{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,29]],"date-time":"2026-08-29T02:57:38Z","timestamp":1787972258648,"version":"build-2784847793"},"reference-count":57,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T00:00:00Z","timestamp":1701388800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T00:00:00Z","timestamp":1701388800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T00:00:00Z","timestamp":1701388800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T00:00:00Z","timestamp":1701388800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T00:00:00Z","timestamp":1701388800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T00:00:00Z","timestamp":1701388800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T00:00:00Z","timestamp":1701388800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82360455"],"award-info":[{"award-number":["82360455"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Brain Research"],"published-print":{"date-parts":[[2023,12]]},"DOI":"10.1016\/j.brainres.2023.148619","type":"journal-article","created":{"date-parts":[[2023,10,5]],"date-time":"2023-10-05T11:49:51Z","timestamp":1696506591000},"page":"148619","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":9,"special_numbering":"C","title":["Enriched environment alleviates neurological deficits via downregulation of Cx43 after experimental stroke"],"prefix":"10.1016","volume":"1821","author":[{"given":"Xiuping","family":"Chen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wansong","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4145-7456","authenticated-orcid":false,"given":"Hui","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.brainres.2023.148619_b0005","doi-asserted-by":"crossref","first-page":"156","DOI":"10.3389\/fnsys.2014.00156","article-title":"Environmental enrichment and the sensory brain: the role of enrichment in remediating brain injury","volume":"8","author":"Alwis","year":"2014","journal-title":"Frontiers in Systems Neuroscience"},{"issue":"Suppl 1","key":"10.1016\/j.brainres.2023.148619_b0010","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1186\/s12860-016-0120-x","article-title":"Gap junctions and hemichannels: communicating cell death in neurodevelopment and disease","volume":"18","author":"Belousov","year":"2017","journal-title":"BMC Cell Biology"},{"key":"10.1016\/j.brainres.2023.148619_b0015","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1186\/s13578-017-0170-6","article-title":"Phosphorylation of astrocytic connexin43 by ERK1\/2 impairs blood-brain barrier in acute cerebral ischemia","volume":"7","author":"Chen","year":"2017","journal-title":"Cell & Bioscience"},{"issue":"1","key":"10.1016\/j.brainres.2023.148619_b0020","doi-asserted-by":"crossref","first-page":"3575","DOI":"10.1038\/s41598-017-03909-0","article-title":"A non-ionotropic activity of NMDA receptors contributes to glycine-induced neuroprotection in cerebral ischemia-reperfusion injury","volume":"7","author":"Chen","year":"2017","journal-title":"Scientific Reports"},{"key":"10.1016\/j.brainres.2023.148619_b0025","doi-asserted-by":"crossref","first-page":"372","DOI":"10.3389\/fncel.2018.00372","article-title":"Inhibition of connexin 43 hemichannels alleviates cerebral ischemia\/reperfusion injury via the TLR4 signaling pathway","volume":"12","author":"Chen","year":"2018","journal-title":"Frontiers in Cellular Neuroscience"},{"key":"10.1016\/j.brainres.2023.148619_b0030","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1016\/j.brainresbull.2018.12.009","article-title":"Inhibition of Connexin43 hemichannels with Gap19 protects cerebral ischemia\/reperfusion injury via the JAK2\/STAT3 pathway in mice","volume":"146","author":"Chen","year":"2019","journal-title":"Brain Research Bulletin"},{"issue":"5","key":"10.1016\/j.brainres.2023.148619_b0035","doi-asserted-by":"crossref","first-page":"1308","DOI":"10.1007\/s11064-016-2172-x","article-title":"Effect of physical and social components of enriched environment on astrocytes proliferation in rats after cerebral ischemia\/reperfusion injury","volume":"42","author":"Chen","year":"2017","journal-title":"Neurochemical Research"},{"key":"10.1016\/j.brainres.2023.148619_b0040","doi-asserted-by":"crossref","DOI":"10.1016\/j.physbeh.2022.113710","article-title":"Involvement of hippocampal astrocytic connexin-43 in morphine dependence","volume":"247","author":"Darvishmolla","year":"2022","journal-title":"Physiology & Behavior"},{"issue":"Pt 16","key":"10.1016\/j.brainres.2023.148619_b0045","doi-asserted-by":"crossref","first-page":"3241","DOI":"10.1242\/jcs.115.16.3241","article-title":"Cell coupling and Cx43 expression in embryonic mouse neural progenitor cells","volume":"115","author":"Duval","year":"2002","journal-title":"Journal of Cell Science"},{"key":"10.1016\/j.brainres.2023.148619_b0050","first-page":"437","article-title":"Secondary stroke prevention: challenges and solutions","volume":"11","author":"Esenwa","year":"2015","journal-title":"Vascular Health and Risk Management"},{"issue":"8","key":"10.1016\/j.brainres.2023.148619_b0055","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1080\/01616412.2020.1782079","article-title":"Schisandrin B improves cerebral ischemia and reduces reperfusion injury in rats through TLR4\/NF-kappaB signaling pathway inhibition","volume":"42","author":"Fan","year":"2020","journal-title":"Neurological Research"},{"issue":"1","key":"10.1016\/j.brainres.2023.148619_b0060","doi-asserted-by":"crossref","first-page":"e53888","DOI":"10.1371\/journal.pone.0053888","article-title":"Standardized environmental enrichment supports enhanced brain plasticity in healthy rats and prevents cognitive impairment in epileptic rats","volume":"8","author":"Fares","year":"2013","journal-title":"PLoS One1"},{"key":"10.1016\/j.brainres.2023.148619_b0065","doi-asserted-by":"crossref","first-page":"298","DOI":"10.3389\/fphar.2020.00298","article-title":"Neuroprotective effect of Danhong injection on cerebral ischemia-reperfusion injury in rats by activation of the PI3K-Akt pathway","volume":"11","author":"Feng","year":"2020","journal-title":"Frontiers in Pharmacology"},{"issue":"1","key":"10.1016\/j.brainres.2023.148619_b0070","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1007\/s12035-019-01715-5","article-title":"The \u201cuse it or lose it\u201d dogma in the retina: visual stimulation promotes protection against retinal ischemia","volume":"57","author":"Fleitas","year":"2020","journal-title":"Molecular Neurobiology"},{"issue":"10","key":"10.1016\/j.brainres.2023.148619_b0075","doi-asserted-by":"crossref","first-page":"e3080","DOI":"10.1038\/cddis.2017.465","article-title":"RTN1-C mediates cerebral ischemia\/reperfusion injury via ER stress and mitochondria-associated apoptosis pathways","volume":"8","author":"Gong","year":"2017","journal-title":"Cell Death & Disease"},{"issue":"1","key":"10.1016\/j.brainres.2023.148619_b0080","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1007\/s11357-021-00432-z","article-title":"Effect of environmental enrichment and isolation on behavioral and histological indices following focal ischemia in old rats","volume":"44","author":"Gresita","year":"2022","journal-title":"Geroscience"},{"key":"10.1016\/j.brainres.2023.148619_b0085","first-page":"306","article-title":"The effects of early experience on problem-solving at maturity","volume":"2","author":"Hebb","year":"1947","journal-title":"The American Psychologist"},{"issue":"21","key":"10.1016\/j.brainres.2023.148619_b0090","doi-asserted-by":"crossref","DOI":"10.3390\/ijms21218194","article-title":"Regulation of connexin gap junctions and hemichannels by calcium and calcium binding protein calmodulin","volume":"21","author":"Hu","year":"2020","journal-title":"International Journal of Molecular Sciences"},{"issue":"16","key":"10.1016\/j.brainres.2023.148619_b0095","doi-asserted-by":"crossref","first-page":"1194","DOI":"10.1089\/ars.2018.7636","article-title":"Connexin43 contributes to inflammasome activation and lipopolysaccharide-initiated acute renal injury modulation of intracellular oxidative status","volume":"31","author":"Huang","year":"2019","journal-title":"Antioxidants & Redox Signaling"},{"issue":"4","key":"10.1016\/j.brainres.2023.148619_b0100","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1038\/s41583-019-0120-x","article-title":"Environmental enrichment, new neurons and the neurobiology of individuality","volume":"20","author":"Kempermann","year":"2019","journal-title":"Nat Rev Neurosci"},{"issue":"5","key":"10.1016\/j.brainres.2023.148619_b0105","first-page":"e259","article-title":"Global and regional burden of first-ever ischaemic and haemorrhagic stroke during 1990\u20132010_findings from the Global Burden of Disease Study 2010, Lancet Glob","volume":"1","author":"Krishnamurthi","year":"2013","journal-title":"Health"},{"issue":"12","key":"10.1016\/j.brainres.2023.148619_b0110","doi-asserted-by":"crossref","first-page":"23160","DOI":"10.1002\/jcp.28882","article-title":"miR-382-3p suppressed IL-1\u03b2 induced inflammatory response of chondrocytes via the TLR4\/MyD88\/NF-\u03baB signaling pathway by directly targeting CX43","volume":"234","author":"Lei","year":"2019","journal-title":"Journal of Cellular Physiology"},{"key":"10.1016\/j.brainres.2023.148619_b0115","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.semcdb.2015.12.002","article-title":"The cardiac connexome: non-canonical functions of connexin43 and their role in cardiac arrhythmias","volume":"50","author":"Leo-Macias","year":"2016","journal-title":"Seminars in Cell & Developmental Biology"},{"issue":"6","key":"10.1016\/j.brainres.2023.148619_b0120","doi-asserted-by":"crossref","first-page":"1002","DOI":"10.1039\/c9tx00222g","article-title":"Astilbin attenuates cerebral ischemia\/reperfusion injury by inhibiting the TLR4\/MyD88\/NF-kappaB pathway","volume":"8","author":"Li","year":"2019","journal-title":"Toxicol Res (camb)"},{"key":"10.1016\/j.brainres.2023.148619_b0125","doi-asserted-by":"crossref","DOI":"10.1016\/j.tice.2021.101621","article-title":"Gossypol ameliorates the IL-1\u03b2-induced apoptosis and inflammation in chondrocytes by suppressing the activation of TLR4\/MyD88\/NF-\u03baB pathway via downregulating CX43","volume":"73","author":"Li","year":"2021","journal-title":"Tissue & Cell"},{"key":"10.1016\/j.brainres.2023.148619_b0130","doi-asserted-by":"crossref","first-page":"943","DOI":"10.3389\/fphar.2018.00943","article-title":"Combined use of emodin and ginsenoside Rb1 exerts synergistic neuroprotection in cerebral ischemia\/reperfusion rats","volume":"9","author":"Li","year":"2018","journal-title":"Frontiers in Pharmacology"},{"issue":"9","key":"10.1016\/j.brainres.2023.148619_b0135","doi-asserted-by":"crossref","first-page":"1553","DOI":"10.1002\/glia.22826","article-title":"Inhibition of connexin43 improves functional recovery after ischemic brain injury in neonatal rats","volume":"63","author":"Li","year":"2015","journal-title":"Glia"},{"key":"10.1016\/j.brainres.2023.148619_b0140","doi-asserted-by":"crossref","first-page":"703","DOI":"10.3389\/fneur.2020.00703","article-title":"The multifaceted role of astrocyte connexin 43 in ischemic stroke through forming hemichannels and gap junctions","volume":"11","author":"Liang","year":"2020","journal-title":"Frontiers in Neurology"},{"issue":"1","key":"10.1016\/j.brainres.2023.148619_b0145","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1186\/s12974-018-1388-x","article-title":"Fluoxetine attenuates neuroinflammation in early brain injury after subarachnoid hemorrhage: a possible role for the regulation of TLR4\/MyD88\/NF-kappaB signaling pathway","volume":"15","author":"Liu","year":"2018","journal-title":"Journal of Neuroinflammation"},{"key":"10.1016\/j.brainres.2023.148619_b0150","doi-asserted-by":"crossref","DOI":"10.3389\/fnagi.2021.717644","article-title":"Enriched environment attenuates pyroptosis to improve functional recovery after cerebral ischemia\/reperfusion injury","volume":"13","author":"Liu","year":"2021","journal-title":"Frontiers in Aging Neuroscience"},{"issue":"1","key":"10.1016\/j.brainres.2023.148619_b0155","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1161\/01.STR.20.1.84","article-title":"Reversible middle cerebral artery occlusion without craniectomy in rats","volume":"20","author":"Longa","year":"1989","journal-title":"Stroke"},{"issue":"1","key":"10.1016\/j.brainres.2023.148619_b0160","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1186\/s12890-019-1036-y","article-title":"Inhibition of connexin 43 attenuates oxidative stress and apoptosis in human umbilical vein endothelial cells","volume":"20","author":"Ma","year":"2020","journal-title":"BMC Pulmonary Medicine"},{"issue":"5","key":"10.1016\/j.brainres.2023.148619_b0165","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1007\/s12975-021-00912-6","article-title":"Carbonyl reductase 1 attenuates ischemic brain injury by reducing oxidative stress and neuroinflammation","volume":"12","author":"Mao","year":"2021","journal-title":"Translational Stroke Research"},{"issue":"1","key":"10.1016\/j.brainres.2023.148619_b0170","first-page":"99","article-title":"Remote ischemic post-conditioning protects against myocardial ischemia\/reperfusion injury by inhibiting the Rho-kinase signaling pathway","volume":"19","author":"Min","year":"2020","journal-title":"Experimental and Therapeutic Medicine"},{"issue":"9","key":"10.1016\/j.brainres.2023.148619_b0175","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1038\/nrn1970","article-title":"Enriched environments, experience-dependent plasticity and disorders of the nervous system","volume":"7","author":"Nithianantharajah","year":"2006","journal-title":"Nat Rev Neurosci"},{"issue":"34","key":"10.1016\/j.brainres.2023.148619_b0180","doi-asserted-by":"crossref","first-page":"4246","DOI":"10.2174\/1381612826666200708133912","article-title":"Pathophysiology of ischemic stroke: role of oxidative stress","volume":"26","author":"Orellana-Urz\u00faa","year":"2020","journal-title":"Current Pharmaceutical Design"},{"issue":"1","key":"10.1016\/j.brainres.2023.148619_b0185","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1080\/19336950.2019.1631107","article-title":"The role of oligodendrocyte gap junctions in neuroinflammation","volume":"13","author":"Papaneophytou","year":"2019","journal-title":"Channels (Austin, Tex.)"},{"key":"10.1016\/j.brainres.2023.148619_b0190","doi-asserted-by":"crossref","DOI":"10.1016\/j.expneurol.2020.113518","article-title":"Emerging neuroprotective strategies for the treatment of ischemic stroke: an overview of clinical and preclinical studies","volume":"335","author":"Paul","year":"2021","journal-title":"Experimental Neurology"},{"issue":"1","key":"10.1016\/j.brainres.2023.148619_b0195","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/j.bone.2012.09.030","article-title":"Beyond gap junctions: connexin43 and bone cell signaling","volume":"52","author":"Plotkin","year":"2013","journal-title":"Bone"},{"key":"10.1016\/j.brainres.2023.148619_b0200","doi-asserted-by":"crossref","DOI":"10.1016\/j.neulet.2020.135133","article-title":"Effects of exposure to enriched environment during adolescence on passive avoidance memory, nociception, and prefrontal BDNF level in adult male and female rats","volume":"732","author":"Sadegzadeh","year":"2020","journal-title":"Neuroscience Letters"},{"key":"10.1016\/j.brainres.2023.148619_b0205","doi-asserted-by":"crossref","first-page":"7875396","DOI":"10.1155\/2020\/7875396","article-title":"Mechanisms of acupuncture in the regulation of oxidative stress in treating ischemic stroke","volume":"2020","author":"Su","year":"2020","journal-title":"Oxidative Medicine and Cellular Longevity"},{"key":"10.1016\/j.brainres.2023.148619_b0210","article-title":"Prevalence of stroke in China, 2013\u20132019: a population-based study","volume":"28","author":"Tu","year":"2022","journal-title":"Lancet Reg Health West Pac"},{"key":"10.1016\/j.brainres.2023.148619_b0215","doi-asserted-by":"crossref","first-page":"1060","DOI":"10.3389\/fphys.2017.01060","article-title":"Connexins in the central nervous system: physiological traits and neuroprotective targets","volume":"8","author":"Vicario","year":"2017","journal-title":"Frontiers in Physiology"},{"issue":"1","key":"10.1016\/j.brainres.2023.148619_b0220","doi-asserted-by":"crossref","first-page":"11","DOI":"10.4196\/kjpp.2020.24.1.11","article-title":"Neuroprotective potential of imatinib in global ischemia-reperfusion-induced cerebral injury: possible role of Janus-activated kinase 2\/signal transducer and activator of transcription 3 and connexin 43","volume":"24","author":"Wang","year":"2020","journal-title":"Korean Journal of Physiology & Pharmacology"},{"issue":"5","key":"10.1016\/j.brainres.2023.148619_b0225","first-page":"1345","article-title":"Baicalein promotes neuronal and behavioral recovery after intracerebral hemorrhage via suppressing apoptosis","volume":"42","author":"Wei","year":"2017","journal-title":"Oxidative Stress and Neuroinflammation, Neurochem Res"},{"issue":"4","key":"10.1016\/j.brainres.2023.148619_b0230","doi-asserted-by":"crossref","first-page":"923","DOI":"10.1016\/j.bbrc.2017.05.005","article-title":"LncRNA Gm4419 contributes to OGD\/R injury of cerebral microglial cells via I\u03baB phosphorylation and NF-\u03baB activation","volume":"487","author":"Wen","year":"2017","journal-title":"Biochemical and Biophysical Research Communications"},{"issue":"7","key":"10.1016\/j.brainres.2023.148619_b0235","doi-asserted-by":"crossref","first-page":"593","DOI":"10.3109\/09638288.2014.935876","article-title":"Exploring stroke survivor experience of participation in an enriched environment: a qualitative study","volume":"37","author":"White","year":"2015","journal-title":"Disability and Rehabilitation"},{"key":"10.1016\/j.brainres.2023.148619_b0240","doi-asserted-by":"crossref","first-page":"501","DOI":"10.3389\/fphar.2019.00501","article-title":"Fast green FCF attenuates lipopolysaccharide-induced depressive-like behavior and downregulates TLR4\/Myd88\/NF-kappaB signal pathway in the mouse hippocampus","volume":"10","author":"Yang","year":"2019","journal-title":"Frontiers in Pharmacology"},{"issue":"1","key":"10.1016\/j.brainres.2023.148619_b0245","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.bbrc.2016.10.007","article-title":"MyD88 contributes to neuroinflammatory responses induced by cerebral ischemia\/reperfusion in mice","volume":"480","author":"Ye","year":"2016","journal-title":"Biochemical and Biophysical Research Communications"},{"issue":"1","key":"10.1016\/j.brainres.2023.148619_b0250","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1186\/s12974-020-01978-z","article-title":"Targeting connexin 43 provides anti-inflammatory effects after intracerebral hemorrhage injury by regulating YAP signaling","volume":"17","author":"Yu","year":"2020","journal-title":"Journal of Neuroinflammation"},{"key":"10.1016\/j.brainres.2023.148619_b0255","doi-asserted-by":"crossref","DOI":"10.1016\/j.nbd.2020.105091","article-title":"The three-phase enriched environment paradigm promotes neurovascular restorative and prevents learning impairment after ischemic stroke in rats","volume":"146","author":"Zhan","year":"2020","journal-title":"Neurobiology of Disease"},{"key":"10.1016\/j.brainres.2023.148619_b0260","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1016\/j.brainres.2016.11.001","article-title":"Effect of enriched environment on angiogenesis and neurological functions in rats with focal cerebral ischemia","volume":"1655","author":"Zhang","year":"2017","journal-title":"Brain Research"},{"issue":"3","key":"10.1016\/j.brainres.2023.148619_b0265","doi-asserted-by":"crossref","first-page":"1448","DOI":"10.1159\/000495593","article-title":"Alpha-lipoic acid preconditioning and ischaemic postconditioning synergistically protect rats from cerebral injury induced by ischemia and reperfusion partly via inhibition TLR4\/MyD88\/ NF-\u03baB signaling pathway","volume":"51","author":"Zhang","year":"2018","journal-title":"Cellular Physiology and Biochemistry"},{"issue":"7","key":"10.1016\/j.brainres.2023.148619_b0270","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1080\/00207454.2020.1797722","article-title":"Enriched environment improves post-stroke cognitive impairment and inhibits neuroinflammation and oxidative stress by activating Nrf2-ARE pathway","volume":"131","author":"Zhang","year":"2021","journal-title":"The International Journal of Neuroscience"},{"key":"10.1016\/j.brainres.2023.148619_b0275","doi-asserted-by":"crossref","DOI":"10.3389\/fnhum.2021.622911","article-title":"Differential effects of physical and social enriched environment on angiogenesis in male rats after cerebral ischemia\/reperfusion injury","volume":"15","author":"Zhang","year":"2021","journal-title":"Frontiers in Human Neuroscience"},{"issue":"11","key":"10.1016\/j.brainres.2023.148619_b0280","doi-asserted-by":"crossref","first-page":"2497","DOI":"10.4103\/1673-5374.338999","article-title":"An enriched environment reduces hippocampal inflammatory response and improves cognitive function in a mouse model of stroke","volume":"17","author":"Zhou","year":"2022","journal-title":"Neural Regeneration Research"},{"issue":"1","key":"10.1016\/j.brainres.2023.148619_b0285","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1186\/s12974-019-1538-9","article-title":"Ciprofloxacin and levofloxacin attenuate microglia inflammatory response via TLR4\/NF-kB pathway","volume":"16","author":"Zusso","year":"2019","journal-title":"Journal of Neuroinflammation"}],"container-title":["Brain Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006899323003906?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006899323003906?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,2]],"date-time":"2025-11-02T17:09:33Z","timestamp":1762103373000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006899323003906"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,12]]},"references-count":57,"alternative-id":["S0006899323003906"],"URL":"https:\/\/doi.org\/10.1016\/j.brainres.2023.148619","relation":{},"ISSN":["0006-8993"],"issn-type":[{"value":"0006-8993","type":"print"}],"subject":[],"published":{"date-parts":[[2023,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Enriched environment alleviates neurological deficits via downregulation of Cx43 after experimental stroke","name":"articletitle","label":"Article Title"},{"value":"Brain Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.brainres.2023.148619","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"148619"}}