{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,27]],"date-time":"2026-06-27T16:41:44Z","timestamp":1782578504604,"version":"3.54.5"},"reference-count":40,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100001700","name":"Ministry of Education, Culture, Sports, Science and Technology","doi-asserted-by":"publisher","award":["16K20080"],"award-info":[{"award-number":["16K20080"]}],"id":[{"id":"10.13039\/501100001700","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001700","name":"Ministry of Education, Culture, Sports, Science and Technology","doi-asserted-by":"publisher","award":["26893032"],"award-info":[{"award-number":["26893032"]}],"id":[{"id":"10.13039\/501100001700","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001700","name":"Ministry of Education, Culture, Sports, Science and Technology","doi-asserted-by":"publisher","award":["30761100"],"award-info":[{"award-number":["30761100"]}],"id":[{"id":"10.13039\/501100001700","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Brain Research"],"published-print":{"date-parts":[[2020,1]]},"DOI":"10.1016\/j.brainres.2019.146568","type":"journal-article","created":{"date-parts":[[2019,11,27]],"date-time":"2019-11-27T11:10:15Z","timestamp":1574853015000},"page":"146568","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":11,"special_numbering":"C","title":["Loss of endogenous analgesia leads to delayed recovery from incisional pain in a rat model of chronic neuropathic pain"],"prefix":"10.1016","volume":"1727","author":[{"given":"Jo","family":"Ohta","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5796-4308","authenticated-orcid":false,"given":"Takashi","family":"Suto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daiki","family":"Kato","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tadanao","family":"Hiroki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hideaki","family":"Obata","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shigeru","family":"Saito","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.brainres.2019.146568_b0005","article-title":"Local anaesthetics and regional anaesthesia for preventing chronic pain after surgery","volume":"2012","author":"Andreae","year":"2012","journal-title":"Cochrane Database of Syst. Rev."},{"key":"10.1016\/j.brainres.2019.146568_b0010","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1016\/j.pain.2009.08.003","article-title":"Perisurgical amitriptyline produces a preventive effect on afferent hypersensitivity following spared nerve injury","volume":"146","author":"Arsenault","year":"2009","journal-title":"Pain"},{"key":"10.1016\/j.brainres.2019.146568_b0015","doi-asserted-by":"crossref","first-page":"S33","DOI":"10.1016\/j.pain.2010.11.005","article-title":"Pathophysiology of postoperative pain","volume":"152","author":"Brennan","year":"2011","journal-title":"Pain"},{"key":"10.1016\/j.brainres.2019.146568_b0020","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/0165-0270(94)90144-9","article-title":"Quantitative assessment of tactile allodynia in the rat paw","volume":"53","author":"Chaplan","year":"1994","journal-title":"J. Neurosci. Methods"},{"key":"10.1016\/j.brainres.2019.146568_b0025","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/j.jpain.2010.08.005","article-title":"Improving individual measurement of postoperative pain: The pain trajectory","volume":"12","author":"Chapman","year":"2011","journal-title":"J. Pain"},{"key":"10.1016\/j.brainres.2019.146568_b0030","doi-asserted-by":"crossref","first-page":"13699","DOI":"10.1523\/JNEUROSCI.2867-10.2010","article-title":"Attenuation of activity in an endogenous analgesia circuit by ongoing pain in the rat","volume":"30","author":"Ferrari","year":"2010","journal-title":"J. Neurosci."},{"key":"10.1016\/j.brainres.2019.146568_b0035","doi-asserted-by":"crossref","first-page":"7175","DOI":"10.1523\/JNEUROSCI.19-16-07175.1999","article-title":"Pain-induced analgesia mediated by mesolimbic reward circuits","volume":"19","author":"Gear","year":"1999","journal-title":"J. Neurosci."},{"key":"10.1016\/j.brainres.2019.146568_b0040","doi-asserted-by":"crossref","first-page":"1054","DOI":"10.1016\/j.ejpain.2008.11.020","article-title":"Preoperative pain as a risk factor for chronic post-surgical pain - Six month follow-up after radical prostatectomy","volume":"13","author":"Gerbershagen","year":"2009","journal-title":"Eur. J. Pain"},{"key":"10.1016\/j.brainres.2019.146568_b0045","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1097\/ALN.0b013e3181de6d2c","article-title":"Spinal alpha 2-adrenoceptor-mediated analgesia in neuropathic pain reflects brain-derived nerve growth factor and changes in spinal cholinergic neuronal function","volume":"113","author":"Hayashida","year":"2010","journal-title":"Anesthesiology"},{"key":"10.1016\/j.brainres.2019.146568_b0050","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.brainres.2015.12.057","article-title":"Amitriptyline induces brain-derived neurotrophic factor (BDNF) mRNA expression through ERK-dependent modulation of multiple BDNF mRNA variants in primary cultured rat cortical astrocytes and microglia","volume":"1634","author":"Hisaoka-Nakashima","year":"2016","journal-title":"Brain Res."},{"key":"10.1016\/j.brainres.2019.146568_b0055","doi-asserted-by":"crossref","first-page":"1680","DOI":"10.1016\/j.pain.2013.05.010","article-title":"Endogenous analgesic action of the pontospinal noradrenergic system spatially restricts and temporally delays the progression of neuropathic pain following tibial nerve injury","volume":"154","author":"Hughes","year":"2013","journal-title":"Pain"},{"key":"10.1016\/j.brainres.2019.146568_b0060","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1213\/ANE.0000000000002380","article-title":"Repeated administration of duloxetine suppresses neuropathic pain by accumulating effects of noradrenaline in the spinal cord","volume":"126","author":"Ito","year":"2018","journal-title":"Anesth. Analg."},{"key":"10.1016\/j.brainres.2019.146568_b0065","doi-asserted-by":"crossref","first-page":"578","DOI":"10.1213\/ANE.0000000000003592","article-title":"Spinal activation of tropomyosin receptor kinase-B recovers the impaired endogenous analgesia in neuropathic pain rats","volume":"129","author":"Kato","year":"2018","journal-title":"Anesth. Analg."},{"key":"10.1016\/j.brainres.2019.146568_b0070","doi-asserted-by":"crossref","first-page":"1618","DOI":"10.1016\/S0140-6736(06)68700-X","article-title":"Persistent postsurgical pain: risk factors and prevention","volume":"367","author":"Kehlet","year":"2006","journal-title":"The Lancet"},{"key":"10.1016\/j.brainres.2019.146568_b0075","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1016\/0304-3959(92)90041-9","article-title":"An experimental model for peripheral neuropathy produced by segmental spinal nerve ligation in the rat","volume":"50","author":"Kim","year":"1992","journal-title":"Pain"},{"key":"10.1016\/j.brainres.2019.146568_b0080","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/j.neulet.2012.08.008","article-title":"Dexmedetomidine decreases hyperalgesia in neuropathic pain by increasing acetylcholine in the spinal cord","volume":"529","author":"Kimura","year":"2012","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.brainres.2019.146568_b0085","doi-asserted-by":"crossref","first-page":"899","DOI":"10.1097\/ALN.0000000000000796","article-title":"Impaired pain-evoked analgesia after nerve injury in rats reflects altered glutamate regulation in the locus coeruleus","volume":"123","author":"Kimura","year":"2015","journal-title":"Anesthesiology"},{"key":"10.1016\/j.brainres.2019.146568_b0090","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1111\/j.1365-2222.1997.115-az0111.x","article-title":"Postoperative analgesic effect of inthrathecal neostigmine and its influence on spinal anaesthesia","volume":"52","author":"Klamt","year":"1997","journal-title":"Anaesthesia"},{"key":"10.1016\/j.brainres.2019.146568_b0095","doi-asserted-by":"crossref","first-page":"64","DOI":"10.2106\/JBJS.18.00347","article-title":"Duloxetine reduces pain and improves quality of recovery following total knee arthroplasty in centrally sensitized patients","volume":"101","author":"Koh","year":"2019","journal-title":"J. Bone Joint Surg. Am."},{"key":"10.1016\/j.brainres.2019.146568_b0100","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1097\/00000542-200510000-00020","article-title":"Intraoperative epidural analgesia combined with ketamine provides effective preventive analgesia in patients undergoing major digestive surgery","volume":"103","author":"Lavand\u2019homme","year":"2005","journal-title":"Anesthesiology"},{"key":"10.1016\/j.brainres.2019.146568_b0105","doi-asserted-by":"crossref","first-page":"1409","DOI":"10.1007\/s11999-013-3389-5","article-title":"Pain trajectories identify patients at risk of persistent pain after knee arthroplasty","volume":"472","author":"Lavand\u2019homme","year":"2014","journal-title":"Clin. Orthop. Relat. Res."},{"key":"10.1016\/j.brainres.2019.146568_b0110","doi-asserted-by":"crossref","first-page":"936","DOI":"10.1016\/j.jpain.2012.07.005","article-title":"Conditioned pain modulation in populations with chronic pain: A systematic review and meta-analysis","volume":"13","author":"Lewis","year":"2012","journal-title":"J. Pain"},{"key":"10.1016\/j.brainres.2019.146568_b0115","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1213\/ANE.0000000000001301","article-title":"Amitriptyline, but not pregabalin, reverses the attenuation of noxious stimulus-induced analgesia after nerve injury in rats","volume":"123","author":"Matsuoka","year":"2016","journal-title":"Anesth. Analg."},{"key":"10.1016\/j.brainres.2019.146568_b0120","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.neuroscience.2014.10.049","article-title":"Effect of pain chronification and chronic pain on an endogenous pain modulation circuit in rats","volume":"286","author":"Miranda","year":"2015","journal-title":"Neuroscience"},{"key":"10.1016\/j.brainres.2019.146568_b0125","doi-asserted-by":"crossref","first-page":"895","DOI":"10.1097\/ALN.0000000000000593","article-title":"Individual differences in acute pain-induced endogenous analgesia predict time to resolution of postoperative pain in the rat","volume":"122","author":"Peters","year":"2015","journal-title":"Anesthesiology"},{"key":"10.1016\/j.brainres.2019.146568_b0130","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.bpa.2006.11.003","article-title":"Postoperative pain-clinical implications of basic research","volume":"21","author":"Pogatzki-Zahn","year":"2007","journal-title":"Best Practice Res. Clin. Anaesthesiol."},{"key":"10.1016\/j.brainres.2019.146568_b0135","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1152\/jn.00208.2001","article-title":"Characterization of Adelta- and C-fibers innervating the plantar rat hindpaw one day after an incision","volume":"87","author":"Pogatzki","year":"2002","journal-title":"J. Neurophysiol."},{"key":"10.1016\/j.brainres.2019.146568_b0140","doi-asserted-by":"crossref","first-page":"1704","DOI":"10.1097\/j.pain.0000000000000573","article-title":"Pain facilitation and pain inhibition during conditioned pain modulation in fibromyalgia and in healthy controls","volume":"157","author":"Potvin","year":"2016","journal-title":"Pain"},{"key":"10.1016\/j.brainres.2019.146568_b0145","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1016\/j.brainres.2004.05.085","article-title":"Antinociceptive effects of bethanechol or dimethylphenylpiperazinium in models of phasic or incisional pain in rats","volume":"1018","author":"Prado","year":"2004","journal-title":"Brain Res."},{"key":"10.1016\/j.brainres.2019.146568_b0150","first-page":"409","article-title":"A method for measurement of analgesic activity on inflamed tissue","volume":"111","author":"Randall","year":"1957","journal-title":"Arch. Int. Pharmacodyn. Ther."},{"key":"10.1016\/j.brainres.2019.146568_b0155","doi-asserted-by":"crossref","first-page":"590","DOI":"10.1097\/ALN.0000000000002238","article-title":"Persistent postsurgical pain: pathophysiology and preventative pharmacologic considerations","volume":"129","author":"Richeb\u00e9","year":"2018","journal-title":"Anesthesiology"},{"key":"10.1016\/j.brainres.2019.146568_b0160","doi-asserted-by":"crossref","first-page":"608","DOI":"10.1053\/j.jvca.2009.10.006","article-title":"Different anesthetic techniques associated with different incidences of chronic post-thoracotomy pain: Low-dose remifentanil plus presurgical epidural analgesia is preferable to high-dose remifentanil with postsurgical epidural analgesia","volume":"24","author":"Salengros","year":"2010","journal-title":"J. Cardiothorac. Vasc. Anesth."},{"key":"10.1016\/j.brainres.2019.146568_b0165","doi-asserted-by":"crossref","first-page":"1215","DOI":"10.1097\/ALN.0b013e3182a9a896","article-title":"Perioperative gabapentinoids","volume":"119","author":"Schmidt","year":"2013","journal-title":"Anesthesiology"},{"key":"10.1016\/j.brainres.2019.146568_b0170","doi-asserted-by":"crossref","first-page":"600","DOI":"10.1016\/j.jpain.2018.11.008","article-title":"Tropomyosin receptor kinase B receptor activation in the locus coeruleus restores impairment of endogenous analgesia at a late stage following nerve injury in rats","volume":"20","author":"Suto","year":"2019","journal-title":"J. Pain"},{"key":"10.1016\/j.brainres.2019.146568_b0175","first-page":"1","article-title":"Evidence of impaired pain modulation in adolescents with idiopathic scoliosis and chronic back pain","volume":"000","author":"Teles","year":"2018","journal-title":"Spine J."},{"key":"10.1016\/j.brainres.2019.146568_b0180","doi-asserted-by":"crossref","first-page":"670","DOI":"10.1007\/s12630-012-9712-x","article-title":"Chronic pain, healthcare utilization, and quality of life following gastrointestinal surgery","volume":"59","author":"VanDenKerkhof","year":"2012","journal-title":"Can. J. Anesthesia"},{"key":"10.1016\/j.brainres.2019.146568_b0185","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1097\/ALN.0000000000000307","article-title":"Antidepressant drugs for prevention of acute and chronic postsurgical pain","volume":"121","author":"Wong","year":"2014","journal-title":"Anesthesiology"},{"key":"10.1016\/j.brainres.2019.146568_b0190","doi-asserted-by":"crossref","first-page":"2215","DOI":"10.1016\/S0140-6736(11)60245-6","article-title":"Treatment of acute postoperative pain","volume":"377","author":"Wu","year":"2011","journal-title":"Lancet"},{"key":"10.1016\/j.brainres.2019.146568_b0195","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1097\/ACO.0b013e32833c348b","article-title":"Conditioned pain modulation (the diffuse noxious inhibitory control-like effect): its relevance for acute and chronic pain states","volume":"23","author":"Yarnitsky","year":"2010","journal-title":"Curr. Opin. Anaesthesiol."},{"key":"10.1016\/j.brainres.2019.146568_b0200","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.pain.2007.10.033","article-title":"Prediction of chronic post-operative pain: pre-operative DNIC testing identifies patients at risk","volume":"138","author":"Yarnitsky","year":"2008","journal-title":"Pain"}],"container-title":["Brain Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006899319306225?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006899319306225?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,13]],"date-time":"2025-09-13T18:04:53Z","timestamp":1757786693000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006899319306225"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,1]]},"references-count":40,"alternative-id":["S0006899319306225"],"URL":"https:\/\/doi.org\/10.1016\/j.brainres.2019.146568","relation":{},"ISSN":["0006-8993"],"issn-type":[{"value":"0006-8993","type":"print"}],"subject":[],"published":{"date-parts":[[2020,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Loss of endogenous analgesia leads to delayed recovery from incisional pain in a rat model of chronic neuropathic pain","name":"articletitle","label":"Article Title"},{"value":"Brain Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.brainres.2019.146568","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"146568"}}