{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T14:06:21Z","timestamp":1792850781251,"version":"4.5.0"},"reference-count":47,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,9,1]],"date-time":"2019-09-01T00:00:00Z","timestamp":1567296000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,9,1]],"date-time":"2019-09-01T00:00:00Z","timestamp":1567296000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Brain Research"],"published-print":{"date-parts":[[2019,9]]},"DOI":"10.1016\/j.brainres.2019.05.028","type":"journal-article","created":{"date-parts":[[2019,5,22]],"date-time":"2019-05-22T13:48:41Z","timestamp":1558532921000},"page":"11-16","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":60,"special_numbering":"C","title":["Sex differences in mixed neuropathologies in community-dwelling older adults"],"prefix":"10.1016","volume":"1719","author":[{"given":"Lisa L.","family":"Barnes","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melissa","family":"Lamar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julie A.","family":"Schneider","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.brainres.2019.05.028_b0005","doi-asserted-by":"crossref","first-page":"934","DOI":"10.1016\/S1474-4422(16)30029-1","article-title":"Relation of cerebral vessel disease to Alzheimer\u2019s disease dementia and cognitive function in elderly people: a cross-sectional study","volume":"15","author":"Arvanitakis","year":"2016","journal-title":"Lancet Neurol."},{"key":"10.1016\/j.brainres.2019.05.028_b9005","doi-asserted-by":"crossref","first-page":"722","DOI":"10.1161\/STROKEAHA.110.595082","article-title":"Microinfarct pathology, dementia, and cognitive systems","volume":"27","author":"Arvanitakis","year":"2011","journal-title":"Stroke"},{"key":"10.1016\/j.brainres.2019.05.028_b0010","doi-asserted-by":"crossref","first-page":"736","DOI":"10.2174\/156720512801322627","article-title":"The minority aging research study: ongoing efforts to obtain brain donation in African Americans without dementia","volume":"9","author":"Barnes","year":"2012","journal-title":"Curr. Alzheimer Res."},{"issue":"6","key":"10.1016\/j.brainres.2019.05.028_b0015","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1001\/archpsyc.62.6.685","article-title":"Sex differences in the clinical manifestations of Alzheimer disease pathology","volume":"62","author":"Barnes","year":"2005","journal-title":"Arch. Gen. Psychiat."},{"key":"10.1016\/j.brainres.2019.05.028_b0020","doi-asserted-by":"crossref","first-page":"1777","DOI":"10.1212\/01.WNL.0000065892.67099.2A","article-title":"Gender, cognitive decline, and risk of AD in older persons","volume":"60","author":"Barnes","year":"2003","journal-title":"Neurology"},{"issue":"s1","key":"10.1016\/j.brainres.2019.05.028_b0025","doi-asserted-by":"crossref","first-page":"S161","DOI":"10.3233\/JAD-179939","article-title":"Religious orders study and rush memory and aging project","volume":"64","author":"Bennett","year":"2018","journal-title":"J. Alzheim. Dis."},{"key":"10.1016\/j.brainres.2019.05.028_b0030","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1159\/000096129","article-title":"Decision rules guiding the clinical diagnosis of Alzheimer's disease in two community-based cohort studies compared to standard practice in a clinic-based cohort study","volume":"27","author":"Bennett","year":"2006","journal-title":"Neuroepidemiology"},{"issue":"1","key":"10.1016\/j.brainres.2019.05.028_b0035","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1002\/ana.25123","article-title":"Person-specific contribution of neuropathologies to cognitive loss in old age","volume":"83","author":"Boyle","year":"2018","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.brainres.2019.05.028_b0040","doi-asserted-by":"crossref","first-page":"1930","DOI":"10.1212\/WNL.0000000000002175","article-title":"Cerebral, angiopathy and cognitive outcomes in community based older adults","volume":"85","author":"Boyle","year":"2015","journal-title":"Neurology"},{"key":"10.1016\/j.brainres.2019.05.028_b0045","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1007\/BF00308809","article-title":"Neuropathological stageing of Alzheimer-related changes","volume":"82","author":"Braak","year":"1991","journal-title":"Acta Neuropathol."},{"key":"10.1016\/j.brainres.2019.05.028_b0050","doi-asserted-by":"crossref","first-page":"3183","DOI":"10.1161\/STROKEAHA.111.623462","article-title":"Cerebrovascular disease pathology and parkinsonian signs in old age","volume":"42","author":"Buchman","year":"2011","journal-title":"Stroke"},{"key":"10.1016\/j.brainres.2019.05.028_b0055","doi-asserted-by":"crossref","first-page":"e1821","DOI":"10.1212\/WNL.0000000000007315","article-title":"Progressive parkinsonism in older adults is related to burden of mixed brain pathologies","volume":"92","author":"Buchman","year":"2019","journal-title":"Neurology"},{"key":"10.1016\/j.brainres.2019.05.028_b0060","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1196\/annals.1297.005","article-title":"The biphasic relationship between regional brain senile plaque and neurofibrillary tangle distributions: modification by age, sex, and APOE polymorphism","volume":"1019","author":"Corder","year":"2004","journal-title":"Ann. NY. Acad. Sci."},{"issue":"8","key":"10.1016\/j.brainres.2019.05.028_b0065","doi-asserted-by":"crossref","first-page":"748","DOI":"10.1093\/jnen\/nlw047","article-title":"Gender differences in alzheimer disease: brain atrophy, histopathology burden, and cognition","volume":"75","author":"Filon","year":"2016","journal-title":"J. Neuropathol. Exp. Neurol."},{"issue":"3","key":"10.1016\/j.brainres.2019.05.028_b0070","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1016\/j.yfrne.2014.02.002","article-title":"Sex differences in Parkinson's disease","volume":"35","author":"Gillies","year":"2014","journal-title":"Front. Neuroendocrinol."},{"issue":"1","key":"10.1016\/j.brainres.2019.05.028_b0075","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1136\/jech.35.1.45","article-title":"Sex differences in the incidence of cerebrovascular disease","volume":"35","author":"Haberman","year":"1981","journal-title":"J. Epidemiol. Commun. Health"},{"key":"10.1016\/j.brainres.2019.05.028_b0080","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1093\/aje\/153.2.132","article-title":"Is the risk of developing Alzheimer's disease greater for women than for men?","volume":"153","author":"Hebert","year":"2001","journal-title":"Am. J. Epidemiol."},{"issue":"19","key":"10.1016\/j.brainres.2019.05.028_b0085","doi-asserted-by":"crossref","first-page":"1778","DOI":"10.1212\/WNL.0b013e31828726f5","article-title":"Alzheimer disease in the United States (2010\u20132050) estimated using the 2010 census","volume":"80","author":"Hebert","year":"2013","journal-title":"Neurology"},{"issue":"11","key":"10.1016\/j.brainres.2019.05.028_b0090","doi-asserted-by":"crossref","first-page":"2983","DOI":"10.1093\/brain\/aww224","article-title":"TDP-43 stage, mixed pathologies, and clinical Alzheimer's-type dementia","volume":"139","author":"James","year":"2016","journal-title":"Brain"},{"issue":"4","key":"10.1016\/j.brainres.2019.05.028_b0095","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1007\/s00401-017-1717-7","article-title":"Impact of multiple pathologies on the threshold for clinically overt dementia","volume":"132","author":"Kapasi","year":"2017","journal-title":"Acta Neuropathol."},{"issue":"6","key":"10.1016\/j.brainres.2019.05.028_b0100","doi-asserted-by":"crossref","first-page":"873","DOI":"10.1007\/s00401-018-1908-x","article-title":"Sex and age interact to determine clinicopathologic differences in Alzheimer\u2019s disease","volume":"136","author":"Liesinger","year":"2018","journal-title":"Acta Neuropathol."},{"issue":"3 Suppl","key":"10.1016\/j.brainres.2019.05.028_b9000","first-page":"417","article-title":"Consensus guidelines for the clinical and pathologic diagnosis of dementia with Lewy bodies (DLB): report of the Consortium on DLB International Workshop","volume":"9","author":"McKeith","year":"2014","journal-title":"J. Alzheimers Dis."},{"issue":"1","key":"10.1016\/j.brainres.2019.05.028_b0105","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1212\/WNL.0000000000004058","article-title":"Diagnosis and management of dementia with Lewy bodies: Fourth consensus report of the DLB Consortium","volume":"89","author":"McKeith","year":"2017","journal-title":"Neurology"},{"key":"10.1016\/j.brainres.2019.05.028_b0110","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/j.jalz.2011.03.005","article-title":"The diagnosis of dementia due to Alzheimer\u2019s disease: recommendations from the National Institute on Aging-Alzheimer\u2019s Association workgroups on diagnostic guidelines for Alzheimer\u2019s disease","volume":"7","author":"McKhann","year":"2011","journal-title":"Alzheimers Dement."},{"issue":"6","key":"10.1016\/j.brainres.2019.05.028_b0115","doi-asserted-by":"crossref","first-page":"1276","DOI":"10.1016\/j.ahj.2005.02.037","article-title":"Women with a low Framingham risk score and a family history of premature coronary heart disease have a high prevalence of subclinical coronary atherosclerosis","volume":"150","author":"Michos","year":"2005","journal-title":"AHJ"},{"key":"10.1016\/j.brainres.2019.05.028_b0120","doi-asserted-by":"crossref","first-page":"1737","DOI":"10.1212\/WNL.0b013e318236f0cf","article-title":"Neuropathologic features associated with Alzheimer disease diagnosis: age matters","volume":"77","author":"Middleton","year":"2011","journal-title":"Neurology"},{"key":"10.1016\/j.brainres.2019.05.028_b0125","doi-asserted-by":"crossref","first-page":"37","DOI":"10.2147\/CLEP.S37929","article-title":"Clinical epidemiology of Alzheimer's disease: assessing sex and gender differences","volume":"6","author":"Mielke","year":"2014","journal-title":"Clin. Epidemiol."},{"issue":"3","key":"10.1016\/j.brainres.2019.05.028_b0130","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1093\/oxfordjournals.aje.a113897","article-title":"A descriptive study of neuritic plaques and neurofibrillary tangles in an autopsy population","volume":"120","author":"Miller","year":"1984","journal-title":"Am. J. Epidemiol."},{"key":"10.1016\/j.brainres.2019.05.028_b0135","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1212\/WNL.41.4.479","article-title":"The consortium to establish a registry for Alzheimer's Disease (CERAD). Part II. standardization of the neuropathologic assessment of Alzheimer's disease","volume":"41","author":"Mirra","year":"1991","journal-title":"Neurology"},{"issue":"1","key":"10.1016\/j.brainres.2019.05.028_b0140","doi-asserted-by":"crossref","DOI":"10.1186\/s13195-018-0417-4","article-title":"Sex ratio in dementia with Lewy bodies balanced between Alzheimer\u2019s disease and Parkinson\u2019s disease dementia: a cross-sectional study","volume":"10","author":"Mouton","year":"2018","journal-title":"Alz. Res. Therapy"},{"issue":"7","key":"10.1016\/j.brainres.2019.05.028_b0145","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1212\/WNL.0000000000003610","article-title":"TDP-43 pathology and memory impairment in elders without pathologic diagnosis of AD or FTLD","volume":"88","author":"Nag","year":"2017","journal-title":"Neurology"},{"key":"10.1016\/j.brainres.2019.05.028_b0150","doi-asserted-by":"crossref","first-page":"942","DOI":"10.1002\/ana.24388","article-title":"Hippocampal sclerosis and TDP-43 pathology in aging and Alzheimer disease","volume":"77","author":"Nag","year":"2015","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.brainres.2019.05.028_b0155","first-page":"S1","article-title":"Reagan Institute Working Group on Diagnostic Criteria for the Neuropathological Assessmet of Alzheimer's Disease. Consensus recommendations for the postmortem diagnosis of Alzheimer's disease","volume":"18","year":"1997","journal-title":"Neurobiol Aging"},{"key":"10.1016\/j.brainres.2019.05.028_b0160","doi-asserted-by":"crossref","DOI":"10.1016\/j.jalz.2018.04.008","article-title":"Understanding the impact of sex and gender in Alzheimer\u2019s disease: a call to action","author":"Nebel","year":"2018","journal-title":"Alzheim. Demen."},{"issue":"11","key":"10.1016\/j.brainres.2019.05.028_b0165","doi-asserted-by":"crossref","first-page":"1875","DOI":"10.1007\/s00415-010-5630-4","article-title":"Association between male gender and cortical Lewy body pathology in large autopsy series","volume":"257","author":"Nelson","year":"2010","journal-title":"J. Neurol."},{"key":"10.1016\/j.brainres.2019.05.028_b0170","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1007\/s00401-008-0477-9","article-title":"Phosphorylation of S409\/410 of TDP-43 is a consistent feature in all sporadic and familial forms ofTDP-43 proteinopathies","volume":"117","author":"Neumann","year":"2009","journal-title":"Acta Neuropathol."},{"issue":"6","key":"10.1016\/j.brainres.2019.05.028_b0175","doi-asserted-by":"crossref","first-page":"887","DOI":"10.1007\/s00401-018-1920-1","article-title":"Sex differences in Alzheimer\u2019s disease and common neuropathologies of aging","volume":"136","author":"Oveisgharan","year":"2018","journal-title":"Acta Neuropathol."},{"issue":"10","key":"10.1016\/j.brainres.2019.05.028_b0180","first-page":"1232","article-title":"Risk stratification for cardiovascular disease in women in the primary care setting","volume":"28","author":"Roy","year":"2015","journal-title":"JASE"},{"issue":"2","key":"10.1016\/j.brainres.2019.05.028_b0185","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/S0197-4580(00)00236-0","article-title":"The prevalence of the neuropathological lesions of Alzheimer's disease is independent of race and gender","volume":"22","author":"Sandberg","year":"2001","journal-title":"Neurobiol. Aging"},{"issue":"1","key":"10.1016\/j.brainres.2019.05.028_b0190","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1186\/2042-6410-3-7","article-title":"Sex differences in primary hypertension","volume":"3","author":"Sandberg","year":"2012","journal-title":"Biol. Sex Differ."},{"issue":"11","key":"10.1016\/j.brainres.2019.05.028_b0195","doi-asserted-by":"crossref","first-page":"1396","DOI":"10.1001\/jamaneurol.2013.3579","article-title":"Incidence of dementia with Lewy bodies and Parkinson disease dementia","volume":"70","author":"Savica","year":"2013","journal-title":"JAMA Neurol."},{"issue":"3","key":"10.1016\/j.brainres.2019.05.028_b0200","doi-asserted-by":"crossref","first-page":"691","DOI":"10.3233\/JAD-2009-1227","article-title":"The neuropathology of older persons with and without dementia from community versus clinic cohorts","volume":"18","author":"Schneider","year":"2009","journal-title":"J. Alzheim. Dis."},{"key":"10.1016\/j.brainres.2019.05.028_b0205","doi-asserted-by":"crossref","first-page":"2197","DOI":"10.1212\/01.wnl.0000271090.28148.24","article-title":"Mixed brain pathologies account for most dementia cases in community-dwelling older persons","volume":"69","author":"Schneider","year":"2007","journal-title":"Neurology"},{"issue":"7","key":"10.1016\/j.brainres.2019.05.028_b0210","doi-asserted-by":"crossref","first-page":"1148","DOI":"10.1212\/01.WNL.0000118211.78503.F5","article-title":"Cerebral infarctions and the likelihood of dementia from Alzheimer disease pathology","volume":"62","author":"Schneider","year":"2004","journal-title":"Neurology"},{"issue":"2","key":"10.1016\/j.brainres.2019.05.028_b0215","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1007\/s00401-016-1580-y","article-title":"Impact of sex and APOE4 on cerebral amyloid angiopathy in Alzheimer's disease","volume":"132","author":"Shinohara","year":"2016","journal-title":"Acta Neuropathol."},{"issue":"12","key":"10.1016\/j.brainres.2019.05.028_b0220","doi-asserted-by":"crossref","first-page":"1729","DOI":"10.1002\/mds.27200","article-title":"Sleep fragmentation and Parkinson\u2019s disease pathology in older adults without Parkinson\u2019s disease","volume":"32","author":"Sohail","year":"2017","journal-title":"Mov. Disord."},{"key":"10.1016\/j.brainres.2019.05.028_b0225","doi-asserted-by":"crossref","first-page":"1418","DOI":"10.1001\/jamaneurol.2013.3961","article-title":"TDP-43 pathology, cognitive decline, and dementia in old age","volume":"70","author":"Wilson","year":"2013","journal-title":"JAMA Neurol."}],"container-title":["Brain Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006899319302835?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006899319302835?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,13]],"date-time":"2025-09-13T18:01:14Z","timestamp":1757786474000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006899319302835"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,9]]},"references-count":47,"alternative-id":["S0006899319302835"],"URL":"https:\/\/doi.org\/10.1016\/j.brainres.2019.05.028","relation":{},"ISSN":["0006-8993"],"issn-type":[{"value":"0006-8993","type":"print"}],"subject":[],"published":{"date-parts":[[2019,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Sex differences in mixed neuropathologies in community-dwelling older adults","name":"articletitle","label":"Article Title"},{"value":"Brain Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.brainres.2019.05.028","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}