{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,2]],"date-time":"2026-11-02T18:01:16Z","timestamp":1793642476269,"version":"4.5.1"},"reference-count":225,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,7,1]],"date-time":"2024-07-01T00:00:00Z","timestamp":1719792000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,7,1]],"date-time":"2024-07-01T00:00:00Z","timestamp":1719792000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,7,1]],"date-time":"2024-07-01T00:00:00Z","timestamp":1719792000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,7,1]],"date-time":"2024-07-01T00:00:00Z","timestamp":1719792000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,7,1]],"date-time":"2024-07-01T00:00:00Z","timestamp":1719792000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,7,1]],"date-time":"2024-07-01T00:00:00Z","timestamp":1719792000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,7,1]],"date-time":"2024-07-01T00:00:00Z","timestamp":1719792000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["clinicalkey.fr","clinicalkey.jp","clinicalkey.com.au","clinicalkey.es","clinicalkey.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Brain Research"],"published-print":{"date-parts":[[2024,7]]},"DOI":"10.1016\/j.brainres.2024.148886","type":"journal-article","created":{"date-parts":[[2024,4,4]],"date-time":"2024-04-04T15:21:52Z","timestamp":1712244112000},"page":"148886","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":25,"special_numbering":"C","title":["Alkaloids as drug leads in Alzheimer's treatment: Mechanistic and therapeutic insights"],"prefix":"10.1016","volume":"1834","author":[{"given":"Md.","family":"Rezaul Islam","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shopnil","family":"Akash","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammed","family":"Murshedul Islam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nadia","family":"Sarkar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ajoy","family":"Kumer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandip","family":"Chakraborty","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kuldeep","family":"Dhama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Majed","family":"Ahmed Al-Shaeri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasir","family":"Anwar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Polrat","family":"Wilairatana","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdur","family":"Rauf","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6632-0646","authenticated-orcid":false,"given":"Ibrahim F.","family":"Halawani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fuad M.","family":"Alzahrani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haroon","family":"Khan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.brainres.2024.148886_b0005","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1472-6882-13-218","article-title":"In vitro biological assessment of Berberis vulgaris and its active constituent, berberine: antioxidants, anti-acetylcholinesterase, anti-diabetic and anticancer effects","volume":"13","author":"Abd El-Wahab","year":"2013","journal-title":"BMC Complement. Altern. Med."},{"key":"10.1016\/j.brainres.2024.148886_b0010","article-title":"Recent developments on synthesis strategies, SAR studies and biological activities of \u03b2-Carboline derivatives\u2013an update","volume":"132750","author":"Abinaya","year":"2022","journal-title":"J. Mol. Struct."},{"key":"10.1016\/j.brainres.2024.148886_b0015","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1515\/hc-2022-0013","article-title":"Synthesis of enhanced lipid solubility of indomethacin derivatives for topical formulations","volume":"28","author":"Abualhasan","year":"2022","journal-title":"Heterocycl. Commun."},{"key":"10.1016\/j.brainres.2024.148886_b0020","doi-asserted-by":"crossref","first-page":"2766","DOI":"10.2174\/138161210793176572","article-title":"Neuroinflammation, oxidative stress and the pathogenesis of Alzheimer's disease","volume":"16","author":"Agostinho","year":"2010","journal-title":"Curr. Pharm. Des."},{"key":"10.1016\/j.brainres.2024.148886_b0025","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1007\/s12640-020-00205-0","article-title":"Curcumin administration mitigates cyclophosphamide-induced oxidative damage and restores alteration of enzymes associated with cognitive function in rats\u2019 brain","volume":"38","author":"Akomolafe","year":"2020","journal-title":"Neurotox. Res."},{"key":"10.1016\/j.brainres.2024.148886_b0030","doi-asserted-by":"crossref","first-page":"800","DOI":"10.3390\/biom10050800","article-title":"Amaryllidaceae alkaloids of belladine-type from Narcissus pseudonarcissus cv. carlton as new selective inhibitors of butyrylcholinesterase","volume":"10","author":"Al Mamun","year":"2020","journal-title":"Biomolecules"},{"key":"10.1016\/j.brainres.2024.148886_b0035","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/j.sajb.2020.06.024","article-title":"Amaryllidaceae alkaloids from Hippeastrum X hybridum CV. Ferrari, and preparation of vittatine derivatives as potential ligands for Alzheime\u0155 s disease","volume":"136","author":"Al Shammari","year":"2021","journal-title":"S. Afr. J. Bot."},{"key":"10.1016\/j.brainres.2024.148886_b0040","doi-asserted-by":"crossref","first-page":"1345","DOI":"10.2741\/4285","article-title":"An update on drug treatment options of Alzheimer\u2019s disease","volume":"19","author":"Allgaier","year":"2014","journal-title":"Front Biosci (landmark Ed)."},{"key":"10.1016\/j.brainres.2024.148886_b0045","article-title":"Lifestyle strategies to promote proteostasis and reduce the risk of Alzheimer\u2019s disease and other proteinopathies","volume":"102162","author":"Almeida","year":"2023","journal-title":"Ageing Res. Rev."},{"key":"10.1016\/j.brainres.2024.148886_b0050","doi-asserted-by":"crossref","first-page":"488","DOI":"10.2174\/092986708783503203","article-title":"Pathways of acetylcholine synthesis, transport and release as targets for treatment of adult-onset cognitive dysfunction","volume":"15","author":"Amenta","year":"2008","journal-title":"Curr. Med. Chem."},{"key":"10.1016\/j.brainres.2024.148886_b0055","doi-asserted-by":"crossref","DOI":"10.1016\/j.phytol.2014.06.015","article-title":"Alkaloids as drug leads\u2013a predictive structural and biodiversity-based analysis","volume":"10","author":"Amirkia","year":"2014","journal-title":"Phytochem. Lett."},{"key":"10.1016\/j.brainres.2024.148886_b0060","doi-asserted-by":"crossref","first-page":"1401","DOI":"10.1007\/s00894-010-0841-2","article-title":"Docking of the alkaloid geissospermine into acetylcholinesterase: a natural scaffold targeting the treatment of Alzheimer\u2019s disease","volume":"17","author":"Ara\u00fajo","year":"2011","journal-title":"J. Mol. Model."},{"key":"10.1016\/j.brainres.2024.148886_b0065","doi-asserted-by":"crossref","first-page":"661","DOI":"10.3233\/JAD-2009-1087","article-title":"Caffeine reverses cognitive impairment and decreases brain amyloid-\u03b2 levels in aged Alzheimer's disease mice","volume":"17","author":"Arendash","year":"2009","journal-title":"J. Alzheimers Dis."},{"key":"10.1016\/j.brainres.2024.148886_b0070","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1097\/00002093-199509040-00009","article-title":"Treatment of Alzheimer disease by continuous intravenous infusion of physostigmine","volume":"9","author":"Asthana","year":"1995","journal-title":"Alzheimer Dis. Assoc. Disord."},{"key":"10.1016\/j.brainres.2024.148886_b0075","doi-asserted-by":"crossref","first-page":"1045","DOI":"10.1016\/j.steroids.2006.09.002","article-title":"New bioactive steroidal alkaloids from Buxus hyrcana","volume":"71","author":"Babar","year":"2006","journal-title":"Steroids"},{"key":"10.1016\/j.brainres.2024.148886_b0080","series-title":"Neurodegenerative disease conditions and genomic treatment for better health","first-page":"281","author":"Badhe","year":"2018"},{"key":"10.1016\/j.brainres.2024.148886_b0085","doi-asserted-by":"crossref","first-page":"187","DOI":"10.22270\/jddt.v10i1-s.3866","article-title":"Physostigmine: a plant alkaloid isolated from Physostigma venenosum: a review on pharmacokinetics, pharmacological and toxicological activities","volume":"10","author":"Batiha","year":"2020","journal-title":"Journal of Drug Delivery and Therapeutics."},{"key":"10.1016\/j.brainres.2024.148886_b0090","doi-asserted-by":"crossref","first-page":"4927","DOI":"10.2147\/IJN.S35333","article-title":"Indomethacin-loaded lipid-core nanocapsules reduce the damage triggered by A\u03b21-42 in Alzheimer\u2019s disease models","author":"Bernardi","year":"2012","journal-title":"Int. J. Nanomed."},{"key":"10.1016\/j.brainres.2024.148886_b0095","doi-asserted-by":"crossref","first-page":"1098","DOI":"10.1039\/c2md20076g","article-title":"Total synthesis and anti-cholinesterase activity of marine-derived bis-indole alkaloid fascaplysin","volume":"3","author":"Bharate","year":"2012","journal-title":"MedChemComm."},{"key":"10.1016\/j.brainres.2024.148886_b0100","first-page":"1185","article-title":"Mesoionic sydnone derivatives: an overview","volume":"4","author":"Bhosale","year":"2012","journal-title":"J. Chem. Pharm. Res."},{"key":"10.1016\/j.brainres.2024.148886_b0105","doi-asserted-by":"crossref","first-page":"e2000186","DOI":"10.1002\/cbdv.202000186","article-title":"Recent advances on marine alkaloids from sponges","volume":"17","author":"Bian","year":"2020","journal-title":"Chem. Biodivers."},{"key":"10.1016\/j.brainres.2024.148886_b0110","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1016\/0028-3908(91)90005-V","article-title":"Galanthamine: pharmacokinetics, tissue distribution and cholinesterase inhibition in brain of mice","volume":"30","author":"Bickel","year":"1991","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.brainres.2024.148886_b0115","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1111\/j.1474-9728.2004.00101.x","article-title":"How chronic inflammation can affect the brain and support the development of Alzheimer's disease in old age: the role of microglia and astrocytes","volume":"3","author":"Blasko","year":"2004","journal-title":"Aging Cell"},{"key":"10.1016\/j.brainres.2024.148886_b0120","doi-asserted-by":"crossref","first-page":"1726","DOI":"10.1111\/jphp.12172","article-title":"Berberis aetnensis and B. libanotica: a comparative study on the chemical composition, inhibitory effect on key enzymes linked to Alzheimer's disease and antioxidant activity","volume":"65","author":"Bonesi","year":"2013","journal-title":"J. Pharm. Pharmacol."},{"key":"10.1016\/j.brainres.2024.148886_b0125","first-page":"728","article-title":"Pharmacological evaluation of novel Alzheimer's disease therapeutics: acetylcholinesterase inhibitors related to galanthamine","volume":"277","author":"Bores","year":"1996","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.brainres.2024.148886_b0130","series-title":"Network dysfunction in Alzheimer's disease: the Interaction of brain networks and neurodegeneration","author":"Brier","year":"2017"},{"key":"10.1016\/j.brainres.2024.148886_b0135","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1002\/cbdv.200490064","article-title":"Screening of non-alkaloidal natural compounds as acetylcholinesterase inhibitors","volume":"1","author":"Br\u00fchlmann","year":"2004","journal-title":"Chem. Biodivers."},{"key":"10.1016\/j.brainres.2024.148886_b0140","doi-asserted-by":"crossref","first-page":"6669","DOI":"10.1016\/j.bmc.2012.09.040","article-title":"Exploration of natural compounds as sources of new bifunctional scaffolds targeting cholinesterases and beta amyloid aggregation: the case of chelerythrine","volume":"20","author":"Brunhofer","year":"2012","journal-title":"Bioorg. Med. Chem."},{"key":"10.1016\/j.brainres.2024.148886_b0145","doi-asserted-by":"crossref","first-page":"S8","DOI":"10.1038\/475S8a","article-title":"Perspective: in search of biomarkers","volume":"475","author":"Buckholtz","year":"2011","journal-title":"Nature"},{"key":"10.1016\/j.brainres.2024.148886_b0150","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1080\/14786419.2012.701217","article-title":"Lycopodiaceae from Panama: a new source of acetylcholinesterase inhibitors","volume":"27","author":"Calder\u00f3n","year":"2013","journal-title":"Nat. Prod. Res."},{"key":"10.1016\/j.brainres.2024.148886_b0155","doi-asserted-by":"crossref","first-page":"71","DOI":"10.2174\/1570159X13666141210215655","article-title":"Caffeine: cognitive and physical performance enhancer or psychoactive drug?","volume":"13","author":"Cappelletti","year":"2015","journal-title":"Curr. Neuropharmacol."},{"key":"10.1016\/j.brainres.2024.148886_b0160","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1177\/014107680409700614","article-title":"Medicinal uses of tobacco in history","volume":"97","author":"Charlton","year":"2004","journal-title":"J. R. Soc. Med."},{"key":"10.1016\/j.brainres.2024.148886_b0165","doi-asserted-by":"crossref","first-page":"2689","DOI":"10.1016\/j.bmcl.2004.10.098","article-title":"Synthesis of linked berberine dimers and their remarkably enhanced DNA-binding affinities","volume":"15","author":"Chen","year":"2005","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.brainres.2024.148886_b0170","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1007\/s11011-014-9580-x","article-title":"Berberine protects homocysteic acid-induced HT-22 cell death: involvement of akt pathway","volume":"30","author":"Chen","year":"2015","journal-title":"Metab. Brain Dis."},{"key":"10.1016\/j.brainres.2024.148886_b0175","doi-asserted-by":"crossref","first-page":"798","DOI":"10.1016\/j.fct.2009.12.009","article-title":"Piperine, the main alkaloid of thai black pepper, protects against neurodegeneration and cognitive impairment in animal model of cognitive deficit like condition of Alzheimer\u2019s disease","volume":"48","author":"Chonpathompikunlert","year":"2010","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.brainres.2024.148886_b0180","doi-asserted-by":"crossref","first-page":"1703","DOI":"10.1016\/j.bmc.2006.12.005","article-title":"Carinatumins A-C, new alkaloids from Lycopodium carinatum inhibiting acetylcholinesterase","volume":"15","author":"Choo","year":"2007","journal-title":"Bioorg. Med. Chem."},{"key":"10.1016\/j.brainres.2024.148886_b0185","doi-asserted-by":"crossref","first-page":"2095","DOI":"10.1016\/j.foodchem.2012.04.148","article-title":"Crude caffeine reduces memory impairment and amyloid \u03b21\u201342 levels in an Alzheimer\u2019s mouse model","volume":"135","author":"Chu","year":"2012","journal-title":"Food Chem."},{"key":"10.1016\/j.brainres.2024.148886_b0190","article-title":"Physostigmine for Alzheimer's disease","author":"Coelho","year":"2001","journal-title":"Cochrane Database Syst. Rev."},{"key":"10.1016\/j.brainres.2024.148886_b0195","volume":"Vol.","author":"Connelly","year":"2014"},{"key":"10.1016\/j.brainres.2024.148886_b0200","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1089\/10762800152709741","article-title":"The plant alkaloid galantamine: approved as a drug; sold as a supplement","volume":"7","author":"Cronin","year":"2001","journal-title":"Alternative & Complementary Therapies."},{"key":"10.1016\/j.brainres.2024.148886_b0205","doi-asserted-by":"crossref","first-page":"276","DOI":"10.25518\/0037-9565.6494","article-title":"Contribution \u00e0 l\u2019\u00e9tude phytochimique d\u2019une plante m\u00e9dicinale (ammoides verticillata desf. briq.) de l\u2019Est alg\u00e9rien","volume":"85","author":"Daira","year":"2016","journal-title":"Bull. Soc. Roy. Sci. Li\u00e8ge"},{"key":"10.1016\/j.brainres.2024.148886_b0215","first-page":"19","article-title":"Plant-derived acetylcholinesterase inhibitory alkaloids for the treatment of Alzheimer's disease","volume":"3","author":"Dall'Acqua","year":"2013","journal-title":"Botanics: Targets and Therapy."},{"key":"10.1016\/j.brainres.2024.148886_b0220","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1016\/j.expneurol.2006.08.008","article-title":"Caffeine and adenosine A2a receptor antagonists prevent \u03b2-amyloid (25\u201335)-induced cognitive deficits in mice","volume":"203","author":"Dall'Igna","year":"2007","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.brainres.2024.148886_b0225","doi-asserted-by":"crossref","first-page":"161","DOI":"10.4172\/2167-0412.1000161","article-title":"A review on therapeutic potential of Piper nigrum L. black pepper): the king of spices","volume":"3","author":"Damanhouri","year":"2014","journal-title":"Med. Aromat. Plants."},{"key":"10.1016\/j.brainres.2024.148886_b0230","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1080\/14737175.2016.1175303","article-title":"Huperzine a as a neuroprotective and antiepileptic drug: a review of preclinical research","volume":"16","author":"Damar","year":"2016","journal-title":"Expert Rev. Neurother."},{"key":"10.1016\/j.brainres.2024.148886_b0235","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.pbi.2014.03.006","article-title":"Making iridoids\/secoiridoids and monoterpenoid indole alkaloids: progress on pathway elucidation","volume":"19","author":"De Luca","year":"2014","journal-title":"Curr. Opin. Plant Biol."},{"key":"10.1016\/j.brainres.2024.148886_b0240","doi-asserted-by":"crossref","first-page":"612","DOI":"10.1039\/b704958g","article-title":"Terpenoid alkaloids of the Buxaceae family with potential biological importance","volume":"25","author":"Devkota","year":"2008","journal-title":"Nat. Prod. Rep."},{"key":"10.1016\/j.brainres.2024.148886_b0245","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1016\/j.nbd.2010.03.022","article-title":"Indirubin-3'-monoxime rescues spatial memory deficits and attenuates \u03b2-amyloid-associated neuropathology in a mouse model of Alzheimer's disease","volume":"39","author":"Ding","year":"2010","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.brainres.2024.148886_b0250","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1080\/10286020.2016.1198332","article-title":"Phytochemical and biological investigations of Amaryllidaceae alkaloids: a review","volume":"19","author":"Ding","year":"2017","journal-title":"J. Asian Nat. Prod. Res."},{"key":"10.1016\/j.brainres.2024.148886_b0255","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1080\/02791072.2016.1260189","article-title":"Effects of the natural \u03b2-carboline alkaloid harmine, a main constituent of ayahuasca, in memory and in the hippocampus: a systematic literature review of preclinical studies","volume":"49","author":"Dos Santos","year":"2017","journal-title":"J. Psychoact. Drugs"},{"key":"10.1016\/j.brainres.2024.148886_b0260","doi-asserted-by":"crossref","first-page":"2903","DOI":"10.1016\/j.neurobiolaging.2012.02.016","article-title":"Berberine ameliorates \u03b2-amyloid pathology, gliosis, and cognitive impairment in an Alzheimer's disease transgenic mouse model","volume":"33","author":"Durairajan","year":"2012","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.brainres.2024.148886_b0265","doi-asserted-by":"crossref","first-page":"e92954","DOI":"10.1371\/journal.pone.0092954","article-title":"Effects of huanglian-jie-du-tang and its modified formula on the modulation of amyloid-\u03b2 precursor protein processing in Alzheimer's disease models","volume":"9","author":"Durairajan","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.brainres.2024.148886_b0270","doi-asserted-by":"crossref","first-page":"989","DOI":"10.1016\/0140-6736(91)92656-M","article-title":"Tacrine in Alzheimer's disease","volume":"337","author":"Eagger","year":"1991","journal-title":"Lancet"},{"key":"10.1016\/j.brainres.2024.148886_b0275","doi-asserted-by":"crossref","first-page":"817","DOI":"10.3233\/JAD-2011-102136","article-title":"Cotinine reduces amyloid-\u03b2 aggregation and improves memory in Alzheimer's disease mice","volume":"24","author":"Echeverria","year":"2011","journal-title":"J. Alzheimers Dis."},{"key":"10.1016\/j.brainres.2024.148886_b0280","doi-asserted-by":"crossref","first-page":"1082","DOI":"10.1016\/j.neuropharm.2011.10.022","article-title":"Galantamine elicits neuroprotection by inhibiting iNOS, NADPH oxidase and ROS in hippocampal slices stressed with anoxia\/reoxygenation","volume":"62","author":"Egea","year":"2012","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.brainres.2024.148886_b0285","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1007\/s00432-004-0579-2","article-title":"Molecular mechanisms of indirubin and its derivatives: novel anticancer molecules with their origin in traditional chinese phytomedicine","volume":"130","author":"Eisenbrand","year":"2004","journal-title":"J. Cancer Res. Clin. Oncol."},{"key":"10.1016\/j.brainres.2024.148886_b0290","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1055\/s-2004-818919","article-title":"Acetylcholinesterase enzyme inhibitory effects of Amaryllidaceae alkaloids","volume":"70","author":"Elgorashi","year":"2004","journal-title":"Planta Med."},{"key":"10.1016\/j.brainres.2024.148886_b0295","doi-asserted-by":"crossref","first-page":"836","DOI":"10.2174\/138955711796575434","article-title":"An overview on natural cholinesterase inhibitors-a multi-targeted drug class-and their mass production","volume":"11","author":"Erdogan Orhan","year":"2011","journal-title":"Mini Rev. Med. Chem."},{"key":"10.1016\/j.brainres.2024.148886_b0300","doi-asserted-by":"crossref","first-page":"608","DOI":"10.2174\/156720511796717258","article-title":"Mechanisms of tau self-aggregation and neurotoxicity","volume":"8","author":"Farias","year":"2011","journal-title":"Curr. Alzheimer Res."},{"key":"10.1016\/j.brainres.2024.148886_b0305","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1016\/j.steroids.2004.03.016","article-title":"New pregnane-type steroidal alkaloids from Sarcococca saligna and their cholinesterase inhibitory activity","volume":"69","author":"Feroz","year":"2004","journal-title":"Steroids"},{"key":"10.1016\/j.brainres.2024.148886_b0310","first-page":"11","article-title":"Distribution, biosynthesis and catabolism of methylxanthines in plants","author":"Fredholm","year":"2011","journal-title":"Methylxanthines."},{"key":"10.1016\/j.brainres.2024.148886_b0315","doi-asserted-by":"crossref","first-page":"e19264","DOI":"10.1371\/journal.pone.0019264","article-title":"\u03b2-carboline compounds, including harmine, inhibit DYRK1A and tau phosphorylation at multiple Alzheimer's disease-related sites","volume":"6","author":"Frost","year":"2011","journal-title":"PLoS One"},{"key":"10.1016\/j.brainres.2024.148886_b0320","doi-asserted-by":"crossref","first-page":"9959","DOI":"10.1073\/pnas.1405803111","article-title":"Blockade of EphA4 signaling ameliorates hippocampal synaptic dysfunctions in mouse models of Alzheimer\u2019s disease","volume":"111","author":"Fu","year":"2014","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1016\/j.brainres.2024.148886_b0325","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1002\/jnr.20891","article-title":"Uncaria rhynchophylla, a chinese medicinal herb, has potent antiaggregation effects on Alzheimer's \u03b2-amyloid proteins","volume":"84","author":"Fujiwara","year":"2006","journal-title":"J. Neurosci. Res."},{"key":"10.1016\/j.brainres.2024.148886_b0330","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1517\/13543776.2015.1019865","article-title":"Indirubin derivatives: a patent review (2010\u2013present)","volume":"25","author":"Gaboriaud-Kolar","year":"2015","journal-title":"Expert Opin. Ther. Pat."},{"key":"10.1016\/j.brainres.2024.148886_b0335","doi-asserted-by":"crossref","first-page":"1048","DOI":"10.1002\/jnr.20791","article-title":"Huperzine a attenuates mitochondrial dysfunction in \u03b2-amyloid-treated PC12 cells by reducing oxygen free radicals accumulation and improving mitochondrial energy metabolism","volume":"83","author":"Gao","year":"2006","journal-title":"J. Neurosci. Res."},{"key":"10.1016\/j.brainres.2024.148886_b0340","doi-asserted-by":"crossref","first-page":"1454","DOI":"10.1016\/j.freeradbiomed.2009.02.028","article-title":"Huperzine a protects isolated rat brain mitochondria against \u03b2-amyloid peptide","volume":"46","author":"Gao","year":"2009","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.brainres.2024.148886_b0345","doi-asserted-by":"crossref","first-page":"2173","DOI":"10.1016\/j.bmc.2010.01.074","article-title":"Acetylcholinesterase inhibitors from the toadstool Cortinarius infractus","volume":"18","author":"Geissler","year":"2010","journal-title":"Bioorg. Med. Chem."},{"key":"10.1016\/j.brainres.2024.148886_b0350","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1586\/14737175.4.1.5","article-title":"Donepezil (aricept\u00ae) for treatment of Alzheime\u0155 s disease and other dementing conditions","volume":"4","author":"Geldmacher","year":"2004","journal-title":"Expert Rev. Neurother."},{"key":"10.1016\/j.brainres.2024.148886_b0355","series-title":"The health benefits of smoking cessation","first-page":"11","author":"General","year":"1990"},{"key":"10.1016\/j.brainres.2024.148886_b0360","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/j.pneurobio.2013.10.004","article-title":"Autophagy and apoptosis dysfunction in neurodegenerative disorders","volume":"112","author":"Ghavami","year":"2014","journal-title":"Prog. Neurobiol."},{"key":"10.1016\/j.brainres.2024.148886_b0365","doi-asserted-by":"crossref","first-page":"2141","DOI":"10.1016\/S0031-9422(00)83001-0","article-title":"Crinum alkaloids: their chemistry and biology","volume":"24","author":"Ghosal","year":"1985","journal-title":"Phytochemistry"},{"key":"10.1016\/j.brainres.2024.148886_b0370","doi-asserted-by":"crossref","first-page":"6324","DOI":"10.1111\/j.1742-4658.2009.07346.x","article-title":"Harmine specifically inhibits protein kinase DYRK1A and interferes with neurite formation","volume":"276","author":"G\u00f6ckler","year":"2009","journal-title":"FEBS J."},{"key":"10.1016\/j.brainres.2024.148886_b0375","doi-asserted-by":"crossref","first-page":"1246","DOI":"10.1111\/j.1476-5381.2011.01713.x","article-title":"Tau-targeted treatment strategies in Alzheimer's disease","volume":"165","author":"G\u00f6tz","year":"2012","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.brainres.2024.148886_b0380","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1023\/A:1022971430463","article-title":"Phenolic compounds on the pod-surface of pigeonpea, Cajanus cajan, mediate feeding behavior of Helicoverpa armigera larvae","volume":"29","author":"Green","year":"2003","journal-title":"J. Chem. Ecol."},{"key":"10.1016\/j.brainres.2024.148886_b0385","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1016\/S0014-5793(99)01637-3","article-title":"Structure of acetylcholinesterase complexed with (\u2212)-galanthamine at 2.3 \u00c5 resolution","volume":"463","author":"Greenblatt","year":"1999","journal-title":"FEBS Lett."},{"key":"10.1016\/j.brainres.2024.148886_b0395","doi-asserted-by":"crossref","first-page":"62558","DOI":"10.3389\/fneur.2013.00167","article-title":"Tau oligomers as potential targets for Alzheimer\u2019s diagnosis and novel drugs","volume":"4","author":"Guzm\u00e1n-Martinez","year":"2013","journal-title":"Front. Neurol."},{"key":"10.1016\/j.brainres.2024.148886_b0400","doi-asserted-by":"crossref","first-page":"2735","DOI":"10.1046\/j.1460-9568.2000.00164.x","article-title":"\u03b2-Amyloid neurotoxicity is mediated by a glutamate-triggered excitotoxic cascade in rat nucleus basalis","volume":"12","author":"Harkany","year":"2000","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.brainres.2024.148886_b0405","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/0163-7258(95)02002-0","article-title":"The pharmacology of galanthamine and its analogues","volume":"68","author":"Harvey","year":"1995","journal-title":"Pharmacol. Ther."},{"key":"10.1016\/j.brainres.2024.148886_b0410","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/j.jep.2004.02.012","article-title":"Galanthamine from snowdrop\u2014the development of a modern drug against Alzheimer\u2019s disease from local caucasian knowledge","volume":"92","author":"Heinrich","year":"2004","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.brainres.2024.148886_b0415","doi-asserted-by":"crossref","unstructured":"Ali, M.U., Anwar, L., Ali, M.H., Iqubal, M.K., Iqubal, A., Baboota, S., Ali, J., 2024. Signalling Pathways Involved in Microglial Activation in Alzheimer\u2019s Disease and Potential Neuroprotective Role of Phytoconstituents. CNS & Neurological Disorders-Drug Targets (Formerly Current Drug Targets-CNS & Neurological Disorders).","DOI":"10.2174\/1871527322666221223091529"},{"key":"10.1016\/j.brainres.2024.148886_b0420","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1016\/S1474-4422(15)70016-5","article-title":"Neuroinflammation in Alzheimer's disease","volume":"14","author":"Heneka","year":"2015","journal-title":"The Lancet Neurology."},{"key":"10.1016\/j.brainres.2024.148886_b0425","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1039\/b508966m","article-title":"Acetylcholinesterase inhibitors from plants and fungi","volume":"23","author":"Houghton","year":"2006","journal-title":"Nat. Prod. Rep."},{"key":"10.1016\/j.brainres.2024.148886_b0430","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1017\/S1041610201007888","article-title":"Effects of transdermal nicotine on learning, memory, verbal fluency, concentration, and general health in a healthy sample at risk for dementia","volume":"13","author":"Howe","year":"2001","journal-title":"Int. Psychogeriatr."},{"key":"10.1016\/j.brainres.2024.148886_b0435","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1007\/s10571-014-0028-y","article-title":"Methanolic extract of Piper nigrum fruits improves memory impairment by decreasing brain oxidative stress in amyloid beta (1\u201342) rat model of Alzheimer\u2019s disease","volume":"34","author":"Hritcu","year":"2014","journal-title":"Cell. Mol. Neurobiol."},{"key":"10.1016\/j.brainres.2024.148886_b0440","doi-asserted-by":"crossref","first-page":"64","DOI":"10.3390\/ph10030064","article-title":"Transient receptor potential (TRP) channels in drug discovery: old concepts & new thoughts","volume":"10","author":"Huang","year":"2017","journal-title":"Pharmaceuticals."},{"key":"10.1016\/j.brainres.2024.148886_b0445","doi-asserted-by":"crossref","first-page":"341","DOI":"10.7150\/ijbs.23247","article-title":"Role of plant derived alkaloids and their mechanism in neurodegenerative disorders","volume":"14","author":"Hussain","year":"2018","journal-title":"Int. J. Biol. Sci."},{"key":"10.1016\/j.brainres.2024.148886_b0450","doi-asserted-by":"crossref","first-page":"1174","DOI":"10.1001\/jamaneurol.2019.1971","article-title":"Prevalence of biologically vs clinically defined Alzheimer spectrum entities using the National Institute on Aging\u2013Alzheimer\u2019s association research framework","volume":"76","author":"Jack","year":"2019","journal-title":"JAMA Neurol."},{"key":"10.1016\/j.brainres.2024.148886_b0455","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1016\/j.phytol.2023.01.004","article-title":"Synthesis of piperine analogues as AChE and BChE inhibitors for the treatment of Alzheimer's disease","volume":"53","author":"Jaipea","year":"2023","journal-title":"Phytochem. Lett."},{"key":"10.1016\/j.brainres.2024.148886_b0460","doi-asserted-by":"crossref","first-page":"91","DOI":"10.3233\/JAD-121837","article-title":"Capsaicin ameliorates stress-induced Alzheimer's disease-like pathological and cognitive impairments in rats","volume":"35","author":"Jiang","year":"2013","journal-title":"Journal of Alzheimer's Disease."},{"key":"10.1016\/j.brainres.2024.148886_b0465","doi-asserted-by":"crossref","DOI":"10.1016\/j.neuropharm.2020.108354","article-title":"9R, the cholinesterase and amyloid beta aggregation dual inhibitor, as a multifunctional agent to improve cognitive deficit and neuropathology in the triple-transgenic Alzheimer's disease mouse model","volume":"181","author":"Ju","year":"2020","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.brainres.2024.148886_b0470","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.neuron.2014.05.041","article-title":"Alzheimer\u2019s disease genetics: from the bench to the clinic","volume":"83","author":"Karch","year":"2014","journal-title":"Neuron"},{"key":"10.1016\/j.brainres.2024.148886_b0475","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1016\/S0301-0082(97)00028-2","article-title":"The cholinergic system in Alzheimer's disease","volume":"52","author":"K\u00e1sa","year":"1997","journal-title":"Prog. Neurobiol."},{"key":"10.1016\/j.brainres.2024.148886_b0480","doi-asserted-by":"crossref","first-page":"976","DOI":"10.1016\/j.bbrc.2004.10.132","article-title":"Galantamine modulates nicotinic receptor and blocks a\u03b2-enhanced glutamate toxicity","volume":"325","author":"Kihara","year":"2004","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.brainres.2024.148886_b0485","doi-asserted-by":"crossref","unstructured":"Kim, Y.-S., Kwak, S.M., Myung, S.-K., 2015. Caffeine intake from coffee or tea and cognitive disorders: a meta-analysis of observational studies. Vol. 44, ed.^eds. S. Karger AG Basel, Switzerland, pp. 51-63.","DOI":"10.1159\/000371710"},{"key":"10.1016\/j.brainres.2024.148886_b0490","doi-asserted-by":"crossref","first-page":"1957","DOI":"10.1017\/S1461145714000613","article-title":"Galantamine promotes adult hippocampal neurogenesis via M1 muscarinic and \u03b1 7 nicotinic receptors in mice","volume":"17","author":"Kita","year":"2014","journal-title":"Int. J. Neuropsychopharmacol."},{"key":"10.1016\/j.brainres.2024.148886_b0495","first-page":"51","article-title":"Anticholinesterase activity of essential oils and their constituents from thai medicinal plants in human neuroblastoma SK-N-SH cells","volume":"1","author":"Kitphati","year":"2012","journal-title":"Journal of Asian Association of Schools of Pharmacy."},{"key":"10.1016\/j.brainres.2024.148886_b0500","doi-asserted-by":"crossref","DOI":"10.1016\/j.bioorg.2020.104567","article-title":"Alkaloids of Zephyranthes citrina (Amaryllidaceae) and their implication to Alzheimer's disease: isolation, structural elucidation and biological activity","volume":"107","author":"Kohelov\u00e1","year":"2021","journal-title":"Bioorg. Chem."},{"key":"10.1016\/j.brainres.2024.148886_b0505","doi-asserted-by":"crossref","first-page":"1701","DOI":"10.1111\/jphp.12090","article-title":"Alkaloids as a source of potential anticholinesterase inhibitors for the treatment of Alzheimer's disease","volume":"65","author":"Konrath","year":"2013","journal-title":"J. Pharm. Pharmacol."},{"key":"10.1016\/j.brainres.2024.148886_b0510","doi-asserted-by":"crossref","first-page":"7803","DOI":"10.1016\/j.bmc.2007.08.043","article-title":"Cryptadines a and B, novel C27N3-type pentacyclic alkaloids from Lycopodium cryptomerinum","volume":"15","author":"Koyama","year":"2007","journal-title":"Bioorg. Med. Chem."},{"key":"10.1016\/j.brainres.2024.148886_b0515","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1038\/nrneurol.2012.236","article-title":"Deciphering the mechanism underlying late-onset Alzheimer disease","volume":"9","author":"Krstic","year":"2013","journal-title":"Nat. Rev. Neurol."},{"key":"10.1016\/j.brainres.2024.148886_b0520","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/j.pharep.2014.09.004","article-title":"A review on Alzheimer's disease pathophysiology and its management: an update","volume":"67","author":"Kumar","year":"2015","journal-title":"Pharmacol. Rep."},{"key":"10.1016\/j.brainres.2024.148886_b0525","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1097\/01.wad.0000127445.00442.a1","article-title":"Disease stage in Alzheimer disease and treatment effects of rivastigmine","volume":"18","author":"Kurz","year":"2004","journal-title":"Alzheimer Dis. Assoc. Disord."},{"key":"10.1016\/j.brainres.2024.148886_b0530","doi-asserted-by":"crossref","first-page":"682","DOI":"10.1016\/j.steroids.2007.05.005","article-title":"Acetylcholinesterase-inhibiting steroidal alkaloid from the sponge corticium sp","volume":"72","author":"Langjae","year":"2007","journal-title":"Steroids"},{"key":"10.1016\/j.brainres.2024.148886_b0535","doi-asserted-by":"crossref","first-page":"2079","DOI":"10.1016\/j.neurobiolaging.2014.03.027","article-title":"Beneficial effects of caffeine in a transgenic model of Alzheimer's disease-like tau pathology","volume":"35","author":"Laurent","year":"2014","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.brainres.2024.148886_b0540","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.neuroscience.2012.12.013","article-title":"Endogenous morphine and its metabolites in mammals: history, synthesis, localization and perspectives","volume":"233","author":"Laux-Biehlmann","year":"2013","journal-title":"Neuroscience"},{"key":"10.1016\/j.brainres.2024.148886_b0545","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1023\/A:1022419712453","article-title":"The cognitive psychopharmacology of Alzheimer's disease: focus on cholinergic systems","volume":"23","author":"Lawrence","year":"1998","journal-title":"Neurochem. Res."},{"key":"10.1016\/j.brainres.2024.148886_b0550","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1074\/jbc.M002466200","article-title":"Indirubins inhibit glycogen synthase kinase-3\u03b2 and CDK5\/P25, two protein kinases involved in abnormal tau phosphorylation in Alzheimer's disease: a PROPERTY COMMON TO MOST CYCLIN-DEPENDENT KINASE iNHIBITORS?* 210","volume":"276","author":"Leclerc","year":"2001","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.brainres.2024.148886_b0555","doi-asserted-by":"crossref","first-page":"681","DOI":"10.3390\/molecules23030681","article-title":"Transdermal and topical drug administration in the treatment of pain","volume":"23","author":"Leppert","year":"2018","journal-title":"Molecules"},{"key":"10.1016\/j.brainres.2024.148886_b0560","doi-asserted-by":"crossref","first-page":"1572","DOI":"10.1016\/j.ejmech.2011.02.005","article-title":"Syntheses and characterization of novel oxoisoaporphine derivatives as dual inhibitors for cholinesterases and amyloid beta aggregation","volume":"46","author":"Li","year":"2011","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.brainres.2024.148886_b0565","doi-asserted-by":"crossref","DOI":"10.1002\/14651858.CD005592.pub2","article-title":"Huperzine a for Alzheimer's disease","author":"Li","year":"2008","journal-title":"Cochrane Database Syst. Rev."},{"key":"10.1016\/j.brainres.2024.148886_b0570","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.neulet.2003.12.071","article-title":"Comparative effects of huperzine a, donepezil and rivastigmine on cortical acetylcholine level and acetylcholinesterase activity in rats","volume":"361","author":"Liang","year":"2004","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.brainres.2024.148886_b0575","doi-asserted-by":"crossref","first-page":"49523","DOI":"10.1074\/jbc.M402034200","article-title":"Tumor necrosis factor-\u03b1, interleukin-1\u03b2, and interferon-\u03b3 stimulate \u03b3-secretase-mediated cleavage of amyloid precursor protein through a JNK-dependent MAPK pathway","volume":"279","author":"Liao","year":"2004","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.brainres.2024.148886_b0580","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1111\/j.1527-3458.2002.tb00221.x","article-title":"Galantamine\u2014a novel cholinergic drug with a unique dual mode of action for the treatment of patients with Alzheimer's disease","volume":"8","author":"Lilienfeld","year":"2002","journal-title":"CNS Drug Rev."},{"key":"10.1016\/j.brainres.2024.148886_b0585","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1016\/B978-0-444-64183-0.00008-7","article-title":"Alkaloids as potential multi-target drugs to treat Alzheimer's disease","volume":"61","author":"Lima","year":"2019","journal-title":"Stud. Nat. Prod. Chem."},{"key":"10.1016\/j.brainres.2024.148886_b0590","doi-asserted-by":"crossref","DOI":"10.1016\/j.bioorg.2020.104215","article-title":"Geissoschizoline, a promising alkaloid for Alzheimer\u2019s disease: inhibition of human cholinesterases, anti-inflammatory effects and molecular docking","volume":"104","author":"Lima","year":"2020","journal-title":"Bioorg. Chem."},{"key":"10.1016\/j.brainres.2024.148886_b0595","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejmech.2021.113554","article-title":"Design, synthesis and biological evaluation of harmine derivatives as potent GSK-3\u03b2\/DYRK1A dual inhibitors for the treatment of Alzheimer's disease","volume":"222","author":"Liu","year":"2021","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.brainres.2024.148886_b0600","doi-asserted-by":"crossref","first-page":"e93974","DOI":"10.1371\/journal.pone.0093974","article-title":"Berberine attenuates axonal transport impairment and axonopathy induced by calyculin a in N2a cells","volume":"9","author":"Liu","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.brainres.2024.148886_b0605","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1139\/v86-137","article-title":"The structures of huperzine a and B, two new alkaloids exhibiting marked anticholinesterase activity","volume":"64","author":"Liu","year":"1986","journal-title":"Can. J. Chem."},{"key":"10.1016\/j.brainres.2024.148886_b0610","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1016\/j.freeradbiomed.2015.02.028","article-title":"Molecular mechanisms linking amyloid \u03b2 toxicity and tau hyperphosphorylation in Alzheimer\u05f3 s disease","volume":"83","author":"Lloret","year":"2015","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.brainres.2024.148886_b0615","doi-asserted-by":"crossref","first-page":"2521","DOI":"10.1016\/S0024-3205(02)02034-9","article-title":"Acetylcholinesterase inhibitory activity of some Amaryllidaceae alkaloids and Narcissus extracts","volume":"71","author":"L\u00f3pez","year":"2002","journal-title":"Life Sci."},{"key":"10.1016\/j.brainres.2024.148886_b0620","doi-asserted-by":"crossref","first-page":"752","DOI":"10.1039\/b409720n","volume":"21","author":"Ma","year":"2004","journal-title":"The Lycopodium Alkaloids. Natural Product Reports."},{"key":"10.1016\/j.brainres.2024.148886_b0625","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1046\/j.1468-1331.2002.00421.x","article-title":"Does caffeine intake protect from Alzheimer's disease?","volume":"9","author":"Maia","year":"2002","journal-title":"Eur. J. Neurol."},{"key":"10.1016\/j.brainres.2024.148886_b0630","first-page":"451","article-title":"Prevention of Alzheimer\u2019s disease: intervention studies. understanding Alzheimer\u2019s disease; zerr, I., ed.; IntechOpen: London","volume":"17","author":"Mangialasche","year":"2013","journal-title":"UK"},{"key":"10.1016\/j.brainres.2024.148886_b0635","doi-asserted-by":"crossref","first-page":"1279","DOI":"10.3390\/molecules26051279","article-title":"Structure elucidation and cholinesterase inhibition activity of two new minor Amaryllidaceae alkaloids","volume":"26","author":"Ma\u0159\u00edkov\u00e1","year":"2021","journal-title":"Molecules"},{"key":"10.1016\/j.brainres.2024.148886_b0640","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1038\/sj.npp.1301118","article-title":"N-arachidonoyl-dopamine tunes synaptic transmission onto dopaminergic neurons by activating both cannabinoid and vanilloid receptors","volume":"32","author":"Marinelli","year":"2007","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.brainres.2024.148886_b0645","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/j.fitote.2016.09.002","article-title":"Brazilian Tabernaemontana genus: indole alkaloids and phytochemical activities","volume":"114","author":"Marinho","year":"2016","journal-title":"Fitoterapia"},{"key":"10.1016\/j.brainres.2024.148886_b0650","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1517\/13543784.15.1.1","article-title":"Novel cholinesterase inhibitors as future effective drugs for the treatment of Alzheimer\u2019s disease","volume":"15","author":"Martinez","year":"2006","journal-title":"Expert Opin. Invest. Drugs"},{"key":"10.1016\/j.brainres.2024.148886_b0655","doi-asserted-by":"crossref","first-page":"1861","DOI":"10.1007\/s11011-017-0075-4","article-title":"Huperzine a alleviates neuroinflammation, oxidative stress and improves cognitive function after repetitive traumatic brain injury","volume":"32","author":"Mei","year":"2017","journal-title":"Metab. Brain Dis."},{"key":"10.1016\/j.brainres.2024.148886_b0660","doi-asserted-by":"crossref","first-page":"59","DOI":"10.3389\/fnint.2013.00059","article-title":"Inflammatory process in Alzheimer's disease","volume":"7","author":"Meraz-R\u00edos","year":"2013","journal-title":"Front. Integr. Neurosci."},{"key":"10.1016\/j.brainres.2024.148886_b0665","series-title":"Encyclopedia of physical sciences and technology","author":"Meyers","year":"1992"},{"key":"10.1016\/j.brainres.2024.148886_b0670","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1016\/j.jalz.2014.06.015","article-title":"APOE \u03b54: the most prevalent yet understudied risk factor for Alzheimer's disease","volume":"10","author":"Michaelson","year":"2014","journal-title":"Alzheimers Dement."},{"key":"10.1016\/j.brainres.2024.148886_b0675","doi-asserted-by":"crossref","unstructured":"Millington, C., Sonego, S., Karunaweera, N., Rangel, A., Aldrich-Wright, J.R., Campbell, I.L., Gyengesi, E., M\u00fcnch, G., 2014. Chronic neuroinflammation in Alzheimer\u2019s disease: new perspectives on animal models and promising candidate drugs. BioMed research international. 2014.","DOI":"10.1155\/2014\/309129"},{"key":"10.1016\/j.brainres.2024.148886_b0680","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/j.bbrc.2014.07.098","article-title":"Genomic aspects of sporadic neurodegenerative diseases","volume":"452","author":"Mitsui","year":"2014","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.brainres.2024.148886_b0685","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1016\/j.ejmech.2016.02.049","article-title":"Amyloid cascade in Alzheimer's disease: recent advances in medicinal chemistry","volume":"113","author":"Mohamed","year":"2016","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.brainres.2024.148886_b0690","doi-asserted-by":"crossref","first-page":"112","DOI":"10.3389\/fncel.2014.00112","article-title":"Neuroinflammation in the pathogenesis of Alzheimer\u2019s disease. a rational framework for the search of novel therapeutic approaches","volume":"8","author":"Morales","year":"2014","journal-title":"Front. Cell. Neurosci."},{"key":"10.1016\/j.brainres.2024.148886_b0695","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1016\/j.phymed.2007.02.002","article-title":"Acetylcholinesterase inhibitors from plants","volume":"14","author":"Mukherjee","year":"2007","journal-title":"Phytomedicine"},{"key":"10.1016\/j.brainres.2024.148886_b0700","doi-asserted-by":"crossref","first-page":"2433","DOI":"10.2174\/092986708785909067","article-title":"Acetylcholinesterase inhibitors as disease-modifying therapies for Alzheimer's disease","volume":"15","author":"Mu\u00f1oz-Torrero","year":"2008","journal-title":"Curr. Med. Chem."},{"key":"10.1016\/j.brainres.2024.148886_b0710","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1016\/j.neuint.2015.07.018","article-title":"Plant alkaloids as drug leads for Alzheimer's disease","volume":"89","author":"Ng","year":"2015","journal-title":"Neurochem. Int."},{"key":"10.1016\/j.brainres.2024.148886_b0715","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/j.sajb.2020.03.017","article-title":"Molecular approach to promising cholinesterase inhibitory effect of several Amaryllidaceae alkaloids: further re-investigation","volume":"136","author":"Orhan","year":"2021","journal-title":"S. Afr. J. Bot."},{"key":"10.1016\/j.brainres.2024.148886_b0720","doi-asserted-by":"crossref","first-page":"698","DOI":"10.1016\/j.phymed.2009.10.003","article-title":"Effect of isoquinoline alkaloids from two Hippeastrum species on in vitro acetylcholinesterase activity","volume":"17","author":"Pagliosa","year":"2010","journal-title":"Phytomedicine"},{"key":"10.1016\/j.brainres.2024.148886_b0725","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1016\/j.neuint.2009.01.012","article-title":"Capsaicin promotes the amyloidogenic route of brain amyloid precursor protein processing","volume":"54","author":"P\u00e1k\u00e1ski","year":"2009","journal-title":"Neurochem. Int."},{"key":"10.1016\/j.brainres.2024.148886_b0730","doi-asserted-by":"crossref","unstructured":"Pan, S.-Y., Litscher, G., Gao, S.-H., Zhou, S.-F., Yu, Z.-L., Chen, H.-Q., Zhang, S.-F., Tang, M.-K., Sun, J.-N., Ko, K.-M., 2014. Historical perspective of traditional indigenous medical practices: the current renaissance and conservation of herbal resources. Evidence-based complementary and alternative medicine. 2014.","DOI":"10.1155\/2014\/525340"},{"key":"10.1016\/j.brainres.2024.148886_b0735","doi-asserted-by":"crossref","first-page":"146","DOI":"10.5114\/aoms.2013.33354","article-title":"Experimental research effects of berberine on \u03b2-secretase activity in a rabbit model of Alzheimer\u2019s disease","volume":"9","author":"Panahi","year":"2013","journal-title":"Arch. Med. Sci."},{"key":"10.1016\/j.brainres.2024.148886_b0740","first-page":"S19","article-title":"Development of reminyl (R)(galantamine), a novel acetylcholinesterase inhibitor, for the treatment of Alzheimer's disease","volume":"1","author":"Parys","year":"1998","journal-title":"Alzheimers Reports."},{"key":"10.1016\/j.brainres.2024.148886_b0745","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.phytochem.2012.11.015","article-title":"Indole alkaloids of Psychotria as multifunctional cholinesterases and monoamine oxidases inhibitors","volume":"86","author":"Passos","year":"2013","journal-title":"Phytochemistry"},{"key":"10.1016\/j.brainres.2024.148886_b0755","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1016\/j.phymed.2009.10.008","article-title":"Pharmacological effects of Catharanthus roseus root alkaloids in acetylcholinesterase inhibition and cholinergic neurotransmission","volume":"17","author":"Pereira","year":"2010","journal-title":"Phytomedicine"},{"key":"10.1016\/j.brainres.2024.148886_b0760","doi-asserted-by":"crossref","first-page":"1212","DOI":"10.1016\/j.freeradbiomed.2010.07.007","article-title":"Caffeine protects against oxidative stress and Alzheimer's disease-like pathology in rabbit hippocampus induced by cholesterol-enriched diet","volume":"49","author":"Prasanthi","year":"2010","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.brainres.2024.148886_b0765","article-title":"Discovery of novel harmine derivatives as GSK-3\u03b2\/DYRK1A dual inhibitors for Alzheimer's disease treatment","volume":"e2300404","author":"Qiu","year":"2024","journal-title":"Arch. Pharm."},{"key":"10.1016\/j.brainres.2024.148886_b0770","doi-asserted-by":"crossref","first-page":"510","DOI":"10.1016\/j.jalz.2016.03.002","article-title":"Testing and disclosures related to amyloid imaging and Alzheimer's disease: common questions and fact sheet summary","volume":"12","author":"Rabinovici","year":"2016","journal-title":"Alzheimers Dement."},{"key":"10.1016\/j.brainres.2024.148886_b0775","doi-asserted-by":"crossref","first-page":"1389","DOI":"10.1212\/WNL.0b013e318216eb7b","article-title":"A phase II trial of huperzine a in mild to moderate Alzheimer disease","volume":"76","author":"Rafii, M., Walsh, S., Little, J., Behan, K., Reynolds, B., Ward, C., Jin, S., Thomas, R., Aisen, P., Study, A.s.D.C.","year":"2011","journal-title":"Neurology"},{"key":"10.1016\/j.brainres.2024.148886_b0780","doi-asserted-by":"crossref","first-page":"2716","DOI":"10.2174\/156802611798184409","article-title":"Hybrid-based multi-target ligands for the treatment of Alzheimer's disease","volume":"11","author":"Rampa","year":"2011","journal-title":"Curr. Top. Med. Chem."},{"key":"10.1016\/j.brainres.2024.148886_b0785","article-title":"E2020 produces both clinical global and cognitive test improvement in patients with mild to moderately severe Alzheimer's disease: results of a 30 week phase III trial. in neurology. vol. 46, ed.^eds. LITTLE BROWN CO 34 BEACON STREET","volume":"02108\u20131493","author":"Rogers","year":"1996","journal-title":"BOSTON, MA"},{"key":"10.1016\/j.brainres.2024.148886_b0790","doi-asserted-by":"crossref","first-page":"34850","DOI":"10.1074\/jbc.M707358200","article-title":"DYRK1A-mediated hyperphosphorylation of tau","volume":"282","author":"Ryoo","year":"2007","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.brainres.2024.148886_b0795","article-title":"Revised NMR data for 9-O-demethylgalanthine: an alkaloid from Zephyranthes robusta (Amaryllidaceae) and its biological activity","volume":"9","author":"\u0160afratov\u00e1","year":"2014","journal-title":"Nat. Prod. Commun."},{"key":"10.1016\/j.brainres.2024.148886_b0800","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1007\/s12272-017-1000-4","article-title":"Alkaloids from Narcissus poeticus cv. pink Parasol of various structural types and their biological activity","volume":"41","author":"\u0160afratov\u00e1","year":"2018","journal-title":"Arch. Pharm. Res."},{"key":"10.1016\/j.brainres.2024.148886_b0805","doi-asserted-by":"crossref","first-page":"13568","DOI":"10.1021\/bi9617264","article-title":"Nicotine inhibits amyloid formation by the \u03b2-peptide","volume":"35","author":"Salomon","year":"1996","journal-title":"Biochemistry"},{"key":"10.1016\/j.brainres.2024.148886_b0810","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1034\/j.1600-0404.2000.00310.x","article-title":"Galantamine is an allosterically potentiating ligand of the human \u03b14\/\u03b22 nAChR","volume":"102","author":"Samochocki","year":"2000","journal-title":"Acta Neurol. Scand."},{"key":"10.1016\/j.brainres.2024.148886_b0815","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1016\/j.phytol.2012.03.004","volume":"5","author":"Sarikaya","year":"2012","journal-title":"Alkaloids from Galanthus Rizehensis. Phytochemistry Letters."},{"key":"10.1016\/j.brainres.2024.148886_b0820","doi-asserted-by":"crossref","first-page":"5311","DOI":"10.1021\/jm070536w","article-title":"New potent acetylcholinesterase inhibitors in the tetracyclic triterpene series","volume":"50","author":"Sauva\u00eetre","year":"2007","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.brainres.2024.148886_b0825","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1016\/0197-4580(92)90092-C","article-title":"Soluble and membrane-bound forms of brain acetylcholinesterase in Alzheimer's disease","volume":"13","author":"Schegg","year":"1992","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.brainres.2024.148886_b0830","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1016\/S1474-4422(03)00502-7","article-title":"Treatment of Alzheimer's disease; current status and new perspectives","volume":"2","author":"Schelterns","year":"2003","journal-title":"The Lancet Neurology."},{"key":"10.1016\/j.brainres.2024.148886_b0835","first-page":"S64","article-title":"Clinical pharmacology of aminoacridines in Alzheimer's disease","volume":"43","author":"Schneider","year":"1993","journal-title":"Neurology"},{"key":"10.1016\/j.brainres.2024.148886_b0840","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1111\/joim.12191","article-title":"Clinical trials and late-stage drug development for a lzheimer's disease: an appraisal from 1984 to 2014","volume":"275","author":"Schneider","year":"2014","journal-title":"J. Intern. Med."},{"key":"10.1016\/j.brainres.2024.148886_b0845","first-page":"1","article-title":"Agonist responses of neuronal nicotinic acetylcholine receptors are potentiated by a novel class of allosterically acting ligands","volume":"49","author":"Schrattenholz","year":"1996","journal-title":"Mol. Pharmacol."},{"key":"10.1016\/j.brainres.2024.148886_b0850","doi-asserted-by":"crossref","first-page":"959","DOI":"10.1038\/sj.bjp.0707471","article-title":"Efficacy of small-molecule glycogen synthase kinase-3 inhibitors in the postnatal rat model of tau hyperphosphorylation","volume":"152","author":"Selenica","year":"2007","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.brainres.2024.148886_b0855","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s41983-019-0094-7","article-title":"The potential value of capsaicin in modulating cognitive functions in a rat model of streptozotocin-induced Alzheimer\u2019s disease","volume":"55","author":"Shalaby","year":"2019","journal-title":"The Egyptian Journal of Neurology, Psychiatry and Neurosurgery."},{"key":"10.1016\/j.brainres.2024.148886_b0860","first-page":"2944","article-title":"Comparison of the efficacy of four cholinesterase inhibitors in combination with memantine for the treatment of Alzheimer\u2019s disease","volume":"8","author":"Shao","year":"2015","journal-title":"Int. J. Clin. Exp. Med."},{"key":"10.1016\/j.brainres.2024.148886_b0865","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1358\/dof.1999.024.04.668318","article-title":"Cholinergic therapies in Alzheimer\u2019s disease","volume":"24","author":"Siddiqui","year":"1999","journal-title":"Drugs Future."},{"key":"10.1016\/j.brainres.2024.148886_b0870","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/j.jalz.2010.03.016","article-title":"Defining optimal treatment with cholinesterase inhibitors in Alzheimer's disease","volume":"7","author":"Small","year":"2011","journal-title":"Alzheimers Dement."},{"key":"10.1016\/j.brainres.2024.148886_b0875","first-page":"143","article-title":"Effects of morphine on spatial learning and memory in healthy rats and streptozotocin rat model of Alzheimer's disease","volume":"27","author":"Sofiabadi","year":"2020","journal-title":"Journal of Sabzevar University of Medical Sciences."},{"key":"10.1016\/j.brainres.2024.148886_b0880","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.conb.2014.02.003","article-title":"Beyond pathology: APP, brain development and Alzheimer's disease","volume":"27","author":"Soldano","year":"2014","journal-title":"Curr. Opin. Neurobiol."},{"key":"10.1016\/j.brainres.2024.148886_b0885","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1750-1326-9-51","article-title":"Models of \u03b2-amyloid induced tau-pathology: the long and \u201cfolded\u201d road to understand the mechanism","volume":"9","author":"Stancu","year":"2014","journal-title":"Mol. Neurodegener."},{"key":"10.1016\/j.brainres.2024.148886_b0890","doi-asserted-by":"crossref","first-page":"5830","DOI":"10.1016\/j.bmc.2013.07.011","article-title":"Synthesis and biological evaluation of berberine\u2013thiophenyl hybrids as multi-functional agents: inhibition of acetylcholinesterase, butyrylcholinesterase, and a\u03b2 aggregation and antioxidant activity","volume":"21","author":"Su","year":"2013","journal-title":"Bioorg. Med. Chem."},{"key":"10.1016\/j.brainres.2024.148886_b0895","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.jagp.2016.10.002","article-title":"Older brains are different: brain-behavior studies and their clinical utility","volume":"25","author":"Sultzer","year":"2017","journal-title":"Am. J. Geriatr. Psychiatry"},{"key":"10.1016\/j.brainres.2024.148886_b0900","doi-asserted-by":"crossref","first-page":"115","DOI":"10.2174\/156720511795256099","article-title":"Molecular mechanisms and therapeutic application of NSAIDs and derived compounds in Alzheimer's disease","volume":"8","author":"T Heneka","year":"2011","journal-title":"Curr. Alzheimer Res."},{"key":"10.1016\/j.brainres.2024.148886_b0905","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.ejphar.2006.08.017","article-title":"Neuroprotective effects of galanthamine and tacrine against glutamate neurotoxicity","volume":"549","author":"Takada-Takatori","year":"2006","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.brainres.2024.148886_b0910","doi-asserted-by":"crossref","first-page":"S30","DOI":"10.1212\/WNL.51.1_Suppl_1.S30","article-title":"Development of acetylcholinesterase inhibitors in the therapy of Alzheimer's disease","volume":"51","author":"Taylor","year":"1998","journal-title":"Neurology"},{"key":"10.1016\/j.brainres.2024.148886_b0915","article-title":"Pathophysiology and management of Alzheimer\u2019s disease: an overview","volume":"7","author":"Thakur","year":"2018","journal-title":"J. Anal Pharm. Res."},{"key":"10.1016\/j.brainres.2024.148886_b0920","doi-asserted-by":"crossref","first-page":"1389","DOI":"10.1212\/WNL.47.6.1389","article-title":"A multicenter double-blind study of controlled-release physostigmine for the treatment of symptoms secondary to Alzheimer's disease","volume":"47","author":"Thal","year":"1996","journal-title":"Neurology"},{"key":"10.1016\/j.brainres.2024.148886_b0925","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1007\/BF00316106","article-title":"Stereoselectivity of cholinesterase inhibition by galanthamine and tolerance in humans","volume":"39","author":"Thomsen","year":"1990","journal-title":"Eur. J. Clin. Pharmacol."},{"key":"10.1016\/j.brainres.2024.148886_b0930","doi-asserted-by":"crossref","first-page":"1089","DOI":"10.3233\/JAD-2010-090667","article-title":"Neuroinflammation in Alzheimer's disease: are NSAIDs and selective COX-2 inhibitors the next line of therapy?","volume":"21","author":"Trepanier","year":"2010","journal-title":"Journal of Alzheimer's Disease."},{"key":"10.1016\/j.brainres.2024.148886_b0935","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1750-1326-9-48","article-title":"Oligomeric a\u03b2-induced synaptic dysfunction in Alzheimer\u2019s disease","volume":"9","author":"Tu","year":"2014","journal-title":"Mol. Neurodegener."},{"key":"10.1016\/j.brainres.2024.148886_b0940","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1517\/13543776.18.4.387","article-title":"Progress in acetylcholinesterase inhibitors for Alzheimer's disease: an update","volume":"18","author":"Tumiatti","year":"2008","journal-title":"Expert Opin. Ther. Pat."},{"key":"10.1016\/j.brainres.2024.148886_b0945","doi-asserted-by":"crossref","first-page":"818","DOI":"10.1080\/14756360802399662","article-title":"A potential role of alkaloid extracts from Salsola species (chenopodiaceae) in the treatment of Alzheimer's disease","volume":"24","author":"Tundis","year":"2009","journal-title":"J. Enzyme Inhib. Med. Chem."},{"key":"10.1016\/j.brainres.2024.148886_b0950","doi-asserted-by":"crossref","first-page":"1285","DOI":"10.1111\/j.1476-5381.2011.01299.x","article-title":"Animal models in the drug discovery pipeline for Alzheimer's disease","volume":"164","author":"Van Dam","year":"2011","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.brainres.2024.148886_b0955","doi-asserted-by":"crossref","first-page":"80114","DOI":"10.1039\/C6RA20205E","article-title":"Isolation of Amaryllidaceae alkaloids from Nerine bowdenii W. Watson and their biological activities","volume":"6","author":"Van\u011b\u010dkov\u00e1","year":"2016","journal-title":"RSC Adv."},{"key":"10.1016\/j.brainres.2024.148886_b0960","doi-asserted-by":"crossref","DOI":"10.1016\/j.phytochem.2021.113017","article-title":"Monoterpene indole alkaloids from Vinca minor L. (apocynaceae): identification of new structural scaffold for treatment of Alzheimer's disease","volume":"194","author":"Vrabec","year":"2022","journal-title":"Phytochemistry"},{"key":"10.1016\/j.brainres.2024.148886_b0965","doi-asserted-by":"crossref","first-page":"4399","DOI":"10.3390\/ijms24054399","article-title":"Natural alkaloids as multi-Target compounds towards factors implicated in Alzheimer\u2019s disease","volume":"24","author":"Vrabec","year":"2023","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.brainres.2024.148886_b0970","doi-asserted-by":"crossref","first-page":"5626","DOI":"10.1074\/jbc.275.8.5626","article-title":"\u03b2-Amyloid1\u201342 binds to \u03b17 nicotinic acetylcholine receptor with high affinity: implications for Alzheimer's disease pathology","volume":"275","author":"Wang","year":"2000","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.brainres.2024.148886_b0975","first-page":"27","article-title":"Anticholinesterase effects of huperzine a, E2020, and tacrine in rats. zhongguo yao li xue bao=","volume":"19","author":"Wang","year":"1998","journal-title":"Acta Pharmacol. Sin."},{"key":"10.1016\/j.brainres.2024.148886_b0980","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1159\/000085387","article-title":"Neuroprotective effects of huperzine a: a natural cholinesterase inhibitor for the treatment of Alzheimer\u2019s disease","volume":"14","author":"Wang","year":"2005","journal-title":"Neurosignals"},{"key":"10.1016\/j.brainres.2024.148886_b0985","doi-asserted-by":"crossref","first-page":"2629","DOI":"10.1097\/00001756-200108280-00009","article-title":"Huperzine a attenuates hydrogen peroxide-induced apoptosis by regulating expression of apoptosis-related genes in rat PC12 cells","volume":"12","author":"Wang","year":"2001","journal-title":"Neuroreport"},{"key":"10.1016\/j.brainres.2024.148886_b0990","first-page":"110","article-title":"Anti-cholinesterase activity of huperzine a. zhongguo yao li xue bao=","volume":"7","author":"Wang","year":"1986","journal-title":"Acta Pharmacol. Sin."},{"key":"10.1016\/j.brainres.2024.148886_b0995","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/S0014-2999(01)01030-5","article-title":"Huperzine a attenuates cognitive dysfunction and neuronal degeneration caused by \u03b2-amyloid protein-(1\u201340) in rat","volume":"421","author":"Wang","year":"2001","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.brainres.2024.148886_b1000","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1745-7254.2006.00255.x","article-title":"Progress in studies of huperzine a, a natural cholinesterase inhibitor from chinese herbal medicine 1","volume":"27","author":"Wang","year":"2006","journal-title":"Acta Pharmacol. Sin."},{"key":"10.1016\/j.brainres.2024.148886_b1005","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1111\/bcp.12621","article-title":"Emerging drug targets for a\u03b2 and tau in Alzheimer's disease: a systematic review","volume":"80","author":"West","year":"2015","journal-title":"Br. J. Clin. Pharmacol."},{"key":"10.1016\/j.brainres.2024.148886_b1010","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1007\/s002130050931","article-title":"Four-week nicotine skin patch treatment effects on cognitive performance in Alzheimer\u2019s disease","volume":"143","author":"White","year":"1999","journal-title":"Psychopharmacology (Berl)"},{"key":"10.1016\/j.brainres.2024.148886_b1015","doi-asserted-by":"crossref","first-page":"453","DOI":"10.2165\/00002512-200421070-00004","article-title":"Cholinesterase inhibitors used in the treatment of Alzheimer\u2019s disease: the relationship between pharmacological effects and clinical efficacy","volume":"21","author":"Wilkinson","year":"2004","journal-title":"Drugs Aging"},{"key":"10.1016\/j.brainres.2024.148886_b1020","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1039\/C0NP00027B","article-title":"Natural products as a source of Alzheimer's drug leads","volume":"28","author":"Williams","year":"2011","journal-title":"Nat. Prod. Rep."},{"key":"10.1016\/j.brainres.2024.148886_b1025","doi-asserted-by":"crossref","first-page":"2089","DOI":"10.1073\/pnas.98.4.2089","article-title":"Galantamine: effect on nicotinic receptor binding, acetylcholinesterase inhibition, and learning","volume":"98","author":"Woodruff-Pak","year":"2001","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1016\/j.brainres.2024.148886_b1030","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1007\/s12035-014-8994-0","article-title":"The binding receptors of a\u03b2: an alternative therapeutic target for Alzheimer\u2019s disease","volume":"53","author":"Xia","year":"2016","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.brainres.2024.148886_b1035","doi-asserted-by":"crossref","unstructured":"Xian, Y.-F., Lin, Z.-X., Mao, Q.-Q., Hu, Z., Zhao, M., Che, C.-T., Ip, S.-P., 2012a. Bioassay-guided isolation of neuroprotective compounds from Uncaria rhynchophylla against beta-amyloid-induced neurotoxicity. Evidence-Based Complementary and Alternative Medicine. 2012.","DOI":"10.1155\/2012\/802625"},{"key":"10.1016\/j.brainres.2024.148886_b1040","doi-asserted-by":"crossref","unstructured":"Xian, Y.-F., Lin, Z.-X., Mao, Q.-Q., Chen, J.-N., Su, Z.-R., Lai, X.-P., Ip, P.S.-P., 2013. Isorhynchophylline protects PC12 cells against beta-amyloid-induced apoptosis via PI3K\/Akt signaling pathway. Evidence-based complementary and alternative medicine. 2013.","DOI":"10.1155\/2013\/163057"},{"key":"10.1016\/j.brainres.2024.148886_b1045","doi-asserted-by":"crossref","first-page":"1977","DOI":"10.1055\/s-0031-1280125","article-title":"Uncaria rhynchophylla ameliorates cognitive deficits induced by D-galactose in mice","volume":"77","author":"Xian","year":"2011","journal-title":"Planta Med."},{"key":"10.1016\/j.brainres.2024.148886_b1055","doi-asserted-by":"crossref","first-page":"331","DOI":"10.3233\/JAD-131457","article-title":"Isorhynchophylline treatment improves the amyloid-\u03b2-induced cognitive impairment in rats via inhibition of neuronal apoptosis and tau protein hyperphosphorylation","volume":"39","author":"Xian","year":"2014","journal-title":"J. Alzheimers Dis."},{"key":"10.1016\/j.brainres.2024.148886_b1060","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1002\/jnr.10075","article-title":"Huperzine a attenuates amyloid \u03b2-peptide fragment 25\u201335-induced apoptosis in rat cortical neurons via inhibiting reactive oxygen species formation and caspase-3 activation","volume":"67","author":"Xiao","year":"2002","journal-title":"J. Neurosci. Res."},{"key":"10.1016\/j.brainres.2024.148886_b1065","first-page":"486","article-title":"Huperzine-a in capsules and tablets for treating patients with Alzheimer disease. zhongguo yao li xue bao=","volume":"20","author":"Xu","year":"1999","journal-title":"Acta Pharmacol. Sin."},{"key":"10.1016\/j.brainres.2024.148886_b1070","doi-asserted-by":"crossref","first-page":"925","DOI":"10.3892\/ijmm.2014.1632","article-title":"Nicotine exerts neuroprotective effects against \u03b2-amyloid-induced neurotoxicity in SH-SY5Y cells through the Erk1\/2-p38-JNK-dependent signaling pathway","volume":"33","author":"Xue","year":"2014","journal-title":"Int. J. Mol. Med."},{"key":"10.1016\/j.brainres.2024.148886_b1075","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/S0163-7258(00)00081-4","article-title":"Animal models of Alzheimer's disease and evaluation of anti-dementia drugs","volume":"88","author":"Yamada","year":"2000","journal-title":"Pharmacol. Ther."},{"key":"10.1016\/j.brainres.2024.148886_b1080","doi-asserted-by":"crossref","first-page":"e74916","DOI":"10.1371\/journal.pone.0074916","article-title":"Huperzine a for Alzheimer\u2019s disease: a systematic review and meta-analysis of randomized clinical trials","volume":"8","author":"Yang","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.brainres.2024.148886_b1085","doi-asserted-by":"crossref","first-page":"131","DOI":"10.3233\/JAD-2012-120274","article-title":"Decreased accumulation of subcellular amyloid-\u03b2 with improved mitochondrial function mediates the neuroprotective effect of huperzine a","volume":"31","author":"Yang","year":"2012","journal-title":"J. Alzheimers Dis."},{"key":"10.1016\/j.brainres.2024.148886_b1090","doi-asserted-by":"crossref","first-page":"1336","DOI":"10.1080\/07391102.2014.947326","article-title":"Cytotoxicity and comparative binding mechanism of piperine with human serum albumin and \u03b1-1-acid glycoprotein","volume":"33","author":"Yeggoni","year":"2015","journal-title":"J. Biomol. Struct. Dyn."},{"key":"10.1016\/j.brainres.2024.148886_b1095","article-title":"Molecular forms of acetylcholinesterases in Alzheimer's disease. in","volume":"45","author":"Younkin","year":"1986","journal-title":"Fed. Proc."},{"key":"10.1016\/j.brainres.2024.148886_b1100","article-title":"2.218 Berberine Attenuates Calyculin a-Induced Cytotoxicity and Tau Hyperphosphorylation in HEK293 Cells","volume":"S119","author":"Yu","year":"2012","journal-title":"Parkinsonism Relat. Disord."},{"key":"10.1016\/j.brainres.2024.148886_b1105","doi-asserted-by":"crossref","first-page":"661","DOI":"10.17219\/acem\/121007","article-title":"The role of GLP-1\/GIP receptor agonists in Alzheimer\u2019s disease","volume":"29","author":"Yu","year":"2020","journal-title":"Adv. Clin. Exp. Med."},{"key":"10.1016\/j.brainres.2024.148886_b1110","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12906-019-2510-z","article-title":"Neuroprotective effects of berberine in animal models of Alzheimer\u2019s disease: a systematic review of pre-clinical studies","volume":"19","author":"Yuan","year":"2019","journal-title":"BMC Complement. Altern. Med."},{"key":"10.1016\/j.brainres.2024.148886_b1115","doi-asserted-by":"crossref","first-page":"e202300225","DOI":"10.1002\/slct.202300225","article-title":"Neurodegenerative diseases: their onset, epidemiology, causes and treatment","volume":"8","author":"Zaib","year":"2023","journal-title":"ChemistrySelect"},{"key":"10.1016\/j.brainres.2024.148886_b1120","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/j.brainres.2011.08.036","article-title":"Caffeine induces beneficial changes in PKA signaling and JNK and ERK activities in the striatum and cortex of Alzheimer's transgenic mice","volume":"1417","author":"Zeitlin","year":"2011","journal-title":"Brain Res."},{"key":"10.1016\/j.brainres.2024.148886_b1125","doi-asserted-by":"crossref","first-page":"3612","DOI":"10.3390\/ijms22073612","article-title":"The main alkaloids in Uncaria rhynchophylla and their anti-Alzheimer\u2019s disease mechanism determined by a network pharmacology approach","volume":"22","author":"Zeng","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.brainres.2024.148886_b1130","doi-asserted-by":"crossref","unstructured":"Zhang, C., Wu, X., Xian, Y., Zhu, L., Lin, G., Lin, Z.-X., 2019. Evidence on integrating pharmacokinetics to find truly therapeutic agent for Alzheimer\u2019s disease: comparative pharmacokinetics and disposition kinetics profiles of stereoisomers isorhynchophylline and rhynchophylline in rats. Evidence-Based Complementary and Alternative Medicine. 2019.","DOI":"10.1155\/2019\/4016323"},{"key":"10.1016\/j.brainres.2024.148886_b1135","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1016\/j.tips.2006.10.004","article-title":"Neuroprotective effects of huperzine a: new therapeutic targets for neurodegenerative disease","volume":"27","author":"Zhang","year":"2006","journal-title":"Trends Pharmacol. Sci."},{"key":"10.1016\/j.brainres.2024.148886_b1140","first-page":"941","article-title":"Clinical efficacy and safety of huperzine alpha in treatment of mild to moderate Alzheimer disease, a placebo-controlled, double-blind, randomized trial","volume":"82","author":"Zhang","year":"2002","journal-title":"Zhonghua Yi Xue Za Zhi"},{"key":"10.1016\/j.brainres.2024.148886_b1145","doi-asserted-by":"crossref","first-page":"2073","DOI":"10.1097\/00001756-200107200-00007","article-title":"Huperzine a protects rat pheochromocytoma cells against oxygen\u2013glucose deprivation","volume":"12","author":"Zhou","year":"2001","journal-title":"Neuroreport"},{"key":"10.1016\/j.brainres.2024.148886_b1150","doi-asserted-by":"crossref","first-page":"9280","DOI":"10.1073\/pnas.95.16.9280","article-title":"Conformation gating as a mechanism for enzyme specificity","volume":"95","author":"Zhou","year":"1998","journal-title":"Proc. Natl. Acad. Sci."}],"container-title":["Brain Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006899324001409?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006899324001409?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,5,8]],"date-time":"2024-05-08T01:02:57Z","timestamp":1715130177000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006899324001409"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,7]]},"references-count":225,"alternative-id":["S0006899324001409"],"URL":"https:\/\/doi.org\/10.1016\/j.brainres.2024.148886","relation":{},"ISSN":["0006-8993"],"issn-type":[{"value":"0006-8993","type":"print"}],"subject":[],"published":{"date-parts":[[2024,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Alkaloids as drug leads in Alzheimer's treatment: Mechanistic and therapeutic insights","name":"articletitle","label":"Article Title"},{"value":"Brain Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.brainres.2024.148886","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"148886"}}