{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,5]],"date-time":"2026-11-05T12:25:51Z","timestamp":1793881551020,"version":"4.7.0"},"reference-count":48,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,11,1]],"date-time":"2020-11-01T00:00:00Z","timestamp":1604188800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,11,1]],"date-time":"2020-11-01T00:00:00Z","timestamp":1604188800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Brain Research"],"published-print":{"date-parts":[[2020,11]]},"DOI":"10.1016\/j.brainres.2020.146968","type":"journal-article","created":{"date-parts":[[2020,6,10]],"date-time":"2020-06-10T12:38:18Z","timestamp":1591792698000},"page":"146968","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":9,"special_numbering":"C","title":["Locomotor mal-performance and gait adaptability deficits in sickle cell mice are associated with vascular and white matter abnormalities and oxidative stress in cerebellum"],"prefix":"10.1016","volume":"1746","author":[{"given":"Luis E.F.","family":"Almeida","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0036-3410","authenticated-orcid":false,"given":"Li","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sayuri","family":"Kamimura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patricia M.","family":"Zerfas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meghann L.","family":"Smith","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Osorio L. Abath","family":"Neto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ticiana","family":"Vale","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martha M.","family":"Quezado","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iren","family":"Horkayne-Szakaly","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Wakim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zenaide M.N.","family":"Quezado","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.brainres.2020.146968_b0005","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1016\/j.ejpain.2004.11.001","article-title":"Human brain mechanisms of pain perception and regulation in health and disease","volume":"9","author":"Apkarian","year":"2005","journal-title":"Eur. J. Pain"},{"key":"10.1016\/j.brainres.2020.146968_b0010","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1016\/j.clineuro.2008.05.013","article-title":"Cerebellar neurocognition: insights into the bottom of the brain","volume":"110","author":"Baillieux","year":"2008","journal-title":"Clin. Neurol. Neurosurg."},{"key":"10.1016\/j.brainres.2020.146968_b0015","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/j.ejphar.2015.02.027","article-title":"Dexmedetomidine ameliorates nocifensive behavior in humanized sickle cell mice","volume":"754","author":"Calhoun","year":"2015","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.brainres.2020.146968_b0020","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.nicl.2016.12.024","article-title":"Characterization of functional brain activity and connectivity using EEG and fMRI in patients with sickle cell disease","volume":"14","author":"Case","year":"2017","journal-title":"Neuroimage Clin."},{"key":"10.1016\/j.brainres.2020.146968_b0025","doi-asserted-by":"crossref","unstructured":"Ceglie, G., Di Mauro, M., Tarissi De Jacobis, I., de Gennaro, F., Quaranta, M., Baronci, C., Villani, A., Palumbo, G., 2019. Gender-related differences in sickle cell disease in a pediatric cohort: a single-center retrospective study. Front. Mol. Biosci., 6.","DOI":"10.3389\/fmolb.2019.00140"},{"key":"10.1016\/j.brainres.2020.146968_b0030","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/j.nicl.2017.04.023","article-title":"Hemoglobin and mean platelet volume predicts diffuse T1-MRI white matter volume decrease in sickle cell disease patients","volume":"15","author":"Choi","year":"2017","journal-title":"NeuroImage Clin."},{"key":"10.1016\/j.brainres.2020.146968_b0035","doi-asserted-by":"crossref","first-page":"1055","DOI":"10.1002\/ajh.25570","article-title":"Anemia predicts lower white matter volume and cognitive performance in sickle and non-sickle cell anemia syndrome","volume":"94","author":"Choi","year":"2019","journal-title":"Am. J. Hematol."},{"key":"10.1016\/j.brainres.2020.146968_b0040","doi-asserted-by":"crossref","first-page":"1678","DOI":"10.1212\/WNL.50.6.1678","article-title":"Cognitive screening examinations for silent cerebral infarcts in sickle cell disease","volume":"50","author":"DeBaun","year":"1998","journal-title":"Neurology"},{"key":"10.1016\/j.brainres.2020.146968_b0045","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1182\/blood-2015-09-618579","article-title":"Central nervous system complications and management in sickle cell disease","volume":"127","author":"DeBaun","year":"2016","journal-title":"Blood"},{"key":"10.1016\/j.brainres.2020.146968_b0050","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1007\/s11910-019-0932-0","article-title":"Neurologic complications of sickle cell disease","volume":"19","author":"Farooq","year":"2019","journal-title":"Curr. Neurol. Neurosci. Rep."},{"key":"10.1016\/j.brainres.2020.146968_b0055","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1080\/10245330410001714185","article-title":"Arginine supplementation improves rotorod performance in sickle transgenic mice","volume":"9","author":"Fasipe","year":"2004","journal-title":"Hematology"},{"key":"10.1016\/j.brainres.2020.146968_b0060","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1016\/j.pain.2013.12.018","article-title":"Systemic dexmedetomidine augments inhibitory synaptic transmission in the superficial dorsal horn through activation of descending noradrenergic control: an in vivo patch-clamp analysis of analgesic mechanisms","volume":"155","author":"Funai","year":"2014","journal-title":"Pain"},{"key":"10.1016\/j.brainres.2020.146968_b0065","doi-asserted-by":"crossref","unstructured":"Gladwin, M.T., Barst, R.J., Gibbs, J.S., Hildesheim, M., Sachdev, V., Nouraie, M., Hassell, K.L., Little, J.A., Schraufnagel, D.E., Krishnamurti, L., Novelli, E., Girgis, R.E., Morris, C.R., Berman Rosenzweig, E., Badesch, D.B., Lanzkron, S., Castro, O.L., Taylor, J.G.t., Goldsmith, J.C., Kato, G.J., Gordeuk, V.R., Machado, R.F., 2014. Risk factors for death in 632 patients with sickle cell disease in the United States and United Kingdom. PLoS One. 9, e99489.","DOI":"10.1371\/journal.pone.0099489"},{"key":"10.1016\/j.brainres.2020.146968_b0070","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1097\/DBP.0b013e31829c3c48","article-title":"Neurodevelopmental deficits among infants and toddlers with sickle cell disease","volume":"34","author":"Glass","year":"2013","journal-title":"J. Dev. Behav. Pediatr."},{"key":"10.1016\/j.brainres.2020.146968_b0075","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1124\/pr.57.2.4","article-title":"The blood-brain barrier\/neurovascular unit in health and disease","volume":"57","author":"Hawkins","year":"2005","journal-title":"Pharmacol. Rev."},{"key":"10.1016\/j.brainres.2020.146968_b0080","doi-asserted-by":"crossref","first-page":"927","DOI":"10.3389\/fneur.2019.00927","article-title":"Impaired motor learning following a pain episode in intact rats","volume":"10","author":"Huot-Lavoie","year":"2019","journal-title":"Front. Neurol."},{"key":"10.1016\/j.brainres.2020.146968_b0085","doi-asserted-by":"crossref","first-page":"2913","DOI":"10.1093\/brain\/awn246","article-title":"The influence of focal cerebellar lesions on the control and adaptation of gait","volume":"131","author":"Ilg","year":"2008","journal-title":"Brain"},{"key":"10.1016\/j.brainres.2020.146968_b0090","doi-asserted-by":"crossref","first-page":"2571","DOI":"10.1111\/trf.13745","article-title":"Testosterone-dependent sex differences in red blood cell hemolysis in storage, stress, and disease","volume":"56","author":"Kanias","year":"2016","journal-title":"Transfusion"},{"key":"10.1016\/j.brainres.2020.146968_b0095","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1111\/bjh.12496","article-title":"Subcortical and cerebellar volumetric deficits in paediatric sickle cell anaemia","volume":"163","author":"Kawadler","year":"2013","journal-title":"Br. J. Haematol."},{"key":"10.1016\/j.brainres.2020.146968_b0100","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1177\/1535370214544275","article-title":"Sickle cell disease in mice is associated with sensitization of sensory nerve fibers","volume":"240","author":"Kenyon","year":"2015","journal-title":"Exp. Biol. Med. (Maywood)"},{"key":"10.1016\/j.brainres.2020.146968_b0105","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1016\/j.bcmd.2015.08.001","article-title":"Rapamycin increases fetal hemoglobin and ameliorates the nociception phenotype in sickle cell mice","volume":"55","author":"Khaibullina","year":"2015","journal-title":"Blood Cells Mol. Dis."},{"key":"10.1016\/j.brainres.2020.146968_b0110","doi-asserted-by":"crossref","DOI":"10.3324\/haematol.2017.180992","article-title":"RON kinase inhibition reduces renal endothelial injury in sickle cell disease mice","volume":"103","author":"Khaibullina","year":"2018","journal-title":"Haematologica"},{"key":"10.1016\/j.brainres.2020.146968_b0115","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1016\/j.gaitpost.2012.09.001","article-title":"Effects of task constraints on obstacle avoidance strategies in patients with cerebellar disease","volume":"37","author":"Kim","year":"2013","journal-title":"Gait Posture"},{"key":"10.1016\/j.brainres.2020.146968_b0120","doi-asserted-by":"crossref","first-page":"835","DOI":"10.1212\/WNL.0000000000000188","article-title":"Neuroimaging abnormalities in adults with sickle cell anemia: associations with cognition","volume":"82","author":"Mackin","year":"2014","journal-title":"Neurology"},{"key":"10.1016\/j.brainres.2020.146968_b0125","doi-asserted-by":"crossref","first-page":"1651","DOI":"10.1182\/blood-2005-07-2839","article-title":"Pathology of Berkeley sickle cell mice: similarities and differences with human sickle cell disease","volume":"107","author":"Manci","year":"2006","journal-title":"Blood"},{"key":"10.1016\/j.brainres.2020.146968_b0130","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1097\/MPH.0000000000001266","article-title":"Visual motor integration in children with sickle cell disease","volume":"40","author":"Newby","year":"2018","journal-title":"J. Pediatr. Hematol. Oncol."},{"key":"10.1016\/j.brainres.2020.146968_b0135","doi-asserted-by":"crossref","first-page":"876","DOI":"10.1126\/science.278.5339.876","article-title":"Transgenic knockout mice with exclusively human sickle hemoglobin and sickle cell disease","volume":"278","author":"Paszty","year":"1997","journal-title":"Science"},{"key":"10.1016\/j.brainres.2020.146968_b0140","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1097\/AJP.0b013e31814da3eb","article-title":"Fear of movement (kinesiophobia), pain, and psychopathology in patients with sickle cell disease","volume":"23","author":"Pells","year":"2007","journal-title":"Clin. J. Pain"},{"key":"10.1016\/j.brainres.2020.146968_b0145","doi-asserted-by":"crossref","first-page":"1639","DOI":"10.1056\/NEJM199406093302303","article-title":"Mortality in sickle cell disease. Life expectancy and risk factors for early death","volume":"330","author":"Platt","year":"1994","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.brainres.2020.146968_b0150","doi-asserted-by":"crossref","unstructured":"Rahmati, N., Vinueza Veloz, M.F., Xu, J., Barone, S., Rodolfo Ben Hamida, N., Schonewille, M., Hoebeek, F.E., Soleimani, M., De Zeeuw, C.I., 2016. SLC26A11 (KBAT) in purkinje cells is critical for inhibitory transmission and contributes to locomotor coordination. eNeuro. 3.","DOI":"10.1523\/ENEURO.0028-16.2016"},{"key":"10.1016\/j.brainres.2020.146968_b0155","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1111\/j.1472-8206.2012.01068.x","article-title":"Pharmacological mechanisms involved in the antinociceptive effects of dexmedetomidine in mice","volume":"28","author":"Rangel","year":"2014","journal-title":"Fundam. Clin. Pharmacol."},{"key":"10.1016\/j.brainres.2020.146968_b0160","doi-asserted-by":"crossref","first-page":"E376","DOI":"10.1002\/ajh.25258","article-title":"Hemolysis and hemolysis-related complications in females vs. males with sickle cell disease","volume":"93","author":"Raslan","year":"2018","journal-title":"Am. J. Hematol."},{"key":"10.1016\/j.brainres.2020.146968_b0165","doi-asserted-by":"crossref","first-page":"1060","DOI":"10.1007\/s11606-013-2755-z","article-title":"Six persistent research misconceptions","volume":"29","author":"Rothman","year":"2014","journal-title":"J. Gen. Intern. Med."},{"key":"10.1016\/j.brainres.2020.146968_b0170","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1124\/jpet.116.237057","article-title":"Blood-brain barrier disruption and neurovascular unit dysfunction in diabetic mice: protection with the mitochondrial carbonic anhydrase inhibitor topiramate","volume":"359","author":"Salameh","year":"2016","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.brainres.2020.146968_b0175","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1016\/j.nic.2016.03.003","article-title":"The role of the pediatric cerebellum in motor functions, cognition, and behavior: a clinical perspective","volume":"26","author":"Salman","year":"2016","journal-title":"Neuroimaging Clin. N. Am."},{"key":"10.1016\/j.brainres.2020.146968_b0180","doi-asserted-by":"crossref","first-page":"3235","DOI":"10.1038\/s41467-018-05656-w","article-title":"Neonatal brain injury causes cerebellar learning deficits and Purkinje cell dysfunction","volume":"9","author":"Sathyanesan","year":"2018","journal-title":"Nat. Commun."},{"key":"10.1016\/j.brainres.2020.146968_b0185","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1097\/MPH.0b013e3182036f33","article-title":"White matter integrity and core cognitive function in children diagnosed with sickle cell disease","volume":"33","author":"Scantlebury","year":"2011","journal-title":"J. Pediatr. Hematol. Oncol."},{"key":"10.1016\/j.brainres.2020.146968_b0190","first-page":"382","article-title":"Cognitive impairment in children with hemoglobin SS sickle cell disease: relationship to MR imaging findings and hematocrit","volume":"24","author":"Steen","year":"2003","journal-title":"AJNR Am. J. Neuroradiol."},{"key":"10.1016\/j.brainres.2020.146968_b0195","doi-asserted-by":"crossref","first-page":"871","DOI":"10.3389\/fneur.2019.00871","article-title":"Vascular instability and neurological morbidity in sickle cell disease: an integrative framework","volume":"10","author":"Stotesbury","year":"2019","journal-title":"Front. Neurol."},{"key":"10.1016\/j.brainres.2020.146968_b0200","doi-asserted-by":"crossref","first-page":"721","DOI":"10.3945\/ajcn.115.113548","article-title":"Best (but oft-forgotten) practices: the multiple problems of multiplicity-whether and how to correct for many statistical tests","volume":"102","author":"Streiner","year":"2015","journal-title":"Am. J. Clin. Nutr."},{"key":"10.1016\/j.brainres.2020.146968_b0205","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1016\/j.neuron.2008.03.016","article-title":"Role of olivary electrical coupling in cerebellar motor learning","volume":"58","author":"Van Der Giessen","year":"2008","journal-title":"Neuron"},{"key":"10.1016\/j.brainres.2020.146968_b0210","doi-asserted-by":"crossref","first-page":"1823","DOI":"10.1001\/jama.2010.562","article-title":"Neuropsychological dysfunction and neuroimaging abnormalities in neurologically intact adults with sickle cell anemia","volume":"303","author":"Vichinsky","year":"2010","journal-title":"JAMA"},{"key":"10.1016\/j.brainres.2020.146968_b0215","doi-asserted-by":"crossref","first-page":"3513","DOI":"10.1007\/s00429-014-0870-1","article-title":"Cerebellar control of gait and interlimb coordination","volume":"220","author":"Vinueza Veloz","year":"2015","journal-title":"Brain Struct. Funct."},{"key":"10.1016\/j.brainres.2020.146968_b0220","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/j.nbd.2015.10.004","article-title":"Cognitive and behavior deficits in sickle cell mice are associated with profound neuropathologic changes in hippocampus and cerebellum","volume":"85","author":"Wang","year":"2016","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.brainres.2020.146968_b0225","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/j.niox.2018.08.005","article-title":"The role of nitrite in muscle function, susceptibility to contraction injury, and fatigability in sickle cell mice","volume":"80","author":"Wang","year":"2018","journal-title":"Nitric Oxide"},{"key":"10.1016\/j.brainres.2020.146968_b0230","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1067\/mpd.2001.116935","article-title":"Neuropsychologic performance in school-aged children with sickle cell disease: a report from the Cooperative Study of Sickle Cell Disease","volume":"139","author":"Wang","year":"2001","journal-title":"J. Pediatr."},{"key":"10.1016\/j.brainres.2020.146968_b0235","doi-asserted-by":"crossref","first-page":"1183","DOI":"10.1182\/blood-2006-02-004812","article-title":"Correction of sickle cell disease by homologous recombination in embryonic stem cells","volume":"108","author":"Wu","year":"2006","journal-title":"Blood"},{"key":"10.1016\/j.brainres.2020.146968_b0240","first-page":"101","article-title":"Simple assay for the level of total lipid peroxides in serum or plasma","volume":"108","author":"Yagi","year":"1998","journal-title":"Methods Mol. Biol."}],"container-title":["Brain Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006899320303243?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006899320303243?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,13]],"date-time":"2025-09-13T18:10:40Z","timestamp":1757787040000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006899320303243"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,11]]},"references-count":48,"alternative-id":["S0006899320303243"],"URL":"https:\/\/doi.org\/10.1016\/j.brainres.2020.146968","relation":{},"ISSN":["0006-8993"],"issn-type":[{"value":"0006-8993","type":"print"}],"subject":[],"published":{"date-parts":[[2020,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Locomotor mal-performance and gait adaptability deficits in sickle cell mice are associated with vascular and white matter abnormalities and oxidative stress in cerebellum","name":"articletitle","label":"Article Title"},{"value":"Brain Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.brainres.2020.146968","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"146968"}}