{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T20:49:33Z","timestamp":1779310173181,"version":"3.51.4"},"reference-count":53,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,7,1]],"date-time":"2024-07-01T00:00:00Z","timestamp":1719792000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,7,1]],"date-time":"2024-07-01T00:00:00Z","timestamp":1719792000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,7,1]],"date-time":"2024-07-01T00:00:00Z","timestamp":1719792000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,7,1]],"date-time":"2024-07-01T00:00:00Z","timestamp":1719792000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,7,1]],"date-time":"2024-07-01T00:00:00Z","timestamp":1719792000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,7,1]],"date-time":"2024-07-01T00:00:00Z","timestamp":1719792000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,7,1]],"date-time":"2024-07-01T00:00:00Z","timestamp":1719792000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100004772","name":"Natural Science Foundation of Ningxia Province","doi-asserted-by":"publisher","award":["2022AAC03155"],"award-info":[{"award-number":["2022AAC03155"]}],"id":[{"id":"10.13039\/501100004772","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.fr","clinicalkey.jp","clinicalkey.com.au","clinicalkey.es","clinicalkey.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Brain Research"],"published-print":{"date-parts":[[2024,7]]},"DOI":"10.1016\/j.brainres.2024.148844","type":"journal-article","created":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T17:03:38Z","timestamp":1709312618000},"page":"148844","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"special_numbering":"C","title":["Inosine pretreatment of pregnant rats ameliorates maternal inflammation-mediated hypomyelination in pups via microglia polarization switch"],"prefix":"10.1016","volume":"1834","author":[{"given":"Yong","family":"Han","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jinping","family":"Sun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"family":"Xiaojuan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ma\u00b7Xin","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8254-2070","authenticated-orcid":false,"given":"Quanrui","family":"Ma","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.brainres.2024.148844_b0005","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1080\/13543784.2022.2040479","article-title":"Emerging neuroprotective interventions in periventricular leukomalacia - a systematic review of preclinical studies","volume":"31","author":"Abiramalatha","year":"2022","journal-title":"Expert Opin. Invest. Drugs"},{"key":"10.1016\/j.brainres.2024.148844_b0010","doi-asserted-by":"crossref","first-page":"37932","DOI":"10.1038\/srep37932","article-title":"Association between preterm brain injury and exposure to chorioamnionitis during fetal life","volume":"6","author":"Anblagan","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.brainres.2024.148844_b0015","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1007\/s00401-017-1718-6","article-title":"White matter injury in the preterm infant: pathology and mechanisms","volume":"134","author":"Back","year":"2017","journal-title":"Acta Neuropathol."},{"key":"10.1016\/j.brainres.2024.148844_b0020","doi-asserted-by":"crossref","first-page":"570","DOI":"10.1002\/jnr.10423","article-title":"Effects of intrauterine inflammation on developing rat brain","volume":"70","author":"Bell","year":"2002","journal-title":"J. Neurosci. Res."},{"key":"10.1016\/j.brainres.2024.148844_b0025","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1002\/mds.26483","article-title":"Oral inosine persistently elevates plasma antioxidant capacity in parkinson\u2019s disease","volume":"31","author":"Bhattacharyya","year":"2016","journal-title":"Mov. Disord."},{"key":"10.1016\/j.brainres.2024.148844_b0030","doi-asserted-by":"crossref","first-page":"12785","DOI":"10.1002\/jcb.28548","article-title":"In utero transplantation of neural stem cells ameliorates maternal inflammation-induced prenatal white matter injury","volume":"120","author":"Borhani-Haghighi","year":"2019","journal-title":"J. Cell. Biochem."},{"key":"10.1016\/j.brainres.2024.148844_b0035","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1038\/sj.sc.3102057","article-title":"Immunomodulatory effect of the purine nucleoside inosine following spinal cord contusion injury in rat","volume":"46","author":"Conta","year":"2008","journal-title":"Spinal Cord"},{"key":"10.1016\/j.brainres.2024.148844_b0040","doi-asserted-by":"crossref","first-page":"44861","DOI":"10.1038\/srep44861","article-title":"BDE-99 impairs differentiation of human and mouse NPCs into the oligodendroglial lineage by species-specific modes of action","volume":"7","author":"Dach","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.brainres.2024.148844_b0045","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1016\/j.brainres.2014.01.044","article-title":"Inosine improves functional recovery after experimental traumatic brain injury","volume":"1555","author":"Dachir","year":"2014","journal-title":"Brain Res."},{"key":"10.1016\/j.brainres.2024.148844_b0050","article-title":"Inosine attenuates post-stroke neuroinflammation by modulating inflammasome mediated microglial activation and polarization","volume":"166771","author":"Datta","year":"2023","journal-title":"Biochim. Biophys. Acta Mol. basis Dis."},{"key":"10.1016\/j.brainres.2024.148844_b0055","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1007\/s40120-018-0094-z","article-title":"ATX-MS-1467 induces long-term tolerance to myelin basic protein in (DR2 \u00d7 Ob1)F1 mice by induction of IL-10-secreting iTregs","volume":"7","author":"De Souza","year":"2018","journal-title":"Neurol Ther"},{"key":"10.1016\/j.brainres.2024.148844_b0060","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1007\/s002100000318","article-title":"Metabolic flux rates of adenosine in the heart","volume":"362","author":"Deussen","year":"2000","journal-title":"Naunyn Schmiedebergs Arch. Pharmacol."},{"key":"10.1016\/j.brainres.2024.148844_b0065","first-page":"71","article-title":"Oligodendrocyte, astrocyte, and microglia crosstalk in myelin development, damage, and repair","volume":"4","author":"Domingues","year":"2016","journal-title":"Front. Cell Dev. Biol."},{"key":"10.1016\/j.brainres.2024.148844_b0070","doi-asserted-by":"crossref","first-page":"1041","DOI":"10.1007\/s00210-019-01804-1","article-title":"The protective effect of inosine against rotenone-induced parkinson\u2019s disease in mice; role of oxido-nitrosative stress, ERK phosphorylation, and A2AR expression","volume":"393","author":"El-Shamarka","year":"2020","journal-title":"Naunyn Schmiedebergs Arch. Pharmacol."},{"key":"10.1016\/j.brainres.2024.148844_b0075","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1126\/science.1190927","article-title":"Regulation of oligodendrocyte differentiation and myelination","volume":"330","author":"Emery","year":"2010","journal-title":"Science"},{"key":"10.1016\/j.brainres.2024.148844_b0080","doi-asserted-by":"crossref","first-page":"2452","DOI":"10.1016\/j.cell.2022.06.008","article-title":"Mild respiratory COVID can cause multi-lineage neural cell and myelin dysregulation","volume":"185","author":"Fern\u00e1ndez-Casta\u00f1eda","year":"2022","journal-title":"Cell"},{"key":"10.1016\/j.brainres.2024.148844_b0085","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1177\/1352458509360547","article-title":"ASIIMS study group, Boosting endogenous neuroprotection in multiple sclerosis: the ASsociation of inosine and interferon beta in relapsing- remitting multiple sclerosis (ASIIMS) trial","volume":"16","author":"Gonsette","year":"2010","journal-title":"Mult. Scler."},{"key":"10.1016\/j.brainres.2024.148844_b0090","doi-asserted-by":"crossref","first-page":"7619","DOI":"10.1021\/acs.jafc.1c01781","article-title":"Protective effects of microbiome-derived inosine on lipopolysaccharide-induced acute liver damage and inflammation in mice via mediating the TLR4\/NF-\u03baB pathway","volume":"69","author":"Guo","year":"2021","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.brainres.2024.148844_b0095","doi-asserted-by":"crossref","first-page":"1055","DOI":"10.1038\/s41593-020-0654-2","article-title":"Microglia phagocytose myelin sheaths to modify developmental myelination","volume":"23","author":"Hughes","year":"2020","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.brainres.2024.148844_b0100","doi-asserted-by":"crossref","DOI":"10.1016\/j.expneurol.2022.114229","article-title":"Placental mediated mechanisms of perinatal brain injury","volume":"358","author":"Jantzie","year":"2022","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.brainres.2024.148844_b0105","doi-asserted-by":"crossref","first-page":"946","DOI":"10.2967\/jnumed.106.038539","article-title":"Microglial activation in perinatal rabbit brain induced by intrauterine inflammation: detection with 11C-(R)-PK11195 and small-animal PET","volume":"48","author":"Kannan","year":"2007","journal-title":"J. Nucl. Med."},{"key":"10.1016\/j.brainres.2024.148844_b0110","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1038\/s41582-023-00801-6","article-title":"Inflammation in multiple sclerosis: consequences for remyelination and disease progression","volume":"19","author":"Klotz","year":"2023","journal-title":"Nat. Rev. Neurol."},{"key":"10.1016\/j.brainres.2024.148844_b0115","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1159\/000105493","article-title":"Erythropoietin attenuates lipopolysaccharide-induced white matter injury in the neonatal rat brain","volume":"92","author":"Kumral","year":"2007","journal-title":"Neonatology"},{"key":"10.1016\/j.brainres.2024.148844_b0120","doi-asserted-by":"crossref","DOI":"10.3389\/fcimb.2021.697640","article-title":"Impact of inosine on chronic unpredictable mild stress-induced depressive and anxiety-like behaviors with the alteration of gut microbiota","volume":"11","author":"Liu","year":"2021","journal-title":"Front. Cell. Infect. Microbiol."},{"key":"10.1016\/j.brainres.2024.148844_b0125","doi-asserted-by":"crossref","first-page":"2830","DOI":"10.3390\/nu14142830","article-title":"Inosine pretreatment attenuates LPS-induced lung injury through regulating the TLR4\/MyD88\/NF-\u03baB signaling pathway in vivo","volume":"14","author":"Mao","year":"2022","journal-title":"Nutrients"},{"key":"10.1016\/j.brainres.2024.148844_b0130","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1016\/j.bbadis.2010.09.010","article-title":"Cells of the oligodendroglial lineage, myelination, and remyelination","volume":"1812","author":"Miron","year":"2011","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.brainres.2024.148844_b0135","doi-asserted-by":"crossref","first-page":"1211","DOI":"10.1038\/nn.3469","article-title":"M2 microglia and macrophages drive oligodendrocyte differentiation during CNS remyelination","volume":"16","author":"Miron","year":"2013","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.brainres.2024.148844_b0140","article-title":"Neuron to oligodendrocyte precursor cell synapses: protagonists in oligodendrocyte development and myelination, and targets for therapeutics","volume":"15","author":"Moura","year":"2021","journal-title":"Front. Neurosci."},{"key":"10.1016\/j.brainres.2024.148844_b0145","doi-asserted-by":"crossref","DOI":"10.3389\/fnins.2021.703783","article-title":"Inosine as a tool to understand and treat central nervous system disorders: a neglected actor?","volume":"15","author":"Nascimento","year":"2021","journal-title":"Front. Neurosci."},{"key":"10.1016\/j.brainres.2024.148844_b0150","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1146\/annurev-immunol-032713-120240","article-title":"Microglia development and function","volume":"32","author":"Nayak","year":"2014","journal-title":"Annu. Rev. Immunol."},{"key":"10.1016\/j.brainres.2024.148844_b0155","doi-asserted-by":"crossref","first-page":"1835","DOI":"10.1177\/1352458519884006","article-title":"Remyelination and ageing: reversing the ravages of time","volume":"25","author":"Neumann","year":"2019","journal-title":"Mult. Scler."},{"key":"10.1016\/j.brainres.2024.148844_b0160","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1016\/j.bbi.2014.02.007","article-title":"Maternal immune activation leads to activated inflammatory macrophages in offspring","volume":"38","author":"Onore","year":"2014","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.brainres.2024.148844_b0165","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/S0006-8993(03)02980-9","article-title":"Use of a three-dimensional in vitro model of the rat blood-brain barrier to assay nucleoside efflux from brain","volume":"980","author":"Parkinson","year":"2003","journal-title":"Brain Res."},{"key":"10.1016\/j.brainres.2024.148844_b0170","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/j.tibs.2016.09.009","article-title":"A new view into the regulation of purine metabolism: the purinosome","volume":"42","author":"Pedley","year":"2017","journal-title":"Trends Biochem. Sci"},{"key":"10.1016\/j.brainres.2024.148844_b0175","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1146\/annurev-pathol-011811-132443","article-title":"Pathology of demyelinating diseases","volume":"7","author":"Popescu","year":"2012","journal-title":"Annu. Rev. Pathol."},{"key":"10.1016\/j.brainres.2024.148844_b0180","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1016\/j.clp.2009.06.003","article-title":"Disorders of placental circulation and the fetal brain","volume":"36","author":"Redline","year":"2009","journal-title":"Clin. Perinatol."},{"key":"10.1016\/j.brainres.2024.148844_b0185","first-page":"57","article-title":"Prevalence and risk factors for periventricular leukomalacia in preterm infants. a systematic review","volume":"65","author":"Romero-Guzman","year":"2017","journal-title":"Rev. Neurol."},{"key":"10.1016\/j.brainres.2024.148844_b0190","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1053\/siny.2001.0043","article-title":"Cerebral white matter damage in the preterm infant: pathophysiology and risk factors","volume":"6","author":"Saliba","year":"2001","journal-title":"Semin. Neonatol."},{"key":"10.1016\/j.brainres.2024.148844_b0195","doi-asserted-by":"crossref","first-page":"991","DOI":"10.1002\/jnr.24761","article-title":"White matter injury in the neonatal hypoxic-ischemic brain and potential therapies targeting microglia","volume":"99","author":"Shao","year":"2021","journal-title":"J. Neurosci. Res."},{"key":"10.1016\/j.brainres.2024.148844_b0200","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1038\/jhh.2009.83","article-title":"Modulation of serum uric acid levels by inosine in patients with multiple sclerosis does not affect blood pressure","volume":"24","author":"Spitsin","year":"2010","journal-title":"J. Hum. Hypertens."},{"key":"10.1016\/j.brainres.2024.148844_b0205","first-page":"671","article-title":"The role of microglia in brain injury","volume":"17","author":"Streit","year":"1996","journal-title":"Neurotoxicology"},{"key":"10.1016\/j.brainres.2024.148844_b0210","doi-asserted-by":"crossref","first-page":"79","DOI":"10.3389\/fncel.2020.00079","article-title":"Astrocytes and microglia as major players of myelin production in Normal and pathological conditions","volume":"14","author":"Traiffort","year":"2020","journal-title":"Front. Cell. Neurosci."},{"key":"10.1016\/j.brainres.2024.148844_b0215","doi-asserted-by":"crossref","first-page":"849","DOI":"10.3109\/14767058.2011.587917","article-title":"Maternal omega-3 fatty acid supplementation protects against lipopolysaccharide-induced white matter injury in the neonatal rat brain","volume":"25","author":"Tuzun","year":"2012","journal-title":"J. Matern. Fetal Neonatal Med."},{"key":"10.1016\/j.brainres.2024.148844_b0220","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1542\/peds.112.1.176","article-title":"Cerebral white matter injury of the premature infant-more common than you think","volume":"112","author":"Volpe","year":"2003","journal-title":"Pediatrics"},{"key":"10.1016\/j.brainres.2024.148844_b0225","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1016\/S1474-4422(08)70294-1","article-title":"Brain injury in premature infants: a complex amalgam of destructive and developmental disturbances","volume":"8","author":"Volpe","year":"2009","journal-title":"Lancet Neurol."},{"key":"10.1016\/j.brainres.2024.148844_b0230","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1093\/brain\/awu375","article-title":"Gain of Olig2 function in oligodendrocyte progenitors promotes remyelination","volume":"138","author":"Wegener","year":"2015","journal-title":"Brain"},{"key":"10.1016\/j.brainres.2024.148844_b0235","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1016\/j.cellsig.2017.11.002","article-title":"Enhancement of inosine-mediated A2AR signaling through positive allosteric modulation","volume":"42","author":"Welihinda","year":"2018","journal-title":"Cell. Signal."},{"key":"10.1016\/j.brainres.2024.148844_b0240","article-title":"The optimal choices of animal models of white matter injury","volume":"30","author":"Y, z., h, w., l, z., j, t., j, s., d, x., y, q., d, m.,","year":"2019","journal-title":"Rev. Neurosci."},{"issue":"Suppl 20","key":"10.1016\/j.brainres.2024.148844_b0245","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1046\/j.1471-0528.2003.00063.x","article-title":"Intrauterine infection and the development of cerebral palsy","volume":"110","author":"Yoon","year":"2003","journal-title":"BJOG"},{"key":"10.1016\/j.brainres.2024.148844_b0250","doi-asserted-by":"crossref","first-page":"930","DOI":"10.3389\/fneur.2020.00930","article-title":"Intranasal IL-4 administration alleviates functional deficits of periventricular leukomalacia in neonatal mice","volume":"11","author":"Yu","year":"2020","journal-title":"Front. Neurol."},{"key":"10.1016\/j.brainres.2024.148844_b0255","doi-asserted-by":"crossref","first-page":"5977","DOI":"10.1523\/JNEUROSCI.4498-10.2011","article-title":"Inosine augments the effects of a nogo receptor blocker and of environmental enrichment to restore skilled forelimb use after stroke","volume":"31","author":"Zai","year":"2011","journal-title":"J. Neurosci."},{"key":"10.1016\/j.brainres.2024.148844_b0260","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/j.brainresbull.2022.08.014","article-title":"MicroRNA-21-5p agomir inhibits apoptosis of oligodendrocyte precursor cell and attenuates white matter injury in neonatal rats","volume":"189","author":"Zhang","year":"2022","journal-title":"Brain Res. Bull."},{"key":"10.1016\/j.brainres.2024.148844_b0265","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1038\/s41380-020-00930-0","article-title":"Oligodendrocyte lineage cells and depression","volume":"26","author":"Zhou","year":"2021","journal-title":"Mol. Psychiatry"}],"container-title":["Brain Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006899324000982?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006899324000982?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,5,8]],"date-time":"2024-05-08T01:02:04Z","timestamp":1715130124000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006899324000982"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,7]]},"references-count":53,"alternative-id":["S0006899324000982"],"URL":"https:\/\/doi.org\/10.1016\/j.brainres.2024.148844","relation":{},"ISSN":["0006-8993"],"issn-type":[{"value":"0006-8993","type":"print"}],"subject":[],"published":{"date-parts":[[2024,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Inosine pretreatment of pregnant rats ameliorates maternal inflammation-mediated hypomyelination in pups via microglia polarization switch","name":"articletitle","label":"Article Title"},{"value":"Brain Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.brainres.2024.148844","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"148844"}}