-6-59","article-title":"Analysis of sleep disorders under pain using an optogenetic tool: possible involvement of the activation of dorsal raphe nucleus-serotonergic neurons","volume":"6","author":"Ito","year":"2013","journal-title":"Mol. Brain"},{"key":"10.1016\/j.brainres.2019.03.031_b0125","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1002\/cne.10978","article-title":"Rostral agranular insular cortex and pain areas of the central nervous system: a tract-tracing study in the rat","volume":"468","author":"Jasmin","year":"2004","journal-title":"J. Comp. Neurol."},{"key":"10.1016\/j.brainres.2019.03.031_b0130","doi-asserted-by":"crossref","first-page":"547","DOI":"10.4196\/kjpp.2018.22.5.547","article-title":"Antipruritic effect of curcumin on histamine-induced itching in mice","volume":"22","author":"Lee","year":"2018","journal-title":"Korean J. Physiol. Pharmacol."},{"key":"10.1016\/j.brainres.2019.03.031_b0135","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1152\/jn.00070.2006","article-title":"Itch and motivation to scratch: an investigation of the central and peripheral correlates of allergen- and histamine-induced itch in humans","volume":"97","author":"Leknes","year":"2007","journal-title":"J. Neurophysiol."},{"key":"10.1016\/j.brainres.2019.03.031_b0140","first-page":"5","article-title":"Nausea-induced 5-HT release in the interoceptive insular cortex and regulation by monoacylglycerol lipase (MAGL) inhibition and cannabidiol","author":"Limebeer","year":"2018","journal-title":"eNeuro"},{"key":"10.1016\/j.brainres.2019.03.031_b0145","doi-asserted-by":"crossref","first-page":"1360","DOI":"10.1016\/j.neuron.2014.02.010","article-title":"Dorsal raphe neurons signal reward through 5-HT and glutamate","volume":"81","author":"Liu","year":"2014","journal-title":"Neuron"},{"key":"10.1016\/j.brainres.2019.03.031_b0150","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1196\/annals.1410.004","article-title":"Serotonergic systems, anxiety, and affective disorder: focus on the dorsomedial part of the dorsal raphe nucleus","volume":"1148","author":"Lowry","year":"2008","journal-title":"Ann. N.Y. Acad. Sci."},{"key":"10.1016\/j.brainres.2019.03.031_b0155","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1007\/s12264-016-0016-y","article-title":"Insular cortex is critical for the perception, modulation, and chronification of pain","volume":"32","author":"Lu","year":"2016","journal-title":"Neurosci. Bull."},{"key":"10.1016\/j.brainres.2019.03.031_b0160","doi-asserted-by":"crossref","first-page":"561","DOI":"10.3758\/s13415-016-0415-6","article-title":"Dorsal raphe nucleus and harm avoidance: a resting-state investigation","volume":"16","author":"Meylakh","year":"2016","journal-title":"Cogn. Affect Behav. Neurosci."},{"key":"10.1016\/j.brainres.2019.03.031_b0165","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/S0079-6123(08)00912-6","article-title":"The dorsal raphe nucleus and serotonin: implications for neuroplasticity linked to major depression and Alzheimer's disease","volume":"172","author":"Michelsen","year":"2008","journal-title":"Prog. Brain Res."},{"key":"10.1016\/j.brainres.2019.03.031_b0170","doi-asserted-by":"crossref","first-page":"706","DOI":"10.1016\/j.neuroimage.2007.04.003","article-title":"Neural correlates of perceptual difference between itching and pain: a human fMRI study","volume":"36","author":"Mochizuki","year":"2007","journal-title":"Neuroimage"},{"key":"10.1016\/j.brainres.2019.03.031_b0175","doi-asserted-by":"crossref","first-page":"2657","DOI":"10.1152\/jn.00460.2009","article-title":"Time course of activity in itch-related brain regions: a combined MEG-fMRI study","volume":"102","author":"Mochizuki","year":"2009","journal-title":"J. Neurophysiol."},{"key":"10.1016\/j.brainres.2019.03.031_b0180","doi-asserted-by":"crossref","first-page":"1989","DOI":"10.1016\/j.pain.2013.06.007","article-title":"Cortico-subcortical activation patterns for itch and pain imagery","volume":"154","author":"Mochizuki","year":"2013","journal-title":"Pain"},{"key":"10.1016\/j.brainres.2019.03.031_b0185","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1152\/jn.00374.2013","article-title":"The cerebral representation of scratching-induced pleasantness","volume":"111","author":"Mochizuki","year":"2014","journal-title":"J. Neurophysiol."},{"key":"10.1016\/j.brainres.2019.03.031_b0190","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1016\/0006-8993(79)90029-5","article-title":"A map of serotoninergic structures involved in stimulation producing analgesia in unrestrained freely moving cats","volume":"164","author":"Oliveras","year":"1979","journal-title":"Brain Res."},{"key":"10.1016\/j.brainres.2019.03.031_b0195","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/j.ejphar.2004.03.063","article-title":"Metabotropic glutamate receptor 5 and dorsal raphe serotonin release in inflammatory pain in rat","volume":"492","author":"Palazzo","year":"2004","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.brainres.2019.03.031_b0200","doi-asserted-by":"crossref","first-page":"3611","DOI":"10.1016\/j.neuroimage.2011.10.099","article-title":"A tale of two itches. Common features and notable differences in brain activation evoked by cowhage and histamine induced itch","volume":"59","author":"Papoiu","year":"2012","journal-title":"Neuroimage"},{"key":"10.1016\/j.brainres.2019.03.031_b0205","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0082389","article-title":"Brain's reward circuits mediate itch relief. a functional MRI study of active scratching","volume":"8","author":"Papoiu","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.brainres.2019.03.031_b0210","series-title":"The MouseBrain in Stereotaxic Coordinates","author":"Paxinos","year":"2001"},{"key":"10.1016\/j.brainres.2019.03.031_b0215","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1093\/cercor\/bhh104","article-title":"Modulation of the activity of pyramidal neurons in rat prefrontal cortex by raphe stimulation in vivo: involvement of serotonin and GABA","volume":"15","author":"Puig","year":"2005","journal-title":"Cereb. Cortex"},{"key":"10.1016\/j.brainres.2019.03.031_b0220","doi-asserted-by":"crossref","first-page":"1265","DOI":"10.1016\/0306-4522(82)91133-2","article-title":"Afferent connections of dorsal and ventral agranular insular cortex in the hamster Mesocricetus auratus","volume":"7","author":"Reep","year":"1982","journal-title":"Neuroscience"},{"key":"10.1016\/j.brainres.2019.03.031_b0225","doi-asserted-by":"crossref","first-page":"1370","DOI":"10.1172\/JCI90678","article-title":"Prostaglandin-mediated inhibition of serotonin signaling controls the affective component of inflammatory pain","volume":"127","author":"Singh","year":"2017","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.brainres.2019.03.031_b0230","doi-asserted-by":"crossref","first-page":"291","DOI":"10.2340\/00015555-0305","article-title":"Clinical classification of itch: a position paper of the International Forum for the Study of Itch","volume":"87","author":"Stander","year":"2007","journal-title":"Acta Derm. Venereol."},{"key":"10.1016\/j.brainres.2019.03.031_b0235","doi-asserted-by":"crossref","first-page":"1104","DOI":"10.1111\/nmo.12815","article-title":"Role of 5-HT1A receptor in insular cortex mediating stress - induced visceral sensory dysfunction","volume":"28","author":"Sun","year":"2016","journal-title":"Neurogastroenterol. Motil."},{"key":"10.1016\/j.brainres.2019.03.031_b0240","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1046\/j.1471-4159.2001.00054.x","article-title":"The neuronal MAP kinase cascade: a biochemical signal integration system subserving synaptic plasticity and memory","volume":"76","author":"Sweatt","year":"2001","journal-title":"J. Neurochem."},{"key":"10.1016\/j.brainres.2019.03.031_b0245","doi-asserted-by":"crossref","first-page":"493","DOI":"10.3389\/fncel.2015.00493","article-title":"Corticotrigeminal projections from the insular cortex to the trigeminal caudal subnucleus regulate orofacial pain after nerve injury via extracellular signal-regulated kinase activation in insular cortex neurons","volume":"9","author":"Wang","year":"2015","journal-title":"Front. Cell Neurosci."},{"key":"10.1016\/j.brainres.2019.03.031_b0250","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1016\/0361-9230(94)90143-0","article-title":"The dorsal raphe: an important nucleus in pain modulation","volume":"34","author":"Wang","year":"1994","journal-title":"Brain Res. Bull."},{"key":"10.1016\/j.brainres.2019.03.031_b0255","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1016\/j.jchemneu.2011.05.011","article-title":"Collateralized dorsal raphe nucleus projections: a mechanism for the integration of diverse functions during stress","volume":"41","author":"Waselus","year":"2011","journal-title":"J. Chem. Neuroanat."},{"key":"10.1016\/j.brainres.2019.03.031_b0260","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1016\/j.neuron.2014.10.003","article-title":"Descending control of itch transmission by the serotonergic system via 5-HT1A-facilitated GRP-GRPR signaling","volume":"84","author":"Zhao","year":"2014","journal-title":"Neuron"}],"container-title":["Brain Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006899319301702?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006899319301702?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,13]],"date-time":"2025-09-13T18:03:22Z","timestamp":1757786602000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006899319301702"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,7]]},"references-count":52,"alternative-id":["S0006899319301702"],"URL":"https:\/\/doi.org\/10.1016\/j.brainres.2019.03.031","relation":{},"ISSN":["0006-8993"],"issn-type":[{"value":"0006-8993","type":"print"}],"subject":[],"published":{"date-parts":[[2019,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Serotoninergic projection from dorsal raphe nucleus to insular cortex is involved in acute itch sensation processing in mice","name":"articletitle","label":"Article Title"},{"value":"Brain Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.brainres.2019.03.031","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}