{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,11]],"date-time":"2026-10-11T02:23:01Z","timestamp":1791685381202,"version":"4.3.4"},"reference-count":67,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100007129","name":"Natural Science Foundation of Shandong Province","doi-asserted-by":"publisher","award":["ZR2018Pc011"],"award-info":[{"award-number":["ZR2018Pc011"]}],"id":[{"id":"10.13039\/501100007129","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007129","name":"Natural Science Foundation of Shandong Province","doi-asserted-by":"publisher","award":["ZR2014HL040"],"award-info":[{"award-number":["ZR2014HL040"]}],"id":[{"id":"10.13039\/501100007129","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007129","name":"Natural Science Foundation of Shandong Province","doi-asserted-by":"publisher","award":["ZR2010HL057"],"award-info":[{"award-number":["ZR2010HL057"]}],"id":[{"id":"10.13039\/501100007129","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008853","name":"Jining Medical University","doi-asserted-by":"publisher","award":["JYP201708"],"award-info":[{"award-number":["JYP201708"]}],"id":[{"id":"10.13039\/501100008853","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81671276"],"award-info":[{"award-number":["81671276"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81501018"],"award-info":[{"award-number":["81501018"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Brain Research"],"published-print":{"date-parts":[[2020,1]]},"DOI":"10.1016\/j.brainres.2019.146493","type":"journal-article","created":{"date-parts":[[2019,10,3]],"date-time":"2019-10-03T11:10:52Z","timestamp":1570101052000},"page":"146493","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":58,"special_numbering":"C","title":["Apelin-36 mediates neuroprotective effects by regulating oxidative stress, autophagy and apoptosis in MPTP-induced Parkinson\u2019s disease model mice"],"prefix":"10.1016","volume":"1726","author":[{"given":"Junge","family":"Zhu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenming","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuehua","family":"Shan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunmei","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huiqing","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ziqi","family":"Shao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shanshan","family":"Dou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunlu","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chuangong","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Baohua","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.brainres.2019.146493_b0005","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1016\/j.tins.2010.09.001","article-title":"Autophagy in neurodegenerative disorders: pathogenic roles and therapeutic implications","volume":"33","author":"Banerjee","year":"2010","journal-title":"Trends Neurosci."},{"key":"10.1016\/j.brainres.2019.146493_b0010","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1007\/s11064-014-1469-x","article-title":"Apelin-13 attenuates traumatic brain injury-induced damage by suppressing autophagy","volume":"40","author":"Bao","year":"2015","journal-title":"Neurochem. Res."},{"key":"10.1016\/j.brainres.2019.146493_b0015","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0001376","article-title":"Nitrated alpha-synuclein immunity accelerates degeneration of nigral dopaminergic neurons","volume":"3","author":"Benner","year":"2008","journal-title":"PLoS One"},{"key":"10.1016\/j.brainres.2019.146493_b0020","doi-asserted-by":"crossref","first-page":"5041","DOI":"10.1021\/ja5131726","article-title":"Elucidating the role of site-specific nitration of alpha-synuclein in the pathogenesis of Parkinson\u2019s disease via protein semisynthesis and mutagenesis","volume":"137","author":"Burai","year":"2015","journal-title":"J Am Chem Soc."},{"key":"10.1016\/j.brainres.2019.146493_b0025","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1007\/s11011-018-0330-3","article-title":"Echinacoside protects against MPTP\/MPP(+)-induced neurotoxicity via regulating autophagy pathway mediated by Sirt1","volume":"34","author":"Chen","year":"2019","journal-title":"Metab. Brain Dis."},{"key":"10.1016\/j.brainres.2019.146493_b0030","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/j.peptides.2012.07.012","article-title":"Neuroprotection of apelin and its signaling pathway","volume":"37","author":"Cheng","year":"2012","journal-title":"Peptides"},{"key":"10.1016\/j.brainres.2019.146493_b0035","doi-asserted-by":"crossref","first-page":"2313","DOI":"10.1007\/s11064-018-2652-2","article-title":"smer28 attenuates dopaminergic toxicity mediated by 6-hydroxydopamine in the rats via modulating oxidative burdens and autophagy-related parameters","volume":"43","author":"Darabi","year":"2018","journal-title":"Neurochem. Res."},{"key":"10.1016\/j.brainres.2019.146493_b0040","doi-asserted-by":"crossref","first-page":"1899","DOI":"10.1007\/s11064-016-1901-5","article-title":"Vanillin attenuated behavioural impairments, neurochemical deficits, oxidative stress and apoptosis against rotenone induced rat model of Parkinson\u2019s disease","volume":"41","author":"Dhanalakshmi","year":"2016","journal-title":"Neurochem. Res."},{"key":"10.1016\/j.brainres.2019.146493_b0045","doi-asserted-by":"crossref","first-page":"1223","DOI":"10.1089\/ars.2005.7.1223","article-title":"Oxidative and antioxidative potential of brain microglial cells","volume":"7","author":"Dringen","year":"2005","journal-title":"Antioxid. Redox Signal."},{"key":"10.1016\/j.brainres.2019.146493_b0050","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1002\/jnr.24092","article-title":"Overexpression of alpha-synuclein in an astrocyte cell line promotes autophagy inhibition and apoptosis","volume":"96","author":"Erustes","year":"2018","journal-title":"J. Neurosci. Res."},{"key":"10.1016\/j.brainres.2019.146493_b0055","doi-asserted-by":"crossref","first-page":"2382563","DOI":"10.1155\/2019\/2382563","article-title":"Vitamin E loaded naringenin nanoemulsion via intranasal delivery for the management of oxidative stress in a 6-OHDA Parkinson\u2019s disease model","volume":"2019","author":"Gaba","year":"2019","journal-title":"Biomed. Res. Int."},{"key":"10.1016\/j.brainres.2019.146493_b0060","doi-asserted-by":"crossref","first-page":"6757","DOI":"10.2147\/IJN.S93918","article-title":"Recent trends in the development of nanophytobioactive compounds and delivery systems for their possible role in reducing oxidative stress in Parkinson's disease models","volume":"10","author":"Ganesan","year":"2015","journal-title":"Int. J. Nanomed."},{"key":"10.1016\/j.brainres.2019.146493_b0065","doi-asserted-by":"crossref","first-page":"7687","DOI":"10.1523\/JNEUROSCI.0143-07.2008","article-title":"Neuroinflammation and oxidation\/nitration of alpha-synuclein linked to dopaminergic neurodegeneration","volume":"28","author":"Gao","year":"2008","journal-title":"J. Neurosci."},{"key":"10.1016\/j.brainres.2019.146493_b0070","doi-asserted-by":"crossref","first-page":"6437","DOI":"10.1523\/JNEUROSCI.1122-04.2004","article-title":"Overexpression of glial cell line-derived neurotrophic factor using a lentiviral vector induces time- and dose-dependent downregulation of tyrosine hydroxylase in the intact nigrostriatal dopamine system","volume":"24","author":"Georgievska","year":"2004","journal-title":"J. Neurosci."},{"key":"10.1016\/j.brainres.2019.146493_b0075","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1002\/path.2697","article-title":"Autophagy: cellular and molecular mechanisms","volume":"221","author":"Glick","year":"2010","journal-title":"J. Pathol."},{"key":"10.1016\/j.brainres.2019.146493_b0080","doi-asserted-by":"crossref","first-page":"492","DOI":"10.1038\/35081564","article-title":"Alpha-synuclein and neurodegenerative diseases","volume":"2","author":"Goedert","year":"2001","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.brainres.2019.146493_b0085","first-page":"1817","article-title":"Damage to dopaminergic neurons by oxidative stress in Parkinson\u2019s disease (review)","volume":"41","author":"Guo","year":"2018","journal-title":"Int. J. Mol. Med."},{"key":"10.1016\/j.brainres.2019.146493_b0090","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.npep.2018.01.001","article-title":"Apelin-13 ameliorates cognitive impairments in 6-hydroxydopamine-induced substantia nigra lesion in rats","volume":"68","author":"Haghparast","year":"2018","journal-title":"Neuropeptides"},{"key":"10.1016\/j.brainres.2019.146493_b0095","doi-asserted-by":"crossref","first-page":"133","DOI":"10.5114\/fn.2018.76618","article-title":"Hydroxysafflor yellow A promotes alpha-synuclein clearance via regulating autophagy in rotenone-induced Parkinson\u2019s disease mice","volume":"56","author":"Han","year":"2018","journal-title":"Folia Neuropathol."},{"key":"10.1016\/j.brainres.2019.146493_b0100","doi-asserted-by":"crossref","first-page":"21061","DOI":"10.1074\/jbc.M908417199","article-title":"Molecular and functional characteristics of APJ. Tissue distribution of mRNA and interaction with the endogenous ligand apelin","volume":"275","author":"Hosoya","year":"2000","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.brainres.2019.146493_b0105","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/S0306-4522(01)00562-0","article-title":"Involvement of inducible nitric oxide synthase in inflammation-induced dopaminergic neurodegeneration","volume":"110","author":"Iravani","year":"2002","journal-title":"Neuroscience"},{"issue":"Suppl.","key":"10.1016\/j.brainres.2019.146493_b0110","doi-asserted-by":"crossref","first-page":"S82","DOI":"10.1002\/ana.410320714","article-title":"Oxidative stress as a cause of nigral cell death in Parkinson\u2019s disease and incidental Lewy body disease. The Royal Kings and Queens Parkinson\u2019s Disease Research Group","volume":"32","author":"Jenner","year":"1992","journal-title":"Ann. Neurol."},{"issue":"Suppl. 3","key":"10.1016\/j.brainres.2019.146493_b0115","doi-asserted-by":"crossref","first-page":"S26","DOI":"10.1002\/ana.10483","article-title":"Oxidative stress in Parkinson\u2019s disease","volume":"53","author":"Jenner","year":"2003","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.brainres.2019.146493_b0120","first-page":"1732","article-title":"Apelin13 attenuates ER stress associated apoptosis induced by MPP+ in SHSY5Y cells","volume":"42","author":"Jiang","year":"2018","journal-title":"Int. J. Mol. Med."},{"key":"10.1016\/j.brainres.2019.146493_b0125","doi-asserted-by":"crossref","first-page":"896","DOI":"10.1016\/S0140-6736(14)61393-3","article-title":"Parkinson\u2019s disease","volume":"386","author":"Kalia","year":"2015","journal-title":"Lancet"},{"key":"10.1016\/j.brainres.2019.146493_b0130","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1038\/nrneurol.2015.249","article-title":"Parkinson disease in 2015: evolving basic, pathological and clinical concepts in PD","volume":"12","author":"Kalia","year":"2016","journal-title":"Nat. Rev. Neurol."},{"key":"10.1016\/j.brainres.2019.146493_b0135","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1016\/S0167-4889(00)00143-9","article-title":"Molecular properties of apelin: tissue distribution and receptor binding","volume":"1538","author":"Kawamata","year":"2001","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.brainres.2019.146493_b0140","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1016\/j.pharmthera.2005.04.001","article-title":"Emerging roles of apelin in biology and medicine","volume":"107","author":"Kleinz","year":"2005","journal-title":"Pharmacol. Ther."},{"key":"10.1016\/j.brainres.2019.146493_b0145","doi-asserted-by":"crossref","first-page":"8447","DOI":"10.1523\/JNEUROSCI.21-21-08447.2001","article-title":"Microglial activation and dopaminergic cell injury: an in vitro model relevant to Parkinson\u2019s disease","volume":"21","author":"Le","year":"2001","journal-title":"J. Neurosci."},{"key":"10.1016\/j.brainres.2019.146493_b0150","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1111\/cns.12555","article-title":"7,8-Dihydroxyflavone ameliorates motor deficits via suppressing alpha-synuclein expression and oxidative stress in the MPTP-induced mouse model of Parkinson\u2019s disease","volume":"22","author":"Li","year":"2016","journal-title":"CNS Neurosci. Ther."},{"key":"10.1016\/j.brainres.2019.146493_b0155","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/j.neuro.2017.09.015","article-title":"Rifampicin inhibits rotenone-induced microglial inflammation via enhancement of autophagy","volume":"63","author":"Liang","year":"2017","journal-title":"Neurotoxicology"},{"key":"10.1016\/j.brainres.2019.146493_b0160","doi-asserted-by":"crossref","first-page":"1403","DOI":"10.1038\/70978","article-title":"Inducible nitric oxide synthase stimulates dopaminergic neurodegeneration in the MPTP model of Parkinson disease","volume":"5","author":"Liberatore","year":"1999","journal-title":"Nat. Med."},{"key":"10.1016\/j.brainres.2019.146493_b0165","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1093\/jmcb\/mjr011","article-title":"A novel molecular mechanism for nitrated {alpha}-synuclein-induced cell death","volume":"3","author":"Liu","year":"2011","journal-title":"J. Mol. Cell Biol."},{"key":"10.1016\/j.brainres.2019.146493_b0170","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1016\/j.neulet.2017.08.044","article-title":"Mitochondrial calcium imbalance in Parkinson\u2019s disease","volume":"663","author":"Ludtmann","year":"2018","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.brainres.2019.146493_b0175","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1042\/BJ20130418","article-title":"Synthetic retinoid Am 80 up-regulates apelin expression by promoting interaction of RARalpha with KLF5 and Sp1 in vascular smooth muscle cells","volume":"456","author":"Lv","year":"2013","journal-title":"Biochem. J."},{"key":"10.1016\/j.brainres.2019.146493_b0180","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1016\/j.freeradbiomed.2016.07.002","article-title":"Intracellular labile iron determines H2O2-induced apoptotic signaling via sustained activation of ASK1\/JNK-p38 axis","volume":"97","author":"Mantzaris","year":"2016","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.brainres.2019.146493_b0185","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/S0167-4781(00)00072-5","article-title":"Distribution of mRNA encoding B78\/apj, the rat homologue of the human APJ receptor, and its endogenous ligand apelin in brain and peripheral tissues","volume":"1492","author":"O'Carroll","year":"2000","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.brainres.2019.146493_b0190","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1016\/0003-2697(79)90738-3","article-title":"Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction","volume":"95","author":"Ohkawa","year":"1979","journal-title":"Anal. Biochem."},{"key":"10.1016\/j.brainres.2019.146493_b0195","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1146\/annurev.neuro.22.1.123","article-title":"Etiology and pathogenesis of Parkinson\u2019s disease","volume":"22","author":"Olanow","year":"1999","journal-title":"Annu. Rev. Neurosci."},{"key":"10.1016\/j.brainres.2019.146493_b0200","doi-asserted-by":"crossref","first-page":"1969","DOI":"10.1093\/brain\/awm318","article-title":"The role of autophagy-lysosome pathway in neurodegeneration associated with Parkinson\u2019s disease","volume":"131","author":"Pan","year":"2008","journal-title":"Brain"},{"key":"10.1016\/j.brainres.2019.146493_b0205","doi-asserted-by":"crossref","first-page":"17013","DOI":"10.1038\/nrdp.2017.13","article-title":"Parkinson disease","volume":"3","author":"Poewe","year":"2017","journal-title":"Nat. Rev. Dis. Primers"},{"key":"10.1016\/j.brainres.2019.146493_b0210","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1089\/rej.2017.1951","article-title":"Protective effect of neuropeptide apelin-13 on 6-hydroxydopamine-induced neurotoxicity in SH-SY5Y dopaminergic cells: involvement of its antioxidant and antiapoptotic properties","volume":"21","author":"Pouresmaeili-Babaki","year":"2018","journal-title":"Rejuvenation Res."},{"key":"10.1016\/j.brainres.2019.146493_b0215","doi-asserted-by":"crossref","first-page":"1085","DOI":"10.1046\/j.1471-4159.2001.00320.x","article-title":"Physiological role of a novel neuropeptide, apelin, and its receptor in the rat brain","volume":"77","author":"Reaux","year":"2001","journal-title":"J. Neurochem."},{"key":"10.1016\/j.brainres.2019.146493_b0220","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1007\/978-3-7091-6360-3_6","article-title":"Parkinson\u2019s disease\u2013a multifactorial neurodegenerative disorder","volume":"56","author":"Riess","year":"1999","journal-title":"J. Neural. Transm. Suppl."},{"key":"10.1016\/j.brainres.2019.146493_b0225","doi-asserted-by":"crossref","first-page":"1657","DOI":"10.1016\/S0006-2952(96)00452-2","article-title":"Mitochondrial respiratory enzyme function and superoxide dismutase activity following brain glutathione depletion in the rat","volume":"52","author":"Seaton","year":"1996","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.brainres.2019.146493_b0230","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1146\/annurev-pathol-011110-130242","article-title":"Parkinson\u2019s disease: genetics and pathogenesis","volume":"6","author":"Shulman","year":"2011","journal-title":"Annu. Rev Pathol."},{"key":"10.1016\/j.brainres.2019.146493_b0235","doi-asserted-by":"crossref","first-page":"13038","DOI":"10.1523\/JNEUROSCI.4407-08.2008","article-title":"Hsp27 protects against ischemic brain injury via attenuation of a novel stress-response cascade upstream of mitochondrial cell death signaling","volume":"28","author":"Stetler","year":"2008","journal-title":"J. Neurosci."},{"key":"10.1016\/j.brainres.2019.146493_b0240","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/j.neulet.2012.06.070","article-title":"A model of nitric oxide induced alpha-synuclein misfolding in Parkinson\u2019s disease","volume":"523","author":"Stone","year":"2012","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.brainres.2019.146493_b0245","doi-asserted-by":"crossref","first-page":"534","DOI":"10.1080\/00207454.2018.1545772","article-title":"Neuroprotective effect of naringenin against MPTP-induced oxidative stress","volume":"129","author":"Sugumar","year":"2019","journal-title":"Int. J. Neurosci."},{"key":"10.1016\/j.brainres.2019.146493_b0250","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1006\/bbrc.1998.9489","article-title":"Isolation and characterization of a novel endogenous peptide ligand for the human APJ receptor","volume":"251","author":"Tatemoto","year":"1998","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.brainres.2019.146493_b0255","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1093\/embo-reports\/kve046","article-title":"ASK1 is required for sustained activations of JNK\/p38 MAP kinases and apoptosis","volume":"2","author":"Tobiume","year":"2001","journal-title":"EMBO Rep."},{"key":"10.1016\/j.brainres.2019.146493_b0260","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1083\/jcb.201606020","article-title":"GSK3B-mediated phosphorylation of MCL1 regulates axonal autophagy to promote Wallerian degeneration","volume":"216","author":"Wakatsuki","year":"2017","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.brainres.2019.146493_b0265","doi-asserted-by":"crossref","first-page":"34479","DOI":"10.1074\/jbc.M705426200","article-title":"Leptin protects against 6-hydroxydopamine-induced dopaminergic cell death via mitogen-activated protein kinase signaling","volume":"282","author":"Weng","year":"2007","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.brainres.2019.146493_b0270","doi-asserted-by":"crossref","first-page":"1023","DOI":"10.1083\/jcb.201003122","article-title":"alpha-Synuclein impairs macroautophagy: implications for Parkinson\u2019s disease","volume":"190","author":"Winslow","year":"2010","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.brainres.2019.146493_b0275","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1002\/mds.26477","article-title":"Autophagy and alpha-synuclein: relevance to Parkinson\u2019s disease and related synucleopathies","volume":"31","author":"Xilouri","year":"2016","journal-title":"Mov. Disord."},{"key":"10.1016\/j.brainres.2019.146493_b0280","doi-asserted-by":"crossref","first-page":"1914","DOI":"10.1007\/s11064-018-2609-5","article-title":"Glycyrrhizic acid alleviates 6-hydroxydopamine and corticosterone-induced neurotoxicity in SH-SY5Y cells through modulating autophagy","volume":"43","author":"Yang","year":"2018","journal-title":"Neurochem. Res."},{"key":"10.1016\/j.brainres.2019.146493_b0285","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/j.toxlet.2009.08.024","article-title":"Paraquat activates the IRE1\/ASK1\/JNK cascade associated with apoptosis in human neuroblastoma SH-SY5Y cells","volume":"191","author":"Yang","year":"2009","journal-title":"Toxicol. Lett."},{"key":"10.1016\/j.brainres.2019.146493_b0290","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.peptides.2014.11.001","article-title":"The protective effect of apelin on ischemia\/reperfusion injury","volume":"63","author":"Yang","year":"2015","journal-title":"Peptides"},{"key":"10.1016\/j.brainres.2019.146493_b0295","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1016\/j.cca.2016.04.001","article-title":"Apelin\/APJ system and cancer","volume":"457","author":"Yang","year":"2016","journal-title":"Clin. Chim. Acta"},{"key":"10.1016\/j.brainres.2019.146493_b0300","doi-asserted-by":"crossref","first-page":"8648","DOI":"10.1096\/fj.201900363R","article-title":"MicroRNA-124 regulates the expression of p62\/p38 and promotes autophagy in the inflammatory pathogenesis of Parkinson\u2019s disease","volume":"33","author":"Yao","year":"2019","journal-title":"FASEB J."},{"key":"10.1016\/j.brainres.2019.146493_b0305","doi-asserted-by":"crossref","first-page":"12178","DOI":"10.1038\/s41598-017-12379-3","article-title":"CIB1 protects against MPTP-induced neurotoxicity through inhibiting ASK1","volume":"7","author":"Yoon","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.brainres.2019.146493_b0310","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1016\/j.biopha.2008.01.017","article-title":"Glutathione and Parkinson's disease: is this the elephant in the room?","volume":"62","author":"Zeevalk","year":"2008","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.brainres.2019.146493_b0315","doi-asserted-by":"crossref","first-page":"273","DOI":"10.14336\/AD.2017.0517","article-title":"SIRT3 protects rotenone-induced injury in SH-SY5Y cells by promoting autophagy through the LKB1-AMPK-mTOR pathway","volume":"9","author":"Zhang","year":"2018","journal-title":"Aging Dis."},{"key":"10.1016\/j.brainres.2019.146493_b0320","doi-asserted-by":"crossref","DOI":"10.1007\/s12031-019-01349-1","article-title":"MicroRNA-326 inhibits apoptosis and promotes proliferation of dopaminergic neurons in Parkinson\u2019s disease through suppression of KLK7-mediated MAPK signaling pathway","author":"Zhang","year":"2019","journal-title":"J. Mol. Neurosci."},{"key":"10.1016\/j.brainres.2019.146493_b0325","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.lfs.2019.03.047","article-title":"Apelin-36 exerts the cytoprotective effect against MPP(+)-induced cytotoxicity in SH-SY5Y cells through PI3K\/Akt\/mTOR autophagy pathway","volume":"224","author":"Zhu","year":"2019","journal-title":"Life Sci."},{"key":"10.1016\/j.brainres.2019.146493_b0330","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/j.brainres.2019.03.027","article-title":"Apelin-13 protects dopaminergic neurons in MPTP-induced Parkinson's disease model mice through inhibiting endoplasmic reticulum stress and promoting autophagy","volume":"1715","author":"Zhu","year":"2019","journal-title":"Brain Res."},{"key":"10.1016\/j.brainres.2019.146493_b0335","doi-asserted-by":"crossref","DOI":"10.1016\/j.brainres.2019.146334","article-title":"Apelin-36 mitigates MPTP\/MPP(+)-induced neurotoxicity: involvement of alpha-synuclein and endoplasmic reticulum stress","author":"Zhu","year":"2019","journal-title":"Brain Res."}],"container-title":["Brain Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006899319305475?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006899319305475?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T15:23:51Z","timestamp":1777389831000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006899319305475"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,1]]},"references-count":67,"alternative-id":["S0006899319305475"],"URL":"https:\/\/doi.org\/10.1016\/j.brainres.2019.146493","relation":{},"ISSN":["0006-8993"],"issn-type":[{"value":"0006-8993","type":"print"}],"subject":[],"published":{"date-parts":[[2020,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Apelin-36 mediates neuroprotective effects by regulating oxidative stress, autophagy and apoptosis in MPTP-induced Parkinson\u2019s disease model mice","name":"articletitle","label":"Article Title"},{"value":"Brain Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.brainres.2019.146493","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"146493"}}