{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T11:54:50Z","timestamp":1778673290963,"version":"3.51.4"},"reference-count":61,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T00:00:00Z","timestamp":1727740800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T00:00:00Z","timestamp":1727740800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T00:00:00Z","timestamp":1727740800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T00:00:00Z","timestamp":1727740800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T00:00:00Z","timestamp":1727740800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T00:00:00Z","timestamp":1727740800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T00:00:00Z","timestamp":1727740800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["clinicalkey.fr","clinicalkey.jp","clinicalkey.com.au","clinicalkey.es","clinicalkey.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Brain Research"],"published-print":{"date-parts":[[2024,10]]},"DOI":"10.1016\/j.brainres.2024.149049","type":"journal-article","created":{"date-parts":[[2024,5,31]],"date-time":"2024-05-31T16:38:30Z","timestamp":1717173510000},"page":"149049","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":11,"special_numbering":"C","title":["Unraveling the causal relationships between depression and brain structural imaging phenotypes: A bidirectional Mendelian Randomization study"],"prefix":"10.1016","volume":"1840","author":[{"given":"Wenqin","family":"Wang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wenhui","family":"Jia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shaoying","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ying","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhihui","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Minghuan","family":"Lei","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ying","family":"Zhai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jinglei","family":"Xu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jinghan","family":"Sun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wanwan","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yao","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yurong","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yifan","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mengge","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7332-1559","authenticated-orcid":false,"given":"Zuhao","family":"Sun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3570-4222","authenticated-orcid":false,"given":"Feng","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.brainres.2024.149049_b0005","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1503\/cmaj.080697","article-title":"Neurobiological mechanisms in major depressive disorder","volume":"180","author":"aan het Rot","year":"2009","journal-title":"CMAJ"},{"key":"10.1016\/j.brainres.2024.149049_b0010","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/j.jpsychires.2014.11.012","article-title":"Emotion dysregulation mediates the relationship between lifetime cumulative adversity and depressive symptomatology","volume":"61","author":"Abravanel","year":"2015","journal-title":"J. Psychiatr. Res."},{"key":"10.1016\/j.brainres.2024.149049_b0015","doi-asserted-by":"crossref","first-page":"1832","DOI":"10.1038\/s41591-023-02352-1","article-title":"Depression pathophysiology, risk prediction of recurrence and comorbid psychiatric disorders using genome-wide analyses","volume":"29","author":"Als","year":"2023","journal-title":"Nat. Med."},{"key":"10.1016\/j.brainres.2024.149049_b0020","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.biopsych.2011.11.022","article-title":"Cumulative adversity and smaller gray matter volume in medial prefrontal, anterior cingulate, and insula regions","volume":"72","author":"Ansell","year":"2012","journal-title":"Biol. Psychiatry."},{"key":"10.1016\/j.brainres.2024.149049_b0025","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1176\/appi.ajp.161.1.99","article-title":"Anterior cingulate, gyrus rectus, and orbitofrontal abnormalities in elderly depressed patients: an MRI-based parcellation of the prefrontal cortex","volume":"161","author":"Ballmaier","year":"2004","journal-title":"Am. J. Psychiatry"},{"key":"10.1016\/j.brainres.2024.149049_b0030","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1176\/appi.ajp.2016.16010010","article-title":"Appetite changes in depression","volume":"173","author":"Baxter","year":"2016","journal-title":"Am. J. Psychiatry"},{"key":"10.1016\/j.brainres.2024.149049_b0035","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1016\/j.tics.2004.10.003","article-title":"Conflict monitoring and anterior cingulate cortex: an update","volume":"8","author":"Botvinick","year":"2004","journal-title":"Trends Cogn Sci."},{"key":"10.1016\/j.brainres.2024.149049_b0040","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1093\/ije\/dyv080","article-title":"Mendelian randomization with invalid instruments: effect estimation and bias detection through Egger regression","volume":"44","author":"Bowden","year":"2015","journal-title":"Int. J. Epidemiol."},{"key":"10.1016\/j.brainres.2024.149049_b0045","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1002\/gepi.21965","article-title":"Consistent estimation in Mendelian randomization with some invalid instruments using a weighted median estimator","volume":"40","author":"Bowden","year":"2016","journal-title":"Genet. Epidemiol."},{"key":"10.1016\/j.brainres.2024.149049_b0050","doi-asserted-by":"crossref","first-page":"1264","DOI":"10.1093\/ije\/dyy101","article-title":"Improving the visualization, interpretation and analysis of two-sample summary data Mendelian randomization via the Radial plot and Radial regression","volume":"47","author":"Bowden","year":"2018","journal-title":"Int. J. Epidemiol."},{"key":"10.1016\/j.brainres.2024.149049_b0055","doi-asserted-by":"crossref","first-page":"658","DOI":"10.1002\/gepi.21758","article-title":"Mendelian randomization analysis with multiple genetic variants using summarized data","volume":"37","author":"Burgess","year":"2013","journal-title":"Genet. Epidemiol."},{"key":"10.1016\/j.brainres.2024.149049_b0060","doi-asserted-by":"crossref","first-page":"738","DOI":"10.1016\/j.jad.2023.12.045","article-title":"Genetic evidence suggests a genetic association between major depressive disorder and reduced cortical gray matter volume: A Mendelian randomization study and mediation analysis","volume":"351","author":"Cai","year":"2024","journal-title":"J. Affect. Disord."},{"key":"10.1016\/j.brainres.2024.149049_b0065","doi-asserted-by":"crossref","first-page":"1706","DOI":"10.1176\/appi.ajp.162.9.1706","article-title":"Subgenual prefrontal cortex volumes in major depressive disorder and schizophrenia: diagnostic specificity and prognostic implications","volume":"162","author":"Coryell","year":"2005","journal-title":"Am. J. Psychiatry"},{"key":"10.1016\/j.brainres.2024.149049_b0070","doi-asserted-by":"crossref","first-page":"1925","DOI":"10.1001\/jama.2017.17219","article-title":"Mendelian randomization","volume":"318","author":"Emdin","year":"2017","journal-title":"JAMA"},{"key":"10.1016\/j.brainres.2024.149049_b0075","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/j.tics.2010.11.004","article-title":"Emotional processing in anterior cingulate and medial prefrontal cortex","volume":"15","author":"Etkin","year":"2011","journal-title":"Trends Cogn. Sci."},{"key":"10.1016\/j.brainres.2024.149049_bib296","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1016\/j.nicl.2013.08.016","article-title":"Widespread reductions in gray matter volume in depression","volume":"3","author":"Grieve","year":"2013","journal-title":"Neuroimage Clin."},{"key":"10.1016\/j.brainres.2024.149049_b0080","doi-asserted-by":"crossref","first-page":"1019","DOI":"10.1152\/physrev.00006.2019","article-title":"Brain lateralization: a comparative perspective","volume":"100","author":"G\u00fcnt\u00fcrk\u00fcn","year":"2020","journal-title":"Physiol Rev."},{"key":"10.1016\/j.brainres.2024.149049_b0085","doi-asserted-by":"crossref","first-page":"1519","DOI":"10.1038\/s41593-022-01174-7","article-title":"Mendelian randomization analyses support causal relationships between brain imaging-derived phenotypes and risk of psychiatric disorders","volume":"25","author":"Guo","year":"2022","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.brainres.2024.149049_b0090","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1016\/j.biopsych.2010.09.034","article-title":"The subcallosal cingulate gyrus in the context of major depression","volume":"69","author":"Hamani","year":"2011","journal-title":"Biol. Psychiatry."},{"key":"10.1016\/j.brainres.2024.149049_b0095","doi-asserted-by":"crossref","first-page":"993","DOI":"10.1038\/mp.2008.57","article-title":"Amygdala volume in major depressive disorder: a meta-analysis of magnetic resonance imaging studies","volume":"13","author":"Hamilton","year":"2008","journal-title":"Mol. Psychiatry."},{"key":"10.1016\/j.brainres.2024.149049_b0100","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/j.jad.2013.10.021","article-title":"Cortical thickness, cortical and subcortical volume, and white matter integrity in patients with their first episode of major depression","volume":"155","author":"Han","year":"2014","journal-title":"J. Affect. Disord."},{"key":"10.1016\/j.brainres.2024.149049_b0105","doi-asserted-by":"crossref","first-page":"1985","DOI":"10.1093\/ije\/dyx102","article-title":"Robust inference in summary data Mendelian randomization via the zero modal pleiotropy assumption","volume":"46","author":"Hartwig","year":"2017","journal-title":"Int. J. Epidemiol."},{"key":"10.1016\/j.brainres.2024.149049_b0110","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.neures.2010.06.013","article-title":"Depression and the hyperactive right-hemisphere","volume":"68","author":"Hecht","year":"2010","journal-title":"Neurosci Res."},{"key":"10.1016\/j.brainres.2024.149049_b0115","article-title":"Orienting the causal relationship between imprecisely measured traits using GWAS summary data","volume":"13","author":"Hemani","year":"2017","journal-title":"PLoS Genet."},{"key":"10.1016\/j.brainres.2024.149049_b0120","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/j.bbr.2017.12.025","article-title":"Understanding the pathophysiology of depression: From monoamines to the neurogenesis hypothesis model \u2013 are we there yet?","volume":"341","author":"Jesulola","year":"2018","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.brainres.2024.149049_b0125","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.ebiom.2014.12.002","article-title":"Magnetic resonance imaging measures of brain structure to predict antidepressant treatment outcome in major depressive disorder","volume":"2","author":"Korgaonkar","year":"2015","journal-title":"EBioMedicine"},{"key":"10.1016\/j.brainres.2024.149049_b0130","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1016\/j.jad.2015.10.027","article-title":"Cortical abnormalities and association with symptom dimensions across the depressive spectrum","volume":"190","author":"Lener","year":"2016","journal-title":"J. Affect. Disord."},{"key":"10.1016\/j.brainres.2024.149049_b0135","doi-asserted-by":"crossref","first-page":"838","DOI":"10.1038\/npp.2011.264","article-title":"Regional cortical thickness and subcortical volume changes are associated with cognitive impairments in the drug-naive patients with late-onset depression","volume":"37","author":"Lim","year":"2012","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.brainres.2024.149049_b0140","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/j.cpr.2017.07.004","article-title":"Selection and implementation of emotion regulation strategies in major depressive disorder: An integrative review","volume":"57","author":"Liu","year":"2017","journal-title":"Clin. Psychol Rev."},{"key":"10.1016\/j.brainres.2024.149049_b0145","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1038\/s41588-021-00968-y","article-title":"Mendelian randomization analyses support causal relationships between blood metabolites and the gut microbiome","volume":"54","author":"Liu","year":"2022","journal-title":"Nat. Genet."},{"key":"10.1016\/j.brainres.2024.149049_b0150","doi-asserted-by":"crossref","first-page":"794","DOI":"10.1016\/j.jagp.2013.01.013","article-title":"Patterns of reduced cortical thickness in late-life depression and relationship to psychotherapeutic response","volume":"21","author":"Mackin","year":"2013","journal-title":"Am. J. Geriatr. Psychiatry."},{"key":"10.1016\/j.brainres.2024.149049_b0155","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1172\/JCI38454","article-title":"Targeted electrode-based modulation of neural circuits for depression","volume":"119","author":"Mayberg","year":"2009","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.brainres.2024.149049_bib297","doi-asserted-by":"crossref","DOI":"10.1038\/tp.2016.49","article-title":"Dimensions of depressive symptoms and cingulate volumes in older adults","volume":"6","author":"McLaren","year":"2016","journal-title":"Transl. Psychiatry"},{"key":"10.1016\/j.brainres.2024.149049_b0160","doi-asserted-by":"crossref","first-page":"917","DOI":"10.1006\/nimg.2001.1016","article-title":"Retrieval of visual, auditory, and abstract semantics","volume":"15","author":"Noppeney","year":"2002","journal-title":"Neuroimage"},{"key":"10.1016\/j.brainres.2024.149049_b0165","doi-asserted-by":"crossref","first-page":"329","DOI":"10.31887\/DCNS.2008.10.3\/dnutt","article-title":"Sleep disorders as core symptoms of depression","volume":"10","author":"Nutt","year":"2008","journal-title":"Dialogues Clin. Neurosci."},{"key":"10.1016\/j.brainres.2024.149049_b0170","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1038\/nn785","article-title":"Anatomic subdivisions in human temporal cortical neuronal activity related to recent verbal memory","volume":"5","author":"Ojemann","year":"2002","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.brainres.2024.149049_b0175","doi-asserted-by":"crossref","DOI":"10.1038\/nrdp.2016.65","article-title":"Major depressive disorder","volume":"2","author":"Otte","year":"2016","journal-title":"Nat. Rev. Dis. Primers"},{"key":"10.1016\/j.brainres.2024.149049_b0180","doi-asserted-by":"crossref","first-page":"1941","DOI":"10.1038\/s41467-019-09432-2","article-title":"Mendelian randomization analysis using mixture models for robust and efficient estimation of causal effects","volume":"10","author":"Qi","year":"2019","journal-title":"Nat. Commun."},{"key":"10.1016\/j.brainres.2024.149049_b0185","doi-asserted-by":"crossref","DOI":"10.1038\/tp.2014.18","article-title":"Regional increases of cortical thickness in untreated, first-episode major depressive disorder","volume":"4","author":"Qiu","year":"2014","journal-title":"Transl. Psychiatry."},{"key":"10.1016\/j.brainres.2024.149049_b0190","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1186\/1471-244X-14-83","article-title":"Cortical thickness in youth with major depressive disorder","volume":"14","author":"Reynolds","year":"2014","journal-title":"BMC Psychiatry"},{"key":"10.1016\/j.brainres.2024.149049_b0195","doi-asserted-by":"crossref","first-page":"1117","DOI":"10.1016\/j.cpr.2011.07.004","article-title":"Prevalence and clinical course of depression: a review","volume":"31","author":"Richards","year":"2011","journal-title":"Clin. Psychol. Rev."},{"key":"10.1016\/j.brainres.2024.149049_b0200","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.biopsych.2004.10.027","article-title":"Amygdala and hippocampus volumes in pediatric major depression","volume":"57","author":"Rosso","year":"2005","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.brainres.2024.149049_b0205","doi-asserted-by":"crossref","DOI":"10.1038\/s43586-021-00092-5","article-title":"Mendelian randomization","volume":"2","author":"Sanderson","year":"2022","journal-title":"Nat. Rev. Methods Primers"},{"key":"10.1016\/j.brainres.2024.149049_b0210","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1503\/jpn.090076","article-title":"Orbitofrontal volume reductions during emotion recognition in patients with major depression","volume":"35","author":"Scheuerecker","year":"2010","journal-title":"J. Psychiatry Neurosci."},{"key":"10.1016\/j.brainres.2024.149049_b0215","doi-asserted-by":"crossref","first-page":"900","DOI":"10.1038\/mp.2016.60","article-title":"Cortical abnormalities in adults and adolescents with major depression based on brain scans from 20 cohorts worldwide in the ENIGMA Major Depressive Disorder Working Group","volume":"22","author":"Schmaal","year":"2017","journal-title":"Mol. Psychiatry"},{"key":"10.1016\/j.brainres.2024.149049_b0220","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/j.neuron.2013.07.007","article-title":"The expected value of control: an integrative theory of anterior cingulate cortex function","volume":"79","author":"Shenhav","year":"2013","journal-title":"Neuron"},{"key":"10.1016\/j.brainres.2024.149049_b0225","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1038\/s41593-021-00826-4","article-title":"An expanded set of genome-wide association studies of brain imaging phenotypes in UK Biobank","volume":"24","author":"Smith","year":"2021","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.brainres.2024.149049_b0230","doi-asserted-by":"crossref","DOI":"10.1186\/s12864-021-07661-8","article-title":"Mendelian randomization studies of brain MRI yield insights into the pathogenesis of neuropsychiatric disorders","volume":"22","author":"Song","year":"2021","journal-title":"BMC Genomics"},{"key":"10.1016\/j.brainres.2024.149049_b0235","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.pscychresns.2007.03.005","article-title":"Reduced ventral anterior cingulate and amygdala volumes in medication-na\u00efve females with major depressive disorder: A voxel-based morphometric magnetic resonance imaging study","volume":"156","author":"Tang","year":"2007","journal-title":"Psychiatry Res."},{"key":"10.1016\/j.brainres.2024.149049_b0240","doi-asserted-by":"crossref","first-page":"812","DOI":"10.1016\/j.biopsych.2008.10.027","article-title":"Amygdala volume marks the acute state in the early course of depression","volume":"65","author":"van Eijndhoven","year":"2009","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.brainres.2024.149049_b0245","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1038\/s41588-018-0099-7","article-title":"Detection of widespread horizontal pleiotropy in causal relationships inferred from Mendelian randomization between complex traits and diseases","volume":"50","author":"Verbanck","year":"2018","journal-title":"Nat. Genet."},{"key":"10.1016\/j.brainres.2024.149049_b0250","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1017\/S0033291719000230","article-title":"The reductions in the subcallosal region cortical volume and surface area in major depressive disorder across the adult life span","volume":"50","author":"Wei","year":"2020","journal-title":"Psychol. Med."},{"key":"10.1016\/j.brainres.2024.149049_b0255","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1176\/appi.ajp.2013.13070920","article-title":"Structural brain development and depression onset during adolescence: a prospective longitudinal study","volume":"171","author":"Whittle","year":"2014","journal-title":"Am. J. Psychiatry"},{"key":"10.1016\/j.brainres.2024.149049_b0260","doi-asserted-by":"crossref","unstructured":"Wise, T., Radua, J., Via, E., Cardoner, N., Abe, O., Adams, T.M., Amico, F., Cheng, Y., Cole, J.H., de Azevedo Marques Perico, C., Dickstein, D.P., Farrow, T.F.D., Frodl, T., Wagner, G., Gotlib, I.H., Gruber, O., Ham, B.J., Job, D.E., Kempton, M.J., Kim, M.J., Koolschijn, P., Malhi, G.S., Mataix-Cols, D., McIntosh, A.M., Nugent, A.C., O'Brien, J.T., Pezzoli, S., Phillips, M.L., Sachdev, P.S., Salvadore, G., Selvaraj, S., Stanfield, A.C., Thomas, A.J., van Tol, M.J., van der Wee, N.J.A., Veltman, D.J., Young, A.H., Fu, C.H., Cleare, A.J., Arnone, D., 2017. Common and distinct patterns of grey-matter volume alteration in major depression and bipolar disorder: evidence from voxel-based meta-analysis. Mol. Psychiatry 22, 1455-1463.","DOI":"10.1038\/mp.2016.72"},{"key":"10.1016\/j.brainres.2024.149049_b0265","doi-asserted-by":"crossref","first-page":"1569","DOI":"10.1038\/s41562-022-01412-9","article-title":"Bidirectional two-sample Mendelian randomization analysis identifies causal associations between relative carbohydrate intake and depression","volume":"6","author":"Yao","year":"2022","journal-title":"Nat Hum. Behav."},{"key":"10.1016\/j.brainres.2024.149049_b0270","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1186\/s12916-023-02982-9","article-title":"Assessment of bidirectional relationships between brain imaging-derived phenotypes and stroke: a Mendelian randomization study","volume":"21","author":"Yu","year":"2023","journal-title":"BMC Med."},{"key":"10.1016\/j.brainres.2024.149049_b0275","doi-asserted-by":"crossref","first-page":"3157","DOI":"10.1038\/npp.2008.40","article-title":"Anterior cingulate volumes in never-treated patients with major depressive disorder","volume":"33","author":"Yucel","year":"2008","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.brainres.2024.149049_b0280","doi-asserted-by":"crossref","first-page":"810","DOI":"10.1016\/j.biopsych.2023.11.006","article-title":"Brainwide mendelian randomization study of anxiety disorders and symptoms","volume":"95","author":"Zanoaga","year":"2024","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.brainres.2024.149049_b0285","doi-asserted-by":"crossref","first-page":"1637","DOI":"10.1038\/s41588-019-0516-6","article-title":"Genome-wide association analysis of 19,629 individuals identifies variants influencing regional brain volumes and refines their genetic co-architecture with cognitive and mental health traits","volume":"51","author":"Zhao","year":"2019","journal-title":"Nat. Genet."},{"key":"10.1016\/j.brainres.2024.149049_b0290","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1038\/s41398-023-02492-5","article-title":"Dissecting the causal association between social or physical inactivity and depression: a bidirectional two-sample Mendelian Randomization study","volume":"13","author":"Zhao","year":"2023","journal-title":"Transl. Psychiatry"},{"key":"10.1016\/j.brainres.2024.149049_b0295","doi-asserted-by":"crossref","first-page":"1742","DOI":"10.1214\/19-AOS1866","article-title":"Statistical inference in two-sample summary-data Mendelian randomization using robust adjusted profile score","volume":"48","author":"Zhao","year":"2020","journal-title":"Ann. Statist."}],"container-title":["Brain Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006899324003032?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006899324003032?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,8,10]],"date-time":"2024-08-10T18:53:29Z","timestamp":1723316009000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006899324003032"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,10]]},"references-count":61,"alternative-id":["S0006899324003032"],"URL":"https:\/\/doi.org\/10.1016\/j.brainres.2024.149049","relation":{},"ISSN":["0006-8993"],"issn-type":[{"value":"0006-8993","type":"print"}],"subject":[],"published":{"date-parts":[[2024,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Unraveling the causal relationships between depression and brain structural imaging phenotypes: A bidirectional Mendelian Randomization study","name":"articletitle","label":"Article Title"},{"value":"Brain Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.brainres.2024.149049","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"149049"}}