{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,27]],"date-time":"2026-06-27T13:46:53Z","timestamp":1782568013285,"version":"3.54.5"},"reference-count":64,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T00:00:00Z","timestamp":1722470400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T00:00:00Z","timestamp":1722470400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T00:00:00Z","timestamp":1722470400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T00:00:00Z","timestamp":1722470400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T00:00:00Z","timestamp":1722470400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T00:00:00Z","timestamp":1722470400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T00:00:00Z","timestamp":1722470400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100008994","name":"European Society of Contraception and Reproductive Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008994","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007684","name":"Ministry of Education and Science of Ukraine","doi-asserted-by":"publisher","award":["0120U102130"],"award-info":[{"award-number":["0120U102130"]}],"id":[{"id":"10.13039\/501100007684","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Brain Research"],"published-print":{"date-parts":[[2024,8]]},"DOI":"10.1016\/j.brainres.2024.148960","type":"journal-article","created":{"date-parts":[[2024,4,26]],"date-time":"2024-04-26T12:07:25Z","timestamp":1714133245000},"page":"148960","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":6,"special_numbering":"C","title":["Systemic inflammation in A\u03b21-40-induced Alzheimer\u2019s disease model: New translational opportunities"],"prefix":"10.1016","volume":"1837","author":[{"given":"Anastasiia","family":"Nefodova","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1252-885X","authenticated-orcid":false,"given":"Mariia","family":"Rudyk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1189-4479","authenticated-orcid":false,"given":"Roman","family":"Dovhyi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taisa","family":"Dovbynchuk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nataliia","family":"Dzubenko","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5286-5044","authenticated-orcid":false,"given":"Ganna","family":"Tolstanova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Larysa","family":"Skivka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.brainres.2024.148960_b0005","doi-asserted-by":"crossref","unstructured":"2023 Alzheimer\u2019s disease facts and figures, 2023. Alzheimers Dementia. 19, 1598\u20131695. 10.1002\/alz.13016.","DOI":"10.1002\/alz.13016"},{"key":"10.1016\/j.brainres.2024.148960_b0010","doi-asserted-by":"crossref","first-page":"379","DOI":"10.3233\/ADR-200178","article-title":"The association between anemia of chronic inflammation and Alzheimer\u2019s disease and related dementias","volume":"4","author":"Andreev","year":"2020","journal-title":"J. Alzheimers Dis. Rep."},{"key":"10.1016\/j.brainres.2024.148960_b0015","doi-asserted-by":"crossref","first-page":"1123149","DOI":"10.3389\/fimmu.2023.1123149","article-title":"Neutrophils as a potential therapeutic target in Alzheimer\u2019s disease","volume":"14","author":"Aries","year":"2023","journal-title":"Front. Immunol."},{"key":"10.1016\/j.brainres.2024.148960_b0020","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1111\/anae.15896","article-title":"Postoperative systemic inflammatory dysregulation and corticosteroids: a narrative review","volume":"78","author":"Bain","year":"2023","journal-title":"Anaesthesia."},{"key":"10.1016\/j.brainres.2024.148960_b0025","doi-asserted-by":"crossref","first-page":"354","DOI":"10.15421\/022054","article-title":"The effect of miR-101 on the memory of rats with a model of Alzheimer\u2019s disease","volume":"11","author":"Berchenko","year":"2020","journal-title":"Regul. Mech. Biosyst."},{"key":"10.1016\/j.brainres.2024.148960_b0030","doi-asserted-by":"crossref","first-page":"1323","DOI":"10.3389\/fimmu.2020.01323","article-title":"Pro-inflammatory actions of heme and other hemoglobin-derived DAMPs","volume":"11","author":"Bozza","year":"2020","journal-title":"Front. Immunol."},{"key":"10.1016\/j.brainres.2024.148960_b0035","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1186\/s13024-018-0284-2","article-title":"Peripheral immune system in aging and Alzheimer's disease","volume":"13","author":"Cao","year":"2018","journal-title":"Mol. Neurodegener."},{"key":"10.1016\/j.brainres.2024.148960_b0040","doi-asserted-by":"crossref","first-page":"1755","DOI":"10.1093\/ptj\/77.12.1755","article-title":"Learning and understanding the Kruskal-Wallis One-Way Analysis-of-Variance-by-Ranks Test for differences among three or more independent groups","volume":"77","author":"Chan","year":"1997","journal-title":"Phys. Ther."},{"key":"10.1016\/j.brainres.2024.148960_b0045","doi-asserted-by":"crossref","DOI":"10.1016\/j.brainres.2023.148449","article-title":"Animal models of Alzheimer's disease: An originof innovativetreatments and insight to the disease's etiology","volume":"1814","author":"Chavan","year":"2023","journal-title":"Brain Res."},{"key":"10.1016\/j.brainres.2024.148960_b0050","doi-asserted-by":"crossref","first-page":"e6843","DOI":"10.1097\/MD.0000000000006843","article-title":"Altered peripheral profile of blood cells in Alzheimer disease: A hospital-based case-control study","volume":"96","author":"Chen","year":"2017","journal-title":"Medicine (Baltimore)."},{"key":"10.1016\/j.brainres.2024.148960_b0055","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1186\/s12974-016-0483-0","article-title":"Myeloid dendritic cells are decreased in peripheral blood of Alzheimer\u2019s disease patients in association with disease progression and severity of depressive symptoms","volume":"13","author":"Ciaramella","year":"2016","journal-title":"J. Neuroinflammation."},{"key":"10.1016\/j.brainres.2024.148960_b0060","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1016\/j.mcna.2016.09.005","article-title":"Anemia of inflammation","volume":"101","author":"Fraenkel","year":"2017","journal-title":"Med. Clin. North Am."},{"key":"10.1016\/j.brainres.2024.148960_b0065","first-page":"e105","article-title":"Dementia Forecasting Collaborators, 2022. Estimation of the global prevalence of dementia in 2019 and forecasted prevalence in 2050: an analysis for the Global Burden of Disease Study 2019","volume":"7","author":"GBD 2019 Dementia Forecasting Collaborators","year":"2019","journal-title":"Lancet Public Health"},{"key":"10.1016\/j.brainres.2024.148960_b0070","doi-asserted-by":"crossref","first-page":"2090","DOI":"10.1007\/s11064-022-03603-2","article-title":"Therapeutic effects of high-intensity interval training exercise alone and its combination with ecdysterone against amyloid beta-induced rat model of Alzheimer\u2019s disease: A behavioral, biochemical, and histological study","volume":"47","author":"Gholipour","year":"2022","journal-title":"Neurochem. Res."},{"key":"10.1016\/j.brainres.2024.148960_b0075","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1007\/s12031-018-1189-9","article-title":"Intracerebroventricular A\u0392-Induced neuroinflammation alters peripheral immune responses in rats","volume":"66","author":"Gupta","year":"2018","journal-title":"J. Mol. Neurosci."},{"key":"10.1016\/j.brainres.2024.148960_b0080","article-title":"The interplay between beta-amyloid 1\u201342 (A\u03b21-42)-induced hippocampal inflammatory response, p-tau, vascular pathology, and their synergistic contributions to neuronal death and behavioral deficits","volume":"13","author":"Guzm\u00e1n","year":"2020","journal-title":"Front. Mol. Neurosci."},{"key":"10.1016\/j.brainres.2024.148960_b0085","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1038\/s41423-021-00832-3","article-title":"Neutrophils in chronic inflammatory diseases","volume":"19","author":"Herrero-Cervera","year":"2022","journal-title":"Cell. Mol. Immunol."},{"key":"10.1016\/j.brainres.2024.148960_b0090","doi-asserted-by":"crossref","first-page":"6212","DOI":"10.1158\/1078-0432.CCR-14-0442","article-title":"Systemic immune-inflammation index predicts prognosis of patients after curative resection for hepatocellular carcinoma","volume":"20","author":"Hu","year":"2014","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.brainres.2024.148960_b0095","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1016\/j.neuropharm.2017.12.030","article-title":"The pathology and pathophysiology of vascular dementia","volume":"134","author":"Kalaria","year":"2018","journal-title":"Neuropharmacology."},{"key":"10.1016\/j.brainres.2024.148960_b0100","doi-asserted-by":"crossref","first-page":"25","DOI":"10.3389\/fnins.2018.00025","article-title":"Reconsideration of amyloid hypothesis and Tau hypothesis in Alzheimer\u2019s disease","volume":"12","author":"Kametani","year":"2018","journal-title":"Front. Neurosci."},{"key":"10.1016\/j.brainres.2024.148960_b0105","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1177\/1533317513488914","article-title":"Spontaneous and Induced nontransgenic animal models of AD","volume":"28","author":"Kaushal","year":"2013","journal-title":"Am. J. Alzheimers. Dis. Other Demen."},{"key":"10.1016\/j.brainres.2024.148960_b0110","doi-asserted-by":"crossref","first-page":"1169560","DOI":"10.3389\/fimmu.2023.1169560","article-title":"Damage-mediated macrophage polarization in sterile inflammation","volume":"14","author":"Koncz","year":"2023","journal-title":"Front. Immunol."},{"key":"10.1016\/j.brainres.2024.148960_b0115","doi-asserted-by":"crossref","first-page":"2131","DOI":"10.4103\/1673-5374.335836","article-title":"Unraveling pathological mechanisms in neurological disorders: the impact of cell-based and organoid models","volume":"17","author":"Langlie","year":"2022","journal-title":"Neural Regen. Res."},{"key":"10.1016\/j.brainres.2024.148960_b0120","doi-asserted-by":"crossref","DOI":"10.1016\/j.mad.2021.111462","article-title":"Amyloid-\u03b21-40 differentially stimulates proliferation, activation of oxidative stress and inflammatory responses in male and female hippocampal astrocyte cultures","volume":"195","author":"Lennol","year":"2021","journal-title":"Mech. Ageing Dev."},{"key":"10.1016\/j.brainres.2024.148960_b0125","doi-asserted-by":"crossref","first-page":"1069439","DOI":"10.3389\/fnagi.2023.1069439","article-title":"Association of inflammation and cognition in the elderly: A systematic review and meta-analysis","volume":"15","author":"Leonardo","year":"2023","journal-title":"Front. Aging Neurosci."},{"key":"10.1016\/j.brainres.2024.148960_b0130","doi-asserted-by":"crossref","first-page":"e12517","DOI":"10.1002\/dad2.12517","article-title":"Exploring the links among peripheral immunity, biomarkers, cognition, and neuroimaging in Alzheimer's disease","volume":"15","author":"Li","year":"2023","journal-title":"Alzheimers Dement (Amst)."},{"key":"10.1016\/j.brainres.2024.148960_b0135","doi-asserted-by":"crossref","first-page":"e479","DOI":"10.1016\/S2666-7568(21)00140-9","article-title":"Mortality rates in Alzheimer\u2019s disease and non-Alzheimer\u2019s dementias: a systematic review and meta-analysis","volume":"2","author":"Liang","year":"2021","journal-title":"Lancet Healthy Longev."},{"key":"10.1016\/j.brainres.2024.148960_b0140","doi-asserted-by":"crossref","first-page":"2785","DOI":"10.1007\/s11357-021-00474-3","article-title":"Leukocyte-derived ratios are associated with late-life any type dementia: a cross-sectional analysis of the Mugello study","volume":"43","author":"Lombardi","year":"2021","journal-title":"Geroscience"},{"key":"10.1016\/j.brainres.2024.148960_b0145","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2022.113168","article-title":"Overview of therapeutic targets in management of dementia","volume":"152","author":"Malik","year":"2022","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.brainres.2024.148960_b0150","doi-asserted-by":"crossref","DOI":"10.1016\/j.conb.2022.102575","article-title":"How neurons die in Alzheimer\u2019s disease: Implications for neuroinflammation","volume":"75","author":"Mangalmurti","year":"2022","journal-title":"Curr. Opin. Neurobiol."},{"key":"10.1016\/j.brainres.2024.148960_b0155","doi-asserted-by":"crossref","first-page":"475","DOI":"10.2174\/156720508785908874","article-title":"Relevance of abeta1-42 intrahippocampal injection as an animal model of inflamed Alzheimer's disease brain","volume":"5","author":"McLarnon","year":"2008","journal-title":"Curr. Alzheimer Res."},{"key":"10.1016\/j.brainres.2024.148960_b0160","doi-asserted-by":"crossref","first-page":"67","DOI":"10.4103\/aca.ACA_157_18","article-title":"Descriptive statistics and normality tests for statistical data","volume":"22","author":"Mishra","year":"2019","journal-title":"Ann. Cardiac Anaesth."},{"key":"10.1016\/j.brainres.2024.148960_b0165","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1186\/s12979-021-00236-x","article-title":"Hyperactivation of monocytes and macrophages in MCI patients contributes to the progression of Alzheimer\u2019s disease","volume":"18","author":"Munawara","year":"2021","journal-title":"Immun. Ageing."},{"key":"10.1016\/j.brainres.2024.148960_b0170","first-page":"56","article-title":"Pro-inflammatory effects of placebo neurosurgery in rats: age-related features","volume":"2","author":"Nefodova","year":"2022","journal-title":"Gen. Surg. (Ukraine)"},{"key":"10.1016\/j.brainres.2024.148960_b0175","doi-asserted-by":"crossref","first-page":"57","DOI":"10.15407\/biotech16.01.057","article-title":"Microglia phagocytic activity in rats with different models of Alzheimer\u2019s disease","volume":"16","author":"Nefodova","year":"2023","journal-title":"Biotechnol. Acta."},{"key":"10.1016\/j.brainres.2024.148960_b0180","doi-asserted-by":"crossref","DOI":"10.1016\/j.pharmthera.2022.108119","article-title":"Blood-brain barrier leakage in Alzheimer\u2019s disease: From discovery to clinical relevance","volume":"234","author":"Nehra","year":"2022","journal-title":"Pharmacol. Ther."},{"key":"10.1016\/j.brainres.2024.148960_b0185","article-title":"Inflammatory hallmarks in 6-OHDA- and LPS-induced Parkinson\u2019s disease in rats","volume":"30","author":"Oliynyk","year":"2023","journal-title":"Brain Behav. Immun. Health."},{"key":"10.1016\/j.brainres.2024.148960_b0190","doi-asserted-by":"crossref","first-page":"559","DOI":"10.2174\/1567205016666190321154618","article-title":"Systemic and CNS inflammation crosstalk: Implications for Alzheimer\u2019s disease","volume":"16","author":"Paouri","year":"2019","journal-title":"Curr. Alzheimer Res."},{"key":"10.1016\/j.brainres.2024.148960_b0195","doi-asserted-by":"crossref","DOI":"10.1016\/j.pnpbp.2022.110668","article-title":"The relationship between inflammatory biomarkers and cognitive dysfunction in patients with schizophrenia: A systematic review and meta-analysis","volume":"121","author":"Patlola","year":"2023","journal-title":"Prog. Neuropsychopharmacol. Biol. Psychiatry."},{"key":"10.1016\/j.brainres.2024.148960_b0200","article-title":"Barnes maze test for spatial memory: A new, sensitive scoring system for mouse search strategies","volume":"458","author":"Peris","year":"2024","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.brainres.2024.148960_b0205","doi-asserted-by":"crossref","unstructured":"Poon, C.H., Wang, Y., Fung, M., Zhang, C., Lim, L.W., 2020. Rodent models of Amyloid-Beta feature of Alzheimer\u2019s disease: development and potential treatment implications. Aging. Dis. 11, 1235-1259. 10.14336\/ad.2019.1026.","DOI":"10.14336\/AD.2019.1026"},{"key":"10.1016\/j.brainres.2024.148960_b0210","doi-asserted-by":"crossref","DOI":"10.1016\/j.mex.2022.101933","article-title":"Experimentally induced animal models for cognitive dysfunction and Alzheimer\u2019s disease","volume":"9","author":"Rapaka","year":"2022","journal-title":"MethodsX"},{"key":"10.1016\/j.brainres.2024.148960_b0215","doi-asserted-by":"crossref","DOI":"10.1155\/2015\/816460","article-title":"Understanding the mysterious M2 macrophage through activation markers and effector mechanisms","volume":"2015","author":"R\u0151szer","year":"2015","journal-title":"Mediators Inflamm."},{"key":"10.1016\/j.brainres.2024.148960_b0220","doi-asserted-by":"crossref","first-page":"2944","DOI":"10.1021\/acschemneuro.3c00486","article-title":"Oxidative stress occurs prior to amyloid A\u03b2 plaque formation and tau phosphorylation in Alzheimer's disease: role of glutathione and metal ions","volume":"14","author":"Roy","year":"2023","journal-title":"ACS Chem. Neurosci."},{"key":"10.1016\/j.brainres.2024.148960_b0225","doi-asserted-by":"crossref","DOI":"10.1016\/j.jneuroim.2020.577398","article-title":"The neutrophil-to-lymphocyte ratio in Alzheimer\u2019s disease: Current understanding and potential applications","volume":"349","author":"Sayed","year":"2020","journal-title":"J. Neuroimmunol."},{"key":"10.1016\/j.brainres.2024.148960_b0230","doi-asserted-by":"crossref","first-page":"834","DOI":"10.1212\/CON.0000000000001137","article-title":"Neuropathology of dementia disorders","volume":"28","author":"Schneider","year":"2022","journal-title":"Continuum (Minneap Minn)."},{"key":"10.1016\/j.brainres.2024.148960_b0235","doi-asserted-by":"crossref","first-page":"e94","DOI":"10.1016\/S2468-2667(21)00277-2","article-title":"Forecasting the prevalence of dementia","volume":"7","author":"Schwarzinger","year":"2022","journal-title":"The Lancet Public Health."},{"key":"10.1016\/j.brainres.2024.148960_b0240","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/j.neulet.2011.06.009","article-title":"Rat hippocampal proteomic alterations following intrahippocampal injection of amyloid beta peptide (1\u201340)","volume":"500","author":"Shi","year":"2011","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.brainres.2024.148960_b0245","doi-asserted-by":"crossref","first-page":"708","DOI":"10.4103\/1673-5374.353484","article-title":"Targeting neuroinflammation in Alzheimer's disease: from mechanisms to clinical applications","volume":"18","author":"Si","year":"2023","journal-title":"Neural Regen. Res."},{"key":"10.1016\/j.brainres.2024.148960_b0250","doi-asserted-by":"crossref","first-page":"5481","DOI":"10.3390\/molecules27175481","article-title":"Lipopolysaccharide-induced model of neuroinflammation: mechanisms of action, research application and future directions for its use","volume":"27","author":"Skrzypczak-Wiercioch","year":"2022","journal-title":"Molecules"},{"key":"10.1016\/j.brainres.2024.148960_b0255","doi-asserted-by":"crossref","first-page":"e12114","DOI":"10.1002\/trc2.12114","article-title":"Translational animal models for Alzheimer\u2019s disease: An Alzheimer\u2019s Association Business Consortium Think Tank","volume":"6","author":"Vitek","year":"2020","journal-title":"Alzheimers Dement (N Y)."},{"key":"10.1016\/j.brainres.2024.148960_b0260","doi-asserted-by":"crossref","first-page":"2606","DOI":"10.4103\/1673-5374.336138","article-title":"From cradle to grave: neurogenesis, neuroregeneration and neurodegeneration in Alzheimer\u2019s and Parkinson\u2019s diseases","volume":"17","author":"Wakhloo","year":"2022","journal-title":"Neural Regen. Res."},{"key":"10.1016\/j.brainres.2024.148960_b0265","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1186\/s13024-023-00627-2","article-title":"The role of peripheral inflammatory insults in Alzheimer\u2019s disease: a review and research roadmap","volume":"18","author":"Walker","year":"2023","journal-title":"Mol. Neurodegener."},{"key":"10.1016\/j.brainres.2024.148960_b0270","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1016\/j.neuroscience.2010.12.005","article-title":"Time-course of nigrostriatal neurodegeneration and neuroinflammation in the 6-hydroxydopamine-induced axonal and terminal lesion models of Parkinson's disease in the rat","volume":"175","author":"Walsh","year":"2011","journal-title":"Neuroscience"},{"key":"10.1016\/j.brainres.2024.148960_b0275","doi-asserted-by":"crossref","first-page":"1375","DOI":"10.1159\/000522500","article-title":"Association of anemia with dementia and cognitive decline among community-dwelling elderly","volume":"68","author":"Weiss","year":"2022","journal-title":"Gerontology."},{"key":"10.1016\/j.brainres.2024.148960_b0280","doi-asserted-by":"crossref","first-page":"e917","DOI":"10.1212\/WNL.0000000000008003","article-title":"Hemoglobin and anemia in relation to dementia risk and accompanying changes on brain MRI","volume":"93","author":"Wolters","year":"2019","journal-title":"Neurology."},{"key":"10.1016\/j.brainres.2024.148960_b0285","doi-asserted-by":"crossref","first-page":"1618","DOI":"10.1093\/rheumatology\/keq045","article-title":"Neutrophil function in inflammation and inflammatory diseases","volume":"49","author":"Wright","year":"2010","journal-title":"Rheumatology (Oxford)."},{"key":"10.1016\/j.brainres.2024.148960_b0290","doi-asserted-by":"crossref","first-page":"2290","DOI":"10.1007\/s12035-020-01885-7","article-title":"Amyloid fibril-induced astrocytic glutamate transporter disruption contributes to complement C1q-mediated microglial pruning of glutamatergic synapses","volume":"57","author":"Wu","year":"2020","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.brainres.2024.148960_b0295","first-page":"192","article-title":"Animal models of Alzheimer\u2019s disease: preclinical insights and challenges","volume":"2","author":"Xu","year":"2023","journal-title":"Acta Mater. Med."},{"key":"10.1016\/j.brainres.2024.148960_b0300","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/j.archger.2009.09.035","article-title":"Life expectancy in Alzheimer's disease (AD)","volume":"49","author":"Zanetti","year":"2009","journal-title":"Arch. Gerontol. Geriatr."},{"key":"10.1016\/j.brainres.2024.148960_b0305","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1007\/s12031-017-0966-1","article-title":"IRF-8 is involved in amyloid-\u03b21\u201340 (A\u03b21\u201340)-induced microglial activation: a new implication in Alzheimer\u2019s disease","volume":"63","author":"Zeng","year":"2017","journal-title":"J. Mol. Neurosci."},{"key":"10.1016\/j.brainres.2024.148960_b0310","doi-asserted-by":"crossref","DOI":"10.1177\/1721727X221095383","article-title":"Inflammation\u2014Cause or consequence of late onset Alzheimer\u2019s disease or both? A review of the evidence","volume":"20","author":"Zhao","year":"2022","journal-title":"Eur. J. Inflamm."},{"key":"10.1016\/j.brainres.2024.148960_b0315","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/j.cellimm.2014.03.019","article-title":"Monocyte subsets in man and other species","volume":"289","author":"Ziegler-Heitbrock","year":"2014","journal-title":"Cell. Immunol."},{"key":"10.1016\/j.brainres.2024.148960_b0320","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1016\/S0196-9781(03)00131-1","article-title":"Humanin peptides block calcium influx of rat hippocampal neurons by altering fibrogenesis of A\u03b21\u201340","volume":"24","author":"Zou","year":"2003","journal-title":"Peptides"}],"container-title":["Brain Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006899324002142?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006899324002142?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T15:50:39Z","timestamp":1777391439000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006899324002142"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,8]]},"references-count":64,"alternative-id":["S0006899324002142"],"URL":"https:\/\/doi.org\/10.1016\/j.brainres.2024.148960","relation":{},"ISSN":["0006-8993"],"issn-type":[{"value":"0006-8993","type":"print"}],"subject":[],"published":{"date-parts":[[2024,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Systemic inflammation in A\u03b21-40-induced Alzheimer\u2019s disease model: New translational opportunities","name":"articletitle","label":"Article Title"},{"value":"Brain Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.brainres.2024.148960","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"148960"}}