{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,16]],"date-time":"2025-09-16T19:13:09Z","timestamp":1758049989523,"version":"3.44.0"},"reference-count":36,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,6,1]],"date-time":"2020-06-01T00:00:00Z","timestamp":1590969600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,6,1]],"date-time":"2020-06-01T00:00:00Z","timestamp":1590969600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/100011532","name":"American Pediatric Surgical Nurses Association","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100011532","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["NS088479"],"award-info":[{"award-number":["NS088479"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Brain Research"],"published-print":{"date-parts":[[2020,6]]},"DOI":"10.1016\/j.brainres.2020.146699","type":"journal-article","created":{"date-parts":[[2020,2,3]],"date-time":"2020-02-03T11:57:14Z","timestamp":1580731034000},"page":"146699","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"special_numbering":"C","title":["Voltage dependent allosteric modulation of IPSCs by benzodiazepines"],"prefix":"10.1016","volume":"1736","author":[{"given":"Alexander","family":"Baez","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Trevor","family":"Van Brunt","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gabrielle","family":"Moody","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lonnie P.","family":"Wollmuth","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5226-1921","authenticated-orcid":false,"given":"Helen","family":"Hsieh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.brainres.2020.146699_b0005","doi-asserted-by":"crossref","first-page":"12739","DOI":"10.1523\/JNEUROSCI.0040-13.2013","article-title":"Synapse-associated protein 97 regulates the membrane properties of fast-spiking parvalbumin interneurons in the visual cortex","volume":"33","author":"Akgul","year":"2013","journal-title":"J. Neurosci."},{"key":"10.1016\/j.brainres.2020.146699_b0010","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1038\/nrn1703","article-title":"Neurosteroids: endogenous regulators of the GABA(A) receptor","volume":"6","author":"Belelli","year":"2005","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.brainres.2020.146699_b0015","doi-asserted-by":"crossref","DOI":"10.1016\/j.yebeh.2019.106466","article-title":"Intravenous antiepileptic drugs in adults with benzodiazepine-resistant convulsive status epilepticus: a systematic review and network meta-analysis","author":"Brigo","year":"2019","journal-title":"Epilepsy Behav."},{"key":"10.1016\/j.brainres.2020.146699_b0020","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1113\/jphysiol.2014.280263","article-title":"Developmentally regulated neurosteroid synthesis enhances GABAergic neurotransmission in mouse thalamocortical neurones","volume":"593","author":"Brown","year":"2015","journal-title":"J. Physiol."},{"year":"1996","author":"Cooper","series-title":"The Biochemical Basis of Neuropharmacology","key":"10.1016\/j.brainres.2020.146699_b0025"},{"key":"10.1016\/j.brainres.2020.146699_b0030","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1016\/j.jtcvs.2016.03.095","article-title":"Increasing cumulative exposure to volatile anesthetic agents is associated with poorer neurodevelopmental outcomes in children with hypoplastic left heart syndrome","volume":"152","author":"Diaz","year":"2016","journal-title":"J. Thorac Cardiovasc. Surg."},{"key":"10.1016\/j.brainres.2020.146699_b0035","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1111\/jcpt.12787","article-title":"Frequency, risk factors and symptomatology of iatrogenic withdrawal from opioids and benzodiazepines in critically Ill neonates, children and adults: a systematic review of clinical studies","volume":"44","author":"Duceppe","year":"2019","journal-title":"J. Clin. Pharm. Ther."},{"key":"10.1016\/j.brainres.2020.146699_b0040","doi-asserted-by":"crossref","first-page":"548","DOI":"10.1002\/ana.24601","article-title":"Midazolam dose correlates with abnormal hippocampal growth and neurodevelopmental outcome in preterm infants","volume":"79","author":"Duerden","year":"2016","journal-title":"Ann Neurol."},{"key":"10.1016\/j.brainres.2020.146699_b0045","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1203\/PDR.0b013e3181c8eef3","article-title":"Use of analgesic and sedative drugs in the NICU: integrating clinical trials and laboratory data","volume":"67","author":"Durrmeyer","year":"2010","journal-title":"Pediatr Res."},{"key":"10.1016\/j.brainres.2020.146699_b0050","doi-asserted-by":"crossref","first-page":"170","DOI":"10.3389\/fncir.2013.00170","article-title":"Pathophysiological power of improper tonic GABA(A) conductances in mature and immature models","volume":"7","author":"Egawa","year":"2013","journal-title":"Front Neural Circuits."},{"key":"10.1016\/j.brainres.2020.146699_b0055","doi-asserted-by":"crossref","first-page":"1681","DOI":"10.1126\/science.1091032","article-title":"Specific GABAA circuits for visual cortical plasticity","volume":"303","author":"Fagiolini","year":"2004","journal-title":"Science"},{"key":"10.1016\/j.brainres.2020.146699_b0060","doi-asserted-by":"crossref","first-page":"3063","DOI":"10.1152\/jn.00495.2018","article-title":"Input-specific maturation of NMDAR-mediated transmission onto parvalbumin-expressing interneurons in layers 2\/3 of the visual cortex","volume":"120","author":"Ferrer","year":"2018","journal-title":"J. Neurophysiol."},{"key":"10.1016\/j.brainres.2020.146699_b0065","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.brainres.2008.02.017","article-title":"Varying magnitude of GABAergic recurrent inhibition enhancement by different sedative\/anesthetic agents in dorsal and ventral hippocampus","volume":"1207","author":"Georgopoulos","year":"2008","journal-title":"Brain Res."},{"key":"10.1016\/j.brainres.2020.146699_b0070","doi-asserted-by":"crossref","first-page":"3463","DOI":"10.1185\/03007990802561148","article-title":"Core elements of epilepsy diagnosis and management: expert consensus from the Leadership in epilepsy, advocacy, and development (LEAD) faculty","volume":"24","author":"Glauser","year":"2008","journal-title":"Curr. Med. Res Opin."},{"key":"10.1016\/j.brainres.2020.146699_b0075","doi-asserted-by":"crossref","first-page":"873","DOI":"10.1016\/S0028-3908(03)00251-X","article-title":"Phosphorylation influences neurosteroid modulation of synaptic GABAA receptors in rat CA1 and dentate gyrus neurones","volume":"45","author":"Harney","year":"2003","journal-title":"Neuropharmacology"},{"unstructured":"B. Hille Inc, Vol., Sinauer Associates 1992 Sunderland, Massachusetts.","key":"10.1016\/j.brainres.2020.146699_b0080"},{"key":"10.1016\/j.brainres.2020.146699_b0085","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1097\/ALN.0000000000001735","article-title":"Association between exposure of young children to procedures requiring general anesthesia and learning and behavioral outcomes in a population-based birth cohort","volume":"127","author":"Hu","year":"2017","journal-title":"Anesthesiology"},{"key":"10.1016\/j.brainres.2020.146699_b0090","doi-asserted-by":"crossref","first-page":"18595","DOI":"10.1073\/pnas.1204994109","article-title":"Benzodiazepine treatment induces subtype-specific changes in GABA(A) receptor trafficking and decreases synaptic inhibition","volume":"109","author":"Jacob","year":"2012","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.brainres.2020.146699_b0095","doi-asserted-by":"crossref","first-page":"876","DOI":"10.1523\/JNEUROSCI.23-03-00876.2003","article-title":"Early exposure to common anesthetic agents causes widespread neurodegeneration in the developing rat brain and persistent learning deficits","volume":"23","author":"Jevtovic-Todorovic","year":"2003","journal-title":"J. Neurosci."},{"key":"10.1016\/j.brainres.2020.146699_b0100","doi-asserted-by":"crossref","first-page":"8056","DOI":"10.1523\/JNEUROSCI.0348-05.2005","article-title":"Structural determinants of benzodiazepine allosteric regulation of GABA(A) receptor currents","volume":"25","author":"Jones-Davis","year":"2005","journal-title":"J. Neurosci."},{"key":"10.1016\/j.brainres.2020.146699_b0105","doi-asserted-by":"crossref","first-page":"640","DOI":"10.1124\/mol.105.017236","article-title":"Pharmacological properties of GABAA receptors containing gamma1 subunits","volume":"69","author":"Khom","year":"2006","journal-title":"Mol. Pharmacol."},{"key":"10.1016\/j.brainres.2020.146699_b0110","first-page":"S59","article-title":"Developmental pharmacology of benzodiazepines under normal and pathological conditions","volume":"1","author":"McGoldrick","year":"2014","journal-title":"Epileptic Disord. 16 Spec No"},{"issue":"Pt 2","key":"10.1016\/j.brainres.2020.146699_b0115","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1111\/j.1469-7793.1998.377bw.x","article-title":"Voltage-dependent deactivation and desensitization of GABA responses in cultured murine cerebellar granule cells","volume":"506","author":"Mellor","year":"1998","journal-title":"J. Physiol."},{"key":"10.1016\/j.brainres.2020.146699_b0120","first-page":"Cd002052","article-title":"Intravenous midazolam infusion for sedation of infants in the neonatal intensive care unit","volume":"1","author":"Ng","year":"2017","journal-title":"Cochrane Database Syst. Rev."},{"key":"10.1016\/j.brainres.2020.146699_b0125","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1124\/mol.111.074476","article-title":"The apparent voltage dependence of GABAA receptor activation and modulation is inversely related to channel open probability","volume":"81","author":"O'Toole","year":"2012","journal-title":"Mol. Pharmacol."},{"key":"10.1016\/j.brainres.2020.146699_b0130","doi-asserted-by":"crossref","DOI":"10.3791\/2462","article-title":"Organotypic hippocampal slice cultures","author":"Opitz-Araya","year":"2011","journal-title":"J. Vis. Exp."},{"key":"10.1016\/j.brainres.2020.146699_b0135","doi-asserted-by":"crossref","DOI":"10.1155\/2014\/309342","article-title":"Clinical pharmacology of midazolam in neonates and children: effect of disease-a review","volume":"2014","author":"Pacifici","year":"2014","journal-title":"Int. J. Pediatr."},{"key":"10.1016\/j.brainres.2020.146699_b0140","doi-asserted-by":"crossref","first-page":"1619","DOI":"10.1152\/physrev.00007.2017","article-title":"Hippocampal GABAergic Inhibitory Interneurons","volume":"97","author":"Pelkey","year":"2017","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.brainres.2020.146699_b0145","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1038\/16697","article-title":"The K+\/Cl- co-transporter KCC2 renders GABA hyperpolarizing during neuronal maturation","volume":"397","author":"Rivera","year":"1999","journal-title":"Nature"},{"key":"10.1016\/j.brainres.2020.146699_b0150","doi-asserted-by":"crossref","first-page":"1076","DOI":"10.1152\/jn.1993.70.3.1076","article-title":"Developmental study of benzodiazepine effects on monosynaptic GABAA-mediated IPSPs of rat hippocampal neurons","volume":"70","author":"Rovira","year":"1993","journal-title":"J. Neurophysiol."},{"key":"10.1016\/j.brainres.2020.146699_b0155","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1016\/j.tips.2018.03.006","article-title":"The benzodiazepine binding sites of GABAA receptors","volume":"39","author":"Sigel","year":"2018","journal-title":"Trends Pharmacol. Sci."},{"doi-asserted-by":"crossref","unstructured":"Sultan, K.T., Shi, S.H., 2018. Generation of diverse cortical inhibitory interneurons. Wiley Interdiscip Rev Dev Biol. 7.","key":"10.1016\/j.brainres.2020.146699_b0160","DOI":"10.1002\/wdev.306"},{"key":"10.1016\/j.brainres.2020.146699_b0165","doi-asserted-by":"crossref","first-page":"16788","DOI":"10.1523\/JNEUROSCI.4101-10.2010","article-title":"Midazolam inhibits hippocampal long-term potentiation and learning through dual central and peripheral benzodiazepine receptor activation and neurosteroidogenesis","volume":"30","author":"Tokuda","year":"2010","journal-title":"J. Neurosci."},{"key":"10.1016\/j.brainres.2020.146699_b0170","doi-asserted-by":"crossref","first-page":"796","DOI":"10.1097\/01.anes.0000344728.34332.5d","article-title":"Early exposure to anesthesia and learning disabilities in a population-based birth cohort","volume":"110","author":"Wilder","year":"2009","journal-title":"Anesthesiology"},{"key":"10.1016\/j.brainres.2020.146699_b0175","doi-asserted-by":"crossref","first-page":"1040","DOI":"10.1523\/JNEUROSCI.12-03-01040.1992","article-title":"The distribution of 13 GABAA receptor subunit mRNAs in the rat brain. I. Telencephalon, diencephalon, mesencephalon","volume":"12","author":"Wisden","year":"1992","journal-title":"J. Neurosci."},{"key":"10.1016\/j.brainres.2020.146699_b0180","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1097\/ANA.0000000000000541","article-title":"Early developmental exposure to repetitive long duration of midazolam sedation causes behavioral and synaptic alterations in a rodent model of neurodevelopment","volume":"31","author":"Xu","year":"2019","journal-title":"J. Neurosurg. Anesthesiol."}],"container-title":["Brain Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S000689932030055X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S000689932030055X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,13]],"date-time":"2025-09-13T18:09:11Z","timestamp":1757786951000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S000689932030055X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,6]]},"references-count":36,"alternative-id":["S000689932030055X"],"URL":"https:\/\/doi.org\/10.1016\/j.brainres.2020.146699","relation":{},"ISSN":["0006-8993"],"issn-type":[{"type":"print","value":"0006-8993"}],"subject":[],"published":{"date-parts":[[2020,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Voltage dependent allosteric modulation of IPSCs by benzodiazepines","name":"articletitle","label":"Article Title"},{"value":"Brain Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.brainres.2020.146699","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"146699"}}