{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T12:11:49Z","timestamp":1789647109785,"version":"4.0.0"},"reference-count":33,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81960222"],"award-info":[{"award-number":["81960222"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004317","name":"Shihezi University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004317","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Brain Research"],"published-print":{"date-parts":[[2024,12]]},"DOI":"10.1016\/j.brainres.2024.149293","type":"journal-article","created":{"date-parts":[[2024,10,23]],"date-time":"2024-10-23T11:45:30Z","timestamp":1729683930000},"page":"149293","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"special_numbering":"C","title":["Neuritin attenuates neuroinflammation and apoptosis in early brain injury after subarachnoid hemorrhage via endoplasmic reticulum stress-related inflammatory pathways"],"prefix":"10.1016","volume":"1845","author":[{"given":"Kunhao","family":"Ren","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linzhi","family":"Dai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hao","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaowen","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bin","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Youjie","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ketao","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weidong","family":"Tian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dong","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.brainres.2024.149293_b0005","doi-asserted-by":"crossref","DOI":"10.1016\/j.brainres.2019.146566","article-title":"Tauroursodeoxycholic acid prevents ER stress-induced apoptosis and improves cerebral and vascular function in mice subjected to subarachnoid hemorrhage","volume":"1727","author":"Chen","year":"2020","journal-title":"Brain Res."},{"key":"10.1016\/j.brainres.2024.149293_b0010","doi-asserted-by":"crossref","first-page":"846","DOI":"10.1016\/S0140-6736(22)00938-2","article-title":"Spontaneous subarachnoid haemorrhage","volume":"400","author":"Claassen","year":"2022","journal-title":"Lancet"},{"key":"10.1016\/j.brainres.2024.149293_b0015","doi-asserted-by":"crossref","first-page":"566","DOI":"10.1007\/s12975-018-0674-3","article-title":"The acute phase of experimental subarachnoid hemorrhage: intracranial pressure dynamics and their effect on cerebral blood flow and autoregulation","volume":"10","author":"Conzen","year":"2018","journal-title":"Transl. Stroke Res."},{"key":"10.1016\/j.brainres.2024.149293_b0020","doi-asserted-by":"crossref","DOI":"10.1186\/s12974-021-02207-x","article-title":"NLRP3 inhibition attenuates early brain injury and delayed cerebral vasospasm after subarachnoid hemorrhage","volume":"18","author":"Dodd","year":"2021","journal-title":"J. Neuroinflammation"},{"key":"10.1016\/j.brainres.2024.149293_b0025","doi-asserted-by":"crossref","DOI":"10.1001\/jamaneurol.2019.0006","article-title":"Worldwide incidence of aneurysmal subarachnoid hemorrhage according to region, time period, blood pressure, and smoking prevalence in the population","volume":"76","author":"Etminan","year":"2019","journal-title":"JAMA Neurol."},{"key":"10.1016\/j.brainres.2024.149293_b0030","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2022.113851","article-title":"BAY-117082-driven NLRP3 inflammasome inhibition resolves nitro-glycerine (NTG) neuronal damage in in vivo model of migraine","volume":"156","author":"Filippone","year":"2022","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.brainres.2024.149293_b0035","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1161\/01.STR.26.4.627","article-title":"Neurological deficit and extent of neuronal necrosis attributable to middle cerebral artery occlusion in rats. Statistical validation","volume":"26","author":"Garcia","year":"1995","journal-title":"Stroke"},{"key":"10.1016\/j.brainres.2024.149293_b0040","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1016\/j.bbi.2020.09.016","article-title":"INT-777 attenuates NLRP3-ASC inflammasome-mediated neuroinflammation via TGR5\/cAMP\/PKA signaling pathway after subarachnoid hemorrhage in rats","volume":"91","author":"Hu","year":"2021","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.brainres.2024.149293_b0045","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1007\/s12975-019-0690-y","article-title":"Two diverse hemodynamic forces, a mechanical stretch and a high wall shear stress, determine intracranial aneurysm formation","volume":"11","author":"Koseki","year":"2019","journal-title":"Transl. Stroke Res."},{"key":"10.1016\/j.brainres.2024.149293_b0050","doi-asserted-by":"crossref","first-page":"916","DOI":"10.1097\/01.WCB.0000125886.48838.7E","article-title":"Signaling pathways for early brain injury after subarachnoid hemorrhage","volume":"24","author":"Kusaka","year":"2004","journal-title":"J. Cereb. Blood Flow Metab."},{"key":"10.1016\/j.brainres.2024.149293_b0055","doi-asserted-by":"crossref","DOI":"10.1186\/s12974-022-02501-2","article-title":"Intermittent theta-burst stimulation improves motor function by inhibiting neuronal pyroptosis and regulating microglial polarization via TLR4\/NF\u03baB\/NLRP3 signaling pathway in cerebral ischemic mice","volume":"19","author":"Luo","year":"2022","journal-title":"J. Neuroinflammation"},{"key":"10.1016\/j.brainres.2024.149293_b0060","doi-asserted-by":"crossref","first-page":"588","DOI":"10.1038\/nrd.2018.97","article-title":"Targeting the NLRP3 inflammasome in inflammatory diseases","volume":"17","author":"Mangan","year":"2018","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.brainres.2024.149293_b0065","doi-asserted-by":"crossref","first-page":"654","DOI":"10.1007\/s12975-018-0665-4","article-title":"Apolipoprotein E exerts a whole-brain protective property by promoting M1? microglia quiescence after experimental subarachnoid hemorrhage in mice","volume":"9","author":"Pang","year":"2018","journal-title":"Transl. Stroke Res."},{"key":"10.1016\/j.brainres.2024.149293_b0070","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1038\/nn1407","article-title":"Soluble CPG15 expressed during early development rescues cortical progenitors from apoptosis","volume":"8","author":"Putz","year":"2005","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.brainres.2024.149293_b0075","doi-asserted-by":"crossref","DOI":"10.1042\/BSR20171035","article-title":"Atorvastatin ameliorates early brain injury through inhibition of apoptosis and ER stress in a rat model of subarachnoid hemorrhage","volume":"38","author":"Qi","year":"2018","journal-title":"Biosci. Rep."},{"key":"10.1016\/j.brainres.2024.149293_b0080","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1016\/j.neuron.2012.03.034","article-title":"High-resolution proteomics unravel architecture and molecular diversity of native AMPA receptor complexes","volume":"74","author":"Schwenk","year":"2012","journal-title":"Neuron"},{"key":"10.1016\/j.brainres.2024.149293_b0085","doi-asserted-by":"crossref","first-page":"1584","DOI":"10.1016\/j.celrep.2019.07.012","article-title":"CPG15\/neuritin mimics experience in selecting excitatory synapses for stabilization by facilitating PSD95 recruitment","volume":"28","author":"Subramanian","year":"2019","journal-title":"Cell Rep."},{"key":"10.1016\/j.brainres.2024.149293_b0090","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1016\/j.jneumeth.2007.08.004","article-title":"A new grading system evaluating bleeding scale in filament perforation subarachnoid hemorrhage rat model","volume":"167","author":"Sugawara","year":"2008","journal-title":"J. Neurosci. Methods"},{"key":"10.1016\/j.brainres.2024.149293_b0095","doi-asserted-by":"crossref","first-page":"1383","DOI":"10.1007\/s11064-018-2553-4","article-title":"Neuritin attenuates neuronal apoptosis mediated by endoplasmic reticulum stress in vitro","volume":"43","author":"Sun","year":"2018","journal-title":"Neurochem. Res."},{"key":"10.1016\/j.brainres.2024.149293_b0100","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1007\/s12975-019-00713-y","article-title":"Inflammation: a good research target to improve outcomes of poor-grade subarachnoid hemorrhage","volume":"10","author":"Suzuki","year":"2019","journal-title":"Transl. Stroke Res."},{"key":"10.1016\/j.brainres.2024.149293_b0105","doi-asserted-by":"crossref","DOI":"10.3389\/fncel.2021.739506","article-title":"Inflammation and oxidative stress: potential targets for improving prognosis after subarachnoid hemorrhage","volume":"15","author":"Wu","year":"2021","journal-title":"Front. Cell. Neurosci."},{"key":"10.1016\/j.brainres.2024.149293_b0110","article-title":"The role of the negative regulation of microglia-mediated neuroinflammation in improving emotional behavior after epileptic seizures","volume":"13","author":"Wu","year":"2022","journal-title":"Front. Neurol."},{"key":"10.1016\/j.brainres.2024.149293_b0115","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1186\/s40659-020-00323-1","article-title":"Tauroursodeoxycholic acid attenuates neuronal apoptosis via the TGR5\/ SIRT3 pathway after subarachnoid hemorrhage in rats","volume":"53","author":"Wu","year":"2020","journal-title":"Biol. Res."},{"key":"10.1016\/j.brainres.2024.149293_b0120","doi-asserted-by":"crossref","DOI":"10.1016\/j.jstrokecerebrovasdis.2023.107391","article-title":"Neuritin has a neuroprotective role in the rat model of acute ischemia stroke by inhibiting neuronal apoptosis and NLRP3 inflammasome","volume":"32","author":"Xu","year":"2023","journal-title":"J. Stroke Cerebrovasc. Dis."},{"key":"10.1016\/j.brainres.2024.149293_b0125","doi-asserted-by":"crossref","DOI":"10.1186\/s12974-019-1620-3","article-title":"Apelin-13\/APJ system attenuates early brain injury via suppression of endoplasmic reticulum stress-associated TXNIP\/NLRP3 inflammasome activation and oxidative stress in a AMPK-dependent manner after subarachnoid hemorrhage in rats","volume":"16","author":"Xu","year":"2019","journal-title":"J. Neuroinflammation"},{"key":"10.1016\/j.brainres.2024.149293_b0130","doi-asserted-by":"crossref","DOI":"10.1186\/s12974-021-02226-8","article-title":"TAK1 mediates neuronal pyroptosis in early brain injury after subarachnoid hemorrhage","volume":"18","author":"Xu","year":"2021","journal-title":"J. Neuroinflammation"},{"key":"10.1016\/j.brainres.2024.149293_b0135","doi-asserted-by":"crossref","DOI":"10.1186\/s12974-017-0895-5","article-title":"Isoliquiritigenin alleviates early brain injury after experimental intracerebral hemorrhage via suppressing ROS- and\/or NF-\u03baB-mediated NLRP3 inflammasome activation by promoting Nrf2 antioxidant pathway","volume":"14","author":"Zeng","year":"2017","journal-title":"J. Neuroinflammation"},{"key":"10.1016\/j.brainres.2024.149293_b0140","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1002\/hipo.20593","article-title":"Positive modulation of AMPA receptors prevents downregulation of GluR2 expression and activates the Lyn-ERK1\/2-CREB signaling in rat brain ischemia","volume":"20","author":"Zhang","year":"2009","journal-title":"Hippocampus"},{"key":"10.1016\/j.brainres.2024.149293_b0145","doi-asserted-by":"crossref","first-page":"1087","DOI":"10.1080\/00207454.2017.1337013","article-title":"Neuritin attenuates early brain injury in rats after experimental subarachnoid hemorrhage","volume":"127","author":"Zhang","year":"2017","journal-title":"Int. J. Neurosci."},{"key":"10.1016\/j.brainres.2024.149293_b0150","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1038\/nature07203","article-title":"From endoplasmic-reticulum stress to the inflammatory response","volume":"454","author":"Zhang","year":"2008","journal-title":"Nature"},{"key":"10.1016\/j.brainres.2024.149293_b0155","doi-asserted-by":"crossref","DOI":"10.1016\/j.yexcr.2021.112832","article-title":"Neuritin attenuates oxygen-glucose deprivation\/reoxygenation (OGD\/R)-induced neuronal injury by promoting autophagic flux","volume":"407","author":"Zhang","year":"2021","journal-title":"Exp. Cell Res."},{"key":"10.1016\/j.brainres.2024.149293_b0160","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1186\/s12974-017-0878-6","article-title":"Thioredoxin-interacting protein links endoplasmic reticulum stress to inflammatory brain injury and apoptosis after subarachnoid haemorrhage","volume":"14","author":"Zhao","year":"2017","journal-title":"J. Neuroinflammat."},{"key":"10.1016\/j.brainres.2024.149293_b0165","doi-asserted-by":"crossref","first-page":"1628","DOI":"10.1523\/JNEUROSCI.1611-16.2016","article-title":"Soluble cpg15 from astrocytes ameliorates neurite outgrowth recovery of hippocampal neurons after mouse cerebral ischemia","volume":"37","author":"Zhao","year":"2017","journal-title":"J. Neurosci."}],"container-title":["Brain Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S000689932400547X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S000689932400547X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T23:50:22Z","timestamp":1783122622000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S000689932400547X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,12]]},"references-count":33,"alternative-id":["S000689932400547X"],"URL":"https:\/\/doi.org\/10.1016\/j.brainres.2024.149293","relation":{},"ISSN":["0006-8993"],"issn-type":[{"value":"0006-8993","type":"print"}],"subject":[],"published":{"date-parts":[[2024,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Neuritin attenuates neuroinflammation and apoptosis in early brain injury after subarachnoid hemorrhage via endoplasmic reticulum stress-related inflammatory pathways","name":"articletitle","label":"Article Title"},{"value":"Brain Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.brainres.2024.149293","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"149293"}}