{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,29]],"date-time":"2026-06-29T16:24:10Z","timestamp":1782750250094,"version":"3.54.5"},"reference-count":33,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,9,1]],"date-time":"2019-09-01T00:00:00Z","timestamp":1567296000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,9,1]],"date-time":"2019-09-01T00:00:00Z","timestamp":1567296000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100004663","name":"Ministry of Science and Technology, Taiwan","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004663","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004737","name":"National Health Research Institutes","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004737","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Brain Research"],"published-print":{"date-parts":[[2019,9]]},"DOI":"10.1016\/j.brainres.2019.05.040","type":"journal-article","created":{"date-parts":[[2019,5,30]],"date-time":"2019-05-30T02:04:01Z","timestamp":1559181841000},"page":"124-132","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":10,"special_numbering":"C","title":["NanoCsA improves the survival of human iPSC transplant in hemiparkinsonian rats"],"prefix":"10.1016","volume":"1719","author":[{"given":"Seong-Jin","family":"Yu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu-Chao","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chia-Yu","family":"Chang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Hsieh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuchun","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chung-Shi","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shinn-Zong","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yun","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.brainres.2019.05.040_b0005","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1002\/cne.22039","article-title":"Mesencephalic astrocyte-derived neurotrophic factor (MANF) reduces ischemic brain injury and promotes behavioral recovery in rats","volume":"515","author":"Airavaara","year":"2009","journal-title":"J. Comp. Neurol."},{"key":"10.1016\/j.brainres.2019.05.040_b0010","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/S0140-6736(85)92053-7","article-title":"Severe central-nervous-system toxicity associated with cyclosporin","volume":"1","author":"Berden","year":"1985","journal-title":"Lancet"},{"key":"10.1016\/j.brainres.2019.05.040_b0015","doi-asserted-by":"crossref","first-page":"117","DOI":"10.3109\/00313028409059087","article-title":"Tissue distribution and toxicity of cyclosporin A in the mouse","volume":"16","author":"Boland","year":"1984","journal-title":"Pathology"},{"key":"10.1016\/j.brainres.2019.05.040_b0020","doi-asserted-by":"crossref","first-page":"636","DOI":"10.1006\/nbdi.2001.0410","article-title":"Involvement of GDNF in neuronal protection against 6-OHDA -induced Parkinsonism following intracerebral transplantation of fetal kidney tissues in adult rats","volume":"8","author":"Borlongan","year":"2001","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.brainres.2019.05.040_b0025","doi-asserted-by":"crossref","first-page":"2385","DOI":"10.1161\/01.STR.0000141680.49960.d7","article-title":"Central nervous system entry of peripherally injected umbilical cord blood cells is not required for neuroprotection in stroke","volume":"35","author":"Borlongan","year":"2004","journal-title":"Stroke"},{"key":"10.1016\/j.brainres.2019.05.040_b0030","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1016\/j.ijpharm.2006.11.061","article-title":"Haloperidol-loaded PLGA nanoparticles: systematic study of particle size and drug content","volume":"336","author":"Budhian","year":"2007","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.brainres.2019.05.040_b0035","doi-asserted-by":"crossref","first-page":"8744","DOI":"10.1038\/srep08744","article-title":"N-butylidenephthalide attenuates Alzheimer\u2019s disease-like cytopathy in Down syndrome induced pluripotent stem cell-derived neurons","volume":"5","author":"Chang","year":"2015","journal-title":"Sci. Rep."},{"key":"10.1016\/j.brainres.2019.05.040_b0040","doi-asserted-by":"crossref","first-page":"5349","DOI":"10.1073\/pnas.1317731111","article-title":"Glycogen synthase kinase 3 inhibitors induce the canonical WNT\/beta-catenin pathway to suppress growth and self-renewal in embryonal rhabdomyosarcoma","volume":"111","author":"Chen","year":"2014","journal-title":"Proc. Natl. Acad. Sci U.S.A"},{"key":"10.1016\/j.brainres.2019.05.040_b0045","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1038\/nmeth.1593","article-title":"Chemically defined conditions for human iPSC derivation and culture","volume":"8","author":"Chen","year":"2011","journal-title":"Nat. Methods"},{"key":"10.1016\/j.brainres.2019.05.040_b0050","doi-asserted-by":"crossref","first-page":"829","DOI":"10.3727\/096368913X675179","article-title":"Prerequisite OCT4 maintenance potentiates the neural induction of differentiating human embryonic stem cells and induced pluripotent stem cells","volume":"24","author":"Chen","year":"2015","journal-title":"Cell Transplant."},{"key":"10.1016\/j.brainres.2019.05.040_b0055","doi-asserted-by":"crossref","first-page":"10722","DOI":"10.1038\/s41598-018-28449-z","article-title":"Post-treatment with PT302, a long-acting Exendin-4 sustained release formulation, reduces dopaminergic neurodegeneration in a 6-Hydroxydopamine rat model of Parkinson\u2019s disease","volume":"8","author":"Chen","year":"2018","journal-title":"Sci. Rep."},{"key":"10.1016\/j.brainres.2019.05.040_b0060","doi-asserted-by":"crossref","first-page":"1351","DOI":"10.3727\/096368910X557173","article-title":"Enhanced survival of dopaminergic neuronal transplants in hemi-Parkinsonian rats by the p53 inactivator PFT-\u03b1","volume":"20","author":"Chou","year":"2011","journal-title":"Cell Transplant."},{"key":"10.1016\/j.brainres.2019.05.040_b0065","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0002622","article-title":"The tumorigenicity of mouse embryonic stem cells and in vitro differentiated neuronal cells is controlled by the recipients' immune response","volume":"3","author":"Dressel","year":"2008","journal-title":"PLoS One"},{"key":"10.1016\/j.brainres.2019.05.040_b0070","doi-asserted-by":"crossref","first-page":"2164","DOI":"10.1096\/fj.09-134957","article-title":"Pluripotent stem cells are highly susceptible targets for syngeneic, allogeneic, and xenogeneic natural killer cells","volume":"24","author":"Dressel","year":"2010","journal-title":"FASEB J."},{"key":"10.1016\/j.brainres.2019.05.040_b0075","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1186\/s13287-017-0529-y","article-title":"Intraarterial transplantation of human umbilical cord blood mononuclear cells in hyperacute stroke improves vascular function","volume":"8","author":"Huang","year":"2017","journal-title":"Stem Cell Res. Ther."},{"key":"10.1016\/j.brainres.2019.05.040_b0080","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1002\/jcb.22411","article-title":"Human ES and iPS cells as cell sources for the treatment of Parkinson\u2019s disease: current state and problems","volume":"109","author":"Hwang","year":"2010","journal-title":"J. Cell Biochem."},{"key":"10.1016\/j.brainres.2019.05.040_b0085","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0019025","article-title":"Transplantation of neuronal-primed human bone marrow mesenchymal stem cells in hemiparkinsonian rodents","volume":"6","author":"Khoo","year":"2011","journal-title":"PLoS One"},{"key":"10.1016\/j.brainres.2019.05.040_b9000","first-page":"64","article-title":"Generating regionalized neuronal cells from pluripotency, a step-by-step protocol","volume":"6","author":"Kirkeby","year":"2012","journal-title":"Front. Cell. Neurosci."},{"key":"10.1016\/j.brainres.2019.05.040_b0090","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1038\/nature10648","article-title":"Dopamine neurons derived from human ES cells efficiently engraft in animal models of Parkinson\u2019s disease","volume":"480","author":"Kriks","year":"2011","journal-title":"Nature"},{"key":"10.1016\/j.brainres.2019.05.040_b0095","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1177\/096368979900800604","article-title":"Xenografting human T2 sympathetic ganglion from hyperhidrotic patients partially restores catecholaminergic functions in hemi-Parkinsonian athymic rats","volume":"8","author":"Liu","year":"1999","journal-title":"Cell Transplant."},{"key":"10.1016\/j.brainres.2019.05.040_b0100","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1186\/1471-2202-11-127","article-title":"Cyclosporin A increases recovery after spinal cord injury but does not improve myelination by oligodendrocyte progenitor cell transplantation","volume":"11","author":"Lu","year":"2010","journal-title":"BMC. Neurosci."},{"key":"10.1016\/j.brainres.2019.05.040_b0105","series-title":"Encyclopedia of Movement Disorders","first-page":"49","article-title":"Rotation, drug-induced","author":"Luo","year":"2010"},{"key":"10.1016\/j.brainres.2019.05.040_b0110","doi-asserted-by":"crossref","first-page":"166","DOI":"10.2174\/157488408785747674","article-title":"Cyclosporin and organ specific toxicity: clinical aspects, pharmacogenetics and perspectives","volume":"3","author":"Magnasco","year":"2008","journal-title":"Curr. Clin. Pharmacol."},{"key":"10.1016\/j.brainres.2019.05.040_b0115","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1038\/nmeth.1591","article-title":"A more efficient method to generate integration-free human iPS cells","volume":"8","author":"Okita","year":"2011","journal-title":"Nat. Methods"},{"key":"10.1016\/j.brainres.2019.05.040_b0120","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1007\/BF02021528","article-title":"Cyclosporin A toxicity: MRI appearance of the brain","volume":"25","author":"Pace","year":"1995","journal-title":"Pediatr. Radiol."},{"key":"10.1016\/j.brainres.2019.05.040_b0125","doi-asserted-by":"crossref","first-page":"721","DOI":"10.3727\/096368914X685311","article-title":"Human umbilical cord blood cells induce neuroprotective change in gene expression profile in neurons after ischemia through activation of Akt pathway","volume":"24","author":"Shahaduzzaman","year":"2015","journal-title":"Cell Transplant."},{"key":"10.1016\/j.brainres.2019.05.040_b0130","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0114990","article-title":"Susceptibility of human embryonic stem cell-derived neural cells to Japanese encephalitis virus infection","volume":"9","author":"Shen","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.brainres.2019.05.040_b0135","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1006\/exnr.1995.1087","article-title":"Human ventromesencephalic grafts restore dopamine release and clearance in hemiparkinsonian rats","volume":"136","author":"Wang","year":"1995","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.brainres.2019.05.040_b0140","doi-asserted-by":"crossref","first-page":"124","DOI":"10.4103\/bc.bc_16_18","article-title":"Wharton\u2019 jelly mesenchymal stromal cell therapy for ischemic brain injury","volume":"4","author":"Wu","year":"2018","journal-title":"Brain Circ."},{"key":"10.1016\/j.brainres.2019.05.040_b0145","doi-asserted-by":"crossref","first-page":"1655","DOI":"10.1002\/stem.1152","article-title":"Specification of midbrain dopamine neurons from primate pluripotent stem cells","volume":"30","author":"Xi","year":"2012","journal-title":"Stem Cells"},{"key":"10.1016\/j.brainres.2019.05.040_b0150","doi-asserted-by":"crossref","first-page":"2599","DOI":"10.1161\/STROKEAHA.115.009870","article-title":"Neurorestorative therapy of stroke in type 2 diabetes mellitus rats treated with human umbilical cord blood cells","volume":"46","author":"Yan","year":"2015","journal-title":"Stroke"},{"key":"10.1016\/j.brainres.2019.05.040_b0155","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1080\/030097499442504","article-title":"Renal toxicity of long-term cyclosporin","volume":"28","author":"Zachariae","year":"1999","journal-title":"Scand. J. Rheumatol."},{"key":"10.1016\/j.brainres.2019.05.040_b0160","doi-asserted-by":"crossref","first-page":"925","DOI":"10.1634\/stemcells.22-6-925","article-title":"Dopaminergic differentiation of human embryonic stem cells","volume":"22","author":"Zeng","year":"2004","journal-title":"Stem Cells"}],"container-title":["Brain Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006899319302951?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006899319302951?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,13]],"date-time":"2025-09-13T18:02:00Z","timestamp":1757786520000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006899319302951"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,9]]},"references-count":33,"alternative-id":["S0006899319302951"],"URL":"https:\/\/doi.org\/10.1016\/j.brainres.2019.05.040","relation":{},"ISSN":["0006-8993"],"issn-type":[{"value":"0006-8993","type":"print"}],"subject":[],"published":{"date-parts":[[2019,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"NanoCsA improves the survival of human iPSC transplant in hemiparkinsonian rats","name":"articletitle","label":"Article Title"},{"value":"Brain Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.brainres.2019.05.040","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}