{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,29]],"date-time":"2026-06-29T21:32:43Z","timestamp":1782768763488,"version":"3.54.5"},"reference-count":57,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,11,1]],"date-time":"2020-11-01T00:00:00Z","timestamp":1604188800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,11,1]],"date-time":"2020-11-01T00:00:00Z","timestamp":1604188800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100008853","name":"Jining Medical University","doi-asserted-by":"publisher","award":["JYFC2018KJ003"],"award-info":[{"award-number":["JYFC2018KJ003"]}],"id":[{"id":"10.13039\/501100008853","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81671276"],"award-info":[{"award-number":["81671276"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81501018"],"award-info":[{"award-number":["81501018"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007129","name":"Natural Science Foundation of Shandong Province","doi-asserted-by":"publisher","award":["ZR2014HL040"],"award-info":[{"award-number":["ZR2014HL040"]}],"id":[{"id":"10.13039\/501100007129","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Brain Research"],"published-print":{"date-parts":[[2020,11]]},"DOI":"10.1016\/j.brainres.2020.147023","type":"journal-article","created":{"date-parts":[[2020,7,22]],"date-time":"2020-07-22T11:15:42Z","timestamp":1595416542000},"page":"147023","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":33,"special_numbering":"C","title":["Ghrelin protects dopaminergic neurons against MPTP neurotoxicity through promoting autophagy and inhibiting endoplasmic reticulum mediated apoptosis"],"prefix":"10.1016","volume":"1746","author":[{"given":"Huiqing","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shanshan","family":"Dou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junge","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ziqi","family":"Shao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunmei","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Baohua","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.brainres.2020.147023_b0005","doi-asserted-by":"crossref","first-page":"40753","DOI":"10.1038\/srep40753","article-title":"Vanillic acid attenuates Abeta1-42-induced oxidative stress and cognitive impairment in mice","volume":"7","author":"Amin","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.brainres.2020.147023_b0010","doi-asserted-by":"crossref","first-page":"29739","DOI":"10.1074\/jbc.M600933200","article-title":"Phosphorylation of Ser-129 is the dominant pathological modification of alpha-synuclein in familial and sporadic Lewy body disease","volume":"281","author":"Anderson","year":"2006","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.brainres.2020.147023_b0015","doi-asserted-by":"crossref","first-page":"14057","DOI":"10.1523\/JNEUROSCI.3890-09.2009","article-title":"Ghrelin promotes and protects nigrostriatal dopamine function via a UCP2-dependent mitochondrial mechanism","volume":"29","author":"Andrews","year":"2009","journal-title":"J. Neurosci."},{"key":"10.1016\/j.brainres.2020.147023_b0020","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1038\/35072550","article-title":"Experimental models of Parkinson's disease","volume":"2","author":"Beal","year":"2001","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.brainres.2020.147023_b0025","doi-asserted-by":"crossref","first-page":"588","DOI":"10.1111\/j.1471-4159.2010.07143.x","article-title":"Induction of the unfolded protein response by alpha-synuclein in experimental models of Parkinson's disease","volume":"116","author":"Bellucci","year":"2011","journal-title":"J. Neurochem."},{"key":"10.1016\/j.brainres.2020.147023_b0030","doi-asserted-by":"crossref","first-page":"883","DOI":"10.4161\/auto.7.8.15538","article-title":"A fluorescence-microscopic and cytofluorometric system for monitoring the turnover of the autophagic substrate p62\/SQSTM1","volume":"7","author":"BenYoun\u00e8s","year":"2011","journal-title":"Autophagy"},{"key":"10.1016\/j.brainres.2020.147023_b0035","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1139\/Y10-010","article-title":"Methods for detecting autophagy and determining autophagy-induced cell death","volume":"88","author":"Chen","year":"2010","journal-title":"Can. J. Physiol. Pharmacol."},{"key":"10.1016\/j.brainres.2020.147023_b0040","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1038\/374733a0","article-title":"Induction of apoptosis by the Bcl-2 homologue Bak","volume":"374","author":"Chittenden","year":"1995","journal-title":"Nature"},{"key":"10.1016\/j.brainres.2020.147023_b0045","doi-asserted-by":"crossref","first-page":"2313","DOI":"10.1007\/s11064-018-2652-2","article-title":"SMER28 attenuates dopaminergic toxicity mediated by 6-hydroxydopamine in the rats via modulating oxidative burdens and autophagy-related parameters","volume":"43","author":"Darabi","year":"2018","journal-title":"Neurochem. Res."},{"key":"10.1016\/j.brainres.2020.147023_b0050","doi-asserted-by":"crossref","first-page":"4255","DOI":"10.1210\/endo.141.11.7757","article-title":"Ghrelin, a novel growth hormone-releasing acylated peptide, is synthesized in a distinct endocrine cell type in the gastrointestinal tracts of rats and humans","volume":"141","author":"Date","year":"2000","journal-title":"Endocrinology"},{"key":"10.1016\/j.brainres.2020.147023_b0055","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1002\/path.2697","article-title":"Autophagy: cellular and molecular mechanisms","volume":"221","author":"Glick","year":"2010","journal-title":"J. Pathol."},{"key":"10.1016\/j.brainres.2020.147023_b0060","doi-asserted-by":"crossref","first-page":"651","DOI":"10.2147\/NDT.S235562","article-title":"Phosphorylation of tau and \u03b1-synuclein induced neurodegeneration in MPTP mouse model of Parkinson's disease","volume":"16","author":"Hu","year":"2020","journal-title":"Neuropsychiatr. Dis. Treat."},{"key":"10.1016\/j.brainres.2020.147023_b0065","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1016\/j.neuroscience.2018.03.026","article-title":"Phosphorylated \u03b1-synuclein accumulations and lewy body-like pathology distributed in Parkinson's disease-related brain areas of aged rhesus monkeys treated with MPTP","volume":"379","author":"Huang","year":"2018","journal-title":"Neuroscience"},{"key":"10.1016\/j.brainres.2020.147023_b0070","doi-asserted-by":"crossref","first-page":"40282","DOI":"10.1074\/jbc.M508786200","article-title":"HDAC6 and microtubules are required for autophagic degradation of aggregated huntingtin","volume":"280","author":"Iwata","year":"2005","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.brainres.2020.147023_b0075","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/j.neuro.2015.08.005","article-title":"Suppression effects of O-demethyldemethoxycurcumin on thapsigargin triggered on endoplasmic reticulum stress in SK-N-SH cells","volume":"50","author":"Janyou","year":"2015","journal-title":"Neurotoxicology"},{"key":"10.1016\/j.brainres.2020.147023_b0080","doi-asserted-by":"crossref","first-page":"532","DOI":"10.1016\/j.expneurol.2008.05.006","article-title":"Ghrelin antagonizes MPTP-induced neurotoxicity to the dopaminergic neurons in mouse substantia nigra","volume":"212","author":"Jiang","year":"2008","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.brainres.2020.147023_b0085","first-page":"1732","article-title":"Apelin13 attenuates ER stressassociated apoptosis induced by MPP+ in SHSY5Y cells","volume":"42","author":"Jiang","year":"2018","journal-title":"Int. J. Mol. Med."},{"key":"10.1016\/j.brainres.2020.147023_b0090","doi-asserted-by":"crossref","first-page":"1442","DOI":"10.1002\/mds.26354","article-title":"Disease-modifying strategies for Parkinson's disease","volume":"30","author":"Kalia","year":"2015","journal-title":"Mov. Disord."},{"key":"10.1016\/j.brainres.2020.147023_b0095","doi-asserted-by":"crossref","first-page":"15240","DOI":"10.1074\/jbc.M312497200","article-title":"Alpha-synuclein up-regulation and aggregation during MPP+-induced apoptosis in neuroblastoma cells: intermediacy of transferrin receptor iron and hydrogen peroxide","volume":"279","author":"Kalivendi","year":"2004","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.brainres.2020.147023_b0100","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1016\/j.neuropharm.2017.08.015","article-title":"Metformin lowers \u03b1-synuclein phosphorylation and upregulates neurotrophic factor in the MPTP mouse model of Parkinson's disease","volume":"125","author":"Katila","year":"2017","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.brainres.2020.147023_b0105","doi-asserted-by":"crossref","first-page":"1211","DOI":"10.1101\/gad.13.10.1211","article-title":"Stress signaling from the lumen of the endoplasmic reticulum: coordination of gene transcriptional and translational controls","volume":"13","author":"Kaufman","year":"1999","journal-title":"Genes Dev."},{"key":"10.1016\/j.brainres.2020.147023_b0110","doi-asserted-by":"crossref","first-page":"979","DOI":"10.1126\/science.6823561","article-title":"Chronic Parkinsonism in humans due to a product of meperidine-analog synthesis","volume":"219","author":"Langston","year":"1983","journal-title":"Science"},{"key":"10.1016\/j.brainres.2020.147023_b0115","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1016\/j.ymeth.2004.10.010","article-title":"The ER chaperone and signaling regulator GRP78\/BiP as a monitor of endoplasmic reticulum stress","volume":"35","author":"Lee","year":"2005","journal-title":"Methods"},{"key":"10.1016\/j.brainres.2020.147023_b0120","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.cell.2007.12.018","article-title":"Autophagy in the pathogenesis of disease","volume":"132","author":"Levine","year":"2008","journal-title":"Cell"},{"key":"10.1016\/j.brainres.2020.147023_b0125","doi-asserted-by":"crossref","first-page":"672","DOI":"10.1038\/45257","article-title":"Induction of autophagy and inhibition of tumorigenesis by beclin 1","volume":"402","author":"Liang","year":"1999","journal-title":"Nature"},{"key":"10.1016\/j.brainres.2020.147023_b0130","doi-asserted-by":"crossref","first-page":"1403","DOI":"10.1038\/70978","article-title":"Inducible nitric oxide synthase stimulates dopaminergic neurodegeneration in the MPTP model of Parkinson disease","volume":"5","author":"Liberatore","year":"1999","journal-title":"Nat. Med."},{"key":"10.1016\/j.brainres.2020.147023_b0135","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1111\/j.1600-079X.2007.00456.x","article-title":"Melatonin attenuates arsenite-induced apoptosis in rat brain: involvement of mitochondrial and endoplasmic reticulum pathways and aggregation of alpha-synuclein","volume":"43","author":"Lin","year":"2007","journal-title":"J. Pineal Res."},{"key":"10.1016\/j.brainres.2020.147023_b0140","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a009357","article-title":"The role of autophagy in Parkinson's disease","volume":"2","author":"Lynch-Day","year":"2012","journal-title":"Cold Spring Harb. Perspect. Med."},{"key":"10.1016\/j.brainres.2020.147023_b0145","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1016\/j.jhep.2010.11.005","article-title":"Endoplasmic reticulum stress in liver disease","volume":"54","author":"Malhi","year":"2011","journal-title":"J. Hepatol."},{"key":"10.1016\/j.brainres.2020.147023_b0150","doi-asserted-by":"crossref","first-page":"1062","DOI":"10.1016\/j.cell.2009.03.048","article-title":"Autophagy suppresses tumorigenesis through elimination of p62","volume":"137","author":"Mathew","year":"2009","journal-title":"Cell"},{"key":"10.1016\/j.brainres.2020.147023_b0160","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1007\/s12640-009-9037-x","article-title":"Neuroprotective effect of ghrelin in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine mouse model of Parkinson's disease by blocking microglial activation","volume":"15","author":"Moon","year":"2009","journal-title":"Neurotox. Res."},{"key":"10.1016\/j.brainres.2020.147023_b0165","doi-asserted-by":"crossref","first-page":"206ra138","DOI":"10.1126\/scitranslmed.3006767","article-title":"Oral treatment targeting the unfolded protein response prevents neurodegeneration and clinical disease in prion-infected mice","volume":"5","author":"Moreno","year":"2013","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.brainres.2020.147023_b0170","doi-asserted-by":"crossref","first-page":"887","DOI":"10.1083\/jcb.150.4.887","article-title":"Cross-talk between two cysteine protease families. Activation of caspase-12 by calpain in apoptosis","volume":"150","author":"Nakagawa","year":"2000","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.brainres.2020.147023_b0175","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1038\/47513","article-title":"Caspase-12 mediates endoplasmic-reticulum-specific apoptosis and cytotoxicity by amyloid-beta","volume":"403","author":"Nakagawa","year":"2000","journal-title":"Nature"},{"key":"10.1016\/j.brainres.2020.147023_b0180","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1146\/annurev.neuro.22.1.123","article-title":"Etiology and pathogenesis of Parkinson's disease","volume":"22","author":"Olanow","year":"1999","journal-title":"Annu. Rev. Neurosci."},{"key":"10.1016\/j.brainres.2020.147023_b0185","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1016\/j.bbrc.2007.01.056","article-title":"Ire1 regulated XBP1 mRNA splicing is essential for the unfolded protein response (UPR) in Drosophila melanogaster","volume":"354","author":"Plongthongkum","year":"2007","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.brainres.2020.147023_b0190","doi-asserted-by":"crossref","first-page":"489","DOI":"10.2174\/138161211795164095","article-title":"The intranasal administration of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP): a new rodent model to test palliative and neuroprotective agents for Parkinson's disease","volume":"17","author":"Prediger","year":"2011","journal-title":"Curr. Pharm. Des."},{"key":"10.1016\/j.brainres.2020.147023_b0195","doi-asserted-by":"crossref","first-page":"C756","DOI":"10.1152\/ajpcell.00391.2006","article-title":"Endoplasmic reticulum stress and the unfolded protein response regulate genomic cystic fibrosis transmembrane conductance regulator expression","volume":"292","author":"Rab","year":"2007","journal-title":"Am. J. Physiol. Cell Physiol."},{"key":"10.1016\/j.brainres.2020.147023_b0200","doi-asserted-by":"crossref","first-page":"10690","DOI":"10.1523\/JNEUROSCI.22-24-10690.2002","article-title":"Endoplasmic reticulum stress and the unfolded protein response in cellular models of Parkinson's disease","volume":"22","author":"Ryu","year":"2002","journal-title":"J. Neurosci."},{"key":"10.1016\/j.brainres.2020.147023_b0205","doi-asserted-by":"crossref","first-page":"4374","DOI":"10.1074\/jbc.M115.705095","article-title":"Effects of serine 129 phosphorylation on \u03b1-synuclein aggregation, membrane association, and internalization","volume":"291","author":"Samuel","year":"2016","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.brainres.2020.147023_b0210","doi-asserted-by":"crossref","first-page":"271","DOI":"10.3389\/fnins.2019.00271","article-title":"On the role of aminochrome in mitochondrial dysfunction and endoplasmic reticulum stress in Parkinson's disease","volume":"13","author":"Segura-Aguilar","year":"2019","journal-title":"Front. Neurosci."},{"key":"10.1016\/j.brainres.2020.147023_b0215","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1146\/annurev-pathol-011110-130242","article-title":"Parkinson's disease: genetics and pathogenesis","volume":"6","author":"Shulman","year":"2011","journal-title":"Annu. Rev. Pathol."},{"key":"10.1016\/j.brainres.2020.147023_b0220","doi-asserted-by":"crossref","first-page":"974","DOI":"10.1111\/j.1471-4159.2005.03428.x","article-title":"CHOP\/GADD153 is a mediator of apoptotic death in substantia nigra dopamine neurons in an in vivo neurotoxin model of parkinsonism","volume":"95","author":"Silva","year":"2005","journal-title":"J. Neurochem."},{"key":"10.1016\/j.brainres.2020.147023_b0225","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1016\/j.neuroscience.2017.06.060","article-title":"Levodopa (L-DOPA) attenuates endoplasmic reticulum stress response and cell death signaling through DRD2 in SH-SY5Y neuronal cells under alpha-synuclein-induced toxicity","volume":"358","author":"Song","year":"2017","journal-title":"Neuroscience"},{"key":"10.1016\/j.brainres.2020.147023_b0230","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1007\/978-1-59745-157-4_4","article-title":"LC3 and autophagy","volume":"445","author":"Tanida","year":"2008","journal-title":"Methods Mol. Biol."},{"key":"10.1016\/j.brainres.2020.147023_b0235","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0016706","article-title":"Resistance to MPTP-neurotoxicity in alpha-synuclein knockout mice is complemented by human alpha-synuclein and associated with increased beta-synuclein and Akt activation","volume":"6","author":"Thomas","year":"2011","journal-title":"PLoS ONE"},{"key":"10.1016\/j.brainres.2020.147023_b0240","article-title":"Silymarin protects against impaired autophagy associated with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced Parkinsonism","author":"Tripathi","year":"2019","journal-title":"J. Mol. Neurosci."},{"key":"10.1016\/j.brainres.2020.147023_b0245","doi-asserted-by":"crossref","first-page":"664","DOI":"10.1126\/science.287.5453.664","article-title":"Coupling of stress in the ER to activation of JNK protein kinases by transmembrane protein kinase IRE1","volume":"287","author":"Urano","year":"2000","journal-title":"Science"},{"key":"10.1016\/j.brainres.2020.147023_b0250","doi-asserted-by":"crossref","first-page":"1081","DOI":"10.1126\/science.1209038","article-title":"The unfolded protein response: from stress pathway to homeostatic regulation","volume":"334","author":"Walter","year":"2011","journal-title":"Science"},{"key":"10.1016\/j.brainres.2020.147023_b0255","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s10495-016-1296-4","article-title":"The role of endoplasmic reticulum stress in neurodegenerative disease","volume":"22","author":"Xiang","year":"2017","journal-title":"Apoptosis"},{"key":"10.1016\/j.brainres.2020.147023_b0260","first-page":"1720621","article-title":"Alpha-synuclein in Parkinson's disease: from pathogenetic dysfunction to potential clinical application","volume":"2016","author":"Xu","year":"2016","journal-title":"Parkinsons Dis."},{"key":"10.1016\/j.brainres.2020.147023_b0265","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1016\/j.biocel.2018.12.011","article-title":"Protective effects of tanshinone IIA on SH-SY5Y cells against oAbeta1-42-induced apoptosis due to prevention of endoplasmic reticulum stress","volume":"107","author":"Yang","year":"2019","journal-title":"Int. J. Biochem. Cell Biol."},{"key":"10.1016\/j.brainres.2020.147023_b0270","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.jep.2016.12.053","article-title":"Jia-Jian-Di-Huang-Yin-Zi decoction reduces apoptosis induced by both mitochondrial and endoplasmic reticulum caspase12 pathways in the mouse model of Parkinson's disease","volume":"203","author":"Zhang","year":"2017","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.brainres.2020.147023_b0275","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2019.104538","article-title":"Caffeic acid reduces A53T alpha-synuclein by activating JNK\/Bcl-2-mediated autophagy in vitro and improves behaviour and protects dopaminergic neurons in a mouse model of Parkinson's disease","volume":"150","author":"Zhang","year":"2019","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.brainres.2020.147023_b0280","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.lfs.2019.03.047","article-title":"Apelin-36 exerts the cytoprotective effect against MPP(+)-induced cytotoxicity in SH-SY5Y cells through PI3K\/Akt\/mTOR autophagy pathway","volume":"224","author":"Zhu","year":"2019","journal-title":"Life Sci."},{"key":"10.1016\/j.brainres.2020.147023_b0285","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/j.brainres.2019.03.027","article-title":"Apelin-13 protects dopaminergic neurons in MPTP-induced Parkinson's disease model mice through inhibiting endoplasmic reticulum stress and promoting autophagy","volume":"1715","author":"Zhu","year":"2019","journal-title":"Brain Res."},{"key":"10.1016\/j.brainres.2020.147023_b0290","doi-asserted-by":"crossref","DOI":"10.1016\/j.brainres.2019.146334","article-title":"Apelin-36 mitigates MPTP\/MPP(+)-induced neurotoxicity: Involvement of alpha-synuclein and endoplasmic reticulum stress","volume":"1721","author":"Zhu","year":"2019","journal-title":"Brain Res."}],"container-title":["Brain Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006899320303796?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006899320303796?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T12:06:44Z","timestamp":1777378004000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006899320303796"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,11]]},"references-count":57,"alternative-id":["S0006899320303796"],"URL":"https:\/\/doi.org\/10.1016\/j.brainres.2020.147023","relation":{},"ISSN":["0006-8993"],"issn-type":[{"value":"0006-8993","type":"print"}],"subject":[],"published":{"date-parts":[[2020,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Ghrelin protects dopaminergic neurons against MPTP neurotoxicity through promoting autophagy and inhibiting endoplasmic reticulum mediated apoptosis","name":"articletitle","label":"Article Title"},{"value":"Brain Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.brainres.2020.147023","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"147023"}}