{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,16]],"date-time":"2025-09-16T19:15:00Z","timestamp":1758050100967,"version":"3.44.0"},"reference-count":93,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,9,1]],"date-time":"2020-09-01T00:00:00Z","timestamp":1598918400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,9,1]],"date-time":"2020-09-01T00:00:00Z","timestamp":1598918400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004586","name":"Funda\u00e7\u00e3o Carlos Chagas Filho de Amparo \u00e0 Pesquisa do Estado do Rio de Janeiro","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004586","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Brain Research"],"published-print":{"date-parts":[[2020,9]]},"DOI":"10.1016\/j.brainres.2020.146906","type":"journal-article","created":{"date-parts":[[2020,5,27]],"date-time":"2020-05-27T11:19:39Z","timestamp":1590578379000},"page":"146906","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["Malnourishment during early lactation disrupts the ontogenetic distribution of the CART and \u03b1-MSH anorexigenic molecules in the arcuate\/paraventricular pathway and lateral hypothalamus in male rats"],"prefix":"10.1016","volume":"1743","author":[{"given":"Michael L.M.","family":"Rocha","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Priscilla P.","family":"Fernandes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Frank","family":"Ten\u00f3rio","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alex C.","family":"Manh\u00e3es","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5868-4447","authenticated-orcid":false,"given":"Penha C.","family":"Barradas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.brainres.2020.146906_b0005","doi-asserted-by":"crossref","unstructured":"Andrews, Z.B., Liu, Z.W, Walllingford, N., Erion, D.M., Borok, E., Friedman, Tsch\u00f6p, M.H., Shanabrough, M., Cline, G., Shulman, G.I., Coppola, A., Gao, X.B., Horvath, T.L., J.M., Diano, S. (2008). UCP2 mediates ghrelin's action on NPY\/AgRP neurons by lowering free radicals. Nature, 454 (7206), 846-851. https:\/\/doi:10.1038\/nature07181.","DOI":"10.1038\/nature07181"},{"issue":"10","key":"10.1016\/j.brainres.2020.146906_b0010","doi-asserted-by":"crossref","first-page":"1549","DOI":"10.1172\/JCI105646","article-title":"The significance of basal insulin levels in the evaluation of the insulin response to glucose in diabetic and nondiabetic subjects","volume":"46","author":"Bagdade","year":"1967","journal-title":"J. Clin. Invest."},{"issue":"11","key":"10.1016\/j.brainres.2020.146906_b0015","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1007\/s00011-003-1207-3","article-title":"Impairment of inflammatory response in adult rats submitted to maternal undernutrition during early lactation: role of insulin and glucocorticoid","volume":"52","author":"Barja-Fidalgo","year":"2003","journal-title":"Inflamm. Res."},{"issue":"8","key":"10.1016\/j.brainres.2020.146906_b0020","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1023\/A:1025388901248","article-title":"The developmental origins of adult disease","volume":"18","author":"Barker","year":"2003","journal-title":"Eur. J. Epidemiol."},{"issue":"3","key":"10.1016\/j.brainres.2020.146906_b0025","doi-asserted-by":"crossref","DOI":"10.1042\/BSR20150007","article-title":"Undernutrition during pregnancy in mice leads to dysfunctional cardiac muscle respiration in adult offspring","volume":"35","author":"Beauchamp","year":"2015","journal-title":"Biosci. Rep."},{"issue":"8","key":"10.1016\/j.brainres.2020.146906_b0030","doi-asserted-by":"crossref","first-page":"1330","DOI":"10.1038\/oby.2006.151","article-title":"The importance of catch-up growth after early malnutrition for the programming of obesity in male rat","volume":"14","author":"Bieswal","year":"2006","journal-title":"Obesity (Silver Spring)"},{"issue":"2","key":"10.1016\/j.brainres.2020.146906_b0035","doi-asserted-by":"crossref","first-page":"R291","DOI":"10.1152\/ajpregu.90497.2008","article-title":"Forced catch-up growth after fetal protein restriction alters the adipose tissue gene expression program leading to obesity in adult mice","volume":"297","author":"Bol","year":"2009","journal-title":"Am. J. Physiol. Regul. Integr. Comp. Physiol."},{"issue":"12","key":"10.1016\/j.brainres.2020.146906_b0040","doi-asserted-by":"crossref","first-page":"2760","DOI":"10.1038\/oby.2008.417","article-title":"Postnatal catch-up growth after fetal protein restriction programs proliferation of rat preadipocytes","volume":"16","author":"Bol","year":"2008","journal-title":"Obesity (Silver Spring)"},{"issue":"8","key":"10.1016\/j.brainres.2020.146906_b0045","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1111\/j.1365-2826.2007.01563.x","article-title":"Development of leptin-sensitive circuits","volume":"19","author":"Bouret","year":"2007","journal-title":"J. Neuroendocrinol."},{"issue":"11","key":"10.1016\/j.brainres.2020.146906_b0050","doi-asserted-by":"crossref","first-page":"2797","DOI":"10.1523\/JNEUROSCI.5369-03.2004","article-title":"Formation of projection pathways from the arcuate nucleus of the hypothalamus to hypothalamic regions implicated in the neural control of feeding behavior in mice","volume":"24","author":"Bouret","year":"2004","journal-title":"J. Neurosci."},{"issue":"Suppl 2","key":"10.1016\/j.brainres.2020.146906_b0055","doi-asserted-by":"crossref","first-page":"S19","DOI":"10.1038\/ijosup.2012.17","article-title":"Nutritional programming of hypothalamic development: critical periods and windows of opportunity","volume":"2","author":"Bouret","year":"2012","journal-title":"Int. J. Obes Suppl."},{"key":"10.1016\/j.brainres.2020.146906_b0060","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0083-6729(08)60393-3","article-title":"Experimental obesity: a homeostatic failure due to defective nutrient stimulation of the sympathetic nervous system","volume":"45","author":"Bray","year":"1989","journal-title":"Vitam Horm"},{"issue":"25","key":"10.1016\/j.brainres.2020.146906_b0065","doi-asserted-by":"crossref","first-page":"15043","DOI":"10.1073\/pnas.95.25.15043","article-title":"The neuropeptide Y\/agouti gene-related protein (AGRP) brain circuitry in normal, anorectic, and monosodium glutamate-treated mice","volume":"95","author":"Broberger","year":"1998","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"issue":"2","key":"10.1016\/j.brainres.2020.146906_b0070","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1055\/s-0028-1093890","article-title":"Diurnal changes in the concentrations of plasma lipids, sugars, insulin and corticosterone in rats fed diets containing various carbohydrates","volume":"6","author":"Bruckdorfer","year":"1974","journal-title":"Horm. Metab. Res."},{"issue":"5223","key":"10.1016\/j.brainres.2020.146906_b0075","doi-asserted-by":"crossref","first-page":"546","DOI":"10.1126\/science.7624778","article-title":"Recombinant mouse OB protein: evidence for a peripheral signal linking adiposity and central neural networks","volume":"269","author":"Campfield","year":"1995","journal-title":"Science"},{"issue":"1","key":"10.1016\/j.brainres.2020.146906_b0080","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1159\/000462972","article-title":"World Perspective on the Epidemiology of Stunting between 1990 and 2015","volume":"88","author":"Campisi","year":"2017","journal-title":"Hormone Res. Paediatr."},{"key":"10.1016\/j.brainres.2020.146906_b0085","doi-asserted-by":"crossref","first-page":"1840","DOI":"10.1100\/tsw.2010.173","article-title":"The melanocortin system in control of inflammation","volume":"10","author":"Catania","year":"2010","journal-title":"Sci. World J."},{"issue":"3","key":"10.1016\/j.brainres.2020.146906_b0090","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1016\/0306-4522(86)90039-4","article-title":"Osmotic stimulation causes structural plasticity of neurone-glia relationships of the oxytocin but not vasopressin secreting neurones in the hypothalamic supraoptic nucleus","volume":"17","author":"Chapman","year":"1986","journal-title":"Neuroscience"},{"issue":"5","key":"10.1016\/j.brainres.2020.146906_b0095","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1056\/NEJM199602013340503","article-title":"Serum immunoreactive-leptin concentrations in normal-weight and obese humans","volume":"334","author":"Considine","year":"1996","journal-title":"N. Engl. J. Med."},{"issue":"3","key":"10.1016\/j.brainres.2020.146906_b0100","doi-asserted-by":"crossref","first-page":"R813","DOI":"10.1152\/ajpregu.00201.2009","article-title":"The timing of \u201ccatch-up growth\u201d affects metabolism and appetite regulation in male rats born with intrauterine growth restriction","volume":"297","author":"Coup\u00e9","year":"2009","journal-title":"Am. J. Physiol. Regul. Integr. Comp. Physiol."},{"issue":"6836","key":"10.1016\/j.brainres.2020.146906_b0105","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1038\/35078085","article-title":"Leptin activates anorexigenic POMC neurons through a neural network in the arcuate nucleus","volume":"411","author":"Cowley","year":"2001","journal-title":"Nature"},{"issue":"5","key":"10.1016\/j.brainres.2020.146906_b0110","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0064220","article-title":"Increased leptin response and inhibition of apoptosis in thymocytes of young rats offspring from protein deprived dams during lactation","volume":"8","author":"da Silva","year":"2013","journal-title":"PLoS ONE"},{"issue":"3\u20134","key":"10.1016\/j.brainres.2020.146906_b0115","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1007\/s10540-005-2888-3","article-title":"Neonatal programming of body weight regulation and energetic metabolism","volume":"25","author":"de Moura","year":"2005","journal-title":"Biosci. Rep."},{"key":"10.1016\/j.brainres.2020.146906_b0120","doi-asserted-by":"crossref","unstructured":"de Souza AS, Fernandes FS, do Carmo M (2011). Effects of maternal malnutrition and postnatal nutritional rehabilitation on brain fatty acids, learning, and memory. Nutr Rev, 69(3), 132-144. doi:10.1111\/j.1753-4887.2011.00374.x.","DOI":"10.1111\/j.1753-4887.2011.00374.x"},{"key":"10.1016\/j.brainres.2020.146906_b0125","unstructured":"de Souza Caldeira Filho, J. & Moura, A.S. (2000). Undernutrition during early lactation period induces metabolic imprinting leading to glucose homeostasis alteration in aged rats. Research Communications in Molecular Pathology and Pharmacology, 108(3-4), 213-226."},{"issue":"2","key":"10.1016\/j.brainres.2020.146906_b0130","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.tins.2012.12.005","article-title":"Hypothalamic control of energy balance: insights into the role of synaptic plasticity","volume":"36","author":"Dietrich","year":"2013","journal-title":"Trends Neurosci."},{"issue":"1 Suppl","key":"10.1016\/j.brainres.2020.146906_b0135","doi-asserted-by":"crossref","first-page":"265S","DOI":"10.1093\/ajcn\/82.1.265S","article-title":"The economics of obesity: dietary energy density and energy cost","volume":"82","author":"Drewnowski","year":"2005","journal-title":"Am. J. Clin. Nutr."},{"issue":"6","key":"10.1016\/j.brainres.2020.146906_b0140","doi-asserted-by":"crossref","first-page":"1375","DOI":"10.1016\/S0896-6273(00)80656-X","article-title":"Leptin activates hypothalamic CART neurons projecting to the spinal cord","volume":"21","author":"Elias","year":"1998","journal-title":"Neuron"},{"issue":"33","key":"10.1016\/j.brainres.2020.146906_b0145","doi-asserted-by":"crossref","first-page":"3854","DOI":"10.2174\/0929867321666140601163658","article-title":"Fetal programming of the human brain: is there a link with insurgence of neurodegenerative disorders in adulthood?","volume":"21","author":"Faa","year":"2014","journal-title":"Curr. Med. Chem."},{"issue":"5","key":"10.1016\/j.brainres.2020.146906_b0150","doi-asserted-by":"crossref","first-page":"922","DOI":"10.1017\/S0007114507750924","article-title":"Maternal low-protein diet during lactation programmes body composition and glucose homeostasis in the adult rat offspring","volume":"98","author":"Fagundes","year":"2007","journal-title":"Br. J. Nutr."},{"issue":"12","key":"10.1016\/j.brainres.2020.146906_b0155","doi-asserted-by":"crossref","first-page":"866","DOI":"10.1055\/s-0029-1233457","article-title":"Temporal evaluation of body composition, glucose homeostasis and lipid profile of male rats programmed by maternal protein restriction during lactation","volume":"41","author":"Fagundes","year":"2009","journal-title":"Horm. Metab. Res."},{"issue":"11","key":"10.1016\/j.brainres.2020.146906_b0160","doi-asserted-by":"crossref","first-page":"1967","DOI":"10.1093\/jn\/117.11.1967","article-title":"Effect of repeated reproductive cycles on maternal nutritional status, lactational performance and litter growth in ad libitum-fed and chronically food-restricted rats","volume":"117","author":"Fischbeck","year":"1987","journal-title":"J. Nutr."},{"issue":"1","key":"10.1016\/j.brainres.2020.146906_b0165","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1038\/nm1525","article-title":"Anorectic estrogen mimics leptin's effect on the rewiring of melanocortin cells and Stat3 signaling in obese animals","volume":"13","author":"Gao","year":"2007","journal-title":"Nat. Med."},{"issue":"1\u20132","key":"10.1016\/j.brainres.2020.146906_b0170","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/0006-8993(86)91287-4","article-title":"Synaptic remodelling in arcuate nucleus after injection of estradiol valerate in adult female rats","volume":"366","author":"Garcia-Segura","year":"1986","journal-title":"Brain Res."},{"issue":"2","key":"10.1016\/j.brainres.2020.146906_b0175","doi-asserted-by":"crossref","first-page":"614S","DOI":"10.1093\/ajcn\/85.2.614S","article-title":"Nutrition and the developing brain: nutrient priorities and measurement","volume":"85","author":"Georgieff","year":"2007","journal-title":"Am. J. Clin. Nutr."},{"issue":"10","key":"10.1016\/j.brainres.2020.146906_b0180","doi-asserted-by":"crossref","first-page":"1289","DOI":"10.1038\/nn1548","article-title":"Agouti-related peptide-expressing neurons are mandatory for feeding","volume":"8","author":"Gropp","year":"2005","journal-title":"Nat. Neurosci."},{"issue":"11","key":"10.1016\/j.brainres.2020.146906_b0185","doi-asserted-by":"crossref","first-page":"5395","DOI":"10.1210\/en.2010-0681","article-title":"Corticosterone regulates synaptic input organization of POMC and NPY\/AgRP neurons in adult mice","volume":"151","author":"Gyengesi","year":"2010","journal-title":"Endocrinology"},{"issue":"5","key":"10.1016\/j.brainres.2020.146906_b0190","doi-asserted-by":"crossref","first-page":"508","DOI":"10.1016\/j.psyneuen.2007.03.004","article-title":"Anti-inflammatory agents attenuate the passive responses of guinea pig pups: evidence for stress-induced sickness behavior during maternal separation","volume":"32","author":"Hennessy","year":"2007","journal-title":"Psychoneuroendocrinology"},{"issue":"10","key":"10.1016\/j.brainres.2020.146906_b0195","doi-asserted-by":"crossref","first-page":"1788","DOI":"10.1016\/j.peptides.2004.11.038","article-title":"Feeding effects of melanocortin ligands-a historical perspective","volume":"26","author":"Irani","year":"2005","journal-title":"Peptides"},{"issue":"2","key":"10.1016\/j.brainres.2020.146906_b0200","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1016\/S0896-6273(00)80934-4","article-title":"Appetite and body weight regulation: is it all in the brain?","volume":"19","author":"Kalra","year":"1997","journal-title":"Neuron"},{"issue":"2","key":"10.1016\/j.brainres.2020.146906_b0205","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1210\/en.2013-1480","article-title":"Neural input is critical for arcuate hypothalamic neurons to mount intracellular signaling responses to systemic insulin and deoxyglucose challenges in male rats: implications for communication within feeding and metabolic control networks","volume":"155","author":"Khan","year":"2014","journal-title":"Endocrinology"},{"issue":"6","key":"10.1016\/j.brainres.2020.146906_b0210","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1093\/jn\/100.6.691","article-title":"Periodicity of food intake and lipogenesis in rats subjected to two different feeding plans","volume":"100","author":"Kimura","year":"1970","journal-title":"J. Nutr."},{"issue":"2","key":"10.1016\/j.brainres.2020.146906_b0215","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/j.cmet.2009.06.011","article-title":"Leptin acts via leptin receptor-expressing lateral hypothalamic neurons to modulate the mesolimbic dopamine system and suppress feeding","volume":"10","author":"Leinninger","year":"2009","journal-title":"Cell Metab."},{"issue":"1","key":"10.1016\/j.brainres.2020.146906_b0220","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1179\/147683010X12611460763805","article-title":"Glycogen stores are impaired in hypothalamic nuclei of rats malnourished during early life","volume":"13","author":"Lima","year":"2010","journal-title":"Nutr. Neurosci."},{"issue":"5","key":"10.1016\/j.brainres.2020.146906_b0225","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1097\/01.mop.0000245360.13949.91","article-title":"The effect of childhood malnutrition on externalizing behavior","volume":"18","author":"Liu","year":"2006","journal-title":"Curr. Opin. Pediatr."},{"issue":"3","key":"10.1016\/j.brainres.2020.146906_b0230","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1016\/j.neuron.2011.11.027","article-title":"Fasting activation of AgRP neurons requires NMDA receptors and involves spinogenesis and increased excitatory tone","volume":"73","author":"Liu","year":"2012","journal-title":"Neuron"},{"issue":"2","key":"10.1016\/j.brainres.2020.146906_b0235","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1037\/bne0000234","article-title":"Maternal protein-free diet during lactation programs male Wistar rat offspring for increased novelty-seeking, locomotor activity, and visuospatial performance","volume":"132","author":"Lotufo","year":"2018","journal-title":"Behav. Neurosci."},{"issue":"4","key":"10.1016\/j.brainres.2020.146906_b0240","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1136\/adc.71.4.288","article-title":"Role of nutritional programming in determining adult morbidity","volume":"71","author":"Lucas","year":"1994","journal-title":"Arch. Dis. Child."},{"issue":"1\u20132","key":"10.1016\/j.brainres.2020.146906_b0245","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/S0166-4328(00)00164-9","article-title":"Behavioral effects of protein deprivation and rehabilitation in adult rats: relevance to morphological alterations in the hippocampal formation","volume":"112","author":"Lukoyanov","year":"2000","journal-title":"Behav. Brain Res."},{"issue":"3","key":"10.1016\/j.brainres.2020.146906_b0250","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1080\/10284150412331279809","article-title":"Hypothalamic nuclei nitric oxide synthase expression in rats malnourished during early lactation period","volume":"7","author":"Marcelino","year":"2004","journal-title":"Nutr. Neurosci."},{"issue":"3","key":"10.1016\/j.brainres.2020.146906_b0255","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1016\/j.cmet.2008.01.007","article-title":"Activation of Stat3 signaling in AgRP neurons promotes locomotor activity","volume":"7","author":"Mesaros","year":"2008","journal-title":"Cell Metab."},{"issue":"1","key":"10.1016\/j.brainres.2020.146906_b0260","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1080\/10284150500049886","article-title":"Myelin basic protein accumulation is impaired in a model of protein deficiency during development","volume":"8","author":"Montanha-Rojas","year":"2005","journal-title":"Nutr. Neurosci."},{"issue":"1","key":"10.1016\/j.brainres.2020.146906_b0265","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/S0149-7634(05)80234-9","article-title":"Prenatal malnutrition and development of the brain","volume":"17","author":"Morgane","year":"1993","journal-title":"Neurosci. Biobehav. Rev."},{"issue":"4","key":"10.1016\/j.brainres.2020.146906_b0270","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1016\/S0149-7634(02)00012-X","article-title":"Effects of prenatal protein malnutrition on the hippocampal formation","volume":"26","author":"Morgane","year":"2002","journal-title":"Neurosci. Biobehav. Rev."},{"issue":"1","key":"10.1016\/j.brainres.2020.146906_b0275","first-page":"73","article-title":"Undernutrition during early lactation as an alternative model to study the onset of diabetes mellitus type II","volume":"92","author":"Moura","year":"1996","journal-title":"Res. Commun. Mol. Pathol. Pharmacol."},{"issue":"4","key":"10.1016\/j.brainres.2020.146906_b0280","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1159\/000065889","article-title":"Association between nutrition and gender during lactation influencing glucose homeostasis and blood pressure of the adult offspring","volume":"82","author":"Moura","year":"2002","journal-title":"Biol. Neonate"},{"issue":"2","key":"10.1016\/j.brainres.2020.146906_b0285","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1177\/1933719107301059","article-title":"Estrogen-induced hypothalamic synaptic plasticity and pituitary sensitization in the control of the estrogen-induced gonadotrophin surge","volume":"14","author":"Naftolin","year":"2007","journal-title":"Reprod. Sci."},{"issue":"2","key":"10.1016\/j.brainres.2020.146906_b0290","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1046\/j.1365-2265.2003.01839.x","article-title":"Appetite regulation: from the gut to the hypothalamus","volume":"60","author":"Neary","year":"2004","journal-title":"Clin. Endocrinol. (Oxf)"},{"issue":"8","key":"10.1016\/j.brainres.2020.146906_b0295","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1016\/j.tem.2004.07.009","article-title":"Insulin and its evolving partnership with leptin in the hypothalamic control of energy homeostasis","volume":"15","author":"Niswender","year":"2004","journal-title":"Trends Endocrinol. Metab."},{"issue":"6","key":"10.1016\/j.brainres.2020.146906_b0300","doi-asserted-by":"crossref","first-page":"1486","DOI":"10.1210\/endo-96-6-1486","article-title":"Effects of age and obesity on insulin binding to isolated adipocytes","volume":"96","author":"Olefsky","year":"1975","journal-title":"Endocrinology"},{"issue":"7","key":"10.1016\/j.brainres.2020.146906_b0305","doi-asserted-by":"crossref","first-page":"990","DOI":"10.1038\/ijo.2010.223","article-title":"Perinatal nutrient restriction induces long-lasting alterations in the circadian expression pattern of genes regulating food intake and energy metabolism","volume":"35","author":"Orozco-Sol\u00eds","year":"2011","journal-title":"Int. J. Obes. (Lond.)"},{"issue":"8","key":"10.1016\/j.brainres.2020.146906_b0310","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1016\/j.tins.2007.06.004","article-title":"Is dopamine a physiologically relevant mediator of feeding behavior?","volume":"30","author":"Palmiter","year":"2007","journal-title":"Trends Neurosci."},{"issue":"1\u20133","key":"10.1016\/j.brainres.2020.146906_b0315","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1159\/000204100","article-title":"Induction of NPY\/AgRP orexigenic peptide expression in rat hypothalamus is an early event in fasting: relationship with circulating leptin, insulin and glucose","volume":"23","author":"Palou","year":"2009","journal-title":"Cell. Physiol. Biochem."},{"key":"10.1016\/j.brainres.2020.146906_b0320","doi-asserted-by":"crossref","first-page":"1603","DOI":"10.1016\/S0271-5317(00)00246-3","article-title":"Short and long term effects of malnutrition in rats during lactation on the body weight of offspring","volume":"20","author":"Passos","year":"2000","journal-title":"Nutr. Res."},{"key":"10.1016\/j.brainres.2020.146906_b0325","unstructured":"Paxinos G. & Watson C. (1998). The Rat Brain in Stereotaxic Coordinates, 4th edition, San Diego, Academic Press."},{"issue":"6","key":"10.1016\/j.brainres.2020.146906_b0330","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1055\/s-2007-978627","article-title":"Effects of early protein restriction and adult obesity on rat pancreatic hormone content and glucose tolerance","volume":"32","author":"Petry","year":"2000","journal-title":"Horm. Metab. Res."},{"issue":"5667","key":"10.1016\/j.brainres.2020.146906_b0335","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1126\/science.1089459","article-title":"Rapid rewiring of arcuate nucleus feeding circuits by leptin","volume":"304","author":"Pinto","year":"2004","journal-title":"Science"},{"key":"10.1016\/j.brainres.2020.146906_b0340","doi-asserted-by":"crossref","unstructured":"Qasem, R.J., Yablonski, E., Li, J., Tang, H.M., Pontiggia, L., D'mello, A.P. (2012). Elucidation of thrifty features in adult rats exposed to protein restriction during gestation and lactation. Physiology & Behavior, 105(5), 1182-1193. 10.1016\/j.physbeh.2011.12.010.","DOI":"10.1016\/j.physbeh.2011.12.010"},{"issue":"11","key":"10.1016\/j.brainres.2020.146906_b0345","doi-asserted-by":"crossref","first-page":"1939","DOI":"10.1093\/jn\/123.11.1939","article-title":"AIN-93 purified diets for laboratory rodents: final report of the American Institute of Nutrition ad hoc writing committee on the reformulation of the AIN-76A rodent diet","volume":"123","author":"Reeves","year":"1993","journal-title":"J. Nutr."},{"key":"10.1016\/j.brainres.2020.146906_b0350","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1016\/j.neuroscience.2013.10.040","article-title":"Undernutrition during early life alters neuropeptide Y distribution along the arcuate\/paraventricular pathway","volume":"256","author":"Rocha","year":"2014","journal-title":"Neuroscience"},{"key":"10.1016\/j.brainres.2020.146906_b0355","doi-asserted-by":"crossref","unstructured":"Rotta, L.N., Schmidt, A.P., Mello e Souza, T., Nogueira, C.W., Souza, K.B., Izquierdo, I.A., Souza, D.O. (2003). Effects of undernutrition on glutamatergic parameters in rat brain. Neurochemical Research, 28(8), 1181-1186.","DOI":"10.1023\/A:1024272227219"},{"issue":"4","key":"10.1016\/j.brainres.2020.146906_b0360","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1016\/j.dhjo.2016.03.003","article-title":"Food insufficiency and food insecurity as risk factors for physical disability among Palestinian refugees in Lebanon: Evidence from an observational study","volume":"9","author":"Salti","year":"2016","journal-title":"Disabil. Health J."},{"issue":"1","key":"10.1016\/j.brainres.2020.146906_b0365","first-page":"8","article-title":"Up-regulation of phosphatidylinositol 3-kinase and glucose transporter 4 in muscle of rats subjected to maternal undernutrition","volume":"1639","author":"Sampaio de Freitas","year":"2003","journal-title":"BBA"},{"issue":"2","key":"10.1016\/j.brainres.2020.146906_b0370","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1152\/ajplegacy.1969.216.2.373","article-title":"Dietary obesity in rats: influence of diet, weight, age, and sex on body composition","volume":"216","author":"Schemmel","year":"1969","journal-title":"Am. J. Physiol."},{"issue":"2","key":"10.1016\/j.brainres.2020.146906_b0375","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1016\/j.bbr.2005.08.022","article-title":"Alpha-melanocyte stimulating hormone reduces putative stress-induced sickness behaviors in isolated guinea pig pups","volume":"168","author":"Schiml-Webb","year":"2006","journal-title":"Behavioral Brain Research"},{"issue":"6778","key":"10.1016\/j.brainres.2020.146906_b0380","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1038\/35007534","article-title":"Central nervous system control of food intake","volume":"404","author":"Schwartz","year":"2000","journal-title":"Nature"},{"issue":"2","key":"10.1016\/j.brainres.2020.146906_b0385","doi-asserted-by":"crossref","first-page":"147","DOI":"10.2337\/diab.44.2.147","article-title":"Effect of intracerebroventricular insulin infusion on diabetic hyperphagia and hypothalamic neuropeptide gene expression","volume":"44","author":"Sipols","year":"1995","journal-title":"Diabetes"},{"issue":"3","key":"10.1016\/j.brainres.2020.146906_b0390","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1016\/j.neuro.2012.02.015","article-title":"Interrelationships of undernutrition and neurotoxicity: food for thought and research attention","volume":"33","author":"Spencer","year":"2012","journal-title":"Neurotoxicology"},{"issue":"3","key":"10.1016\/j.brainres.2020.146906_b0395","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1002\/j.1550-8528.1996.tb00548.x","article-title":"\u201cDiet, exercise and behavior therapy\u201d: a cautionary tale","volume":"4","author":"Stunkard","year":"1996","journal-title":"Obes Res"},{"issue":"12","key":"10.1016\/j.brainres.2020.146906_b0400","doi-asserted-by":"crossref","first-page":"831","DOI":"10.1093\/qjmed\/hcw171","article-title":"Famine and disease in Nigerian refugee camps for internally displaced peoples: a sad reflection of our times","volume":"109","author":"Taylor-Robinson","year":"2016","journal-title":"QJM Int. J. Med."},{"issue":"6081","key":"10.1016\/j.brainres.2020.146906_b0405","doi-asserted-by":"crossref","first-page":"738","DOI":"10.1038\/322738a0","article-title":"Oxytocin induces morphological plasticity in the adult hypothalamo-neurohypophysial system","volume":"322","author":"Theodosis","year":"1986","journal-title":"Nature"},{"issue":"9","key":"10.1016\/j.brainres.2020.146906_b0410","doi-asserted-by":"crossref","first-page":"998","DOI":"10.1038\/nn.2167","article-title":"Synaptic release of GABA by AgRP neurons is required for normal regulation of energy balance","volume":"11","author":"Tong","year":"2008","journal-title":"Nat. Neurosci."},{"issue":"6806","key":"10.1016\/j.brainres.2020.146906_b0415","doi-asserted-by":"crossref","first-page":"908","DOI":"10.1038\/35038090","article-title":"Ghrelin induces adiposity in rodents","volume":"407","author":"Tsch\u00f6p","year":"2000","journal-title":"Nature"},{"issue":"11","key":"10.1016\/j.brainres.2020.146906_b0420","doi-asserted-by":"crossref","first-page":"3929","DOI":"10.1210\/en.2017-00452","article-title":"Short-term high-fat diet increases leptin activation of CART neurons and advances puberty in female mice","volume":"158","author":"Venancio","year":"2017","journal-title":"Endocrinology"},{"issue":"10","key":"10.1016\/j.brainres.2020.146906_b0425","doi-asserted-by":"crossref","first-page":"RC5","DOI":"10.1523\/JNEUROSCI.19-10-j0006.1999","article-title":"Neurochemical characterization of hypothalamic cocaine- amphetamine-regulated transcript neurons","volume":"19","author":"Vrang","year":"1999","journal-title":"J. Neurosci."},{"issue":"1","key":"10.1016\/j.brainres.2020.146906_b0430","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1016\/j.neuron.2011.05.028","article-title":"Leptin action on GABAergic neurons prevents obesity and reduces inhibitory tone to POMC neurons","volume":"71","author":"Vong","year":"2011","journal-title":"Neuron"},{"issue":"4","key":"10.1016\/j.brainres.2020.146906_b0435","doi-asserted-by":"crossref","first-page":"2065","DOI":"10.1172\/JCI118254","article-title":"Recombinant ob protein reduces feeding and body weight in the ob\/ob mouse","volume":"96","author":"Weigle","year":"1995","journal-title":"J. Clin. Investig."},{"issue":"3","key":"10.1016\/j.brainres.2020.146906_b0440","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1093\/jn\/89.3.300","article-title":"Cellular response in rats during malnutrition at various ages","volume":"89","author":"Winick","year":"1966","journal-title":"J. Nutr."},{"issue":"2","key":"10.1016\/j.brainres.2020.146906_b0445","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1203\/00006450-196903000-00010","article-title":"The effect of severe early malnutrition on cellular growth of human brain","volume":"3","author":"Winick","year":"1969","journal-title":"Pediatr. Res."},{"issue":"1","key":"10.1016\/j.brainres.2020.146906_b0450","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/S0196-9781(00)00367-3","article-title":"Paraventricular hypothalamic alpha-melanocyte-stimulating hormone and MTII reduce feeding without causing aversive effects","volume":"22","author":"Wirth","year":"2001","journal-title":"Peptides"},{"issue":"5738","key":"10.1016\/j.brainres.2020.146906_b0455","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1038\/282503a0","article-title":"Chronic intracerebroventricular infusion of insulin reduces food intake and body weight of baboons","volume":"282","author":"Woods","year":"1979","journal-title":"Nature"},{"issue":"2","key":"10.1016\/j.brainres.2020.146906_b0460","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1002\/jcb.21176","article-title":"Maternal protein restriction permanently programs adipocyte growth and development in adult male rat offspring","volume":"101","author":"Zhang","year":"2007","journal-title":"J. Cell. Biochem."},{"issue":"6505","key":"10.1016\/j.brainres.2020.146906_b0465","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1038\/372425a0","article-title":"Positional cloning of the mouse obese gene and its human homologue","volume":"372","author":"Zhang","year":"1994","journal-title":"Nature"}],"container-title":["Brain Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006899320302626?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006899320302626?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,13]],"date-time":"2025-09-13T18:10:17Z","timestamp":1757787017000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006899320302626"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,9]]},"references-count":93,"alternative-id":["S0006899320302626"],"URL":"https:\/\/doi.org\/10.1016\/j.brainres.2020.146906","relation":{},"ISSN":["0006-8993"],"issn-type":[{"type":"print","value":"0006-8993"}],"subject":[],"published":{"date-parts":[[2020,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Malnourishment during early lactation disrupts the ontogenetic distribution of the CART and \u03b1-MSH anorexigenic molecules in the arcuate\/paraventricular pathway and lateral hypothalamus in male rats","name":"articletitle","label":"Article Title"},{"value":"Brain Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.brainres.2020.146906","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"146906"}}