{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,16]],"date-time":"2025-09-16T19:12:27Z","timestamp":1758049947432,"version":"3.44.0"},"reference-count":90,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,12,1]],"date-time":"2020-12-01T00:00:00Z","timestamp":1606780800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,12,1]],"date-time":"2020-12-01T00:00:00Z","timestamp":1606780800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,10,13]],"date-time":"2021-10-13T00:00:00Z","timestamp":1634083200000},"content-version":"vor","delay-in-days":316,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Brain Research"],"published-print":{"date-parts":[[2020,12]]},"DOI":"10.1016\/j.brainres.2020.147145","type":"journal-article","created":{"date-parts":[[2020,10,6]],"date-time":"2020-10-06T11:03:55Z","timestamp":1601982235000},"page":"147145","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"special_numbering":"C","title":["Sustained glial reactivity induced by glutaric acid may be the trigger to learning delay in early and late phases of development: Involvement of p75NTR receptor and protection by N-acetylcysteine"],"prefix":"10.1016","volume":"1749","author":[{"given":"Fernanda Silva","family":"Rodrigues","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Angela Patr\u00edcia","family":"Fran\u00e7a","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N\u00fabia","family":"Broetto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ana Fl\u00e1via","family":"Furian","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mauro Schneider","family":"Oliveira","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adair Roberto Soares","family":"Santos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luiz Fernando Freire","family":"Royes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michele Rechia","family":"Fighera","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.brainres.2020.147145_b0005","doi-asserted-by":"crossref","first-page":"1515","DOI":"10.1212\/WNL.57.8.1515","article-title":"Controlled trial of N-acetylcysteine for patients with probable Alzheimer\u2019s disease","volume":"57","author":"Adair","year":"2011","journal-title":"Neurology"},{"key":"10.1016\/j.brainres.2020.147145_b0010","doi-asserted-by":"crossref","DOI":"10.1016\/j.neuint.2019.104467","article-title":"Acute lysine overload provokes marked striatum injury involving oxidative stress signaling pathways in glutaryl-CoA dehydrogenase deficient mice","volume":"129","author":"Amaral","year":"2019","journal-title":"Neurochem. Int."},{"key":"10.1016\/j.brainres.2020.147145_b0015","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1002\/hipo.20598","article-title":"Enhanced spatial memory and hippocampal long-term potentiation in p75 neurotrophin receptor knockout mice","volume":"20","author":"Barrett","year":"2010","journal-title":"Hippocampus."},{"key":"10.1016\/j.brainres.2020.147145_b0020","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1007\/s10545-009-1167-z","article-title":"Cognitive, behavioral and adaptive profiles of children with glutaric aciduria type I detected through newborn screening","volume":"32","author":"Beauchamp","year":"2009","journal-title":"J. Metabol. Dis."},{"key":"10.1016\/j.brainres.2020.147145_b0025","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/j.ymgme.2008.02.010","article-title":"Clinical, ethical and legal considerations in the treatment of newborns with non-ketotic hyperglycinaemia","volume":"94","author":"Boneh","year":"2008","journal-title":"Mol. Genet. Metabol."},{"issue":"1","key":"10.1016\/j.brainres.2020.147145_b0030","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1007\/s10545-016-9999-9","article-title":"Proposed Recommendations for Diagnosing and Managing Individuals With Glutaric Aciduria Type I: Second Revision","volume":"40","author":"Boy","year":"2017","journal-title":"J. Inherit. Metab. Dis."},{"key":"10.1016\/j.brainres.2020.147145_b0035","first-page":"1","article-title":"A cross-sectional controlled developmental study of neuropsychological functions in patients with glutaric aciduria type I","volume":"163","author":"Boy","year":"2015","journal-title":"Orphanet J. Rare Dis."},{"key":"10.1016\/j.brainres.2020.147145_b0040","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1016\/0003-2697(76)90527-3","article-title":"A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding","volume":"72","author":"Bradford","year":"1976","journal-title":"Anal. Biochem."},{"key":"10.1016\/j.brainres.2020.147145_b0045","doi-asserted-by":"crossref","first-page":"911","DOI":"10.1023\/B:BOLI.0000045776.50573.52","article-title":"Management of movement disorders in glutaryl-CoA dehydrogenase deficiency: anticholinergic drugs and botulinum toxin as additional therapeutic options","volume":"27","author":"Burlina","year":"2004","journal-title":"J. Inherit. Metab. Dis."},{"key":"10.1016\/j.brainres.2020.147145_b0050","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1016\/j.freeradbiomed.2016.10.497","article-title":"4-Hydroxynonenal (HNE) modified proteins in metabolic diseases","volume":"111","author":"Castro","year":"2017","journal-title":"Free Radic. Biol. Med."},{"issue":"22","key":"10.1016\/j.brainres.2020.147145_b0055","doi-asserted-by":"crossref","first-page":"9280","DOI":"10.1073\/pnas.1016190108","article-title":"Changes in striatal procedural memory coding correlate with learning deficits in a mouse model of Huntington disease","volume":"108","author":"Cayzac","year":"2011","journal-title":"Proceed. Natl. Acad. Sci. U.S."},{"issue":"4","key":"10.1016\/j.brainres.2020.147145_b0060","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1177\/0269881118822157","article-title":"Effect of N-methyl-D-aspartate-receptor-enhancing agents on cognition in patients with schizophrenia: A systematic review and meta-analysis of double-blind randomised controlled trials","volume":"33","author":"Chang","year":"2019","journal-title":"J. Psychopharmacol."},{"issue":"4","key":"10.1016\/j.brainres.2020.147145_b0065","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0092325","article-title":"Human Astrocytes: Secretome Profiles of Cytokines and Chemokines","volume":"9","author":"Choi","year":"2014","journal-title":"PLoS ONE"},{"key":"10.1016\/j.brainres.2020.147145_b0070","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1016\/j.conb.2011.10.003","article-title":"The role of glial cells in synapse elimination","volume":"22","author":"Chung","year":"2013","journal-title":"Curr. Opin. Neurobiol."},{"issue":"1","key":"10.1016\/j.brainres.2020.147145_b0075","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/S1385-299X(99)00062-8","article-title":"Technique for collecting cerebrospinal fluid in the cisterna magna of non-anesthetized rats","volume":"5","author":"Consiglio","year":"2000","journal-title":"Brain Res Brain Res. Protoc."},{"key":"10.1016\/j.brainres.2020.147145_b0080","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.cbi.2016.04.026","article-title":"N-acetylcysteine protects memory decline induced by streptozotocin in mice","volume":"253","author":"Costa","year":"2016","journal-title":"Chem. Biol. Interact."},{"key":"10.1016\/j.brainres.2020.147145_b0085","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1016\/S0079-6123(08)62117-2","article-title":"Effects of trophic factors on the CNS cholinergic phenotype","volume":"109","author":"Cuello","year":"1996","journal-title":"Prog. Brain Res."},{"key":"10.1016\/j.brainres.2020.147145_b0090","doi-asserted-by":"crossref","first-page":"4067","DOI":"10.1073\/pnas.96.7.4067","article-title":"A nerve growth factor mimetic TrkA antagonist causes withdrawal of cortical cholinergic boutons in the adult rat","volume":"96","author":"Debeir","year":"1999","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1016\/j.brainres.2020.147145_b0095","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1503\/jpn.100057","article-title":"N-acetylcysteine in psychiatry: current therapeutic evidence and potential mechanisms of action","volume":"36","author":"Dean","year":"2011","journal-title":"J. Psychiatry Neurosci."},{"key":"10.1016\/j.brainres.2020.147145_b0100","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1111\/j.1440-1819.2012.02392.x","article-title":"Effects of N-acetyl cysteine on cognitive function in bipolar disorder","volume":"66","author":"Dean","year":"2012","journal-title":"Psychiatry Clin. Neurosci."},{"key":"10.1016\/j.brainres.2020.147145_b0105","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1016\/j.neubiorev.2015.04.015","article-title":"Clinical trials of N-acetylcysteine in psychiatry and neurology: A systematic review","volume":"55","author":"Deepmala,","year":"2015","journal-title":"Neurosci. Biobehav. Rev."},{"key":"10.1016\/j.brainres.2020.147145_b0110","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1006\/nlme.1996.0072","article-title":"Dissociation of hippocampal and striatal contributions to spatial navigation in the water maze","volume":"66","author":"Devan","year":"1996","journal-title":"Neurobiol. Learn. Mem."},{"key":"10.1016\/j.brainres.2020.147145_b0115","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/j.mcn.2006.11.005","article-title":"Pro-NGF secreted by astrocytes promotes motor neuron cell death","volume":"34","author":"Domeniconi","year":"2007","journal-title":"Mol. Cell. Neurosci."},{"key":"10.1016\/j.brainres.2020.147145_b0120","doi-asserted-by":"crossref","first-page":"90617","DOI":"10.1371\/journal.pone.0090617","article-title":"Efficacy of N-Acetyl Cysteine in Traumatic Brain Injury","volume":"9","author":"Eakin","year":"2014","journal-title":"PLoS ONE"},{"key":"10.1016\/j.brainres.2020.147145_b0125","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1016\/j.nbd.2006.01.002","article-title":"GM1 ganglioside prevents seizures, Na+, K+-ATPase activity inhibition and oxidative stress induced by glutaric acid and pentylenetetrazole","volume":"22","author":"Fighera","year":"2006","journal-title":"Neurobiol. Dis."},{"issue":"6","key":"10.1016\/j.brainres.2020.147145_b0130","first-page":"1","article-title":"Multiple Functions of the p75 Neurotrophin Receptor in the Nervous System","volume":"14","author":"Firouzi","year":"2012","journal-title":"Zahedan J. Res. Med. Sci."},{"key":"10.1016\/j.brainres.2020.147145_b0135","unstructured":"Fuster JM (2003) Cortex and Mind: Unifying Cognition. New York: Oxford."},{"key":"10.1016\/j.brainres.2020.147145_b0140","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1093\/jnen\/nlw121","article-title":"Methylmalonate Induces Inflammatory and Apoptotic Potential: A Link to Glial Activation and Neurological Dysfunction","volume":"76","author":"Gabbi","year":"2017","journal-title":"J. Neuropathol. Exp. Neurol."},{"key":"10.1016\/j.brainres.2020.147145_b0145","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/j.toxlet.2018.06.1070","article-title":"Ammonia role in glial dysfunction in methylmalonic acidemia","volume":"295","author":"Gabbi","year":"2018","journal-title":"Toxicol. Lett."},{"key":"10.1016\/j.brainres.2020.147145_b0150","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1146\/annurev.psych.49.1.87","article-title":"Cognitive neuroscience of human memory","volume":"49","author":"Gabrieli","year":"1998","journal-title":"Annu. Rev. Psychol."},{"key":"10.1016\/j.brainres.2020.147145_b0155","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1124\/mol.117.109926","article-title":"N-Acetyl-l-Cysteine Protects Astrocytes against Proteotoxicity without Recourse to Glutathione","volume":"92","author":"Gleixner","year":"2017","journal-title":"Mol. Pharmacol."},{"key":"10.1016\/j.brainres.2020.147145_b0160","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1111\/j.1471-4159.2009.06296.x","article-title":"PolyADP-ribosylation is required for long-term memory formation in mammals","volume":"111","author":"Goldberg","year":"2009","journal-title":"J. Neurochem."},{"key":"10.1016\/j.brainres.2020.147145_b0165","doi-asserted-by":"crossref","first-page":"746","DOI":"10.1016\/S0022-3476(77)81240-7","article-title":"Glutaric aciduria: biochemical and morphologic considerations","volume":"90","author":"Goodman","year":"1977","journal-title":"J. Pediatr."},{"key":"10.1016\/j.brainres.2020.147145_b0170","series-title":"The Metabolic and Molecular Bases of Inherited Disease","first-page":"2195","article-title":"Organic acidemias due to defects in lysine oxidation: 2-ketoadipic acidemia and glutaric acidemia","author":"Goodman","year":"2001"},{"key":"10.1016\/j.brainres.2020.147145_b0175","first-page":"2420","article-title":"(2019) l-Carnitine prevents oxidative stress in striatum of glutaryl-CoA dehydrogenase deficient mice submitted to lysine overload","volume":"9","author":"Guerreiro","year":"1865","journal-title":"Biochim. Biophys. Acta, Mol. Basis Dis."},{"key":"10.1016\/j.brainres.2020.147145_b0180","doi-asserted-by":"crossref","first-page":"969","DOI":"10.1016\/j.biopsych.2011.09.031","article-title":"Glutamatergic modulation of auditory information processing in the human brain","volume":"71","author":"Gunduz-Bruce","year":"2012","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.brainres.2020.147145_b0185","doi-asserted-by":"crossref","first-page":"1764","DOI":"10.1093\/brain\/awp112","article-title":"Dynamic changes of striatal and extrastriatal abnormalities in glutaric aciduria type I","volume":"132","author":"Harting","year":"2009","journal-title":"Brain"},{"key":"10.1016\/j.brainres.2020.147145_b0190","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1016\/j.bbr.2010.11.047","article-title":"The cholinergic system and neostriatal memory functions","volume":"221","author":"Havekes","year":"2011","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.brainres.2020.147145_b0195","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1007\/BF00711759","article-title":"Early signs and course of disease of glutaryl-CoA dehydrogenase deficiency","volume":"18","author":"Hoffmann","year":"1995","journal-title":"J. Inherit. Metab. Dis."},{"key":"10.1016\/j.brainres.2020.147145_b0200","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1055\/s-2007-973761","article-title":"Clinical course, early diagnosis, treatment, and prevention of disease in glutaryl-CoA dehydrogenase deficiency","volume":"27","author":"Hoffmann","year":"1996","journal-title":"Neuropediatrics."},{"key":"10.1016\/j.brainres.2020.147145_b0205","series-title":"In: Neurobiology of the Neurotrophins","first-page":"255","article-title":"Nerve growth factor effects on cholinergic modulation of hippocampal and cortical plasticity","author":"Howe","year":"2001"},{"key":"10.1016\/j.brainres.2020.147145_b0210","doi-asserted-by":"crossref","first-page":"33412","DOI":"10.1074\/jbc.M706799200","article-title":"Heat Shock Factor 1 Attenuates 4-Hydroxynonenal-mediated Apoptosis","volume":"282","author":"Jacobs","year":"2007","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.brainres.2020.147145_b0215","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1016\/j.parkreldis.2015.02.020","article-title":"Cerebrospinal fluid concentrations of N-acetylcysteine after oral administration in Parkinson's disease","volume":"21","author":"Katz","year":"2015","journal-title":"Parkinsonism Relat. Disord."},{"key":"10.1016\/j.brainres.2020.147145_b0220","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1016\/j.nlm.2011.02.010","article-title":"The effects of binge MDMA on acquisition and reversal learning in a radial-arm maze task","volume":"95","author":"Kay","year":"2010","journal-title":"Neurobiol. Learn. Mem."},{"key":"10.1016\/j.brainres.2020.147145_b0225","doi-asserted-by":"crossref","first-page":"325","DOI":"10.5607\/en.2015.24.4.325","article-title":"The Role of Oxidative Stress in Neurodegenerative Diseases","volume":"4","author":"Kim","year":"2015","journal-title":"Exp. Neurobiol."},{"key":"10.1016\/j.brainres.2020.147145_b0230","doi-asserted-by":"crossref","first-page":"1969","DOI":"10.2466\/pms.1969.29.2.550","article-title":"Caudate nucleus lesions impair spontaneous alternation","volume":"29","author":"Kirkby","year":"1969","journal-title":"Percept. Mot. Skills"},{"key":"10.1016\/j.brainres.2020.147145_b0235","doi-asserted-by":"crossref","first-page":"590","DOI":"10.3390\/ijerph8020590","article-title":"Early Postnatal Protein-Calorie Malnutrition and Cognition: A Review of Human and Animal Studies","volume":"8","author":"Laus","year":"2011","journal-title":"Int. J. Environ. Res. Public Health"},{"key":"10.1016\/j.brainres.2020.147145_b0240","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.exger.2016.05.006","article-title":"A diphenyl diselenide-supplemented diet and swimming exercise promote neuroprotection, reduced cell apoptosis and glial cell activation in the hypothalamus of old rats","volume":"82","author":"Leite","year":"2016","journal-title":"Exp. Gerontol."},{"key":"10.1016\/j.brainres.2020.147145_b0245","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1242\/jcs.113.4.635","article-title":"4-hydroxynonenal induces a cellular redox status-related activation of the caspase cascade for apoptotic cell death","volume":"113","author":"Liu","year":"2000","journal-title":"J. Cell Sci."},{"key":"10.1016\/j.brainres.2020.147145_b0250","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1016\/j.freeradbiomed.2016.11.046","article-title":"Cisplatin-induced mitochondrial dysfunction is associated with impaired cognitive function in rats","volume":"102","author":"Lomeli","year":"2017","journal-title":"Free Radical Biol. Med."},{"issue":"7","key":"10.1016\/j.brainres.2020.147145_b0255","doi-asserted-by":"crossref","first-page":"951","DOI":"10.1016\/j.neuropharm.2010.01.008","article-title":"Neurotransmitter Roles in Synaptic Modulation, Plasticity and Learning in the Dorsal Striatum","volume":"58","author":"Lovinger","year":"2010","journal-title":"Neuropharmacology"},{"issue":"5","key":"10.1016\/j.brainres.2020.147145_b0260","first-page":"4097","article-title":"Sevoflurane-induced memory impairment in the postnatal developing mouse brain","volume":"15","author":"Lu","year":"2018","journal-title":"Exp Ther Med."},{"key":"10.1016\/j.brainres.2020.147145_b0265","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.ijdevneu.2008.09.004","article-title":"Kinetic characterization of l-[(3)H]glutamate uptake inhibition and increase oxidative damage induced by glutaric acid in striatal synaptosomes of rats","volume":"7","author":"Magni","year":"2009","journal-title":"Int. J. Dev. Neurosci."},{"issue":"9","key":"10.1016\/j.brainres.2020.147145_b0270","doi-asserted-by":"crossref","first-page":"1723","DOI":"10.1002\/jnr.23070","article-title":"m-Trifluoromethyl Diphenyl Diselenide Attenuates Glutaric Acid-Induced Seizures and Oxidative Stress in Rat Pups: Involvement of the c-Aminobutyric Acidergic System","volume":"90","author":"Magni","year":"2012","journal-title":"J. Neurosci. Res."},{"key":"10.1016\/j.brainres.2020.147145_b0275","doi-asserted-by":"crossref","unstructured":"Marques FO, et al. (2003) Glutaric acid induces oxidative stress in brain of young rats. Brain Research. 964, 153-158. Doi: 10.1016\/s0006-8993(02)04118-5.","DOI":"10.1016\/S0006-8993(02)04118-5"},{"key":"10.1016\/j.brainres.2020.147145_b0280","doi-asserted-by":"crossref","unstructured":"Matthews BR (2015) Memory Dysfunction. Continuum (Minneap Minn), (3 Behavioral Neurology and Neuropsychiatry), 613-26. Doi: 10.1212\/01.CON.0000466656.59413.29.","DOI":"10.1212\/01.CON.0000466656.59413.29"},{"key":"10.1016\/j.brainres.2020.147145_b0285","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/S0361-9230(02)00754-2","article-title":"Impaired learning in a spatial working memory version and in a cued version of the water maze in rats with MPTP-induced mesencephalic dopaminergic lesions","volume":"58","author":"Miyoshi","year":"2002","journal-title":"Brain Res. Bull."},{"issue":"6","key":"10.1016\/j.brainres.2020.147145_b0290","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0157602","article-title":"N-Acetyl Cysteine May Support Dopamine Neurons in Parkinson's Disease: Preliminary Clinical and Cell Line Data","volume":"11","author":"Monti","year":"2016","journal-title":"PLoS ONE"},{"key":"10.1016\/j.brainres.2020.147145_b0295","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.nlm.2013.07.002","article-title":"Microglia: A new frontier for synaptic plasticity, learning and memory, and neurodegenerative disease research","volume":"105","author":"Morris","year":"2013","journal-title":"Neurobiol. Learn. Mem."},{"key":"10.1016\/j.brainres.2020.147145_b0300","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1038\/297681a0","article-title":"Place navigation impaired in rats with hippocampal lesions","volume":"297","author":"Morris","year":"1982","journal-title":"Nature"},{"key":"10.1016\/j.brainres.2020.147145_b0305","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1002\/ajmg.1320410122","article-title":"Glutaric aciduria type I: a common cause of episodic encephalopathy and spastic paralysis in the Amish of Lancaster County, Pennsylvania","volume":"41","author":"Morton","year":"1991","journal-title":"Am. J. Med. Genet."},{"issue":"5","key":"10.1016\/j.brainres.2020.147145_b0310","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1515\/revneuro-2015-0070","article-title":"Interrelations between cognitive dysfunction and motor symptoms of Parkinson\u2019s disease: behavioral and neural studies","volume":"27","author":"Moustafa","year":"2016","journal-title":"Rev. Neurosci."},{"key":"10.1016\/j.brainres.2020.147145_b0315","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1016\/j.bbr.2010.02.024","article-title":"The cholinergic system, nerve growth factor and the cytoskeleton","volume":"221","author":"Niewiadomska","year":"2011","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.brainres.2020.147145_b0320","doi-asserted-by":"crossref","first-page":"528","DOI":"10.1016\/j.nbd.2008.09.011","article-title":"Astrocytic proliferation and mitochondrial dysfunction induced by accumulated glutaric acidemia I (GAI) metabolites: possible implications for GAI pathogenesis","volume":"32","author":"Olivera-Bravo","year":"2008","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.brainres.2020.147145_b0325","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0020831","article-title":"Neonatal astrocyte damage is sufficient to trigger progressive striatal degeneration in a rat model of glutaric acidemia-I","volume":"6","author":"Olivera-Bravo","year":"2011","journal-title":"PLoS ONE"},{"issue":"22","key":"10.1016\/j.brainres.2020.147145_b0330","doi-asserted-by":"crossref","first-page":"3492","DOI":"10.1016\/j.febslet.2015.09.010","article-title":"A role of astrocytes in mediating postnatal neurodegeneration in Glutaric acidemia-type 1","volume":"589","author":"Olivera-Bravo","year":"2015","journal-title":"FEBS Lett."},{"issue":"6","key":"10.1016\/j.brainres.2020.147145_b0335","doi-asserted-by":"crossref","first-page":"4504","DOI":"10.1093\/hmg\/ddv175","article-title":"Striatal neuronal death mediated by astrocytes from the Gcdh\u2212\/\u2212 mouse model of glutaric acidemia type I","volume":"24","author":"Olivera-Bravo","year":"2015","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.brainres.2020.147145_b0340","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1007\/978-3-319-40764-7_11","article-title":"Astrocyte Dysfunction in Developmental Neurometabolic Diseases","volume":"949","author":"Olivera-Bravo","year":"2016","journal-title":"Adv. Exp. Med. Biol."},{"key":"10.1016\/j.brainres.2020.147145_b0345","first-page":"948","article-title":"Glutaric aciduria type I associated with learning disability","volume":"71","author":"Patil","year":"2004","journal-title":"Indian J. Pediatr."},{"issue":"6","key":"10.1016\/j.brainres.2020.147145_b0350","first-page":"1","article-title":"Early malnutrition results in longlasting impairments in pattern separation for overlapping novel object and novel location memories and reduced hippocampal neurogenesis","volume":"17","author":"P\u00e9rez-Garc\u00eda","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.brainres.2020.147145_b0355","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1111\/j.1749-6632.2002.tb02086.x","article-title":"The role of apoptosis in the normal aging brain, skeletal muscle, and heart","volume":"959","author":"Pollack","year":"2002","journal-title":"Ann. N. Y. Acad. Sci."},{"issue":"2","key":"10.1016\/j.brainres.2020.147145_b0360","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1016\/j.expneurol.2006.07.001","article-title":"The risk is in the air: Intranasal administration of MPTP to rats reproducing clinical features of Parkinson's disease","volume":"202","author":"Prediger","year":"2006","journal-title":"Exp. Neurol."},{"issue":"10","key":"10.1016\/j.brainres.2020.147145_b0365","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0078332","article-title":"N-acetylcysteine prevents spatial memory impairment induced by chronic early postnatal glutaric acid and lipopolysaccharide in rat pups","volume":"8","author":"Rodrigues","year":"2013","journal-title":"PLoS ONE"},{"issue":"7","key":"10.1016\/j.brainres.2020.147145_b0370","doi-asserted-by":"crossref","first-page":"4945","DOI":"10.1007\/s12035-018-1395-z","article-title":"Involvement of the cholinergic parameters and glial cells in learning delay induced by glutaric acid: Protection by N-Acetylcysteine","volume":"56","author":"Rodrigues","year":"2019","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.brainres.2020.147145_b0375","doi-asserted-by":"crossref","first-page":"1018","DOI":"10.1038\/nm.4397","article-title":"Microglia emerge as central players in brain disease","volume":"23","author":"Salter","year":"2017","journal-title":"Nat. Med."},{"key":"10.1016\/j.brainres.2020.147145_b0380","first-page":"4117","article-title":"The chemistry and biological activities of N-acetylcysteine","volume":"8","author":"Samuni","year":"2013","journal-title":"BBA"},{"key":"10.1016\/j.brainres.2020.147145_b0385","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1016\/0959-4388(95)80025-5","article-title":"Neurobiology of skill and habit learning","volume":"5","author":"Salmon","year":"1995","journal-title":"Curr. Opin. Neurobiol."},{"issue":"10","key":"10.1016\/j.brainres.2020.147145_b0390","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a020545","article-title":"Microglia Function in Central Nervous System Development and Plasticity","volume":"7","author":"Schafer","year":"2015","journal-title":"Cold Spring Harb. Perspect. Biol."},{"issue":"287","key":"10.1016\/j.brainres.2020.147145_b0395","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.pscychresns.2019.03.011","article-title":"The effect of N-acetylcysteine and working memory training on neural mechanisms of working memory and cue reactivity in regular cocaine users","volume":"30","author":"Schulte","year":"2019","journal-title":"Psychiat. Res. Neuroimag."},{"key":"10.1016\/j.brainres.2020.147145_b0400","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.ymgme.2012.03.002","article-title":"Induction of oxidative stress in brain of glutaryl-CoA dehydrogenase deficient mice by acute lysine administration","volume":"106","author":"Seminotti","year":"2012","journal-title":"Mol. Genet. Metab."},{"key":"10.1016\/j.brainres.2020.147145_b0405","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1016\/j.neuron.2010.02.014","article-title":"A Possible Role for the Striatum in the Pathogenesis of the Cognitive Symptoms of Schizophrenia","volume":"65","author":"Simpson","year":"2010","journal-title":"Neuron"},{"key":"10.1016\/j.brainres.2020.147145_b0410","doi-asserted-by":"crossref","first-page":"1217","DOI":"10.1146\/annurev.neuro.24.1.1217","article-title":"Nerve growth factor signaling, neuroprotection, and neural repair","volume":"24","author":"Sofroniew","year":"2001","journal-title":"Annu. Rev. Neurosci."},{"issue":"6","key":"10.1016\/j.brainres.2020.147145_b0415","doi-asserted-by":"crossref","first-page":"2491","DOI":"10.1007\/s00726-012-1329-4","article-title":"Involvement of hippocampal CAMKII\/CREB signaling in the spatial memory retention induced by creatine","volume":"43","author":"Souza","year":"2012","journal-title":"Amino Acids"},{"key":"10.1016\/j.brainres.2020.147145_b0420","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1002\/ajmg.c.20008","article-title":"Type I glutaric aciduria. Part 2. A model of acute striatal necrosis","volume":"121","author":"Strauss","year":"2003","journal-title":"Am. J. Med. Genet. C Semin. Med. Genet."},{"key":"10.1016\/j.brainres.2020.147145_b0425","doi-asserted-by":"crossref","first-page":"1268","DOI":"10.1002\/bies.20164","article-title":"PolyADP-ribose polymerase-1 (PARP-1) and the evolution of learning and memory","volume":"26","author":"Sung","year":"2004","journal-title":"BioEssays"},{"key":"10.1016\/j.brainres.2020.147145_b0430","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3390\/ijms18030504","article-title":"The Diverse Roles of Microglia in the Neurodegenerative Aspects of Central Nervous System (CNS) Autoimmunity","volume":"18","author":"Thompson","year":"2017","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.brainres.2020.147145_b0435","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/j.ijdevneu.2019.05.005","article-title":"Pathogenesis of brain damage in glutaric acidemia type I: Lessons from the genetic mice model","volume":"78","author":"Wajner","year":"2019","journal-title":"Int. J. Dev. Neurosci."},{"key":"10.1016\/j.brainres.2020.147145_b0440","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1038\/s41582-019-0161-9","article-title":"Neurological manifestations of organic acidurias","volume":"15","author":"Wajner","year":"2019","journal-title":"Nat Rev Neurol."},{"issue":"7","key":"10.1016\/j.brainres.2020.147145_b0445","doi-asserted-by":"crossref","first-page":"5491","DOI":"10.1002\/jcb.26712","article-title":"Pretreatment of glial cell-derived neurotrophic factor and geranylgeranylacetone ameliorates brain injury in Parkinson's disease by its anti-apoptotic and anti-oxidative property","volume":"119","author":"Yue","year":"2018","journal-title":"J. Cell. Biochem."},{"issue":"4","key":"10.1016\/j.brainres.2020.147145_b0450","doi-asserted-by":"crossref","first-page":"899","DOI":"10.1093\/brain\/awl009","article-title":"A diet-induced mouse model for glutaric aciduria type I","volume":"129","author":"Zinnanti","year":"2006","journal-title":"Brain."}],"container-title":["Brain Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006899320305035?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006899320305035?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,13]],"date-time":"2025-09-13T18:14:00Z","timestamp":1757787240000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006899320305035"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,12]]},"references-count":90,"alternative-id":["S0006899320305035"],"URL":"https:\/\/doi.org\/10.1016\/j.brainres.2020.147145","relation":{},"ISSN":["0006-8993"],"issn-type":[{"type":"print","value":"0006-8993"}],"subject":[],"published":{"date-parts":[[2020,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Sustained glial reactivity induced by glutaric acid may be the trigger to learning delay in early and late phases of development: Involvement of p75NTR receptor and protection by N-acetylcysteine","name":"articletitle","label":"Article Title"},{"value":"Brain Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.brainres.2020.147145","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"147145"}}