{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,21]],"date-time":"2026-06-21T13:46:35Z","timestamp":1782049595167,"version":"3.54.5"},"reference-count":47,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,3,1]],"date-time":"2020-03-01T00:00:00Z","timestamp":1583020800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,3,1]],"date-time":"2020-03-01T00:00:00Z","timestamp":1583020800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Brain Research"],"published-print":{"date-parts":[[2020,3]]},"DOI":"10.1016\/j.brainres.2020.146665","type":"journal-article","created":{"date-parts":[[2020,1,10]],"date-time":"2020-01-10T11:29:02Z","timestamp":1578655742000},"page":"146665","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":21,"special_numbering":"C","title":["Introduction to the Special Issue: \u201cMaking orexin-based therapies for addiction a reality: What are the steps from here?\u201d"],"prefix":"10.1016","volume":"1731","author":[{"given":"Morgan H.","family":"James","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gary","family":"Aston-Jones","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.brainres.2020.146665_b0005","article-title":"Role of medial hypothalamic orexin system in panic, phobia and hypertension","author":"Abreu","year":"2018","journal-title":"Brain Res."},{"key":"10.1016\/j.brainres.2020.146665_b0010","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1002\/cne.10783","article-title":"Overlapping distributions of orexin\/hypocretin- and dopamine-beta-hydroxylase immunoreactive fibers in rat brain regions mediating arousal, motivation, and stress","volume":"464","author":"Baldo","year":"2003","journal-title":"J. Comp. Neurol."},{"key":"10.1016\/j.brainres.2020.146665_b0015","article-title":"Orexin\/hypocretin and dysregulated eating: promotion of foraging behavior","author":"Barson","year":"2018","journal-title":"Brain Res."},{"key":"10.1016\/j.brainres.2020.146665_b0020","doi-asserted-by":"crossref","first-page":"1149","DOI":"10.1111\/ejn.12866","article-title":"Orexin-1 receptor signaling increases motivation for cocaine-associated cues","volume":"41","author":"Bentzley","year":"2015","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.brainres.2020.146665_b0025","article-title":"Hypocretin receptor 1 involvement in cocaine-associated behavior: therapeutic potential and novel mechanistic insights","author":"Brodnik","year":"2018","journal-title":"Brain Res."},{"key":"10.1016\/j.brainres.2020.146665_b0030","doi-asserted-by":"crossref","first-page":"2067","DOI":"10.1017\/S1461145713000333","article-title":"Central orexin (hypocretin) 2 receptor antagonism reduces ethanol self-administration, but not cue-conditioned ethanol-seeking, in ethanol-preferring rats","volume":"16","author":"Brown","year":"2013","journal-title":"Int. J. Neuropsychopharmacol."},{"key":"10.1016\/j.brainres.2020.146665_b0035","article-title":"How orexin signals bias action: hypothalamic and accumbal circuits","author":"Burdakov","year":"2018","journal-title":"Brain Res."},{"key":"10.1016\/j.brainres.2020.146665_b0040","article-title":"Intranasal administration of orexin peptides: mechanisms and therapeutic potential for age-related cognitive dysfunction","author":"Calva","year":"2018","journal-title":"Brain Res."},{"key":"10.1016\/j.brainres.2020.146665_b0045","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1111\/jnc.14279","article-title":"Increased acetylcholine and glutamate efflux in the prefrontal cortex following intranasal orexin-A (hypocretin-1)","volume":"145","author":"Calva","year":"2018","journal-title":"J. Neurochem."},{"key":"10.1016\/j.brainres.2020.146665_b0050","article-title":"A sleeping giant: suvorexant for the treatment of alcohol use disorder?","author":"Campbell","year":"2018","journal-title":"Brain Res."},{"key":"10.1016\/j.brainres.2020.146665_b0055","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1002\/cne.20369","article-title":"Organization of hypocretin\/orexin efferents to locus coeruleus and basal forebrain arousal-related structures","volume":"481","author":"Espana","year":"2005","journal-title":"J. Comp. Neurol."},{"key":"10.1016\/j.brainres.2020.146665_b0060","doi-asserted-by":"crossref","first-page":"1690","DOI":"10.1038\/s41386-019-0420-x","article-title":"The role of orexin-1 receptor signaling in demand for the opioid fentanyl","volume":"44","author":"Fragale","year":"2019","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.brainres.2020.146665_b0065","article-title":"Activation of medial hypothalamic orexin neurons during a Go\/No-Go task","author":"Freeman","year":"2018","journal-title":"Brain Res."},{"key":"10.1016\/j.brainres.2020.146665_b0070","doi-asserted-by":"crossref","first-page":"1580","DOI":"10.1126\/science.2011738","article-title":"Cocaine addiction: psychology and neurophysiology","volume":"251","author":"Gawin","year":"1991","journal-title":"Science"},{"key":"10.1016\/j.brainres.2020.146665_b0075","article-title":"The contribution of orexins to sex differences in the stress response","author":"Grafe","year":"2018","journal-title":"Brain Res."},{"key":"10.1016\/j.brainres.2020.146665_b0080","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1001\/archpsyc.61.8.807","article-title":"Prevalence and co-occurrence of substance use disorders and independent mood and anxiety disorders: results from the National Epidemiologic Survey on Alcohol and Related Conditions","volume":"61","author":"Grant","year":"2004","journal-title":"Arch. Gen. Psychiatry"},{"key":"10.1016\/j.brainres.2020.146665_b0085","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1038\/nature04071","article-title":"A role for lateral hypothalamic orexin neurons in reward seeking","volume":"437","author":"Harris","year":"2005","journal-title":"Nature"},{"key":"10.1016\/j.brainres.2020.146665_b0090","doi-asserted-by":"crossref","first-page":"552","DOI":"10.1016\/j.biopsych.2017.01.010","article-title":"Orexin\/hypocretin, central amygdala, and escalation of cocaine intake","volume":"81","author":"James","year":"2017","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.brainres.2020.146665_b0095","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1007\/7854_2016_56","article-title":"Role of the orexin\/hypocretin system in stress-related psychiatric disorders","volume":"33","author":"James","year":"2017","journal-title":"Curr. Top Behav. Neurosci."},{"key":"10.1016\/j.brainres.2020.146665_bib231","doi-asserted-by":"crossref","DOI":"10.1038\/s41386-020-0619-x","article-title":"Repurposing the dual orexin receptor antagonist suvorexant for the treatment of opioid use disorder: Why sleep on this any longer?","author":"James","year":"2020","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.brainres.2020.146665_b0100","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1007\/7854_2016_57","article-title":"A decade of orexin\/hypocretin and addiction: where are we now?","volume":"33","author":"James","year":"2017","journal-title":"Curr. Top. Behav. Neurosci."},{"key":"10.1016\/j.brainres.2020.146665_b0105","article-title":"Demand elasticity predicts addiction endophenotypes and the therapeutic efficacy of an orexin\/hypocretin-1 receptor antagonist in rats","author":"James","year":"2018","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.brainres.2020.146665_b0110","article-title":"Increased number and activity of a lateral subpopulation of hypothalamic orexin\/hypocretin neurons underlies the expression of an addicted state in rats","author":"James","year":"2018","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.brainres.2020.146665_b0115","doi-asserted-by":"crossref","first-page":"752","DOI":"10.1038\/sj.bjp.0706789","article-title":"The orexin system regulates alcohol-seeking in rats","volume":"148","author":"Lawrence","year":"2006","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.brainres.2020.146665_b0120","article-title":"Cell type- and pathway-specific synaptic regulation of orexin neurocircuitry","author":"Liu","year":"2018","journal-title":"Brain Res."},{"key":"10.1016\/j.brainres.2020.146665_b0125","doi-asserted-by":"crossref","first-page":"1298","DOI":"10.1038\/nn.3810","article-title":"Motivational activation: a unifying hypothesis of orexin\/hypocretin function","volume":"17","author":"Mahler","year":"2014","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.brainres.2020.146665_b0130","doi-asserted-by":"crossref","DOI":"10.1523\/JNEUROSCI.0255-19.2019","article-title":"Orexin-1 receptor signaling in ventral pallidum regulates motivation for the opioid remifentanil","author":"Mohammadkhani","year":"2019","journal-title":"J. Neurosci."},{"key":"10.1016\/j.brainres.2020.146665_b0135","article-title":"Persistent effects of the orexin-1 receptor antagonist SB-334867 on motivation for the fast acting opioid remifentanil","author":"Mohammadkhani","year":"2019","journal-title":"Brain Res."},{"key":"10.1016\/j.brainres.2020.146665_b0140","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.brainres.2016.10.018","article-title":"Orexin\/hypocretin-1 receptor antagonism reduces ethanol self-administration and reinstatement selectively in highly-motivated rats","volume":"1654","author":"Moorman","year":"2017","journal-title":"Brain Res."},{"key":"10.1016\/j.brainres.2020.146665_b0145","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1358\/dot.2016.52.1.2439940","article-title":"Suvorexant: efficacy and safety profile of a dual orexin receptor antagonist in treating insomnia","volume":"52","author":"Owen","year":"2016","journal-title":"Drugs Today (Barc)."},{"key":"10.1016\/j.brainres.2020.146665_b0150","article-title":"The number of lateral hypothalamus orexin\/hypocretin neurons contributes to individual differences in cocaine demand","author":"Pantazis","year":"2019","journal-title":"Addict. Biol."},{"key":"10.1016\/j.brainres.2020.146665_b0155","article-title":"Therapeutics development for addiction: orexin-1 receptor antagonists","author":"Perrey","year":"2018","journal-title":"Brain Res."},{"key":"10.1016\/j.brainres.2020.146665_b0160","doi-asserted-by":"crossref","DOI":"10.1136\/bcr-2017-222037","article-title":"Adverse reaction with suvorexant for insomnia: acute worsening of depression with emergence of suicidal thoughts","volume":"2017","author":"Petrous","year":"2017","journal-title":"BMJ Case Rep."},{"key":"10.1016\/j.brainres.2020.146665_b0165","doi-asserted-by":"crossref","first-page":"1724","DOI":"10.1038\/npp.2013.72","article-title":"A role for hypocretin\/orexin receptor-1 in cue-induced reinstatement of nicotine-seeking behavior","volume":"38","author":"Plaza-Zabala","year":"2013","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.brainres.2020.146665_b0170","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1038\/s41386-018-0292-5","article-title":"NIDA's medication development priorities in response to the Opioid Crisis: ten most wanted","volume":"44","author":"Rasmussen","year":"2019","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.brainres.2020.146665_b0175","doi-asserted-by":"crossref","first-page":"1123","DOI":"10.1038\/npp.2014.293","article-title":"Hypocretin receptor 2 antagonism dose-dependently reduces escalated heroin self-administration in rats","volume":"40","author":"Schmeichel","year":"2015","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.brainres.2020.146665_b0180","article-title":"Cocaine abuse and midbrain circuits: functional anatomy of hypocretin\/orexin transmission and therapeutic prospect","author":"Simmons","year":"2019","journal-title":"Brain Res."},{"key":"10.1016\/j.brainres.2020.146665_b0185","article-title":"Orexin as a modulator of fear-related behavior: hypothalamic control of noradrenaline circuit","author":"Soya","year":"2018","journal-title":"Brain Res."},{"key":"10.1016\/j.brainres.2020.146665_b0190","article-title":"Preliminary examination of the orexin system on relapse-related factors in cocaine use disorder","author":"Suchting","year":"2019","journal-title":"Brain Res."},{"key":"10.1016\/j.brainres.2020.146665_b0195","article-title":"Orexin\/hypocretin receptor modulation of anxiolytic and antidepressive responses during social stress and decision-making: potential for therapy","author":"Summers","year":"2018","journal-title":"Brain Res."},{"key":"10.1016\/j.brainres.2020.146665_b0200","article-title":"Lateral hypothalamic orexin glucose-inhibited neurons may regulate reward-based feeding by modulating glutamate transmission in the ventral tegmental area","author":"Teegala","year":"2018","journal-title":"Brain Res."},{"key":"10.1016\/j.brainres.2020.146665_b0205","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.aao4953","article-title":"Opiates increase the number of hypocretin-producing cells in human and mouse brain and reverse cataplexy in a mouse model of narcolepsy","volume":"10","author":"Thannickal","year":"2018","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.brainres.2020.146665_b0210","doi-asserted-by":"crossref","unstructured":"Wardle, M., Yoon, J., Vujanovic, A., Weaver, M., Lane, S., Schmitz, J., 2016. Behavioral Mechanisms in Addiction, pp. 39\u201366.","DOI":"10.1093\/med\/9780199367894.003.0002"},{"key":"10.1016\/j.brainres.2020.146665_b0215","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.bbr.2013.12.045","article-title":"The effect of intranasal orexin-A (hypocretin-1) on sleep, wakefulness and attention in narcolepsy with cataplexy","volume":"262","author":"Weinhold","year":"2014","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.brainres.2020.146665_b0220","article-title":"The orexin-1 receptor antagonist SB-334867 reduces motivation, but not inhibitory control, in a rat stop signal task","author":"Wiskerke","year":"2019","journal-title":"Brain Res."},{"key":"10.1016\/j.brainres.2020.146665_b0225","doi-asserted-by":"crossref","first-page":"36","DOI":"10.3389\/fnins.2014.00036","article-title":"Orexin antagonists for neuropsychiatric disease: progress and potential pitfalls","volume":"8","author":"Yeoh","year":"2014","journal-title":"Front. Neurosci."},{"key":"10.1016\/j.brainres.2020.146665_b0230","article-title":"The potential role of the orexin reward system in future treatments for opioid drug abuse","author":"Zarrabian","year":"2018","journal-title":"Brain Res."}],"container-title":["Brain Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006899320300214?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006899320300214?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,13]],"date-time":"2025-09-13T18:07:48Z","timestamp":1757786868000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006899320300214"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,3]]},"references-count":47,"alternative-id":["S0006899320300214"],"URL":"https:\/\/doi.org\/10.1016\/j.brainres.2020.146665","relation":{},"ISSN":["0006-8993"],"issn-type":[{"value":"0006-8993","type":"print"}],"subject":[],"published":{"date-parts":[[2020,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Introduction to the Special Issue: \u201cMaking orexin-based therapies for addiction a reality: What are the steps from here?\u201d","name":"articletitle","label":"Article Title"},{"value":"Brain Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.brainres.2020.146665","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"simple-article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"146665"}}