{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,28]],"date-time":"2026-06-28T10:49:19Z","timestamp":1782643759388,"version":"3.54.5"},"reference-count":24,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100004924","name":"Guangxi Traditional Chinese Medical University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004924","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Brain Research"],"published-print":{"date-parts":[[2021,1]]},"DOI":"10.1016\/j.brainres.2020.147141","type":"journal-article","created":{"date-parts":[[2020,10,2]],"date-time":"2020-10-02T02:52:57Z","timestamp":1601607177000},"page":"147141","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":17,"special_numbering":"C","title":["Dexmedetomidine inhibits apoptosis of astrocytes induced by oxygen-glucose deprivation via targeting JAK\/STAT3 signal pathway"],"prefix":"10.1016","volume":"1750","author":[{"given":"Pengjiu","family":"Feng","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aimin","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming","family":"Su","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hai","family":"Cai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaogang","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.brainres.2020.147141_b0005","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1016\/j.ntt.2017.01.001","article-title":"Neuroprotection and neurotoxicity in the developing brain: an update on the effects of dexmedetomidine and xenon","volume":"60","author":"Alam","year":"2017","journal-title":"Neurotoxicol. Teratol."},{"key":"10.1016\/j.brainres.2020.147141_b0010","doi-asserted-by":"crossref","first-page":"969","DOI":"10.1038\/jcbfm.2013.44","article-title":"Ionic transporter activity in astrocytes, microglia, and oligodendrocytes during brain ischemia","volume":"33","author":"Annunziato","year":"2013","journal-title":"J. Cereb. Blood Flow Metab."},{"key":"10.1016\/j.brainres.2020.147141_b0015","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1038\/s41467-017-00618-0","article-title":"Tau exacerbates excitotoxic brain damage in an animal model of stroke","volume":"8","author":"Bi","year":"2017","journal-title":"Nat. Commun."},{"key":"10.1016\/j.brainres.2020.147141_b0020","doi-asserted-by":"crossref","first-page":"2787","DOI":"10.2147\/DDDT.S140644","article-title":"Dexmedetomidine reduces the neuronal apoptosis related to cardiopulmonary bypass by inhibiting activation of the JAK2-STAT3 pathway","volume":"11","author":"Chen","year":"2017","journal-title":"Drug Des. Devel. Ther."},{"key":"10.1016\/j.brainres.2020.147141_b0025","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1038\/ki.2015.306","article-title":"Perioperative dexmedetomidine reduces the incidence and severity of acute kidney injury following valvular heart surgery","volume":"89","author":"Cho","year":"2016","journal-title":"Kidney Int."},{"key":"10.1016\/j.brainres.2020.147141_b0030","doi-asserted-by":"crossref","first-page":"e356","DOI":"10.1097\/CCM.0000000000001035","article-title":"Dexmedetomidine attenuates bilirubin-induced lung alveolar epithelial cell death in vitro and in vivo","volume":"43","author":"Cui","year":"2015","journal-title":"Crit. Care Med."},{"key":"10.1016\/j.brainres.2020.147141_b0035","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1186\/s12974-016-0527-5","article-title":"Potential role of microRNA-7 in the anti-neuroinflammation effects of nicorandil in astrocytes induced by oxygen-glucose deprivation","volume":"13","author":"Dong","year":"2016","journal-title":"J. Neuroinflamm."},{"key":"10.1016\/j.brainres.2020.147141_b0040","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1016\/j.ejphar.2019.04.028","article-title":"Tetramethylpyrazine attenuates blood-brain barrier disruption in ischemia\/reperfusion injury through the JAK\/STAT signaling pathway","volume":"854","author":"Gong","year":"2019","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.brainres.2020.147141_b0045","doi-asserted-by":"crossref","first-page":"1019","DOI":"10.1056\/NEJMoa1414905","article-title":"Randomized assessment of rapid endovascular treatment of ischemic stroke","volume":"372","author":"Goyal","year":"2015","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.brainres.2020.147141_b0050","first-page":"119","article-title":"Astrocytes in neurodegenerative diseases (I): function and molecular description","volume":"30","author":"Guillamon-Vivancos","year":"2015","journal-title":"Neurologia"},{"key":"10.1016\/j.brainres.2020.147141_b0055","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1097\/ALN.0000000000002038","article-title":"Dexmedetomidine prevents cognitive decline by enhancing resolution of high mobility group box 1 protein-induced inflammation through a vagomimetic action in mice","volume":"128","author":"Hu","year":"2018","journal-title":"Anesthesiology"},{"key":"10.1016\/j.brainres.2020.147141_b0060","first-page":"5040","article-title":"Dexmedetomidine alleviates LPS-induced septic cardiomyopathy via the cholinergic anti-inflammatory pathway in mice","volume":"9","author":"Kong","year":"2017","journal-title":"Am. J. Transl. Res."},{"key":"10.1016\/j.brainres.2020.147141_b0065","doi-asserted-by":"crossref","DOI":"10.1016\/j.neulet.2020.135047","article-title":"Silencing matrix metalloproteinase 9 exerts a protective effect on astrocytes after oxygen-glucose deprivation and is correlated with suppression of aquaporin-4","volume":"731","author":"Li","year":"2020","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.brainres.2020.147141_b0070","doi-asserted-by":"crossref","first-page":"9494352","DOI":"10.1155\/2020\/9494352","article-title":"Reactive astrogliosis: implications in spinal cord injury progression and therapy","volume":"2020","author":"Li","year":"2020","journal-title":"Oxid. Med. Cell Longev."},{"key":"10.1016\/j.brainres.2020.147141_b0075","first-page":"6352159","article-title":"Dexmedetomidine attenuates lipopolysaccharide induced MCP-1 expression in primary astrocyte","volume":"2017","author":"Liu","year":"2017","journal-title":"Biomed. Res. Int."},{"key":"10.1016\/j.brainres.2020.147141_b0080","doi-asserted-by":"crossref","first-page":"197","DOI":"10.3389\/fncel.2017.00197","article-title":"Dexmedetomidine protects mouse brain from ischemia-reperfusion injury via inhibiting neuronal autophagy through up-regulating HIF-1alpha","volume":"11","author":"Luo","year":"2017","journal-title":"Front. Cell. Neurosci."},{"key":"10.1016\/j.brainres.2020.147141_b0085","doi-asserted-by":"crossref","first-page":"946","DOI":"10.1111\/1440-1681.12791","article-title":"Dexmedetomidine protects mice against myocardium ischaemic\/reperfusion injury by activating an AMPK\/PI3K\/Akt\/eNOS pathway","volume":"44","author":"Sun","year":"2017","journal-title":"Clin. Exp. Pharmacol. Physiol."},{"key":"10.1016\/j.brainres.2020.147141_b0090","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1038\/s41419-019-1416-5","article-title":"Dexmedetomidine inhibits astrocyte pyroptosis and subsequently protects the brain in in vitro and in vivo models of sepsis","volume":"10","author":"Sun","year":"2019","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.brainres.2020.147141_b0095","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/j.neuroscience.2020.06.041","article-title":"Lactate promotes reactive astrogliosis and confers axon guidance potential to astrocytes under oxygen-glucose deprivation","volume":"442","author":"Xu","year":"2020","journal-title":"Neuroscience"},{"key":"10.1016\/j.brainres.2020.147141_b0100","doi-asserted-by":"crossref","DOI":"10.3390\/ijms20236086","article-title":"Ginsenosides Rb1 and Rg1 protect primary cultured astrocytes against oxygen-glucose deprivation\/reoxygenation-induced injury via improving mitochondrial function","volume":"20","author":"Xu","year":"2019","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.brainres.2020.147141_b0105","doi-asserted-by":"crossref","first-page":"2277","DOI":"10.1002\/jcb.29450","article-title":"Dexmedetomidine alleviates neuropathic pain by regulating JAK\/STAT pathway in rats","volume":"121","author":"Xun","year":"2020","journal-title":"J. Cell. Biochem."},{"key":"10.1016\/j.brainres.2020.147141_b0110","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1016\/j.expneurol.2018.07.007","article-title":"Inhibiting Jumoji domain containing protein 3 (JMJD3) prevent neuronal apoptosis from stroke","volume":"308","author":"Zhang","year":"2018","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.brainres.2020.147141_b0115","doi-asserted-by":"crossref","first-page":"1362","DOI":"10.1016\/j.biopha.2018.04.150","article-title":"Taurine enhances the protective effect of Dexmedetomidine on sepsis-induced acute lung injury via balancing the immunological system","volume":"103","author":"Zhao","year":"2018","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.brainres.2020.147141_b0120","article-title":"Dexmedetomidine protects against oxygen-glucose deprivation-induced injury through inducing astrocytes autophagy via TSC2\/mTOR pathway","author":"Zhu","year":"2019","journal-title":"Neuromol. Med."}],"container-title":["Brain Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006899320304996?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006899320304996?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,13]],"date-time":"2025-09-13T18:11:09Z","timestamp":1757787069000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006899320304996"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,1]]},"references-count":24,"alternative-id":["S0006899320304996"],"URL":"https:\/\/doi.org\/10.1016\/j.brainres.2020.147141","relation":{},"ISSN":["0006-8993"],"issn-type":[{"value":"0006-8993","type":"print"}],"subject":[],"published":{"date-parts":[[2021,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Dexmedetomidine inhibits apoptosis of astrocytes induced by oxygen-glucose deprivation via targeting JAK\/STAT3 signal pathway","name":"articletitle","label":"Article Title"},{"value":"Brain Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.brainres.2020.147141","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"147141"}}