{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T04:14:30Z","timestamp":1787631270972,"version":"build-2736575974"},"reference-count":38,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100010031","name":"Postdoctoral Research Foundation of China","doi-asserted-by":"publisher","award":["2021M700083"],"award-info":[{"award-number":["2021M700083"]}],"id":[{"id":"10.13039\/501100010031","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002858","name":"China Postdoctoral Science Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002858","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007129","name":"Shandong Province Natural Science Foundation","doi-asserted-by":"publisher","award":["ZR2023QH035"],"award-info":[{"award-number":["ZR2023QH035"]}],"id":[{"id":"10.13039\/501100007129","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Brain Research"],"published-print":{"date-parts":[[2025,1]]},"DOI":"10.1016\/j.brainres.2024.149292","type":"journal-article","created":{"date-parts":[[2024,10,24]],"date-time":"2024-10-24T12:21:45Z","timestamp":1729772505000},"page":"149292","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"special_numbering":"C","title":["A coloaded liposome in situ gel as a novel therapeutic strategy to treat cerebral ischemia reperfusion injury"],"prefix":"10.1016","volume":"1847","author":[{"given":"Qiang","family":"Tian","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rongbin","family":"Lv","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guangan","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinyun","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanfen","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Baoliang","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhangyong","family":"Xia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.brainres.2024.149292_b0005","article-title":"Passive and active targeting in cancer therapy by liposomes and lipid nanoparticles","volume":"34","author":"Alavi","year":"2019","journal-title":"Drug Metab. Pers. Ther."},{"key":"10.1016\/j.brainres.2024.149292_b0010","article-title":"Intranasal nerve growth factor administration improves neurological outcome after GBS meningitis","volume":"36","author":"Antonio","year":"2020","journal-title":"Childs Nerv. Syst."},{"key":"10.1016\/j.brainres.2024.149292_b0015","article-title":"UPEI-300, a conjugate of lipoic acid and edaravone, mediates neuroprotection in ischemia\/reperfusion","volume":"561","author":"Barry","year":"2014","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.brainres.2024.149292_b0020","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.lfs.2017.12.025","article-title":"Mechanism of intranasal drug delivery directly to the brain","volume":"195","author":"Crowe","year":"2018","journal-title":"Life Sci."},{"key":"10.1016\/j.brainres.2024.149292_b0025","article-title":"The synergetic effect of edaravone and borneol in the rat model of ischemic stroke","volume":"740","author":"Hai-Yin","year":"2014","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.brainres.2024.149292_b0030","article-title":"A novel delivery system of cyclovirobuxine D for brain targeting: angiopep-conjugated polysorbate 80-coated liposomes via intranasal administration","volume":"14","author":"Hanmei","year":"2018","journal-title":"J. Biomed. Nanotechnol."},{"key":"10.1016\/j.brainres.2024.149292_b0035","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1007\/s10157-008-0108-8","article-title":"Determinants for the prognosis of acute renal disorders that developed during or after treatment with edaravone","volume":"13","author":"Hishida","year":"2009","journal-title":"Clin. Exp. Nephrol."},{"key":"10.1016\/j.brainres.2024.149292_b0040","article-title":"LA67 liposome-loaded thermo-sensitive hydrogel with active targeting for efficient treatment of keloid via peritumoral injection","volume":"15","author":"Hongshuang","year":"2023","journal-title":"Pharmaceutics"},{"key":"10.1016\/j.brainres.2024.149292_b0045","article-title":"The autophagic and apoptotic death of forebrain neurons of rats with global brain ischemia is diminished by the intranasal administration of insulin: possible mechanism of its action","volume":"46","author":"Irina","year":"2024","journal-title":"Curr. Issues Mol. Biol."},{"key":"10.1016\/j.brainres.2024.149292_b0050","doi-asserted-by":"crossref","first-page":"2427","DOI":"10.1007\/s11095-013-1148-7","article-title":"Brain drug delivery systems","volume":"30","author":"Jiang","year":"2013","journal-title":"Pharm. Res."},{"key":"10.1016\/j.brainres.2024.149292_b0055","article-title":"Brain targeting of citicoline sodium via hyaluronic acid-decorated novel nano-transbilosomes for mitigation of Alzheimer\u2019s disease in a rat model: formulation, optimization, in vitro and in vivo assessment","volume":"17","author":"Kariman","year":"2022","journal-title":"Int. J. Nanomed."},{"key":"10.1016\/j.brainres.2024.149292_b0060","article-title":"A review of chitosan-based nanocarriers as drug delivery systems for brain diseases: critical challenges, outlooks and promises","volume":"278","author":"Khashayar","year":"2024","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.brainres.2024.149292_b0065","doi-asserted-by":"crossref","DOI":"10.2174\/2210303109666190926110927","article-title":"Nasal in-situ gel: an approach to enhance therapeutic benefits of the drug","author":"Khatri","year":"2020","journal-title":"Drug Deliv. Lett."},{"key":"10.1016\/j.brainres.2024.149292_b0070","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1016\/j.jgr.2018.12.002","article-title":"Ginsenoside Rb2 suppresses the glutamate-mediated oxidative stress and neuronal cell death in HT22 cells","volume":"43","author":"Kim","year":"2019","journal-title":"J. Ginseng Res."},{"key":"10.1016\/j.brainres.2024.149292_b0075","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1080\/10717544.2019.1571122","article-title":"A more efficient ocular delivery system of triamcinolone acetonide as eye drop to the posterior segment of the eye","volume":"26","author":"Li","year":"2019","journal-title":"Drug Deliv."},{"key":"10.1016\/j.brainres.2024.149292_b0080","article-title":"A novel, liposome-loaded, injectable hydrogel for enhanced treatment of choroidal neovascularization by sub-tenon\u2019s injection","volume":"20","author":"Li","year":"2022","journal-title":"Mater. Today Nano"},{"key":"10.1016\/j.brainres.2024.149292_b0085","unstructured":"Li, Q., Liu, Y., Chen, L. 2018. Effects of PPAR\u03b3 agonist decreasing the IL-1\u03b2, IL-6 and TNF-\u03b1 content in rats on focal cerebral ischemia-reperfusion injury."},{"key":"10.1016\/j.brainres.2024.149292_b0090","article-title":"Curcumin alleviates cerebral ischemia-reperfusion injury by inhibiting NLRP1-dependent neuronal pyroptosis","volume":"18","author":"Lifa","year":"2021","journal-title":"Curr. Neurovasc. Res."},{"key":"10.1016\/j.brainres.2024.149292_b0095","doi-asserted-by":"crossref","DOI":"10.3892\/br.2013.153","article-title":"Effects of apoptosis-related proteins caspase-3, Bax and Bcl-2 on cerebral ischemia rats","author":"Liu","year":"2013","journal-title":"Biomed. Rep."},{"key":"10.1016\/j.brainres.2024.149292_b0100","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2022.154111","article-title":"Ligustilide ameliorates hippocampal neuronal injury after cerebral ischemia reperfusion through activating PINK1\/Parkin-dependent mitophagy","volume":"101","author":"Mao","year":"2022","journal-title":"Phytomedicine"},{"key":"10.1016\/j.brainres.2024.149292_b0105","article-title":"Stabilizers of edaravone aqueous solution and their action mechanisms. 2. Glutathione","volume":"61","author":"Masahiko","year":"2017","journal-title":"J. Clin. Biochem. Nutr."},{"key":"10.1016\/j.brainres.2024.149292_b0110","article-title":"Advances in pathogenesis of cerebral ischemia reperfusion injury and the treatment of modern traditional Chinese medicine","author":"Mengnan","year":"2019","journal-title":"J. Changchun Univ. Chin. Med."},{"key":"10.1016\/j.brainres.2024.149292_b0115","article-title":"Reperfusion therapies for acute ischemic stroke: current pharmacological and mechanical approaches","author":"Molina","year":"2010","journal-title":"Stroke"},{"key":"10.1016\/j.brainres.2024.149292_b0120","doi-asserted-by":"crossref","DOI":"10.1016\/j.expneurol.2020.113518","article-title":"Emerging neuroprotective strategies for the treatment of ischemic stroke: an overview of clinical and preclinical studies","volume":"335","author":"Paul","year":"2021","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.brainres.2024.149292_b0125","article-title":"Brain delivery of intranasalin situgel of nanoparticulated polymeric carriers containing antidepressant drug: behavioral and biochemical assessment","author":"Prabhjot","year":"2014","journal-title":"J. Drug Target."},{"key":"10.1016\/j.brainres.2024.149292_b0130","article-title":"Ginsenoside Rb2 inhibits p300-mediated SF3A2 acetylation at lysine 10 to promote Fscn1 alternative splicing against myocardial ischemic\/reperfusion injury","author":"Qingxia","year":"2023","journal-title":"J. Adv. Res."},{"key":"10.1016\/j.brainres.2024.149292_b0135","doi-asserted-by":"crossref","first-page":"S982","DOI":"10.1080\/21691401.2018.1523181","article-title":"Amelioration of ischaemia reperfusion-induced cerebral injury in mice by liposomes containing Allium cepa fraction administered intranasally","volume":"46","author":"Singh","year":"2018","journal-title":"Artif. Cells Nanomed. Biotechnol."},{"key":"10.1016\/j.brainres.2024.149292_b0140","article-title":"miR-328-3p, a predictor of stroke, aggravates the cerebral ischemia-reperfusion injury","author":"Wang","year":"2021","journal-title":"Int. J. General Med."},{"key":"10.1016\/j.brainres.2024.149292_b0145","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1177\/1747493017694391","article-title":"2014 Chinese guidelines for secondary prevention of ischemic stroke and transient ischemic attack","volume":"12","author":"Wang","year":"2017","journal-title":"Int. J. Stroke"},{"key":"10.1016\/j.brainres.2024.149292_b0150","article-title":"Progress on the mechanisms of cerebral ischemia reperfusion injury","author":"Xian-Fu","year":"2010","journal-title":"Med. Recapitulate"},{"key":"10.1016\/j.brainres.2024.149292_b0155","doi-asserted-by":"crossref","first-page":"166230-","DOI":"10.1016\/j.bbadis.2021.166230","article-title":"Orexin-A alleviates astrocytic apoptosis and inflammation via inhibiting OX1R-mediated NF-\u03baB and MAPK signaling pathways in cerebral ischemia\/reperfusion injury","volume":"1867","author":"Xu","year":"2021","journal-title":"Biochimica et Biophysica Acta (BBA)"},{"key":"10.1016\/j.brainres.2024.149292_b0160","article-title":"Ginsenoside Rb2 alleviates myocardial ischemia\/reperfusion injury in rats through SIRT1 activation","volume":"85","author":"Yan","year":"2020","journal-title":"J. Food Sci."},{"key":"10.1016\/j.brainres.2024.149292_b0165","article-title":"Protective effect of liquiritin against cerebral ischemia\/reperfusion inflammatory injury in mice","author":"Ya-Xuan","year":"2010","journal-title":"Food Sci."},{"key":"10.1016\/j.brainres.2024.149292_b0170","article-title":"Chrysophanol attenuates nitrosative\/oxidative stress injury in a mouse model of focal cerebral ischemia\/reperfusion","volume":"138","author":"Yongmei","year":"2018","journal-title":"J. Pharmacol. Sci."},{"key":"10.1016\/j.brainres.2024.149292_b0175","article-title":"Effect of ginsenoside Rb2 on a myocardial cell model of coronary heart disease through Nrf2\/HO-1 signaling pathway","volume":"45","author":"Yuning","year":"2022","journal-title":"Biol. Pharm Bull."},{"key":"10.1016\/j.brainres.2024.149292_b0180","article-title":"Neuroprotective effect of wild lowbush blueberry (Vaccinium angustifolium) on global cerebral ischemia\/reperfusion injury in rats: downregulation of iNOS\/TNF-\u03b1 and upregulation of miR-146a\/miR-21 expression","volume":"35","author":"Zahra","year":"2021","journal-title":"Phytother. Res."},{"key":"10.1016\/j.brainres.2024.149292_b0185","doi-asserted-by":"crossref","DOI":"10.1007\/s12031-023-02135-w","article-title":"Isoflurane enhances autophagy by activating AMPK\/ULK1, inhibits NLRP3, and reduces cognitive impairment after cerebral ischemia-reperfusion injury in rats","author":"Zhai","year":"2023","journal-title":"J. Mol. Neurosci."},{"key":"10.1016\/j.brainres.2024.149292_b0190","doi-asserted-by":"crossref","first-page":"986","DOI":"10.1111\/cbdd.13956","article-title":"Pinoresinol diglucoside alleviates ischemia\/reperfusion-induced brain injury by modulating neuroinflammation and oxidative stress","volume":"98","author":"Zhang","year":"2021","journal-title":"Chem. Biol. Drug Des."}],"container-title":["Brain Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006899324005468?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006899324005468?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,18]],"date-time":"2025-10-18T21:34:46Z","timestamp":1760823286000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006899324005468"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1]]},"references-count":38,"alternative-id":["S0006899324005468"],"URL":"https:\/\/doi.org\/10.1016\/j.brainres.2024.149292","relation":{},"ISSN":["0006-8993"],"issn-type":[{"value":"0006-8993","type":"print"}],"subject":[],"published":{"date-parts":[[2025,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"A coloaded liposome in situ gel as a novel therapeutic strategy to treat cerebral ischemia reperfusion injury","name":"articletitle","label":"Article Title"},{"value":"Brain Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.brainres.2024.149292","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"149292"}}