{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T17:39:30Z","timestamp":1792690770854,"version":"4.5.0"},"reference-count":41,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81971114"],"award-info":[{"award-number":["81971114"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82274401"],"award-info":[{"award-number":["82274401"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81473591"],"award-info":[{"award-number":["81473591"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.fr","clinicalkey.jp","clinicalkey.com.au","clinicalkey.es","clinicalkey.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Brain Research"],"published-print":{"date-parts":[[2024,11]]},"DOI":"10.1016\/j.brainres.2024.149098","type":"journal-article","created":{"date-parts":[[2024,6,26]],"date-time":"2024-06-26T15:31:56Z","timestamp":1719415916000},"page":"149098","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":10,"special_numbering":"C","title":["Ginseng aconitum decoction (Shenfu Tang) provides neuroprotection by ameliorating impairment of blood\u2013brain barrier in cerebral ischemia\u2013reperfusion injury"],"prefix":"10.1016","volume":"1842","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7644-1118","authenticated-orcid":false,"given":"Wei","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Changhong","family":"Ren","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fang","family":"Tong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaodan","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.brainres.2024.149098_b0005","doi-asserted-by":"crossref","unstructured":"Al-Atta, Ayman, Micha\u0142 Kuzemczak., Mohammad Alkhalil, 2021. Colchicine for the prevention of ischemic stroke: An updated meta-analysis of randomized clinical trials, Brain Circ. 7 (3):187-193. doi: 10.4103\/bc.bc_24_21.","DOI":"10.4103\/bc.bc_24_21"},{"key":"10.1016\/j.brainres.2024.149098_b0010","doi-asserted-by":"crossref","first-page":"3591","DOI":"10.2147\/DDDT.S218708","article-title":"In-vitro blood-brain barrier models for drug screening and permeation studies: an overview","volume":"13","author":"Bagchi","year":"2019","journal-title":"Drug Design, Development Therapy"},{"key":"10.1016\/j.brainres.2024.149098_b0015","doi-asserted-by":"crossref","unstructured":"Benjamin, Emelia J, Michael J Blaha, Stephanie E Chiuve, Mary Cushman, Sandeep R Das, Rajat Deo, Sarah D de Ferranti, James Floyd, Myriam Fornage, Cathleen Gillespie, Carmen R Isasi, Monik C Jim\u00e9nez, Lori Chaffin Jordan, Suzanne E Judd, Daniel Lackland, Judith H Lichtman, Lynda Lisabeth, Simin Liu, Chris T Longenecker, Rachel H Mackey, Kunihiro Matsushita, Dariush Mozaffarian, Michael E Mussolino, Khurram Nasir, Robert W Neumar, Latha Palaniappan, Dilip K Pandey, Ravi R Thiagarajan, Mathew J Reeves, Matthew Ritchey, Carlos J Rodriguez, Gregory A Roth, Wayne D Rosamond, Comilla Sasson, Amytis Towfighi, Connie W Tsao, Melanie B Turner, Salim S Virani, Jenifer H Voeks, Joshua Z Willey, John T Wilkins, Jason Hy Wu, Heather M Alger, Sally S Wong, Paul Muntner, American Heart Association Statistics Committee, and Stroke Statistics Subcommittee. 2017. Heart Disease and Stroke Statistics-2017 Update: A Report From the American Heart Association. Circulation 135 (10):e146-e603. doi: 10.1161\/cir.0000000000000485.","DOI":"10.1161\/CIR.0000000000000485"},{"issue":"1","key":"10.1016\/j.brainres.2024.149098_b0020","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1038\/s41572-019-0118-8","article-title":"Ischaemic stroke","volume":"5","author":"Campbell","year":"2019","journal-title":"Nat. Rev. Dis. Primers"},{"issue":"3","key":"10.1016\/j.brainres.2024.149098_b0025","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1161\/CIRCRESAHA.116.309278","article-title":"Acute Ischemic Stroke Therapy Overview","volume":"120","author":"Catanese","year":"2017","journal-title":"Circ. Res."},{"issue":"14","key":"10.1016\/j.brainres.2024.149098_b0030","doi-asserted-by":"crossref","first-page":"1556","DOI":"10.1016\/j.scib.2023.06.017","article-title":"Hypothermic neuroprotection by targeted cold autologous blood transfusion in a non-human primate stroke model","volume":"68","author":"Chen","year":"2023","journal-title":"Sci. Bull."},{"key":"10.1016\/j.brainres.2024.149098_b0035","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2024.155627","article-title":"Shenfu injection targets the PI3K-AKT pathway to regulate autophagy and apoptosis in acute respiratory distress syndrome caused by sepsis","volume":"129","author":"Chen","year":"2024","journal-title":"Phytomedicine"},{"issue":"3","key":"10.1016\/j.brainres.2024.149098_b0040","first-page":"226","article-title":"Shenfu injection attenuates lipopolysaccharide-induced myocardial inflammation and apoptosis in rats","volume":"18","author":"Chen","year":"2020","journal-title":"Chin. J. Nat. Med."},{"key":"10.1016\/j.brainres.2024.149098_b0045","first-page":"4588999","article-title":"Shenfu injection protects brain injury in rats with cardiac arrest through Nogo\/NgR pathway","volume":"2022","author":"Deng","year":"2022","journal-title":"Anal. Cell. Pathol. (Amst.)"},{"issue":"1","key":"10.1016\/j.brainres.2024.149098_b0050","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1186\/1752-153X-7-165","article-title":"Quantitative LC-MS\/MS analysis of seven ginsenosides and three aconitum alkaloids in Shen-Fu decoction","volume":"7","author":"Guo","year":"2013","journal-title":"Chem. Cent. J."},{"issue":"3","key":"10.1016\/j.brainres.2024.149098_b0055","doi-asserted-by":"crossref","first-page":"201","DOI":"10.4103\/bc.bc_19_21","article-title":"Disparities among neurointerventionalists suggest further investigation of conscious sedation versus general anesthesia during thrombectomy for acute stroke","volume":"7","author":"Inam","year":"2021","journal-title":"Brain Circ."},{"key":"10.1016\/j.brainres.2024.149098_b0060","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1016\/j.pneurobio.2017.10.001","article-title":"Blood-brain barrier dysfunction and recovery after ischemic stroke","volume":"163\u2013164","author":"Jiang","year":"2018","journal-title":"Prog. Neurobiol."},{"issue":"6","key":"10.1016\/j.brainres.2024.149098_b0065","doi-asserted-by":"crossref","first-page":"881","DOI":"10.1016\/j.cmet.2018.07.016","article-title":"Quiescent Endothelial Cells Upregulate Fatty Acid \u03b2-Oxidation for Vasculoprotection via Redox Homeostasis","volume":"28","author":"Kalucka","year":"2018","journal-title":"Cell Metab."},{"issue":"1","key":"10.1016\/j.brainres.2024.149098_b0070","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1186\/s12974-020-1727-6","article-title":"CLEC14A deficiency exacerbates neuronal loss by increasing blood-brain barrier permeability and inflammation","volume":"17","author":"Kim","year":"2020","journal-title":"J. Neuroinflammation"},{"issue":"1","key":"10.1016\/j.brainres.2024.149098_b0075","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/j.colsurfb.2011.04.005","article-title":"Effect of human astrocytes on the characteristics of human brain-microvascular endothelial cells in the blood-brain barrier","volume":"86","author":"Kuo","year":"2011","journal-title":"Colloids Surf., B, Biointerfaces"},{"key":"10.1016\/j.brainres.2024.149098_b0080","doi-asserted-by":"crossref","unstructured":"Lee, Hyun Joo, Yong-ho Lee, Sang Kyu Park, Eun Seok Kang, Hyo-Jeong Kim, Young Chul Lee, Cheol Soo Choi, Se Eun Park, Chul Woo Ahn, Bong Soo Cha, Kwan Woo Lee, Kyung-Sup Kim, Sung Kil Lim, and Hyun Chul Lee. 2009. \u201cKorean red ginseng (Panax ginseng) improves insulin sensitivity and attenuates the development of diabetes in Otsuka Long-Evans Tokushima fatty rats.\u201d Metabolism: clinical experimental 58 (8):1170-7. doi: 10.1016\/j.metabol.2009.03.015.","DOI":"10.1016\/j.metabol.2009.03.015"},{"issue":"11","key":"10.1016\/j.brainres.2024.149098_b0085","doi-asserted-by":"crossref","first-page":"3059","DOI":"10.1038\/s41596-019-0212-0","article-title":"The isolation and molecular characterization of cerebral microvessels","volume":"14","author":"Lee","year":"2019","journal-title":"Nat. Protoc."},{"issue":"1","key":"10.1016\/j.brainres.2024.149098_b0090","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jgr.2016.12.005","article-title":"Ginseng and obesity","volume":"42","author":"Li","year":"2018","journal-title":"J. Ginseng Res."},{"key":"10.1016\/j.brainres.2024.149098_b0095","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1146\/annurev-physiol-020518-114731","article-title":"Metabolic pathways fueling the endothelial cell drive","volume":"81","author":"Li","year":"2019","journal-title":"Annu. Rev. Physiol."},{"issue":"12","key":"10.1016\/j.brainres.2024.149098_b0100","doi-asserted-by":"crossref","DOI":"10.1084\/jem.20200213","article-title":"Brain transforms natural killer cells that exacerbate brain edema after intracerebral hemorrhage","volume":"217","author":"Li","year":"2020","journal-title":"J. Exp. Med."},{"issue":"3","key":"10.1016\/j.brainres.2024.149098_b0105","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1007\/s00401-018-1815-1","article-title":"Functional morphology of the blood-brain barrier in health and disease","volume":"135","author":"Liebner","year":"2018","journal-title":"Acta Neuropathol."},{"key":"10.1016\/j.brainres.2024.149098_b0110","article-title":"Feasibility and mechanism analysis of Shenfu injection in the treatment of idiopathic pulmonary fibrosis","volume":"12","author":"Liu","year":"2021","journal-title":"Front. Pharmacol."},{"issue":"6","key":"10.1016\/j.brainres.2024.149098_b0115","doi-asserted-by":"crossref","first-page":"1223","DOI":"10.1142\/S0192415X19500629","article-title":"Application of Chinese medicine in acute and critical medical conditions","volume":"47","author":"Luo","year":"2019","journal-title":"Am. J. Chin. Med."},{"issue":"3","key":"10.1016\/j.brainres.2024.149098_b0120","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1016\/j.cmet.2018.06.002","article-title":"Etomoxir actions on regulatory and memory T cells are independent of cpt1a-mediated fatty acid oxidation","volume":"28","author":"Raud","year":"2018","journal-title":"Cell Metab."},{"issue":"4","key":"10.1016\/j.brainres.2024.149098_b0125","doi-asserted-by":"crossref","first-page":"245","DOI":"10.14336\/AD.2014.1126","article-title":"Herbal Formula Danggui-Shaoyao-San promotes neurogenesis and angiogenesis in rat following middle cerebral artery occlusion","volume":"6","author":"Ren","year":"2015","journal-title":"Aging Dis."},{"issue":"20 Suppl 2","key":"10.1016\/j.brainres.2024.149098_b0130","first-page":"S6","article-title":"Global epidemiology of stroke and access to acute ischemic stroke interventions","volume":"97","author":"Saini","year":"2021","journal-title":"Neurology"},{"issue":"1","key":"10.1016\/j.brainres.2024.149098_b0135","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1186\/s12974-019-1638-6","article-title":"The glucagon-like peptide-1 receptor agonist reduces inflammation and blood-brain barrier breakdown in an astrocyte-dependent manner in experimental stroke","volume":"16","author":"Shan","year":"2019","journal-title":"J. Neuroinflammation"},{"key":"10.1016\/j.brainres.2024.149098_b0140","doi-asserted-by":"crossref","first-page":"10523","DOI":"10.1038\/ncomms10523","article-title":"Rapid endothelial cytoskeletal reorganization enables early blood-brain barrier disruption and long-term ischaemic reperfusion brain injury","volume":"7","author":"Shi","year":"2016","journal-title":"Nat. Commun."},{"issue":"3","key":"10.1016\/j.brainres.2024.149098_b0145","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1117\/1.JBO.24.3.031014","article-title":"Simultaneous infrared thermal imaging and laser speckle imaging of brain temperature and cerebral blood flow in rats","volume":"24","author":"Suzuki","year":"2018","journal-title":"J. Biomed. Opt."},{"issue":"1","key":"10.1016\/j.brainres.2024.149098_b0150","first-page":"22","article-title":"Intravenous thrombolysis in expanded time window (3\u20134.5 hours) in general practice with concurrent availability of endovascular treatment","volume":"5","author":"Tekle","year":"2012","journal-title":"J. Vasc. Interv. Neurol."},{"key":"10.1016\/j.brainres.2024.149098_b0155","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1016\/j.jep.2015.04.016","article-title":"Shenfu decoction as adjuvant therapy for improving quality of life and hepatic dysfunction in patients with symptomatic chronic heart failure","volume":"169","author":"Wei","year":"2015","journal-title":"J. Ethnopharmacol."},{"issue":"9","key":"10.1016\/j.brainres.2024.149098_b0160","doi-asserted-by":"crossref","first-page":"2054","DOI":"10.1038\/s41596-022-00707-5","article-title":"A clinically relevant model of focal embolic cerebral ischemia by thrombus and thrombolysis in rhesus monkeys","volume":"17","author":"Wu","year":"2022","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.brainres.2024.149098_b0165","article-title":"Evaluation of the efficacy and safety of chinese herbal injection combined with trimetazidine for viral myocarditis: a network meta-analysis","volume":"12","author":"Wu","year":"2021","journal-title":"Front. Pharmacol."},{"issue":"2","key":"10.1016\/j.brainres.2024.149098_b0170","doi-asserted-by":"crossref","first-page":"175","DOI":"10.3233\/CH-211100","article-title":"Shenfu injection improves cerebral microcirculation and reduces brain injury in a porcine model of hemorrhagic shock","volume":"78","author":"Wu","year":"2021","journal-title":"Clin. Hemorheol. Microcirc."},{"issue":"4","key":"10.1016\/j.brainres.2024.149098_b0175","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1016\/j.molcel.2018.01.010","article-title":"A metabolic basis for endothelial-to-mesenchymal transition","volume":"69","author":"Xiong","year":"2018","journal-title":"Mol. Cell"},{"key":"10.1016\/j.brainres.2024.149098_b0180","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/j.jep.2018.05.006","article-title":"Shenfu Formula reduces cardiomyocyte apoptosis in heart failure rats by regulating microRNAs","volume":"227","author":"Yan","year":"2018","journal-title":"J. Ethnopharmacol."},{"issue":"9","key":"10.1016\/j.brainres.2024.149098_b0185","doi-asserted-by":"crossref","first-page":"1571","DOI":"10.1007\/s10072-013-1288-x","article-title":"Shenfu injection attenuates neonatal hypoxic-ischemic brain damage in rat","volume":"34","author":"Yang","year":"2013","journal-title":"Neurol. Sci."},{"issue":"1","key":"10.1016\/j.brainres.2024.149098_b0190","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1007\/s11655-016-2616-9","article-title":"Effects of Shenfu Injection ( on cerebral metabolism in a porcine model of cardiac arrest","volume":"23","author":"Yin","year":"2017","journal-title":"Chin. J. Integr. Med."},{"key":"10.1016\/j.brainres.2024.149098_b0195","article-title":"Hypoxic postconditioning drives protective microglial responses and ameliorates white matter injury after ischemic stroke","author":"Zhang","year":"2023","journal-title":"CNS Neurosci. Ther."},{"key":"10.1016\/j.brainres.2024.149098_b0200","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1016\/j.phrs.2019.04.021","article-title":"Ginsenoside F1 promotes angiogenesis by activating the IGF-1\/IGF1R pathway","volume":"144","author":"Zhang","year":"2019","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.brainres.2024.149098_b0205","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.phymed.2017.01.009","article-title":"Serum metabolomics analysis reveals that obvious cardioprotective effects of low dose Sini decoction against isoproterenol-induced myocardial injury in rats","volume":"31","author":"Zhou","year":"2017","journal-title":"Phytomedicine"}],"container-title":["Brain Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006899324003524?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006899324003524?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,8,23]],"date-time":"2024-08-23T23:44:45Z","timestamp":1724456685000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006899324003524"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,11]]},"references-count":41,"alternative-id":["S0006899324003524"],"URL":"https:\/\/doi.org\/10.1016\/j.brainres.2024.149098","relation":{},"ISSN":["0006-8993"],"issn-type":[{"value":"0006-8993","type":"print"}],"subject":[],"published":{"date-parts":[[2024,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Ginseng aconitum decoction (Shenfu Tang) provides neuroprotection by ameliorating impairment of blood\u2013brain barrier in cerebral ischemia\u2013reperfusion injury","name":"articletitle","label":"Article Title"},{"value":"Brain Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.brainres.2024.149098","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"149098"}}