{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,17]],"date-time":"2026-01-17T20:22:16Z","timestamp":1768681336485,"version":"3.49.0"},"reference-count":35,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,2,1]],"date-time":"2022-02-01T00:00:00Z","timestamp":1643673600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,2,1]],"date-time":"2022-02-01T00:00:00Z","timestamp":1643673600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,2,1]],"date-time":"2022-02-01T00:00:00Z","timestamp":1643673600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2022,2,1]],"date-time":"2022-02-01T00:00:00Z","timestamp":1643673600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,2,1]],"date-time":"2022-02-01T00:00:00Z","timestamp":1643673600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2022,2,1]],"date-time":"2022-02-01T00:00:00Z","timestamp":1643673600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,2,1]],"date-time":"2022-02-01T00:00:00Z","timestamp":1643673600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["8190 2570"],"award-info":[{"award-number":["8190 2570"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Brain Research"],"published-print":{"date-parts":[[2022,2]]},"DOI":"10.1016\/j.brainres.2021.147754","type":"journal-article","created":{"date-parts":[[2021,12,17]],"date-time":"2021-12-17T10:56:36Z","timestamp":1639738596000},"page":"147754","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"special_numbering":"C","title":["The role of lumbosacral innervating noradrenergic neurons in micturition control"],"prefix":"10.1016","volume":"1777","author":[{"given":"Long","family":"Ma","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jing-Yuan","family":"Tang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jin-Yong","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ping","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chen","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xin","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jing-Quan","family":"Ding","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hong-Qian","family":"Jia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiao-Jian","family":"Gu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.brainres.2021.147754_b0005","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1113\/expphysiol.1925.sp000345","article-title":"THE EFFECT OF LESIONS OF THE HIND- AND MID-BRAIN ON MICTURITION IN THE CAT","volume":"15","author":"Barrington","year":"1925","journal-title":"Quarterly Journal of Experimental Physiology."},{"key":"10.1016\/j.brainres.2021.147754_b0010","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1111\/j.1464-410X.1992.tb15679.x","article-title":"Pontine pathology and voiding dysfunction","volume":"70","author":"Betts","year":"1992","journal-title":"Br J Urol."},{"key":"10.1016\/j.brainres.2021.147754_b0015","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/S0166-4328(97)00184-8","article-title":"The central nervous system control of micturition in cats and humans","volume":"92","author":"Blok","year":"1998","journal-title":"Behav Brain Res."},{"key":"10.1016\/j.brainres.2021.147754_b0020","doi-asserted-by":"crossref","first-page":"1985","DOI":"10.1002\/cne.23024","article-title":"Spinal projections of the A5, A6 (locus coeruleus), and A7 noradrenergic cell groups in rats","volume":"520","author":"Bruinstroop","year":"2012","journal-title":"J Comp Neurol."},{"key":"10.1016\/j.brainres.2021.147754_b0025","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/S0166-4328(97)00185-X","article-title":"Developmental and injury induced plasticity in the micturition reflex pathway","volume":"92","author":"de Groat","year":"1998","journal-title":"Behav Brain Res."},{"key":"10.1016\/j.brainres.2021.147754_b0030","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1002\/j.2040-4603.2015.tb00596.x","article-title":"Neural control of the lower urinary tract","volume":"5","author":"de Groat","year":"2015","journal-title":"Compr Physiol."},{"key":"10.1016\/j.brainres.2021.147754_b0035","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1038\/nrn2401","article-title":"The neural control of micturition","volume":"9","author":"Fowler","year":"2008","journal-title":"Nat Rev Neurosci."},{"key":"10.1016\/j.brainres.2021.147754_b0040","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1007\/s11884-011-0083-x","article-title":"New Insights into the Pathophysiology of Detrusor-Sphincter Dyssynergia","volume":"6","author":"Fraser","year":"2011","journal-title":"Current Bladder Dysfunction Reports."},{"key":"10.1016\/j.brainres.2021.147754_b0045","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/0306-4522(89)90364-3","article-title":"Immunohistochemical analysis of the neurotoxic effects of DSP-4 identifies two populations of noradrenergic axon terminals","volume":"30","author":"Fritschy","year":"1989","journal-title":"Neuroscience."},{"key":"10.1016\/j.brainres.2021.147754_b0050","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.29808","article-title":"Functional dichotomy in spinal- vs prefrontal-projecting locus coeruleus modules splits descending noradrenergic analgesia from ascending aversion and anxiety in rats","volume":"6","author":"Hirschberg","year":"2017","journal-title":"Elife."},{"key":"10.1016\/j.brainres.2021.147754_b0055","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/j.cell.2016.08.073","article-title":"Central Control Circuit for Context-Dependent Micturition","volume":"167","author":"Hou","year":"2016","journal-title":"Cell."},{"key":"10.1016\/j.brainres.2021.147754_b0060","doi-asserted-by":"crossref","first-page":"13656","DOI":"10.1523\/JNEUROSCI.2566-14.2014","article-title":"Phasic activation of individual neurons in the locus ceruleus\/subceruleus complex of monkeys reflects rewarded decisions to go but not stop","volume":"34","author":"Kalwani","year":"2014","journal-title":"J Neurosci."},{"key":"10.1016\/j.brainres.2021.147754_b0065","doi-asserted-by":"crossref","first-page":"1229","DOI":"10.1038\/s41593-018-0204-3","article-title":"Voluntary urination control by brainstem neurons that relax the urethral sphincter","volume":"21","author":"Keller","year":"2018","journal-title":"Nat Neurosci."},{"key":"10.1016\/j.brainres.2021.147754_b0070","doi-asserted-by":"crossref","first-page":"953","DOI":"10.1136\/jnnp.65.6.953","article-title":"Urinary retention associated with a unilateral lesion in the dorsolateral tegmentum of the rostral pons","volume":"65","author":"Komiyama","year":"1998","journal-title":"J Neurol Neurosurg Psychiatry."},{"key":"10.1016\/j.brainres.2021.147754_b0075","first-page":"R1157","article-title":"Changes in bladder and external urethral sphincter function after spinal cord injury in the rat","volume":"264","author":"Kruse","year":"1993","journal-title":"Am J Physiol."},{"key":"10.1016\/j.brainres.2021.147754_b0080","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1038\/nature13974","article-title":"Modulation of the proteoglycan receptor PTP\u03c3 promotes recovery after spinal cord injury","volume":"518","author":"Lang","year":"2015","journal-title":"Nature."},{"key":"10.1016\/j.brainres.2021.147754_b0085","doi-asserted-by":"crossref","first-page":"10591","DOI":"10.1523\/JNEUROSCI.1116-12.2013","article-title":"Nerve regeneration restores supraspinal control of bladder function after complete spinal cord injury","volume":"33","author":"Lee","year":"2013","journal-title":"J Neurosci."},{"key":"10.1016\/j.brainres.2021.147754_b0090","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/j.neuroscience.2016.05.057","article-title":"Noradrenergic Locus Coeruleus pathways in pain modulation","volume":"338","author":"Llorca-Torralba","year":"2016","journal-title":"Neuroscience."},{"key":"10.1016\/j.brainres.2021.147754_b0095","doi-asserted-by":"crossref","first-page":"2093","DOI":"10.4103\/1673-5374.308667","article-title":"Fluoxetine, a selective serotonin reuptake inhibitor used clinically, improves bladder function in a mouse model of moderate spinal cord injury","volume":"16","author":"Ma","year":"2021","journal-title":"Neural Regen Res."},{"key":"10.1016\/j.brainres.2021.147754_b0100","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.29917","article-title":"Brainstem network dynamics underlying the encoding of bladder information","volume":"6","author":"Manohar","year":"2017","journal-title":"Elife."},{"key":"10.1016\/j.brainres.2021.147754_b0105","doi-asserted-by":"crossref","first-page":"532","DOI":"10.1002\/cne.902480406","article-title":"The organization of the pudendal nerve in the male and female rat","volume":"248","author":"McKenna","year":"1986","journal-title":"J Comp Neurol."},{"key":"10.1016\/j.brainres.2021.147754_b0110","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1073\/pnas.72.2.659","article-title":"Ultrastructural localization of tyrosine hydroxylase in noradrenergic neurons of brain","volume":"72","author":"Pickel","year":"1975","journal-title":"Proc Natl Acad Sci U S A."},{"key":"10.1016\/j.brainres.2021.147754_b0115","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1523\/JNEUROSCI.21-02-00559.2001","article-title":"Coordination of the bladder detrusor and the external urethral sphincter in a rat model of spinal cord injury: effect of injury severity","volume":"21","author":"Pikov","year":"2001","journal-title":"J Neurosci."},{"key":"10.1016\/j.brainres.2021.147754_b0120","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/S0079-6123(08)63803-0","article-title":"The projections of locus coeruleus neurons to the spinal cord","volume":"88","author":"Proudfit","year":"1991","journal-title":"Prog Brain Res."},{"key":"10.1016\/j.brainres.2021.147754_b0125","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1002\/jemt.1070290308","article-title":"Locus coeruleus noradrenergic neurons as a micturition center","volume":"29","author":"Sasa","year":"1994","journal-title":"Microsc Res Tech."},{"key":"10.1016\/j.brainres.2021.147754_b0130","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/0304-3940(78)90092-7","article-title":"Localization of the micturition reflex center at dorsolateral pontine tegmentum of the rat","volume":"8","author":"Satoh","year":"1978","journal-title":"Neurosci Lett."},{"key":"10.1016\/j.brainres.2021.147754_b0135","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1038\/nature14600","article-title":"Viral-genetic tracing of the input-output organization of a central noradrenaline circuit","volume":"524","author":"Schwarz","year":"2015","journal-title":"Nature."},{"key":"10.1016\/j.brainres.2021.147754_b0140","doi-asserted-by":"crossref","first-page":"548","DOI":"10.1002\/nau.20552","article-title":"Voided stain on paper method for analysis of mouse urination","volume":"27","author":"Sugino","year":"2008","journal-title":"Neurourol Urodyn."},{"key":"10.1016\/j.brainres.2021.147754_b0145","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/0306-4522(94)90320-4","article-title":"Evidence for widespread afferents to Barrington's nucleus, a brainstem region rich in corticotropin-releasing hormone neurons","volume":"62","author":"Valentino","year":"1994","journal-title":"Neuroscience."},{"key":"10.1016\/j.brainres.2021.147754_b0150","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/0006-8993(96)00482-9","article-title":"Evidence for divergent projections to the brain noradrenergic system and the spinal parasympathetic system from Barrington's nucleus","volume":"732","author":"Valentino","year":"1996","journal-title":"Brain Res."},{"key":"10.1016\/j.brainres.2021.147754_b0155","doi-asserted-by":"crossref","first-page":"2287","DOI":"10.1002\/cne.24215","article-title":"Barrington's nucleus: Neuroanatomic landscape of the mouse \u201cpontine micturition center\u201d","volume":"525","author":"Verstegen","year":"2017","journal-title":"J Comp Neurol."},{"key":"10.1016\/j.brainres.2021.147754_b0160","doi-asserted-by":"crossref","first-page":"2775","DOI":"10.1016\/j.cub.2019.07.009","article-title":"Non-Crh Glutamatergic Neurons in Barrington's Nucleus Control Micturition via Glutamatergic Afferents from the Midbrain and Hypothalamus","volume":"29","author":"Verstegen","year":"2019","journal-title":"Curr Biol."},{"key":"10.1016\/j.brainres.2021.147754_b0165","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1002\/cne.903550411","article-title":"Transneuronal labeling of neurons in the adult rat brainstem and spinal cord after injection of pseudorabies virus into the urethra","volume":"355","author":"Vizzard","year":"1995","journal-title":"J Comp Neurol."},{"key":"10.1016\/j.brainres.2021.147754_b0170","doi-asserted-by":"crossref","first-page":"1541","DOI":"10.1038\/s41593-018-0256-4","article-title":"A corticopontine circuit for initiation of urination","volume":"21","author":"Yao","year":"2018","journal-title":"Nat Neurosci."},{"key":"10.1016\/j.brainres.2021.147754_b0175","doi-asserted-by":"crossref","first-page":"840","DOI":"10.1016\/S0022-5347(17)40113-3","article-title":"Mediation of micturition reflex by central norepinephrine from the locus coeruleus in the cat","volume":"143","author":"Yoshimura","year":"1990","journal-title":"J Urol."}],"container-title":["Brain Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006899321006132?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006899321006132?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,13]],"date-time":"2025-09-13T18:18:41Z","timestamp":1757787521000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006899321006132"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,2]]},"references-count":35,"alternative-id":["S0006899321006132"],"URL":"https:\/\/doi.org\/10.1016\/j.brainres.2021.147754","relation":{},"ISSN":["0006-8993"],"issn-type":[{"value":"0006-8993","type":"print"}],"subject":[],"published":{"date-parts":[[2022,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The role of lumbosacral innervating noradrenergic neurons in micturition control","name":"articletitle","label":"Article Title"},{"value":"Brain Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.brainres.2021.147754","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"147754"}}