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Biol."},{"key":"10.1016\/j.brainres.2024.149308_b0435","first-page":"511","article-title":"The effect of hydroalcoholic extract of Satureja hortensis on outcomes of stroke in rat Abstract : Background : Antioxidants can prevent oxidative stress produced by free radicals","volume":"19","author":"Rahnema","year":"2016","journal-title":"Since Satureja Hortensis Contains Various Antioxidant Compounds, This St"},{"key":"10.1016\/j.brainres.2024.149308_b0440","doi-asserted-by":"crossref","DOI":"10.1155\/2017\/4863079","article-title":"Phase i and Phase II Therapies for Acute Ischemic Stroke: An Update on Currently Studied Drugs in Clinical Research","author":"Reis","year":"2017","journal-title":"Biomed Res. 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