{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,16]],"date-time":"2025-09-16T19:12:06Z","timestamp":1758049926447,"version":"3.44.0"},"reference-count":40,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,7,1]],"date-time":"2021-07-01T00:00:00Z","timestamp":1625097600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,7,1]],"date-time":"2021-07-01T00:00:00Z","timestamp":1625097600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,7,1]],"date-time":"2021-07-01T00:00:00Z","timestamp":1625097600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2021,7,1]],"date-time":"2021-07-01T00:00:00Z","timestamp":1625097600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2021,7,1]],"date-time":"2021-07-01T00:00:00Z","timestamp":1625097600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2021,7,1]],"date-time":"2021-07-01T00:00:00Z","timestamp":1625097600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2021,7,1]],"date-time":"2021-07-01T00:00:00Z","timestamp":1625097600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Brain Research"],"published-print":{"date-parts":[[2021,7]]},"DOI":"10.1016\/j.brainres.2021.147348","type":"journal-article","created":{"date-parts":[[2021,2,9]],"date-time":"2021-02-09T09:19:52Z","timestamp":1612862392000},"page":"147348","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":6,"special_numbering":"C","title":["Neogenin is highly expressed in diffuse intrinsic pontine glioma and influences tumor invasion"],"prefix":"10.1016","volume":"1762","author":[{"given":"Julie","family":"Sesen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5820-0051","authenticated-orcid":false,"given":"Jessica","family":"Driscoll","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nishali","family":"Shah","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexander","family":"Moses-Gardner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9051-8425","authenticated-orcid":false,"given":"Gabrielle","family":"Luiselli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9246-4184","authenticated-orcid":false,"given":"Sanda","family":"Alexandrescu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3610-6942","authenticated-orcid":false,"given":"David","family":"Zurakowski","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patricia A.","family":"Baxter","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2125-3659","authenticated-orcid":false,"given":"Jack M.","family":"Su","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katie","family":"Pricola Fehnel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Edward R.","family":"Smith","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.brainres.2021.147348_b0005","doi-asserted-by":"crossref","first-page":"3716","DOI":"10.1158\/0008-5472.CAN-13-3116","article-title":"Netrin-1 promotes medulloblastoma cell invasiveness and angiogenesis, and demonstrates elevated expression in tumor tissue and urine of patients with pediatric medulloblastoma","volume":"74","author":"Akino","year":"2014","journal-title":"Cancer Res."},{"issue":"528\u2013544","key":"10.1016\/j.brainres.2021.147348_b0010","article-title":"Re-programing Chromatin with a Bifunctional LSD1\/HDAC Inhibitor Induces Therapeutic Differentiation in DIPG","volume":"36","author":"Anastas","year":"2019","journal-title":"Cancer Cell"},{"key":"10.1016\/j.brainres.2021.147348_b0015","doi-asserted-by":"crossref","first-page":"1068","DOI":"10.1093\/neuonc\/now299","article-title":"The transcription factor Olig2 is important for the biology of diffuse intrinsic pontine gliomas","volume":"19","author":"Anderson","year":"2017","journal-title":"Neuro. Oncol."},{"key":"10.1016\/j.brainres.2021.147348_b0020","doi-asserted-by":"crossref","first-page":"978","DOI":"10.1038\/nrc1504","article-title":"Netrin-1 and its receptors in tumorigenesis","volume":"4","author":"Arakawa","year":"2004","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.brainres.2021.147348_b0025","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1038\/s41419-019-2043-x","article-title":"Exploring specific prognostic biomarkers in triple-negative breast cancer","volume":"10","author":"Bao","year":"2019","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.brainres.2021.147348_b0030","doi-asserted-by":"crossref","first-page":"875","DOI":"10.1093\/neuonc\/noaa016","article-title":"A phase I\/II study of veliparib (ABT-888) with radiation and temozolomide in newly diagnosed diffuse pontine glioma: a Pediatric Brain Tumor Consortium study","volume":"22","author":"Baxter","year":"2020","journal-title":"Neuro. Oncol."},{"key":"10.1016\/j.brainres.2021.147348_b0035","doi-asserted-by":"crossref","first-page":"221","DOI":"10.3389\/fncel.2018.00221","article-title":"Revisiting Netrin-1: One Who Guides (Axons)","volume":"12","author":"Boyer","year":"2018","journal-title":"Front. Cell. Neurosci."},{"key":"10.1016\/j.brainres.2021.147348_b0040","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1016\/j.biocel.2008.03.014","article-title":"Netrin-1: diversity in development","volume":"41","author":"Bradford","year":"2009","journal-title":"Int. J. Biochem. Cell Biol."},{"key":"10.1016\/j.brainres.2021.147348_b0045","doi-asserted-by":"crossref","first-page":"5454","DOI":"10.1038\/s41598-017-05707-0","article-title":"Netrin-1 promotes glioma growth by activating NF-kappaB via UNC5A","volume":"7","author":"Chen","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.brainres.2021.147348_b0050","doi-asserted-by":"crossref","first-page":"1569","DOI":"10.1016\/j.biocel.2006.11.009","article-title":"Neogenin: A multi-functional receptor regulating diverse developmental processes","volume":"39","author":"Cole","year":"2007","journal-title":"Int. J. Biochem. Cell Biol."},{"key":"10.1016\/j.brainres.2021.147348_b0055","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1126\/science.aao4750","article-title":"Developmental and oncogenic programs in H3K27M gliomas dissected by single-cell RNA-seq","volume":"360","author":"Filbin","year":"2018","journal-title":"Science"},{"key":"10.1016\/j.brainres.2021.147348_b0060","doi-asserted-by":"crossref","first-page":"1865","DOI":"10.1038\/onc.2010.13","article-title":"Dependence receptors: a new paradigm in cell signaling and cancer therapy","volume":"29","author":"Goldschneider","year":"2010","journal-title":"Oncogene"},{"key":"10.1016\/j.brainres.2021.147348_b0065","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0037204","article-title":"EGFR soluble isoforms and their transcripts are expressed in meningiomas","volume":"7","author":"Guillaudeau","year":"2012","journal-title":"PLoS ONE"},{"key":"10.1016\/j.brainres.2021.147348_b0070","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1016\/j.clinbiochem.2016.11.033","article-title":"Prognostic value of rare and complex mutations in EGFR and serum levels of soluble EGFR and its ligands in non-small cell lung carcinoma patients","volume":"50","author":"Haghgoo","year":"2017","journal-title":"Clin. Biochem."},{"key":"10.1016\/j.brainres.2021.147348_b0075","doi-asserted-by":"crossref","first-page":"11003","DOI":"10.1523\/JNEUROSCI.3285-08.2008","article-title":"Maintenance of axo-oligodendroglial paranodal junctions requires DCC and netrin-1","volume":"28","author":"Jarjour","year":"2008","journal-title":"J. Neurosci."},{"key":"10.1016\/j.brainres.2021.147348_b0080","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/S0092-8674(00)81336-7","article-title":"Deleted in Colorectal Cancer (DCC) encodes a netrin receptor","volume":"87","author":"Keino-Masu","year":"1996","journal-title":"Cell"},{"key":"10.1016\/j.brainres.2021.147348_b0085","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1007\/s00401-012-0998-0","article-title":"K27M mutation in histone H3.3 defines clinically and biologically distinct subgroups of pediatric diffuse intrinsic pontine gliomas","volume":"124","author":"Khuong-Quang","year":"2012","journal-title":"Acta Neuropathol."},{"key":"10.1016\/j.brainres.2021.147348_b0090","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1038\/nature02788","article-title":"Netrin-1 controls colorectal tumorigenesis by regulating apoptosis","volume":"431","author":"Laetitia Mazelin","year":"2004","journal-title":"Nature"},{"key":"10.1016\/j.brainres.2021.147348_b0095","doi-asserted-by":"crossref","first-page":"2153","DOI":"10.1242\/dev.044529","article-title":"Netrins: versatile extracellular cues with diverse functions","volume":"138","author":"Lai Wing Sun","year":"2011","journal-title":"Development."},{"key":"10.1016\/j.brainres.2021.147348_b0100","doi-asserted-by":"crossref","first-page":"e113","DOI":"10.1016\/j.clbc.2019.08.010","article-title":"MicroRNA-4472 Promotes Tumor Proliferation and Aggressiveness in Breast Cancer by Targeting RGMA and Inducing EMT","volume":"20","author":"Li","year":"2020","journal-title":"Clin Breast Cancer."},{"key":"10.1016\/j.brainres.2021.147348_b0105","doi-asserted-by":"crossref","first-page":"200","DOI":"10.3390\/brainsci8110200","article-title":"Intersection of Brain Development and Paediatric Diffuse Midline Gliomas: Potential Role of Microenvironment in Tumour Growth","volume":"8","author":"Loveson","year":"2018","journal-title":"Brain Sciences."},{"key":"10.1016\/j.brainres.2021.147348_b0110","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2019.108608","article-title":"Downregulation of RGMA by HIF-1A\/miR-210-3p axis promotes cell proliferation in oral squamous cell carcinoma","volume":"112","author":"Lu","year":"2019","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.brainres.2021.147348_b0115","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1038\/ncb1157","article-title":"RGM and its receptor neogenin regulate neuronal survival","volume":"6","author":"Matsunaga","year":"2004","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.brainres.2021.147348_b0120","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1016\/j.tibs.2019.10.005","article-title":"Netrin Synergizes Signaling and Adhesion through DCC","volume":"45","author":"Meijers","year":"2020","journal-title":"Trends Biochem. Sci."},{"issue":"635\u2013652","key":"10.1016\/j.brainres.2021.147348_b0125","article-title":"Transcriptional Dependencies in Diffuse Intrinsic Pontine Glioma","volume":"31","author":"Nagaraja","year":"2017","journal-title":"Cancer Cell"},{"issue":"965\u2013980","key":"10.1016\/j.brainres.2021.147348_b0130","article-title":"Histone Variant and Cell Context Determine H3K27M Reprogramming of the Enhancer Landscape and Oncogenic State","volume":"76","author":"Nagaraja","year":"2019","journal-title":"Mol. Cell"},{"key":"10.1016\/j.brainres.2021.147348_b0135","doi-asserted-by":"crossref","first-page":"2907","DOI":"10.1016\/j.yexcr.2008.07.013","article-title":"Shedding of epidermal growth factor receptor is a regulated process that occurs with overexpression in malignant cells","volume":"314","author":"Perez-Torres","year":"2008","journal-title":"Exp. Cell Res."},{"key":"10.1016\/j.brainres.2021.147348_b0140","doi-asserted-by":"crossref","first-page":"396","DOI":"10.3171\/2015.12.PEDS15448","article-title":"Using urinary bFGF and TIMP3 levels to predict the presence of juvenile pilocytic astrocytoma and establish a distinct biomarker signature","volume":"18","author":"Pricola Fehnel","year":"2016","journal-title":"J. Neurosurg. Pediatr."},{"key":"10.1016\/j.brainres.2021.147348_b0145","doi-asserted-by":"crossref","first-page":"756","DOI":"10.1038\/ncb1156","article-title":"Neogenin mediates the action of repulsive guidance molecule","volume":"6","author":"Rajagopalan","year":"2004","journal-title":"Nat. Cell Biol."},{"issue":"Pt 2","key":"10.1016\/j.brainres.2021.147348_b0150","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1042\/bj3000281","article-title":"Soluble receptors for cytokines and growth factors: generation and biological function","volume":"300","author":"Rose-John","year":"1994","journal-title":"Biochem. J."},{"key":"10.1016\/j.brainres.2021.147348_b0155","doi-asserted-by":"crossref","first-page":"14949","DOI":"10.1007\/s13277-016-5314-5","article-title":"Targeting Netrin-1 in glioblastoma stem-like cells inhibits growth, invasion, and angiogenesis","volume":"37","author":"Sanvoranart","year":"2016","journal-title":"Tumour Biol."},{"key":"10.1016\/j.brainres.2021.147348_b0160","doi-asserted-by":"crossref","first-page":"2210","DOI":"10.1074\/jbc.M112.397398","article-title":"Netrin-1 promotes glioblastoma cell invasiveness and angiogenesis by multiple pathways including activation of RhoA, cathepsin B, and cAMP-response element-binding protein","volume":"288","author":"Shimizu","year":"2013","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.brainres.2021.147348_b0165","doi-asserted-by":"crossref","first-page":"E1148","DOI":"10.1227\/01.NEU.0000255464.37634.3C","article-title":"A recurrent craniopharyngioma illustrates the potential usefulness of urinary matrix metalloproteinases as noninvasive biomarkers: case report","volume":"60","author":"Smith","year":"2007","journal-title":"Neurosurgery."},{"key":"10.1016\/j.brainres.2021.147348_b0170","doi-asserted-by":"crossref","first-page":"2378","DOI":"10.1158\/1078-0432.CCR-07-1253","article-title":"Urinary biomarkers predict brain tumor presence and response to therapy","volume":"14","author":"Smith","year":"2008","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.brainres.2021.147348_b0175","doi-asserted-by":"crossref","first-page":"9767","DOI":"10.18632\/oncotarget.14213","article-title":"The Netrin-4\/ Neogenin-1 axis promotes neuroblastoma cell survival and migration","volume":"8","author":"Villanueva","year":"2017","journal-title":"Oncotarget."},{"key":"10.1016\/j.brainres.2021.147348_b0180","doi-asserted-by":"crossref","first-page":"874","DOI":"10.1016\/j.biocel.2006.10.023","article-title":"Neogenin: one receptor, many functions","volume":"39","author":"Wilson","year":"2007","journal-title":"Int. J. Biochem. Cell Biol."},{"key":"10.1016\/j.brainres.2021.147348_b0185","article-title":"Netrin-1 promotes gastric cancer cell proliferation and invasion via the receptor neogenin through PI3K\/AKT signaling pathway","author":"Yin","year":"2017","journal-title":"Oncotarget."},{"key":"10.1016\/j.brainres.2021.147348_b0190","doi-asserted-by":"crossref","first-page":"3197","DOI":"10.7150\/jca.30230","article-title":"Netrin-1 promotes cell neural invasion in gastric cancer via its receptor neogenin","volume":"10","author":"Yin","year":"2019","journal-title":"J Cancer."},{"key":"10.1016\/j.brainres.2021.147348_b0195","first-page":"2459","article-title":"Netrin-1-induced activation of Notch signaling mediates glioblastoma cell invasion","volume":"126","author":"Ylivinkka","year":"2013","journal-title":"J. Cell Sci."},{"key":"10.1016\/j.brainres.2021.147348_b0200","doi-asserted-by":"crossref","DOI":"10.1186\/s13046-016-0482-0","article-title":"Motility of glioblastoma cells is driven by netrin-1 induced gain of stemness","volume":"36","author":"Ylivinkka","year":"2017","journal-title":"J. Exp. Clin. Cancer Res."}],"container-title":["Brain Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006899321000731?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006899321000731?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,13]],"date-time":"2025-09-13T18:16:34Z","timestamp":1757787394000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006899321000731"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,7]]},"references-count":40,"alternative-id":["S0006899321000731"],"URL":"https:\/\/doi.org\/10.1016\/j.brainres.2021.147348","relation":{},"ISSN":["0006-8993"],"issn-type":[{"type":"print","value":"0006-8993"}],"subject":[],"published":{"date-parts":[[2021,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Neogenin is highly expressed in diffuse intrinsic pontine glioma and influences tumor invasion","name":"articletitle","label":"Article Title"},{"value":"Brain Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.brainres.2021.147348","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"147348"}}