{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,23]],"date-time":"2026-04-23T07:41:10Z","timestamp":1776930070594,"version":"3.51.2"},"reference-count":43,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Brain Research"],"published-print":{"date-parts":[[2025,2]]},"DOI":"10.1016\/j.brainres.2024.149336","type":"journal-article","created":{"date-parts":[[2024,11,14]],"date-time":"2024-11-14T06:08:49Z","timestamp":1731564529000},"page":"149336","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["Diosmin alleviates NLRP3 inflammasome-dependent cellular pyroptosis after stroke through RSK2\/CREB pathway"],"prefix":"10.1016","volume":"1848","author":[{"given":"Yanfei","family":"Lu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3228-1949","authenticated-orcid":false,"given":"Min","family":"Shi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei","family":"Huang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fenfen","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haowei","family":"Liang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wenbing","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tianyi","family":"Huang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhen","family":"Xu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.brainres.2024.149336_b0005","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1158\/1541-7786.MCR-13-0595","article-title":"Novel potent and selective inhibitors of p90 ribosomal S6 kinase reveal the heterogeneity of RSK function in MAPK-driven cancers","volume":"12","author":"Aronchik","year":"2014","journal-title":"Mol. Cancer Res."},{"key":"10.1016\/j.brainres.2024.149336_b0010","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1016\/j.biopha.2017.10.077","article-title":"Central and peripheral anti-hyperalgesic effects of diosmin in a neuropathic pain model in rats","volume":"97","author":"Carballo-Villalobos","year":"2018","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.brainres.2024.149336_b0015","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1007\/s12272-016-0880-z","article-title":"RSK2 and its binding partners in cell proliferation, transformation and cancer development","volume":"40","author":"Cho","year":"2017","journal-title":"Arch. Pharm. Res."},{"key":"10.1016\/j.brainres.2024.149336_b0020","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1007\/s00281-022-00943-7","article-title":"Inflammatory Responses After Ischemic Stroke","volume":"44","author":"DeLong","year":"2022","journal-title":"Semin. Immunopathol."},{"key":"10.1016\/j.brainres.2024.149336_b0025","doi-asserted-by":"crossref","first-page":"1039","DOI":"10.1016\/j.tiv.2011.04.003","article-title":"Protective effect of diosmin on LPS-induced apoptosis in PC12 cells and inhibition of TNF-\u03b1 expression","volume":"25","author":"Dholakiya","year":"2011","journal-title":"Toxicol. In Vitro"},{"key":"10.1016\/j.brainres.2024.149336_b0030","doi-asserted-by":"crossref","first-page":"1457","DOI":"10.1016\/j.amjmed.2021.07.027","article-title":"Ischemic Stroke","volume":"134","author":"Feske","year":"2021","journal-title":"Am. J. Med."},{"key":"10.1016\/j.brainres.2024.149336_b0035","doi-asserted-by":"crossref","first-page":"3871","DOI":"10.2174\/092986711803414368","article-title":"Antioxidant therapy: current status and future prospects","volume":"18","author":"Firuzi","year":"2011","journal-title":"Curr. Med. Chem."},{"key":"10.1016\/j.brainres.2024.149336_b0040","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s13318-021-00731-y","article-title":"Pharmacology of Diosmin, a Citrus Flavone Glycoside: An Updated Review","volume":"47","author":"Gerges","year":"2022","journal-title":"Eur. J. Drug Metab. Pharmacokinet."},{"key":"10.1016\/j.brainres.2024.149336_b0045","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1007\/s00210-022-02295-3","article-title":"Diosmin prophylaxis reduces gentamicin-induced kidney damage in rats","volume":"396","author":"Geshnigani","year":"2023","journal-title":"Naunyn Schmiedebergs Arch. Pharmacol."},{"key":"10.1016\/j.brainres.2024.149336_b0050","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1007\/s13105-021-00817-w","article-title":"Pyroptosis in stroke-new insights into disease mechanisms and therapeutic strategies","volume":"77","author":"Gou","year":"2021","journal-title":"J. Physiol. Biochem."},{"key":"10.1016\/j.brainres.2024.149336_b0055","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejphar.2021.174573","article-title":"The potential neuroprotective effect of diosmin in rotenone-induced model of Parkinson's disease in rats","volume":"914","author":"Habib","year":"2022","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.brainres.2024.149336_b0060","doi-asserted-by":"crossref","DOI":"10.1007\/s11064-023-04007-6","article-title":"The m(6)A Reader YTHDF1 Improves Sevoflurane-Induced Neuronal Pyroptosis and Cognitive Dysfunction Through Augmenting CREB-BDNF Signaling","author":"Huang","year":"2023","journal-title":"Neurochem. Res."},{"key":"10.1016\/j.brainres.2024.149336_b0065","doi-asserted-by":"crossref","DOI":"10.3390\/biomedicines10051076","article-title":"Potential and Therapeutic Roles of Diosmin in Human Diseases","volume":"10","author":"Huwait","year":"2022","journal-title":"Biomedicines."},{"key":"10.1016\/j.brainres.2024.149336_b0070","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2022.111827","article-title":"EGFR-phosphorylated GDH1 harmonizes with RSK2 to drive CREB activation and tumor metastasis in EGFR-activated lung cancer","volume":"41","author":"Kang","year":"2022","journal-title":"Cell Rep."},{"key":"10.1016\/j.brainres.2024.149336_b0075","doi-asserted-by":"crossref","first-page":"4652","DOI":"10.1074\/jbc.M709673200","article-title":"Epidermal growth factor stimulates RSK2 activation through activation of the MEK\/ERK pathway and src-dependent tyrosine phosphorylation of RSK2 at Tyr-529","volume":"283","author":"Kang","year":"2008","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.brainres.2024.149336_b0080","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1111\/j.1471-4159.2007.04774.x","article-title":"Co-application of NMDA and dopamine-induced rapid translation of RSK2 in the mature hippocampus","volume":"103","author":"Kaphzan","year":"2007","journal-title":"J. Neurochem."},{"key":"10.1016\/j.brainres.2024.149336_b0085","series-title":"The Marine-Derived Natural Product Epiloliolide Isolated from Sargassum horneri Regulates NLRP3 via PKA\/CREB","first-page":"19","author":"Kim","year":"2021"},{"key":"10.1016\/j.brainres.2024.149336_b0090","doi-asserted-by":"crossref","first-page":"9071","DOI":"10.18632\/aging.202762","article-title":"Long non-coding RNA THRIL inhibits miRNA-24-3p to upregulate neuropilin-1 to aggravate cerebral ischemia-reperfusion injury through regulating the nuclear factor \u03baB p65 signaling","volume":"13","author":"Kuai","year":"2021","journal-title":"Aging (Albany NY)"},{"key":"10.1016\/j.brainres.2024.149336_b0095","doi-asserted-by":"crossref","DOI":"10.1210\/endocr\/bqac106","article-title":"ERK1\/2-RSK2 Signaling in Regulation of ER\u03b1-Mediated Responses","volume":"163","author":"Lannigan","year":"2022","journal-title":"Endocrinology"},{"key":"10.1016\/j.brainres.2024.149336_b0100","doi-asserted-by":"crossref","DOI":"10.1016\/j.arabjc.2022.104302","article-title":"Unraveling the mystery of efficacy in Chinese medicine formula: New approaches and technologies for research on pharmacodynamic substances","volume":"15","author":"Li","year":"2022","journal-title":"Arab. J. Chem."},{"key":"10.1016\/j.brainres.2024.149336_b0105","article-title":"The Signaling Pathways and Targets of Natural Compounds from Traditional Chinese Medicine in Treating Ischemic Stroke","volume":"27","author":"Li","year":"2022","journal-title":"Molecules"},{"key":"10.1016\/j.brainres.2024.149336_b0110","doi-asserted-by":"crossref","first-page":"554","DOI":"10.1016\/j.bbrc.2020.05.056","article-title":"TREM-1-targeting LP17 attenuates cerebral ischemia-induced neuronal injury by inhibiting oxidative stress and pyroptosis","volume":"529","author":"Liang","year":"2020","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.brainres.2024.149336_b0115","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1016\/j.neuroscience.2014.03.032","article-title":"Diosmin protects against cerebral ischemia\/reperfusion injury through activating JAK2\/STAT3 signal pathway in mice","volume":"268","author":"Liu","year":"2014","journal-title":"Neuroscience"},{"key":"10.1016\/j.brainres.2024.149336_b0120","first-page":"2346","article-title":"Study on active components and mechanism of Jieyudan Decoction in the treatment of stroke based on network pharmacology and UPLC-Q\/TOF-MS","volume":"42","author":"Lu","year":"2022","journal-title":"Chinese Journal of Hospital Pharmacy."},{"key":"10.1016\/j.brainres.2024.149336_b0125","doi-asserted-by":"crossref","first-page":"1088","DOI":"10.1001\/jama.2020.26867","article-title":"Diagnosis and Management of Transient Ischemic Attack and Acute Ischemic Stroke: A Review","volume":"325","author":"Mendelson","year":"2021","journal-title":"J. Am. Med. Assoc."},{"key":"10.1016\/j.brainres.2024.149336_b0130","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1186\/s42826-019-0019-8","article-title":"Resveratrol modulates the Akt\/GSK-3\u03b2 signaling pathway in a middle cerebral artery occlusion animal model","volume":"35","author":"Park","year":"2019","journal-title":"Lab. Anim. Res."},{"key":"10.1016\/j.brainres.2024.149336_b0135","doi-asserted-by":"crossref","DOI":"10.1016\/j.expneurol.2020.113518","article-title":"Emerging neuroprotective strategies for the treatment of ischemic stroke: An overview of clinical and preclinical studies","volume":"335","author":"Paul","year":"2021","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.brainres.2024.149336_b0140","doi-asserted-by":"crossref","first-page":"4578","DOI":"10.7150\/ijbs.69892","article-title":"Artemisinin attenuated ischemic stroke induced cell apoptosis through activation of ERK1\/2\/CREB\/BCL-2 signaling pathway in vitro and in vivo","volume":"18","author":"Peng","year":"2022","journal-title":"Int. J. Biol. Sci."},{"key":"10.1016\/j.brainres.2024.149336_b0145","doi-asserted-by":"crossref","DOI":"10.3390\/ijms23020706","article-title":"ERK1\/2 Activity Is Critical for the Outcome of Ischemic Stroke","volume":"23","author":"Schanbacher","year":"2022","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.brainres.2024.149336_b0150","doi-asserted-by":"crossref","first-page":"1376","DOI":"10.1016\/j.biopha.2018.09.127","article-title":"Diosmin is neuroprotective in a rat model of scopolamine-induced cognitive impairment","volume":"108","author":"Shabani","year":"2018","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.brainres.2024.149336_b0155","doi-asserted-by":"crossref","first-page":"e43848","DOI":"10.1371\/journal.pone.0043848","article-title":"HPLC-MS\/MS analysis of a traditional Chinese medical formulation of Bu-Yang-Huan-Wu-Tang and its pharmacokinetics after oral administration to rats","volume":"7","author":"Shaw","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.brainres.2024.149336_b0160","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1002\/med.21817","article-title":"Mechanisms of neuronal cell death in ischemic stroke and their therapeutic implications","volume":"42","author":"Tuo","year":"2022","journal-title":"Med. Res. Rev."},{"key":"10.1016\/j.brainres.2024.149336_b0165","doi-asserted-by":"crossref","first-page":"957","DOI":"10.1111\/j.1471-4159.2007.04606.x","article-title":"Brain-derived neurotrophic factor stimulates the transcriptional and neuroprotective activity of myocyte-enhancer factor 2C through an ERK1\/2-RSK2 signaling cascade","volume":"102","author":"Wang","year":"2007","journal-title":"J. Neurochem."},{"key":"10.1016\/j.brainres.2024.149336_b0170","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2021.105640","article-title":"Medioresinol as a novel PGC-1\u03b1 activator prevents pyroptosis of endothelial cells in ischemic stroke through PPAR\u03b1-GOT1 axis","volume":"169","author":"Wang","year":"2021","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.brainres.2024.149336_b0175","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1111\/joa.13185","article-title":"RSK3 mediates necroptosis by regulating phosphorylation of RIP3 in rat retinal ganglion cells","volume":"237","author":"Wang","year":"2020","journal-title":"J. Anat."},{"key":"10.1016\/j.brainres.2024.149336_b0180","first-page":"1583","article-title":"Overexpression of phosphoprotein enriched in astrocytes15 reverses the damage induced by propofol in hippocampal neurons","volume":"20","author":"Xian","year":"2019","journal-title":"Mol. Med. Rep."},{"key":"10.1016\/j.brainres.2024.149336_b0185","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1186\/s12906-023-03990-1","article-title":"Screening of key functional components of Taohong Siwu Decoction on ischemic stroke treatment based on multiobjective optimization approach and experimental validation","volume":"23","author":"Xu","year":"2023","journal-title":"BMC Complement Med Ther."},{"key":"10.1016\/j.brainres.2024.149336_b0190","doi-asserted-by":"crossref","first-page":"4021","DOI":"10.1161\/STROKEAHA.120.033285","article-title":"CCR5 Activation Promotes NLRP1-Dependent Neuronal Pyroptosis via CCR5\/PKA\/CREB Pathway After Intracerebral Hemorrhage","volume":"52","author":"Yan","year":"2021","journal-title":"Stroke"},{"key":"10.1016\/j.brainres.2024.149336_b0195","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1503\/jpn.130169","article-title":"BDNF-ERK-CREB signalling mediates the role of miR-132 in the regulation of the effects of oleanolic acid in male mice","volume":"39","author":"Yi","year":"2014","journal-title":"J. Psychiatry Neurosci."},{"key":"10.1016\/j.brainres.2024.149336_b0200","doi-asserted-by":"crossref","first-page":"8472","DOI":"10.1039\/D0FO01598A","article-title":"Metabolism and pharmacological activities of the natural health-benefiting compound diosmin","volume":"11","author":"Zheng","year":"2020","journal-title":"Food Funct."},{"key":"10.1016\/j.brainres.2024.149336_b0205","doi-asserted-by":"crossref","DOI":"10.1016\/j.tox.2023.153582","article-title":"Upregulation of postsynaptic cAMP\/PKA\/CREB signaling alleviates copper(\u2161)-induced oxidative stress and pyroptosis in MN9D cells","volume":"494","author":"Zhou","year":"2023","journal-title":"Toxicology"},{"key":"10.1016\/j.brainres.2024.149336_b0210","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2022.112719","article-title":"Therapeutic targets of neuroprotection and neurorestoration in ischemic stroke: Applications for natural compounds from medicinal herbs","volume":"148","author":"Zhu","year":"2022","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.brainres.2024.149336_b0215","doi-asserted-by":"crossref","first-page":"1520","DOI":"10.1007\/s12035-014-8831-5","article-title":"RKIP Regulates Neural Cell Apoptosis Induced by Exposure to Microwave Radiation Partly Through the MEK\/ERK\/CREB Pathway","volume":"51","author":"Zuo","year":"2015","journal-title":"Mol. Neurobiol."}],"container-title":["Brain Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006899324005900?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006899324005900?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,1,14]],"date-time":"2026-01-14T01:25:38Z","timestamp":1768353938000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006899324005900"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,2]]},"references-count":43,"alternative-id":["S0006899324005900"],"URL":"https:\/\/doi.org\/10.1016\/j.brainres.2024.149336","relation":{},"ISSN":["0006-8993"],"issn-type":[{"value":"0006-8993","type":"print"}],"subject":[],"published":{"date-parts":[[2025,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Diosmin alleviates NLRP3 inflammasome-dependent cellular pyroptosis after stroke through RSK2\/CREB pathway","name":"articletitle","label":"Article Title"},{"value":"Brain Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.brainres.2024.149336","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"149336"}}