{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T16:33:00Z","timestamp":1787502780892,"version":"build-2736575974"},"reference-count":62,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100012467","name":"Distinguished Professor of Liaoning Province","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100012467","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Brain Research"],"published-print":{"date-parts":[[2021,12]]},"DOI":"10.1016\/j.brainres.2021.147684","type":"journal-article","created":{"date-parts":[[2021,10,11]],"date-time":"2021-10-11T08:02:30Z","timestamp":1633939350000},"page":"147684","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":11,"special_numbering":"C","title":["The ROCK inhibitor Y-27632 ameliorates blood-spinal cord barrier disruption by reducing tight junction protein degradation via the MYPT1-MLC2 pathway after spinal cord injury in rats"],"prefix":"10.1016","volume":"1773","author":[{"given":"Sheng","family":"Chang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Cao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.brainres.2021.147684_b0005","doi-asserted-by":"crossref","first-page":"1152","DOI":"10.1016\/j.jconrel.2020.11.021","article-title":"Neurodegenerative diseases and effective drug delivery: A review of challenges and novel therapeutics","volume":"330","author":"Akhtar","year":"2021","journal-title":"J. Control. Release"},{"key":"10.1016\/j.brainres.2021.147684_b0010","doi-asserted-by":"crossref","first-page":"27","DOI":"10.3389\/fneur.2019.00027","article-title":"Biomarkers in spinal cord injury: prognostic insights and future potentials","volume":"10","author":"Albayar","year":"2019","journal-title":"Front. Neurol."},{"issue":"4","key":"10.1016\/j.brainres.2021.147684_b0015","doi-asserted-by":"crossref","first-page":"865","DOI":"10.1111\/jnc.15470","article-title":"Distinct Dose-dependent effects of methamphetamine on real-time dopamine transmission in the rat nucleus accumbens and behaviors","volume":"158","author":"Bhimani","year":"2021","journal-title":"J. Neurochem."},{"key":"10.1016\/j.brainres.2021.147684_b0020","doi-asserted-by":"crossref","first-page":"105226","DOI":"10.1016\/j.phrs.2020.105226","article-title":"Repairing blood-CNS barriers: Future therapeutic approaches for neuropsychiatric disorders","volume":"162","author":"Bicker","year":"2020","journal-title":"Pharmacol. Res."},{"issue":"19","key":"10.1016\/j.brainres.2021.147684_b0025","doi-asserted-by":"crossref","first-page":"1759","DOI":"10.4155\/fmc-2020-0178","article-title":"Recent progress in therapeutic drug delivery systems for treatment of traumatic CNS injuries","volume":"12","author":"Khadka","year":"2020","journal-title":"FutureMed. Chem"},{"key":"10.1016\/j.brainres.2021.147684_b0030","article-title":"Identification of deep brain stimulation targets for neuropathic pain after spinal cord injury using localized increases in white matter fiber cross-section","author":"Black","year":"2021","journal-title":"Neuromodulation"},{"issue":"12","key":"10.1016\/j.brainres.2021.147684_b0035","doi-asserted-by":"crossref","first-page":"3132","DOI":"10.1002\/jcp.22669","article-title":"The suppression of myosin light chain (MLC) phosphorylation during the response to lipopolysaccharide (LPS): beneficial or detrimental to endothelial barrier?","volume":"226","author":"Bogatcheva","year":"2011","journal-title":"J. Cell. Physiol."},{"key":"10.1016\/j.brainres.2021.147684_b0040","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1016\/j.msec.2018.11.048","article-title":"Improvement of calcium phosphate scaffold osteogenesis in vitro via combination of glutamate-modified BMP-2 peptides","volume":"96","author":"Cao","year":"2019","journal-title":"Mater. Sci. Eng. C Mater. Biol. Appl."},{"issue":"2","key":"10.1016\/j.brainres.2021.147684_b0045","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1016\/j.expneurol.2005.08.011","article-title":"Dose-dependent beneficial and detrimental effects of ROCK inhibitor Y27632 on axonal sprouting and functional recovery after rat spinal cord injury","volume":"196","author":"Chan","year":"2005","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.brainres.2021.147684_b0050","doi-asserted-by":"crossref","first-page":"672","DOI":"10.1097\/WNR.0000000000001632","article-title":"Sulfasalazine maintains blood-brain barrier integrity and relieves lipopolysaccharide-induced inflammation in hCMEC\/D3 cells","volume":"32","author":"Chang","year":"2021","journal-title":"NeuroReport"},{"key":"10.1016\/j.brainres.2021.147684_b0055","article-title":"Immortalization and characterization of rat lingual keratinocytes in a high-calcium and feeder-free culture system using ROCK inhibitor Y-27632","volume":"22","author":"Chen","year":"2021","journal-title":"Int. J. Mol. Sci."},{"issue":"8","key":"10.1016\/j.brainres.2021.147684_b0060","doi-asserted-by":"crossref","first-page":"4395","DOI":"10.1002\/mp.14947","article-title":"Technical Note: Quantification of blood-spinal cord barrier permeability after application of magnetic resonance-guided focused ultrasound in spinal cord injury","volume":"48","author":"Cross","year":"2021","journal-title":"Med. Phys."},{"issue":"13","key":"10.1016\/j.brainres.2021.147684_b0065","doi-asserted-by":"crossref","first-page":"1082","DOI":"10.1097\/WNR.0000000000001694","article-title":"Comparative study of the reorganization in bilateral motor and sensory cortices after spinal cord hemisection in mice","volume":"32","author":"Deng","year":"2021","journal-title":"NeuroReport"},{"key":"10.1016\/j.brainres.2021.147684_b0070","doi-asserted-by":"crossref","DOI":"10.1016\/j.gene.2021.145528","article-title":"Mash-1 modified neural stem cells transplantation promotes neural stem cells differentiation into neurons to further improve locomotor functional recovery in spinal cord injury rats","volume":"781","author":"Deng","year":"2021","journal-title":"Gene"},{"key":"10.1016\/j.brainres.2021.147684_b0075","doi-asserted-by":"crossref","DOI":"10.3390\/mps4030048","article-title":"Experimental protocol to assess neuromuscular plasticity induced by an exoskeleton training session","volume":"4","author":"Di Marco","year":"2021","journal-title":"Methods Protoc."},{"issue":"9","key":"10.1016\/j.brainres.2021.147684_b0080","doi-asserted-by":"crossref","first-page":"4652","DOI":"10.1007\/s12035-021-02443-5","article-title":"Neutrophil, extracellular matrix components, and their interlinked action in promoting secondary pathogenesis after spinal cord injury","volume":"58","author":"Dolma","year":"2021","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.brainres.2021.147684_b0085","doi-asserted-by":"crossref","first-page":"881","DOI":"10.21037\/atm-21-2063","article-title":"A novel, minimally invasive technique to establish the animal model of spinal cord injury","volume":"9","author":"Duan","year":"2021","journal-title":"Ann. Transl. Med."},{"issue":"8","key":"10.1016\/j.brainres.2021.147684_b0090","doi-asserted-by":"crossref","first-page":"1488","DOI":"10.1007\/s00125-019-4885-2","article-title":"Modulation of the p75 neurotrophin receptor using LM11A-31 prevents diabetes-induced retinal vascular permeability in mice via inhibition of inflammation and the RhoA kinase pathway","volume":"62","author":"Elshaer","year":"2019","journal-title":"Diabetologia"},{"key":"10.1016\/j.brainres.2021.147684_b0095","doi-asserted-by":"crossref","DOI":"10.3390\/cells8090964","article-title":"ROCK inhibition drives resolution of acute inflammation by enhancing neutrophil apoptosis","volume":"8","author":"Galvao","year":"2019","journal-title":"Cells"},{"key":"10.1016\/j.brainres.2021.147684_b0100","doi-asserted-by":"crossref","first-page":"844","DOI":"10.21037\/atm-21-1526","article-title":"Electroacupuncture promotes the recovery of rats with spinal cord injury by suppressing the Notch signaling pathway via the H19\/EZH2 axis","volume":"9","author":"Geng","year":"2021","journal-title":"Ann. Transl. Med."},{"key":"10.1016\/j.brainres.2021.147684_b0105","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/B978-0-444-64034-5.00007-9","article-title":"Neurovascular anatomy: Spine","volume":"176","author":"Gregg","year":"2021","journal-title":"Handb. Clin. Neurol."},{"key":"10.1016\/j.brainres.2021.147684_b0110","doi-asserted-by":"crossref","DOI":"10.1016\/j.brainres.2021.147576","article-title":"MiR-212-3p improves rat functional recovery and inhibits neurocyte apoptosis in spinal cord injury models via PTEN downregulation-mediated activation of AKT\/mTOR pathway","volume":"1768","author":"Guan","year":"2021","journal-title":"Brain Res."},{"issue":"11","key":"10.1016\/j.brainres.2021.147684_b0115","doi-asserted-by":"crossref","first-page":"2979","DOI":"10.1007\/s11064-021-03401-2","article-title":"Protective effects of estrogen via nanoparticle delivery to attenuate myelin loss and neuronal death after spinal cord injury","volume":"46","author":"Haque","year":"2021","journal-title":"Neurochem. Res."},{"key":"10.1016\/j.brainres.2021.147684_b0120","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1007\/s00441-021-03430-x","article-title":"Thermosensitive quaternized chitosan hydrogel scaffolds promote neural differentiation in bone marrow mesenchymal stem cells and functional recovery in a rat spinal cord injury model","volume":"385","author":"Huang","year":"2021","journal-title":"Cell Tissue Res."},{"key":"10.1016\/j.brainres.2021.147684_b0125","doi-asserted-by":"crossref","first-page":"101","DOI":"10.3389\/fbioe.2020.00101","article-title":"The integrated transcriptome bioinformatics analysis identifies key genes and cellular components for spinal cord injury-related neuropathic pain","volume":"8","author":"Huang","year":"2020","journal-title":"Front. Bioeng. Biotechnol."},{"key":"10.1016\/j.brainres.2021.147684_b0130","doi-asserted-by":"crossref","DOI":"10.1007\/s12013-021-00992-z","article-title":"Inhibition of miR-145-5p reduces spinal cord injury-induced inflammatory and oxidative stress responses via affecting Nurr1-TNF-alpha signaling axis","author":"Jiang","year":"2021","journal-title":"Cell Biochem. Biophys."},{"key":"10.1016\/j.brainres.2021.147684_b0135","doi-asserted-by":"crossref","first-page":"1203","DOI":"10.1089\/neu.2020.7413","article-title":"Blood-spinal cord barrier in spinal cord injury: A review","volume":"38","author":"Jin","year":"2021","journal-title":"J. Neurotrauma"},{"key":"10.1016\/j.brainres.2021.147684_b0140","doi-asserted-by":"crossref","first-page":"2671","DOI":"10.1007\/s12035-020-01914-5","article-title":"CORM-2-solid lipid nanoparticles maintain integrity of blood-spinal cord barrier after spinal cord injury in rats","volume":"57","author":"Joshi","year":"2020","journal-title":"Mol. Neurobiol."},{"issue":"1","key":"10.1016\/j.brainres.2021.147684_b0145","doi-asserted-by":"crossref","first-page":"L35","DOI":"10.1152\/ajplung.00012.2018","article-title":"Connexin 40 regulates lung endothelial permeability in acute lung injury via the ROCK1-MYPT1- MLC20 pathway","volume":"316","author":"Yin","year":"2019","journal-title":"Am. J. Physiol. Lung Cell Mol. Physiol."},{"key":"10.1016\/j.brainres.2021.147684_b0150","article-title":"A validated quantitative method for the assessment of neuroprotective barrier impairment in neurodegenerative disease models","author":"Kumar","year":"2020","journal-title":"J. Neurochem."},{"key":"10.1016\/j.brainres.2021.147684_b0155","doi-asserted-by":"crossref","first-page":"348","DOI":"10.13004\/kjnt.2020.16.e38","article-title":"Anterior spinal artery syndrome occurring after one level segmental artery ligation during spinal surgery","volume":"16","author":"Kwon","year":"2020","journal-title":"Korean J. Neurotrauma"},{"key":"10.1016\/j.brainres.2021.147684_b0160","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1089\/neur.2020.0041","article-title":"Enteric nervous system remodeling in a rat model of spinal cord injury: A pilot study","volume":"1","author":"Lefevre","year":"2020","journal-title":"Neurotrauma Rep."},{"key":"10.1016\/j.brainres.2021.147684_b0165","doi-asserted-by":"crossref","first-page":"7207692","DOI":"10.1155\/2021\/7207692","article-title":"Sirtuins: potential therapeutic targets for defense against oxidative stress in spinal cord injury","volume":"2021","author":"Lin","year":"2021","journal-title":"Oxid. Med. Cell. Longev."},{"key":"10.1016\/j.brainres.2021.147684_b0170","doi-asserted-by":"crossref","DOI":"10.3389\/fnagi.2021.701702","article-title":"Ultrarapid inflammation of the olfactory bulb after spinal cord injury: protective effects of the granulocyte colony-stimulating factor on early neurodegeneration in the brain","volume":"13","author":"Lin","year":"2021","journal-title":"Front. Aging Neurosci."},{"key":"10.1016\/j.brainres.2021.147684_b0175","doi-asserted-by":"crossref","DOI":"10.1016\/j.brainres.2021.147296","article-title":"Intravenous infusion of mesenchymal stem cells delays disease progression in the SOD1G93A transgenic amyotrophic lateral sclerosis rat model","volume":"1757","author":"Magota","year":"2021","journal-title":"Brain Res."},{"key":"10.1016\/j.brainres.2021.147684_b0180","article-title":"Direct cost of illness for spinal cord injury: A systematic review","author":"Malekzadeh","year":"2021","journal-title":"Global Spine J."},{"key":"10.1016\/j.brainres.2021.147684_b0185","doi-asserted-by":"crossref","first-page":"378","DOI":"10.4103\/1673-5374.317982","article-title":"Rapid GFAP and Iba1 expression changes in the female rat brain following spinal cord injury","volume":"17","author":"Mandwie","year":"2022","journal-title":"Neural Regen. Res."},{"key":"10.1016\/j.brainres.2021.147684_b0190","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1007\/s10911-021-09479-2","article-title":"Characterizing the tumor immune microenvironment with tyramide-based multiplex immunofluorescence","volume":"25","author":"Mori","year":"2020","journal-title":"J. Mammary Gland Biol. Neoplasia"},{"issue":"10","key":"10.1016\/j.brainres.2021.147684_b0195","doi-asserted-by":"crossref","first-page":"3107","DOI":"10.1007\/s00586-021-06931-z","article-title":"Pathological changes within two weeks following spinal cord injury in a canine model","volume":"30","author":"Nakamoto","year":"2021","journal-title":"Eur. Spine J."},{"key":"10.1016\/j.brainres.2021.147684_b0200","doi-asserted-by":"crossref","DOI":"10.1016\/j.nbd.2020.105077","article-title":"Gallic acid attenuates blood-spinal cord barrier disruption by inhibiting Jmjd3 expression and activation after spinal cord injury","volume":"145","author":"Park","year":"2020","journal-title":"Neurobiol. Dis."},{"issue":"6","key":"10.1016\/j.brainres.2021.147684_b0205","doi-asserted-by":"crossref","first-page":"325","DOI":"10.21037\/atm.2020.02.106","article-title":"Tissue cross-reactivity studies of CPGJ701 in humans, cynomolgus monkeys and Sprague-Dawley rats and correlation analysis with in vivo toxicity","volume":"8","author":"Qu","year":"2020","journal-title":"Ann. Transl. Med."},{"key":"10.1016\/j.brainres.2021.147684_b0210","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1111\/nyas.13436","article-title":"Blood-spinal cord barrier breakdown and pericyte deficiency in peripheral neuropathy","volume":"1405","author":"Sauer","year":"2017","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"10.1016\/j.brainres.2021.147684_b0215","doi-asserted-by":"crossref","DOI":"10.3390\/ijms21239078","article-title":"AKAP12 Supports Blood-Brain Barrier Integrity against Ischemic Stroke","volume":"21","author":"Seo","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.brainres.2021.147684_b0220","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1016\/j.neuroscience.2018.05.037","article-title":"Effects of low doses of ketamine on pyramidal neurons in rat prefrontal cortex","volume":"384","author":"Shen","year":"2018","journal-title":"Neuroscience"},{"key":"10.1016\/j.brainres.2021.147684_b0225","doi-asserted-by":"crossref","DOI":"10.1016\/j.expneurol.2021.113720","article-title":"FDA-approved 5-HT1F receptor agonist lasmiditan induces mitochondrial biogenesis and enhances locomotor and blood-spinal cord barrier recovery after spinal cord injury","volume":"341","author":"Simmons","year":"2021","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.brainres.2021.147684_b0230","doi-asserted-by":"crossref","first-page":"1255","DOI":"10.4103\/1673-5374.251334","article-title":"Use of ebselen as a neuroprotective agent in rat spinal cord subjected to traumatic injury","volume":"14","author":"Slusarczyk","year":"2019","journal-title":"Neural Regen Res"},{"key":"10.1016\/j.brainres.2021.147684_b0235","doi-asserted-by":"crossref","first-page":"2079","DOI":"10.1021\/acschemneuro.0c00720","article-title":"Mass spectrometric enzyme histochemistry for choline acetyltransferase reveals de novo acetylcholine synthesis in rodent brain and spinal cord","volume":"12","author":"Takeo","year":"2021","journal-title":"ACS Chem. Neurosci."},{"key":"10.1016\/j.brainres.2021.147684_b0240","doi-asserted-by":"crossref","DOI":"10.1016\/j.neulet.2021.135971","article-title":"Sigma 1 receptor agonist cutamesine promotes plasticity of serotonergic boutons in lumbar enlargement in spinal cord injured rats","volume":"759","author":"Tanji","year":"2021","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.brainres.2021.147684_b0245","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1080\/01616412.2020.1773610","article-title":"Pycnogenol achieves neuroprotective effects in rats with spinal cord injury by stabilizing the mitochondrial membrane potential","volume":"42","author":"Tao","year":"2020","journal-title":"Neurol. Res."},{"issue":"10","key":"10.1016\/j.brainres.2021.147684_b0250","doi-asserted-by":"crossref","first-page":"3028","DOI":"10.1007\/s00586-021-06905-1","article-title":"A review of spinal cord perfusion pressure guided interventions in traumatic spinal cord injury","volume":"30","author":"Thygesen","year":"2021","journal-title":"Eur. Spine J."},{"key":"10.1016\/j.brainres.2021.147684_b0255","doi-asserted-by":"crossref","first-page":"2006","DOI":"10.1021\/acs.molpharmaceut.0c00178","article-title":"Comparison of absolute protein abundances of transporters and receptors among blood-brain barriers at different cerebral regions and the blood-spinal cord barrier in humans and rats","volume":"17","author":"Uchida","year":"2020","journal-title":"Mol. Pharm."},{"key":"10.1016\/j.brainres.2021.147684_b0260","doi-asserted-by":"crossref","DOI":"10.1016\/j.jchemneu.2021.101924","article-title":"Therapeutics effects of [Pyr1] apelin-13 on rat contusion model of spinal cord injury: An experimental study","volume":"113","author":"Vafaei-Nezhad","year":"2021","journal-title":"J. Chem. Neuroanat."},{"key":"10.1016\/j.brainres.2021.147684_b0265","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1369\/00221554211022703","article-title":"Autocrine hyaluronan influences sprouting and lumen formation during HUVEC Tubulogenesis in vitro","volume":"69","author":"Vernon","year":"2021","journal-title":"J. Histochem. Cytochem."},{"key":"10.1016\/j.brainres.2021.147684_b0270","doi-asserted-by":"crossref","first-page":"1031","DOI":"10.1021\/acschemneuro.1c00054","article-title":"Bradykinin activates the bradykinin B2 receptor to ameliorate neuronal injury in a rat model of spinal cord ischemia-reperfusion injury","volume":"12","author":"Yang","year":"2021","journal-title":"ACS Chem. Neurosci."},{"key":"10.1016\/j.brainres.2021.147684_b0275","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1515\/tnsci-2021-0012","article-title":"Euxanthone inhibits traumatic spinal cord injury via anti-oxidative stress and suppression of p38 and PI3K\/Akt signaling pathway in a rat model","volume":"12","author":"Yao","year":"2021","journal-title":"Transl. Neurosci."},{"key":"10.1016\/j.brainres.2021.147684_b0280","article-title":"P53 inhibitor pifithrin-alpha inhibits ropivacaine-induced neuronal apoptosis via the mitochondrial apoptosis pathway","volume":"e22822","author":"Zeng","year":"2021","journal-title":"J. Biochem. Mol. Toxicol."},{"key":"10.1016\/j.brainres.2021.147684_b0285","doi-asserted-by":"crossref","first-page":"1850","DOI":"10.1002\/jnr.24839","article-title":"Effects of the combination therapy of electric field stimulation and polyethylene glycol in the ex vivo spinal cord of female rats after compression","volume":"99","author":"Zhang","year":"2021","journal-title":"J. Neurosci. Res."},{"key":"10.1016\/j.brainres.2021.147684_b0290","doi-asserted-by":"crossref","first-page":"6768","DOI":"10.21037\/apm-21-1218","article-title":"Dexmedetomidine attenuates cerebral ischemia-reperfusion injury in rats by inhibiting the JNK pathway","volume":"10","author":"Zhao","year":"2021","journal-title":"Ann. Palliat. Med."},{"key":"10.1016\/j.brainres.2021.147684_b0295","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1007\/s11064-020-03211-y","article-title":"MicroRNA-24-3p inhibits microglia inflammation by regulating MK2 following spinal cord injury","volume":"46","author":"Zhao","year":"2021","journal-title":"Neurochem. Res."},{"key":"10.1016\/j.brainres.2021.147684_b0300","doi-asserted-by":"crossref","first-page":"9280","DOI":"10.7150\/thno.46566","article-title":"TFE3, a potential therapeutic target for Spinal Cord Injury via augmenting autophagy flux and alleviating ER stress","volume":"10","author":"Zhou","year":"2020","journal-title":"Theranostics"},{"key":"10.1016\/j.brainres.2021.147684_b0305","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1038\/s41419-021-03546-6","article-title":"AAV2-mediated and hypoxia response element-directed expression of bFGF in neural stem cells showed therapeutic effects on spinal cord injury in rats","volume":"12","author":"Zhu","year":"2021","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.brainres.2021.147684_b0310","first-page":"430","article-title":"Inhibition of Rho kinase protects against colitis in mice by attenuating intestinal epithelial barrier dysfunction via MLC and the NF-kappaB pathway","volume":"41","author":"Zou","year":"2018","journal-title":"Int. J. Mol. Med."}],"container-title":["Brain Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006899321005412?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006899321005412?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,2]],"date-time":"2025-11-02T17:05:31Z","timestamp":1762103131000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006899321005412"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,12]]},"references-count":62,"alternative-id":["S0006899321005412"],"URL":"https:\/\/doi.org\/10.1016\/j.brainres.2021.147684","relation":{},"ISSN":["0006-8993"],"issn-type":[{"value":"0006-8993","type":"print"}],"subject":[],"published":{"date-parts":[[2021,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The ROCK inhibitor Y-27632 ameliorates blood-spinal cord barrier disruption by reducing tight junction protein degradation via the MYPT1-MLC2 pathway after spinal cord injury in rats","name":"articletitle","label":"Article Title"},{"value":"Brain Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.brainres.2021.147684","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"147684"}}