{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T18:47:11Z","timestamp":1792090031881,"version":"4.4.0"},"reference-count":85,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100004482","name":"Kuwait University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004482","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Brain Research"],"published-print":{"date-parts":[[2023,1]]},"DOI":"10.1016\/j.brainres.2022.148134","type":"journal-article","created":{"date-parts":[[2022,10,31]],"date-time":"2022-10-31T18:30:12Z","timestamp":1667241012000},"page":"148134","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":15,"special_numbering":"C","title":["Early time course of oxidative stress in hippocampal synaptosomes and cognitive loss following impaired insulin signaling in rats: Development of sporadic Alzheimer\u2019s disease"],"prefix":"10.1016","volume":"1798","author":[{"given":"Mubeen A.","family":"Ansari","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muddanna S.","family":"Rao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aishah","family":"Al-Jarallah","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fawzi M.","family":"Babiker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"4","key":"10.1016\/j.brainres.2022.148134_b0005","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1016\/j.pbb.2005.06.007","article-title":"Neuroprotection by crocetin in a hemi-parkinsonian rat model","volume":"81","author":"Ahmad","year":"2005","journal-title":"Pharmacol. Biochem. Behav."},{"key":"10.1016\/j.brainres.2022.148134_b0010","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1111\/j.1463-1326.2008.00987.x","article-title":"Antioxidants attenuate hyperglycaemia-mediated brain endothelial cell dysfunction and blood-brain barrier hyperpermeability","volume":"11","author":"Allen","year":"2009","journal-title":"Diabetes Obes. Metab."},{"key":"10.1016\/j.brainres.2022.148134_b0015","article-title":"Biochanin-A has antidiabetic, antihyperlipidemic, antioxidant, and protective effects on diabetic nephropathy via suppression of TGF-\u03b21 and PAR-2 genes expression in kidney tissues of STZ-induced diabetic rats","author":"Amri","year":"2021","journal-title":"Biotechnol. Appl. Biochem."},{"issue":"11","key":"10.1016\/j.brainres.2022.148134_b0020","doi-asserted-by":"crossref","first-page":"1694","DOI":"10.1016\/j.freeradbiomed.2006.09.002","volume":"41","author":"Ansari","year":"2006","journal-title":"Free Radic Biol Med."},{"key":"10.1016\/j.brainres.2022.148134_b0025","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1016\/j.freeradbiomed.2008.04.038","article-title":"Oxidative stress and modification of synaptic proteins in hippocampus after traumatic brain injury","volume":"45","author":"Ansari","year":"2008","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.brainres.2022.148134_b0030","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1089\/neu.2007.0451","article-title":"A time course of contusion-induced oxidative stress and synaptic proteins in cortex in a rat model of TBI","volume":"25","author":"Ansari","year":"2008","journal-title":"J. Neurotrauma"},{"key":"10.1016\/j.brainres.2022.148134_b0035","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1016\/j.jnutbio.2008.03.002","article-title":"Protective effect of quercetin in primary neurons against Abeta(1\u201342): relevance to Alzheimer's disease","volume":"20","author":"Ansari","year":"2009","journal-title":"J. Nutr. Biochem."},{"key":"10.1016\/j.brainres.2022.148134_b0040","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.freeradbiomed.2014.08.025","article-title":"A time course of NADPH-oxidase up-regulation and endothelial nitric oxide synthase activation in the hippocampus following neurotrauma","volume":"77","author":"Ansari","year":"2014","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.brainres.2022.148134_b0045","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1097\/NEN.0b013e3181cb5af4","article-title":"Oxidative stress in the progression of Alzheimer disease in the frontal cortex","volume":"69","author":"Ansari","year":"2010","journal-title":"J. Neuropathol. Exp. Neurol."},{"key":"10.1016\/j.brainres.2022.148134_b0050","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/j.freeradbiomed.2011.03.025","article-title":"NADPH-oxidase activation and cognition in Alzheimer disease progression","volume":"51","author":"Ansari","year":"2011","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.brainres.2022.148134_b0055","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1042\/bj3240025","article-title":"Glutathione transferases catalyse the detoxication of oxidized metabolites (o-quinones) of catecholamines and may serve as an antioxidant system preventing degenerative cellular processes","volume":"324","author":"Baez","year":"1997","journal-title":"Biochem. J."},{"key":"10.1016\/j.brainres.2022.148134_b0060","first-page":"1243","article-title":"Chronic oral epigallocatechin-gallate alleviates streptozotocin-induced diabetic neuropathic hyperalgesia in rat: involvement of oxidative stress","volume":"11","author":"Baluchnejadmojarad","year":"2012","journal-title":"Iran. J. Pharm. Res."},{"issue":"1","key":"10.1016\/j.brainres.2022.148134_b0065","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1016\/S0006-8993(02)04091-X","article-title":"Diabetes-induced neuroendocrine changes in rats: role of brain monoamines, insulin and leptin","volume":"964","author":"Barber","year":"2003","journal-title":"Brain Res."},{"issue":"3","key":"10.1016\/j.brainres.2022.148134_b0070","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1007\/s001250051625","article-title":"Cerebral metabolism in streptozotocin-diabetic rats: an in vivo magnetic resonance spectroscopy study","volume":"44","author":"Biessels","year":"2001","journal-title":"Diabetologia"},{"key":"10.1016\/j.brainres.2022.148134_b0075","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/j.bbapap.2004.10.014","article-title":"The critical role of methionine 35 in Alzheimer's amyloid-beta-peptide (1\u201342)-induced oxidative stress and neurotoxicity","volume":"1703","author":"Butterfield","year":"2005","journal-title":"Bba-Proteins Proteom."},{"key":"10.1016\/j.brainres.2022.148134_b0080","doi-asserted-by":"crossref","first-page":"18536","DOI":"10.1074\/jbc.M413224200","article-title":"Manganese superoxide dismutase protects against 6-hydroxydopamine injury in mouse brains","volume":"280","author":"Callio","year":"2005","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.brainres.2022.148134_b0085","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1006\/bbrc.1998.8563","article-title":"The protective effect of vitamin E, idebenone and reduced glutathione on free radical mediated injury in rat brain synaptosomes","volume":"246","author":"Cardoso","year":"1998","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.brainres.2022.148134_b0090","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1002\/jbt.17","article-title":"Spatial and temporal ontogenies of glutathione peroxidase and glutathione disulfide reductase during development of the prenatal rat","volume":"15","author":"Choe","year":"2001","journal-title":"J. Biochem. Mol. Toxic."},{"key":"10.1016\/j.brainres.2022.148134_b0095","doi-asserted-by":"crossref","first-page":"114","DOI":"10.5534\/wjmh.2012.30.2.114","article-title":"Time-dependent changes of erectile function in diabetic rats: role of systemic endothelial dysfunction","volume":"30","author":"Choi","year":"2012","journal-title":"World J. Mens. Health"},{"key":"10.1016\/j.brainres.2022.148134_b0100","first-page":"131","article-title":"Slowing of motor nerve conduction velocity in streptozotocin-induced diabetic rats is preceded by impaired vasodilation in arterioles that overlie the sciatic nerve","volume":"1","author":"Coppey","year":"2000","journal-title":"Int. J. Exp. Diabetes Res."},{"key":"10.1016\/j.brainres.2022.148134_b0105","doi-asserted-by":"crossref","first-page":"1471","DOI":"10.1007\/PL00000630","article-title":"Oxidative stress and hypoxia-like injury cause Alzheimer-type molecular abnormalities in central nervous system neurons","volume":"57","author":"de la Monte","year":"2000","journal-title":"Cell. Mol. Life Sci."},{"key":"10.1016\/j.brainres.2022.148134_b0110","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1002\/jnr.20280","article-title":"Peroxide detoxification by brain cells","volume":"79","author":"Dringen","year":"2005","journal-title":"J. Neurosci. Res."},{"key":"10.1016\/j.brainres.2022.148134_b0115","doi-asserted-by":"crossref","first-page":"922","DOI":"10.1161\/01.RES.47.6.922","article-title":"Altered myocardial mechanics in diabetic rats","volume":"47","author":"Fein","year":"1980","journal-title":"Circ. Res."},{"key":"10.1016\/j.brainres.2022.148134_b0120","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1016\/S0197-4580(02)00019-2","article-title":"Oxidative stress in brain aging - Implications for therapeutics of neurodegenerative diseases","author":"Floyd","year":"2002","journal-title":"Neurobiol. Aging"},{"issue":"3","key":"10.1016\/j.brainres.2022.148134_b0125","doi-asserted-by":"crossref","first-page":"1239","DOI":"10.3892\/ijmm.2020.4653","article-title":"Troxerutin attenuates cognitive decline in the hippocampus of male diabetic rats by inhibiting NADPH oxidase and activating the Nrf2\/ARE signaling pathway","volume":"46","author":"Gao","year":"2020","journal-title":"Int. J. Mol. Med."},{"key":"10.1016\/j.brainres.2022.148134_b0130","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1016\/S0165-6147(02)02037-0","article-title":"Does insulin dysfunction play a role in Alzheimer's disease?","volume":"23","author":"Gasparini","year":"2002","journal-title":"Trends Pharmacol. Sci."},{"key":"10.1016\/j.brainres.2022.148134_b0135","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1089\/neu.2009.1181","article-title":"Age-related mitochondrial changes after traumatic brain injury","volume":"27","author":"Gilmer","year":"2010","journal-title":"J. Neurotrauma"},{"key":"10.1016\/j.brainres.2022.148134_b0140","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/j.biopha.2018.10.056","article-title":"Polyphenol-rich Boswellia serrata gum prevents cognitive impairment and insulin resistance of diabetic rats through inhibition of GSK3beta activity, oxidative stress and pro-inflammatory cytokines","volume":"109","author":"Gomaa","year":"2019","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.brainres.2022.148134_b0145","doi-asserted-by":"crossref","first-page":"1819","DOI":"10.1093\/clinchem\/41.12.1819","article-title":"Lipid-peroxidation and antioxidants as biomarkers of tissue-damage","volume":"41","author":"Gutteridge","year":"1995","journal-title":"Clin. Chem."},{"key":"10.1016\/j.brainres.2022.148134_b0150","doi-asserted-by":"crossref","first-page":"1819","DOI":"10.1093\/clinchem\/41.12.1819","article-title":"Lipid peroxidation and antioxidants as biomarkers of tissue damage","volume":"41","author":"Gutteridge","year":"1995","journal-title":"Clin. Chem."},{"key":"10.1016\/j.brainres.2022.148134_b0155","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1042\/bj2190001","article-title":"Oxygen-toxicity, oxygen radicals, transition-metals and disease","volume":"219","author":"Halliwell","year":"1984","journal-title":"Biochem. J."},{"key":"10.1016\/j.brainres.2022.148134_b0160","doi-asserted-by":"crossref","DOI":"10.1155\/2020\/3912173","article-title":"Oxymatrine ameliorates memory impairment in diabetic rats by regulating oxidative stress and apoptosis: involvement of NOX2\/NOX4","author":"Huang","year":"2020","journal-title":"Oxid. Med. Cell. Longevity"},{"issue":"1","key":"10.1016\/j.brainres.2022.148134_b0165","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.bbr.2006.03.009","article-title":"Coenzyme Q10 modulates cognitive impairment against intracerebroventricular injection of streptozotocin in rats","volume":"171","author":"Ishrat","year":"2006","journal-title":"Behav. Brain Res."},{"issue":"7","key":"10.1016\/j.brainres.2022.148134_b0170","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1097\/FBP.0b013e32832c7125","article-title":"Effects of pycnogenol and vitamin e on cognitive deficits and oxidative damage induced by intracerebroventricular streptozotocin in rats","volume":"20","author":"Ishrat","year":"2009","journal-title":"Behav. Pharmacol."},{"key":"10.1016\/j.brainres.2022.148134_b0175","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1089\/ars.2007.9.233","article-title":"Sources and targets of reactive oxygen species in synaptic plasticity and memory","volume":"9","author":"Kishida","year":"2007","journal-title":"Antioxid Redox Sign"},{"key":"10.1016\/j.brainres.2022.148134_b0180","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1016\/S1474-4422(14)70249-2","article-title":"Cognitive function in patients with diabetes mellitus: guidance for daily care","volume":"14","author":"Koekkoek","year":"2015","journal-title":"Lancet Neurol."},{"issue":"22","key":"10.1016\/j.brainres.2022.148134_b0185","doi-asserted-by":"crossref","first-page":"12158","DOI":"10.3390\/ijms222212158","article-title":"Tau cleavage contributes to cognitive dysfunction in strepto-zotocin-induced sporadic alzheimer's disease (sAD) mouse model","volume":"22","author":"Latina","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.brainres.2022.148134_b0190","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1007\/s12013-014-0200-5","article-title":"Effects of L-3-n-butylphthalide on cognitive dysfunction and NR2B expression in hippocampus of streptozotocin (STZ)-induced diabetic rats","volume":"71","author":"Li","year":"2015","journal-title":"Cell Biochem. Biophys."},{"issue":"1","key":"10.1016\/j.brainres.2022.148134_b0195","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1016\/j.bbrc.2017.11.020","article-title":"The BET\/BRD inhibitor JQ1 attenuates diabetes-induced cognitive impairment in rats by targeting Nox4-Nrf2 redox imbalance","volume":"495","author":"Liang","year":"2018","journal-title":"Biochem. Biophys. Res. Commun."},{"issue":"14","key":"10.1016\/j.brainres.2022.148134_b0200","doi-asserted-by":"crossref","first-page":"8526","DOI":"10.1073\/pnas.1332809100","article-title":"Reversal of age-related learning deficits and brain oxidative stress in mice with superoxide dismutase\/catalase mimetics","volume":"100","author":"Liu","year":"2003","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.brainres.2022.148134_b0205","doi-asserted-by":"crossref","DOI":"10.3390\/ijms20040874","article-title":"Insulin resistance and oxidative stress in the brain: what's new?","author":"Maciejczyk","year":"2019","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.brainres.2022.148134_b0210","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s10522-005-6043-0","article-title":"Neuroprotective role of neurokinin B (NKB) on beta-amyloid (25\u201335) induced toxicity in aging rat brain synaptosomes: Involvement in oxidative stress and excitotoxicity","volume":"7","author":"Mantha","year":"2006","journal-title":"Biogerontology"},{"issue":"3","key":"10.1016\/j.brainres.2022.148134_b0215","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1007\/s13105-018-0631-3","article-title":"Metabolomic analysis and biochemical changes in the urine and serum of streptozotocin-induced normal- and obese-diabetic rats","volume":"74","author":"Mediani","year":"2018","journal-title":"J. Physiol. Biochem."},{"issue":"6","key":"10.1016\/j.brainres.2022.148134_b0220","doi-asserted-by":"crossref","first-page":"1447","DOI":"10.1007\/s00125-006-0221-8","article-title":"Diabetic encephalopathy: a concept in need of a definition","volume":"49","author":"Mijnhout","year":"2006","journal-title":"Diabetologia"},{"key":"10.1016\/j.brainres.2022.148134_b0225","doi-asserted-by":"crossref","DOI":"10.1155\/2014\/102158","article-title":"Diabetes and the brain: oxidative stress, inflammation, and autophagy","volume":"2014","author":"Muriach","year":"2014","journal-title":"Oxid. Med. Cell Longev."},{"key":"10.1016\/j.brainres.2022.148134_b0230","doi-asserted-by":"crossref","first-page":"13291","DOI":"10.1074\/jbc.R900010200","article-title":"The Nrf2-antioxidant response element signaling pathway and its activation by oxidative stress","volume":"284","author":"Nguyen","year":"2009","journal-title":"J. Biol. Chem."},{"issue":"8","key":"10.1016\/j.brainres.2022.148134_b0235","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1093\/jnen\/60.8.759","article-title":"Oxidative damage is the earliest event in Alzheimer disease","volume":"60","author":"Nunomura","year":"2001","journal-title":"J. Neuropathol. Exp. Neurol."},{"key":"10.1016\/j.brainres.2022.148134_b0240","doi-asserted-by":"crossref","unstructured":"Obrosova, I.G., Fathallah, L., Liu, E. & Nourooz-Zadeh, J. Early oxidative stress in the diabetic kidney: Effect of DL-alpha-lipoic acid. Free Radical Bio Med (2003),34, 186-195. Pii S0891-5849(02)01195-410.1016\/S0891-5849(02)01195-4.","DOI":"10.1016\/S0891-5849(02)01195-4"},{"issue":"46","key":"10.1016\/j.brainres.2022.148134_b0245","doi-asserted-by":"crossref","first-page":"17326","DOI":"10.1074\/jbc.RA119.010744","article-title":"Glucoselysine is derived from fructose and accumulates in the eye lens of diabetic rats","volume":"294","author":"Ohno","year":"2019","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.brainres.2022.148134_b0250","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.acthis.2017.12.005","article-title":"Diabetes mellitus- induction: effect of different streptozotocin doses on male reproductive parameters","volume":"120","author":"Omolaoye","year":"2018","journal-title":"Acta Histochem."},{"issue":"12","key":"10.1016\/j.brainres.2022.148134_b0255","doi-asserted-by":"crossref","first-page":"2570","DOI":"10.1007\/s11064-013-1172-3","article-title":"Mitochondrial dysfunction in brain cortex mitochondria of STZ-diabetic rats: effect of l-Arginine","volume":"38","author":"Ortiz Mdel","year":"2013","journal-title":"Neurochem. Res."},{"issue":"5","key":"10.1016\/j.brainres.2022.148134_b0260","doi-asserted-by":"crossref","first-page":"798","DOI":"10.1089\/neu.2006.3673","article-title":"Post-injury administration of mitochondrial uncouplers increases tissue sparing and improves behavioral outcome following traumatic brain injury in rodents","volume":"24","author":"Pandya","year":"2007","journal-title":"J. Neurotrauma"},{"key":"10.1016\/j.brainres.2022.148134_b0265","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1016\/j.neuroscience.2005.06.027","article-title":"Excitotoxic brain damage involves early peroxynitrite formation in a model of Huntington's disease in rats: Protective role of iron porphyrinate 5,10,15,20-tetrakis (4-sulfonatophenyl)porphyrinate iron (III)","author":"Perez-de la Cruz","year":"2005","journal-title":"Neuroscience"},{"key":"10.1016\/j.brainres.2022.148134_b0270","doi-asserted-by":"crossref","first-page":"11500","DOI":"10.1002\/jcp.27808","article-title":"Protective effects of either C-peptide or l-arginine on pancreatic beta-cell function, proliferation, and oxidative stress in streptozotocin-induced diabetic rats","volume":"234","author":"Ragy","year":"2019","journal-title":"J. Cell. Physiol."},{"key":"10.1016\/j.brainres.2022.148134_b0275","doi-asserted-by":"crossref","first-page":"6507","DOI":"10.1007\/s12035-016-0169-8","article-title":"Intranasal insulin administration ameliorates streptozotocin (ICV)-induced insulin receptor dysfunction, neuroinflammation, amyloidogenesis, and memory impairment in rats","volume":"54","author":"Rajasekar","year":"2017","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.brainres.2022.148134_b0280","doi-asserted-by":"crossref","first-page":"211","DOI":"10.3233\/JAD-200658","article-title":"Thrombin signaling contributes to high glucose-induced injury of human brain microvascular endothelial cells","volume":"79","author":"Rao","year":"2021","journal-title":"J. Alzheimers Dis."},{"key":"10.1016\/j.brainres.2022.148134_b0285","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.freeradbiomed.2015.01.002","article-title":"Association of low GLP-1 with oxidative stress is related to cardiac disease and outcome in patients with type 2 diabetes mellitus: a pilot study","volume":"81","author":"Ravassa","year":"2015","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.brainres.2022.148134_b0290","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1016\/j.neuroscience.2017.06.050","article-title":"NADPH oxidase contributes to streptozotocin-induced neurodegeneration","volume":"358","author":"Ravelli","year":"2017","journal-title":"Neuroscience"},{"key":"10.1016\/j.brainres.2022.148134_b0295","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1016\/S0301-0082(98)00052-5","article-title":"Oxidative damage in the central nervous system: Protection by melatonin","volume":"56","author":"Reiter","year":"1998","journal-title":"Prog. Neurobiol."},{"issue":"12","key":"10.1016\/j.brainres.2022.148134_b0300","doi-asserted-by":"crossref","first-page":"2051","DOI":"10.1016\/j.freeradbiomed.2008.03.012","article-title":"Brain oxidative stress in a triple-transgenic mouse model of Alzheimer disease","volume":"44","author":"Resende","year":"2008","journal-title":"Free Radic. Biol. Med."},{"issue":"2","key":"10.1016\/j.brainres.2022.148134_b0305","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1006\/abbi.1999.1404","article-title":"Increased neuronal glucose-6-phosphate dehydrogenase and sulfhydryl levels indicate reductive compensation to oxidative stress in Alzheimer disease","volume":"370","author":"Russell","year":"1999","journal-title":"Arch. Biochem. Biophys."},{"key":"10.1016\/j.brainres.2022.148134_b0310","doi-asserted-by":"crossref","unstructured":"Saeedi P, Petersohn I, Salpea P, Malanda B, Karuranga S, Unwin N, Colagiuri S, Guariguata L, Motala AA, Ogurtsova K, Shaw JE, Bright D, Williams R; IDF Diabetes Atlas Committee. Global and regional diabetes prevalence estimates for 2019 and projections for 2030 and 2045: Results from the International Diabetes Federation Diabetes Atlas, 9th edition. Diabetes Res Clin Pract. (2019) 157:107843. 10.1016\/j.diabres.2019.107843.","DOI":"10.1016\/j.diabres.2019.107843"},{"key":"10.1016\/j.brainres.2022.148134_b0315","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1007\/BF00403374","article-title":"Renal proteinases and kidney hypertrophy in experimental diabetes","volume":"37","author":"Schaefer","year":"1994","journal-title":"Diabetologia"},{"key":"10.1016\/j.brainres.2022.148134_b0320","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.neurobiolaging.2016.02.030","article-title":"Oxidative stress and hippocampal synaptic protein levels in elderly cognitively intact individuals with Alzheimer's disease pathology","volume":"42","author":"Scheff","year":"2016","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.brainres.2022.148134_b0325","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1034\/j.1600-0773.2002.900505.x","article-title":"Antioxidant\/restorative effects of calcined gold preparations used in Indian systems of medicine against global and focal models of ischaemia","volume":"90","author":"Shah","year":"2002","journal-title":"Pharmacol. Toxicol."},{"key":"10.1016\/j.brainres.2022.148134_b0330","doi-asserted-by":"crossref","first-page":"694","DOI":"10.1016\/j.redox.2014.05.005","article-title":"Hyperglycaemia promotes human brain microvascular endothelial cell apoptosis via induction of protein kinase C-beta(1) and prooxidant enzyme NADPH oxidase","volume":"2","author":"Shao","year":"2014","journal-title":"Redox Biol."},{"key":"10.1016\/j.brainres.2022.148134_b0335","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1007\/s11010-013-1902-5","article-title":"Stage-specific quantitative changes in renal and urinary proteome during the progression and development of streptozotocin-induced diabetic nephropathy in rats","volume":"388","author":"Sharma","year":"2014","journal-title":"Mol. Cell. Biochem."},{"key":"10.1016\/j.brainres.2022.148134_b0340","doi-asserted-by":"crossref","first-page":"1043","DOI":"10.1016\/j.expneurol.2003.08.015","article-title":"Intracerebroventricular injection of streptozotocin causes neurotoxicity to myelin that contributes to spatial memory deficits in rats","volume":"184","author":"Shoham","year":"2003","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.brainres.2022.148134_b0345","doi-asserted-by":"crossref","first-page":"916","DOI":"10.1016\/S0891-5849(99)00177-X","article-title":"Glutathione and its role in cellular functions","volume":"27","author":"Sies","year":"1999","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.brainres.2022.148134_b0350","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1111\/jdi.12235","article-title":"Modeling type 2 diabetes in rats using high fat diet and streptozotocin","volume":"5","author":"Skovso","year":"2014","journal-title":"J. Diabetes Invest."},{"issue":"6","key":"10.1016\/j.brainres.2022.148134_b0355","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1177\/002215549804600605","article-title":"Cytochemical demonstration of oxidative damage in Alzheimer disease by immunochemical enhancement of the carbonyl reaction with 2,4-dinitrophenylhydrazine","volume":"46","author":"Smith","year":"1998","journal-title":"J. Histochem. Cytochem."},{"key":"10.1016\/j.brainres.2022.148134_b0360","doi-asserted-by":"crossref","unstructured":"Taile, J., Arcambal, A., Clerc, P., Gauvin-Bialecki, A. & Gonthier, M.P. Medicinal Plant Polyphenols Attenuate Oxidative Stress and Improve Inflammatory and Vasoactive Markers in Cerebral Endothelial Cells during Hyperglycemic Condition. Antioxidants-Basel (2020),9. ARTN 57310.3390\/antiox9070573.","DOI":"10.3390\/antiox9070573"},{"issue":"1","key":"10.1016\/j.brainres.2022.148134_b0365","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/j.mcn.2005.01.007","article-title":"Synaptic localization of a functional NADPH oxidase in the mouse hippocampus","volume":"29","author":"Tejada-Simon","year":"2005","journal-title":"Mol. Cell. Neurosci."},{"issue":"1650","key":"10.1016\/j.brainres.2022.148134_b0370","first-page":"1","article-title":"Resveratrol limits diabetes-associated cognitive decline in rats by preventing oxidative stress and inflammation and modulating hippocampal structural synaptic plasticity","volume":"1","author":"Tian","year":"2016","journal-title":"Brain Res."},{"key":"10.1016\/j.brainres.2022.148134_b0375","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1007\/s00428-003-0967-z","article-title":"Nitric oxide generation and poly(ADP ribose) polymerase activation precede beta-cell death in rats with a single high-dose injection of streptozotocin","volume":"444","author":"Wada","year":"2004","journal-title":"Virchows Arch."},{"issue":"1","key":"10.1016\/j.brainres.2022.148134_b0380","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1002\/nau.22886","article-title":"Endoplasmic reticulum stress is involved in apoptosis of detrusor muscle in streptozocin-induced diabetic rats","volume":"36","author":"Wang","year":"2017","journal-title":"Neurourol. Urodyn."},{"key":"10.1016\/j.brainres.2022.148134_b0385","doi-asserted-by":"crossref","first-page":"1055","DOI":"10.5301\/jn.5000303","article-title":"Tubular injury marker netrin-1 is elevated early in experimental diabetes","volume":"26","author":"White","year":"2013","journal-title":"J. Nephrol."},{"key":"10.1016\/j.brainres.2022.148134_b0390","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1016\/j.expneurol.2005.09.004","article-title":"Dietary curcumin counteracts the outcome of traumatic brain injury on oxidative stress, synaptic plasticity, and cognition","volume":"197","author":"Wu","year":"2006","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.brainres.2022.148134_b0395","doi-asserted-by":"crossref","first-page":"979","DOI":"10.1016\/S0891-5849(98)00186-5","article-title":"Glutathione transferase protects neuronal cultures against four hydroxynonenal toxicity","volume":"25","author":"Xie","year":"1998","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.brainres.2022.148134_b0400","doi-asserted-by":"crossref","first-page":"1773","DOI":"10.1515\/cclm.2011.250","article-title":"Oxidative stress and diabetes mellitus","volume":"49","author":"Yang","year":"2011","journal-title":"Clin. Chem. Lab. Med."},{"key":"10.1016\/j.brainres.2022.148134_b0405","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1007\/s12035-015-9666-4","article-title":"High-glucose-derived oxidative stress-dependent heme oxygenase-1 expression from astrocytes contributes to the neuronal apoptosis","volume":"54","author":"Yang","year":"2017","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.brainres.2022.148134_b0410","doi-asserted-by":"crossref","DOI":"10.1155\/2020\/4754195","article-title":"Sulforaphene ameliorates neuroinflammation and hyperphosphorylated tau protein via regulating the PI3K\/Akt\/GSK-3 beta pathway in experimental models of Alzheimer's Disease","author":"Yang","year":"2020","journal-title":"Oxid. Med. Cell. Longevity"},{"key":"10.1016\/j.brainres.2022.148134_b0415","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1016\/S0090-3019(02)01040-6","article-title":"Effects of lecithinized superoxide dismutase on neuronal cell loss in CA3 hippocampus after traumatic brain injury in rats","volume":"59","author":"Yunoki","year":"2003","journal-title":"Surg. Neurol."},{"issue":"1","key":"10.1016\/j.brainres.2022.148134_b0420","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1007\/s11011-018-0356-6","article-title":"L-3-n-butylphthalide attenuates cognitive deficits in db\/db diabetic mice","volume":"34","author":"Zhang","year":"2019","journal-title":"Metab. Brain Dis."},{"issue":"Pt A","key":"10.1016\/j.brainres.2022.148134_b0425","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/j.bbr.2016.12.046","article-title":"Inhibition of iNOS alleviates cognitive deficits and depression in diabetic mice through downregulating the NO\/sGC\/cGMP\/PKG signal pathway","volume":"322","author":"Zhou","year":"2017","journal-title":"Behav. Brain Res."}],"container-title":["Brain Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006899322003584?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006899322003584?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,13]],"date-time":"2025-09-13T18:23:58Z","timestamp":1757787838000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006899322003584"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,1]]},"references-count":85,"alternative-id":["S0006899322003584"],"URL":"https:\/\/doi.org\/10.1016\/j.brainres.2022.148134","relation":{},"ISSN":["0006-8993"],"issn-type":[{"value":"0006-8993","type":"print"}],"subject":[],"published":{"date-parts":[[2023,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Early time course of oxidative stress in hippocampal synaptosomes and cognitive loss following impaired insulin signaling in rats: Development of sporadic Alzheimer\u2019s disease","name":"articletitle","label":"Article Title"},{"value":"Brain Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.brainres.2022.148134","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"148134"}}