{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,3]],"date-time":"2026-11-03T19:57:27Z","timestamp":1793735847137,"version":"4.6.1"},"reference-count":280,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,8,1]],"date-time":"2023-08-01T00:00:00Z","timestamp":1690848000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,8,1]],"date-time":"2023-08-01T00:00:00Z","timestamp":1690848000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,8,1]],"date-time":"2023-08-01T00:00:00Z","timestamp":1690848000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2023,8,1]],"date-time":"2023-08-01T00:00:00Z","timestamp":1690848000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2023,8,1]],"date-time":"2023-08-01T00:00:00Z","timestamp":1690848000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2023,8,1]],"date-time":"2023-08-01T00:00:00Z","timestamp":1690848000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2023,8,1]],"date-time":"2023-08-01T00:00:00Z","timestamp":1690848000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000034","name":"CIHR INMHA","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000034","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000038","name":"Natural Sciences and Engineering Research Council of Canada","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000038","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Brain Research"],"published-print":{"date-parts":[[2023,8]]},"DOI":"10.1016\/j.brainres.2023.148423","type":"journal-article","created":{"date-parts":[[2023,5,25]],"date-time":"2023-05-25T13:08:15Z","timestamp":1685020095000},"page":"148423","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":12,"special_numbering":"C","title":["Putative pathological mechanisms of late-life depression and Alzheimer\u2019s disease"],"prefix":"10.1016","volume":"1813","author":[{"given":"S.M. Nageeb","family":"Hasan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Courtney","family":"Clarke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tadhg","family":"Strand","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francis R.","family":"Bambico","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.brainres.2023.148423_b0005","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1146\/annurev-physiol-020911-153336","article-title":"Small-conductance Ca2+-activated K+ channels: form and function","volume":"74","author":"Adelman","year":"2012","journal-title":"Annu. Rev. Physiol."},{"key":"10.1016\/j.brainres.2023.148423_b0010","doi-asserted-by":"crossref","first-page":"502","DOI":"10.1016\/j.eurpsy.2004.09.003","article-title":"Six-month course of mild cognitive impairment and affective symptoms in late-life depression","volume":"19","author":"Adler","year":"2004","journal-title":"Eur. Psychiatry"},{"key":"10.1016\/j.brainres.2023.148423_b0015","doi-asserted-by":"crossref","first-page":"2302","DOI":"10.1038\/jcbfm.2011.90","article-title":"SK2 channels are neuroprotective for ischemia-induced neuronal cell death","volume":"31","author":"Allen","year":"2011","journal-title":"J. Cereb. Blood Flow Metab."},{"key":"10.1016\/j.brainres.2023.148423_b0020","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1097\/01.ede.0000152116.32580.24","article-title":"Depression and the risk of Alzheimer disease","volume":"16","author":"Andersen","year":"2005","journal-title":"Epidemiology"},{"key":"10.1016\/j.brainres.2023.148423_b0025","first-page":"1031","article-title":"An overview of the links between behavioral disorders and Alzheimer\u2019disease","volume":"4","author":"Andrade","year":"2017","journal-title":"JSM Alzheimer\u2019s Dis. Relat. Dement"},{"key":"10.1016\/j.brainres.2023.148423_b0030","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/j.nbd.2010.08.020","article-title":"L-type voltage-gated calcium channel blockade with isradipine as a therapeutic strategy for Alzheimer\u2019s disease","volume":"41","author":"Anekonda","year":"2011","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.brainres.2023.148423_b0035","doi-asserted-by":"crossref","first-page":"1021","DOI":"10.1017\/S1461145710000659","article-title":"Lu AE58054, a 5-HT6 antagonist, reverses cognitive impairment induced by subchronic phencyclidine in a novel object recognition test in rats","volume":"13","author":"Arnt","year":"2010","journal-title":"Int. J. Neuropsychopharmacol."},{"issue":"3","key":"10.1016\/j.brainres.2023.148423_b0045","doi-asserted-by":"crossref","first-page":"1559","DOI":"10.1093\/cercor\/bhz187","article-title":"A key role for prefrontocortical small conductance calcium-activated potassium channels in stress adaptation and rapid antidepressant response","volume":"30","author":"Bambico","year":"2020","journal-title":"Cereb. Cortex"},{"key":"10.1016\/j.brainres.2023.148423_b0050","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1016\/j.neuropharm.2017.08.031","article-title":"Chronic treatments with a 5-HT4 receptor agonist decrease amyloid pathology in the entorhinal cortex and learning and memory deficits in the 5xFAD mouse model of Alzheimer's disease","volume":"126","author":"Baranger","year":"2017","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.brainres.2023.148423_b0055","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1016\/j.jad.2017.07.008","article-title":"Trajectories of depressive symptoms and their relationship to the progression of dementia","volume":"222","author":"Barca","year":"2017","journal-title":"J. Affect. Disord."},{"key":"10.1016\/j.brainres.2023.148423_b0060","series-title":"Monoamine Hypotheses of Mood Disorders","author":"Barchas","year":"1999"},{"key":"10.1016\/j.brainres.2023.148423_b0065","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1001\/archpsyc.63.3.273","article-title":"Depressive symptoms, vascular disease, and mild cognitive impairment: findings from the cardiovascular health study","volume":"63","author":"Barnes","year":"2006","journal-title":"Arch. Gen. Psychiatry"},{"key":"10.1016\/j.brainres.2023.148423_b0070","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/S0304-3940(98)00612-0","article-title":"Inhibition of apamin-sensitive calcium dependent potassium channels facilitate the induction of long-term potentiation in the CA1 region of rat hippocampus in vitro","volume":"253","author":"Behnisch","year":"1998","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.brainres.2023.148423_b0075","doi-asserted-by":"crossref","first-page":"1176","DOI":"10.1016\/j.neuropharm.2010.10.024","article-title":"Functional reduction of SK3-mediated currents precedes AMPA-receptor-mediated excitotoxicity in dopaminergic neurons","volume":"60","author":"Benitez","year":"2011","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.brainres.2023.148423_b0080","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1016\/j.tins.2008.06.005","article-title":"Neuronal calcium mishandling and the pathogenesis of Alzheimer\u2019s disease","volume":"31","author":"Bezprozvanny","year":"2008","journal-title":"Trends Neurosci."},{"key":"10.1016\/j.brainres.2023.148423_b0085","doi-asserted-by":"crossref","first-page":"911","DOI":"10.1038\/nn1101","article-title":"Small-conductance, Ca2+-activated K+ channel SK3 generates age-related memory and LTP deficits","volume":"6","author":"Blank","year":"2003","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.brainres.2023.148423_b0090","doi-asserted-by":"crossref","first-page":"718","DOI":"10.1038\/323718a0","article-title":"Single apamin-blocked Ca-activated K+ channels of small conductance in cultured rat skeletal muscle","volume":"323","author":"Blatz","year":"1986","journal-title":"Nature"},{"issue":"2","key":"10.1016\/j.brainres.2023.148423_b0095","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1113\/jphysiol.1973.sp010273","article-title":"Long-lasting potentiation of synaptic transmission in the dentate area of the anaesthetized rabbit following stimulation of the perforant path","volume":"232","author":"Bliss","year":"1973","journal-title":"J. Physiol."},{"key":"10.1016\/j.brainres.2023.148423_b0100","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/j.neuron.2006.12.017","article-title":"Nonlinear regulation of unitary synaptic signals by CaV(2.3) voltage-sensitive calcium channels located in dendritic spines","volume":"53","author":"Bloodgood","year":"2007","journal-title":"Neuron"},{"key":"10.1016\/j.brainres.2023.148423_b0105","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1016\/j.lfs.2010.01.013","article-title":"Involvement of potassium channels in the antidepressant-like effect of venlafaxine in mice","volume":"86","author":"Bortolatto","year":"2010","journal-title":"Life Sci."},{"key":"10.1016\/j.brainres.2023.148423_b0110","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1016\/j.bcp.2018.07.017","article-title":"Effects of n-3 PUFA enriched and n-3 PUFA deficient diets in na\u00efve and A\u03b2-treated female rats","volume":"155","author":"Bove","year":"2018","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.brainres.2023.148423_b0115","doi-asserted-by":"crossref","DOI":"10.1007\/s00213-007-0992-8","article-title":"Imbalance of a serotonergic system in frontotemporal dementia: implication for pharmacotherapy","author":"Bowen","year":"2008","journal-title":"Psychopharmacology (Berl)"},{"key":"10.1016\/j.brainres.2023.148423_b0120","doi-asserted-by":"crossref","unstructured":"Brelsford, A., Clarkson, J., Hall, J., Kidd, E. J., Thomas, R. S., Dwyer, D. & Good, M. A. 2017. Depression in a preclinical mouse model of alzheimer\u2019s disease: an age-related hedonic deficit. Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 13, P293-P294.","DOI":"10.1016\/j.jalz.2017.06.202"},{"issue":"5","key":"10.1016\/j.brainres.2023.148423_b0125","doi-asserted-by":"crossref","first-page":"716","DOI":"10.1007\/s00259-014-2975-4","article-title":"Alzheimer\u2019s disease neuroimaging initiative. Depressive symptoms accelerate cognitive decline in amyloid-positive MCI patients","volume":"42","author":"Brendel","year":"2015","journal-title":"Eur. J. Nucl. Med. Mol. Imaging"},{"key":"10.1016\/j.brainres.2023.148423_b0130","doi-asserted-by":"crossref","first-page":"897","DOI":"10.1111\/j.1476-5381.2011.01602.x","article-title":"Stress-induced anhedonia is associated with an increase in Alzheimer's disease-related markers","volume":"165","author":"Briones","year":"2012","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.brainres.2023.148423_b0135","doi-asserted-by":"crossref","unstructured":"Broe, G., Henderson, A., Creasey, H., Mccusker, E., Korten, A., Jorm, A., Longley, W. & Anthony, J. 1990. A case\u2010control study of Alzheimer's disease in Australia. Neurology, 40, 1698-1698.","DOI":"10.1212\/WNL.40.11.1698"},{"key":"10.1016\/j.brainres.2023.148423_b0140","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1037\/a0015713","article-title":"Depression as a risk factor or prodromal feature for dementia? Findings in a population-based sample of Swedish twins","volume":"24","author":"Brommelhoff","year":"2009","journal-title":"Psychol. Aging"},{"key":"10.1016\/j.brainres.2023.148423_b0145","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1017\/S1461145709990368","article-title":"CaV1.3 L-type Ca2+ channels modulate depression-like behaviour in mice independent of deaf phenotype","volume":"13","author":"Busquet","year":"2010","journal-title":"Int. J. Neuropsychopharmacol."},{"key":"10.1016\/j.brainres.2023.148423_b0150","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/j.neurobiolaging.2018.01.014","article-title":"Basal forebrain septal nuclei are enlarged in healthy subjects prior to the development of Alzheimer's disease","volume":"65","author":"Butler","year":"2018","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.brainres.2023.148423_b0155","doi-asserted-by":"crossref","first-page":"1949","DOI":"10.1176\/appi.ajp.157.12.1949","article-title":"Changes in cognitive functioning following treatment of late-life depression","volume":"157","author":"Butters","year":"2000","journal-title":"Am. J. Psychiatry"},{"key":"10.1016\/j.brainres.2023.148423_b0160","doi-asserted-by":"crossref","first-page":"8341","DOI":"10.1523\/JNEUROSCI.0936-12.2012","article-title":"Early presynaptic and postsynaptic calcium signaling abnormalities mask underlying synaptic depression in presymptomatic Alzheimer's disease mice","volume":"32","author":"Chakroborty","year":"2012","journal-title":"J. Neurosci."},{"key":"10.1016\/j.brainres.2023.148423_b0165","doi-asserted-by":"crossref","first-page":"1295","DOI":"10.1017\/S1461145714000236","article-title":"SKCblockade reverses cognitive and motor deficits induced by nigrostriatal dopamine lesions in rats","volume":"17","author":"Chen","year":"2014","journal-title":"Int. J. Neuropsychopharmacol."},{"key":"10.1016\/j.brainres.2023.148423_b0170","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1046\/j.1365-2990.2000.00254.x","article-title":"Immunocytochemical study of the dorsal and median raphe nuclei in patients with Alzheimer's disease prospectively assessed for behavioural changes","volume":"26","author":"Chen","year":"2000","journal-title":"Neuropathol. Appl. Neurobiol."},{"key":"10.1016\/j.brainres.2023.148423_b0175","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1001\/archpsyc.56.3.261","article-title":"The temporal relationship between depressive symptoms and dementia: a community-based prospective study","volume":"56","author":"Chen","year":"1999","journal-title":"Arch. Gen. Psychiatry"},{"key":"10.1016\/j.brainres.2023.148423_b0180","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1159\/000210045","article-title":"Differential impact of apathy and depression in the development of dementia in mild cognitive impairment patients","volume":"27","author":"Chilovi","year":"2009","journal-title":"Dement. Geriatr. Cogn. Disord."},{"issue":"1","key":"10.1016\/j.brainres.2023.148423_b0185","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1016\/j.expneurol.2006.07.021","article-title":"Activation of 5-HT4 receptors inhibits secretion of \u03b2-amyloid peptides and increases neuronal survival","volume":"203","author":"Cho","year":"2007","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.brainres.2023.148423_b0190","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/j.brainres.2004.05.065","article-title":"Fluoxetine inhibits A-type potassium currents in primary cultured rat hippocampal neurons","volume":"1018","author":"Choi","year":"2004","journal-title":"Brain Res."},{"issue":"1","key":"10.1016\/j.brainres.2023.148423_b0195","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s12017-009-8104-z","article-title":"An overview of APP processing enzymes and products","volume":"12","author":"Chow","year":"2010","journal-title":"NeuroMol. Med."},{"key":"10.1016\/j.brainres.2023.148423_b0200","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1016\/j.expneurol.2007.10.009","article-title":"Abeta(1\u201342) injection causes memory impairment, lowered cortical and serum BDNF levels, and decreased hippocampal 5-HT(2A) levels","volume":"210","author":"Christensen","year":"2008","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.brainres.2023.148423_b0205","doi-asserted-by":"crossref","first-page":"13592","DOI":"10.1038\/s41598-019-50018-1","article-title":"Amyloid \u03b2-induced upregulation of nav1.6 underlies neuronal hyperactivity in Tg2576 alzheimer\u2019s disease mouse model","volume":"9","author":"Ciccone","year":"2019","journal-title":"Sci. Rep."},{"key":"10.1016\/j.brainres.2023.148423_b0210","doi-asserted-by":"crossref","unstructured":"Cirrito, J. R., Disabato, B. M., Restivo, J. L., Verges, D. K., Goebel, W. D., Sathyan, A., Hayreh, D., D\u2019angelo, G., Benzinger, T., Yoon, H., Kim, J., Morris, J. C., Mintun, M. A., & Sheline, Y. I. 2011. Serotonin signaling is associated with lower amyloid-\u03b2 levels and plaques in transgenic mice and humans. Proceedings of the National Academy of Sciences of the United States of America, 108(36), 14968\u201314973.","DOI":"10.1073\/pnas.1107411108"},{"key":"10.1016\/j.brainres.2023.148423_b0215","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1021\/cn300095t","article-title":"5-HT4 receptors constitutively promote the non-amyloidogenic pathway of APP cleavage and interact with ADAM10","volume":"4","author":"Cochet","year":"2012","journal-title":"ACS Chem. Nerosci."},{"key":"10.1016\/j.brainres.2023.148423_b0220","doi-asserted-by":"crossref","first-page":"1704","DOI":"10.1111\/j.1476-5381.2010.00669.x","article-title":"Soluble beta amyloid(1\u201342): a critical player in producing behavioural and biochemical changes evoking depressive-related state?","volume":"159","author":"Colaianna","year":"2010","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.brainres.2023.148423_b0225","doi-asserted-by":"crossref","first-page":"12","DOI":"10.2174\/1874467211003010012","article-title":"Brain-derived neurotrophic factor: a dynamic gatekeeper of neural plasticity","volume":"3","author":"Cowansage","year":"2010","journal-title":"Curr. Mol. Pharmacol."},{"key":"10.1016\/j.brainres.2023.148423_b0230","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.brainres.2010.03.081","article-title":"SKC blocker apamin attenuates the effect of SSRI fluoxetine upon cell firing in dorsal raphe nucleus: a concomitant electrophysiological and electrochemical in vivo study reveals implications for modulating extracellular 5-HT","volume":"1334","author":"Crespi, f.","year":"2010","journal-title":"Brain Res."},{"key":"10.1016\/j.brainres.2023.148423_b0235","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/0197-4580(86)90019-9","article-title":"The selectivity of the reduction of serotonin S2 receptors in Alzheimer-type dementia","volume":"7","author":"Cross","year":"1986","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.brainres.2023.148423_b0240","doi-asserted-by":"crossref","first-page":"1561","DOI":"10.1016\/0028-3908(84)90100-X","article-title":"Neurotransmitter receptors and monoamine metabolites in the brains of patients with Alzheimer-type dementia and depression, and suicides","volume":"23","author":"Crow","year":"1984","journal-title":"Neuropharmacology"},{"issue":"4","key":"10.1016\/j.brainres.2023.148423_b0245","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1016\/j.neubiorev.2005.03.008","article-title":"Assessing substrates underlying the behavioral effects of antidepressants using the modified rat forced swimming test","volume":"29","author":"Cryan","year":"2005","journal-title":"Neurosci. Biobehav. Rev."},{"key":"10.1016\/j.brainres.2023.148423_b0250","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1016\/j.bbr.2011.01.005","article-title":"Chronic mild stress in mice promotes cognitive impairment and CDK5-dependent tau hyperphosphorylation","volume":"220","author":"Cuadrado-Tejedor","year":"2011","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.brainres.2023.148423_b0255","first-page":"195","article-title":"Alzheimer\u2019s disease drug development pipeline: 2018","volume":"4","author":"Cummings","year":"2018","journal-title":"Alzheimer\u2019s & Dementia: Translational Research & Clinical Interventions"},{"key":"10.1016\/j.brainres.2023.148423_b0260","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1186\/alzrt269","article-title":"Alzheimer\u2019s disease drug-development pipeline: few candidates, frequent failures","volume":"6","author":"Cummings","year":"2014","journal-title":"Alzheimers Res. Ther."},{"key":"10.1016\/j.brainres.2023.148423_b0265","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1038\/nrn2297","article-title":"From inflammation to sickness and depression: when the immune system subjugates the brain","volume":"9","author":"Dantzer","year":"2008","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.brainres.2023.148423_b0270","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1590\/S1980-57642011DN05010003","article-title":"Effects of stress hormones on the brain and cognition: evidence from normal to pathological aging","volume":"5","author":"De Souza-Talarico","year":"2011","journal-title":"Dement Neuropsychol"},{"issue":"Suppl 6","key":"10.1016\/j.brainres.2023.148423_b0275","first-page":"7","article-title":"Depression: the case for a monoamine deficiency","volume":"61","author":"Delgado","year":"2000","journal-title":"J. Clin. Psychiatry"},{"key":"10.1016\/j.brainres.2023.148423_b0280","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/S0304-3940(97)13367-5","article-title":"Apamin improves learning in an object recognition task in rats","volume":"222","author":"Deschaux","year":"1997","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.brainres.2023.148423_b0285","doi-asserted-by":"crossref","first-page":"905","DOI":"10.3945\/an.116.012187","article-title":"Omega-3 polyunsaturated fatty acids and oxylipins in neuroinflammation and management of alzheimer disease","volume":"7","author":"Devassy","year":"2016","journal-title":"Adv. Nutr."},{"key":"10.1016\/j.brainres.2023.148423_b0290","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1007\/BF02260900","article-title":"5-HT 2 receptors in dementia of the Alzheimer type: A quantitative autoradiographic study of frontal cortex and hippocampus","volume":"2","author":"Dewar","year":"1990","journal-title":"J. Neural Transmission-Parkinson's Disease and Dementia Section"},{"key":"10.1016\/j.brainres.2023.148423_b0295","doi-asserted-by":"crossref","first-page":"1443","DOI":"10.2147\/NDT.S47133","article-title":"Behavioral symptoms related to cognitive impairment","volume":"9","author":"Dillon","year":"2013","journal-title":"Neuropsychiatr. Dis. Treat."},{"key":"10.1016\/j.brainres.2023.148423_b0300","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1192\/bjp.bp.112.118307","article-title":"Late-life depression and risk of vascular dementia and Alzheimer's disease: systematic review and meta-analysis of community-based cohort studies","volume":"202","author":"Diniz","year":"2013","journal-title":"Br. J. Psychiatry"},{"issue":"1","key":"10.1016\/j.brainres.2023.148423_b0305","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1186\/s12974-019-1453-0","article-title":"Exploiting microglial and peripheral immune cell crosstalk to treat Alzheimer\u2019s disease","volume":"16","author":"Dionisio-Santos","year":"2019","journal-title":"J. Neuroinflammation"},{"key":"10.1016\/j.brainres.2023.148423_b0310","doi-asserted-by":"crossref","first-page":"196","DOI":"10.3389\/fphar.2012.00196","article-title":"Protective roles for potassium SK\/KCa2 channels in microglia and neurons","volume":"3","author":"Dolga","year":"2012","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.brainres.2023.148423_b0315","doi-asserted-by":"crossref","first-page":"1158","DOI":"10.1111\/j.1471-4159.2008.05701.x","article-title":"TNF-alpha-mediates neuroprotection against glutamate-induced excitotoxicity via NF-kappaB-dependent up-regulation of K2.2 channels","volume":"107","author":"Dolga","year":"2008","journal-title":"J. Neurochem."},{"key":"10.1016\/j.brainres.2023.148423_b0320","doi-asserted-by":"crossref","first-page":"e147","DOI":"10.1038\/cddis.2011.30","article-title":"KCa2 channels activation prevents [Ca2+]i deregulation and reduces neuronal death following glutamate toxicity and cerebral ischemia","volume":"2","author":"Dolga","year":"2011","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.brainres.2023.148423_b0325","doi-asserted-by":"crossref","first-page":"2050","DOI":"10.1002\/glia.22419","article-title":"Activation of KCNN3\/SK3\/K(Ca)2.3 channels attenuates enhanced calcium influx and inflammatory cytokine production in activated microglia","volume":"60","author":"Dolga","year":"2012","journal-title":"Glia"},{"key":"10.1016\/j.brainres.2023.148423_b0330","doi-asserted-by":"crossref","first-page":"10792","DOI":"10.1074\/jbc.M113.453522","article-title":"Mitochondrial small conductance SK2 channels prevent glutamate-induced oxytosis and mitochondrial dysfunction","volume":"288","author":"Dolga","year":"2013","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.brainres.2023.148423_b0335","doi-asserted-by":"crossref","first-page":"e999","DOI":"10.1038\/cddis.2013.530","article-title":"Subcellular expression and neuroprotective effects of SK channels in human dopaminergic neurons","volume":"5","author":"Dolga","year":"2014","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.brainres.2023.148423_b0340","doi-asserted-by":"crossref","first-page":"63","DOI":"10.3233\/JAD-142940","article-title":"Depressive symptoms and biomarkers of alzheimer's disease in cognitively normal older adults","volume":"46","author":"Donovan","year":"2015","journal-title":"J. Alzheimers Dis."},{"key":"10.1016\/j.brainres.2023.148423_b0345","doi-asserted-by":"crossref","first-page":"530","DOI":"10.1176\/appi.ajp.2017.17040442","article-title":"Longitudinal association of amyloid beta and anxious-depressive symptoms in cognitively normal older adults","volume":"175","author":"Donovan","year":"2018","journal-title":"Am. J. Psychiatry"},{"key":"10.1016\/j.brainres.2023.148423_b0350","first-page":"32","article-title":"Is dysregulation of the HPA-axis a core pathophysiology mediating co-morbid depression in neurodegenerative diseases?","volume":"6","author":"Du","year":"2015","journal-title":"Front. Psych."},{"issue":"Suppl 1","key":"10.1016\/j.brainres.2023.148423_b0355","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1111\/jnc.13572","article-title":"Converging roles of ion channels, calcium, metabolic stress, and activity pattern of Substantia nigra dopaminergic neurons in health and Parkinson's disease","volume":"139","author":"Duda","year":"2016","journal-title":"J. Neurochem."},{"key":"10.1016\/j.brainres.2023.148423_b0360","doi-asserted-by":"crossref","first-page":"634","DOI":"10.1093\/oxfordjournals.aje.a008974","article-title":"Longitudinal analysis of the association between depressive symptomatology and cognitive deterioration","volume":"144","author":"Dufouil","year":"1996","journal-title":"Am. J. Epidemiol."},{"key":"10.1016\/j.brainres.2023.148423_b0365","doi-asserted-by":"crossref","first-page":"590","DOI":"10.1038\/nchembio.1547","article-title":"Cdk5 induces constitutive activation of 5-HT6 receptors to promote neurite growth","volume":"10","author":"Duhr","year":"2014","journal-title":"Nat. Chem. Biol."},{"key":"10.1016\/j.brainres.2023.148423_b0370","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.brainres.2005.08.004","article-title":"Altered depression-related behavior and neurochemical changes in serotonergic neurons in mutant R406W human tau transgenic mice","volume":"1059","author":"Egashira","year":"2005","journal-title":"Brain Res."},{"key":"10.1016\/j.brainres.2023.148423_b0375","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1186\/1750-1326-8-2","article-title":"Neuron loss in the 5XFAD mouse model of Alzheimer\u2019s disease correlates with intraneuronal A\u03b242 accumulation and Caspase-3 activation","volume":"8","author":"Eimer","year":"2013","journal-title":"Mol. Neurodegeneration"},{"issue":"3","key":"10.1016\/j.brainres.2023.148423_b0380","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1016\/j.pnpbp.2003.11.018","article-title":"Central monoamines and their role in major depression","volume":"28","author":"Elhwuegi","year":"2004","journal-title":"Prog. Neuropsychopharmacol. Biol. Psychiatry"},{"key":"10.1016\/j.brainres.2023.148423_b0385","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/j.brainresbull.2018.01.001","article-title":"ATP-sensitive potassium-channel inhibitor glibenclamide attenuates HPA axis hyperactivity, depression- and anxiety-related symptoms in a rat model of Alzheimer's disease","volume":"137","author":"Esmaeili","year":"2018","journal-title":"Brain Res. Bull."},{"issue":"3","key":"10.1016\/j.brainres.2023.148423_b0390","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1007\/s12013-009-9062-7","article-title":"Functions and modulation of neuronal SK channels","volume":"55","author":"Faber","year":"2009","journal-title":"Cell Biochem. Biophys."},{"key":"10.1016\/j.brainres.2023.148423_b0400","doi-asserted-by":"crossref","first-page":"1077","DOI":"10.1111\/j.1440-1681.2007.04725.x","article-title":"Functions of SKCs in central neurons","volume":"34","author":"Faber","year":"2007","journal-title":"Clin. Exp. Pharmacol. Physiol."},{"key":"10.1016\/j.brainres.2023.148423_b0405","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1038\/nn1450","article-title":"SKCs regulate excitatory synaptic transmission and plasticity in the lateral amygdala","volume":"8","author":"Faber","year":"2005","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.brainres.2023.148423_b0410","doi-asserted-by":"crossref","first-page":"17548","DOI":"10.1073\/pnas.0607914103","article-title":"SKCs mediate NADPH oxidase-independent reactive oxygen species production and apoptosis in granulocytes","volume":"103","author":"Fay","year":"2006","journal-title":"PNAS"},{"key":"10.1016\/j.brainres.2023.148423_b0415","doi-asserted-by":"crossref","first-page":"1199","DOI":"10.1212\/01.WNL.0000118301.92105.EE","article-title":"Behavioral symptoms in mild cognitive impairment","volume":"62","author":"Feldman","year":"2004","journal-title":"Neurology"},{"key":"10.1016\/j.brainres.2023.148423_b0420","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1186\/1471-2377-10-87","article-title":"A.L.M.C.S.Behavioural symptoms in patients with Alzheimer's disease and their association with cognitive impairment","volume":"10","author":"Fernandez","year":"2010","journal-title":"BMC Neurol."},{"key":"10.1016\/j.brainres.2023.148423_b0425","doi-asserted-by":"crossref","first-page":"101","DOI":"10.2174\/1570159X13666150716165726","article-title":"Alzheimer's disease: targeting the Cholinergic System","volume":"14","author":"Ferreira-Vieira","year":"2016","journal-title":"Curr. Neuropharmacol."},{"key":"10.1016\/j.brainres.2023.148423_b0430","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1007\/s40263-016-0399-3","article-title":"Serotonin 5-HT6 receptor antagonists in alzheimer's disease: therapeutic rationale and current development status","volume":"31","author":"Ferrero","year":"2017","journal-title":"CNS Drugs"},{"key":"10.1016\/j.brainres.2023.148423_b0435","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1111\/j.1601-183X.2008.00453.x","article-title":"Cognitive and non-cognitive behaviors in an APPswe\/PS1 bigenic model of Alzheimer's disease","volume":"8","author":"Filali","year":"2009","journal-title":"Genes Brain Behav."},{"issue":"1","key":"10.1016\/j.brainres.2023.148423_b0440","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1186\/s13024-016-0112-5","article-title":"Redundant Gs-coupled serotonin receptors regulate amyloid-\u03b2 metabolism in vivo","volume":"11","author":"Fisher","year":"2016","journal-title":"Mol. Neurodegener."},{"key":"10.1016\/j.brainres.2023.148423_b0445","doi-asserted-by":"crossref","first-page":"1015","DOI":"10.1016\/j.neuropharm.2008.06.061","article-title":"An update on the role of the 5-hydroxytryptamine6 receptor in cognitive function","volume":"55","author":"Fone","year":"2008","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.brainres.2023.148423_b0450","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1136\/jnnp.66.2.137","article-title":"The cholinergic hypothesis of Alzheimer\u2019s disease: a review of progress","volume":"66","author":"Francis","year":"1999","journal-title":"J. Neurol. Neurosurg. Psychiatry"},{"key":"10.1016\/j.brainres.2023.148423_b0455","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1093\/oxfordjournals.aje.a114013","article-title":"A case-control study of dementia of the Alzheimer type","volume":"121","author":"French","year":"1985","journal-title":"Am. J. Epidemiol."},{"key":"10.1016\/j.brainres.2023.148423_b0460","doi-asserted-by":"crossref","first-page":"1168","DOI":"10.1002\/gps.1235","article-title":"Prevalence of major and minor depression in elderly persons with mild cognitive impairment\u2013MADRS factor analysis","volume":"19","author":"Gabryelewicz","year":"2004","journal-title":"Int. J. Geriatr. Psychiatry"},{"key":"10.1016\/j.brainres.2023.148423_b0465","doi-asserted-by":"crossref","first-page":"1653","DOI":"10.1038\/sj.bjp.0702467","article-title":"Effect of potassium channel modulators in mouse forced swimming test","volume":"126","author":"Galeotti","year":"1999","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.brainres.2023.148423_b0470","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1016\/j.jagp.2018.05.002","article-title":"Depression and risk of alzheimer dementia: a longitudinal analysis to determine predictors of increased risk among older adults with depression","volume":"26","author":"Gallagher","year":"2018","journal-title":"Am. J. Geriatr. Psychiatry"},{"key":"10.1016\/j.brainres.2023.148423_b0475","doi-asserted-by":"crossref","first-page":"79","DOI":"10.3389\/fnbeh.2018.00079","article-title":"Immediate early genes, memory and psychiatric disorders: focus on c-Fos, Egr1 and Arc","volume":"12","author":"Gallo","year":"2018","journal-title":"Front. Behav. Neurosci."},{"key":"10.1016\/j.brainres.2023.148423_b0480","doi-asserted-by":"crossref","unstructured":"Garcia, R., Alvarado, L., Dwivedi, A., & Salazar, R. 2020. History of depression as a risk factor for the diagnosis of dementia: a retrospective case-control study. The American Journal of Geriatric Psychiatry, 28(4), S72\u2013S74.","DOI":"10.1016\/j.jagp.2020.01.099"},{"key":"10.1016\/j.brainres.2023.148423_b0485","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1016\/j.neuropsychologia.2004.06.007","article-title":"Cholinergic-serotonergic imbalance contributes to cognitive and behavioral symptoms in Alzheimer\u2019s disease","volume":"43","author":"Garcia-Alloza","year":"2005","journal-title":"Neuropsychologia"},{"key":"10.1016\/j.brainres.2023.148423_b0490","doi-asserted-by":"crossref","first-page":"975","DOI":"10.3233\/JAD-170001","article-title":"Depressive symptoms and tau accumulation in the inferior temporal lobe and entorhinal cortex in cognitively normal older adults: a pilot study","volume":"59","author":"Gatchel","year":"2017","journal-title":"J. Alzheimers Dis."},{"issue":"8","key":"10.1016\/j.brainres.2023.148423_b0495","doi-asserted-by":"crossref","first-page":"e198964","DOI":"10.1001\/jamanetworkopen.2019.8964","article-title":"Longitudinal association of depression symptoms with cognition and cortical amyloid among community-dwelling older adults","volume":"2","author":"Gatchel","year":"2019","journal-title":"JAMA Netw. Open"},{"issue":"6","key":"10.1016\/j.brainres.2023.148423_b0500","doi-asserted-by":"crossref","first-page":"568","DOI":"10.1192\/bjp.176.6.568","article-title":"Depression and risk of cognitive decline and Alzheimer\u2019s disease: results of two prospective community-based studies in the Netherlands","volume":"176","author":"Geerlings","year":"2000","journal-title":"Br. J. Psychiatry"},{"key":"10.1016\/j.brainres.2023.148423_b0505","doi-asserted-by":"crossref","first-page":"765","DOI":"10.2165\/11590190-000000000-00000","article-title":"Role of serotonin in Alzheimer's disease: a new therapeutic target?","volume":"25","author":"Geldenhuys","year":"2011","journal-title":"CNS Drugs"},{"key":"10.1016\/j.brainres.2023.148423_b0510","first-page":"33","article-title":"Disturbance of the 5-hydroxytryptamine metabolism in brains from patients with Alzheimer\u2019s dementia. Neurotransmitter and Dementia","volume":"30","author":"Gottfries.","year":"1990","journal-title":"J. Neural Transm. Suppl."},{"key":"10.1016\/j.brainres.2023.148423_b0515","doi-asserted-by":"crossref","first-page":"12128","DOI":"10.1523\/JNEUROSCI.2474-10.2010","article-title":"NMDA-mediated Ca(2+) influx drives aberrant ryanodine receptor activation in dendrites of young Alzheimer's disease mice","volume":"30","author":"Goussakov","year":"2010","journal-title":"J. Neurosci."},{"issue":"1","key":"10.1016\/j.brainres.2023.148423_b0520","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1111\/j.1532-5415.2010.03233.x","article-title":"Depressive symptoms and incidence of mild cognitive impairment and probable dementia in elderly women: the Women\u2019s Health Initiative Memory Study","volume":"59","author":"Goveas","year":"2011","journal-title":"J. Am. Geriatr. Soc."},{"key":"10.1016\/j.brainres.2023.148423_b0525","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1101\/gad.1256405","article-title":"The role of the Rho GTPases in neuronal development","volume":"19","author":"Govek","year":"2005","journal-title":"Genes Dev."},{"key":"10.1016\/j.brainres.2023.148423_b0530","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1001\/archneur.60.5.753","article-title":"Depression as a risk factor for Alzheimer disease: the MIRAGE Study","volume":"60","author":"Green","year":"2003","journal-title":"Arch. Neurol."},{"key":"10.1016\/j.brainres.2023.148423_b0535","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1111\/j.1365-2990.2008.00997.x","article-title":"The dorsal raphe nucleus shows phospho-tau neurofibrillary changes before the transentorhinal region in Alzheimer's disease. A precocious onset?","volume":"35","author":"Grinberg","year":"2009","journal-title":"Neuropathol. Appl. Neurobiol."},{"key":"10.1016\/j.brainres.2023.148423_b0540","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.bbr.2018.06.032","article-title":"Agmatine attenuates depressive-like behavior and hippocampal oxidative stress following amyloid beta (Abeta1-40) administration in mice","volume":"353","author":"Guerra de souza","year":"2018","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.brainres.2023.148423_b0545","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/j.nlm.2016.06.014","article-title":"The serotonergic 5-HT4 receptor: a unique modulator of hippocampal synaptic information processing and cognition","volume":"138","author":"Hagena","year":"2017","journal-title":"Neurobiol. Learn. Mem."},{"key":"10.1016\/j.brainres.2023.148423_b0550","doi-asserted-by":"crossref","first-page":"1844","DOI":"10.1523\/JNEUROSCI.4106-05.2006","article-title":"Small-conductance Ca2+-activated K+ channel type 2 (SK2) modulates hippocampal learning, memory, and synaptic plasticity","volume":"26","author":"Hammond","year":"2006","journal-title":"J. Neurosci."},{"issue":"5054","key":"10.1016\/j.brainres.2023.148423_b0555","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1126\/science.1566067","article-title":"Alzheimer\u2019s disease: the amyloid cascade hypothesis","volume":"256","author":"Hardy","year":"1992","journal-title":"Science"},{"key":"10.1016\/j.brainres.2023.148423_b0560","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1002\/gps.4489","article-title":"Amyloid burden and incident depressive symptoms in cognitively normal older adults","volume":"32","author":"Harrington","year":"2017","journal-title":"Int. J. Geriatr. Psychiatry"},{"key":"10.1016\/j.brainres.2023.148423_b0565","doi-asserted-by":"crossref","first-page":"233","DOI":"10.3389\/fnagi.2019.00233","article-title":"Microglia in alzheimer disease: well-known targets and new opportunities","volume":"11","author":"Hemonnot","year":"2019","journal-title":"Front. Aging Neurosci."},{"key":"10.1016\/j.brainres.2023.148423_b0570","first-page":"9","article-title":"Brain-derived neurotrophic factor: three ligands, many actions","volume":"126","author":"Hempstead.","year":"2015","journal-title":"Trans. Am. Clin. Climatol. Assoc."},{"key":"10.1016\/j.brainres.2023.148423_b0575","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1017\/S0033291796004199","article-title":"The course of depression in the elderly: a longitudinal community-based study in Australia","volume":"27","author":"Henderson","year":"1997","journal-title":"Psychol. Med."},{"key":"10.1016\/j.brainres.2023.148423_b0580","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1016\/S1474-4422(15)70016-5","article-title":"Neuroinflammation in Alzheimer's disease","volume":"14","author":"Heneka","year":"2015","journal-title":"Lancet Neurol."},{"key":"10.1016\/j.brainres.2023.148423_b0585","doi-asserted-by":"crossref","first-page":"11","DOI":"10.3389\/fphar.2012.00011","article-title":"CyPPA, a positive SK3\/SK2 modulator, reduces activity of dopaminergic neurons, inhibits dopamine release, and counteracts hyperdopaminergic behaviors induced by methylphenidate","volume":"3","author":"Herrik","year":"2012","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.brainres.2023.148423_b0590","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/0169-328X(93)90169-P","article-title":"Memory processing and apamin induce immediate early gene expression in mouse brain","volume":"18","author":"Heurteaux","year":"1993","journal-title":"Brain Res. Mol. Brain Res."},{"key":"10.1016\/j.brainres.2023.148423_b0595","doi-asserted-by":"crossref","first-page":"1201","DOI":"10.3233\/JAD-2010-100117","article-title":"Plaque deposition dependent decrease in 5-HT2A serotonin receptor in AbetaPPswe\/PS1dE9 amyloid overexpressing mice","volume":"20","author":"Holm","year":"2010","journal-title":"J. Alzheimers Dis."},{"issue":"1","key":"10.1016\/j.brainres.2023.148423_b0600","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1002\/ajmg.b.10068","article-title":"Depression in Alzheimer\u2019s disease: the effect of serotonin receptor gene variation","volume":"119B","author":"Holmes","year":"2003","journal-title":"Am. J. Med. Genet. B Neuropsychiatr. Genet."},{"key":"10.1016\/j.brainres.2023.148423_b0605","doi-asserted-by":"crossref","first-page":"e46464","DOI":"10.7554\/eLife.46464","article-title":"Molecular and anatomical organization of the dorsal raphe nucleus","volume":"8","author":"Huang","year":"2019","journal-title":"Elife"},{"key":"10.1016\/j.brainres.2023.148423_b0610","doi-asserted-by":"crossref","first-page":"e79651","DOI":"10.1371\/journal.pone.0079651","article-title":"Impairments in neurogenesis are not tightly linked to depressive behavior in a transgenic mouse model of Alzheimer's disease","volume":"8","author":"Iascone","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.brainres.2023.148423_b0615","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/S0014-2999(99)00616-0","article-title":"Effects of apamin on memory processing of hippocampal-lesioned mice","volume":"382","author":"Ikonen","year":"1999","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.brainres.2023.148423_b0620","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/S0014-2999(98)00075-2","article-title":"Apamin improves spatial navigation in medial septal-lesioned mice","volume":"347","author":"Ikonen","year":"1998","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.brainres.2023.148423_b0625","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/S0014-2999(00)00736-6","article-title":"The effects of some K(+) channel blockers on scopolamine- or electroconvulsive shock-induced amnesia in mice","volume":"407","author":"Inan","year":"2000","journal-title":"Eur. J. Pharmacol."},{"issue":"1","key":"10.1016\/j.brainres.2023.148423_b0630","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1001\/jamapsychiatry.2016.3162","article-title":"Prevalence of depression in patients with mild cognitive impairment: a systematic review and meta-analysis","volume":"74","author":"Ismail","year":"2017","journal-title":"JAMA Psychiat."},{"key":"10.1016\/j.brainres.2023.148423_b0635","doi-asserted-by":"crossref","first-page":"836","DOI":"10.1111\/j.1601-183X.2008.00416.x","article-title":"SK3 K+ channel-deficient mice have enhanced dopamine and serotonin release and altered emotional behaviors","volume":"7","author":"Jacobsen","year":"2008","journal-title":"Genes Brain Behav."},{"key":"10.1016\/j.brainres.2023.148423_b0640","doi-asserted-by":"crossref","first-page":"1471","DOI":"10.4103\/1673-5374.191222","article-title":"Serotonin regulates brain-derived neurotrophic factor expression in select brain regions during acute psychological stress","volume":"11","author":"Jiang","year":"2016","journal-title":"Neural Regen. Res."},{"issue":"5","key":"10.1016\/j.brainres.2023.148423_b0645","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1016\/j.neuron.2008.04.010","article-title":"ApoE promotes the proteolytic degradation of A\u03b2","volume":"58","author":"Jiang","year":"2008","journal-title":"Neuron"},{"issue":"1","key":"10.1016\/j.brainres.2023.148423_b0650","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1146\/annurev.pa.30.040190.003423","article-title":"Neuropharmacology of phencyclidine: basic mechanisms and therapeutic potential","volume":"30","author":"Johnson","year":"1990","journal-title":"Annu. Rev. Pharmacol. Toxicol."},{"issue":"6","key":"10.1016\/j.brainres.2023.148423_b0655","doi-asserted-by":"crossref","first-page":"776","DOI":"10.1046\/j.1440-1614.2001.00967.x","article-title":"History of depression as a risk factor for dementia: an updated review","volume":"35","author":"Jorm","year":"2001","journal-title":"Aust. N. Z. J. Psychiatry"},{"key":"10.1016\/j.brainres.2023.148423_b0660","doi-asserted-by":"crossref","unstructured":"Jorm, A., Van Duijn, C., Chandra, V., Fratiglioni, L., Graves, A., Heyman, A., Kokmen, E., Kondo, K., Mortimer, J. & Rocca, W. A. 1991. Psychiatric history and related exposures as risk factors for Alzheimer's disease: a collaborative re-analysis of case-control studies. International journal of epidemiology, 20, S43-S47.","DOI":"10.1093\/ije\/20.Supplement_2.S43"},{"key":"10.1016\/j.brainres.2023.148423_b0665","doi-asserted-by":"crossref","DOI":"10.1136\/bmj.h369","article-title":"Assessment and management of behavioral and psychological symptoms of dementia","volume":"350","author":"Kales","year":"2015","journal-title":"BMJ"},{"key":"10.1016\/j.brainres.2023.148423_b0670","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1016\/j.bbr.2005.06.031","article-title":"Effects of potassium channel inhibitors in the forced swimming test: Possible involvement of l-arginine-nitric oxide-soluble guanylate cyclase pathway","volume":"165","author":"Kaster","year":"2005","journal-title":"Behav. Brain Res."},{"issue":"5","key":"10.1016\/j.brainres.2023.148423_b0675","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1001\/jamapsychiatry.2016.0004","article-title":"Trajectories of depressive symptoms in older adults and risk of dementia","volume":"73","author":"Kaup","year":"2016","journal-title":"JAMA Psychiat."},{"key":"10.1016\/j.brainres.2023.148423_b0680","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1523\/JNEUROSCI.3593-06.2007","article-title":"The Ca2+-activated K+ channel KCNN4\/KCa3.1 contributes to microglia activation and nitric oxide-dependent neurodegeneration","volume":"27","author":"Kaushal","year":"2007","journal-title":"J. Neurosci."},{"key":"10.1016\/j.brainres.2023.148423_b0685","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1016\/j.nbd.2014.07.001","article-title":"Disease modifying effect of chronic oral treatment with a neurotrophic peptidergic compound in a triple transgenic mouse model of Alzheimer's disease","volume":"71","author":"Kazim","year":"2014","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.brainres.2023.148423_b0690","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1007\/s00213-010-1854-3","article-title":"E-6801, a 5-HT6 receptor agonist, improves recognition memory by combined modulation of cholinergic and glutamatergic neurotransmission in the rat","volume":"213","author":"Kendall","year":"2011","journal-title":"Psychopharmacology"},{"key":"10.1016\/j.brainres.2023.148423_b0695","doi-asserted-by":"crossref","first-page":"702","DOI":"10.1073\/pnas.0510237103","article-title":"Serotonin 1A receptors in the living brain of Alzheimer's disease patients","volume":"103","author":"Kepe","year":"2006","journal-title":"PNAS"},{"key":"10.1016\/j.brainres.2023.148423_b0700","doi-asserted-by":"crossref","unstructured":"Kokmen, E., Beard, C., Chandra, V., Offord, K., Schoenberg, B. & Ballard, D. 1991. Clinical risk factors for Alzheimer's disease A population\u2010based case\u2010control study. Neurology, 41, 1393-1393.","DOI":"10.1212\/WNL.41.9.1393"},{"key":"10.1016\/j.brainres.2023.148423_b0705","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1097\/00001756-200301200-00014","article-title":"Nucleus-specific alteration of raphe neurons in human neurodegenerative disorders","volume":"14","author":"Kovacs","year":"2003","journal-title":"Neuroreport"},{"key":"10.1016\/j.brainres.2023.148423_b0710","doi-asserted-by":"crossref","first-page":"5151","DOI":"10.1523\/JNEUROSCI.0800-04.2004","article-title":"A novel mechanism for the facilitation of theta-induced long-term potentiation by brain-derived neurotrophic factor","volume":"24","author":"Kramar","year":"2004","journal-title":"J. Neurosci."},{"key":"10.1016\/j.brainres.2023.148423_b0715","doi-asserted-by":"crossref","first-page":"894","DOI":"10.1038\/nature07455","article-title":"The molecular neurobiology of depression","volume":"455","author":"Krishnan","year":"2008","journal-title":"Nature"},{"key":"10.1016\/j.brainres.2023.148423_b0720","doi-asserted-by":"crossref","first-page":"1143","DOI":"10.1001\/archgenpsychiatry.2011.122","article-title":"Protein binding in patients with late-life depression","volume":"68","author":"Kumar","year":"2011","journal-title":"Arch. Gen. Psychiatry"},{"key":"10.1016\/j.brainres.2023.148423_b0725","doi-asserted-by":"crossref","first-page":"7821","DOI":"10.1523\/JNEUROSCI.1790-05.2005","article-title":"5-HT7 receptor is coupled to G alpha subunits of heterotrimeric G12-protein to regulate gene transcription and neuronal morphology","volume":"25","author":"Kvachnina","year":"2005","journal-title":"J. Neurosci."},{"key":"10.1016\/j.brainres.2023.148423_b0730","doi-asserted-by":"crossref","first-page":"862","DOI":"10.1038\/nrn960","article-title":"Calcium dyshomeostasis and intracellular signalling in Alzheimer's disease","volume":"3","author":"Laferla","year":"2002","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.brainres.2023.148423_b0735","doi-asserted-by":"crossref","first-page":"1175","DOI":"10.1097\/00001756-200207020-00021","article-title":"Postmortem serotoninergic correlates of cognitive decline in Alzheimer's disease","volume":"13","author":"Lai","year":"2002","journal-title":"Neuroreport"},{"key":"10.1016\/j.brainres.2023.148423_b0740","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1016\/S0006-8993(03)02554-X","article-title":"Reduced serotonin 5-HT1A receptor binding in the temporal cortex correlates with aggressive behavior in Alzheimer disease","volume":"974","author":"Lai","year":"2003","journal-title":"Brain Res."},{"key":"10.1016\/j.brainres.2023.148423_b0745","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1007\/s00213-004-2077-2","article-title":"Loss of serotonin 5-HT2A receptors in the postmortem temporal cortex correlates with rate of cognitive decline in Alzheimer's disease","volume":"179","author":"Lai","year":"2005","journal-title":"Psychopharmacology"},{"key":"10.1016\/j.brainres.2023.148423_b0750","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1007\/s00213-010-1936-2","article-title":"Differential involvement of hippocampal serotonin1A receptors and re-uptake sites in non-cognitive behaviors of Alzheimer's disease","volume":"213","author":"Lai","year":"2011","journal-title":"Psychopharmacology"},{"key":"10.1016\/j.brainres.2023.148423_b0755","doi-asserted-by":"crossref","first-page":"1203","DOI":"10.1517\/14728222.2013.823161","article-title":"The therapeutic potential of small-conductance KCa2 channels in neurodegenerative and psychiatric diseases","volume":"17","author":"Lam","year":"2013","journal-title":"Expert Opin. Ther. Targets"},{"key":"10.1016\/j.brainres.2023.148423_b0760","doi-asserted-by":"crossref","first-page":"809","DOI":"10.1111\/j.1469-7793.2001.00809.x","article-title":"Interaction between synaptic excitation and slow afterhyperpolarization current in rat hippocampal pyramidal cells","volume":"536","author":"Lancaster","year":"2001","journal-title":"J. Physiol."},{"issue":"6","key":"10.1016\/j.brainres.2023.148423_b0765","doi-asserted-by":"crossref","first-page":"1215","DOI":"10.1046\/j.1471-4159.2003.01615.x","article-title":"Expanding the association between the APOE gene and the risk of Alzheimer\u2019s disease: Possible roles for APOE promoter polymorphisms and alterations in APOE transcription","volume":"84","author":"Laws","year":"2003","journal-title":"J. Neurochem."},{"key":"10.1016\/j.brainres.2023.148423_b0770","doi-asserted-by":"crossref","first-page":"1053","DOI":"10.1038\/mp.2012.168","article-title":"Amyloid-beta oligomers link depressive-like behavior and cognitive deficits in mice","volume":"18","author":"Ledo","year":"2013","journal-title":"Mol. Psychiatry"},{"key":"10.1016\/j.brainres.2023.148423_b0775","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1017\/S1041610206003607","article-title":"Persistent mild cognitive impairment in geriatric depression","volume":"19","author":"Lee","year":"2007","journal-title":"Int. Psychogeriatr."},{"key":"10.1016\/j.brainres.2023.148423_b0780","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1097\/WNR.0000000000000362","article-title":"Brainstem morphological changes in Alzheimer's disease","volume":"26","author":"Lee","year":"2015","journal-title":"Neuroreport"},{"key":"10.1016\/j.brainres.2023.148423_b0785","doi-asserted-by":"crossref","first-page":"2304","DOI":"10.1523\/JNEUROSCI.4162-03.2004","article-title":"Phosphorylation of tau by fyn: implications for Alzheimer's disease","volume":"24","author":"Lee","year":"2004","journal-title":"J. Neurosci."},{"key":"10.1016\/j.brainres.2023.148423_b0790","doi-asserted-by":"crossref","first-page":"970","DOI":"10.1001\/archgenpsychiatry.2011.86","article-title":"Temporal relationship between depression and dementia: findings from a large community-based 15-year follow-up study","volume":"68","author":"Li","year":"2011","journal-title":"Arch. Gen. Psychiatry"},{"key":"10.1016\/j.brainres.2023.148423_b0795","doi-asserted-by":"crossref","first-page":"1035","DOI":"10.1007\/s10571-010-9534-8","article-title":"cDNA microarray analysis of gene expression in the cerebral cortex and hippocampus of BALB\/c mice subjected to chronic mild stress","volume":"30","author":"Liu","year":"2010","journal-title":"Cell. Mol. Neurobiol."},{"key":"10.1016\/j.brainres.2023.148423_b0800","doi-asserted-by":"crossref","first-page":"1686","DOI":"10.1038\/s41596-018-0011-z","article-title":"Sucrose preference test for measurement of stress-induced anhedonia in mice","volume":"13","author":"Liu","year":"2018","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.brainres.2023.148423_b0805","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1080\/13554790490896893","article-title":"Non-cognitive symptoms in mild cognitive impairment subjects","volume":"11","author":"Lopez","year":"2005","journal-title":"Neurocase"},{"key":"10.1016\/j.brainres.2023.148423_b0810","doi-asserted-by":"crossref","first-page":"2115","DOI":"10.1212\/WNL.0b013e3181aa52d3","article-title":"Alzheimer's disease cooperative study donepezil delays progression to AD in MCI subjects with depressive symptoms","volume":"72","author":"Lu","year":"2009","journal-title":"Neurology"},{"key":"10.1016\/j.brainres.2023.148423_b0820","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1176\/jnp.9.4.556","article-title":"Major and minor depression in Alzheimer's disease: prevalence and impact","volume":"9","author":"Lyketsos","year":"1997","journal-title":"J. Neuropsychiatr. Clin. Neurosci."},{"key":"10.1016\/j.brainres.2023.148423_b0825","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1001\/archpsyc.60.7.737","article-title":"Treating depression in Alzheimer disease: efficacy and safety of sertraline therapy, and the benefits of depression reduction: the DIADS","volume":"60","author":"Lyketsos","year":"2003","journal-title":"Arch. Gen. Psychiatry"},{"issue":"17","key":"10.1016\/j.brainres.2023.148423_b0830","doi-asserted-by":"crossref","first-page":"27676","DOI":"10.18632\/oncotarget.15398","article-title":"Fluoxetine attenuates the impairment of spatial learning ability and prevents neuron loss in middle-aged APPswe\/PSEN1dE9 double transgenic Alzheimer\u2019s disease mice","volume":"8","author":"Ma","year":"2017","journal-title":"Oncotarget"},{"key":"10.1016\/j.brainres.2023.148423_b0835","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1016\/j.pnpbp.2010.05.004","article-title":"A review on the oxidative and nitrosative stress (O&NS) pathways in major depression and their possible contribution to the (neuro)degenerative processes in that illness","volume":"35","author":"Maes","year":"2011","journal-title":"Prog. Neuropsychopharmacol. Biol. Psychiatry"},{"key":"10.1016\/j.brainres.2023.148423_b0840","doi-asserted-by":"crossref","first-page":"3693","DOI":"10.1074\/jbc.M110.135244","article-title":"Amyloid-beta protein oligomer at low nanomolar concentrations activates microglia and induces microglial neurotoxicity","volume":"286","author":"Maezawa","year":"2011","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.brainres.2023.148423_b0845","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1097\/00019442-200002000-00009","article-title":"A controlled clinical trial of sertraline in the treatment of depression in nursing home patients with late-stage Alzheimer's disease","volume":"8","author":"Magai","year":"2000","journal-title":"Am. J. Geriatr. Psychiatry"},{"key":"10.1016\/j.brainres.2023.148423_b0850","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1038\/ncb1007","article-title":"Crosstalk between Rap1 and Rac regulates secretion of sAPP\u03b1","volume":"5","author":"Maillet","year":"2003","journal-title":"Nat. Cell Biol."},{"issue":"4","key":"10.1016\/j.brainres.2023.148423_b0855","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1016\/0092-8674(94)90517-7","article-title":"Synaptic plasticity in the hippocampus: LTP and LTD","volume":"78","author":"Malenka","year":"1994","journal-title":"Cell"},{"issue":"1","key":"10.1016\/j.brainres.2023.148423_b0860","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1016\/j.neuron.2004.09.012","article-title":"LTP and LTD: An embarrassment of riches","volume":"44","author":"Malenka","year":"2004","journal-title":"Neuron"},{"issue":"2","key":"10.1016\/j.brainres.2023.148423_b0865","doi-asserted-by":"crossref","first-page":"156","DOI":"10.2174\/187152710791012071","article-title":"Microglia and Inflammation in Alzheimer\u2019s Disease","volume":"9","author":"Mandrekar","year":"2010","journal-title":"CNS Neurol. Disord. Drug Targets"},{"key":"10.1016\/j.brainres.2023.148423_b0870","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1038\/bjp.2008.281","article-title":"Effects of 5-HT6 receptor antagonism and cholinesterase inhibition in models of cognitive impairment in the rat","volume":"155","author":"Marcos","year":"2008","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.brainres.2023.148423_b0875","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1146\/annurev.neuro.23.1.649","article-title":"Synaptic plasticity and memory: An evaluation of the hypothesis","volume":"23","author":"Martin","year":"2000","journal-title":"Annu. Rev. Neurosci."},{"key":"10.1016\/j.brainres.2023.148423_b0880","doi-asserted-by":"crossref","first-page":"1078","DOI":"10.1007\/s12035-015-9680-6","article-title":"SK3 channel overexpression in mice causes hippocampal shrinkage associated with cognitive impairments","volume":"54","author":"Martin","year":"2017","journal-title":"Mol. Neurobiol."},{"issue":"7000","key":"10.1016\/j.brainres.2023.148423_b0885","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1038\/nature02621","article-title":"Pathways towards and away from Alzheimer\u2019s disease","volume":"430","author":"Mattson","year":"2004","journal-title":"Nature"},{"key":"10.1016\/j.brainres.2023.148423_b0890","doi-asserted-by":"crossref","first-page":"26326","DOI":"10.1074\/jbc.M611687200","article-title":"Partial reduction of BACE1 has dramatic effects on Alzheimer plaque and synaptic pathology in APP Transgenic Mice","volume":"282","author":"McConlogue","year":"2007","journal-title":"J. Biol. Chem."},{"issue":"1","key":"10.1016\/j.brainres.2023.148423_b0895","first-page":"41","article-title":"Selective serotonin reuptake inhibitors and Alzheimer\u2019s disease","volume":"15","author":"Mdawar","year":"2019","journal-title":"Neural Regen. Res."},{"key":"10.1016\/j.brainres.2023.148423_b0900","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1016\/S0893-133X(97)00194-2","article-title":"Serotonin in aging, late-life depression, and Alzheimer's disease: the emerging role of functional imaging","volume":"18","author":"Meltzer","year":"1998","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.brainres.2023.148423_b0905","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/j.neuroscience.2017.12.046","article-title":"Celecoxib prevents cognitive impairment and neuroinflammation in soluble amyloid \u03b2-treated rats","volume":"372","author":"Mhillaj","year":"2018","journal-title":"Neuroscience"},{"key":"10.1016\/j.brainres.2023.148423_b0910","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1038\/nri.2015.5","article-title":"The role of inflammation in depression: from evolutionary imperative to modern treatment target","volume":"16","author":"Miller","year":"2016","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.brainres.2023.148423_b0915","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1111\/j.1440-1789.2010.01193.x","article-title":"An immunohistochemical study of the serotonin 1A receptor in the hippocampus of subjects with Alzheimer's disease","volume":"31","author":"Mizukami","year":"2011","journal-title":"Neuropathology"},{"key":"10.1016\/j.brainres.2023.148423_b0920","doi-asserted-by":"crossref","first-page":"1290","DOI":"10.1001\/archneur.61.8.1290","article-title":"Depression in patients with mild cognitive impairment increases the risk of developing dementia of Alzheimer type: a prospective cohort study","volume":"61","author":"Modrego","year":"2004","journal-title":"Arch. Neurol."},{"key":"10.1016\/j.brainres.2023.148423_b0925","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1007\/s00213-011-2518-7","article-title":"The effects of PRX-07034, a novel 5-HT6 antagonist, on cognitive flexibility and working memory in rats","volume":"220","author":"Mohler","year":"2012","journal-title":"Psychopharmacology"},{"key":"10.1016\/j.brainres.2023.148423_b0930","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.ejphar.2012.04.041","article-title":"Involvement of different types of potassium channels in the antidepressant-like effect of ascorbic acid in the mouse tail suspension test","volume":"687","author":"Moretti","year":"2012","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.brainres.2023.148423_b0935","doi-asserted-by":"crossref","first-page":"428","DOI":"10.3389\/fnins.2015.00428","article-title":"Soluble beta amyloid evokes alteration in brain norepinephrine levels: Role of nitric oxide and interleukin-1","volume":"9","author":"Morgese","year":"2015","journal-title":"Front. Neurosci."},{"issue":"3","key":"10.1016\/j.brainres.2023.148423_b0940","doi-asserted-by":"crossref","first-page":"2079","DOI":"10.1007\/s12035-016-9809-2","article-title":"Lifelong nutritional omega-3 deficiency evokes depressive-like state through soluble beta amyloid","volume":"54","author":"Morgese","year":"2017","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.brainres.2023.148423_b0945","doi-asserted-by":"crossref","first-page":"526","DOI":"10.1016\/j.phrs.2017.11.034","article-title":"N-3 PUFA diet enrichment prevents amyloid beta-induced depressive-like phenotype","volume":"129","author":"Morgese","year":"2018","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.brainres.2023.148423_b0950","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1124\/jpet.102.034249","article-title":"SL65.0155, a novel 5-hydroxytryptamine(4) receptor partial agonist with potent cognition-enhancing properties","volume":"302","author":"Moser","year":"2002","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.brainres.2023.148423_b0955","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1002\/hipo.20622","article-title":"KCa2 channels transiently downregulated during spatial learning and memory in rats","volume":"20","author":"Mpari","year":"2010","journal-title":"Hippocampus"},{"key":"10.1016\/j.brainres.2023.148423_b0960","doi-asserted-by":"crossref","first-page":"2312","DOI":"10.1111\/j.1471-4159.2008.05557.x","article-title":"Identification and characterization of a novel, shorter isoform of the small conductance Ca2+ -activated K+ channel SK2","volume":"106","author":"Murthy","year":"2008","journal-title":"J. Neurochem."},{"key":"10.1016\/j.brainres.2023.148423_b0965","doi-asserted-by":"crossref","first-page":"642","DOI":"10.1038\/nn1449","article-title":"SKCs and NMDA receptors form a Ca2+-mediated feedback loop in dendritic spines","volume":"8","author":"Ngo-Anh","year":"2005","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.brainres.2023.148423_b0970","doi-asserted-by":"crossref","first-page":"1203","DOI":"10.1111\/bph.12240","article-title":"Calcium channel blockers and dementia","volume":"169","author":"Nimmrich","year":"2013","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.brainres.2023.148423_b0975","doi-asserted-by":"crossref","first-page":"3171","DOI":"10.1523\/JNEUROSCI.18-09-03171.1998","article-title":"Reversal of age-related alterations in synaptic plasticity by blockade of L-type Ca2+ channels","volume":"18","author":"Norris","year":"1998","journal-title":"J. Neurosci."},{"key":"10.1016\/j.brainres.2023.148423_b0980","doi-asserted-by":"crossref","first-page":"1043","DOI":"10.5692\/clinicalneurol.53.1043","article-title":"Oxidative stress hypothesis for Alzheimer's disease and its potential therapeutic implications","volume":"53","author":"Nunomura","year":"2013","journal-title":"Rinsho Shinkeigaku"},{"key":"10.1016\/j.brainres.2023.148423_b0985","article-title":"Can animal models inform on the relationship between depression and alzheimer disease?","volume":"706743718772514","author":"Nyarko","year":"2018","journal-title":"Can. J. Psychiatry"},{"key":"10.1016\/j.brainres.2023.148423_b0990","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1016\/0006-8993(90)91296-S","article-title":"Functional significance of the apamin-sensitive conductance in rat locus coeruleus neurons","volume":"530","author":"Osmanovic","year":"1990","journal-title":"Brain Res."},{"key":"10.1016\/j.brainres.2023.148423_b0995","doi-asserted-by":"crossref","first-page":"530","DOI":"10.1001\/archpsyc.63.5.530","article-title":"Depression and risk for Alzheimer disease: systematic review, meta-analysis, and metaregression analysis","volume":"63","author":"Ownby","year":"2006","journal-title":"Arch. Gen. Psychiatry"},{"key":"10.1016\/j.brainres.2023.148423_b1000","first-page":"401","article-title":"The oxidative stress hypothesis in Alzheimer's disease","volume":"25","author":"Padurariu","year":"2013","journal-title":"Psychiatr. Danub."},{"key":"10.1016\/j.brainres.2023.148423_b1005","doi-asserted-by":"crossref","first-page":"175","DOI":"10.3233\/JAD-2010-1352","article-title":"Neuropsychiatric predictors of progression from amnestic-mild cognitive impairment to Alzheimer's disease: the role of depression and apathy","volume":"20","author":"Palmer","year":"2010","journal-title":"J. Alzheimers Dis."},{"key":"10.1016\/j.brainres.2023.148423_b1010","doi-asserted-by":"crossref","first-page":"726","DOI":"10.1002\/gps.1967","article-title":"Impact of depressive symptoms on the rate of progression to dementia in patients affected by mild cognitive impairment. The Italian Longitudinal Study on Aging","volume":"23","author":"Panza","year":"2008","journal-title":"Int. J. Geriatr. Psychiatry"},{"key":"10.1016\/j.brainres.2023.148423_b1015","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1006\/nbdi.1998.0207","article-title":"Synaptic transmission and hippocampal long-term potentiation in transgenic mice expressing FAD-linked presenilin 1","volume":"6","author":"Parent","year":"1999","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.brainres.2023.148423_b1020","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1017\/S1461145711000782","article-title":"Modulation of neuroplasticity pathways and antidepressant-like behavioural responses following the short-term (3 and 7 days) administration of the 5-HT4 receptor agonist RS67333","volume":"15","author":"Pascual-Brazo","year":"2012","journal-title":"Int. J. Neuropsychopharm."},{"key":"10.1016\/j.brainres.2023.148423_b1025","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1002\/med.20245","article-title":"5-HT radioligands for human brain imaging with PET and SPECT","volume":"33","author":"Paterson","year":"2013","journal-title":"Med. Res. Rev."},{"key":"10.1016\/j.brainres.2023.148423_b1030","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1007\/s00401-002-0657-y","article-title":"Role of protein kinase B in Alzheimer's neurofibrillary pathology","volume":"105","author":"Pei","year":"2003","journal-title":"Acta Neuropathol."},{"key":"10.1016\/j.brainres.2023.148423_b1035","doi-asserted-by":"crossref","first-page":"200","DOI":"10.3389\/fphar.2015.00200","article-title":"5-HT6 receptor agonism facilitates emotional learning","volume":"6","author":"Pereira","year":"2015","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.brainres.2023.148423_b1040","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1017\/S104161020100761X","article-title":"A double-blind, placebo-controlled study of fluoxetine in depressed patients with Alzheimer's disease","volume":"13","author":"Petracca","year":"2001","journal-title":"Int. Psychogeriatr."},{"key":"10.1016\/j.brainres.2023.148423_b1045","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1124\/mol.61.1.85","article-title":"Differences in signal transduction of two 5-HT4 receptor splice variants: compound specificity and dual coupling with Galphas- and Galphai\/o-proteins","volume":"61","author":"Pindon","year":"2002","journal-title":"Mol. Pharmacol."},{"key":"10.1016\/j.brainres.2023.148423_b1050","doi-asserted-by":"crossref","first-page":"1673","DOI":"10.1016\/j.neurobiolaging.2005.09.038","article-title":"Amyloid beta peptide as a physiological modulator of neuronal \u2019A\u2019-type K+ current","volume":"27","author":"Plant","year":"2006","journal-title":"Neurobiol. Aging"},{"issue":"49","key":"10.1016\/j.brainres.2023.148423_b1055","doi-asserted-by":"crossref","first-page":"11231","DOI":"10.1523\/JNEUROSCI.1724-05.2005","article-title":"Contribution of 5-HT2 receptor subtypes to sleep-wakefulness and respiratory control, and functional adaptations in knock-out mice lacking 5-HT2A receptors","volume":"25","author":"Popa","year":"2005","journal-title":"J. Neurosci."},{"key":"10.1016\/j.brainres.2023.148423_b1060","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1186\/alzrt169","article-title":"5-HT6 receptors and Alzheimer's disease","volume":"5","author":"Ramirez","year":"2013","journal-title":"Alzheimers Res. Ther."},{"key":"10.1016\/j.brainres.2023.148423_b1065","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1007\/s40265-014-0217-5","article-title":"Serotonergic therapies for cognitive symptoms in Alzheimer's disease: rationale and current status","volume":"74","author":"Ramirez","year":"2014","journal-title":"Drugs"},{"key":"10.1016\/j.brainres.2023.148423_b1070","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1001\/archpsyc.63.2.161","article-title":"Increased hippocampal plaques and tangles in patients with Alzheimer disease with a lifetime history of major depression","volume":"63","author":"Rapp","year":"2006","journal-title":"Arch. Gen. Psychiatry"},{"key":"10.1016\/j.brainres.2023.148423_b1075","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1097\/JGP.0b013e31816029ec","article-title":"Increased neurofibrillary tangles in patients with Alzheimer disease with comorbid depression","volume":"16","author":"Rapp","year":"2008","journal-title":"Am. J. Geriatr. Psychiatry"},{"key":"10.1016\/j.brainres.2023.148423_b1080","doi-asserted-by":"crossref","first-page":"524","DOI":"10.1111\/j.1472-8206.1996.tb00610.x","article-title":"The effect of the potassium channel activator, cromakalim, on antidepressant drugs in the forced swimming test in mice","volume":"10","author":"Redrobe","year":"1996","journal-title":"Fundam. Clin. Pharmacol."},{"key":"10.1016\/j.brainres.2023.148423_b1085","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1007\/s004060070023","article-title":"Comorbidity of mild cognitive disorder and depression\u2013a neuropsychological analysis","volume":"250","author":"Reischies","year":"2000","journal-title":"Eur. Arch. Psychiatry Clin. Neurosci."},{"issue":"5","key":"10.1016\/j.brainres.2023.148423_b1090","doi-asserted-by":"crossref","first-page":"993","DOI":"10.1111\/j.1476-5381.1995.tb13303.x","article-title":"5-Hydroxytryptamine (5-HT)4 receptors in post mortem human brain tissue: Distribution, pharmacology and effects of neurodegenerative diseases","volume":"114","author":"Reynolds","year":"1995","journal-title":"Br. J. Pharmacol."},{"issue":"2\u20133","key":"10.1016\/j.brainres.2023.148423_b1095","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1159\/000338239","article-title":"Symptoms of apathy are associated with progression from mild cognitive impairment to Alzheimer\u2019s disease in non-depressed subjects","volume":"33","author":"Richard","year":"2012","journal-title":"Dement. Geriatr. Cogn. Disord."},{"key":"10.1016\/j.brainres.2023.148423_b1100","doi-asserted-by":"crossref","first-page":"814","DOI":"10.1038\/cdd.2015.146","article-title":"Activation of SK2 channels preserves ER Ca2+ homeostasis and protects against ER stress-induced cell death","volume":"23","author":"Richter","year":"2016","journal-title":"Cell Death Differ."},{"key":"10.1016\/j.brainres.2023.148423_b1105","doi-asserted-by":"crossref","first-page":"44881","DOI":"10.1074\/jbc.M109008200","article-title":"The human serotonin 5-HT4 receptor regulates secretion of non-amyloidogenic precursor protein","volume":"276","author":"Robert","year":"2001","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.brainres.2023.148423_b1110","doi-asserted-by":"crossref","first-page":"1198","DOI":"10.1021\/acs.chemrestox.0c00411","article-title":"Antidepressant actions of ketamine: potential role of L-type calcium channels","volume":"34","author":"Robinson","year":"2021","journal-title":"Chem. Res. Toxicol."},{"key":"10.1016\/j.brainres.2023.148423_b1115","article-title":"Depressive-like behavior is paired to monoaminergic alteration in a murine model of Alzheimer's disease","volume":"18","author":"Romano","year":"2014","journal-title":"Int. J. Neuropsychopharmacol."},{"key":"10.1016\/j.brainres.2023.148423_b1120","doi-asserted-by":"crossref","unstructured":"Rosenberg, P. B., Drye, L. T., Martin, B. K., Frangakis, C., Mintzer, J. E., Weintraub, D., Porsteinsson, A. P., Schneider, L. S., Rabins, P. V., Munro, C. A., Meinert, C. L., Lyketsos, C. G. & Group, D.-R. 2010. Sertraline for the treatment of depression in Alzheimer disease. Am J Geriatr Psychiatry, 18, 136-45.","DOI":"10.1097\/JGP.0b013e3181c796eb"},{"key":"10.1016\/j.brainres.2023.148423_b1125","doi-asserted-by":"crossref","first-page":"1108","DOI":"10.1111\/j.1460-9568.2008.06430.x","article-title":"SKCblockade promotes burst firing in dorsal raphe serotonergic neurons","volume":"28","author":"Rouchet","year":"2008","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.brainres.2023.148423_b1130","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1159\/000111133","article-title":"Neuropsychiatric symptoms in amnestic and nonamnestic mild cognitive impairment","volume":"25","author":"Rozzini","year":"2008","journal-title":"Dement. Geriatr. Cogn. Disord."},{"key":"10.1016\/j.brainres.2023.148423_b1135","doi-asserted-by":"crossref","unstructured":"R\u00fcb B, U., Del Tredici, K., Schultz, C., Thal, D. R., Braak, E. & Braak, H. 2000. The evolution of Alzheimer's disease-related cytoskeletal pathology in the human raphe nuclei. Neuropathol Appl Neurobiol, 26, 553-67.","DOI":"10.1046\/j.0305-1846.2000.00291.x"},{"key":"10.1016\/j.brainres.2023.148423_b1140","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1212\/WNL.0b013e3181e62138","article-title":"Depressive symptoms and risk of dementia: the Framingham Heart Study","volume":"75","author":"Saczynski","year":"2010","journal-title":"Neurology"},{"key":"10.1016\/j.brainres.2023.148423_b1145","doi-asserted-by":"crossref","first-page":"4708","DOI":"10.1523\/JNEUROSCI.4917-08.2009","article-title":"Expression of human amyloid precursor protein in rat cortical neurons inhibits calcium oscillations","volume":"29","author":"Santos","year":"2009","journal-title":"J. Neurosci."},{"key":"10.1016\/j.brainres.2023.148423_b1150","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.21416","article-title":"Chronic social isolation reduces 5-HT neuronal activity via upregulated SK3 calcium-activated potassium channels","volume":"5","author":"Sargin","year":"2016","journal-title":"Elife"},{"key":"10.1016\/j.brainres.2023.148423_b1155","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1097\/JNN.0b013e3182527690","article-title":"The impact of inflammation on cognitive function in older adults: implications for healthcare practice and research","volume":"44","author":"Sartori","year":"2012","journal-title":"J. Neurosci. Nurs."},{"key":"10.1016\/j.brainres.2023.148423_b1160","doi-asserted-by":"crossref","first-page":"6863","DOI":"10.1523\/JNEUROSCI.22-16-06863.2002","article-title":"Glycogen synthase kinase-3 is activated in neuronal cells by G\u03b112 and G\u03b113 by Rho-independent and Rho-dependent mechanisms","volume":"22","author":"Sayas","year":"2002","journal-title":"J. Neurosci."},{"key":"10.1016\/j.brainres.2023.148423_b1165","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1016\/S0022-3565(24)36805-3","article-title":"The potassium channel blockers 4-aminopyridine and tetraethylammonium increase the spontaneous basal release of [3H]5-hydroxytryptamine in rat hippocampal slices","volume":"282","author":"Schechter","year":"1997","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.brainres.2023.148423_b1170","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1016\/j.pnpbp.2017.05.004","article-title":"Antidepressant drugs for beta amyloid-induced depression: A new standpoint?","volume":"78","author":"Schiavone","year":"2017","journal-title":"Prog. Neuropsychopharmacol. Biol. Psychiatry"},{"key":"10.1016\/j.brainres.2023.148423_b1175","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1186\/1742-2094-7-4","article-title":"The Ca2+ activated SK3 channel is expressed in microglia in the rat striatum and contributes to microglia-mediated neurotoxicity in vitro","volume":"7","author":"Schlichter","year":"2010","journal-title":"J. Neuroinflammation"},{"key":"10.1016\/j.brainres.2023.148423_b1180","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1152\/jn.1988.59.2.424","article-title":"Multiple potassium conductances and their functions in neurons from cat sensorimotor cortex in vitro","volume":"59","author":"Schwindt","year":"1988","journal-title":"J. Neurophysiol."},{"issue":"1","key":"10.1016\/j.brainres.2023.148423_b1185","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1111\/j.1749-6632.2000.tb05554.x","article-title":"Toward a comprehensive theory for alzheimer\u2019s disease. hypothesis: alzheimer\u2019s disease is caused by the cerebral accumulation and cytotoxicity of amyloid \u03b2-protein","volume":"924","author":"Selkoe","year":"2000","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"10.1016\/j.brainres.2023.148423_b1190","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1007\/s40266-012-0012-5","article-title":"Effect of selective serotonin reuptake inhibitors in Alzheimer's disease with comorbid depression: a meta-analysis of depression and cognitive outcomes","volume":"29","author":"Sepehry","year":"2012","journal-title":"Drugs Aging"},{"key":"10.1016\/j.brainres.2023.148423_b1195","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1016\/0006-8993(93)90675-D","article-title":"Apamin increases NMDA-induced burst-firing of rat mesencephalic dopamine neurons","volume":"630","author":"Seutin","year":"1993","journal-title":"Brain Res."},{"key":"10.1016\/j.brainres.2023.148423_b1200","doi-asserted-by":"crossref","unstructured":"Shalat, S. L., Seltzer, B., Pidcock, C. & Baker, E. L. 1987. Risk factors for Alzheimer's disease A case\u2010control study. Neurology, 37, 1630-1630.","DOI":"10.1212\/WNL.37.10.1630"},{"key":"10.1016\/j.brainres.2023.148423_b1205","doi-asserted-by":"crossref","first-page":"82","DOI":"10.5455\/2319-2003.ijbcp20150215","article-title":"Effects of calcium channel blocker, nifedipine, on antidepressant activity of fluvoxamine, venlafaxine and tianeptine in mice","volume":"4","author":"Sharma","year":"2015","journal-title":"Int. J. Basic & Clinical Pharmacology"},{"key":"10.1016\/j.brainres.2023.148423_b1210","doi-asserted-by":"crossref","unstructured":"Sheline, Y.I., West, T., Yarasheski, K., Swarm, R., Jasielec, M.S., Fisher, J.R., Ficker, W.D., Yan, P., Xiong, C., Frederiksen, C., Grzelak, M.V., Chott, R., Bateman, R.J., Morris, J.C., Mintun, M.A., Lee, J.-M., Cirrito, J.R. 2014. An Antidepressant Decreases CSF A\u03b2 Production in Healthy Individuals and in Transgenic AD Mice. Sci. Transl. Med. 6. 236re4-236re4.","DOI":"10.1126\/scitranslmed.3008169"},{"key":"10.1016\/j.brainres.2023.148423_b1215","article-title":"SKCModulates synaptic plasticity by tuning camkii\u03b1\/\u03b2 dynamics. frontiers in synaptic","volume":"11","author":"Shrestha","year":"2019","journal-title":"Neuroscience"},{"key":"10.1016\/j.brainres.2023.148423_b1220","doi-asserted-by":"crossref","unstructured":"Simic, G., Babic Leko, M., Wray, S., Harrington, C. R., Delalle, I., Jovanov-Milosevic, N., Bazadona, D., Buee, L., De Silva, R., Di Giovanni, G., Wischik, C. M. & Hof, P. R. 2017. Monoaminergic neuropathology in Alzheimer's disease. Prog Neurobiol, 151, 101-138.","DOI":"10.1016\/j.pneurobio.2016.04.001"},{"key":"10.1016\/j.brainres.2023.148423_b1225","doi-asserted-by":"crossref","first-page":"532","DOI":"10.1111\/j.1365-2990.2009.01038.x","article-title":"Does Alzheimer's disease begin in the brainstem?","volume":"35","author":"Simic","year":"2009","journal-title":"Neuropathol. Appl. Neurobiol."},{"key":"10.1016\/j.brainres.2023.148423_b1230","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1016\/j.nbd.2008.11.005","article-title":"Overexpression of wild-type human APP in mice causes cognitive deficits and pathological features unrelated to A\u03b2 levels","volume":"33","author":"Sim\u00f3n","year":"2009","journal-title":"Neurobiol. Dis."},{"issue":"7","key":"10.1016\/j.brainres.2023.148423_b1235","doi-asserted-by":"crossref","first-page":"712","DOI":"10.1001\/jamapsychiatry.2017.0660","article-title":"Trajectories of depressive symptoms before diagnosis of dementia: a 28-year follow-up study","volume":"74","author":"Singh-Manoux","year":"2017","journal-title":"JAMA Psychiat."},{"key":"10.1016\/j.brainres.2023.148423_b1240","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1016\/j.physbeh.2017.07.023","article-title":"Silibinin ameliorates anxiety\/depression-like behaviors in amyloid beta-treated rats by upregulating BDNF\/TrkB pathway and attenuating autophagy in hippocampus","volume":"179","author":"Song","year":"2017","journal-title":"Physiol. Behav."},{"key":"10.1016\/j.brainres.2023.148423_b1245","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1097\/00001648-199507000-00006","article-title":"History of depression as a risk factor for Alzheimer's disease","volume":"6","author":"Speck","year":"1995","journal-title":"Epidemiology"},{"key":"10.1016\/j.brainres.2023.148423_b1250","doi-asserted-by":"crossref","first-page":"10163","DOI":"10.1523\/JNEUROSCI.22-23-10163.2002","article-title":"Small conductance Ca2+-activated K+ channels modulate synaptic plasticity and memory encoding","volume":"22","author":"Stackman","year":"2002","journal-title":"J. Neurosci."},{"key":"10.1016\/j.brainres.2023.148423_b1255","doi-asserted-by":"crossref","first-page":"314","DOI":"10.3389\/fncel.2014.00314","article-title":"Rho family GTPases: key players in neuronal development, neuronal survival, and neurodegeneration","volume":"8","author":"Stankiewicz","year":"2014","journal-title":"Front. Cell. Neurosci."},{"key":"10.1016\/j.brainres.2023.148423_b1260","doi-asserted-by":"crossref","first-page":"2086","DOI":"10.1176\/appi.ajp.162.11.2086","article-title":"The construct of minor and major depression in Alzheimer's disease","volume":"162","author":"Starkstein","year":"2005","journal-title":"Am. J. Psychiatry"},{"issue":"1","key":"10.1016\/j.brainres.2023.148423_b1265","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1016\/S0022-3565(24)38897-4","article-title":"Serotonergic modulation of rat pineal gland activity. in vivo evidence for a 5-hydroxytryptamine2C receptor involvement","volume":"295","author":"Steardo","year":"2000","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.brainres.2023.148423_b1270","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1177\/0891988704269819","article-title":"Methodology and preliminary results from the neurocognitive outcomes of depression in the elderly study","volume":"17","author":"Steffens","year":"2004","journal-title":"J. Geriatr. Psychiatry Neurol."},{"key":"10.1016\/j.brainres.2023.148423_b1275","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1006\/mcne.2000.0842","article-title":"Differential distribution of three Ca(2+)-activated K(+) channel subunits, SK1, SK2, and SK3, in the adult rat central nervous system","volume":"15","author":"Stocker","year":"2000","journal-title":"Mol. Cell. Neurosci."},{"issue":"1","key":"10.1016\/j.brainres.2023.148423_b1280","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1515\/tnsci-2016-0007","article-title":"The serotonergic system and cognitive function","volume":"7","author":"\u0160trac","year":"2016","journal-title":"Transl. Neurosci."},{"key":"10.1016\/j.brainres.2023.148423_b1285","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1177\/1073858404270899","article-title":"Calcium dysregulation, IP3 signaling, and Alzheimer's disease","volume":"11","author":"Stutzmann","year":"2005","journal-title":"Neuroscientist"},{"issue":"1","key":"10.1016\/j.brainres.2023.148423_b1290","doi-asserted-by":"crossref","first-page":"349","DOI":"10.3233\/JAD-160046","article-title":"Pharmacological modulations of the serotonergic system in a cell-model of familial alzheimer\u2019s disease","volume":"53","author":"Tajeddinn","year":"2016","journal-title":"J. Alzheimer\u2019s Disease: JAD"},{"key":"10.1016\/j.brainres.2023.148423_b1295","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1159\/000107100","article-title":"Neuropsychiatric symptoms are associated with progression from mild cognitive impairment to Alzheimer\u2019s disease","volume":"24","author":"Teng","year":"2007","journal-title":"Dement. Geriatr. Cogn. Disord."},{"key":"10.1016\/j.brainres.2023.148423_b1300","doi-asserted-by":"crossref","first-page":"1779","DOI":"10.1016\/j.neurobiolaging.2013.01.020","article-title":"Chronic 5-HT4 receptor activation decreases A\u03b2 production and deposition in hAPP\/PS1 mice","volume":"34","author":"Tesseur","year":"2013","journal-title":"Neurobiol. Aging"},{"issue":"3","key":"10.1016\/j.brainres.2023.148423_b1305","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1007\/s10571-014-0138-6","article-title":"Activation of 5-HT2C receptor promotes the expression of neprilysin in U251 human glioma cells","volume":"35","author":"Tian","year":"2015","journal-title":"Cell. Mol. Neurobiol."},{"issue":"3","key":"10.1016\/j.brainres.2023.148423_b1310","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1017\/S104161029700447X","article-title":"Risk factors for clinically diagnosed Alzheimer\u2019s disease: A case-control study of a Greek population","volume":"9","author":"Tsolaki","year":"1997","journal-title":"Int. Psychogeriatr."},{"key":"10.1016\/j.brainres.2023.148423_b1315","doi-asserted-by":"crossref","first-page":"2785","DOI":"10.1523\/JNEUROSCI.17-08-02785.1997","article-title":"5-HT2A receptor-mediated regulation of brain-derived neurotrophic factor mRNA in the hippocampus and the neocortex","volume":"17","author":"Vaidya","year":"1997","journal-title":"J. Neurosci."},{"issue":"2","key":"10.1016\/j.brainres.2023.148423_b1320","first-page":"151","article-title":"Late-life depression as a possible predictor of dementia: cross-sectional and short-term follow-up results","volume":"7","author":"van Reekum","year":"1999","journal-title":"Am. J. Geriatr. Psychiatry"},{"key":"10.1016\/j.brainres.2023.148423_b1325","doi-asserted-by":"crossref","first-page":"10816","DOI":"10.3390\/ijms231810816","article-title":"Investigation of anxiety- and depressive-like symptoms in 4- and 8-month-old male triple transgenic mouse models of alzheimer\u2019s disease","volume":"23","author":"V\u00e1rkonyi","year":"2022","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.brainres.2023.148423_b1330","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1016\/S0197-4580(02)00137-9","article-title":"Imaging of the 5-HT2A system: age-, gender-, and Alzheimer's disease-related findings","volume":"24","author":"Versijpt","year":"2003","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.brainres.2023.148423_b1335","doi-asserted-by":"crossref","first-page":"650","DOI":"10.1016\/j.neuropharm.2009.11.008","article-title":"In vivo pharmacological manipulation of small conductance Ca(2+)-activated K(+) channels influences motor behavior, object memory and fear conditioning","volume":"58","author":"Vick","year":"2010","journal-title":"Neuropharmacology"},{"issue":"5","key":"10.1016\/j.brainres.2023.148423_b1340","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1111\/j.1532-5415.2000.tb04992.x","article-title":"Distinction between preclinical alzheimer\u2019s disease and depression","volume":"48","author":"Visser","year":"2000","journal-title":"J. Am. Geriatr. Soc."},{"issue":"2","key":"10.1016\/j.brainres.2023.148423_b1345","doi-asserted-by":"crossref","first-page":"807","DOI":"10.3233\/JAD-200401","article-title":"Escitalopram alleviates alzheimer\u2019s disease-type tau pathologies in the aged P301L Tau transgenic mice","volume":"77","author":"Wang","year":"2020","journal-title":"J. Alzheimer\u2019s Disease: JAD"},{"key":"10.1016\/j.brainres.2023.148423_b1350","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1142\/S021963521650014X","article-title":"Desipramine improves depression-like behavior and working memory by up-regulating p-CREB in Alzheimer's disease associated mice","volume":"15","author":"Wang","year":"2016","journal-title":"J. Integr. Neurosci."},{"key":"10.1016\/j.brainres.2023.148423_b1355","doi-asserted-by":"crossref","unstructured":"Wei, Z., Junhong, G., Xiaoyuan, N., Jie, W., Zhaojun, W., Meina, W., Wei, Y., Jun, Z., & Jinshun, Q. 2017. Citalopram Ameliorates Impairments in Spatial Memory and Synaptic Plasticity in Female 3xTgAD Mice. BioMed Research International, 2017.","DOI":"10.1155\/2017\/1238687"},{"key":"10.1016\/j.brainres.2023.148423_b1360","doi-asserted-by":"crossref","unstructured":"Weintraub, D., Rosenberg, P. B., Drye, L. T., Martin, B. K., Frangakis, C., Mintzer, J. E., Porsteinsson, A. P., Schneider, L. S., Rabins, P. V., Munro, C. A., Meinert, C. L., Lyketsos, C. G. & Group, D.-R. 2010. Sertraline for the treatment of depression in Alzheimer disease: week-24 outcomes. Am J Geriatr Psychiatry, 18, 332-40.","DOI":"10.1097\/JGP.0b013e3181cc0333"},{"key":"10.1016\/j.brainres.2023.148423_b1365","doi-asserted-by":"crossref","first-page":"3443","DOI":"10.1523\/JNEUROSCI.21-10-03443.2001","article-title":"Differential expression of the small-conductance, calcium-activated potassium channel SK3 is critical for pacemaker control in dopaminergic midbrain neurons","volume":"21","author":"Wolfart","year":"2001","journal-title":"J. Neurosci."},{"key":"10.1016\/j.brainres.2023.148423_b1370","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/j.neurobiolaging.2018.03.011","article-title":"Escitalopram alleviates stress-induced Alzheimer's disease-like tau pathologies and cognitive deficits by reducing hypothalamic-pituitary-adrenal axis reactivity and insulin\/GSK-3beta signal pathway activity","volume":"67","author":"Wu","year":"2018","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.brainres.2023.148423_b1375","doi-asserted-by":"crossref","first-page":"1729","DOI":"10.1002\/jnr.21998","article-title":"NMDA receptor-dependent signaling pathways that underlie amyloid beta-protein disruption of LTP in the hippocampus","volume":"87","author":"Yamin","year":"2009","journal-title":"J. Neurosci. Res."},{"key":"10.1016\/j.brainres.2023.148423_b1380","doi-asserted-by":"crossref","first-page":"920","DOI":"10.1002\/gps.4409","article-title":"High amyloid-beta deposition related to depressive symptoms in older individuals with normal cognition: a pilot study","volume":"31","author":"Yasuno","year":"2016","journal-title":"Int. J. Geriatr. Psychiatry"},{"key":"10.1016\/j.brainres.2023.148423_b1385","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1007\/s11357-010-9152-x","article-title":"Localization of 5-HT1A and 5-HT2A positive cells in the brainstems of control age-matched and Alzheimer individuals","volume":"32","author":"Yeung","year":"2010","journal-title":"Age (Dordr.)"},{"key":"10.1016\/j.brainres.2023.148423_b1390","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1017\/S1461145711000411","article-title":"Increased hippocampal tau phosphorylation and axonal mitochondrial transport in a mouse model of chronic stress","volume":"15","author":"Zhang","year":"2012","journal-title":"Int. J. Neuropsychopharmacol."},{"key":"10.1016\/j.brainres.2023.148423_b1395","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1016\/j.neuropharm.2017.12.021","article-title":"Citalopram restores short-term memory deficit and non-cognitive behaviors in APP\/PS1 mice while halting the advance of Alzheimer's disease-like pathology","volume":"131","author":"Zhang","year":"2018","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.brainres.2023.148423_b1400","doi-asserted-by":"crossref","first-page":"1378","DOI":"10.1002\/cne.24616","article-title":"Fluoxetine delays the cognitive function decline and synaptic changes in a transgenic mouse model of early Alzheimer\u2019s disease","volume":"527","author":"Zhou","year":"2019","journal-title":"J Comp Neurol"},{"issue":"12","key":"10.1016\/j.brainres.2023.148423_b1405","doi-asserted-by":"crossref","first-page":"3018","DOI":"10.1016\/j.celrep.2017.02.077","article-title":"Organization of functional long-range circuits controlling the activity of serotonergic neurons in the dorsal raphe nucleus","volume":"18","author":"Zhou","year":"2017","journal-title":"Cell Rep."},{"key":"10.1016\/j.brainres.2023.148423_b1410","article-title":"Possible antidepressant mechanisms of omega-3 polyunsaturated fatty acids acting on the central nervous system","volume":"13","author":"Zhou","year":"2022","journal-title":"Front. Psych."},{"key":"10.1016\/j.brainres.2023.148423_b1415","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1002\/ana.410240210","article-title":"The neuropathology of aminergic nuclei in Alzheimer's disease","volume":"24","author":"Zweig","year":"1988","journal-title":"Ann. Neurol."}],"container-title":["Brain Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006899323001944?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006899323001944?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,13]],"date-time":"2025-09-13T18:25:18Z","timestamp":1757787918000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006899323001944"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,8]]},"references-count":280,"alternative-id":["S0006899323001944"],"URL":"https:\/\/doi.org\/10.1016\/j.brainres.2023.148423","relation":{},"ISSN":["0006-8993"],"issn-type":[{"value":"0006-8993","type":"print"}],"subject":[],"published":{"date-parts":[[2023,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Putative pathological mechanisms of late-life depression and Alzheimer\u2019s disease","name":"articletitle","label":"Article Title"},{"value":"Brain Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.brainres.2023.148423","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"148423"}}