{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,30]],"date-time":"2026-08-30T02:46:28Z","timestamp":1788057988109,"version":"build-2784847793"},"reference-count":140,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,12,1]],"date-time":"2019-12-01T00:00:00Z","timestamp":1575158400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,12,1]],"date-time":"2019-12-01T00:00:00Z","timestamp":1575158400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Brain Research"],"published-print":{"date-parts":[[2019,12]]},"DOI":"10.1016\/j.brainres.2019.146397","type":"journal-article","created":{"date-parts":[[2019,8,20]],"date-time":"2019-08-20T01:56:19Z","timestamp":1566266179000},"page":"146397","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":37,"special_numbering":"C","title":["White matter loss and oligodendrocyte dysfunction in HIV: A consequence of the infection, the antiretroviral therapy or both?"],"prefix":"10.1016","volume":"1724","author":[{"given":"Brigid K.","family":"Jensen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lindsay M.","family":"Roth","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Judith B.","family":"Grinspan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kelly L.","family":"Jordan-Sciutto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.brainres.2019.146397_b0005","unstructured":"AIDSinfo, 2016. Panel on Antiretroviral Guidelines for Adults and Adolescents. Guidelines for the Use of Antiretroviral Agents in Adults and Adolescents with HIV. Department of Health and Human Services. Available at http:\/\/www.aidsinfo.nih.gov\/ContentFiles\/AdultandAdolescentGL.pdf. Accessed [May 30th 2019] [F-5, Table 6a]."},{"key":"10.1016\/j.brainres.2019.146397_b0010","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1007\/s13365-013-0227-1","article-title":"Antiretroviral drugs induce oxidative stress and neuronal damage in the central nervous system","volume":"20","author":"Akay","year":"2014","journal-title":"J. NeuroVirol."},{"key":"10.1016\/j.brainres.2019.146397_b0015","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1111\/j.1365-2990.2011.01215.x","article-title":"Activation status of integrated stress response pathways in neurones and astrocytes of HIV-associated neurocognitive disorders (HAND) cortex","volume":"38","author":"Akay","year":"2012","journal-title":"Neuropathol. Appl. Neurobiol."},{"key":"10.1016\/j.brainres.2019.146397_b0020","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1007\/s13365-018-0682-9","article-title":"White matter damage, neuroinflammation, and neuronal integrity in HAND","volume":"25","author":"Alakkas","year":"2019","journal-title":"J. NeuroVirol."},{"key":"10.1016\/j.brainres.2019.146397_b0025","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1093\/jnen\/64.6.529","article-title":"Influence of HAART on HIV-related CNS disease and neuroinflammation","volume":"64","author":"Anthony","year":"2005","journal-title":"J. Neuropathol. Exp. Neurol."},{"key":"10.1016\/j.brainres.2019.146397_b0030","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1002\/jnr.21462","article-title":"Bone morphogenetic proteins 4, 6, and 7 are up-regulated in mouse spinal cord during experimental autoimmune encephalomyelitis","volume":"86","author":"Ara","year":"2008","journal-title":"J. Neurosci. Res."},{"key":"10.1016\/j.brainres.2019.146397_b0035","doi-asserted-by":"crossref","first-page":"6241","DOI":"10.1523\/JNEUROSCI.18-16-06241.1998","article-title":"Maturation-dependent vulnerability of oligodendrocytes to oxidative stress-induced death caused by glutathione depletion","volume":"18","author":"Back","year":"1998","journal-title":"J. Neurosci."},{"key":"10.1016\/j.brainres.2019.146397_b0040","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1523\/JNEUROSCI.22-02-00455.2002","article-title":"Selective vulnerability of late oligodendrocyte progenitors to hypoxia-ischemia","volume":"22","author":"Back","year":"2002","journal-title":"J. Neurosci."},{"key":"10.1016\/j.brainres.2019.146397_b0045","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1111\/j.0953-816X.2004.03451.x","article-title":"Developmental up-regulation of MnSOD in rat oligodendrocytes confers protection against oxidative injury","volume":"20","author":"Baud","year":"2004","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.brainres.2019.146397_b0050","doi-asserted-by":"crossref","first-page":"4076","DOI":"10.2174\/138161211798764951","article-title":"Oxidative stress and mitochondrial impairment after treatment with anti-HIV drugs: clinical implications","volume":"17","author":"Blas-Garcia","year":"2011","journal-title":"Curr. Pharm. Des."},{"key":"10.1016\/j.brainres.2019.146397_b0055","doi-asserted-by":"crossref","first-page":"1925","DOI":"10.1073\/pnas.94.5.1925","article-title":"The HIV coreceptors CXCR4 and CCR5 are differentially expressed and regulated on human T lymphocytes","volume":"94","author":"Bleul","year":"1997","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1016\/j.brainres.2019.146397_b0060","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1007\/s11481-009-9167-1","article-title":"Gene expression profiles of HIV-1-infected glia and brain: toward better understanding of the role of astrocytes in HIV-1-associated neurocognitive disorders","volume":"5","author":"Borjabad","year":"2010","journal-title":"J. Neuroimmune Pharmacol."},{"key":"10.1016\/j.brainres.2019.146397_b0065","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1186\/s12985-015-0298-0","article-title":"HIV infection and antiretroviral therapy lead to unfolded protein response activation","volume":"12","author":"Borsa","year":"2015","journal-title":"Virol. J."},{"key":"10.1016\/j.brainres.2019.146397_b0070","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1186\/1750-1326-9-58","article-title":"Associations between brain microstructures, metabolites, and cognitive deficits during chronic HIV-1 infection of humanized mice","volume":"9","author":"Boska","year":"2014","journal-title":"Mol. Neurodegener."},{"key":"10.1016\/j.brainres.2019.146397_b0075","doi-asserted-by":"crossref","first-page":"260","DOI":"10.3389\/fimmu.2018.00260","article-title":"Mechanisms for Cell-to-Cell Transmission of HIV-1","volume":"9","author":"Bracq","year":"2018","journal-title":"Front. Immunol."},{"key":"10.1016\/j.brainres.2019.146397_b0080","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1111\/j.1471-4159.2011.07544.x","article-title":"The antiretroviral protease inhibitors indinavir and nelfinavir stimulate Mrp1-mediated GSH export from cultured brain astrocytes","volume":"120","author":"Brandmann","year":"2012","journal-title":"J. Neurochem."},{"key":"10.1016\/j.brainres.2019.146397_b0085","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1097\/00002030-200401001-00011","article-title":"Evidence for a change in AIDS dementia complex in the era of highly active antiretroviral therapy and the possibility of new forms of AIDS dementia complex","volume":"18","author":"Brew","year":"2004","journal-title":"AIDS"},{"key":"10.1016\/j.brainres.2019.146397_b0090","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pbio.1002605","article-title":"Oligodendroglial myelination requires astrocyte-derived lipids","volume":"15","author":"Camargo","year":"2017","journal-title":"PLoS Biol."},{"key":"10.1016\/j.brainres.2019.146397_b0095","doi-asserted-by":"crossref","first-page":"R622","DOI":"10.1016\/j.cub.2012.07.004","article-title":"Unfolded protein response","volume":"22","author":"Cao","year":"2012","journal-title":"Curr. Biol."},{"key":"10.1016\/j.brainres.2019.146397_b0100","doi-asserted-by":"crossref","unstructured":"Carr, A., Samaras, K., Chisholm, D., Lancet, C.D., 1998. Pathogenesis of HIV-1-protease inhibitor-associated peripheral lipodystrophy, hyperlipidaemia, and insulin resistance. doi: 10.1016\/S0140-6736(98)03391-1.","DOI":"10.1016\/S0140-6736(98)03391-1"},{"key":"10.1016\/j.brainres.2019.146397_b0105","doi-asserted-by":"crossref","first-page":"442","DOI":"10.3181\/0811-RM-317","article-title":"HIV-1 protease inhibitor induced oxidative stress suppresses glucose stimulated insulin release: protection with thymoquinone","volume":"234","author":"Chandra","year":"2009","journal-title":"Exp. Biol. Med."},{"key":"10.1016\/j.brainres.2019.146397_b0110","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1038\/ejhg.2015.120","article-title":"Myelination-related genes are associated with decreased white matter integrity in schizophrenia","volume":"24","author":"Chavarria-Siles","year":"2016","journal-title":"Eur. J. Hum. Genet."},{"key":"10.1016\/j.brainres.2019.146397_b0115","doi-asserted-by":"crossref","first-page":"13193","DOI":"10.1073\/pnas.94.24.13193","article-title":"Presence of an inducible HIV-1 latent reservoir during highly active antiretroviral therapy","volume":"94","author":"Chun","year":"1997","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1016\/j.brainres.2019.146397_b0120","doi-asserted-by":"crossref","first-page":"594","DOI":"10.1016\/j.brainres.2016.03.046","article-title":"Endoplasmic reticulum stress and the unfolded protein response in disorders of myelinating glia","volume":"1648","author":"Clayton","year":"2016","journal-title":"Brain Res."},{"issue":"528\u201332","key":"10.1016\/j.brainres.2019.146397_b0125","first-page":"537","article-title":"Ritonavir-boosted protease inhibitors, Part 2: cardiac implications of lipid alterations","volume":"15","author":"Cohen","year":"2005","journal-title":"The AIDS reader"},{"key":"10.1016\/j.brainres.2019.146397_b0130","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1007\/s00234-015-1489-5","article-title":"Diffusion tensor MR imaging of white matter integrity in HIV-positive patients with planning deficit","volume":"57","author":"Corr\u00eaa","year":"2015","journal-title":"Neuroradiology"},{"key":"10.1016\/j.brainres.2019.146397_b0135","article-title":"Axonal loss in multiple sclerosis: causes and mechanisms","author":"Criste","year":"2014","journal-title":"Handb. Clin. Neurol."},{"key":"10.1016\/j.brainres.2019.146397_b0140","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1046\/j.1529-8027.2001.006001014.x","article-title":"Peripheral neuropathy and antiretroviral drugs","volume":"6","author":"Dalakas","year":"2001","journal-title":"J. Peripheral Nervous System"},{"key":"10.1016\/j.brainres.2019.146397_b0145","doi-asserted-by":"crossref","first-page":"4788","DOI":"10.4049\/jimmunol.1004111","article-title":"Neuroinflammation and endoplasmic reticulum stress are coregulated by crocin to prevent demyelination and neurodegeneration","volume":"187","author":"Deslauriers","year":"2011","journal-title":"J. Immunol."},{"key":"10.1016\/j.brainres.2019.146397_b0150","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1002\/jnr.20063","article-title":"The myelinated axon is dependent on the myelinating cell for support and maintenance: molecules involved","volume":"76","author":"Edgar","year":"2004","journal-title":"J. Neurosci. Res."},{"key":"10.1016\/j.brainres.2019.146397_b0155","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1038\/nrn2040","article-title":"HIV and antiretroviral therapy in the brain: neuronal injury and repair","volume":"8","author":"Ellis","year":"2007","journal-title":"Nat. Rev. Neurosci."},{"issue":"566\u2013572","key":"10.1016\/j.brainres.2019.146397_b0160","first-page":"2008","article-title":"Human immunodeficiency virus protease inhibitors and risk for peripheral neuropathy","volume":"64","author":"Ellis","year":"2008","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.brainres.2019.146397_b0165","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1111\/j.1750-3639.1999.tb00219.x","article-title":"Cortical synaptic density is reduced in mild to moderate human immunodeficiency virus neurocognitive disorder. HNRC Group. HIV Neurobehavioral Research Center","volume":"9","author":"Everall","year":"1999","journal-title":"Brain Pathol. (Zurich, Switzerland)"},{"key":"10.1016\/j.brainres.2019.146397_b0170","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1007\/BF03033819","article-title":"The shifting patterns of HIV encephalitis neuropathology","volume":"8","author":"Everall","year":"2005","journal-title":"Neurotox. Res."},{"key":"10.1016\/j.brainres.2019.146397_b0175","doi-asserted-by":"crossref","first-page":"360","DOI":"10.3109\/13550280903131915","article-title":"Cliniconeuropathologic correlates of human immunodeficiency virus in the era of antiretroviral therapy","volume":"15","author":"Everall","year":"2009","journal-title":"J. NeuroVirol."},{"key":"10.1016\/j.brainres.2019.146397_b0180","doi-asserted-by":"crossref","first-page":"1571","DOI":"10.1101\/gad.1806309","article-title":"Dysregulation of the Wnt pathway inhibits timely myelination and remyelination in the mammalian CNS","volume":"23","author":"Fancy","year":"2009","journal-title":"Genes Dev."},{"key":"10.1016\/j.brainres.2019.146397_b0185","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1016\/j.mcn.2009.07.010","article-title":"Wnt signaling is sufficient to perturb oligodendrocyte maturation","volume":"42","author":"Feigenson","year":"2009","journal-title":"Mol. Cell. Neurosci."},{"key":"10.1016\/j.brainres.2019.146397_b0190","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1523\/JNEUROSCI.20-01-00034.2000","article-title":"Rapid ischemic cell death in immature oligodendrocytes: a fatal glutamate release feedback loop","volume":"20","author":"Fern","year":"2000","journal-title":"J. Neurosci."},{"key":"10.1016\/j.brainres.2019.146397_b0195","doi-asserted-by":"crossref","first-page":"6612","DOI":"10.1016\/j.febslet.2006.11.016","article-title":"Protective effect of acetyl\u2010l\u2010carnitine against oxidative stress induced by antiretroviral drugs","volume":"580","author":"Ferraresi","year":"2006","journal-title":"FEBS Lett."},{"key":"10.1016\/j.brainres.2019.146397_b0200","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1007\/s11481-013-9520-2","article-title":"Role of neurotrophic factor alterations in the neurodegenerative process in HIV associated neurocognitive disorders","volume":"9","author":"Fields","year":"2014","journal-title":"J. Neuroimmune Pharmacol."},{"key":"10.1016\/j.brainres.2019.146397_b0205","doi-asserted-by":"crossref","first-page":"1295","DOI":"10.1126\/science.278.5341.1295","article-title":"Identification of a reservoir for HIV-1 in patients on highly active antiretroviral therapy","volume":"278","author":"Finzi","year":"1997","journal-title":"Science"},{"key":"10.1016\/j.brainres.2019.146397_b0210","doi-asserted-by":"crossref","first-page":"990","DOI":"10.1093\/jnen\/63.9.990","article-title":"Developmental lag in superoxide dismutases relative to other antioxidant enzymes in premyelinated human telencephalic white matter","volume":"63","author":"Folkerth","year":"2004","journal-title":"J. Neuropathol. Exp. Neurol."},{"key":"10.1016\/j.brainres.2019.146397_b0215","doi-asserted-by":"crossref","first-page":"3076","DOI":"10.1002\/jnr.22139","article-title":"Oxidative stress disrupts oligodendrocyte maturation","volume":"87","author":"French","year":"2009","journal-title":"J. Neurosci. Res."},{"key":"10.1016\/j.brainres.2019.146397_b0220","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.ajpath.2016.09.006","article-title":"HIV protease inhibitors alter amyloid precursor protein processing via \u03b2-site amyloid precursor protein cleaving enzyme-1 translational up-regulation","volume":"187","author":"Gannon","year":"2017","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.brainres.2019.146397_b0225","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1007\/s00018-006-6182-8","article-title":"Pelizaeus-Merzbacher disease: genetic and cellular pathogenesis","volume":"64","author":"Garbern","year":"2007","journal-title":"Cell. Mol. Life Sci."},{"key":"10.1016\/j.brainres.2019.146397_b0230","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1002\/glia.20406","article-title":"Rafts in oligodendrocytes: evidence and structure\u2013function relationship","volume":"54","author":"Gielen","year":"2006","journal-title":"Glia"},{"key":"10.1016\/j.brainres.2019.146397_b0235","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1007\/s00415-004-0348-9","article-title":"The role of oxidative stress in the pathogenesis of multiple sclerosis: the need for effective antioxidant therapy","volume":"251","author":"Gilgun-Sherki","year":"2004","journal-title":"J. Neurol."},{"key":"10.1016\/j.brainres.2019.146397_b0240","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1002\/ana.410380510","article-title":"Immunocytochemical quantitation of human immunodeficiency virus in the brain: correlations with dementia","volume":"38","author":"Glass","year":"1995","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.brainres.2019.146397_b0245","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1007\/s13365-011-0055-0","article-title":"Clinical contributors to cerebral white matter integrity in HIV-infected individuals","volume":"17","author":"Gongvatana","year":"2011","journal-title":"J. NeuroVirol."},{"key":"10.1016\/j.brainres.2019.146397_b0250","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1038\/nri1527","article-title":"The neuropathogenesis of AIDS","volume":"5","author":"Gonz\u00e1lez-Scarano","year":"2005","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.brainres.2019.146397_b0255","first-page":"146","article-title":"Neuropathology and neurodegeneration in human immunodeficiency virus infection. Pathogenesis of HIV-induced lesions of the brain, correlations with HIV-associated disorders and modifications according to treatments","volume":"20","author":"Gray","year":"2001","journal-title":"Clin. Neuropathol."},{"key":"10.1016\/j.brainres.2019.146397_b0260","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1093\/jnen\/62.5.429","article-title":"The Changing pattern of HIV neuropathology in the HAART era","volume":"62","author":"Gray","year":"2003","journal-title":"J. Neuropathol. Exp. Neurol."},{"key":"10.1016\/j.brainres.2019.146397_b0265","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1750-3639.1996.tb00775.x","article-title":"Neuropathology of early HIV-1 infection","volume":"6","author":"Gray","year":"1996","journal-title":"Brain Pathol."},{"key":"10.1016\/j.brainres.2019.146397_b0270","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1093\/jnen\/61.4.297","article-title":"Cells and signaling in oligodendrocyte development","volume":"61","author":"Grinspan","year":"2002","journal-title":"J. Neuropathol. Exp. Neurol."},{"key":"10.1016\/j.brainres.2019.146397_b0275","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/(SICI)1097-4695(200004)43:1<1::AID-NEU1>3.0.CO;2-0","article-title":"Stage-specific effects of bone morphogenetic proteins on the oligodendrocyte lineage","volume":"43","author":"Grinspan","year":"2000","journal-title":"J. Neurobiol."},{"key":"10.1016\/j.brainres.2019.146397_b0280","doi-asserted-by":"crossref","unstructured":"Gupta, A., Li, B., Cerniglia, G., Ahmed, Neoplasia, H., 2007. The HIV protease inhibitor nelfinavir downregulates Akt phosphorylation by inhibiting proteasomal activity and inducing the unfolded protein response. doi: 10.1593\/neo.07124.","DOI":"10.1593\/neo.07124"},{"key":"10.1016\/j.brainres.2019.146397_b0285","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1093\/jnen\/62.5.441","article-title":"Nitrosative and oxidative injury to premyelinating oligodendrocytes in periventricular leukomalacia","volume":"62","author":"Haynes","year":"2003","journal-title":"J. Neuropathol. Exp. Neurol."},{"key":"10.1016\/j.brainres.2019.146397_b0290","doi-asserted-by":"crossref","first-page":"2087","DOI":"10.1212\/WNL.0b013e318200d727","article-title":"HIV-associated neurocognitive disorders persist in the era of potent antiretroviral therapy: CHARTER Study","volume":"75","author":"Heaton","year":"2010","journal-title":"Neurology"},{"key":"10.1016\/j.brainres.2019.146397_b0295","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1007\/s13365-010-0006-1","article-title":"HIV-associated neurocognitive disorders before and during the era of combination antiretroviral therapy: differences in rates, nature, and predictors","volume":"17","author":"Heaton","year":"2011","journal-title":"J. NeuroVirol."},{"key":"10.1016\/j.brainres.2019.146397_b0300","doi-asserted-by":"crossref","first-page":"16306","DOI":"10.1523\/JNEUROSCI.3145-12.2012","article-title":"Human immunodeficiency virus type 1 (HIV-1) transactivator of transcription through its intact core and cysteine-rich domains inhibits Wnt\/\u03b2-catenin signaling in astrocytes: relevance to HIV neuropathogenesis","volume":"32","author":"Henderson","year":"2012","journal-title":"J. Neurosci."},{"key":"10.1016\/j.brainres.2019.146397_b0305","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1176\/jnp.2010.22.3.313","article-title":"White matter correlates of apathy in HIV-positive subjects: a diffusion tensor imaging study","volume":"22","author":"Hoare","year":"2010","journal-title":"J. Neuropsychiatry"},{"key":"10.1016\/j.brainres.2019.146397_b0310","doi-asserted-by":"crossref","first-page":"7","DOI":"10.3389\/fmolb.2017.00007","article-title":"Cellular pathology of Pelizaeus-Merzbacher disease involving chaperones associated with endoplasmic reticulum stress","volume":"4","author":"Inoue","year":"2017","journal-title":"Front. Mol. Biosci."},{"key":"10.1016\/j.brainres.2019.146397_b0315","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1007\/s12035-009-8071-2","article-title":"Myelin proteomics: molecular anatomy of an insulating sheath","volume":"40","author":"Jahn","year":"2009","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.brainres.2019.146397_b0320","doi-asserted-by":"crossref","first-page":"1093","DOI":"10.1097\/NEN.0000000000000255","article-title":"Altered oligodendrocyte maturation and myelin maintenance: the role of antiretrovirals in HIV-associated neurocognitive disorders","volume":"74","author":"Jensen","year":"2015","journal-title":"J. Neuropathol. Exp. Neurol."},{"key":"10.1016\/j.brainres.2019.146397_b0325","doi-asserted-by":"crossref","first-page":"nm781","DOI":"10.1038\/nm781","article-title":"Multiple sclerosis: re-expression of a developmental pathway that restricts oligodendrocyte maturation","volume":"8","author":"John","year":"2002","journal-title":"Nat. Med."},{"key":"10.1016\/j.brainres.2019.146397_b0330","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1038\/nn.3357","article-title":"Degeneration and impaired regeneration of gray matter oligodendrocytes in amyotrophic lateral sclerosis","volume":"16","author":"Kang","year":"2013","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.brainres.2019.146397_b0335","doi-asserted-by":"crossref","first-page":"4401623","DOI":"10.1038\/sj.cdd.4401623","article-title":"HIV-1 infection and AIDS: consequences for the central nervous system","volume":"12","author":"Kaul","year":"2005","journal-title":"Cell Death Differ."},{"key":"10.1016\/j.brainres.2019.146397_b0340","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1007\/s13365-014-0261-7","article-title":"Early suppressive antiretroviral therapy in HIV infection is associated with measurable changes in the corpus callosum","volume":"20","author":"Kelly","year":"2014","journal-title":"Journal of NeuroVirology"},{"key":"10.1016\/j.brainres.2019.146397_b0345","article-title":"Current perspectives in HIV infection","author":"King","year":"2013","journal-title":"IntechOpen"},{"key":"10.1016\/j.brainres.2019.146397_b0350","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1177\/135965350701200407","article-title":"Some HIV antiretrovirals increase oxidative stress and alter chemokine, cytokine or adiponectin production in human adipocytes and macrophages","volume":"12","author":"Lagathu","year":"2007","journal-title":"Antiviral Therapy"},{"key":"10.1016\/j.brainres.2019.146397_b0355","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1111\/j.1750-3639.2003.tb00019.x","article-title":"Changing patterns in the neuropathogenesis of HIV during the HAART era","volume":"13","author":"Langford","year":"2003","journal-title":"Brain Pathol. (Zurich, Switzerland)"},{"key":"10.1016\/j.brainres.2019.146397_b0360","doi-asserted-by":"crossref","first-page":"ng1095","DOI":"10.1038\/ng1095","article-title":"Disruption of Cnp1 uncouples oligodendroglial functions in axonal support and myelination","volume":"33","author":"Lappe-Siefke","year":"2003","journal-title":"Nat. Genet."},{"key":"10.1016\/j.brainres.2019.146397_b0365","doi-asserted-by":"crossref","first-page":"1488","DOI":"10.1002\/jmri.24129","article-title":"Diffusion tensor MRI evaluation of the corona radiata, cingulate gyri, and corpus callosum in HIV patients","volume":"38","author":"Leite","year":"2013","journal-title":"J. Magn. Reson. Imaging"},{"key":"10.1016\/j.brainres.2019.146397_b0370","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0105752","article-title":"Diffusion tensor and volumetric magnetic resonance measures as biomarkers of brain damage in a small animal model of HIV","volume":"9","author":"Lentz","year":"2014","journal-title":"PLoS ONE"},{"key":"10.1016\/j.brainres.2019.146397_b0375","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1159\/000046149","article-title":"Hypoxia\/ischemia depletes the rat perinatal subventricular zone of oligodendrocyte progenitors and neural stem cells","volume":"23","author":"Levison","year":"2001","journal-title":"Dev. Neurosci."},{"key":"10.1016\/j.brainres.2019.146397_b0380","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/j.cortex.2015.02.008","article-title":"Multimodal neuroimaging based classification of autism spectrum disorder using anatomical, neurochemical, and white matter correlates","volume":"66","author":"Libero","year":"2015","journal-title":"Cortex"},{"key":"10.1016\/j.brainres.2019.146397_b0385","article-title":"Transcriptome sequencing of gene expression in the brain of the HIV-1 transgenic rat","volume":"8","author":"Li","year":"2013","journal-title":"PLoS ONE"},{"key":"10.1016\/j.brainres.2019.146397_b0390","doi-asserted-by":"crossref","first-page":"658","DOI":"10.1111\/j.1365-2990.2007.00866.x","article-title":"Expression of the endoplasmic reticulum stress response marker, BiP, in the central nervous system of HIV-positive individuals","volume":"33","author":"Lindl","year":"2007","journal-title":"Neuropathol. Appl. Neurobiol."},{"key":"10.1016\/j.brainres.2019.146397_b0395","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1007\/s11481-010-9205-z","article-title":"HIV-associated neurocognitive disorder: pathogenesis and therapeutic opportunities","volume":"5","author":"Lindl","year":"2010","journal-title":"J. Neuroimmune Pharmacol."},{"key":"10.1016\/j.brainres.2019.146397_b0400","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1038\/nn.2273","article-title":"Endoplasmic reticulum stress in disorders of myelinating cells","volume":"12","author":"Lin","year":"2009","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.brainres.2019.146397_b0405","doi-asserted-by":"crossref","first-page":"1682","DOI":"10.1016\/S0140-6736(97)10291-4","article-title":"Long-lasting recovery in CD4 T-cell function and viral-load reduction after highly active antiretroviral therapy in advanced HIV-1 disease","volume":"351","author":"Li","year":"1998","journal-title":"The Lancet"},{"key":"10.1016\/j.brainres.2019.146397_b0410","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.nbd.2016.10.007","article-title":"Human immunodeficiency virus protein Tat induces oligodendrocyte injury by enhancing outward K+ current conducted by KV1.3","volume":"97","author":"Liu","year":"2017","journal-title":"Neurobiol. Disease"},{"key":"10.1016\/j.brainres.2019.146397_b0415","first-page":"1489","article-title":"Systemic HIV-1 infection produces a unique glial footprint in humanized mouse brains","volume":"10","author":"Li","year":"2017","journal-title":"Disease Models Mech."},{"key":"10.1016\/j.brainres.2019.146397_b0420","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1016\/j.freeradbiomed.2010.12.029","article-title":"Highly active antiretroviral therapy drug combination induces oxidative stress and mitochondrial dysfunction in immortalized human blood\u2013brain barrier endothelial","volume":"50","author":"Manda","year":"2011","journal-title":"Free Radical Biol. Med."},{"key":"10.1016\/j.brainres.2019.146397_b0425","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.jchromb.2005.04.023","article-title":"Oxidative stress in brain aging, neurodegenerative and vascular diseases: an overview","volume":"827","author":"Mariani","year":"2005","journal-title":"J. Chromatogr. B"},{"key":"10.1016\/j.brainres.2019.146397_b0430","first-page":"s294","article-title":"Multiple sclerosis update","volume":"19","author":"Markowitz","year":"2013","journal-title":"Am. J. Managed Care"},{"key":"10.1016\/j.brainres.2019.146397_b0435","doi-asserted-by":"crossref","first-page":"963","DOI":"10.1002\/ana.410420618","article-title":"Dendritic injury is a pathological substrate for human immunodeficiency virus-related cognitive disorders","volume":"42","author":"Masliah","year":"1997","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.brainres.2019.146397_b0440","doi-asserted-by":"crossref","first-page":"544","DOI":"10.1034\/j.1600-0714.2003.00159.x","article-title":"Salivary gland disease in HIV\/AIDS and primary Sj\u00f6gren\u2019s Syndrome: analysis of collagen I distribution and histopathology in American and African patients","volume":"32","author":"McArthur","year":"2003","journal-title":"J. Oral Pathol. Med."},{"key":"10.1016\/j.brainres.2019.146397_b0445","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1002\/ana.22053","article-title":"Human immunodeficiency virus-associated neurocognitive disorders: mind the gap","volume":"67","author":"McArthur","year":"2010","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.brainres.2019.146397_b0450","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/S0733-8619(18)30060-4","article-title":"Oligodendrocytes and myelin","volume":"13","author":"McLaurin","year":"1995","journal-title":"Neurol. Clin."},{"key":"10.1016\/j.brainres.2019.146397_b0455","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1016\/j.ygyno.2008.11.028","article-title":"The HIV protease inhibitor saquinavir induces endoplasmic reticulum stress, autophagy, and apoptosis in ovarian cancer cells","volume":"112","author":"McLean","year":"2009","journal-title":"Gynecol. Oncol."},{"key":"10.1016\/j.brainres.2019.146397_b0460","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1016\/j.neulet.2013.05.010","article-title":"FGF2 and FGFR1 signaling regulate functional recovery following cuprizone demyelination","volume":"548","author":"Mierzwa","year":"2013","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.brainres.2019.146397_b0465","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/j.schres.2014.09.040","article-title":"Myelin, myelin-related disorders, and psychosis","volume":"161","author":"Mighdoll","year":"2015","journal-title":"Schizophr. Res."},{"key":"10.1016\/j.brainres.2019.146397_b0470","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1016\/S0301-0082(02)00058-8","article-title":"Regulation of oligodendrocyte development in the vertebrate CNS","volume":"67","author":"Miller","year":"2002","journal-title":"Prog. Neurobiol."},{"key":"10.1016\/j.brainres.2019.146397_b0475","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1007\/s11481-013-9488-y","article-title":"Implementing neuronal plasticity in NeuroAIDS: the experience of brain-derived neurotrophic factor and other neurotrophic factors","volume":"9","author":"Mocchetti","year":"2014","journal-title":"J. Neuroimmune Pharmacol."},{"key":"10.1016\/j.brainres.2019.146397_b0480","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1385\/CT:4:3:287","article-title":"HAART drugs induce oxidative stress in human endothelial cells and increase endothelial recruitment of mononuclear cells","volume":"4","author":"Mondal","year":"2004","journal-title":"Cardiovasc. Toxicol."},{"key":"10.1016\/j.brainres.2019.146397_b0485","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1111\/jnc.13721","article-title":"Reduced sterol regulatory element-binding protein (SREBP) processing through site-1 protease (S1P) inhibition alters oligodendrocyte differentiation in vitro","volume":"140","author":"Monnerie","year":"2017","journal-title":"J. Neurochem."},{"key":"10.1016\/j.brainres.2019.146397_b0490","doi-asserted-by":"crossref","first-page":"1133","DOI":"10.1016\/j.neuropsychologia.2009.12.015","article-title":"Callosal degradation in HIV-1 infection predicts hierarchical perception: a DTI study","volume":"48","author":"M\u00fcller-Oehring","year":"2010","journal-title":"Neuropsychologia"},{"key":"10.1016\/j.brainres.2019.146397_b0495","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.jns.2007.09.032","article-title":"The role of SVZ-derived neural precursors in demyelinating diseases: From animal models to multiple sclerosis","volume":"265","author":"Nait-Oumesmar","year":"2008","journal-title":"J. Neurol. Sci."},{"key":"10.1016\/j.brainres.2019.146397_b0500","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1002\/ana.410190603","article-title":"The AIDS dementia complex: II. Neuropathology","volume":"19","author":"Navia","year":"1986","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.brainres.2019.146397_b0505","doi-asserted-by":"crossref","first-page":"1510","DOI":"10.3174\/ajnr.A5229","article-title":"Reliability of white matter microstructural changes in HIV infection: meta-analysis and confirmation","volume":"38","author":"O\u2019Connor","year":"2017","journal-title":"Am. J. Neuroradiol."},{"key":"10.1016\/j.brainres.2019.146397_b0510","doi-asserted-by":"crossref","first-page":"981","DOI":"10.1523\/JNEUROSCI.4617-05.2006","article-title":"Human immunodeficiency virus (HIV)-induced neurotoxicity: roles for the NMDA receptor subtypes","volume":"26","author":"O\u2019Donnell","year":"2006","journal-title":"J. Neurosci."},{"key":"10.1016\/j.brainres.2019.146397_b0515","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1007\/s11883-008-0010-6","article-title":"HIV therapy, metabolic syndrome, and cardiovascular risk","volume":"10","author":"Pao","year":"2008","journal-title":"Current Atherosclerosis Reports"},{"key":"10.1016\/j.brainres.2019.146397_b0520","doi-asserted-by":"crossref","first-page":"1909","DOI":"10.1124\/mol.104.010165","article-title":"Endoplasmic reticulum stress links dyslipidemia to inhibition of proteasome activity and glucose transport by HIV protease inhibitors","volume":"67","author":"Parker","year":"2005","journal-title":"Mol. Pharmacol."},{"key":"10.1016\/j.brainres.2019.146397_b0525","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1111\/j.1600-065X.2006.00440.x","article-title":"Immune privilege and HIV-1 persistence in the CNS","volume":"213","author":"Persidsky","year":"2006","journal-title":"Immunol. Rev."},{"key":"10.1016\/j.brainres.2019.146397_b0530","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1097\/00005072-198611000-00003","article-title":"Neuropathology of acquired immunodeficiency syndrome (AIDS): an autopsy review","volume":"45","author":"Petito","year":"1986","journal-title":"J. Neuropathol. Exp. Neurol."},{"key":"10.1016\/j.brainres.2019.146397_b0535","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/0962-8924(93)90213-K","article-title":"The oligodendrocyte and its many cellular processes","volume":"3","author":"Pfeiffer","year":"1993","journal-title":"Trends Cell Biol."},{"key":"10.1016\/j.brainres.2019.146397_b0540","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/S0925-4927(00)00082-2","article-title":"White matter abnormalities in HIV-1 infection: a diffusion tensor imaging study","volume":"106","author":"Pomara","year":"2001","journal-title":"Psychiatry Res.: Neuroimaging"},{"key":"10.1016\/j.brainres.2019.146397_b0545","doi-asserted-by":"crossref","first-page":"303390a0","DOI":"10.1038\/303390a0","article-title":"A glial progenitor cell that develops in vitro into an astrocyte or an oligodendrocyte depending on culture medium","volume":"303","author":"Raff","year":"1983","journal-title":"Nature"},{"key":"10.1016\/j.brainres.2019.146397_b0550","first-page":"195","article-title":"Whole brain diffusion tensor imaging in HIV-associated cognitive impairment","volume":"25","author":"Ragin","year":"2004","journal-title":"Am. J. Neuroradiol."},{"key":"10.1016\/j.brainres.2019.146397_b0555","doi-asserted-by":"crossref","first-page":"640","DOI":"10.1097\/NEN.0b013e31825cfa81","article-title":"Delayed myelination in an intrauterine growth retardation model is mediated by oxidative stress upregulating bone morphogenetic protein 4","volume":"71","author":"Reid","year":"2012","journal-title":"J. Neuropathol. Exp. Neurol."},{"key":"10.1016\/j.brainres.2019.146397_b0560","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1016\/j.jneuroim.2016.01.022","article-title":"Characterization of neuropathology in the HIV-1 transgenic rat at different ages","volume":"292","author":"Reid","year":"2016","journal-title":"J. Neuroimmunol."},{"key":"10.1016\/j.brainres.2019.146397_b0565","doi-asserted-by":"crossref","first-page":"9271","DOI":"10.1073\/pnas.161290298","article-title":"An HIV-1 transgenic rat that develops HIV-related pathology and immunologic dysfunction","volume":"98","author":"Reid","year":"2001","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1016\/j.brainres.2019.146397_b0570","doi-asserted-by":"crossref","first-page":"37514","DOI":"10.1074\/jbc.M104557200","article-title":"HIV protease inhibitor induces fatty acid and sterol biosynthesis in liver and adipose tissues due to the accumulation of activated sterol regulatory element-binding proteins in the nucleus","volume":"276","author":"Riddle","year":"2001","journal-title":"J. Biol. Chem."},{"issue":"Suppl. 15","key":"10.1016\/j.brainres.2019.146397_b0575","first-page":"S29","article-title":"Oxidative stress and aging","volume":"23","author":"Romano","year":"2010","journal-title":"J. Nephrol."},{"key":"10.1016\/j.brainres.2019.146397_b0580","doi-asserted-by":"crossref","DOI":"10.1038\/nrm2199","article-title":"Signal integration in the endoplasmic reticulum unfolded protein response","author":"Ron","year":"2007","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.brainres.2019.146397_b0585","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1097\/COH.0000000000000102","article-title":"Evolving clinical phenotypes in HIV-associated neurocognitive disorders","volume":"9","author":"Sacktor","year":"2014","journal-title":"Curr. Opin. HIV and AIDS"},{"key":"10.1016\/j.brainres.2019.146397_b0590","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1038\/nrneurol.2016.27","article-title":"HIV-associated neurocognitive disorder \u2013 pathogenesis and prospects for treatment","volume":"12","author":"Saylor","year":"2016","journal-title":"Nature Rev. Neurol."},{"issue":"Suppl.","key":"10.1016\/j.brainres.2019.146397_b0595","doi-asserted-by":"crossref","first-page":"S108","DOI":"10.1002\/ana.410230727","article-title":"Comparison of simian immunodeficiency virus and human immunodeficiency virus encephalitides in the immature host","volume":"23","author":"Sharer","year":"1988","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.brainres.2019.146397_b0600","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1016\/S0896-6273(02)01045-0","article-title":"The unfolded protein response modulates disease severity in Pelizaeus-Merzbacher disease","volume":"36","author":"Southwood","year":"2002","journal-title":"Neuron"},{"key":"10.1016\/j.brainres.2019.146397_b0605","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1038\/ncb1682","article-title":"Membrane nanotubes physically connect T cells over long distances presenting a novel route for HIV-1 transmission","volume":"10","author":"Sowinski","year":"2008","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.brainres.2019.146397_b0610","doi-asserted-by":"crossref","first-page":"4288","DOI":"10.1523\/JNEUROSCI.1280-17.2018","article-title":"BACE1 mediates HIV-associated and excitotoxic neuronal damage through an APP-dependent mechanism","volume":"38","author":"Stern","year":"2018","journal-title":"J. Neurosci."},{"key":"10.1016\/j.brainres.2019.146397_b0615","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1007\/s11481-017-9761-6","article-title":"Differential effects of antiretroviral drugs on neurons in vitro: roles for oxidative stress and integrated stress response","volume":"13","author":"Stern","year":"2018","journal-title":"J. Neuroimmune Pharmacol."},{"key":"10.1016\/j.brainres.2019.146397_b0620","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1007\/s11682-009-9086-z","article-title":"Quantitative diffusion tensor imaging tractography metrics are associated with cognitive performance among HIV-infected patients","volume":"4","author":"Tate","year":"2010","journal-title":"Brain Imaging Behav."},{"key":"10.1016\/j.brainres.2019.146397_b0625","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1007\/s13365-011-0033-6","article-title":"Regional areas and widths of the midsagittal corpus callosum among HIV-infected patients on stable antiretroviral therapies","volume":"17","author":"Tate","year":"2011","journal-title":"J. NeuroVirol."},{"key":"10.1016\/j.brainres.2019.146397_b0630","doi-asserted-by":"crossref","first-page":"1437","DOI":"10.1097\/QAD.0b013e32833a6114","article-title":"Resveratrol protects against protease inhibitor-induced reactive oxygen species production, reticulum stress and lipid raft perturbation","volume":"24","author":"Touzet","year":"2010","journal-title":"AIDS"},{"key":"10.1016\/j.brainres.2019.146397_b0635","doi-asserted-by":"crossref","first-page":"1729","DOI":"10.1016\/j.freeradbiomed.2008.09.023","article-title":"Severe oxidative damage in multiple sclerosis lesions coincides with enhanced antioxidant enzyme expression","volume":"45","author":"van Horssen","year":"2008","journal-title":"Free Radical Biol. Med."},{"key":"10.1016\/j.brainres.2019.146397_b0640","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1007\/s11481-007-9078-y","article-title":"Spatial learning and memory in HIV-1 transgenic rats","volume":"2","author":"Vigorito","year":"2007","journal-title":"J. Neuroimmune Pharmacol."},{"key":"10.1016\/j.brainres.2019.146397_b0645","doi-asserted-by":"crossref","first-page":"pr2001219","DOI":"10.1203\/00006450-200111000-00003","article-title":"Neurobiology of periventricular leukomalacia in the premature infant","volume":"50","author":"Volpe","year":"2001","journal-title":"Pediatr. Res."},{"key":"10.1016\/j.brainres.2019.146397_b0650","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1016\/j.clineuro.2008.12.006","article-title":"White matter changes in HIV-1 infected brains: a combined gross anatomical and ultrastructural morphometric investigation of the corpus callosum","volume":"111","author":"Wohlschlaeger","year":"2009","journal-title":"Clin. Neurol. Neurosurg."},{"key":"10.1016\/j.brainres.2019.146397_b0660","unstructured":"World Health Organization, 2016. Consolidated guidelines on the use of antiretroviral drugs for treating and preventing HIV infection: recommendations for a public health approach \u2013 2nd ed. https:\/\/apps.who.int\/iris\/bitstream\/handle\/10665\/208825\/9789241549684_eng.pdf?sequence= Accessed [May 31th 2019] [Chapter Recommendation 4.4, What to start: first-line ART]."},{"key":"10.1016\/j.brainres.2019.146397_b0665","doi-asserted-by":"crossref","unstructured":"Wu, X., Sun, L., Zha, W., Studer, E., Gurley, E., Gastroenterology, C.L., 2010. HIV protease inhibitors induce endoplasmic reticulum stress and disrupt barrier integrity in intestinal epithelial cells.","DOI":"10.1053\/j.gastro.2009.08.054"},{"key":"10.1016\/j.brainres.2019.146397_b0670","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1038\/nature07203","article-title":"From endoplasmic-reticulum stress to the inflammatory response","volume":"454","author":"Zhang","year":"2008","journal-title":"Nature"},{"key":"10.1016\/j.brainres.2019.146397_b0675","doi-asserted-by":"crossref","first-page":"25935","DOI":"10.1074\/jbc.R400008200","article-title":"Signaling the unfolded protein response from the endoplasmic reticulum","volume":"279","author":"Zhang","year":"2004","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.brainres.2019.146397_b0680","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1007\/BF03033203","article-title":"HIV-1 infected and immune competent mononuclear phagocytes induce quantitative alterations in neuronal dendritic arbor: Relevance for HIV-1-associated dementia","volume":"3","author":"Zheng","year":"2001","journal-title":"Neurotox. Res."},{"key":"10.1016\/j.brainres.2019.146397_b0685","doi-asserted-by":"crossref","first-page":"G1071","DOI":"10.1152\/ajpgi.00182.2006","article-title":"HIV protease inhibitors activate the unfolded protein response and disrupt lipid metabolism in primary hepatocytes","volume":"291","author":"Zhou","year":"2006","journal-title":"Am. J. Physiol. \u2013 Gastrointestinal Liver Physiol."},{"key":"10.1016\/j.brainres.2019.146397_b0690","doi-asserted-by":"crossref","first-page":"690","DOI":"10.1124\/mol.105.012898","article-title":"HIV protease inhibitors activate the unfolded protein response in macrophages: implication for atherosclerosis and cardiovascular disease","volume":"68","author":"Zhou","year":"2005","journal-title":"Mol. Pharmacol."},{"key":"10.1016\/j.brainres.2019.146397_b0695","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1111\/jnc.14668","article-title":"Effects of HIV-1 Tat on oligodendrocyte viability are mediated by CaMKII\u03b2-GSK3\u03b2 interactions","volume":"149","author":"Zou","year":"2019","journal-title":"J. Neurochem."},{"key":"10.1016\/j.brainres.2019.146397_b0700","doi-asserted-by":"crossref","first-page":"11384","DOI":"10.1523\/JNEUROSCI.4740-14.2015","article-title":"Oligodendrocytes are targets of HIV-1 Tat: NMDA and AMPA receptor-mediated effects on survival and development","volume":"35","author":"Zou","year":"2015","journal-title":"J. Neurosci."},{"key":"10.1016\/j.brainres.2019.146397_b0655","doi-asserted-by":"crossref","first-page":"1291","DOI":"10.1126\/science.278.5341.1291","article-title":"Recovery of replication-competent HIV despite prolonged suppression of plasma viremia","volume":"278","author":"Wong","year":"1997","journal-title":"Science"}],"container-title":["Brain Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006899319304512?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006899319304512?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,13]],"date-time":"2025-09-13T18:03:40Z","timestamp":1757786620000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006899319304512"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,12]]},"references-count":140,"alternative-id":["S0006899319304512"],"URL":"https:\/\/doi.org\/10.1016\/j.brainres.2019.146397","relation":{},"ISSN":["0006-8993"],"issn-type":[{"value":"0006-8993","type":"print"}],"subject":[],"published":{"date-parts":[[2019,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"White matter loss and oligodendrocyte dysfunction in HIV: A consequence of the infection, the antiretroviral therapy or both?","name":"articletitle","label":"Article Title"},{"value":"Brain Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.brainres.2019.146397","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"146397"}}